Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	IQ_SEC7_PH	IQSEC3 IQSEC2	9.64e-06	3	34	2	PF16453
Domain	IQSEC_PH	IQSEC3 IQSEC2	9.64e-06	3	34	2	IPR033742
Domain	UBA	HUWE1 LATS2 BRSK1	6.94e-05	44	34	3	IPR015940
Domain	UBA	HUWE1 LATS2 BRSK1	8.46e-05	47	34	3	PS50030
Domain	Sec7	IQSEC3 IQSEC2	3.33e-04	15	34	2	PF01369
Domain	Sec7_alpha_orthog	IQSEC3 IQSEC2	3.33e-04	15	34	2	IPR023394
Domain	-	IQSEC3 IQSEC2	3.33e-04	15	34	2	1.10.1000.11
Domain	Sec7	IQSEC3 IQSEC2	3.80e-04	16	34	2	SM00222
Domain	Sec7_dom	IQSEC3 IQSEC2	3.80e-04	16	34	2	IPR000904
Domain	SEC7	IQSEC3 IQSEC2	3.80e-04	16	34	2	PS50190
Domain	HECT	HUWE1 HECW1	1.10e-03	27	34	2	PF00632
Domain	HECTc	HUWE1 HECW1	1.10e-03	27	34	2	SM00119
Domain	HECT_dom	HUWE1 HECW1	1.10e-03	27	34	2	IPR000569
Domain	HECT	HUWE1 HECW1	1.10e-03	27	34	2	PS50237
Domain	UBA	HUWE1 LATS2	1.95e-03	36	34	2	PF00627
Domain	UBA-like	HUWE1 LATS2	6.04e-03	64	34	2	IPR009060
Domain	IQ	IQSEC3 IQSEC2	7.39e-03	71	34	2	PF00612
Domain	Homeobox_metazoa	HOXC4 MNX1	1.17e-02	90	34	2	IPR020479
Domain	IQ_motif_EF-hand-BS	IQSEC3 IQSEC2	1.17e-02	90	34	2	IPR000048
Domain	IQ	IQSEC3 IQSEC2	1.24e-02	93	34	2	PS50096
Domain	PH	IQSEC3 IQSEC2 SPATA13	1.39e-02	278	34	3	SM00233
Domain	PH_DOMAIN	IQSEC3 IQSEC2 SPATA13	1.40e-02	279	34	3	PS50003
Domain	PH_domain	IQSEC3 IQSEC2 SPATA13	1.42e-02	280	34	3	IPR001849
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CBLL1 CACNA1A IQSEC3 CHD7 SFPQ HUWE1 BRSK1 HECW1 SIPA1L3 IQSEC2 SPATA13	3.07e-09	963	37	11	28671696
Pubmed	SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation.	HELZ2 SFPQ	1.10e-06	2	37	2	34052659
Pubmed	Novel roles of hakai in cell proliferation and oncogenesis.	CBLL1 SFPQ	1.10e-06	2	37	2	19535458
Pubmed	HELZ2 promotes K63-linked polyubiquitination of c-Myc to induce retinoblastoma tumorigenesis.	HELZ2 HUWE1	3.30e-06	3	37	2	34761308
Pubmed	Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development.	SOX1 MNX1	6.02e-05	11	37	2	31822965
Pubmed	MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord.	SOX1 MNX1	7.22e-05	12	37	2	28337978
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	HELZ2 CHD7 HECW1 SIPA1L3	9.53e-05	225	37	4	12168954
Pubmed	Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.	SOX1 TET3	1.15e-04	15	37	2	27930333
Pubmed	Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.	SOX1 MNX1	1.15e-04	15	37	2	15893981
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	HUWE1 HECW1	1.31e-04	16	37	2	25723849
Pubmed	Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons.	HOXC4 MNX1	1.67e-04	18	37	2	23359544
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	IQSEC3 IQSEC2	1.86e-04	19	37	2	30674481
Pubmed	Sustained Hox5 gene activity is required for respiratory motor neuron development.	HOXC4 MNX1	2.07e-04	20	37	2	23103965
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	SOX1 FOXD4	2.28e-04	21	37	2	9449667
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	SFPQ ICE2 SIPA1L3	3.00e-04	122	37	3	30773093
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	CHD7 SFPQ LATS2 FOXD4	3.09e-04	306	37	4	18973680
Pubmed	The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.	SOX1 MNX1	3.25e-04	25	37	2	23223237
Pubmed	Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.	SOX1 MNX1	3.52e-04	26	37	2	28684471
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HUWE1 HECW1	3.52e-04	26	37	2	26949039
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	CBLL1 SFPQ CHERP YTHDC1 MNX1 SIPA1L3	3.93e-04	922	37	6	27609421
Pubmed	Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.	SOX1 MNX1	4.09e-04	28	37	2	24995796
Pubmed	The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism.	DAZL SFPQ	4.39e-04	29	37	2	34175335
Pubmed	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.	SOX1 MNX1	5.35e-04	32	37	2	19286674
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	CHD7 SFPQ HUWE1 YTHDC1	5.58e-04	358	37	4	32460013
Pubmed	Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.	HOXC4 MNX1	5.69e-04	33	37	2	18662545
Pubmed	Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.	SOX1 MNX1	5.69e-04	33	37	2	25179941
Pubmed	FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism.	SOX1 MNX1	6.05e-04	34	37	2	18590716
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	HELZ2 CHD7 SFPQ HUWE1 CHERP	6.09e-04	653	37	5	22586326
Pubmed	Global control of motor neuron topography mediated by the repressive actions of a single hox gene.	HOXC4 MNX1	6.78e-04	36	37	2	20826310
Pubmed	PRC1 sustains the integrity of neural fate in the absence of PRC2 function.	HOXC4 MNX1	7.56e-04	38	37	2	34994686
Pubmed	The protein interaction landscape of the human CMGC kinase group.	HUWE1 CHERP YTHDC1 ICE2 SIPA1L3	8.06e-04	695	37	5	23602568
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	HELZ2 CBLL1 TAF8 CHD7 YTHDC1 SIPA1L3 DUSP11	8.93e-04	1497	37	7	31527615
Pubmed	The DNA sequence of the human X chromosome.	HUWE1 AMMECR1 CBLL2 IQSEC2	8.99e-04	407	37	4	15772651
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	HELZ2 CBLL1 CHD7 SFPQ CHERP YTHDC1	9.10e-04	1082	37	6	38697112
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	SFPQ CHERP LATS2	9.31e-04	180	37	3	35198878
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	SOX1 HELZ2 PRR14 BRSK1 SIPA1L3	1.02e-03	732	37	5	34732716
Cytoband	2p13.1	TET3 DUSP11	3.49e-04	34	37	2	2p13.1
Cytoband	Xp11.22	HUWE1 IQSEC2	8.81e-04	54	37	2	Xp11.22
GeneFamily	HOXL subclass homeoboxes	HOXC4 MNX1	1.21e-03	52	18	2	518
Coexpression	GSE22601_CD4_SINGLE_POSITIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_DN	HELZ2 PRR14 TAF8 YTHDC1 DUSP11	6.63e-06	200	35	5	M6251
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	SOX1 FLI1 HOXC4 MNX1 FOXD4	8.40e-06	210	35	5	M2010
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	SOX1 FLI1 HOXC4 MNX1 FOXD4	9.85e-06	217	35	5	MM861
Coexpression	MATSUMIYA_PBMC_MODIFIED_VACCINIA_ANKARA_VACCINE_AGE_18_55YO_VACCINATED_VS_CONTROL_TREATED_IN_VITRO_WITH_WILD_TYPE_MVA_6HR_UP	C2orf69 TAF8 ICE2	1.27e-05	34	35	3	M41195
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l8\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX1 CHD7 SPATA13 FOXD4	7.78e-06	153	37	4	338684d420b01e32918fa19048ccdda234942ce1
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX1 IQSEC3 HOXC4 NALF2	1.68e-05	186	37	4	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	HELZ2 CMPK2 SFPQ YTHDC1	2.10e-05	197	37	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	HELZ2 CMPK2 SFPQ YTHDC1	2.14e-05	198	37	4	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HELZ2 CMPK2 SFPQ YTHDC1	2.14e-05	198	37	4	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	Transverse-(1)_T_cell-(16)_Tfh\|Transverse / shred on region, Cell_type, and subtype	SLC66A2 TET3 ICE2 SPATA13	2.19e-05	199	37	4	aa31e26d48066f865ca33251a33a28934c0a7a44
ToppCell	Transverse-T_cell-Tfh\|Transverse / Region, Cell class and subclass	SLC66A2 TET3 ICE2 SPATA13	2.19e-05	199	37	4	cbef8f95edf2e86e16c448a76068d7ed8f6b7748
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HELZ2 CMPK2 SFPQ YTHDC1	2.23e-05	200	37	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Computational	RNA splicing.	SFPQ CHERP DUSP11	1.91e-04	65	19	3	MODULE_183
Disease	eosinophil count	HELZ2 FLI1 CHD7 CHERP TET3 ICE2 SIPA1L3	1.32e-03	1488	34	7	EFO_0004842
Disease	disease recurrence, colon carcinoma	SOD3 SPATA13	1.59e-03	51	34	2	EFO_0004952, EFO_1001950

Protein segments in the cluster

Peptide	Gene	Start	Entry
HHHHPPPPDKDRYAQ	CACNA1A	2216	O00555
IPQVYHGQIHQPLPH	BAAT	266	Q14032
QPPPQHHVLYFPGDV	C2orf69	96	Q8N8R5
SPHHIIPQKQHYAPP	CBLL2	271	Q8N7E2
PHSQYHTPPVPQVPH	CHD7	101	Q9P2D1
PPAAGLYVPHPHHKQ	LATS2	306	Q9NRM7
HHHYPTIDEPLPPNW	HECW1	821	Q76N89
YPQVQGAHPAHPADP	MNX1	186	P50219
PQFAPHGRHPLHQPT	IQSEC2	1351	Q5JU85
YHPHHDPPGRVSNKP	NALF2	401	O75949
QRHQPTPGAHLPHPF	FOXD4	201	Q12950
IHVHYPGNRQPNPPL	HUWE1	2561	Q7Z6Z7
HPAPDRPPRQHHGQL	IQSEC3	106	Q9UPP2
PPPPLQHVPHEHYNQ	CBLL1	241	Q75N03
PAPAPAHHHPEYQGQ	CBLL1	311	Q75N03
HLPPAHHPVYQWPED	CMPK2	351	Q5EBM0
PPLEFPVHQYQPGDH	ZNF561-AS1	66	K7EIQ3
PYHIHHGRIPCTFPP	ICE2	916	Q659A1
ENPHVYQRHHLPPPG	DUSP11	316	O75319
HFRGPFPPHQQHPQF	CHERP	521	Q8IWX8
YPNPNVPRHPNTHVP	FLI1	431	Q01543
QHHHQELYPPPPPRP	HOXC4	46	P09017
HPHPPQHAQYVGPYR	BRSK1	21	Q8TDC3
AYHVQPRPLVFNHPP	DAZL	121	Q92904
HARGKVPPHPRHYPL	HELZ2	766	Q9BYK8
PGPQVYHRVHHRPPS	PRR23D1	256	E9PI22
AGQNRPHPPHIPSHF	TAF8	136	Q7Z7C8
YHQDPVHRQPPASPP	PRR14	81	Q9BWN1
ARRQHQHPHPPVGPG	SIPA1L3	1586	O60292
PHAHPHNPQPMHRYD	SOX1	236	O00570
PGPQVYHRVHHRPPS	PRR23D2	256	P0DMB1
HHFQNGIGHPLPPYN	AMMECR1	316	Q9Y4X0
PRGGRQHHPPYHQQH	SFPQ	241	P23246
YNRCPVAPPHQGLHP	SPATA13	596	Q96N96
HYNPLAVPHPQHPGD	SOD3	131	P08294
HPTPHHQQPAYPGPK	TET3	1351	O43151
QAHPPYSGHHPVPHE	YTHDC1	631	Q96MU7
FARHPQKPAPHAVHP	SLC66A2	251	Q8N2U9