Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

PXDN FBXL8 LRRC10B LINGO4 TPBGL FBXL6

3.17e-043215463.80.10.10
DomainL_dom-like

PXDN FBXL8 LRRC10B LINGO4 TPBGL FBXL6

3.56e-04328546IPR032675
DomainMRGPCRFAMILY

MRGPRE MRGPRX2

4.44e-0411542IPR026234
DomainF-box

FBXL8 FBXO27 FBXL6

9.60e-0467543PF00646
DomainLeu-rich_rpt

PXDN LRRC10B LINGO4 TPBGL FBXL6

1.10e-03271545IPR001611
DomainFBOX

FBXL8 FBXO27 FBXL6

1.18e-0372543PS50181
DomainF-box_dom

FBXL8 FBXO27 FBXL6

1.33e-0375543IPR001810
DomainLRR_8

PXDN LRRC10B LINGO4 TPBGL

1.50e-03171544PF13855
DomainIGFBP-like

IGFBP6 HTRA4

1.51e-0320542IPR000867
DomainIGFBP

IGFBP6 HTRA4

1.51e-0320542PF00219
DomainIGFBP_N_2

IGFBP6 HTRA4

1.51e-0320542PS51323
DomainLeu-rich_rpt_typical-subtyp

PXDN LRRC10B LINGO4 TPBGL

1.70e-03177544IPR003591
DomainLRR_TYP

PXDN LRRC10B LINGO4 TPBGL

1.70e-03177544SM00369
DomainIg_I-set

PXDN HMCN2 LINGO4 MDGA1

2.21e-03190544IPR013098
DomainI-set

PXDN HMCN2 LINGO4 MDGA1

2.21e-03190544PF07679
DomainCys-rich_flank_reg_C

PXDN LINGO4 TPBGL

2.25e-0390543IPR000483
DomainLRRCT

PXDN LINGO4 TPBGL

2.25e-0390543SM00082
DomainK_chnl_volt-dep_Kv

KCNG2 KCNV2

2.75e-0327542IPR003968
DomainLRR_1

PXDN LRRC10B LINGO4 FBXL6

3.68e-03219544PF00560
DomainVG_K_chnl

KCNG2 KCNV2

4.09e-0333542IPR028325
DomainIGc2

PXDN HMCN2 LINGO4 MDGA1

4.72e-03235544SM00408
DomainIg_sub2

PXDN HMCN2 LINGO4 MDGA1

4.72e-03235544IPR003598
DomainVWFC_1

PXDN SSPOP

4.85e-0336542PS01208
DomainCadherin_tail

PCDHAC2 PCDHGA8

5.12e-0337542PF15974
DomainCadherin_CBD

PCDHAC2 PCDHGA8

5.12e-0337542IPR031904
DomainVWC

PXDN SSPOP

5.40e-0338542SM00214
DomainVWFC_2

PXDN SSPOP

5.40e-0338542PS50184
DomainCadherin_C

PCDHAC2 PCDHGA8

6.56e-0342542IPR032455
DomainCadherin_C_2

PCDHAC2 PCDHGA8

6.56e-0342542PF16492
DomainVWF_dom

PXDN SSPOP

6.56e-0342542IPR001007
DomainF-box-like

FBXL8 FBXL6

7.18e-0344542PF12937
Pubmed

IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses.

IL15RA STING1

2.45e-05555230587590
Pubmed

Gli regulation by the opposing activities of fused and suppressor of fused.

STK36 SUFU

2.45e-05555210806483
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

STK36 ABCA2 CARNS1 SSPOP

5.48e-0513055412421765
Pubmed

Expression of hedgehog signalling components in adult mouse testis.

STK36 SUFU

6.83e-05855216958114
Pubmed

Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.

MRGPRE MRGPRX2

6.83e-05855224583173
Pubmed

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.

MRGPRE MRGPRX2

6.83e-05855212909716
Pubmed

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.

MRGPRE MRGPRX2

8.78e-05955212397184
Pubmed

Systematic analysis and nomenclature of mammalian F-box proteins.

FBXL8 FBXO27 FBXL6

1.26e-046155315520277
Pubmed

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.

MRGPRE MRGPRX2

1.34e-041155211551509
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

ABCA2 PXDN SGSH COLGALT1

1.35e-0416455432409323
Pubmed

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

STK36 SUFU

1.89e-041355219684112
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

MDGA1 SSPOP

2.54e-041555220473291
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

FBXL8 RNF213 FBXO27

3.37e-048555319028597
Pubmed

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.

TREX2 XRCC3

7.79e-042655223435420
Pubmed

Array MAPPIT: high-throughput interactome analysis in mammalian cells.

FBXL8 FBXL6

7.79e-042655219159283
Pubmed

Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.

PXDN LINGO4

1.33e-033455218848646
Pubmed

Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.

ARMC5 LONRF2 FBXL6

1.38e-0313855328786561
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PXDN HMCN2 LINGO4 MDGA1

2.28e-04161344593
GeneFamilyF-box and leucine rich repeat proteins

FBXL8 FBXL6

7.05e-0421342558
GeneFamilyPotassium voltage-gated channels

KCNG2 KCNV2

2.56e-0340342274
GeneFamilyClustered protocadherins

PCDHAC2 PCDHGA8

6.43e-036434220
GeneFamilyG protein-coupled receptors, Class A orphans

MRGPRE MRGPRX2

9.43e-0378342262
GeneFamilyRing finger proteins

RNF213 LONRF2 RNF207

1.47e-0227534358
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STK36 HMCN2 IGFBP6 KREMEN2 TNFRSF4

1.87e-0616256534b4cd3d2258f88dfbd6d32abd1db87aff8a6b6f
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STK36 HMCN2 IGFBP6 KREMEN2 TNFRSF4

1.93e-0616356556b8668dbf06faa6866ec71f29b92907b73f074d
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK36 IGFBP6 ADAMTS2 TPBGL LONRF2

3.68e-06186565827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGFBP6 ADAMTS2 IYD TPBGL HTRA4

4.41e-06193565025836c5c5a711e477c326559e618e47cae42d11
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PXDN HMCN2 STING1 MDGA1 RNF207

5.12e-06199565eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNG2 KCNV2 IYD TPBGL

3.34e-0514556478f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Tgfb1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PXDN IGFBP6 LRRC10B HTRA4

3.34e-0514556484d50a13b48d50c16e768422908e371a55972d0e
ToppCellfacs-Marrow-KLS-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS2 TMEM121B LINGO4 SSPOP

4.22e-0515456437765512dfae557b9f6eb30a29463b93682a4404
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PXDN IGFBP6 ADAMTS2 STOX1

5.92e-051685643fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|368C / Donor, Lineage, Cell class and subclass (all cells)

RCL1 PRRT3 RNF207 TNFRSF4

6.06e-051695640d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HMCN2 IYD TPBGL MAP3K1

6.34e-05171564f9ae7964a3740f559431125c17c660549798cccc
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP6 ADAMTS2 HTRA4 RNF207

7.41e-0517856427497dbfcf9bb4dd0bf7caa0bd78c7e85f5c18ee
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP6 ADAMTS2 HTRA4 RNF207

7.41e-05178564d348a9550db940d204706529759dc51e30506b5f
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HMCN2 IGFBP6 ADAMTS2 IYD

7.74e-051805649adebde5f4ca6dcb90e9113622862e14298465ac
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP6 ADAMTS2 MDGA1 TNFRSF4

7.90e-051815640ec9621a078d004bbd25a587757d24b5cf162959
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP6 ADAMTS2 MDGA1 TNFRSF4

7.90e-05181564c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HMCN2 IGFBP6 ADAMTS2 IYD

8.07e-05182564e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 PXDN TPBGL STOX1

8.60e-05185564742350093d90f96735dc73e3360cdd749bae63fd
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGFBP6 ADAMTS2 DIPK1B HTRA4

9.15e-051885646c6486cae9a8f2f8200598cb4bfd3fd513eb28a3
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN2 IGFBP6 ADAMTS2 IYD

9.92e-05192564cdc652dbfabe41b324fd85c1ed933d29fb73a49f
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGFBP6 ADAMTS2 IYD HTRA4

9.92e-051925640e7e55505bd5454d7cf952a63fdcb46ec76f1973
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN2 IGFBP6 ADAMTS2 IYD

9.92e-0519256429bee88b45e23f16543ffc7cc361bc5da5d16a2b
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP6 ADAMTS2 IYD HTRA4

1.01e-04193564858a186804b36d45957238d3d3eed2768b961641
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP6 ADAMTS2 IYD HTRA4

1.01e-041935647865e7ec0a288249540d4cba94ae01c93e1b617c
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Entopeduncular / BrainAtlas - Mouse McCarroll V32

KREMEN2 LINGO4 RNF207

1.02e-04725637877184d5c9dd6d96476d71e7504e58c0b4d0f26
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

PXDN HMCN2 IGFBP6 ADAMTS2

1.03e-04194564d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal-Unfolded_protein_responsible_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

ANKLE1 TPBGL FITM1 CARNS1

1.05e-041955649873de83b67e9645112897d3391c2d9afaa9970e
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PXDN IGFBP6 ADAMTS2 CYP7B1

1.07e-04196564525d6c8a277364e624e7cc586275f8a891436b57
ToppCellCaecum-T_cell-Tfh|T_cell / Region, Cell class and subclass

SGSH IYD LINGO4 XRCC3

1.07e-04196564fe2ee5788028e6b671674f0cc50e2b6379f50976
ToppCellFibroblasts-DKK3+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

PXDN HMCN2 IGFBP6 ADAMTS2

1.12e-041985644f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCellmLN-B_cell-B_cell_IgA_Plasma|B_cell / Region, Cell class and subclass

PXDN STING1 SSPOP TNFRSF4

1.14e-0419956409494953bc7fff63cf2763ea89fca7abb97c186f
ToppCellCaecum-T_cell-Tfh|Caecum / Region, Cell class and subclass

IYD LINGO4 STING1 XRCC3

1.14e-04199564fb40f37d842f170ed101dfa3bffdb8f3b2c94f19
ToppCellCaecum-(1)_T_cell-(16)_Tfh|Caecum / shred on region, Cell_type, and subtype

IYD LINGO4 STING1 XRCC3

1.14e-04199564d07d77ae426dd1164d80d7031f14befa0369d3e5
Diseasevisceral adipose tissue measurement, body mass index

ADAMTS2 RHBG PCDHAC2

4.65e-0487513EFO_0004340, EFO_0004765
DiseasePigmented Basal Cell Carcinoma

XRCC3 SUFU

1.08e-0328512C1368275
DiseaseCarcinoma, Basal Cell

XRCC3 SUFU

1.15e-0329512C4721806
DiseaseGastrointestinal Stromal Sarcoma

STK36 SUFU

3.01e-0347512C3179349
DiseaseGastrointestinal Stromal Tumors

STK36 SUFU

3.40e-0350512C0238198

Protein segments in the cluster

PeptideGeneStartEntry
LRCFELRQGLSLLRP

ADCK2

16

Q7Z695
RHPRGLRCLGALLRQ

ANKLE1

51

Q8NAG6
PTEARLRLLGLCQGL

CARNS1

796

A5YM72
FRARGGLRPLLALLR

ARMC5

61

Q96C12
LRLLDLRGCARITPA

FBXL6

386

Q8N531
QGRLPGLRVRCIFLA

DIPK1B

21

Q5VUD6
GAARRLLCPALLLLL

ADAMTS2

6

O95450
RVVFGLGRLGPRALC

C17orf113

566

A0A1B0GUU1
LPEDLGRNCARLLLE

RCL1

271

Q9Y2P8
SRPRRGELILLCALL

PCDHGA8

6

Q9Y5G5
ALGRPVLLRCSLLRG

MDGA1

551

Q8NFP4
ARGCRTLGLPALLLL

IL15RA

6

Q13261
RQGRDLRVLALLPCE

HMCN2

3766

Q8NDA2
RAGKLRLLRGPCALA

KCNG2

86

Q9UJ96
LLLLGLLRPLRRRSC

KREMEN2

381

Q8NCW0
LLRPLRRRSCLLAPG

KREMEN2

386

Q8NCW0
LCRLPRLTRLYLGGN

LRRC10B

86

A6NIK2
CLRLGDALARAGRLP

LONRF2

61

Q1L5Z9
RGLCRPLRPLLGFRE

C6orf223

176

Q8N319
CLGSAQGRRLPLRLV

MRGPRE

271

Q86SM8
GLELRRLGPGCLRIN

PCDHAC2

66

Q9Y5I4
LRTAGLGRCLLPGLL

HTRA4

6

P83105
VLRAPRCGRGLALGR

GRID2IP

101

A4D2P6
EQAARLLGSPCLRRL

FITM1

41

A5D6W6
LAGRAPGLRGLRLEC

FBXL8

96

Q96CD0
ACALLDGLNRGRPRL

CTU1

301

Q7Z7A3
ERCLQLLRPGGILAV

COMTD1

196

Q86VU5
RILAVDRLCLGVRPG

ABCA2

2066

Q9BZC7
LREPGAGLRLLRFLC

FAM98C

106

Q17RN3
LALCLLVRRTRRPGE

CYP7B1

31

O75881
RAGRRRGQPLLALLL

COLGALT1

6

Q8NBJ5
LGRFCARRPIGRNLI

FBXO27

101

Q8NI29
TLCLCRRRLLDGPRG

PRRT3

616

Q5FWE3
AEYCPGTGRLRLRLL

C2CD4A

261

Q8NCU7
EAPLRALLLGRGRCL

IGFBP6

91

P24592
ALLLGRGRCLPARAP

IGFBP6

96

P24592
LRELDIGRLPAGALR

LINGO4

211

Q6UY18
LNCGPRLRVLLGRPA

IYD

241

Q6PHW0
GRLCLIDRLLLEFPA

MAP3K1

756

Q13233
FARCLEPLLLLGPRR

RNF207

346

Q6ZRF8
RACLGCPLRRGALLL

STING1

86

Q86WV6
QGRSRRCSPLGLLVL

SSPOP

1716

A2VEC9
SRLLRLLGGCLVDVP

TMEM121B

466

Q9BXQ6
LSGVLLVLDGLCPRR

KCNV2

166

Q8TDN2
RLLRTGAPAAACLRL

PPA2

6

Q9H2U2
LVRILCGSRGLPLTR

MRGPRX2

206

Q96LB1
LLLVLGLCRARPRNA

SGSH

11

P51688
GLCRARPRNALLLLA

SGSH

16

P51688
CREAGLPGLLLSLLR

STK36

496

Q9NRP7
FEILLPRRRGLGLCA

RNF213

4866

Q63HN8
SRAAGRRLQLPLLCL

RHBG

6

Q9H310
LRRGVLLVRAPPACL

STOX1

66

Q6ZVD7
RKLLCGLCPGALGRL

TMC4

506

Q7Z404
RGPGRRCLLALVLFC

PXDN

6

Q92626
ESGALIPLCLRGRLL

SUFU

376

Q9UMX1
RRLGRGPCAALLLLG

TNFRSF4

6

P43489
LDRPLLDLDGARLRC

TPBGL

271

P0DKB5
LLCAELRRLGARLPR

TREX2

126

Q9BQ50
LRRLGARLPRDTVCL

TREX2

131

Q9BQ50
RLSLGCPVLDALLRG

XRCC3

81

O43542
EGLLRRVRCLQLGSP

KIAA2013

146

Q8IYS2