Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SP3 SP4 POU6F2 ZNF354A PKNOX1 POU2F1 CHD7 ZNF236 ZNF853 NFAT5 AR ZBTB24	2.21e-05	1244	47	12	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SP3 SP4 POU6F2 ZNF354A PKNOX1 POU2F1 CHD7 ZNF236 ZNF853 NFAT5 AR ZBTB24	2.73e-05	1271	47	12	GO:0000987
GeneOntologyMolecularFunction	chromatin binding	TPR SP3 IFT74 PKNOX1 POU2F1 CHD7 NFAT5 AR TOP2A	4.78e-05	739	47	9	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SP3 SP4 POU6F2 ZNF354A PKNOX1 POU2F1 CHD7 ZNF236 ZNF853 NFAT5 AR ZBTB24	1.05e-04	1459	47	12	GO:0000977
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD9 CHD7 TOP2A HELB	2.25e-04	127	47	4	GO:0008094
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SP3 SP4 POU6F2 ZNF354A PKNOX1 POU2F1 ZNF236 ZNF853 NFAT5 AR ZBTB24	3.46e-04	1412	47	11	GO:0000981
Domain	LRR_8	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	4.81e-06	171	48	6	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	5.87e-06	177	48	6	IPR003591
Domain	LRR_TYP	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	5.87e-06	177	48	6	SM00369
Domain	LRR	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	1.21e-05	201	48	6	PS51450
Domain	Ago_hook	TNRC6A TNRC6B	1.94e-05	3	48	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6A TNRC6B	1.94e-05	3	48	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6A TNRC6B	1.94e-05	3	48	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6A TNRC6B	1.94e-05	3	48	2	PF16608
Domain	LRR_1	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	1.97e-05	219	48	6	PF00560
Domain	LRRC37AB_C	LRRC37A LRRC37A2	3.87e-05	4	48	2	PF14914
Domain	LRRC37_N	LRRC37A LRRC37A2	3.87e-05	4	48	2	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A2	3.87e-05	4	48	2	IPR029423
Domain	LRRC37	LRRC37A LRRC37A2	3.87e-05	4	48	2	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A2	3.87e-05	4	48	2	IPR015753
Domain	Leu-rich_rpt	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	6.50e-05	271	48	6	IPR001611
Domain	BRK	CHD9 CHD7	9.64e-05	6	48	2	SM00592
Domain	BRK_domain	CHD9 CHD7	9.64e-05	6	48	2	IPR006576
Domain	BRK	CHD9 CHD7	9.64e-05	6	48	2	PF07533
Domain	-	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	1.64e-04	321	48	6	3.80.10.10
Domain	L_dom-like	LRRC37A LRRTM2 LRRC37A2 TLR7 LRRC30 LRRD1	1.85e-04	328	48	6	IPR032675
Domain	Sp1_fam	SP3 SP4	2.87e-04	10	48	2	IPR030450
Domain	UBA-like	UBQLN2 TNRC6A TNRC6B	5.95e-04	64	48	3	IPR009060
Domain	POU	POU6F2 POU2F1	7.58e-04	16	48	2	SM00352
Domain	POU_2	POU6F2 POU2F1	7.58e-04	16	48	2	PS00465
Domain	POU_dom	POU6F2 POU2F1	7.58e-04	16	48	2	IPR000327
Domain	POU_3	POU6F2 POU2F1	7.58e-04	16	48	2	PS51179
Domain	Pou	POU6F2 POU2F1	7.58e-04	16	48	2	PF00157
Domain	POU_1	POU6F2 POU2F1	7.58e-04	16	48	2	PS00035
Domain	POU	POU6F2 POU2F1	8.58e-04	17	48	2	IPR013847
Domain	Chromo_domain	CHD9 CHD7	1.72e-03	24	48	2	IPR023780
Domain	Chromo	CHD9 CHD7	2.02e-03	26	48	2	PF00385
Domain	-	POU6F2 POU2F1	2.18e-03	27	48	2	1.10.260.40
Domain	CHROMO_1	CHD9 CHD7	2.34e-03	28	48	2	PS00598
Domain	CHROMO_2	CHD9 CHD7	2.34e-03	28	48	2	PS50013
Domain	Lambda_DNA-bd_dom	POU6F2 POU2F1	2.51e-03	29	48	2	IPR010982
Domain	SNF2_N	CHD9 CHD7	3.05e-03	32	48	2	IPR000330
Domain	Chromodomain-like	CHD9 CHD7	3.05e-03	32	48	2	IPR016197
Domain	SNF2_N	CHD9 CHD7	3.05e-03	32	48	2	PF00176
Domain	Chromo/shadow_dom	CHD9 CHD7	3.25e-03	33	48	2	IPR000953
Domain	CHROMO	CHD9 CHD7	3.25e-03	33	48	2	SM00298
Domain	-	POU6F2 SSH1 PKNOX1 POU2F1	5.95e-03	283	48	4	1.10.10.60
Domain	-	SP3 SP4 ZNF354A ZNF236 ZNF853 ZBTB24	7.56e-03	679	48	6	3.30.160.60
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B	9.45e-05	6	36	2	MM15083
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	CDKN2C TNRC6A TNRC6B	9.46e-05	35	36	3	M27190
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B	1.32e-04	7	36	2	M46421
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	TNRC6A TNRC6B	2.26e-04	9	36	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	TNRC6A TNRC6B	2.26e-04	9	36	2	M46436
Pathway	REACTOME_GENE_SILENCING_BY_RNA	TPR TNRC6A TNRC6B	2.60e-04	49	36	3	MM14837
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	TNRC6A TNRC6B	2.82e-04	10	36	2	M48013
Pathway	KEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY	DUOX2 TG	4.12e-04	12	36	2	M47628
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	TNRC6A TNRC6B	4.86e-04	13	36	2	M46434
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	TNRC6A TNRC6B	8.42e-04	17	36	2	M27788
Pathway	REACTOME_SUMOYLATION	TPR SP3 AR TOP2A	8.71e-04	169	36	4	MM14919
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	TNRC6A TNRC6B	1.06e-03	19	36	2	M48238
Pathway	REACTOME_SUMOYLATION	TPR SP3 AR TOP2A	1.32e-03	189	36	4	M27214
Pubmed	Role of GW182 protein in the cell.	TNRC6A TNRC6B	2.11e-06	2	51	2	29791863
Pubmed	GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation.	GRB10 GIGYF2	2.11e-06	2	51	2	20670374
Pubmed	Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression.	AR TOP2A	2.11e-06	2	51	2	26560244
Pubmed	Integrative Genomic Analysis of OCT1 Reveals Coordinated Regulation of Androgen Receptor in Advanced Prostate Cancer.	POU2F1 AR	2.11e-06	2	51	2	30649323
Pubmed	Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions.	POU2F1 AR	2.11e-06	2	51	2	19058140
Pubmed	Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.	SP3 SP4	2.11e-06	2	51	2	1454515
Pubmed	GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells.	GRB10 AR	2.11e-06	2	51	2	33038264
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TPR KIF15 IFT74 TNRC6A TNRC6B GIGYF2 CHD7	2.53e-06	418	51	7	34709266
Pubmed	Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.	PKNOX1 ZBTB24 TOP2A	4.49e-06	22	51	3	31839203
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	TNRC6A TNRC6B GIGYF2 TOP2A	5.97e-06	80	51	4	35803934
Pubmed	A census of human transcription factors: function, expression and evolution.	SP3 SP4 POU6F2 PKNOX1 POU2F1 ZNF236 NFAT5 AR ZBTB24	6.16e-06	908	51	9	19274049
Pubmed	Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.	SP3 SP4	6.32e-06	3	51	2	23540600
Pubmed	Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.	SP3 SP4	6.32e-06	3	51	2	26967243
Pubmed	Curcumin decreases specificity protein expression in bladder cancer cells.	SP3 SP4	6.32e-06	3	51	2	18593936
Pubmed	Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.	SP3 SP4	6.32e-06	3	51	2	15265862
Pubmed	KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.	KIF15 AR	6.32e-06	3	51	2	33277366
Pubmed	Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.	SP3 SP4	6.32e-06	3	51	2	11532028
Pubmed	Genotypes and phenotypes of congenital goitre and hypothyroidism caused by mutations in dual oxidase 2 genes.	DUOX2 TG	6.32e-06	3	51	2	24735383
Pubmed	Expression of the muscle atrophy factor muscle atrophy F-box is suppressed by testosterone.	POU2F1 AR	6.32e-06	3	51	2	18599544
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6A TNRC6B	6.32e-06	3	51	2	34108231
Pubmed	Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment.	GRB10 GIGYF2	6.32e-06	3	51	2	25268761
Pubmed	Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.	SP3 SP4	6.32e-06	3	51	2	21919647
Pubmed	O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.	SP3 SP4	6.32e-06	3	51	2	26431879
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6A TNRC6B	6.32e-06	3	51	2	16880270
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6A TNRC6B	6.32e-06	3	51	2	31670606
Pubmed	Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.	SP3 SP4	6.32e-06	3	51	2	7559627
Pubmed	Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.	SP3 SP4	1.26e-05	4	51	2	15781457
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A2	1.26e-05	4	51	2	22419166
Pubmed	Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct.	POU2F1 AR	1.26e-05	4	51	2	11997177
Pubmed	Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.	SP3 SP4	1.26e-05	4	51	2	27889927
Pubmed	Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.	SP3 SP4	1.26e-05	4	51	2	16574784
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6A TNRC6B	1.26e-05	4	51	2	21063388
Pubmed	TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.	PKNOX1 POU2F1	1.26e-05	4	51	2	15138251
Pubmed	Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1.	POU2F1 AR	1.26e-05	4	51	2	11096094
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TNRC6A TNRC6B MACF1 WWC1 HELB	1.40e-05	209	51	5	36779422
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TNRC6B GIGYF2 MACF1 CHD7 ZBTB24	2.00e-05	225	51	5	12168954
Pubmed	Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.	SP3 SP4	2.10e-05	5	51	2	20538607
Pubmed	Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.	SP3 SP4	2.10e-05	5	51	2	10547281
Pubmed	The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling.	GRB10 GIGYF2	2.10e-05	5	51	2	16037382
Pubmed	Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.	POU2F1 AR	2.10e-05	5	51	2	25802280
Pubmed	Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.	SP3 SP4	2.10e-05	5	51	2	12560508
Pubmed	Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.	GRB10 GIGYF2	2.10e-05	5	51	2	12771153
Pubmed	Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.	SP3 POU2F1	2.10e-05	5	51	2	16061936
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	TPR COLEC12 HLA-DPA1 MACF1 POU2F1 CASR TLR7 NFAT5	2.48e-05	824	51	8	20237496
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRRTM2 GRB10 TNRC6B GIGYF2 MACF1 NFAT5	2.86e-05	407	51	6	12693553
Pubmed	Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.	GRB10 GIGYF2	3.15e-05	6	51	2	20878056
Pubmed	Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.	DUOX2 TG	3.15e-05	6	51	2	17332529
Pubmed	The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3.	SP3 CASR	3.15e-05	6	51	2	18348986
Pubmed	Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.	SP3 SP4	3.15e-05	6	51	2	7800480
Pubmed	Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.	SP3 SP4	3.15e-05	6	51	2	16201967
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	POU6F2 ZNF354A PKNOX1 POU2F1 MYOCD ZNF236 AR ZBTB24	3.86e-05	877	51	8	20211142
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6A TNRC6B	4.41e-05	7	51	2	19470757
Pubmed	POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.	SP3 SP4	4.41e-05	7	51	2	12004059
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6A TNRC6B	4.41e-05	7	51	2	19383768
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TPR KIF15 SSH1 TNRC6B GIGYF2 MACF1 GOLGA6B CHD7	7.44e-05	963	51	8	28671696
Pubmed	Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter.	POU2F1 AR	7.54e-05	9	51	2	10480874
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A2	9.42e-05	10	51	2	23064749
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	IFT74 TNRC6A TNRC6B GIGYF2	1.13e-04	169	51	4	31462741
Pubmed	Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase.	ZNF354A AR	1.15e-04	11	51	2	12943985
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TPR RBM27 IFT74 TNRC6B GIGYF2 TOP2A	1.48e-04	549	51	6	38280479
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	RBM27 TNRC6A TNRC6B GIGYF2	1.56e-04	184	51	4	32908313
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SP3 SP4 PKNOX1 POU2F1 ZNF236 NFAT5 ZBTB24	1.69e-04	808	51	7	20412781
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	TNRC6A TNRC6B	1.90e-04	14	51	2	19716330
Pubmed	Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.	POU2F1 TOP2A	2.19e-04	15	51	2	12393188
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6A TNRC6B	2.19e-04	15	51	2	21981923
Pubmed	Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.	CDKN2C CASR	2.50e-04	16	51	2	30979723
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FSIP2 POU2F1 CHD9 CHD7 ZBTB24 TOP2A	2.57e-04	608	51	6	36089195
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	POU6F2 GRB10 TNRC6B MACF1 CHD9 NCAM2 ZNF236 NFAT5 AR	2.82e-04	1489	51	9	28611215
Pubmed	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	HLA-DPA1 GRB10	2.83e-04	17	51	2	21779181
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	TNRC6B GIGYF2	3.18e-04	18	51	2	25363768
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	TPR GIGYF2 MACF1 TOP2A	3.89e-04	234	51	4	36243803
Pubmed	Evolutionary breakpoints on human chromosome 21.	PKNOX1 NCAM2	3.94e-04	20	51	2	11707078
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NFAT5 DENND3 WWC1	4.35e-04	100	51	3	10048485
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	UBQLN2 TNRC6A TNRC6B GIGYF2	4.42e-04	242	51	4	34011540
Pubmed	Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.	TNRC6A TNRC6B	4.78e-04	22	51	2	22187428
Pubmed	Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.	TNRC6B GIGYF2	5.23e-04	23	51	2	20696395
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TNRC6A TNRC6B	5.23e-04	23	51	2	28811219
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	TNRC6A GIGYF2	5.23e-04	23	51	2	9225980
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	TNRC6A TNRC6B GIGYF2	5.30e-04	107	51	3	30995489
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	TPR KIF15 RBM27 GIGYF2	5.46e-04	256	51	4	33397691
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	TNRC6A TNRC6B GIGYF2 MACF1	6.04e-04	263	51	4	34702444
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SSH1 TNRC6A CHD7 TOP2A HELB	6.15e-04	469	51	5	27634302
Pubmed	DNA segments mapped by reciprocal use of microsatellite primers between mouse and rat.	AR TG	6.19e-04	25	51	2	8268655
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	IFT74 DRC1	6.19e-04	25	51	2	27340223
Pubmed	Mammalian SP/KLF transcription factors: bring in the family.	SP3 SP4	6.19e-04	25	51	2	15820306
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	DUOX2 TG	6.70e-04	26	51	2	33905568
Pubmed	Global gene expression analysis of murine limb development.	SP4 PKNOX1 NFAT5	6.87e-04	117	51	3	22174793
Pubmed	DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.	TPR ZBTB24 TOP2A	7.04e-04	118	51	3	37105989
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	TPR RBM27 CHD7 TOP2A	7.94e-04	283	51	4	30585729
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	FSIP2 IFT74 TNRC6B	7.94e-04	123	51	3	26912792
Pubmed	Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.	SSH1 GOLGA6B	8.35e-04	29	51	2	30228103
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR SSH1 GIGYF2 POU2F1 CHD7 TOP2A	9.15e-04	774	51	6	15302935
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	GRB10 MACF1 NFAT5	9.32e-04	130	51	3	12421765
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TNRC6A PKNOX1 TNRC6B CHD7 WWC1	1.12e-03	536	51	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TNRC6A PKNOX1 TNRC6B CHD7 WWC1	1.14e-03	538	51	5	10512203
Pubmed	Goofy coordinates the acuity of olfactory signaling.	NCAM2 GOLGA6B	1.15e-03	34	51	2	23926254
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TNRC6A TNRC6B MACF1 CHD9 TRAF3IP3 TOP2A WWC1	1.16e-03	1116	51	7	31753913
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	CDKN2C TNRC6A DUOX2 CHD7 DENND3	1.27e-03	552	51	5	10737800
Pubmed	Heart neurons use clock genes to control myocyte proliferation.	CDKN2C TOP2A	1.36e-03	37	51	2	34851661
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	SP3 AR	1.43e-03	38	51	2	27930960
Interaction	PHF21A interactions	TPR SP3 KIF15 IFT74 TNRC6A TNRC6B GIGYF2 CHD7 AR	1.22e-07	343	49	9	int:PHF21A
Interaction	GSK3A interactions	LRRC37A2 TNRC6A TNRC6B MACF1 DRC1 AR WWC1 HELB	1.46e-05	464	49	8	int:GSK3A
Interaction	FHL2 interactions	SP3 SP4 POU6F2 RBM27 PKNOX1 NFAT5 AR	4.52e-05	396	49	7	int:FHL2
Interaction	MN1 interactions	PKNOX1 ZBTB24 TOP2A	4.72e-05	29	49	3	int:MN1
Interaction	POU2F1 interactions	SP4 POU6F2 PKNOX1 POU2F1 AR	6.53e-05	175	49	5	int:POU2F1
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6A TNRC6B GIGYF2	1.62e-05	25	36	3	775
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP3 SP4	1.38e-04	9	36	2	755
GeneFamily	POU class homeoboxes and pseudogenes	POU6F2 POU2F1	9.50e-04	23	36	2	523
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP3 SP4 ZNF354A ZNF236 ZNF853 ZBTB24	2.70e-03	718	36	6	28
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	SSH1 RBM27 TNRC6A TNRC6B GIGYF2 CHD9 MYOCD WWC1	3.11e-06	467	51	8	M1347
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	SSH1 RBM27 TNRC6A TNRC6B GIGYF2 CHD9 MYOCD WWC1	4.05e-06	484	51	8	MM999
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	TPR SP4 FAM184A UBQLN2 ZNF354A KIF15 RBM27 IFT74 MACF1 POU2F1 CHD9 TLR7 CHD7 TOP2A	4.40e-06	1459	50	14	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	TPR SP4 FAM184A UBQLN2 ZNF354A KIF15 RBM27 IFT74 MACF1 POU2F1 CHD9 TLR7 TOP2A	4.67e-06	1257	50	13	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_500_k-means-cluster#1	SP4 POU2F1 CHD7 WWC1	2.49e-05	72	50	4	Facebase_RNAseq_e9.5_Olfactory Placode_500_K1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_500_k-means-cluster#4	SP4 MACF1 CHD7 WWC1	8.35e-05	98	50	4	Facebase_RNAseq_e10.5_Olfactory Pit_500_K4
CoexpressionAtlas	alpha beta T cells, T.4Nve.PP, TCR+ CD4+ CD44low CD62Lhigh, Peyer's Patch, avg-2	TPR SP4 BICDL1 MACF1 CHD7 TRAF3IP3	1.14e-04	327	50	6	GSM538380_500
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	BICDL1 LRRC37A TNRC6B MACF1 HELB	1.17e-06	162	51	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	COVID-19_Convalescent-PLT_4\|World / Disease Group and Platelet Clusters	SP4 GIGYF2 POU2F1 CHD9 ZNF236	2.30e-06	186	51	5	5954a1e3ffafb33f2a9bc87af3343f304fda4c92
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BICDL1 TNRC6B TRAF3IP3 HELB TG	2.49e-06	189	51	5	df30478b288084a1bd48f660409dcc784040897c
ToppCell	moderate-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BICDL1 TNRC6B MACF1 TRAF3IP3 CCDC107	2.98e-06	196	51	5	9152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	BICDL1 TNRC6B MACF1 TOP2A	1.74e-05	135	51	4	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	BICDL1 TNRC6B MACF1 HELB	2.69e-05	151	51	4	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	BICDL1 FAM184A MACF1 HELB	3.06e-05	156	51	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	15-Airway-Immune-Hematopoietic,_B_Cells\|Airway / Age, Tissue, Lineage and Cell class	KIF15 HLA-DPA1 TLR7 TRAF3IP3	4.48e-05	172	51	4	36f2444754f1e37683cb812380e6b05b356f9f4a
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MACF1 CHD9 MYOCD	4.90e-05	176	51	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	BICDL1 FAM184A CASR WWC1	4.90e-05	176	51	4	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MACF1 CHD9 DRC1	5.58e-05	182	51	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MACF1 CHD9 DRC1	5.58e-05	182	51	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BICDL1 FAM184A TNRC6A HELB	5.82e-05	184	51	4	5350b58aa9979631228835d11eb45ddf81d08bff
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TPR SP3 GIGYF2 NFAT5	6.07e-05	186	51	4	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BICDL1 TRAF3IP3 PZP HELB	6.59e-05	190	51	4	2a8de1cf27a9ebc3825cf9e7a489ecd064dfc7f9
ToppCell	3'_v3-blood-Lymphocytic_T_CD8-Tem/emra_CD8\|blood / Manually curated celltypes from each tissue	HLA-DPA1 MACF1 TRAF3IP3 PZP	6.59e-05	190	51	4	5624f711b34132081f93fa70702316962e3e3c64
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 HLA-DPA1 TLR7 TOP2A	6.73e-05	191	51	4	ff2cc4c10aa584b3daeaaf23cd8ee09bdbdf684d
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BICDL1 TRAF3IP3 PZP HELB	6.73e-05	191	51	4	c7be771543089fc94e5c62fd22f745189642aec3
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BICDL1 TRAF3IP3 PZP HELB	6.87e-05	192	51	4	69a2b04f03a1b82d067018379f7b8a116e954040
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	BICDL1 FAM184A MACF1 HELB	6.87e-05	192	51	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	TNRC6A GRB10 TNRC6B MACF1	6.87e-05	192	51	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	COVID-19-lung-CD8+_T_cells\|lung / Disease (COVID-19 only), tissue and cell type	BICDL1 TRAF3IP3 PZP HELB	7.01e-05	193	51	4	780e23e2705fc5c1b70e37568b79731ced5038bd
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BICDL1 TRAF3IP3 PZP HELB	7.01e-05	193	51	4	b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR KIF15 CHD9 TOP2A	7.15e-05	194	51	4	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	Immune-T_lymphocyte\|World / Lineage, Cell type, age group and donor	BICDL1 TRAF3IP3 PZP HELB	7.15e-05	194	51	4	f47fa18c87b35a3960557f8169ff7830dd6ecb80
ToppCell	mild-dn_T\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CDKN2C FAM184A TOP2A WWC1	7.29e-05	195	51	4	158f0f229bad71cc9b06b7399168982bbbbd1d47
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	KIF15 DRC1 TOP2A WWC1	7.58e-05	197	51	4	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	mild-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CDKN2C FAM184A TOP2A HELB	7.58e-05	197	51	4	07a1f59c83b748825e0708cd1cc7b63a2cb856cc
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	KIF15 DRC1 TOP2A WWC1	7.58e-05	197	51	4	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKN2C COLEC12 KIF15 TOP2A	7.58e-05	197	51	4	29b0a5927f80455eef7b793feabef69fba1a3df1
ToppCell	18-Airway-Mesenchymal-Mesenchyme_RSPO2+\|Airway / Age, Tissue, Lineage and Cell class	CDKN2C KIF15 MACF1 TOP2A	7.89e-05	199	51	4	7ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CDKN2C KIF15 CHD7 TOP2A	7.89e-05	199	51	4	53b3d35767889a152f1f38e8f6f0ba8f7a7690f2
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FSIP2 BICDL1 DENND3	2.11e-04	101	51	3	657d3994b93e2fbb1ff96f701ff2ea6665e5a15c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DPA1 GRB10 TLR7	2.72e-04	110	51	3	0b39f3c358715e6e7288d3e4a0f3e7c0e877333c
ToppCell	(05)_Ciliated-(3)_72hpi\|(05)_Ciliated / shred by cell type and Timepoint	GRB10 TOP2A DENND3	2.94e-04	113	51	3	eaa5bc8f8183b353ee1e7618e99220eb3684cd60
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	TNRC6B MACF1 PZP	3.60e-04	121	51	3	19333a660800b583fa27b495c1f7828e6636a257
ToppCell	356C-Myeloid-Dendritic-cDC2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	HLA-DPA1 DENND3 CCDC107	4.05e-04	126	51	3	197d2c836ae46a5c67f68d10c71ba86b7b40b59d
ToppCell	LPS-IL1RA-Lymphocytic_NKT-T_cells-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BICDL1 FAM184A TRAF3IP3	4.24e-04	128	51	3	c2045f052cc713e52312eb015825711576fcb6c5
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU6F2 MYOCD TG	4.54e-04	131	51	3	81efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9\|TCGA-Bladder / Sample_Type by Project: Shred V9	TPR CHD9 GOLGA6B	4.64e-04	132	51	3	48449e2e95804a26f204ac7ea763dee26cf794ab
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SP4 TRAF3IP3 AR	5.62e-04	141	51	3	d3ce2218bfa9750795d920e1ef162ea44efb2e66
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKN2C KIF15 TOP2A	5.74e-04	142	51	3	be63c48794a227ea55978524c0f5935342fc455e
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOCD TLR7 PZP	6.47e-04	148	51	3	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	P03-Hematopoietic-Immune-immune_cell_unspecified\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TLR7 TRAF3IP3 TG	6.60e-04	149	51	3	43d756f81d532b5c7f2306e6af9d072d496cbc8e
ToppCell	E16.5-samps\|World / Age Group, Lineage, Cell class and subclass	KIF15 GRB10 TOP2A	6.60e-04	149	51	3	e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCell	P03-Hematopoietic-Immune\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TLR7 TRAF3IP3 TG	6.60e-04	149	51	3	1c5a2572741c47246d455c865e8e1677c9f49598
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	BICDL1 LRRTM2 TG	7.26e-04	154	51	3	a90c4c45685eae8d21d03479cfd5a23f6ed3ca07
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CDKN2C MYOCD LRRD1	7.40e-04	155	51	3	cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCell	368C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FSIP2 TLR7 TOP2A	7.54e-04	156	51	3	4877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	BICDL1 FAM184A AR	7.54e-04	156	51	3	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	BICDL1 FAM184A AR	7.54e-04	156	51	3	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	368C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FSIP2 TLR7 TOP2A	7.54e-04	156	51	3	1d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRTM2 GIGYF2 TLR7	7.82e-04	158	51	3	b0508a600994090c6aafd8d779437190a33ad821
ToppCell	facs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRTM2 GIGYF2 TLR7	7.82e-04	158	51	3	a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCell	390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|390C / Donor, Lineage, Cell class and subclass (all cells)	KIF15 LRRTM2 TOP2A	7.96e-04	159	51	3	0fbfdb18b7ed4bde077add13f2b3636e144b254f
ToppCell	normal_Pleural_Fluid-B_lymphocytes-Undetermined\|normal_Pleural_Fluid / Location, Cell class and cell subclass	HLA-DPA1 TNRC6B CHD7	8.11e-04	160	51	3	5744cd30709f38e84f7ec8893dc19d7a288b465a
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|Lung / Manually curated celltypes from each tissue	FSIP2 IFT74 HELB	8.11e-04	160	51	3	9f7f24a52a24fb926df69c8e5aad64ee75a66ef1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BICDL1 FAM184A CASR	8.11e-04	160	51	3	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 FAM184A CASR	8.41e-04	162	51	3	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDKN2C KIF15 TOP2A	8.56e-04	163	51	3	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIF15 LRRTM2 TOP2A	8.56e-04	163	51	3	aa5ea367f787c1543afb7eb80a801432e1c44011
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|356C / Donor, Lineage, Cell class and subclass (all cells)	SP3 LRRC37A LRRC37A2	8.71e-04	164	51	3	d5bb57c321f2973836efc8990449494cc1fb87c7
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF354A KIF15 TOP2A	8.71e-04	164	51	3	5621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CDKN2C KIF15 TOP2A	8.86e-04	165	51	3	eec2d327c94832d1390314c93ef6a2be4648478b
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKN2C KIF15 TOP2A	8.86e-04	165	51	3	26c750f10f6401752e2e63d91dc844c81b29d735
ToppCell	Dividing_Macrophages-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	CDKN2C KIF15 TOP2A	9.02e-04	166	51	3	ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	KIF15 TOP2A TG	9.18e-04	167	51	3	315cde87eed2b42a1b9b068fae94caa10ec64c70
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CDKN2C KIF15 TOP2A	9.18e-04	167	51	3	9280558baddea51aae47f3383d895a9b0c6749a4
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CDKN2C KIF15 TOP2A	9.18e-04	167	51	3	3461d14e36f09ddc6ee5549ca4797e16d3f37fcc
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF15 DRC1 TOP2A	9.18e-04	167	51	3	754e6412d3b9cc0b126e59593df2f5956b4712ef
ToppCell	COVID-19_Moderate-Treg\|COVID-19_Moderate / disease group, cell group and cell class	BICDL1 POU6F2 TRAF3IP3	9.18e-04	167	51	3	4ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	TLR7 TRAF3IP3 PZP	9.18e-04	167	51	3	d2230c894ccf9dbba9196e079ae81f384d43da63
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TOP2A WWC1 TG	9.18e-04	167	51	3	a90f905ef38437752e2b0b71bd0322a184de1861
ToppCell	normal_Lung-T/NK_cells-Exhausted_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	BICDL1 HLA-DPA1 NCAM2	9.34e-04	168	51	3	76b49463895cdef27c90f831c6246bcb92b9761b
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	KIF15 PKNOX1 GRB10	9.34e-04	168	51	3	53a982869dbf14f6a948589be9f2f3df3b9a7e97
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKN2C KIF15 TOP2A	9.34e-04	168	51	3	52fd65024af8683db11d931f7563cbe8eb815d1c
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COLEC12 MACF1 NCAM2	9.50e-04	169	51	3	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	COVID-19_Mild-PLT_2\|World / Disease Group and Platelet Clusters	BICDL1 TLR7 CHD7	9.50e-04	169	51	3	6abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COLEC12 KIF15 TOP2A	9.50e-04	169	51	3	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDKN2C KIF15 TOP2A	9.50e-04	169	51	3	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	BICDL1 HLA-DPA1 PZP	9.50e-04	169	51	3	17568e7aacfdcd96c469bae57d5ffad04954e9bd
ToppCell	COVID-19_Moderate-Treg\|World / disease group, cell group and cell class	BICDL1 POU6F2 TRAF3IP3	9.50e-04	169	51	3	27ad11239559b025bef582f89b2a83501d9d3993
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TPR FAM184A TOP2A	9.50e-04	169	51	3	2833a8a7094e4d407eb923f2bc59b9b112c6bae4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CDKN2C KIF15 TOP2A	9.50e-04	169	51	3	481e611b5fface58f1630f206c0b04fb54e24011
ToppCell	Dividing_Macrophages-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	CDKN2C KIF15 TOP2A	9.50e-04	169	51	3	bc859a103cad567caf50c3c3882d2d2017807c73
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	COLEC12 MYOCD TG	9.66e-04	170	51	3	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAM184A TLR7 WWC1	9.66e-04	170	51	3	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	390C-Lymphocytic-NK_cells-Proliferating_NK_cell\|390C / Donor, Lineage, Cell class and subclass (all cells)	CDKN2C KIF15 TOP2A	9.66e-04	170	51	3	5319f73cff64f2bb67472c7156ee1d0f006c6fc0
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CDKN2C KIF15 TOP2A	9.66e-04	170	51	3	73601c873b177d5d134618d8e228c51381119f7d
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDKN2C KIF15 TOP2A	9.66e-04	170	51	3	a7184dc41f90caa753860ed0f65a18133f84bc5f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CDKN2C KIF15 TOP2A	9.66e-04	170	51	3	21bfe070e63722672176052b386167ea4c3dc4e5
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF15 AR TOP2A	9.66e-04	170	51	3	6b91d4cbe0697b65bfb2e099e7a9b39ea2fba3a9
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF15 POU2F1 TOP2A	9.66e-04	170	51	3	e08a6c5ac34c456da8c7318f104e06fca585be1f
ToppCell	NS-critical-d_0-4-Lymphoid-B_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FSIP2 ZNF354A CHD7	9.83e-04	171	51	3	bd1ebd9037a740ad8c01c460d778b0973d8b56df
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	BICDL1 MACF1 HELB	9.83e-04	171	51	3	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIF15 TOP2A TG	9.83e-04	171	51	3	4ccd88cf812dd8bfdc55159c6f504e9c84e4f4fc
ToppCell	metastatic_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	BICDL1 TLR7 ZBTB24	9.83e-04	171	51	3	0d14bc9688c427ba2265984987dc3eea195b19eb
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POU2F1 TOP2A HELB	9.99e-04	172	51	3	ba36581ae339191a12a6d3ead39eaf69d78be10e
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	BICDL1 KIF15 ZBTB24	9.99e-04	172	51	3	e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BICDL1 FAM184A CASR	9.99e-04	172	51	3	1565f38266891c3acf49778838de134c5dee5460
Disease	prostate carcinoma	CDKN2C SP3 HLA-DPA1 GRB10 TNRC6B MYOCD CHD7 ZNF236 AR	1.65e-05	891	50	9	EFO_0001663
Disease	Thyroid Dyshormonogenesis 1	DUOX2 TG	4.20e-05	6	50	2	C1848805
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD7	5.88e-05	7	50	2	DOID:0050834 (implicated_via_orthology)
Disease	Goiter	DUOX2 TG	5.88e-05	7	50	2	C0018021
Disease	cortical surface area measurement	CDKN2C COLEC12 SP4 TNRC6A TNRC6B MACF1 CHD7 DENND3 WWC1 TG	7.26e-05	1345	50	10	EFO_0010736
Disease	Congenital Hypothyroidism	DUOX2 TG	2.17e-04	13	50	2	C0010308
Disease	hypothyroidism (implicated_via_orthology)	DUOX2 TG	2.17e-04	13	50	2	DOID:1459 (implicated_via_orthology)
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX2 TG	2.53e-04	14	50	2	DOID:0050328 (implicated_via_orthology)
Disease	grip strength measurement	POU6F2 TNRC6A GRB10 TNRC6B NFAT5	3.12e-04	350	50	5	EFO_0006941
Disease	neuroimaging measurement	TNRC6A GRB10 TNRC6B MACF1 CHD7 DENND3 WWC1 TG	4.02e-04	1069	50	8	EFO_0004346
Disease	systemic scleroderma	HLA-DPA1 GRB10 CHD7	4.10e-04	85	50	3	EFO_0000717
Disease	corpus callosum mid-anterior volume measurement	GRB10 TG	9.61e-04	27	50	2	EFO_0010297
Disease	Liver carcinoma	CDKN2C KIF15 PZP AR TOP2A	1.65e-03	507	50	5	C2239176

Protein segments in the cluster

Peptide	Gene	Start	Entry
LALTQQEQQQQPLTL	CASR	936	P41180
LANIAILNNNLNTLI	HLA-DPA1	91	P20036
QQKLNCQIQQTTLQL	DENND3	351	A2RUS2
QLLDAIQQKLNLSQQ	BICDL1	501	Q6ZP65
TSLQNLQNLQSLQLA	CHD7	2756	Q9P2D1
IQLSQSQTSLQQLQA	FAM184A	706	Q8NB25
LQSSAQLLLQQQQTL	RBM27	681	Q9P2N5
QLLLQQQQTLSHLSQ	RBM27	686	Q9P2N5
FQVDNNNLLLLQQIS	PZP	1296	P20742
LNDLQQLNLSGNNLT	LRRD1	696	A4D1F6
QLINLQNLDLSFNQL	LRRTM2	131	O43300
AQLLQIQTELNNSKQ	KIF15	586	Q9NS87
QLTQQLQSLIPNNNV	LRRC37A2	1476	A6NM11
QLTQQLQSLIPNNNV	LRRC37A	1476	A6NMS7
QLSNLSALLQQQDQK	WWC1	681	Q8IX03
QLQPLQQVNLILSNN	DUOX2	686	Q9NRD8
NNEQPNSILTNNLQL	FSIP2	3731	Q5CZC0
LQQDTSVLQGNLQNQ	COLEC12	181	Q5KU26
GASLLLLQQQQQQQQ	AR	51	P10275
ASQQNQQLETQLSLV	GOLGA6B	481	A6NDN3
LQEQAQTLQQQISSN	NFAT5	746	O94916
NSVSQLQNTIQQLQA	NFAT5	766	O94916
QQNTELQALLQQYLN	DRC1	706	Q96MC2
QQQQLFLQLQILSQQ	MYOCD	291	Q8IZQ8
ANQLQQLQSQLAHQT	MACF1	1526	Q9UPN3
LLLQQAQAQAQLLAA	POU2F1	121	P14859
AQNLLTQLPQQSQAN	POU2F1	221	P14859
TQLPQQSQANLLQSQ	POU2F1	226	P14859
TLQALQQNLQNLQSL	CHD9	2671	Q3L8U1
QQNLQNLQSLQVTAG	CHD9	2676	Q3L8U1
LTSLLQNNVNVNAQN	CDKN2C	21	P42773
LQELDTLQQQLDSQN	IFT74	241	Q96LB3
QQPLQSEQQLAQLTQ	CCDC107	101	Q8WV48
SEQQLAQLTQQLAQT	CCDC107	106	Q8WV48
AALSSQQQQQLALLL	GIGYF2	646	Q6Y7W6
QQQQQLALLLQQFQT	GIGYF2	651	Q6Y7W6
QQSNGSQTQLLQNFL	GRB10	271	Q13322
LLNLDKTLNQLQQAQ	LAMB4	1566	A4D0S4
TLLQENNLQNAKTSQ	HELB	726	Q8NG08
VTSLELLNLNNNDIQ	LRRC30	231	A6NM36
NIQSLSNLQVQNAGL	SP4	476	Q02446
SNLQVQNAGLSQQLT	SP4	481	Q02446
IQNSQLQLQLNQDLS	PKNOX1	236	P55347
LQNLQATSSLNSQLQ	POU6F2	166	P78424
ATSSLNSQLQQLQLQ	POU6F2	171	P78424
TQLDQNLLNSENLNN	SSH1	606	Q8WYL5
LQGLLQNQSLQLQEQ	TRAF3IP3	416	Q9Y228
QNQSLQLQEQEKLLT	TRAF3IP3	421	Q9Y228
LANNNLQILNINKSD	NCAM2	166	O15394
NASLTNNQNLIQSLK	TPR	1386	P12270
ASGQNISQQALQNLQ	SP3	426	Q02447
ISQQALQNLQLQLNP	SP3	431	Q02447
NNLNQLQILDLSGNC	TLR7	246	Q9NYK1
TQQPEQLQNLILSAQ	ZBTB24	596	O43167
LAQNFVGSNNLNLLQ	TOP2A	771	P11388
LLEQQQAQLQQQLLL	ZNF853	266	P0CG23
QQTLQQGNLLAQQLT	ZNF236	1396	Q9UL36
IQGNSLKQNSQLLNQ	ZNF354A	191	O60765
SLLQQITENPQLIQN	UBQLN2	371	Q9UHD9
LNQVIVNGNQSLSSQ	TG	1861	P01266
LNQLSQLNQLSQISQ	TNRC6A	1401	Q8NDV7
QLNQLSQISQLQRLL	TNRC6A	1406	Q8NDV7
ACQLLLQQQQQQQLL	TNRC6B	1281	Q9UPQ9