Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	CACNA1E DCHS2 PADI4 ENPP2 FAT3 PCDHAC1 CRELD2 DLL1 ZZEF1 TBC1D9 CLEC4E FBN1 FBN2 LRP4 RASGRP2	1.10e-04	749	130	15	GO:0005509
GeneOntologyBiologicalProcess	cell fate specification	MYT1L SOX6 CHD4 DLL1 PAX6 MGA NODAL	1.37e-05	123	131	7	GO:0001708
GeneOntologyBiologicalProcess	podocyte cell migration	KANK2 WDPCP KANK1	1.37e-05	8	131	3	GO:0090521
GeneOntologyBiologicalProcess	positive regulation of presynaptic membrane organization	APOE LRP4	4.00e-05	2	131	2	GO:1901631
GeneOntologyBiologicalProcess	eye development	CACNA1F FAT3 ABCB5 IKZF1 DLL1 WDPCP CRYGB CLCN2 VHLL MFSD8 PAX6 PROX1	5.71e-05	480	131	12	GO:0001654
GeneOntologyBiologicalProcess	visual system development	CACNA1F FAT3 ABCB5 IKZF1 DLL1 WDPCP CRYGB CLCN2 VHLL MFSD8 PAX6 PROX1	6.06e-05	483	131	12	GO:0150063
GeneOntologyBiologicalProcess	retina development in camera-type eye	CACNA1F FAT3 IKZF1 DLL1 CLCN2 MFSD8 PAX6 PROX1	6.19e-05	211	131	8	GO:0060041
GeneOntologyBiologicalProcess	sensory system development	CACNA1F FAT3 ABCB5 IKZF1 DLL1 WDPCP CRYGB CLCN2 VHLL MFSD8 PAX6 PROX1	7.08e-05	491	131	12	GO:0048880
GeneOntologyBiologicalProcess	columnar/cuboidal epithelial cell differentiation	CDKN1A DLL1 CLCN2 VHLL PAX6 NODAL PROX1	8.64e-05	164	131	7	GO:0002065
GeneOntologyBiologicalProcess	camera-type eye development	CACNA1F FAT3 IKZF1 DLL1 WDPCP CRYGB CLCN2 VHLL MFSD8 PAX6 PROX1	8.84e-05	426	131	11	GO:0043010
GeneOntologyBiologicalProcess	regulation of timing of cell differentiation	DLL1 PAX6 NODAL	1.08e-04	15	131	3	GO:0048505
GeneOntologyBiologicalProcess	negative regulation of cell cycle process	CDKN1A ATRX RAD9B TERF2 TRRAP KANK2 BLM FANCD2 HASPIN PROX1	1.08e-04	362	131	10	GO:0010948
GeneOntologyBiologicalProcess	camera-type eye morphogenesis	FAT3 IKZF1 DLL1 CRYGB VHLL PAX6 PROX1	1.12e-04	171	131	7	GO:0048593
GeneOntologyBiologicalProcess	regulation of presynaptic membrane organization	APOE LRP4	1.20e-04	3	131	2	GO:1901629
GeneOntologyBiologicalProcess	cellular response to ionizing radiation	CDKN1A RAD9B BLM EEF1D FIGNL1	1.23e-04	76	131	5	GO:0071479
GeneOntologyBiologicalProcess	regulation of development, heterochronic	DLL1 PAX6 NODAL	1.60e-04	17	131	3	GO:0040034
GeneOntologyBiologicalProcess	tube development	CDKN1A ATRX SGCD NUMA1 TSC1 APOE DLL1 WDPCP RNF220 FBN1 CLCN2 PIK3C2A PKM VHLL PAX6 C6 LZTS2 NODAL JAM3 ALPI PROX1	2.00e-04	1402	131	21	GO:0035295
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	2.38e-04	4	131	2	GO:0035583
GeneOntologyBiologicalProcess	cell fate determination	DLL1 IFRD1 PAX6 PROX1	2.85e-04	50	131	4	GO:0001709
GeneOntologyBiologicalProcess	glandular epithelial cell differentiation	DLL1 CLCN2 VHLL PAX6 PROX1	2.88e-04	91	131	5	GO:0002067
GeneOntologyBiologicalProcess	neural tube development	TSC1 WDPCP RNF220 PAX6 NODAL ALPI PROX1	3.12e-04	202	131	7	GO:0021915
GeneOntologyBiologicalProcess	cell fate commitment	MYT1L SOX6 CHD4 DLL1 IFRD1 PAX6 MGA NODAL PROX1	3.14e-04	338	131	9	GO:0045165
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection organization	MYCBP2 KIF26A ENPP2 SYNE1 FAT3 TSC1 APOE WDPCP IFRD1 KANK1 TENM1 LRP4 PAX6 ROBO3 ATP1B2	3.15e-04	846	131	15	GO:0120035
GeneOntologyBiologicalProcess	ameboidal-type cell migration	ENPP2 MCC APOE KANK2 WDPCP KANK1 FBN2 PIK3C2A VHLL PAX6 NODAL PROX1	3.16e-04	577	131	12	GO:0001667
GeneOntologyBiologicalProcess	eye morphogenesis	FAT3 IKZF1 DLL1 CRYGB VHLL PAX6 PROX1	3.31e-04	204	131	7	GO:0048592
GeneOntologyBiologicalProcess	neuron development	MYT1L CACNA1F MYCBP2 KIF26A SYNE1 FAT3 TSC1 APOE WDPCP NCDN RNF157 RNF220 IFRD1 KANK1 OTOGL TENM1 LRP4 MFSD8 PAX6 ROBO3 ATP1B2	3.56e-04	1463	131	21	GO:0048666
GeneOntologyBiologicalProcess	regulation of cell projection organization	MYCBP2 KIF26A ENPP2 SYNE1 FAT3 TSC1 APOE WDPCP IFRD1 KANK1 TENM1 LRP4 PAX6 ROBO3 ATP1B2	3.88e-04	863	131	15	GO:0031344
GeneOntologyBiologicalProcess	oligodendrocyte cell fate commitment	SOX6 PAX6	3.95e-04	5	131	2	GO:0021779
GeneOntologyBiologicalProcess	oligodendrocyte cell fate specification	SOX6 PAX6	3.95e-04	5	131	2	GO:0021778
GeneOntologyBiologicalProcess	negative regulation of mitotic recombination	TERF2 BLM	3.95e-04	5	131	2	GO:0045950
GeneOntologyBiologicalProcess	acinar cell differentiation	CLCN2 PROX1	3.95e-04	5	131	2	GO:0090425
GeneOntologyBiologicalProcess	response to ionizing radiation	CDKN1A RAD9B BLM FANCD2 EEF1D FIGNL1	4.11e-04	151	131	6	GO:0010212
GeneOntologyBiologicalProcess	animal organ morphogenesis	SOX6 FAT3 IKZF1 MDM4 DLL1 WDPCP FANCD2 CRYGB FBN2 GLG1 VHLL LRP4 ELF3 PAX6 KLK5 FGL1 LZTS2 NODAL PROX1	4.18e-04	1269	131	19	GO:0009887
GeneOntologyBiologicalProcess	cell cycle checkpoint signaling	CDKN1A RAD9B TRRAP BLM FANCD2 HASPIN PROX1	4.80e-04	217	131	7	GO:0000075
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	GNL3L MYCBP2 ENPP2 SYNE1 NUMA1 TSC1 IKZF1 CHD4 APOE TERF2 KANK2 WDPCP BID KANK1 KANK3 TENM1 LRP4 JAM3	5.27e-04	1189	131	18	GO:0044087
GeneOntologyBiologicalProcess	regulation of neuron projection development	MYCBP2 KIF26A SYNE1 FAT3 TSC1 APOE IFRD1 KANK1 LRP4 PAX6 ROBO3 ATP1B2	5.35e-04	612	131	12	GO:0010975
Domain	KN_motif	KANK2 KANK1 KANK3	1.37e-06	4	132	3	IPR021939
Domain	KN_motif	KANK2 KANK1 KANK3	1.37e-06	4	132	3	PF12075
Domain	APC_su10/DOC_dom	MYCBP2 ZZEF1 HERC2	1.18e-05	7	132	3	IPR004939
Domain	DOC	MYCBP2 ZZEF1 HERC2	1.18e-05	7	132	3	PS51284
Domain	ANAPC10	MYCBP2 ZZEF1 HERC2	1.18e-05	7	132	3	PF03256
Domain	APC10	MYCBP2 ZZEF1 HERC2	1.18e-05	7	132	3	SM01337
Domain	EGF_Ca-bd_CS	FAT3 CRELD2 DLL1 FBN1 FBN2 LRP4	6.49e-05	97	132	6	IPR018097
Domain	EGF_CA	FAT3 CRELD2 DLL1 FBN1 FBN2 LRP4	7.28e-05	99	132	6	PS01187
Domain	ASX_HYDROXYL	FAT3 CRELD2 DLL1 FBN1 FBN2 LRP4	7.70e-05	100	132	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT3 CRELD2 DLL1 FBN1 FBN2 LRP4	1.06e-04	106	132	6	IPR000152
Domain	FBN	FBN1 FBN2	1.48e-04	3	132	2	IPR011398
Domain	EGF_CA	FAT3 CRELD2 DLL1 FBN1 FBN2 LRP4	2.30e-04	122	132	6	SM00179
Domain	EGF-like_Ca-bd_dom	FAT3 CRELD2 DLL1 FBN1 FBN2 LRP4	2.51e-04	124	132	6	IPR001881
Domain	EGF_3	FAT3 CRELD2 DLL1 FBN1 FBN2 TENM1 LRP4 C6	2.69e-04	235	132	8	PS50026
Domain	EGF_CA	FAT3 CRELD2 FBN1 FBN2 LRP4	3.60e-04	86	132	5	PF07645
Domain	EGF-like_dom	FAT3 CRELD2 DLL1 FBN1 FBN2 TENM1 LRP4 C6	3.97e-04	249	132	8	IPR000742
Domain	EGF_1	FAT3 CRELD2 DLL1 FBN1 FBN2 TENM1 LRP4 C6	4.64e-04	255	132	8	PS00022
Domain	EGF-like_CS	FAT3 CRELD2 DLL1 FBN1 FBN2 TENM1 LRP4 C6	5.41e-04	261	132	8	IPR013032
Domain	EGF_2	FAT3 CRELD2 DLL1 FBN1 FBN2 TENM1 LRP4 C6	5.98e-04	265	132	8	PS01186
Domain	cEGF	FBN1 FBN2 LRP4	7.97e-04	26	132	3	PF12662
Domain	cEGF	FBN1 FBN2 LRP4	7.97e-04	26	132	3	IPR026823
Domain	TB	FBN1 FBN2	1.02e-03	7	132	2	PF00683
Domain	Ca_chan_IQ	CACNA1E CACNA1F	1.02e-03	7	132	2	SM01062
Domain	Ca_chan_IQ	CACNA1E CACNA1F	1.02e-03	7	132	2	PF08763
Domain	VDCC_a1su_IQ	CACNA1E CACNA1F	1.02e-03	7	132	2	IPR014873
Domain	GPHH	CACNA1E CACNA1F	1.02e-03	7	132	2	PF16905
Domain	GPHH_dom	CACNA1E CACNA1F	1.02e-03	7	132	2	IPR031649
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYT1L SOX6 DCHS2 VWF ATRX MYCBP2 ENPP2 SYNE1 CHD4 APOE KANK2 U2AF1 RNF220 FBN1 MTIF2 PKM LRP4 PAX6 HERC2 WDR17 XPOT	2.02e-08	1285	133	21	35914814
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GNL3L FXR2 FAT3 GPATCH2 MCC CHD4 ZZEF1 TRRAP KANK2 FANCD2 FBN2 TRAFD1 MTIF2 LRP4 ELF3 TAF5L LZTS2 MGA PROX1	5.44e-08	1116	133	19	31753913
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 DCHS2 GNL3L DUSP9 NUMA1 OBSCN TSC1 APOE TRRAP BLM TRAFD1 COPS7B XPOT	6.67e-08	497	133	13	36774506
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	GNL3L ATRX BAZ2B NUMA1 CHD4 TRRAP BLM LIG3 RNF220 ATAD2B SGO2 PAX6 HERC2 MGA	9.76e-08	608	133	14	36089195
Pubmed	Kank proteins: a new family of ankyrin-repeat domain-containing proteins.	KANK2 KANK1 KANK3	2.18e-07	4	133	3	17996375
Pubmed	Kank proteins: structure, functions and diseases.	KANK2 KANK1 KANK3	2.18e-07	4	133	3	19554261
Pubmed	Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.	CDKN1A DLL1 CRYGB PAX6 PROX1	3.00e-07	37	133	5	27631609
Pubmed	Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.	ENPP2 MDM4 KANK2 IFRD1 PAX6 TMCC1 CYTH4	3.57e-07	117	133	7	12107410
Pubmed	Chronic mTOR activation induces a degradative smooth muscle cell phenotype.	TSC1 APOE FBN1	5.44e-07	5	133	3	32039915
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ATRX MYCBP2 FXR2 NUMA1 GPATCH2 CHD4 TRRAP BLM HASPIN SGO2 HERC2	1.11e-06	440	133	11	34244565
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	VWF ATRX MYCBP2 FXR2 CRELD2 TSC1 TBC1D9 CYTIP FBN1 PKM LZTS2 GPSM1	1.77e-06	560	133	12	21653829
Pubmed	The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.	MYCBP2 TSC1 MAP3K12	1.89e-06	7	133	3	22798074
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	VWF MYCBP2 SGCD SYNE1 OBSCN LRRC2 CHD4 OSGEP PIK3C2A PKM MGA	3.58e-06	497	133	11	23414517
Pubmed	JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.	PAX6 JAM3 PROX1	4.52e-06	9	133	3	38095908
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	VWF FBN1 FBN2	4.52e-06	9	133	3	12122015
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ATRX NUMA1 CHD4 TERF2 TRRAP LIG3 HASPIN NLRC5 HERC2 MGA PROX1	6.94e-06	533	133	11	30554943
Pubmed	Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation.	CDKN1A PAX6 PROX1	8.82e-06	11	133	3	35472217
Pubmed	PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.	PIK3C2A PAX6 NODAL	8.82e-06	11	133	3	24697898
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.45e-05	2	133	2	30044367
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.45e-05	2	133	2	15131124
Pubmed	Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth.	CDKN1A MDM4	1.45e-05	2	133	2	14712235
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.45e-05	2	133	2	20404337
Pubmed	Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques.	APOE FBN1	1.45e-05	2	133	2	37120604
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.45e-05	2	133	2	8791520
Pubmed	T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2.	APOE PKM	1.45e-05	2	133	2	31480861
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.45e-05	2	133	2	7744963
Pubmed	Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.	IKZF1 CHD4	1.45e-05	2	133	2	22080921
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.45e-05	2	133	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.45e-05	2	133	2	18006876
Pubmed	Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy.	PADI4 APOE	1.45e-05	2	133	2	35923856
Pubmed	Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice.	APOE FBN1	1.45e-05	2	133	2	25797463
Pubmed	Impaired fibrillin-1 function promotes features of plaque instability in apolipoprotein E-deficient mice.	APOE FBN1	1.45e-05	2	133	2	19948973
Pubmed	HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis.	CDKN1A MDM4	1.45e-05	2	133	2	20062013
Pubmed	Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway.	CDKN1A APOE	1.45e-05	2	133	2	16908765
Pubmed	The NuRD complex-mediated p21 suppression facilitates chemoresistance in BRCA-proficient breast cancer.	CDKN1A CHD4	1.45e-05	2	133	2	28842166
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.45e-05	2	133	2	12524050
Pubmed	Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis.	CDKN1A APOE	1.45e-05	2	133	2	15596565
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.45e-05	2	133	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.45e-05	2	133	2	35419902
Pubmed	Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis.	VWF NFAT5	1.45e-05	2	133	2	24733925
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.45e-05	2	133	2	10504303
Pubmed	VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice.	PADI4 VWF	1.45e-05	2	133	2	24200682
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.45e-05	2	133	2	25524144
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.45e-05	2	133	2	16407178
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.45e-05	2	133	2	10359653
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.45e-05	2	133	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.45e-05	2	133	2	21851253
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.45e-05	2	133	2	21440062
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.45e-05	2	133	2	8307578
Pubmed	A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.	KANK2 KANK1	1.45e-05	2	133	2	31114072
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.45e-05	2	133	2	24833718
Pubmed	Inhibition of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation Reduces Angiotensin II-Induced Abdominal Aortic Aneurysm Rupture in Mice.	PADI4 APOE	1.45e-05	2	133	2	34395553
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.45e-05	2	133	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.45e-05	2	133	2	20529844
Pubmed	KANK family proteins in cancer.	KANK1 KANK3	1.45e-05	2	133	2	33309958
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.45e-05	2	133	2	23133647
Pubmed	NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration.	APOE NFAT5	1.45e-05	2	133	2	22934063
Pubmed	[Incidence of proapoptotic proteins p53 and p21 in epithelial ovarian tumors].	CDKN1A BID	1.45e-05	2	133	2	24745156
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.45e-05	2	133	2	1852206
Pubmed	Haploinsufficiency of E-selectin ligand-1 is associated with reduced atherosclerotic plaque macrophage content while complete deficiency leads to early embryonic lethality in mice.	APOE GLG1	1.45e-05	2	133	2	22939356
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.45e-05	2	133	2	12429739
Pubmed	Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability.	APOE TERF2	1.45e-05	2	133	2	26416809
Pubmed	BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.	BLM FANCD2	1.45e-05	2	133	2	15257300
Pubmed	Divergent JAM-C Expression Accelerates Monocyte-Derived Cell Exit from Atherosclerotic Plaques.	APOE JAM3	1.45e-05	2	133	2	27442505
Pubmed	PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis.	APOE PKM	1.45e-05	2	133	2	29732501
Pubmed	FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway.	BLM FANCD2	1.45e-05	2	133	2	27427384
Pubmed	Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background.	TSC1 BLM	1.45e-05	2	133	2	16288003
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	CDKN1A TSC1 PKM PAX6	1.68e-05	40	133	4	34677125
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GNL3L DDX49 MYCBP2 NUMA1 TSC1 CHD4 TRRAP BLM LIG3 EEF1D PIK3C2A SMU1 PKM HERC2 ALDH9A1 MGA XPOT	1.69e-05	1353	133	17	29467282
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E MYCBP2 FXR2 SYNE1 NUMA1 MCC TSC1 CHD4 KANK2 NCDN RIMBP2 HERC2 MGA PROX1	2.05e-05	963	133	14	28671696
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FXR2 DUSP9 MCC XPO4 OSGEP KANK2 FANCD2 FBN2 SMU1 LZTS2 ALDH9A1 GFM1 GPSM1 XPOT	2.33e-05	974	133	14	28675297
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ATRX NUMA1 CHD4 TRRAP LIG3 SMU1 XPOT	2.33e-05	220	133	7	35785414
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DUSP9 CHD4 MDM4 TRRAP KANK2 BLM PHKA2 LIG3 EEF1D IFRD1 PKM TAF5L MGA	2.66e-05	857	133	13	25609649
Pubmed	Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.	DLL1 PAX6 NODAL	2.95e-05	16	133	3	11900971
Pubmed	RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.	BLM LIG3 HERC2	2.95e-05	16	133	3	26474068
Pubmed	Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.	KANK2 KANK1 KANK3	2.95e-05	16	133	3	33253712
Pubmed	Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice.	CDKN1A IKZF1 PAX6	2.95e-05	16	133	3	28914974
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PRPSAP1 ATRX MYCBP2 FXR2 MCC XPO4 TSC1 OSGEP TRRAP U2AF1 LIG3 EEF1D SGO2 ELF3 HERC2 ALPI	3.36e-05	1284	133	16	17353931
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CDKN1A PRPSAP1 GNL3L FXR2 NUMA1 XPO4 CHD4 FANCD2 LIG3 EEF1D TRAFD1 PIK3C2A SMU1 LRP4 FIGNL1 ALPI XPOT	3.70e-05	1440	133	17	30833792
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	APOE FBN1 FBN2 PKM	4.11e-05	50	133	4	23658023
Pubmed	Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.	PADI4 APOE	4.34e-05	3	133	2	30140264
Pubmed	Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice.	TSC1 BLM	4.34e-05	3	133	2	16912167
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	4.34e-05	3	133	2	30201140
Pubmed	Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteins.	ATRX BLM	4.34e-05	3	133	2	22356911
Pubmed	The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.	MYCBP2 MAP3K12	4.34e-05	3	133	2	18031680
Pubmed	A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.	CDKN1A PKM	4.34e-05	3	133	2	27810895
Pubmed	SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.	XPO4 PKM	4.34e-05	3	133	2	26787900
Pubmed	Endothelial Cell-Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice.	VWF APOE	4.34e-05	3	133	2	29348121
Pubmed	HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN.	BLM HERC2	4.34e-05	3	133	2	33432007
Pubmed	ADAMTS13 modulates atherosclerotic plaque progression in mice via a VWF-dependent mechanism.	VWF APOE	4.34e-05	3	133	2	24261607
Pubmed	Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.	TERF2 BLM	4.34e-05	3	133	2	15229185
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	4.34e-05	3	133	2	10825173
Pubmed	Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia.	MYCBP2 IKZF1	4.34e-05	3	133	2	26517351
Pubmed	Deficiency of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 accelerates atherogenesis in apolipoprotein E-deficient mice.	CDKN1A APOE	4.34e-05	3	133	2	20417618
Pubmed	Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.	CDKN1A TERF2	4.34e-05	3	133	2	28912501
Pubmed	Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability.	TENM1 PAX6	4.34e-05	3	133	2	34388204
Pubmed	Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.	PADI4 APOE	4.34e-05	3	133	2	31043745
Pubmed	The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice.	APOE C6	4.34e-05	3	133	2	19959238
Pubmed	Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.	CDKN1A PKM	4.34e-05	3	133	2	29752805
Pubmed	The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.	PAX6 PROX1	4.34e-05	3	133	2	32594240
Interaction	FBXO22 interactions	CDKN1A BDP1 DCHS2 GNL3L DUSP9 NUMA1 OBSCN TSC1 APOE TRRAP BLM TRAFD1 COPS7B XPOT	1.05e-05	540	130	14	int:FBXO22
Interaction	POLR1G interactions	GNL3L DDX49 BAZ2B NUMA1 MCC TRRAP BLM LIG3 MTIF2 SGO2 LZTS2 MGA XPOT	1.71e-05	489	130	13	int:POLR1G
Interaction	MYH10 interactions	FXR2 NUMA1 MCC ZDBF2 CHD4 TERF2 WDFY4 FANCD2 CLEC4E HASPIN HERC2	2.16e-05	359	130	11	int:MYH10
Interaction	NBN interactions	ATRX NUMA1 MDM4 TERF2 BLM FANCD2 LIG3 LZTS2	2.51e-05	183	130	8	int:NBN
GeneFamily	Ankyrin repeat domain containing\|KN motif and ankyrin repeat domain containing	KANK2 KANK1 KANK3	4.60e-07	4	89	3	623
GeneFamily	Exportins	XPO4 XPOT	4.95e-04	7	89	2	547
Coexpression	GSE20727_CTRL_VS_H2O2_TREATED_DC_DN	MYCBP2 CHD4 DLL1 TERF2 PHKA2 WDR17 JAM3 PROX1	7.48e-06	196	133	8	M9243
Coexpression	GSE43700_UNTREATED_VS_IL10_TREATED_PBMC_UP	TSC1 GCGR CYTIP CRYGB IFRD1 ATAD2B TENM1 ELF3	8.66e-06	200	133	8	M9622
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000	SOX6 CDKN1A WSCD1 BDP1 ATRX FAT3 XPO4 IKZF1 ZDBF2 WDR54 DLL1 BLM IFRD1 USF3 MTIF2 ATAD2B PAX6 ROBO3 PROX1	1.05e-05	989	131	19	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	APOE WDFY4 TBC1D9 TRPV3 FCRL5 WDR17 BANK1	3.48e-07	150	133	7	4bdcdce40f54580c7a4e1416b468e657ba8874fc
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BAZ2B DUSP9 OBSCN IKZF1 CYTIP CLEC4E ROBO3	5.39e-07	160	133	7	237430af14830b38e58da8a4224036e5c6b71c5b
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 WDR54 APOE CYTIP USF3 COPS7B GPSM1	5.62e-07	161	133	7	3f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF2 SGCD GCGR TERF2 PIK3C2A RIMBP2 XPOT	9.47e-07	174	133	7	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	3'-Adult-SmallIntestine-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF2 MYCBP2 IKZF1 WDFY4 CYTIP FCRL5 BANK1	1.10e-06	178	133	7	da1695a936dbe3ca9ee3fb28ceb60511c47b35f8
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF2 MYCBP2 IKZF1 WDFY4 CYTIP FCRL5 BANK1	1.10e-06	178	133	7	580fc1d45b82010c665a313b2e7a21e0116819ef
ToppCell	PCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IKZF1 WDFY4 CYTIP NLRC5 BANK1 CYTH4 RASGRP2	1.43e-06	185	133	7	8fc357ee041bfd588986730a52ea2021b5f88941
ToppCell	background-B_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	IKZF1 WDFY4 FCRL5 FGL1 BANK1 CYTH4 RASGRP2	1.76e-06	191	133	7	a189fdc9c739bb0801e2f38af0932a1ea615cb34
ToppCell	3'-Adult-SmallIntestine\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX6 AFF2 ENPP2 IKZF1 FCRL5 BANK1 ALPI	2.17e-06	197	133	7	1614bc5f41fd2c8385e58ed6b87ef1536421f29a
ToppCell	Bronchus_Control_(B.)-Immune-TX-B_cells\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MYCBP2 IKZF1 CYTIP TRPV3 FCRL5 BANK1 RASGRP2	2.24e-06	198	133	7	6231c44a909dd06f85c8210814e976a5f29148d0
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 CYTIP FCRL5 BANK1 CYTH4 RASGRP2	2.24e-06	198	133	7	824461cf44098440ba8bc0df96735423ac65bda1
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 CYTIP FCRL5 BANK1 CYTH4 RASGRP2	2.24e-06	198	133	7	863765ccc0205dc28864dae85af339c283194c96
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	IKZF1 WDFY4 CYTIP MTIF2 FCRL5 BANK1 RASGRP2	2.32e-06	199	133	7	0eb8c72edcd34fe0f7ab9438c9c872d63576ef3a
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 ATRX SYNE1 MDM4 ATAD2B TENM1 NLRC5	2.32e-06	199	133	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	IKZF1 WDFY4 CYTIP MTIF2 FCRL5 BANK1 RASGRP2	2.32e-06	199	133	7	2cdc8ae6357723b9e7c0c66be656e6f748a6aa2d
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	IKZF1 WDFY4 TBC1D9 CYTIP MTIF2 BANK1 RASGRP2	2.39e-06	200	133	7	d124acbe5d46220850fe485ed78f032daddca5b1
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	IKZF1 WDFY4 TBC1D9 CYTIP MTIF2 BANK1 RASGRP2	2.39e-06	200	133	7	c07e37db9d50b91378d9c8355168745560cdbd25
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte\|LPS_only / Treatment groups by lineage, cell group, cell type	AFF2 SYNE1 GCGR KANK2 KANK1 FBN2 ATP1B2	2.39e-06	200	133	7	8c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 CYTIP NLRC5 FCRL5 BANK1 RASGRP2	2.39e-06	200	133	7	4f7be296be0cd54cfc62cc93263fde26210c61f4
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 DUSP9 BLM CLEC4E SGO2 FCRL5	9.34e-06	162	133	6	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	droplet-Spleen-nan-18m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 AFF2 SYNE1 CLEC4E LRP4 TMCC1	9.67e-06	163	133	6	bc37c5d9f48b16096d5313657563f3ec84028c8c
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 VWF OBSCN KANK1 OTOGL PROX1	1.11e-05	167	133	6	a4a795751644b22af616335379e64ae95175180c
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-mDC\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDKN1A IKZF1 WDFY4 TBC1D9 FCRL5 BANK1	1.15e-05	168	133	6	2dca1c4a33b6da9357fa3b2a523af19baab1c21c
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOE WDFY4 TBC1D9 FCRL5 C6 BANK1	1.23e-05	170	133	6	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	IKZF1 WDFY4 CYTIP TRPV3 FCRL5 BANK1	1.23e-05	170	133	6	a965e3ee6818790a4a6916824fde64333d9b11b7
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOE WDFY4 TBC1D9 FCRL5 C6 BANK1	1.23e-05	170	133	6	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYT1L DCHS2 FAT3 OTOGL ATP1B2 WDR17	1.23e-05	170	133	6	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPIRE2 VWF DLL1 KANK1 OTOGL PROX1	1.31e-05	172	133	6	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPIRE2 VWF DLL1 KANK1 OTOGL PROX1	1.31e-05	172	133	6	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IKZF1 CYTIP FCRL5 BANK1 CYTH4 RASGRP2	1.31e-05	172	133	6	0bcb960c5ab0d3cbbdf6235b6f28327ea60ba3e3
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CDKN1A TBC1D9 CLCN2 TRPV3 FCRL5 BANK1	1.40e-05	174	133	6	59ccc5a82507463e0a316ba6286cb25ec1a4091b
ToppCell	facs-Heart-LA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E IKZF1 WDFY4 CYTIP FCRL5 BANK1	1.50e-05	176	133	6	077f3fe5e3482ea3f639d789bd3d584161b36c02
ToppCell	Control-B_cells\|Control / group, cell type (main and fine annotations)	IKZF1 WDFY4 TBC1D9 CYTIP FCRL5 BANK1	1.50e-05	176	133	6	9125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCell	facs-Heart-LA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E IKZF1 WDFY4 CYTIP FCRL5 BANK1	1.50e-05	176	133	6	fc2ba468677b19b55130c1f06737f40300cd9d2e
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells-Memory_B\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF2 IKZF1 WDFY4 CYTIP FCRL5 BANK1	1.54e-05	177	133	6	0d1c39e99144fdb9c7f6f98a1ade41c73db45b65
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	WSCD1 VWF FAT3 KANK2 JAM3 PROX1	1.65e-05	179	133	6	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	Children_(3_yrs)-Immune-B_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	IKZF1 WDFY4 NLRC5 FCRL5 BANK1 RASGRP2	1.70e-05	180	133	6	40a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IKZF1 WDFY4 CYTIP NLRC5 BANK1 RASGRP2	1.75e-05	181	133	6	51e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	1.75e-05	181	133	6	51836cdc66e42f04ed6a3c167cd6a3a67428c9f7
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	1.75e-05	181	133	6	57f20341c3e9f9f6ed5b6c181605ad35bae91414
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E IKZF1 CYTIP GPSM1 BANK1 RASGRP2	1.75e-05	181	133	6	d90faa6115b408c9fbca61fc90ff951e070754ba
ToppCell	NS-critical-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SGCD ENPP2 ABCB5 APOE SYT14 JAM3	1.81e-05	182	133	6	dd1c59babf7211362452e3e264009d70004d99f6
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F FAT3 OBSCN FBN2 OTOGL TENM1	1.92e-05	184	133	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F FAT3 OBSCN FBN2 OTOGL TENM1	1.92e-05	184	133	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F FAT3 OBSCN FBN2 OTOGL TENM1	1.92e-05	184	133	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	COVID-19-lung-B_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	1.98e-05	185	133	6	e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCell	(1)_B_CD27neg\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	IKZF1 CYTIP FCRL5 BANK1 CYTH4 RASGRP2	2.04e-05	186	133	6	646389147189760e9493c4f50f9583959ef0ee26
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SOX6 SYNE1 KANK2 KANK1 ATP1B2 WDR17	2.04e-05	186	133	6	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	2.11e-05	187	133	6	8fa454dc4e6a3e8e2bb2ad803acc579e0d3f76da
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	2.11e-05	187	133	6	edad646d5eb1d70b768dc21fe02ef5265214e8e6
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CACNA1E SPIRE2 MYCBP2 ZDBF2 TBC1D9 GLG1	2.17e-05	188	133	6	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WSCD1 VWF ENPP2 MCC KANK3 JAM3	2.17e-05	188	133	6	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IKZF1 CYTIP NLRC5 FCRL5 BANK1 RASGRP2	2.17e-05	188	133	6	7447051dcdb949adc6af5814188674a489adf71f
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WDFY4 CYTIP NLRC5 FCRL5 BANK1 RASGRP2	2.24e-05	189	133	6	a12ca69eebc88725272c89d71a57fc6ce0c06813
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1L KIF26A GCGR SYT14 RIMBP2 FGL1	2.24e-05	189	133	6	cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DCHS2 SYNE1 OBSCN MCC KANK3 JAM3	2.30e-05	190	133	6	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	IKZF1 WDFY4 CYTIP NLRC5 FCRL5 BANK1	2.30e-05	190	133	6	424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATRX MYCBP2 CHD4 FBN1 GLG1 BANK1	2.30e-05	190	133	6	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	Fetal_29-31_weeks-Immune-B_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	IKZF1 WDFY4 CYTIP NLRC5 FCRL5 BANK1	2.37e-05	191	133	6	84452125d1b5b76974e3f9126f611eff16d45c25
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Radial_glial-RG\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	DLL1 EEF1D IFRD1 KANK3 PKM XPOT	2.44e-05	192	133	6	ee822325bb32ac7ad1eeccc23d966367e90a9edd
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1L KIF26A GCGR SYT14 RIMBP2 FGL1	2.52e-05	193	133	6	a189d46c39067b717509cd144e0225cc93d7731d
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1L KIF26A GCGR SYT14 RIMBP2 FGL1	2.52e-05	193	133	6	8851275bcf4ecd6e87a91c8784fc5d76d246ff3b
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 VWF KIF26A KANK3 ATP1B2 RASGRP2	2.52e-05	193	133	6	13731b7fc1e3bec0cebc44bad7e2ecea358bb76a
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 VWF KIF26A KANK3 ATP1B2 RASGRP2	2.52e-05	193	133	6	88cd7d0d0da5c776b49fc131f746fe5ad9676fb7
ToppCell	facs-MAT-Fat-3m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 VWF KIF26A DLL1 KANK3 PROX1	2.52e-05	193	133	6	e164f6403a8b541ced08a6feec915d2e855036ea
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	BDP1 ZDBF2 CHD4 WDFY4 TBC1D9 BANK1	2.52e-05	193	133	6	08696a99309f5b088692ddac8cca35413b5e810d
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 VWF KIF26A KANK3 ATP1B2 RASGRP2	2.52e-05	193	133	6	3a5090f81f35026f435f4a250d1e77601a53af15
ToppCell	facs-MAT-Fat-3m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 VWF KIF26A DLL1 KANK3 PROX1	2.52e-05	193	133	6	b32533afeff1905e188becaa09079e9699722e4b
ToppCell	facs-MAT-Fat-3m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSCD1 VWF KIF26A DLL1 KANK3 PROX1	2.52e-05	193	133	6	2ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DUSP9 GCGR TBC1D9 KANK1 ATP1B2 PROX1	2.52e-05	193	133	6	dd9874898587fe9fd9cf2aebc2e0579dcf06944e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DUSP9 GCGR TBC1D9 KANK1 ATP1B2 PROX1	2.59e-05	194	133	6	f08a7618a9ccf12e4a7620235ae662a8abc521af
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX6 AFF2 MCC TENM1 ATP1B2 PROX1	2.59e-05	194	133	6	02a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYT1L FAT3 FBN1 FBN2 OTOGL LRP4	2.67e-05	195	133	6	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	Mild/Remission-B_naive-8\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	BAZ2B IKZF1 MDM4 KANK2 ATAD2B RASGRP2	2.67e-05	195	133	6	0a3221e4d1fa31a35868bdda0f0cc873c233b407
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AFF2 ENPP2 LRP4 ATP1B2 JAM3 RASGRP2	2.67e-05	195	133	6	7a32a8535c29b819dacba901d0658280a2631c94
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX MYCBP2 CHD4 PKM PAX6 MGA	2.67e-05	195	133	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYT1L FAT3 FBN1 FBN2 OTOGL LRP4	2.67e-05	195	133	6	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AFF2 ENPP2 LRP4 ATP1B2 JAM3 RASGRP2	2.67e-05	195	133	6	4a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX MYCBP2 CHD4 PKM PAX6 MGA	2.67e-05	195	133	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 CYTIP TRPV3 FCRL5 BANK1	2.74e-05	196	133	6	fc67d8aad1ec4d7f98ffe44fb103e230b9b42c35
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX6 AFF2 MCC TENM1 ATP1B2 PROX1	2.74e-05	196	133	6	7af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PADI4 IKZF1 WDFY4 CYTIP FCRL5 BANK1	2.82e-05	197	133	6	fd65020089baca78334cecddc96b7a65028c2b7c
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	2.82e-05	197	133	6	ccabb976b5d4800e87e550640454a893fdb3b1b6
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	2.82e-05	197	133	6	0e56255862fed099e771ebd2529393dc5a3641ba
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 TBC1D9 FCRL5 BANK1 RASGRP2	2.82e-05	197	133	6	e4b4fa219322b3250b482f8e242f41e8b05485db
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IKZF1 WDFY4 CYTIP FCRL5 BANK1 RASGRP2	2.90e-05	198	133	6	4aa4ae2571effcfb6eb6923f7173cd3e7e4af9ef
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1L KIF26A GCGR SYT14 RIMBP2 FGL1	2.90e-05	198	133	6	50504a3871f76d6a5b439a56450d7770f4501eb0
ToppCell	Striatum-Neuronal\|Striatum / BrainAtlas - Mouse McCarroll V32	MYT1L GNL3L MYCBP2 NCDN TENM1 RIMBP2	3.07e-05	200	133	6	c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCell	Brain_organoid-organoid_Tanaka_cellReport\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	CDKN1A SGCD CHD4 APOE U2AF1 FBN1	3.07e-05	200	133	6	b0ba486b55be18a4236bd2644f02352651f4b1fe
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SOX6 MCC FBN2 TENM1 ATP1B2 PROX1	3.07e-05	200	133	6	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	WDFY4 TBC1D9 FCRL5 C6 BANK1	5.33e-05	135	133	5	7743a01dc9c4542e910e7c0fe046004692a680bf
ToppCell	Control-Myeloid-Dendritic_cells-pDC\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCB5 WDFY4 FCRL5 CYTH4 PROX1	7.49e-05	145	133	5	bab85a72142b6257f7d424e5301f65b6dcdf745d
ToppCell	Control-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WDFY4 TBC1D9 NLRC5 FCRL5 BANK1	8.25e-05	148	133	5	662c057030effc9eb61216e81d3967e6983c244f
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PCDHAC1 GCGR GPR101 ISM2	8.36e-05	77	133	4	afe990041849a68fd75e0c11b633a7b90fefade1
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PCDHAC1 GCGR GPR101 ISM2	8.36e-05	77	133	4	af7e1e76db33b115238b6fc61fc0dd86aab8e49d
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Nts\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PADI4 CYTIP CLEC4E ALPI	8.36e-05	77	133	4	dbbefd2dfa4c345172cb5a995952e3682fbadf92
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PCDHAC1 GCGR GPR101 ISM2	8.36e-05	77	133	4	ec8f625cae561986ed27dfaefa8f822dd1c4fba1
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF2 ENPP2 DLL1 LRP4 FCRL5	8.51e-05	149	133	5	aedbae2dffa1e880e5c6a146b6d5a135e7f54308
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCB5 IKZF1 TRPV3 FCRL5 NODAL	8.79e-05	150	133	5	17da17f01a3d41ac7df20f806e3eae30eca06982
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCB5 IKZF1 TRPV3 FCRL5 NODAL	8.79e-05	150	133	5	8702d5bb419d5e997d388e8f7e0365ba5d1de8d5
Disease	Autistic Disorder	MCC TSC1 CHD4 DLL1 TRRAP WDFY4 PAX6 ROBO3	2.41e-05	261	132	8	C0004352
Disease	Anorectal Malformations	SOX6 SGCD WDPCP TNNI3K	3.41e-05	41	132	4	C3495676
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	5.94e-05	3	132	2	DOID:65 (implicated_via_orthology)
Disease	smoking cessation	SOX6 CACNA1E KIF26A SGCD ENPP2 ATAD2B ATP1B2 NFAT5	1.12e-04	325	132	8	EFO_0004319
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	1.18e-04	4	132	2	DOID:0060249 (is_implicated_in)
Disease	dihydrofolate reductase measurement	VWF APOE	1.18e-04	4	132	2	EFO_0801526
Disease	congenital stationary night blindness (is_implicated_in)	CACNA1F TRPV3	1.18e-04	4	132	2	DOID:0050534 (is_implicated_in)
Disease	Insulinogenic index measurement	MYCBP2 GPSM1	1.97e-04	5	132	2	EFO_0009961
Disease	MYELODYSPLASTIC SYNDROME	ATRX BLM FANCD2 U2AF1	2.36e-04	67	132	4	C3463824
Disease	venous thromboembolism, fibrinogen measurement	DCHS2 VWF TRAFD1 LRP4	2.36e-04	67	132	4	EFO_0004286, EFO_0004623
Disease	stearoyl sphingomyelin (d18:1/18:0) measurement	APOE KANK3	2.94e-04	6	132	2	EFO_0800611
Disease	triglycerides to total lipids in small HDL percentage	APOE KANK3 NLRC5 BANK1	3.11e-04	72	132	4	EFO_0022336
Disease	Colorectal Carcinoma	SYNE1 ABCB5 OBSCN MCC NCDN LIG3 TNNI3K FBN2 TENM1 LZTS2 NODAL	3.28e-04	702	132	11	C0009402
Disease	Acute lymphocytic leukemia	IKZF1 BLM	4.11e-04	7	132	2	C0023449
Disease	pulse pressure measurement	SOX6 CDKN1A SGCD ENPP2 FAT3 PCDHAC1 APOE GPR101 TERF2 LIG3 FBN1 FBN2 PIK3C2A ATAD2B ROBO3 NFAT5	5.01e-04	1392	132	16	EFO_0005763
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	VWF FBN1	5.46e-04	8	132	2	DOID:4783 (biomarker_via_orthology)
Disease	risk-taking behaviour	MYT1L CACNA1E KIF26A DLL1 WDPCP TNNI3K GLG1 ATAD2B LRP4 NFAT5 BANK1	6.63e-04	764	132	11	EFO_0008579
Disease	cystic fibrosis (implicated_via_orthology)	ABCB5 CLCN2	7.00e-04	9	132	2	DOID:1485 (implicated_via_orthology)
Disease	triglycerides to total lipids in large VLDL percentage	APOE KANK2 NLRC5	7.11e-04	39	132	3	EFO_0022332
Disease	Odontome	LRP4 PAX6	8.73e-04	10	132	2	C0524730
Disease	Tooth Abnormalities	LRP4 PAX6	8.73e-04	10	132	2	C0040427
Disease	high grade glioma (is_implicated_in)	SOX6 CDKN1A ATRX	8.84e-04	42	132	3	DOID:3070 (is_implicated_in)
Disease	Abnormality of refraction	FAT3 PCDHAC1 APOE ZZEF1 IFRD1 FBN1 FBN2 SYT14 RIMBP2 C6	9.20e-04	673	132	10	HP_0000539
Disease	Intellectual Disability	MYT1L CACNA1E SYNE1 MCC OSGEP DLL1 TRRAP PAX6	9.35e-04	447	132	8	C3714756
Disease	Drugs used in diabetes use measurement	MYCBP2 DUSP9 ZZEF1 NFAT5 GPSM1 PROX1	1.04e-03	255	132	6	EFO_0009924
Disease	meningitis	CACNA1E SGCD	1.06e-03	11	132	2	MONDO_0021108
Disease	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	IKZF1 MGA	1.27e-03	12	132	2	C0023485
Disease	cancer (implicated_via_orthology)	DLL1 KANK2 KANK1 KANK3 GPSM1 PROX1	1.34e-03	268	132	6	DOID:162 (implicated_via_orthology)
Disease	plasma beta-amyloid 1-42 measurement	LRRC2 APOE	1.50e-03	13	132	2	EFO_0005660
Disease	middle temporal gyrus volume measurement, Alzheimer's disease biomarker measurement	MYCBP2 APOE	1.50e-03	13	132	2	EFO_0006514, EFO_0010316
Disease	Neoplasm of uncertain or unknown behavior of bladder	TSC1 MDM4	2.01e-03	15	132	2	C0496930
Disease	Benign neoplasm of bladder	TSC1 MDM4	2.01e-03	15	132	2	C0154017
Disease	Carcinoma in situ of bladder	TSC1 MDM4	2.01e-03	15	132	2	C0154091
Disease	Alobar Holoprosencephaly	DLL1 NODAL	2.01e-03	15	132	2	C0431363
Disease	triglycerides to total lipids in medium HDL percentage	APOE KANK3 NLRC5	2.04e-03	56	132	3	EFO_0022333
Disease	colorectal cancer (is_implicated_in)	MCC IKZF1 CHD4 TRPV3	2.17e-03	121	132	4	DOID:9256 (is_implicated_in)
Disease	birth weight	BAZ2B ENPP2 CRELD2 CYTIP ATAD2B GPSM1 PROX1	2.18e-03	399	132	7	EFO_0004344
Disease	Lobar Holoprosencephaly	DLL1 NODAL	2.29e-03	16	132	2	C0431362
Disease	Semilobar Holoprosencephaly	DLL1 NODAL	2.29e-03	16	132	2	C0751617
Disease	Diarrhea	WSCD1 GFM1	2.29e-03	16	132	2	HP_0002014
Disease	puberty onset measurement	SOX6 TNNI3K HERC2 NFAT5	2.44e-03	125	132	4	EFO_0005677
Disease	muscular dystrophy (is_implicated_in)	SGCD SYNE1	2.58e-03	17	132	2	DOID:9884 (is_implicated_in)
Disease	Disorder of eye	CYP4V2 CACNA1F WDPCP MFSD8 PAX6	2.70e-03	212	132	5	C0015397
Disease	Carcinoma of bladder	TSC1 MDM4	2.90e-03	18	132	2	C0699885
Disease	age at onset, Parkinson disease	APOE KLHDC1	2.90e-03	18	132	2	EFO_0004847, MONDO_0005180
Disease	Seizures	CACNA1E TSC1 APOE DLL1 TRRAP	3.04e-03	218	132	5	C0036572
Disease	depressive symptom measurement	SOX6 CACNA1E VWF WDPCP ATAD2B LRP4 PAX6	3.13e-03	426	132	7	EFO_0007006
Disease	diet measurement, HOMA-B	FAT3 NFAT5	3.23e-03	19	132	2	EFO_0004469, EFO_0008111
Disease	p-tau:beta-amyloid 1-42 ratio measurement	DDX49 APOE	3.23e-03	19	132	2	EFO_0007709
Disease	total lipids in very large HDL measurement	APOE NLRC5 BANK1	3.26e-03	66	132	3	EFO_0022312
Disease	phospholipids in very large HDL measurement	APOE NLRC5 BANK1	3.26e-03	66	132	3	EFO_0022298
Disease	skin pigmentation measurement	SPIRE2 FBN1 RIMBP2 HERC2	3.40e-03	137	132	4	EFO_0007009
Disease	triglycerides to phosphoglycerides ratio	APOE KANK3 BANK1	3.55e-03	68	132	3	EFO_0022327
Disease	cigarettes per day measurement	SOX6 SPIRE2 IKZF1 APOE NME9 WDPCP NFAT5	3.64e-03	438	132	7	EFO_0006525
Disease	cholesterol in very large HDL measurement	APOE NLRC5 BANK1	3.70e-03	69	132	3	EFO_0022229
Disease	Malignant Glioma	ATRX CLCN2 ATP1B2	3.85e-03	70	132	3	C0555198
Disease	mixed gliomas	ATRX CLCN2 ATP1B2	3.85e-03	70	132	3	C0259783
Disease	insomnia measurement	MYT1L MYCBP2 APOE TNNI3K PIK3C2A SYT14 BANK1	3.88e-03	443	132	7	EFO_0007876
Disease	emphysema imaging measurement	MYT1L MYCBP2 MCC RIMBP2	4.26e-03	146	132	4	EFO_0007626
Disease	blood pressure	SYNE1 BANK1	4.33e-03	22	132	2	EFO_0004325

Protein segments in the cluster

Peptide	Gene	Start	Entry
RMADSGESLCQNSIE	BANK1	291	Q8NDB2
ESCADRDTPQHMEDQ	BDP1	741	A6H8Y1
EREDEIATMECINNG	ALDH9A1	86	P49189
DSEQLSRDCDALMAG	CDKN1A	26	P38936
QAAQARLGADMEDVC	APOE	116	P02649
SSAQEMEQQLAEREC	COPS7B	226	Q9H9Q2
MCGAVNNLLSDTEED	CACNA1E	2296	Q15878
DSCDIGELNTRMTDD	ABCB5	156	Q2M3G0
CDSMEQFGQEESLDS	ACBD5	311	Q5T8D3
EEMFETSGDSLNCSN	BAZ2B	1426	Q9UIF8
DAALSFTECGNAMER	AFF2	1101	P51816
LACDGNEIDTMFVDR	ABHD16A	256	O95870
DASAIDFSRCDMDGA	ELF3	86	P78545
QIDCFESAEESRMAQ	CYTH4	46	Q9UIA0
DDETDMAQLEACVRS	EEF1D	206	P29692
MEDDNERPTGCSIEQ	MFSD8	391	Q8NHS3
LARASDSEEDMNNVC	RAD9B	396	Q6WBX8
SSNGEDSDEAQMRLQ	PAX6	191	P26367
LVNCDRDNLESSAMD	PADI4	151	Q9UM07
ADACRLTLDEMDNAA	CACNA1F	1926	O60840
DAFSGADMTQLCREA	FIGNL1	601	Q6PIW4
MSDQLCGIAACQTDD	KIAA0100	1556	Q14667
QQLRDSLDENEATMC	LZTS2	341	Q9BRK4
CREAMRLQAGEETAS	NCDN	701	Q9UBB6
MAVPEDLREACSNEN	FXR2	141	P51116
DLDQNQDGCISREEM	RASGRP2	466	Q7LDG7
DCGLSLDEDNMEFQV	MTIF2	691	P46199
SCQDQDDMAEKSGSE	MGA	1401	Q8IWI9
NLSEQRTDTENMEDC	MDM4	416	O15151
QSSRMDDQRCPLDDG	GPSM1	506	Q86YR5
IGPSCDNVEEDMNAS	HERC2	1821	O95714
DESSCDIMDLDQGQR	ATAD2B	1206	Q9ULI0
MNVTCAGKRDEDAEN	ATP1B2	196	P14415
RNATDMHDQDVDSCE	ISM2	391	Q6H9L7
SCEADNGLEAQRSEM	FCRL5	726	Q96RD9
SAMCQNLARTAEDDE	PIK3C2A	511	O00443
RDASQCQMDGEEIEV	GCGR	116	P47871
SEADRDSMSCGLDSE	DUSP9	176	Q99956
NIQDDEGSTALMCAS	KANK1	1261	Q14678
NAQCEDGNEIMESER	LRRC2	321	Q9BYS8
SDVANAVLDGADCIM	PKM	346	P14618
FAELQERLECMDGNE	KIF26A	841	Q9ULI4
DDSSSRIINGSDCDM	KLK5	61	Q9Y337
ASNDAGSARCEEQEM	JAM3	221	Q9BX67
VNQCSIDLGEDDMEF	GPR101	341	Q96P66
ENGRACEMNGEECAE	IKZF1	66	Q13422
CNPDDMARDLEQGDV	LIG3	336	P49916
ATDERFCIDNGAMIA	OSGEP	286	Q9NPF4
LLDNSRMSCQDEGCG	NFAT5	151	O94916
QLEDEGCRLMAEAAS	NLRC5	881	Q86WI3
NTDECFTINEMSGEL	DCHS2	1871	Q6V1P9
AEAGASAMLSCEVAQ	OBSCN	1086	Q5VST9
ADMPASARQEGCQDI	ALPI	191	P09923
DEDLDSNGRVICGMS	PCDHAC1	366	Q9H158
LMTNTCNAEDGELRE	WDPCP	711	O95876
DVADNQIDSGDLMEC	GLG1	706	Q92896
SDDISRDSDGMDEQC	ATRX	206	P46100
DMDNCSDLNSELQRV	MCC	151	P23508
CDTMADTLQRDGLAA	BLM	901	P54132
RQEEDCTFSIMENNG	C6	606	P13671
DPCRGETETMNNLAN	DLL1	581	O00548
DGKNCEDMDECSIRN	FBN1	566	P35555
MGREISALEDCAQEQ	FGL1	16	Q08830
DVSANCGFDDSEVAM	FAT3	4516	Q8TDW7
ERANEMNANEDCRGD	CYP4V2	271	Q6ZWL3
DEFVRENDCSSVQAM	CFAP100	201	Q494V2
GQMSELTDDCISVQD	CRYGB	101	P07316
MDCEVNNGSSLRDEC	BID	1	P55957
DAANCPSLENMDLDE	CYTIP	206	O60759
SCDDVNMRIAAGESL	IFRD1	276	O00458
DERPDERSDDMCSQG	MAP3K12	781	Q12852
DSEFRADGKNMRESC	HASPIN	256	Q8TF76
NVQDDDGSTALMCAC	KANK2	766	Q63ZY3
DVNAQDADGATALMC	KANK3	721	Q6NY19
MADSQLFCVAEERSG	KLHDC1	1	Q8N7A1
EAQCTELDMDDGRHS	PRPSAP1	201	Q14558
MDEADRLLEQGCTDF	DDX49	151	Q9Y6V7
SCLAELTMAEAEGNA	CUZD1	16	Q86UP6
NSGFALDMEERNCTD	FBN2	1101	P35556
EGCRDQDMDSDRAYQ	GPATCH2	186	Q9NW75
CSAGSEEEDMDALLN	CHD4	11	Q14839
GLCESSDFECNQMLE	CRELD2	81	Q6UXH1
CVANSDEQLGEMFLE	GFM1	256	Q96RP9
GMEDVTCDRTEFLSN	ENPP2	361	Q13822
SCERLQDEEASMGAS	FANCD2	116	Q9BXW9
SLNCSGEEASESLMN	PHKA2	931	P46019
CNEDPDDDLRMQNGT	OTOGL	1686	Q3ZCN5
CSTQAALQAMEREAE	NUMA1	961	Q14980
EMAANLTVQSESGCA	TAF5L	41	O75529
SGSARCRSESDMENE	RIMBP2	141	O15034
SEASIDEGNCIQRMR	SYT14	141	Q8NB59
LGMECDNNNDFDIAS	RNF157	611	Q96PX1
MAEFLDDQETRLCDN	TRAFD1	1	O14545
NDAGNFLIETCDEMV	SYNE1	661	Q8NF91
TEQASDSCLERFQMD	NODAL	121	Q96S42
EQANEDTMECLATGE	GNL3L	431	Q9NVN8
ARAQDSVGRSDNEMC	PROX1	286	Q92786
SAREPNAECMNQIED	SGO2	336	Q562F6
VCCDMEAQAGSTQDV	TENM1	166	Q9UKZ4
QNSMVEFCESDEGEA	MYCBP2	2641	O75592
CQEELGAEEEMAARA	VHLL	26	Q6RSH7
ECMQLAETARADDNI	WDR17	1081	Q8IZU2
QREGSCMAEDDAVDI	RNF220	331	Q5VTB9
SNVARCSSMDNGLED	STARD9	3506	Q9P2P6
ACAADGEDAMTQDLT	SOX6	11	P35712
NNIATLEDCATMRDS	CLEC4E	171	Q9ULY5
ELQEDARIRGMSNCS	C12orf54	56	Q6X4T0
ENESRNTEMLAAACA	CLCN2	231	P51788
FRNKSESQCDEDGMT	TSC1	1096	Q92574
REDSDMAQDSLQCLA	XPO4	286	Q9C0E2
GICDENGANDFMLRD	VWF	2086	P04275
CFSRDTEMLATGAQD	SMU1	271	Q2TAY7
AEAGNMEATCRTELR	SGCD	211	Q92629
LMANNDSEDSGCGAA	SPIRE2	131	Q8WWL2
CVASNMAGERESAAA	ROBO3	236	Q96MS0
RDNGACSSMLISDDD	TBC1D9	1141	Q6ZT07
SSVNERQICMDGALD	WDFY4	1561	Q6ZS81
CGSEMNFNVDASDQS	ZDBF2	1621	Q9HCK1
MDLESQNACAEIDGV	TMCC1	81	O94876
SESQNRESCDMSLGA	USF3	1871	Q68DE3
CSAAAVRTGDMESQR	TBCC	6	Q15814
NNGEDEDMVSSERTC	NME9	146	Q86XW9
SADGLRCAVSDVEMQ	U2AF1	61	Q01081
MLAQDEERQASLADC	XPOT	636	O43592
DSQCNTEEGCDELAM	ZZEF1	2731	O43149
EMSDRLENCDLEESN	ZNF420	71	Q8TAQ5
NIRQCISGNCDDMDS	TRPV3	71	Q8NET8
LRDAMDSSVCGQDPE	WSCD1	306	Q658N2
DNGADMNLVACDPSR	TNNI3K	361	Q59H18
STNSELQEAGEACMR	TRRAP	1396	Q9Y4A5
RIEEGENLDCSFDME	TERF2	151	Q15554
QGQDCVADMVTADDS	WDR54	176	Q9H977
NDCSMDAAERNAEGG	PP6455	116	Q8WZ26
GDNSDEQCDMRKCSD	LRP4	136	O75096
DLCATRNPDMEVDEN	MYT1L	756	Q9UL68