Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprolactin receptor binding

CSH1 CSH2 CSHL1

2.31e-067823GO:0005148
GeneOntologyMolecularFunctiongrowth hormone receptor binding

CSH1 CSH2 CSHL1

7.85e-0610823GO:0005131
GeneOntologyMolecularFunctionhormone receptor binding

CSH1 CSH2 CSHL1

3.64e-0434823GO:0051427
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ATP11B ABCA7

5.89e-049822GO:0090556
GeneOntologyMolecularFunctiongrowth factor activity

CSH1 CSH2 CSHL1 GRN CCN2

7.34e-04173825GO:0008083
GeneOntologyMolecularFunctionunmethylated CpG binding

KMT2B FBXL19

7.34e-0410822GO:0045322
GeneOntologyBiologicalProcesspositive regulation of hormone biosynthetic process

ARNT CSH1 CSH2 CSHL1

8.59e-0719824GO:0046886
GeneOntologyBiologicalProcesspositive regulation of hormone metabolic process

ARNT CSH1 CSH2 CSHL1

3.24e-0626824GO:0032352
GeneOntologyBiologicalProcessregulation of hormone metabolic process

ARNT CSH1 CSH2 CSHL1 KCNMA1

3.41e-0658825GO:0032350
GeneOntologyBiologicalProcessregulation of hormone biosynthetic process

ARNT CSH1 CSH2 CSHL1

1.24e-0536824GO:0046885
GeneOntologyBiologicalProcesspositive regulation of steroid hormone biosynthetic process

CSH1 CSH2 CSHL1

1.68e-0513823GO:0090031
GeneOntologyBiologicalProcessregulation of steroid hormone biosynthetic process

CSH1 CSH2 CSHL1

1.15e-0424823GO:0090030
GeneOntologyBiologicalProcessgrowth hormone receptor signaling pathway

CSH1 CSH2 CSHL1

1.47e-0426823GO:0060396
GeneOntologyBiologicalProcesscellular response to growth hormone stimulus

CSH1 CSH2 CSHL1

1.65e-0427823GO:0071378
GeneOntologyCellularComponentgrowth hormone receptor complex

CSH1 CSH2 CSHL1

1.20e-066833GO:0070195
MousePhenoincreased circulating ghrelin level

CSH1 CSH2 CSHL1 GRN

2.32e-0712674MP:0011612
MousePhenoabnormal circulating ghrelin level

CSH1 CSH2 CSHL1 GRN

6.32e-0715674MP:0011611
MousePhenodecreased pituitary gland weight

CSH1 CSH2 CSHL1

5.79e-068673MP:0008938
MousePhenoabsent somatotrophs

CSH1 CSH2 CSHL1

8.66e-069673MP:0008330
MousePhenoabsent lactotrophs

CSH1 CSH2 CSHL1

8.66e-069673MP:0008333
MousePhenodelayed vaginal opening

NCOA3 CSH1 CSH2 CSHL1

9.05e-0628674MP:0002636
MousePhenoabnormal timing of vaginal opening

NCOA3 CSH1 CSH2 CSHL1

1.38e-0531674MP:0020150
MousePhenoabnormal pituitary gland weight

CSH1 CSH2 CSHL1

2.24e-0512673MP:0008937
MousePhenoabnormal brown adipose tissue amount

NCOA3 STAG1 CSH1 CSH2 CSHL1

4.46e-0582675MP:0001778
MousePhenodecreased lactotroph cell number

CSH1 CSH2 CSHL1

6.82e-0517673MP:0008332
MousePhenoabnormal diencephalon morphology

TRAF6 CELSR3 CSH1 CSH2 CSHL1 SMARCC1 GRN SSPOP

8.50e-05298678MP:0000830
MousePhenodelayed sexual maturation

NCOA3 CSH1 CSH2 CSHL1

8.68e-0549674MP:0001938
MousePhenoabnormal lactotroph morphology

CSH1 CSH2 CSHL1

9.65e-0519673MP:0008323
MousePhenodecreased somatotroph cell number

CSH1 CSH2 CSHL1

1.32e-0421673MP:0008329
MousePhenodisproportionate dwarf

NCOA3 CSH1 CSH2 CSHL1

1.57e-0457674MP:0002427
MousePhenosmall adenohypophysis

CSH1 CSH2 CSHL1

1.74e-0423673MP:0008321
MousePhenoabnormal somatotroph morphology

CSH1 CSH2 CSHL1

1.98e-0424673MP:0008322
MousePhenosmall pituitary gland

CSH1 CSH2 CSHL1

3.89e-0430673MP:0005361
MousePhenoabnormal sexual maturation

NCOA3 CSH1 CSH2 CSHL1

4.31e-0474674MP:0001937
MousePhenoabnormal white adipose tissue amount

NCOA3 CSH1 CSH2 CSHL1 ABCA7

5.15e-04138675MP:0001781
MousePhenoabnormal platelet morphology

PPP4R1 NCOA3 PPP2R2B ATG4B CSH1 CSH2 CSHL1 SVIL GRN FBXL19

5.36e-046006710MP:0004720
MousePhenosmall lung saccule

ZSWIM8 CCN2

6.22e-048672MP:0010827
DomainSOMATOTROPIN_2

CSH1 CSH2 CSHL1

1.50e-066803PS00338
DomainHormone_1

CSH1 CSH2 CSHL1

1.50e-066803PF00103
DomainSOMATOTROPIN_1

CSH1 CSH2 CSHL1

1.50e-066803PS00266
DomainSomatotropin

CSH1 CSH2 CSHL1

2.62e-067803IPR001400
DomainVWFC_1

ZAN CHRDL1 CCN2 SSPOP

1.66e-0536804PS01208
DomainSMARCC_C

SMARCC1 SMARCC2

1.81e-052802IPR032451
DomainSMARCC_N

SMARCC1 SMARCC2

1.81e-052802IPR032450
DomainSWIRM-assoc

SMARCC1 SMARCC2

1.81e-052802IPR032448
DomainSWIRM-assoc_2

SMARCC1 SMARCC2

1.81e-052802PF16496
DomainSWIRM-assoc_1

SMARCC1 SMARCC2

1.81e-052802PF16495
DomainSWIRM-assoc_3

SMARCC1 SMARCC2

1.81e-052802PF16498
DomainVWC

ZAN CHRDL1 CCN2 SSPOP

2.06e-0538804SM00214
DomainVWFC_2

ZAN CHRDL1 CCN2 SSPOP

2.06e-0538804PS50184
DomainVWF_dom

ZAN CHRDL1 CCN2 SSPOP

3.09e-0542804IPR001007
DomainPP2A_PR55

PPP2R2B PPP2R2D

1.08e-044802IPR000009
DomainPP2A_PR55_CS

PPP2R2B PPP2R2D

1.08e-044802IPR018067
DomainPR55_2

PPP2R2B PPP2R2D

1.08e-044802PS01025
DomainPR55_1

PPP2R2B PPP2R2D

1.08e-044802PS01024
DomainTSP_1

CILP ADAMTS20 CCN2 SSPOP

1.53e-0463804PF00090
DomainTSP1

CILP ADAMTS20 CCN2 SSPOP

1.73e-0465804SM00209
DomainTSP1_rpt

CILP ADAMTS20 CCN2 SSPOP

1.73e-0465804IPR000884
DomainTSP1

CILP ADAMTS20 CCN2 SSPOP

1.73e-0465804PS50092
DomainSomatotropin_CS

CSH1 CSHL1

1.80e-045802IPR018116
DomainHEAT_REPEAT

PPP4R1 MROH7 HEATR5A TEX10

2.31e-0470804PS50077
DomainSWIRM

SMARCC1 SMARCC2

2.69e-046802PS50934
DomainSWIRM

SMARCC1 SMARCC2

2.69e-046802PF04433
DomainSWIRM

SMARCC1 SMARCC2

2.69e-046802IPR007526
DomainZnf_CXXC

KMT2B FBXL19

9.72e-0411802IPR002857
DomainZF_CXXC

KMT2B FBXL19

9.72e-0411802PS51058
DomainFrizzled

FZD7 FZD2

9.72e-0411802IPR000539
DomainFrizzled

FZD7 FZD2

9.72e-0411802PF01534
Domainzf-CXXC

KMT2B FBXL19

9.72e-0411802PF02008
DomainFrizzled

FZD7 FZD2

9.72e-0411802SM01330
DomainARM-like

PPP4R1 STK36 STAG1 MROH7 HEATR5A TEX10

1.06e-03270806IPR011989
DomainHEAT

PPP4R1 STK36 TEX10

1.14e-0348803PF02985
DomainTIL

ZAN SSPOP

1.16e-0312802PF01826
DomainC8

ZAN SSPOP

1.16e-0312802PF08742
Domain4_helix_cytokine_core

CSH1 CSH2 CSHL1

1.36e-0351803IPR012351
DomainUnchr_dom_Cys-rich

ZAN SSPOP

1.37e-0313802IPR014853
DomainC8

ZAN SSPOP

1.37e-0313802SM00832
DomainTIL_dom

ZAN SSPOP

1.59e-0314802IPR002919
DomainHEAT

PPP4R1 STK36 TEX10

1.97e-0358803IPR000357
DomainVWD

ZAN SSPOP

2.09e-0316802SM00216
DomainVWF_type-D

ZAN SSPOP

2.09e-0316802IPR001846
DomainVWFD

ZAN SSPOP

2.09e-0316802PS51233
DomainVWD

ZAN SSPOP

2.09e-0316802PF00094
DomainFrizzled/SFRP

FZD7 FZD2

2.09e-0316802IPR015526
DomainGPCR_2_secretin-like

FZD7 CELSR3 FZD2

2.17e-0360803IPR000832
DomainGPCR_2-like

FZD7 CELSR3 FZD2

2.17e-0360803IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD7 CELSR3 FZD2

2.28e-0361803PS50261
DomainHEAT_type_2

PPP4R1 TEX10

2.36e-0317802IPR021133
Domain-

PPP4R1 STK36 MROH7 HEATR5A TEX10

2.65e-032228051.25.10.10
DomainCTCK_1

CCN2 SSPOP

2.65e-0318802PS01185
DomainVWC_out

ZAN SSPOP

2.96e-0319802SM00215
DomainFRI

FZD7 FZD2

3.27e-0320802SM00063
DomainARM-type_fold

PPP4R1 STK36 STAG1 MROH7 HEATR5A TEX10

3.33e-03339806IPR016024
DomainFA58C

SSPOP DCBLD2

3.61e-0321802SM00231
Domain-

FZD7 FZD2

3.61e-03218021.10.2000.10
DomainFA58C_3

SSPOP DCBLD2

3.61e-0321802PS50022
DomainFA58C_1

SSPOP DCBLD2

3.61e-0321802PS01285
DomainFA58C_2

SSPOP DCBLD2

3.61e-0321802PS01286
Domain4_helix_cytokine-like_core

CSH1 CSH2 CSHL1

3.94e-0374803IPR009079
DomainQuino_amine_DH_bsu

WDR36 VPS8

3.96e-0322802IPR011044
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

CSH1 CSH2 CSHL1

2.03e-0513603MM14516
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

CSH1 CSH2 CSHL1

3.95e-0516603MM15710
PathwayBIOCARTA_LONGEVITY_PATHWAY

CSH1 CSH2 CSHL1

6.77e-0519603MM1513
PathwayREACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN

CSH1 CSH2 CSHL1

7.94e-0520603MM15070
PathwayBIOCARTA_AKT_PATHWAY

CSH1 CSH2 CSHL1

1.78e-0426603MM1345
PathwayBIOCARTA_TFF_PATHWAY

CSH1 CSH2 CSHL1

2.48e-0429603MM1522
PathwayBIOCARTA_GH_PATHWAY

CSH1 CSH2 CSHL1

3.65e-0433603MM1404
Pubmed

Regulation of somatic growth by the p160 coactivator p/CIP.

NCOA3 CSH1 CSH2 CSHL1

3.76e-09983411087842
Pubmed

The human growth hormone gene locus: structure, evolution, and allelic variations.

CSH1 CSH2 CSHL1

1.31e-0838333030680
Pubmed

Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster.

CSH1 CSH2 CSHL1

5.23e-0848331378436
Pubmed

Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.

NCOA3 CSH1 CSH2 CSHL1

5.37e-081683410882104
Pubmed

Central growth hormone action regulates metabolism during pregnancy.

CSH1 CSH2 CSHL1

1.31e-07583331479305
Pubmed

Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.

CSH1 CSH2 CSHL1

1.31e-07583310767558
Pubmed

Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency.

CSH1 CSH2 CSHL1

1.31e-0758338496314
Pubmed

Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples.

CSH1 CSH2 CSHL1

1.31e-07583321045135
Pubmed

Analysis of gender difference of cardiac risk biomarkers using hGH-transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583316508206
Pubmed

Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference.

CSH1 CSH2 CSHL1

1.31e-07583318006625
Pubmed

Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.

CSH1 CSH2 CSHL1

1.31e-07583315616010
Pubmed

Nitric oxide stimulates embryonic somatotroph differentiation and growth hormone mRNA and protein expression through a cyclic guanosine monophosphate-independent mechanism.

CSH1 CSH2 CSHL1

1.31e-07583319019400
Pubmed

The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?

CSH1 CSH2 CSHL1

1.31e-07583332556100
Pubmed

High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice.

CSH1 CSH2 CSHL1

1.31e-0758331525063
Pubmed

Obesity and elevated plasma leptin concentration in oMT1A-o growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583311346667
Pubmed

Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583312010633
Pubmed

Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.

CSH1 CSH2 CSHL1

1.31e-07583317626886
Pubmed

Growth hormone prevents the development of autoimmune diabetes.

CSH1 CSH2 CSHL1

1.31e-07583324218587
Pubmed

Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.

CSH1 CSH2 CSHL1

1.31e-07583319359380
Pubmed

Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.

CSH1 CSH2 CSHL1

1.31e-0758339546108
Pubmed

Transgene transmission to progeny by oMt1a-oGH transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583316201410
Pubmed

Growth hormone stimulates the selective trafficking of thymic CD4+CD8- emigrants to peripheral lymphoid organs.

CSH1 CSH2 CSHL1

1.31e-07583315316240
Pubmed

Genes that prolong life: relationships of growth hormone and growth to aging and life span.

CSH1 CSH2 CSHL1

1.31e-07583311487592
Pubmed

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583311318985
Pubmed

Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.

CSH1 CSH2 CSHL1

1.31e-07583317301034
Pubmed

Growth hormone action in the developing neural retina: a proteomic analysis.

CSH1 CSH2 CSHL1

1.31e-07583318203262
Pubmed

Identification of the glomerular podocyte as a target for growth hormone action.

CSH1 CSH2 CSHL1

1.31e-07583317272398
Pubmed

Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis.

CSH1 CSH2 CSHL1

1.31e-07583320707609
Pubmed

Assignment of the porcine growth hormone gene to chromosome 12.

CSH1 CSH2 CSHL1

1.31e-0758332249485
Pubmed

Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.

CSH1 CSH2 CSHL1

1.31e-07583317242167
Pubmed

A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice.

CSH1 CSH2 CSHL1

1.31e-07583318180319
Pubmed

Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.31e-0758331874564
Pubmed

Cloning and characterisation of the GH gene from the common dolphin (Delphinus delphis).

CSH1 CSH2 CSHL1

1.31e-07583312225773
Pubmed

Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.

CSH1 CSH2 CSHL1

1.31e-07583332100023
Pubmed

The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.

CSH1 CSH2 CSHL1

1.31e-0758333780533
Pubmed

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583310395045
Pubmed

Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes.

CSH1 CSH2 CSHL1

1.31e-07583324190208
Pubmed

Brief report: short stature caused by a mutant growth hormone.

CSH1 CSH2 CSHL1

1.31e-0758338552145
Pubmed

Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.

CSH1 CSH2 CSHL1

1.31e-07583336762426
Pubmed

High molecular weight isoforms of growth hormone in cells of the immune system.

CSH1 CSH2 CSHL1

1.31e-07583321741628
Pubmed

Structure of the growth hormone-encoding gene and its promoter in mice.

CSH1 CSH2 CSHL1

1.31e-0758338647448
Pubmed

Thiol-Disulfide Exchange in Human Growth Hormone.

CSH1 CSH2 CSHL1

1.31e-07583326887678
Pubmed

Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies.

CSH1 CSH2 CSHL1

1.31e-07583310810296
Pubmed

The role of growth hormone in fetal mouse reproductive tract differentiation.

CSH1 CSH2 CSHL1

1.31e-0758338756530
Pubmed

GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.

CSH1 CSH2 CSHL1

1.31e-07583331099824
Pubmed

Somatotropin transgenic mice have reduced jejunal active glucose transport rates.

CSH1 CSH2 CSHL1

1.31e-0758337965203
Pubmed

Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.

CSH1 CSH2 CSHL1

1.31e-0758331980158
Pubmed

Vitamin D3 cannot revert desensitization of growth hormone (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues.

CSH1 CSH2 CSHL1

1.31e-07583317881271
Pubmed

Neural growth hormone implicated in body weight sex differences.

CSH1 CSH2 CSHL1

1.31e-07583323861378
Pubmed

Growth hormone increases low-density lipoprotein receptor and HMG-CoA reductase mRNA expression in mesangial cells.

CSH1 CSH2 CSHL1

1.31e-07583312759574
Pubmed

Growth hormone production and action in N1E-115 neuroblastoma cells.

CSH1 CSH2 CSHL1

1.31e-07583319301152
Pubmed

Adipocyte insensitivity to insulin in growth hormone-transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583311350075
Pubmed

Transgenic mice overexpressing growth hormone (GH) have reduced or increased cardiac apoptosis through activation of multiple GH-dependent or -independent cell death pathways.

CSH1 CSH2 CSHL1

1.31e-07583318617616
Pubmed

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.

CSH1 CSH2 CSHL1

1.31e-07583317347312
Pubmed

Growth hormone and fertility in oMt1a-oGH transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583311570960
Pubmed

Promoter shuffling has occurred during the evolution of the vertebrate growth hormone gene.

CSH1 CSH2 CSHL1

1.31e-07583310974531
Pubmed

Pleiotropic effects of growth hormone signaling in aging.

CSH1 CSH2 CSHL1

1.31e-07583321852148
Pubmed

Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender.

CSH1 CSH2 CSHL1

1.31e-07583312175649
Pubmed

Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation.

CSH1 CSH2 CSHL1

1.31e-07583315070902
Pubmed

Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone.

CSH1 CSH2 CSHL1

1.31e-07583323428905
Pubmed

A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity.

CSH1 CSH2 CSHL1

1.31e-07583314726450
Pubmed

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.

CSH1 CSH2 CSHL1

1.31e-07583324758742
Pubmed

Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes.

CSH1 CSH2 CSHL1

1.31e-07583310076541
Pubmed

Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads.

CSH1 CSH2 CSHL1

1.31e-07583310594738
Pubmed

Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes.

CSH1 CSH2 CSHL1

1.31e-07583323639351
Pubmed

Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood.

CSH1 CSH2 CSHL1

1.31e-07583321098290
Pubmed

Cardiac expression of adenine nucleotide translocase-1 in transgenic mice overexpressing bovine GH.

CSH1 CSH2 CSHL1

1.31e-07583317761891
Pubmed

Age-related changes in body composition of bovine growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.31e-07583318948397
Pubmed

The human growth hormone locus: nucleotide sequence, biology, and evolution.

CSH1 CSH2 CSHL1

2.61e-0768332744760
Pubmed

Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.

CSH1 CSH2 CSHL1

2.61e-07683312399427
Pubmed

Transgenic mice over-expressing galanin exhibit pituitary adenomas and increased secretion of galanin, prolactin and growth hormone.

CSH1 CSH2 CSHL1

2.61e-07683314596666
Pubmed

GH modulates hepatic epidermal growth factor signaling in the mouse.

CSH1 CSH2 CSHL1

2.61e-07683320032199
Pubmed

Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.

CSH1 CSH2 CSHL1

2.61e-07683311316754
Pubmed

The use of transgenic mice to analyze the role of accessory factor two in the regulation of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes.

CSH1 CSH2 CSHL1

2.61e-07683311309401
Pubmed

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice.

CSH1 CSH2 CSHL1

2.61e-07683323150490
Pubmed

Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy.

CSH1 CSH2 CSHL1

2.61e-0768332991252
Pubmed

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.

CSH1 CSH2 CSHL1

2.61e-07683325017732
Pubmed

Third party data gene data set of eutherian growth hormone genes.

CSH1 CSH2 CSHL1

2.61e-07683326697363
Pubmed

Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness.

CSH1 CSH2 CSHL1

2.61e-07683310689811
Pubmed

Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse.

CSH1 CSH2 CSHL1

2.61e-07683315985453
Pubmed

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes.

CSH1 CSH2 CSHL1

2.61e-07683320863500
Pubmed

An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth.

CSH1 CSH2 CSHL1

2.61e-07683324949662
Pubmed

Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1.

CSH1 CSH2 CSHL1

2.61e-07683333539533
Pubmed

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

CSH1 CSH2 CSHL1

2.61e-07683320231469
Pubmed

Growth hormone resistance: clinical states and animal models.

CSH1 CSH2 CSHL1

2.61e-07683310556764
Pubmed

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.

CSH1 CSH2 CSHL1

2.61e-07683312208853
Pubmed

Involvement of growth hormone as a regulating factor in sex differences of mouse hepatic aldehyde oxidase.

CSH1 CSH2 CSHL1

2.61e-0768339175714
Pubmed

Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse.

CSH1 CSH2 CSHL1

2.61e-07683316141391
Pubmed

Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.

CSH1 CSH2 CSHL1

2.61e-07683318618017
Pubmed

Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.

CSH1 CSH2 CSHL1

2.61e-07683312166626
Pubmed

Growth hormone expression in murine bone marrow cells is independent of the pituitary transcription factor Pit-1.

CSH1 CSH2 CSHL1

2.61e-0768339275086
Pubmed

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

CSH1 CSH2 CSHL1

2.61e-07683323782652
Pubmed

Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.

CSH1 CSH2 CSHL1

2.61e-07683314759511
Pubmed

Age related changes in gene expression within the cochlea of C57BL/6J mice.

CSH1 CSH2 CSHL1

2.61e-07683323010755
Pubmed

Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice.

CSH1 CSH2 CSHL1

2.61e-07683325645493
Pubmed

Administration of human insulin-like growth factor-binding protein-1 increases circulating levels of growth hormone in mice.

CSH1 CSH2 CSHL1

2.61e-07683315166120
Pubmed

Osteocalcin induces growth hormone/insulin-like growth factor-1 system by promoting testosterone synthesis in male mice.

CSH1 CSH2 CSHL1

2.61e-07683324691732
Pubmed

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

CSH1 CSH2 CSHL1

2.61e-07683321725989
Pubmed

CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment.

CSH1 CSH2 CSHL1

2.61e-07683338951485
Pubmed

Evidence that growth hormone exerts a feedback effect on stomach ghrelin production and secretion.

CSH1 CSH2 CSHL1

2.61e-07683314530511
InteractionCSHL1 interactions

CSH1 CSH2 CSHL1

2.25e-067823int:CSHL1
InteractionSAMD9 interactions

TRAF6 SMARCC1 SMARCC2 NARS2

4.84e-0628824int:SAMD9
InteractionCSH2 interactions

CSH1 CSH2 CSHL1

2.85e-0515823int:CSH2
InteractionSMAD9 interactions

ARNT STAG1 CSH1 CSH2 VPS8 GRN

3.78e-05153826int:SMAD9
InteractionCSH1 interactions

CSH1 CSH2 CSHL1

5.07e-0518823int:CSH1
Cytoband17q24.2

CSH1 CSH2 CSHL1

2.23e-053083317q24.2
GeneFamilyGrowth hormone family

CSH1 CSH2 CSHL1

6.22e-0765831175
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD7 FZD2

5.46e-0411582286
GeneFamilyZinc fingers CXXC-type

KMT2B FBXL19

6.54e-0412582136
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R2B PPP2R2D

1.03e-0315582696
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS8 CCN2 FBXL19 BAIAP3 DCBLD2 TSPAN3

1.07e-06179836e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

STK36 KMT2B SPEG HEATR5A ABCA7

9.07e-06150835b6f1fc62d08199fed6156c7cd32f66d9926531b5
ToppCellwk_20-22-Hematologic-Myeloid-GMP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DEFA4 CELSR3 AJM1 SMARCC1 SH3D21

1.48e-05166835d96e88e73a40205f32cebd7e54ca1ff09ee1e7e8
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPP2R2B TM4SF5 CHRDL1 UPRT DCBLD2

1.81e-05173835ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPP2R2B TM4SF5 CHRDL1 UPRT DCBLD2

1.81e-051738353725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

M1AP TM4SF5 SSPOP TSPAN3 TNFRSF4

1.86e-051748357be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

M1AP TM4SF5 SSPOP TSPAN3 TNFRSF4

1.91e-051758351b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCellfacs|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA3 SLC10A1 KMT2B INPP4A MRNIP

1.91e-0517583553e96956019f984decc1c81376ebc88fbf3c4d40
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_large-bowel / Manually curated celltypes from each tissue

TIGD2 PPP2R2D SVIL OBSCN UPRT

2.02e-05177835eb87ea93e36a8f97442ec8515f658ee61932dc0f
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD7 SVIL KCNMA1 CHRDL1 CCN2

2.13e-05179835e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 ZAN OBSCN ADAMTS20 SSPOP

2.43e-051848352cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 ZAN OBSCN ADAMTS20 SSPOP

2.43e-05184835ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 ZAN OBSCN ADAMTS20 SSPOP

2.43e-051848352b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell10x5'-GI_small-bowel-Myeloid_Monocytic-Nonclassical_monocytes|GI_small-bowel / Manually curated celltypes from each tissue

SIGLEC7 SVIL KCNMA1 FZD2 SSPOP

2.56e-05186835a16ecf70271894a842925f232009e2623d16947e
ToppCellT_cells-CTLs|World / Immune cells in Kidney/Urine in Lupus Nephritis

DIP2A PPP2R2B PLEKHF1 PTGER2 CYFIP2

3.37e-051978352de34e20915a247bee75aa40495e23c20bb23e18
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CILP PLEKHF1 KCNMA1 CHRDL1 CCN2

3.53e-05199835edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCellBiopsy_Other_PF-Immune-NK_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

DIP2A PPP2R2B PLEKHF1 PTGER2 CYFIP2

3.62e-05200835418d665b8431697fc9e516258c9fe374257750d9
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DIP2A PPP2R2B PLEKHF1 PTGER2 CYFIP2

3.62e-052008350a6fc7eff94e2f71af9f31a01779aafd2f4a6699
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T|COVID-19_Severe / Disease, condition lineage and cell class

DIP2A PPP2R2B INPP4A PLEKHF1 CYFIP2

3.62e-05200835f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
Diseaseisolated growth hormone deficiency type II (implicated_via_orthology)

CSH1 CSH2 CSHL1

1.98e-075813DOID:0060872 (implicated_via_orthology)
Diseaseisolated growth hormone deficiency (implicated_via_orthology)

CSH1 CSH2 CSHL1

6.92e-077813DOID:0060870 (implicated_via_orthology)
Diseasecongenital hypothyroidism (biomarker_via_orthology)

CSH1 CSH2 CSHL1

7.10e-0614813DOID:0050328 (biomarker_via_orthology)
Diseaseosteoporosis (biomarker_via_orthology)

CSH1 CSH2 CSHL1

2.96e-0522813DOID:11476 (biomarker_via_orthology)
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

CSH1 CSH2 CSHL1 CCN2 EDN1

5.42e-05147815DOID:9352 (biomarker_via_orthology)
Diseasetype 1 diabetes mellitus (implicated_via_orthology)

CSH1 CSH2 CSHL1

1.70e-0439813DOID:9744 (implicated_via_orthology)
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

SMARCC1 SMARCC2

2.65e-049812DOID:0050340 (implicated_via_orthology)
DiseaseCoffin-Siris syndrome (implicated_via_orthology)

SMARCC1 SMARCC2

2.65e-049812DOID:1925 (implicated_via_orthology)
Diseasemembranoproliferative glomerulonephritis (biomarker_via_orthology)

CCN2 EDN1

3.30e-0410812DOID:2920 (biomarker_via_orthology)
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

PPP2R2B PPP2R2D

4.83e-0412812DOID:1441 (implicated_via_orthology)
Diseasepulmonary embolism (biomarker_via_orthology)

CCN2 EDN1

4.83e-0412812DOID:9477 (biomarker_via_orthology)
Diseaseposterior thigh muscle volume

CSH1 CSHL1

7.64e-0415812EFO_0020931
DiseaseInvolutional paraphrenia

IFI44L EDN1

2.14e-0325812C1571983
DiseasePsychosis, Involutional

IFI44L EDN1

2.14e-0325812C1571984
DiseaseInvolutional Depression

IFI44L EDN1

2.14e-0325812C0011574
DiseaseHyalinosis, Segmental Glomerular

CCN2 EDN1

2.69e-0328812C0086432

Protein segments in the cluster

PeptideGeneStartEntry
GMLCACIVLCRRSRD

TSPAN3

226

O60637
RSFICRMRCGSSSVD

ARNT

261

P27540
TIRLCDMRASALCDR

PPP2R2B

246

Q00005
ACRRRAACVLFTVMD

BAIAP3

1091

O94812
MGCIQSITCKARIRR

FAM78B

1

Q5VT40
ALSSSVMCPDARSRC

GRN

201

P28799
DLMTCSNARCRRTET

AJM1

661

C9J069
MAARLVSRCGAVRAA

COQ6

1

Q9Y2Z9
TFLRMVQCRSVEGSC

CSHL1

206

Q14406
TIRLCDMRSSALCDR

PPP2R2D

256

Q66LE6
MEEIRRLCRTSVPCA

ATG4B

176

Q9Y4P1
MERGRLNCSTSCERK

ADAMTS20

1536

P59510
LCSRLAIMVNGRFRC

ABCA7

1991

Q8IZY2
LGPRELCICMRVCRT

FBXL19

436

Q6PCT2
CELLSVNSCMGRVRR

MROH7

846

Q68CQ1
TQALECMRSEGCRRE

INPP4A

926

Q96PE3
CRRSRAASMGRCSVP

PCDHB18P

661

Q96TA0
MASLQRSRVLRCCSC

MRNIP

1

Q6NTE8
MAACTARRALAVGSR

POLDIP2

1

Q9Y2S7
TCISELRMLQREGCF

M1AP

91

Q8TC57
RSERDCSCMSGRVRG

KCNMA1

716

Q12791
TCRDQARMGCRSRAI

FLYWCH1

451

Q4VC44
SIEDMVERCSRQGCT

IFI44L

36

Q53G44
TFLRMVQCRSVEGSC

CSH2

201

P0DML3
ELRDRLCCRMTFGTA

PGM2L1

56

Q6PCE3
MRSVLCCRISLRTQD

PTGER2

326

P43116
RSICERARQGCEALM

FZD2

111

Q14332
AAVARGRQMRCELCL

KMT2B

1631

Q9UMN6
CCGLSMFEVILTRIR

CYFIP2

1111

Q96F07
VSCCRGRLAAVRVMI

KIF25-AS1

126

Q9Y6Z4
VCMEATGCTRRLVVQ

OBSCN

936

Q5VST9
LNGRCRRTVSMETGC

SLC10A1

246

Q14973
NRLRAGLCDRCMVTQ

RBBP8NL

66

Q8NC74
RSLCERARQGCEALM

FZD7

121

O75084
AARSCLTDRSMAVRC

HEATR5A

181

Q86XA9
ISQMCSSRVCRTELE

CHRDL1

426

Q9BU40
ASCRLEKQSRLCMVR

CCN2

226

P29279
MASRAVVRARRCPQC

DCBLD2

1

Q96PD2
NLSCVRTCMVVAEER

DIP2A

1271

Q14689
RCRCSRTGTFGVLMD

CELSR3

2511

Q9NYQ7
TFLRMVQCRSVEGSC

CSH1

201

P0DML2
VSGSTRGMVCSCRLV

DEFA4

56

P12838
RGMVCSCRLVFCRRT

DEFA4

61

P12838
CARLSVRMSSTGIDR

DHRS2

16

Q13268
RLRRSKRCSCSSLMD

EDN1

46

P05305
DICMRCTQTRFSALT

PLEKHF1

156

Q96S99
MACGFRRAIACQLSR

RARS2

1

Q5T160
CIICSATITRRTDML

TRMT1L

186

Q7Z2T5
FMAVSCATCQEIRRT

PPP4R1

276

Q8TF05
SSERCLGEMKCTLVR

SH3D21

426

A4FU49
SVCSEPCRGTMTRQR

SSPOP

1761

A2VEC9
AGMEVVTCANRCPRR

SSPOP

4066

A2VEC9
CHCSSLRSRTSMVVL

SVIL

1901

O95425
TIMTRCIQCTRCIRF

NDUFS1

171

P28331
MLGVRCLLRSVRFCS

NARS2

1

Q96I59
DLQSCMICVARRITT

NCOA3

241

Q9Y6Q9
SRCILQRTMTDVADC

PIWIL4

651

Q7Z3Z4
MLEKRSVGCRRCAVV

ST3GAL1

131

Q11201
CTLSIRDARMSDAGR

SIGLEC7

106

Q9Y286
MQSERCRRVICLVGA

SIRT2

71

Q8IXJ6
VMGVRTCESRCLFSG

VPS8

276

Q8N3P4
CRRNLTGDVCAVMRV

SMARCC1

511

Q92922
CRRNLAGDVCAIMRV

SMARCC2

486

Q8TAQ2
TLRRDSLMCFTVLCE

STK36

581

Q9NRP7
QTRTRICLAEMVSLC

CILP

171

O75339
SCQRCTETRSIVRGR

CILP

481

O75339
MGRRCCRRRVLAAAC

CHST13

1

Q8NET6
ASVGRMLERVIGRCS

ATP11B

1131

Q9Y2G3
TCSVCQETFRRRMEL

ZBTB48

351

P10074
GCRSSRERIIIMCCA

TIGD2

201

Q4W5G0
RERIIIMCCANATGL

TIGD2

206

Q4W5G0
NVEEVCRPRTRMLCS

TULP4

896

Q9NRJ4
CALATEASRRGRMLS

PLEKHA6

996

Q9Y2H5
DSCPVRIRNRCVMTS

MRPS14

81

O60783
LCVVMESIRTTRQCS

PJVK

156

Q0ZLH3
ICRVSRRDMGALTCT

SPEG

1451

Q15772
RCEVSTRFDMGSLRR

TRAF6

496

Q9Y4K3
DLLSRLSRCCIMGRL

TEX10

631

Q9NXF1
QCSGCRGTVRIEMFR

STAG1

126

Q8WVM7
GMVSRCSRSQNTVCR

TNFRSF4

51

P43489
CLREMSRVCTPTTGR

THUMPD3

426

Q9BV44
TMRCRAEELREGTLC

ZSWIM8

901

A7E2V4
CGNRCRMLRSVFSSA

TM4SF5

81

O14894
MEQGLRDCCRSIRIG

UPRT

191

Q96BW1
MCCTEGSLRKRDSQR

WDR36

1

Q8NI36
SIRRGSCNRVCMMQT

ZAN

196

Q9Y493
VLMCRDPSRSRLCSI

VN1R2

366

Q8NFZ6