Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	thiosulfate sulfurtransferase activity	MOCS3 UBA6	1.82e-04	5	86	2	GO:0004792
GeneOntologyMolecularFunction	fatty acyl-CoA hydrolase activity	ACOT1 ACOT2 ACOT4	2.09e-04	27	86	3	GO:0047617
GeneOntologyMolecularFunction	acyl-CoA hydrolase activity	ACOT1 ACOT2 ACOT4	2.34e-04	28	86	3	GO:0016289
GeneOntologyMolecularFunction	RNA endonuclease activity	AGO1 ANKZF1 ERN2 PIWIL3	3.77e-04	79	86	4	GO:0004521
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	MARS2 AGO1 POLR1B TRMT61B ANKZF1 ERN2 PIWIL3 PARS2	4.33e-04	417	86	8	GO:0140098
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	MARS2 AGO1 POLR1B TRMT61B TEP1 ANKZF1 ERN2 TOP3B PIWIL3 PARS2	4.48e-04	645	86	10	GO:0140640
GeneOntologyMolecularFunction	nucleotidyltransferase activity	MOCS3 FLAD1 UBA6 POLR1B TEP1	5.08e-04	152	86	5	GO:0016779
GeneOntologyMolecularFunction	LIM domain binding	KAT14 LDB2	6.47e-04	9	86	2	GO:0030274
GeneOntologyMolecularFunction	ubiquitin-like modifier activating enzyme activity	MOCS3 UBA6	8.07e-04	10	86	2	GO:0008641
GeneOntologyMolecularFunction	ligase activity	MARS2 MOCS3 UBA6 ATP5F1A PARS2	9.35e-04	174	86	5	GO:0016874
GeneOntologyMolecularFunction	thiolester hydrolase activity	ACOT1 ACOT2 ACOT4	1.09e-03	47	86	3	GO:0016790
GeneOntologyMolecularFunction	sulfurtransferase activity	MOCS3 UBA6	1.18e-03	12	86	2	GO:0016783
GeneOntologyBiologicalProcess	saturated monocarboxylic acid metabolic process	ACOT1 ACOT4	1.68e-05	2	85	2	GO:0032788
GeneOntologyBiologicalProcess	unsaturated monocarboxylic acid metabolic process	ACOT1 ACOT4	1.68e-05	2	85	2	GO:0032789
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA catabolic process	ACOT1 ACOT2	5.02e-05	3	85	2	GO:0036116
GeneOntologyCellularComponent	mitochondrial matrix	MARS2 FLAD1 PYROXD2 BCKDHB ACOT2 SARDH TRMT61B HIBADH ATP5F1A PARS2	5.69e-05	523	86	10	GO:0005759
GeneOntologyCellularComponent	microbody	SZT2 PIPOX ACOT1 ACOT2 ACOT4	5.52e-04	162	86	5	GO:0042579
GeneOntologyCellularComponent	peroxisome	SZT2 PIPOX ACOT1 ACOT2 ACOT4	5.52e-04	162	86	5	GO:0005777
Domain	Bile_Hydr_Trans	ACOT1 ACOT2 ACOT4	3.76e-07	4	86	3	PF04775
Domain	Thio_Ohase/aa_AcTrfase	ACOT1 ACOT2 ACOT4	3.76e-07	4	86	3	IPR006862
Domain	Acyl-CoA_thioEstase_long-chain	ACOT1 ACOT2 ACOT4	3.76e-07	4	86	3	IPR016662
Domain	BAAT_C	ACOT1 ACOT2 ACOT4	9.36e-07	5	86	3	IPR014940
Domain	BAAT_C	ACOT1 ACOT2 ACOT4	9.36e-07	5	86	3	PF08840
Domain	TIFA	TIFAB TIFA	2.10e-05	2	86	2	IPR033621
Domain	Topo_IA_cen_sub2	RBBP6 TOP3B	6.27e-05	3	86	2	IPR013825
Domain	PIWI	AGO1 PIWIL3	5.76e-04	8	86	2	PS50822
Domain	Piwi	AGO1 PIWIL3	5.76e-04	8	86	2	SM00950
Domain	Piwi	AGO1 PIWIL3	5.76e-04	8	86	2	IPR003165
Domain	Piwi	AGO1 PIWIL3	5.76e-04	8	86	2	PF02171
Domain	PAZ	AGO1 PIWIL3	7.39e-04	9	86	2	PS50821
Domain	PAZ	AGO1 PIWIL3	7.39e-04	9	86	2	SM00949
Domain	PAZ_dom	AGO1 PIWIL3	7.39e-04	9	86	2	IPR003100
Domain	PAZ	AGO1 PIWIL3	7.39e-04	9	86	2	PF02170
Domain	ThiF_NAD_FAD-bd	MOCS3 UBA6	9.21e-04	10	86	2	IPR000594
Domain	ThiF	MOCS3 UBA6	9.21e-04	10	86	2	PF00899
Domain	FAD-dep_OxRdtase	PIPOX SARDH	1.34e-03	12	86	2	IPR006076
Domain	DAO	PIPOX SARDH	1.34e-03	12	86	2	PF01266
Domain	-	PYROXD2 PIPOX SARDH	2.19e-03	56	86	3	3.50.50.60
Domain	FAD/NAD-binding_dom	PYROXD2 PIPOX SARDH	2.31e-03	57	86	3	IPR023753
Domain	FHA_DOMAIN	TIFAB TIFA	8.94e-03	31	86	2	PS50006
Domain	FHA	TIFAB TIFA	8.94e-03	31	86	2	PF00498
Pubmed	Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism.	ACOT1 ACOT2 ACOT4	1.46e-08	3	86	3	10567408
Pubmed	Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.	ACOT1 ACOT2 ACOT4	5.83e-08	4	86	3	15007068
Pubmed	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.	ACOT1 ACOT2 ACOT4	1.45e-07	5	86	3	16940157
Pubmed	A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.	ACOT1 ACOT2 ACOT4	1.21e-06	9	86	3	16103133
Pubmed	In silico studies on the comparative characterization of the interactions of SARS-CoV-2 spike glycoprotein with ACE-2 receptor homologs and human TLRs.	ACE2 TLR4	6.04e-06	2	86	2	32383269
Pubmed	Exogenous tumor necrosis factor alpha and interleukin-1 alpha increase resistance to Salmonella typhimurium: efficacy is influenced by the Ity and Lps loci.	SLC11A1 TLR4	6.04e-06	2	86	2	7622247
Pubmed	Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism.	ACOT1 ACOT2	6.04e-06	2	86	2	11330065
Pubmed	TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease.	TIFAB TIFA	6.04e-06	2	86	2	32910997
Pubmed	Incremental expression of Tlr4 correlates with mouse resistance to Salmonella infection and fine regulation of relevant immune genes.	SLC11A1 TLR4	6.04e-06	2	86	2	16738669
Pubmed	Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.	ACOT1 ACOT2	6.04e-06	2	86	2	25114170
Pubmed	Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.	SLC11A1 TLR4	6.04e-06	2	86	2	6985638
Pubmed	COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation.	ACE2 TLR4	6.04e-06	2	86	2	33505220
Pubmed	TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.	HIC1 AGO1 FAM120A AKAP8 KPRP SEPTIN7 ATP5F1A	1.42e-05	317	86	7	30997501
Pubmed	Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.	ACOT1 ACOT2	1.81e-05	3	86	2	35215835
Pubmed	Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.	ARHGAP4 OR51B5	1.81e-05	3	86	2	36288877
Pubmed	MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica.	SLC11A1 TLR4	1.81e-05	3	86	2	11261784
Pubmed	Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase.	ACOT2 ACOT4	1.81e-05	3	86	2	10944470
Pubmed	Leptin and insulin do not exert redundant control of metabolic or emotive function via dopamine neurons.	SLC6A3 INSR	1.81e-05	3	86	2	30292429
Pubmed	Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression.	ACOT1 ACOT2	1.81e-05	3	86	2	31930115
Pubmed	Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata.	SLC11A1 TLR4	1.81e-05	3	86	2	12625509
Pubmed	TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain.	TIFAB TIFA	1.81e-05	3	86	2	15047173
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RANBP10 AGO1 FAM120A AKAP8 UBA6 SYNPO ADGRA1 SEPTIN7 TOP3B LDB2 CNTN1	2.55e-05	963	86	11	28671696
Pubmed	TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.	TIFAB TIFA	3.61e-05	4	86	2	32101751
Pubmed	Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: the proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4.	TLR4 HSPB2	3.61e-05	4	86	2	24918749
Pubmed	Efficacy of Resistance to Francisella Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.	SLC11A1 TLR4	3.61e-05	4	86	2	28360906
Pubmed	TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release.	TLR4 TIFA	3.61e-05	4	86	2	23722163
Pubmed	Female reproductive tract has low concentration of SARS-CoV2 receptors.	ACE2 CTSB	3.61e-05	4	86	2	33315943
Pubmed	Cell-based receptor discovery identifies host factors specifically targeted by the SARS CoV-2 spike.	ACE2 CNTN1	6.01e-05	5	86	2	35931765
Pubmed	Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction.	SLC11A1 TLR4	6.01e-05	5	86	2	19720755
Pubmed	The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway.	FAT1 UBA6	6.01e-05	5	86	2	22347407
Pubmed	Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.	ACOT1 ACOT2	6.01e-05	5	86	2	31676684
Pubmed	Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.	INSR FGFR1	9.01e-05	6	86	2	8559144
Pubmed	Fine-tuning nucleophosmin in macrophage differentiation and activation.	TLR4 CTSB	9.01e-05	6	86	2	21876121
Pubmed	The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice.	SLC11A1 TLR4	9.01e-05	6	86	2	12055258
Pubmed	Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome.	SLC11A1 CTSB	9.01e-05	6	86	2	9034150
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ARHGAP4 FAT1 FAM120A AKAP8 RBBP6 MBD1 ASH1L BCKDHB TEP1 KAT14 PARS2	9.59e-05	1116	86	11	31753913
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	MEMO1 MBD1 AUTS2 SYNPO KBTBD7 ATP5F1A HSPB2	9.90e-05	431	86	7	33660365
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	MARS2 FLAD1 PYROXD2 BCKDHB ACOT1 ACOT2 SARDH TRMT61B HIBADH ATP5F1A PARS2	1.12e-04	1136	86	11	34800366
Pubmed	A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.	SLC6A3 ATP5F1A	1.26e-04	7	86	2	31704785
Pubmed	Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.	SLC6A3 FAT1	1.26e-04	7	86	2	32142670
Pubmed	Toll-like receptor-deficient mice reveal how innate immune signaling influences Salmonella virulence strategies.	SLC11A1 TLR4	1.26e-04	7	86	2	24528866
Pubmed	Novel insight in the association between salmonellosis or campylobacteriosis and chronic illness, and the role of host genetics in susceptibility to these diseases.	SLC11A1 TLR4	1.26e-04	7	86	2	18062835
Pubmed	The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.	INSR FGFR1	1.26e-04	7	86	2	12783862
Pubmed	TLR signaling is required for Salmonella typhimurium virulence.	SLC11A1 TLR4	1.26e-04	7	86	2	21376231
Pubmed	Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia.	TLR4 CTSB	1.68e-04	8	86	2	31611307
Pubmed	Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation.	TLR4 CTSB	1.68e-04	8	86	2	22916010
Pubmed	A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.	PIPOX ACOT2 ACOT4	1.80e-04	44	86	3	20178365
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	MEMO1 CLIP3 HOXB6 AKAP8 SZT2 FAXDC2 SYNPO SEPTIN7 ELFN2 HIF1AN	2.14e-04	1021	86	10	26760575
Pubmed	Identification of eight members of the Argonaute family in the human genome.	AGO1 PIWIL3	2.15e-04	9	86	2	12906857
Pubmed	Disruption of FAT10-MAD2 binding inhibits tumor progression.	FAT1 UBA6	2.68e-04	10	86	2	25422469
Pubmed	A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.	ACE2 TLR4	2.68e-04	10	86	2	32726802
Pubmed	Isolation of tyrosine kinase related genes expressed in the early hematopoietic system.	INSR FGFR1	2.68e-04	10	86	2	8034026
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FAM120A AKAP8 MBD1 TOP3B HIF1AN KBTBD7 GTF3C5 PARS2 LDB2	2.72e-04	857	86	9	25609649
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	CCPG1 AGO1 ACOT1 ACOT2 ANKZF1	2.90e-04	233	86	5	37704626
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	HOXB6 MBD1 ASH1L POLR1B SOX8 ANKZF1 HIF1AN GTF3C5 LDB2	3.21e-04	877	86	9	20211142
Pubmed	A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.	AUTS2 CNTN1	3.28e-04	11	86	2	22925353
Pubmed	Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.	FAH HIBADH ATP5F1A HSPB2	3.31e-04	132	86	4	22496890
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	MARS2 FAT1 CCPG1 FAM120A RBBP6 ACOT1 SEPTIN7 ANKZF1 CTSB TOP3B ATP5F1A	3.51e-04	1297	86	11	33545068
Pubmed	Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.	ACOT2 ACOT4	3.93e-04	12	86	2	7596406
Pubmed	Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.	SLC6A3 TSHB	3.93e-04	12	86	2	9247269
Pubmed	Nontuberculous mycobacterial cervicofacial lymphadenitis in children from the multicenter, randomized, controlled trial in The Netherlands: relevance of polymorphisms in candidate host immunity genes.	SLC11A1 TLR4	3.93e-04	12	86	2	20399512
Pubmed	Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.	SLC11A1 TLR4	3.93e-04	12	86	2	19723394
Pubmed	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	AGO1 MBD1 TLR4 ATP5F1A	4.14e-04	140	86	4	20819778
Pubmed	Regulation of error-prone translesion synthesis by Spartan/C1orf124.	FAM120A SPRTN ATP5F1A	4.29e-04	59	86	3	23254330
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	HIC1 ST7 TLR4 ASH1L CTSB	4.53e-04	257	86	5	30945288
Pubmed	Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.	TLR4 FGFR1	5.39e-04	14	86	2	18559345
Pubmed	Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.	MARS2 PARS2	5.39e-04	14	86	2	15779907
Pubmed	A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.	TLR4 FGFR1 ATP5F1A	5.97e-04	66	86	3	32212902
Pubmed	GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.	FAM120A UBA6	6.21e-04	15	86	2	31417184
Pubmed	Identification of potential protein interactors of Lrrk2.	AGO1 AKAP8	6.21e-04	15	86	2	17400507
Pubmed	Structure, chromosome mapping, and expression of the mouse Lyl-1 gene.	INSR FGFR1	6.21e-04	15	86	2	2067848
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	SLC6A3 TLR4 INSR TEP1 CTSB HIF1AN	6.31e-04	421	86	6	19692168
Pubmed	Functional proteomics mapping of a human signaling pathway.	CPXM2 RBBP6 MBD1 ASH1L UBA6 SPRTN LDB2	6.66e-04	591	86	7	15231748
Pubmed	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	PIPOX ACOT4	7.09e-04	16	86	2	14561759
Pubmed	Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.	TSHB TEP1	1.01e-03	19	86	2	14671302
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HOXB6 LMF1 FAM120A ST7 INSR TMEM212 ASH1L UBA6 AUTS2 SYNPO TEP1	1.10e-03	1489	86	11	28611215
Pubmed	An Ideal PPAR Response Element Bound to and Activated by PPARα.	ACOT1 ACOT2	1.12e-03	20	86	2	26241474
Pubmed	TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.	HIC1 FGFR1	1.12e-03	20	86	2	36542062
Pubmed	FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.	HOXB6 FGFR1	1.23e-03	21	86	2	16207751
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FAM120A MBD1 ASH1L SYNPO ACOT1 TRIM68 SEPTIN7 CTSB ATP5F1A LDB2	1.27e-03	1285	86	10	35914814
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	KPRP BCKDHB ACOT1 SEPTIN7 CTSB HIBADH ATP5F1A PARS2	1.30e-03	859	86	8	31536960
Pubmed	Genome-wide, large-scale production of mutant mice by ENU mutagenesis.	FGFR1 OTOG	1.35e-03	22	86	2	10932192
Pubmed	ZBTB20 is required for anterior pituitary development and lactotrope specification.	SLC6A3 TSHB	1.48e-03	23	86	2	27079169
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	MARS2 AKAP8 FLAD1 BCKDHB ACOT1 HIBADH PARS2	1.58e-03	686	86	7	28380382
Pubmed	Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo.	SLC6A3 FGFR1	1.61e-03	24	86	2	22537018
Pubmed	Fgfr2 is required for the expansion of the early adrenocortical primordium.	INSR FGFR1	1.61e-03	24	86	2	26141512
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ARHGAP4 FAT1 CCPG1 ST7 ASH1L SYNPO OTOG	1.61e-03	689	86	7	36543142
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	ACOT1 ACOT2 SARDH HIBADH ATP5F1A	1.64e-03	343	86	5	28130547
Pubmed	The protein interaction landscape of the human CMGC kinase group.	AMMECR1L AKAP8 RBBP6 INSR FGFR1 GPATCH8 CTSB	1.70e-03	695	86	7	23602568
Pubmed	Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.	INSR FGFR1	1.75e-03	25	86	2	15254900
Pubmed	Mouse oocytes develop in cysts with the help of nurse cells.	CTSB ATP5F1A	1.89e-03	26	86	2	35623357
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	IER5L MOCS3 ALG9 TIFA ACP4 SOX8 ELFN2 KAT14	1.94e-03	915	86	8	32393512
Pubmed	Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia.	TSHB FGFR1	2.04e-03	27	86	2	29796621
Pubmed	The LIFEdb database in 2006.	ARHGAP4 ALG9 UBA6 SYNPO TRIM68 SPRTN KBTBD7	2.07e-03	720	86	7	16381901
Pubmed	From ORFeome to biology: a functional genomics pipeline.	ARHGAP4 ALG9 UBA6 SYNPO TRIM68 SPRTN KBTBD7	2.10e-03	722	86	7	15489336
Pubmed	A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE).	HOXB6 HABP2	2.19e-03	28	86	2	17683524
Pubmed	Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.	SKIDA1 AUTS2	2.19e-03	28	86	2	33953184
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	LMF1 FAM120A AKAP8 ALG9 POLR1B GPATCH8 GTF3C5	2.29e-03	733	86	7	34672954
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	ACOT1 ACOT2 SARDH CTSB HIBADH ATP5F1A	2.29e-03	542	86	6	14651853
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	ACOT1 ACOT2	2.35e-03	29	86	2	28364022
GeneFamily	Acyl-CoA thioesterases	ACOT1 ACOT2 ACOT4	2.50e-06	10	51	3	41
GeneFamily	Argonaute/PIWI family	AGO1 PIWIL3	2.16e-04	8	51	2	408
GeneFamily	Ubiquitin like modifier activating enzymes	MOCS3 UBA6	3.46e-04	10	51	2	100
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLIP3 LMF1 ADGRA1 FGFR1 SOX8 CSMD3 CNTN1	1.29e-07	199	87	7	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLIP3 LMF1 ADGRA1 FGFR1 SOX8 CSMD3 CNTN1	1.29e-07	199	87	7	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLIP3 LMF1 ADGRA1 FGFR1 SOX8 CSMD3 CNTN1	1.34e-07	200	87	7	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLIP3 ADGRA1 FGFR1 SOX8 CSMD3 CNTN1	2.60e-06	199	87	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	PND01-Immune-Immune_Myeloid-DC-cDC2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP4 TIFAB SZT2 FLAD1 TEP1	1.22e-05	152	87	5	cefc0ab592e99badf145fb95adf9906cb81be81c
ToppCell	PND01-Immune-Immune_Myeloid-DC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP4 TIFAB SZT2 FLAD1 TEP1	1.22e-05	152	87	5	c8faa83dcaddb2ce2bb890f90dd8e676f7dcb1b3
ToppCell	PND01-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP4 TIFAB SZT2 FLAD1 TEP1	1.22e-05	152	87	5	c3f00beb8b6fde99263d5ed6bbe3c2415d02f91d
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 TIFAB IER5L TLR4 CTSB	1.47e-05	158	87	5	d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 TIFAB IER5L TLR4 CTSB	1.47e-05	158	87	5	df614450e10629dc9115d7365397663e82f9e48f
ToppCell	droplet-Lung-21m-Hematologic-myeloid\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC11A1 TIFAB TIFA TEP1 CTSB	2.15e-05	171	87	5	22ad6de44e1d3f72a3d78d46fd26a5743a4f84a5
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPNE2 TIFAB TIFA FGFR1 TEP1	2.47e-05	176	87	5	7d1e2627d7ec5ddd6c87c55d2a6879255b76949e
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAH PIPOX HABP2 ACOT4 SARDH	3.05e-05	184	87	5	3d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAH PIPOX HABP2 ACOT4 SARDH	3.05e-05	184	87	5	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	PBMC-Severe-cDC_0\|Severe / Compartment, Disease Groups and Clusters	CPNE2 SLC11A1 IER5L TLR4 CTSB	3.74e-05	192	87	5	4f4774b925058191673b4ba4b4d05b8b37f61795
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC11A1 IER5L RBBP6 TLR4 CTSB	4.33e-05	198	87	5	93cc01d91ffc543fd1a717ef47e02e532b50b665
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 IER5L ACOT1 FGFR1 ACOT2	4.33e-05	198	87	5	8d7eb43b3e3b4a15265985143991e42afc20dc85
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	FAM120A RBBP6 MBD1 INSR TMEM212	4.43e-05	199	87	5	61b1ed2db71b96157b92b7535d1955a4033098da
Drug	rofecoxib; Down 200; 10uM; MCF7; HG-U133A	SLC6A3 RANBP10 SLC11A1 MBD1 PIPOX SYNPO FGFR1 CNTN1	7.03e-07	198	84	8	205_DN
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A	LMF1 SZT2 TMEM212 ASH1L FAXDC2 BCKDHB CNTN1	8.14e-06	196	84	7	5488_UP
Drug	Sulfaguanidine [57-67-0]; Down 200; 18.6uM; HL60; HG-U133A	ARHGAP4 RANBP10 AKAP8 MBD1 FGFR1 HIF1AN GTF3C5	8.14e-06	196	84	7	1995_DN
Disease	diabetes mellitus (is_implicated_in)	TLR4 INSR CTSB	7.44e-05	29	83	3	DOID:9351 (is_implicated_in)
Disease	dodecadienoate (12:2) measurement	ACOT2 ACOT4	7.77e-05	5	83	2	EFO_0800572
Disease	X-16935 measurement	ACOT2 ACOT4	1.63e-04	7	83	2	EFO_0800763
Disease	X-24747 measurement	ACOT2 ACOT4	2.16e-04	8	83	2	EFO_0022135
Disease	Disorder of amino acid metabolism	FAH BCKDHB	2.16e-04	8	83	2	cv:C0002514
Disease	high grade glioma (implicated_via_orthology)	INSR FGFR1 CTSB	2.62e-04	44	83	3	DOID:3070 (implicated_via_orthology)
Disease	X-17653 measurement	ACOT2 ACOT4	2.78e-04	9	83	2	EFO_0800783
Disease	respiratory syncytial virus infectious disease (is_implicated_in)	ACE2 TLR4	3.47e-04	10	83	2	DOID:1273 (is_implicated_in)
Disease	undecenoylcarnitine (C11:1) measurement	ACOT2 ACOT4	5.98e-04	13	83	2	EFO_0800588
Disease	Diabetic Asymmetric Polyneuropathy	TLR4 INSR	6.96e-04	14	83	2	C0393835
Disease	Diabetic Neuralgia	TLR4 INSR	6.96e-04	14	83	2	C0751074
Disease	Diabetic Neuropathies	TLR4 INSR	6.96e-04	14	83	2	C0011882
Disease	Asymmetric Diabetic Proximal Motor Neuropathy	TLR4 INSR	6.96e-04	14	83	2	C0271674
Disease	Symmetric Diabetic Proximal Motor Neuropathy	TLR4 INSR	6.96e-04	14	83	2	C0271673
Disease	Diabetic Mononeuropathy	TLR4 INSR	6.96e-04	14	83	2	C0271678
Disease	Diabetic Autonomic Neuropathy	TLR4 INSR	6.96e-04	14	83	2	C0271686
Disease	Diabetic Amyotrophy	TLR4 INSR	6.96e-04	14	83	2	C0271685
Disease	Diabetic Polyneuropathies	TLR4 INSR	6.96e-04	14	83	2	C0271680
Disease	diabetic neuropathy (implicated_via_orthology)	TLR4 INSR	6.96e-04	14	83	2	DOID:9743 (implicated_via_orthology)
Disease	inferior parietal cortex volume measurement	OR51B5 CPXM2	1.30e-03	19	83	2	EFO_0010307
Disease	Giant Cell Glioblastoma	FAT1 FGFR1 CTSB	1.74e-03	84	83	3	C0334588
Disease	amblyopia	TLR4 BCKDHB	1.74e-03	22	83	2	MONDO_0001020
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	TLR4 CTSB	2.43e-03	26	83	2	DOID:0080998 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PETGHYIEPPYFPLC	ACOT1	356	Q86TX2
YIEPPYFPLCRASLH	ACOT1	361	Q86TX2
PRPHYAQPGCVYFIC	ASH1L	2641	Q9NR48
CLPHIRFYGPTNFSP	CPNE2	401	Q96FN4
LYCHLYGFPQPRLPR	AMMECR1L	116	Q6DCA0
GLYESHVGCRPYSIP	CTSB	171	P07858
AFYCSTPESPPHGYI	CSMD3	2566	Q7Z407
SRPCLPEHNPYRPSY	AKAP8	136	O43823
ALFRGYHGPLDLYPE	ALG9	431	Q9H6U8
GRSFFSPPEGYYHPL	AGO1	176	Q9UL18
RYPGEFLHPVVYACT	ADGRA1	11	Q86SQ6
GHYIEPPYFPLCRAS	ACOT2	421	P49753
PPGREAYPGDVFYLH	ATP5F1A	331	P25705
LGCPLPDPNNYYHRR	CPXM2	291	Q8N436
RATHPIPAACGIYYF	RANBP10	91	Q6VN20
CGYDTPFPHIFEPFY	BCKDHB	361	P21953
TCREPHAPYPPGYQR	FAT1	4511	Q14517
PTLYHGYYVRPRAAP	HSPB2	41	Q16082
PDQFECLYPYPVHHP	HIF1AN	221	Q9NWT6
LEGYPCPHLAYGEPE	HIC1	416	Q14526
FLPYYPPDSEARRPC	ERN2	906	Q76MJ5
HDPFYSSPFGPFYRR	LDB2	6	O43679
RALAPSPPAEFIYYC	MBD1	306	Q9UIS9
DCYPGDPTISHNYLP	GPATCH8	1231	Q9UKJ3
PPIRPLYFFLYCHSH	OR51B5	156	Q9H339
APLDYCYVRPNHIPT	KAT14	636	Q9H8E8
VDPFYRHSLFHSYPP	AUTS2	571	Q8WXX7
SYLPSLPHPAYFGLA	SLC11A1	486	P49279
PALPFYPASAYPRHF	FAM120A	861	Q9NZB2
DGRCVETCPPPYYHF	INSR	261	P06213
HPRDPFLCYDPYSGD	KBTBD7	351	Q8WVZ9
PPSYTCFRCGKPGHY	RBBP6	156	Q7Z6E9
PLYSSGYADPLRHYP	HOXB6	26	P17509
LYDGHTPPYAACLGF	ACP4	301	Q9BZG2
PPYYRCVCKHPYTGP	HABP2	131	Q14520
SHCGYHLPFLPSPEF	FAXDC2	261	Q96IV6
PYGPRSVYIKPCHYS	CCPG1	741	Q9ULG6
YAYRCVLGPHQDPPE	ANKZF1	176	Q9H8Y5
GSSMHPYCPFPLGYL	DMRTB1	211	Q96MA1
RRPPGLEYCYNPSHN	FGFR1	576	P11362
LLCDPPYHFPDDLSY	CNTN1	156	Q12860
AYPSYISPIGCLPAH	ACE2	251	Q9BYF1
PYCHKPCYGALFGPR	CRIP3	51	Q6Q6R5
IYCPHYGAPLPPAER	EFNA2	71	O43921
SYLPLRPSEGFPNYC	KPRP	281	Q5T749
SYRSRFCHPIYFPPR	KRTAP13-3	141	Q3SY46
PRPLPYLCHDEPYTF	FAH	281	P16930
YFTCPPRHGVFAPAS	CLIP3	466	Q96DZ5
CLSPGGHPTYRPAYL	FLAD1	561	Q8NFF5
YNLPGIIRVPAPCHY	PIWIL3	841	Q7Z3Z3
YRGAYPTPSDFGLHC	IER5L	236	Q5T953
HYDGGPCYRCIFPQP	MOCS3	216	O95396
PPFDACHAYVSPLPF	OTOG	356	Q6ZRI0
PARAIIAPHAGYTYC	MEMO1	41	Q9Y316
YPASPGCYHLLPYTV	PARS2	81	Q7L3T8
PSNPHYFFYCPPSSR	SZT2	1451	Q5T011
PHRPIPEYGTYSLCS	TIFA	156	Q96CG3
LLLPYLSYFHCDDPP	SPATA31A6	41	Q5VVP1
ARTPPASLYHGYLPE	SYNPO	781	Q8N3V7
CTLYFPFYCGLIPPE	PNPLA5	146	Q7Z6Z6
GRCPYALLHPHPLRY	FOXD4L5	256	Q5VV16
YPGSHYPEIVRSPCK	SKIDA1	176	Q1XH10
GLYQYPCFHSPRRPY	SOX8	401	P57073
PLEKGHLFYPYPICT	ST7	476	Q9NRC1
ATVFCPPLRFDYHPH	ARHGAP4	326	P98171
FHPRGPAPVLEYDYY	SARDH	511	Q9UL12
HGYPLIIYDVFPDAC	HIBADH	61	P31937
YIEPPYFPLCPASLH	ACOT4	361	Q8N9L9
RGKSYPLCPYCYNHP	TOP3B	681	O95985
PLCPYCYNHPPFRDM	TOP3B	686	O95985
EDLPGPPVRYYFSHD	UBA6	1036	A0AVT1
DCGSHIFTFPRYPFP	TRIM68	441	Q6AZZ1
YPYAKFPLACVDPPH	TMEM212	126	A6NML5
FPLACVDPPHYEEYH	TMEM212	131	A6NML5
HSDFPYGSFPYVARP	TRMT61B	441	Q9BVS5
EPPFSHRCFPRYIGF	TEP1	401	Q99973
YFARPVPLHSGYRCP	PYROXD2	531	Q8N2H3
FLTDLYSPEYPGPSH	SEPTIN7	71	Q16181
VTFRPPHYGAYIFPD	SLC6A3	541	Q01959
VCYFHVSPSPLIYRP	TIFAB	126	Q6ZNK6
LYFLPRFYGHPCPFE	MARS2	551	Q96GW9
GPCQHRPPYYGYVKR	SPRTN	171	Q9H040
GCPLHVAPYFSYPVA	TSHB	86	P01222
LCPHHIYGLPTGEYP	PIPOX	251	Q9P0Z9
ELYFRPKDPYCHPVC	GTF3C5	61	Q9Y5Q8
PIDGAPHRSYSECYP	POLR1B	541	Q9H9Y6
PPFQLCLHYRDFIPG	TLR4	701	O00206
RKYSHYCLPPRAPGS	TMEM271	151	A0A286YF58
FAGYPLLVPRPYHSL	ELFN2	221	Q5R3F8
GDPSRRPCLISPYHY	LMF1	446	Q96S06