Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of DNA catabolic process

ATM AIFM1 APAF1

8.27e-0618463GO:1903624
GeneOntologyBiologicalProcessDNA catabolic process

ATM AIFM1 APAF1

7.65e-0537463GO:0006308
GeneOntologyBiologicalProcesspositive regulation of epithelial cell migration

DOCK5 CCR6 GFUS ENPP2 ADAM9

8.48e-05202465GO:0010634
DomainDUF3338

FRMD4A FRMD4B

3.40e-054452PF11819
DomainDUF3338

FRMD4A FRMD4B

3.40e-054452IPR021774
DomainEz/rad/moesin-like

FRMD4A FRMD4B

1.16e-0321452IPR000798
DomainFERM_CS

FRMD4A FRMD4B

1.51e-0324452IPR019747
DomainFERM_C

FRMD4A FRMD4B

1.78e-0326452PF09380
DomainFERM_C

FRMD4A FRMD4B

1.92e-0327452SM01196
DomainFERM_PH-like_C

FRMD4A FRMD4B

1.92e-0327452IPR018980
Domain-

FRMD4A DOK2 ELMO3 PLEKHG7 FRMD4B

2.41e-033914552.30.29.30
DomainFERM_N

FRMD4A FRMD4B

2.86e-0333452PF09379
DomainFERM_N

FRMD4A FRMD4B

2.86e-0333452IPR018979
DomainPH_dom-like

FRMD4A DOK2 ELMO3 PLEKHG7 FRMD4B

3.48e-03426455IPR011993
DomainFERM_M

FRMD4A FRMD4B

5.49e-0346452PF00373
Domain-

FRMD4A FRMD4B

6.21e-03494521.20.80.10
DomainFERM_central

FRMD4A FRMD4B

6.21e-0349452IPR019748
DomainFERM_domain

FRMD4A FRMD4B

6.21e-0349452IPR000299
DomainFERM_1

FRMD4A FRMD4B

6.46e-0350452PS00660
DomainFERM_2

FRMD4A FRMD4B

6.46e-0350452PS00661
DomainFERM_3

FRMD4A FRMD4B

6.46e-0350452PS50057
DomainBand_41_domain

FRMD4A FRMD4B

6.46e-0350452IPR019749
DomainB41

FRMD4A FRMD4B

6.46e-0350452SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

FRMD4A FRMD4B

6.46e-0350452IPR014352
Domain-

FMO4 AIFM1

8.05e-03564523.50.50.60
DomainFAD/NAD-binding_dom

FMO4 AIFM1

8.33e-0357452IPR023753
DomainUSP_CS

USP32 USP29

1.10e-0266452IPR018200
Pubmed

ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?

ATM ENPP2

1.71e-06246228968864
Pubmed

Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells.

AIFM1 APAF1

5.13e-06346228627586
Pubmed

B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging.

CCR6 AICDA

5.13e-06346231492809
Pubmed

HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice.

AIFM1 APAF1

5.13e-06346218497877
Pubmed

ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.

ATM AICDA

5.13e-06346226400962
Pubmed

mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM.

ATM AIFM1

5.13e-06346227197168
Pubmed

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.

AIFM1 APAF1

1.03e-05446211279485
Pubmed

Type I Interferons Function as Autocrine and Paracrine Factors to Induce Autotaxin in Response to TLR Activation.

TLR9 ENPP2

1.03e-05446226313906
Pubmed

Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.

AIFM1 APAF1

1.03e-05446215703386
Pubmed

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.

AIFM1 APAF1

1.03e-05446216917506
Pubmed

Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development.

OCA2 ATM

1.03e-05446214500365
Pubmed

AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.

ATM AICDA

1.03e-05446220864035
Pubmed

Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response.

ATM AICDA

1.71e-05546226822034
Pubmed

TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone.

CCR6 AICDA

1.71e-05546231506281
Pubmed

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.

ATM AICDA

1.71e-05546218316419
Pubmed

Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.

AIFM1 APAF1

1.71e-05546218256270
Pubmed

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

ATM AICDA

1.71e-05546217599403
Pubmed

Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus.

TLR9 AICDA

1.71e-05546224500834
Pubmed

Acetate differentially regulates IgA reactivity to commensal bacteria.

CCR6 AICDA

2.56e-05646234262176
Pubmed

A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.

ATM AICDA

2.56e-05646224097111
Pubmed

The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production.

TLR9 ERN1

2.56e-05646226173697
Pubmed

Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF.

AIFM1 APAF1

2.56e-05646217603079
Pubmed

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus.

TLR9 AICDA

2.56e-05646227035940
Pubmed

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

ATM AICDA

3.58e-05746226308889
Pubmed

Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis.

AIFM1 APAF1

3.58e-05746215271982
Pubmed

Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism.

CCR6 AICDA

4.77e-05846235768001
Pubmed

Role of the translocation partner in protection against AID-dependent chromosomal translocations.

ATM AICDA

4.77e-05846219966290
Pubmed

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.

FRMD4A FRMD4B

4.77e-05846220080746
Pubmed

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.

ATM TLR9

6.12e-05946216413926
Pubmed

Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice.

AIFM1 APAF1

6.12e-05946221221781
Pubmed

Resurrection of endogenous retroviruses in antibody-deficient mice.

TLR9 AICDA

6.12e-05946223103862
Pubmed

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.

ATM AICDA

7.65e-051046227320916
Pubmed

Molecular components of a cell death pathway activated by endoplasmic reticulum stress.

AIFM1 APAF1

9.34e-051146214561754
Pubmed

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

ATM AICDA

9.34e-051146216400328
Pubmed

The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.

DOCK5 ELMO3

1.32e-041346221930703
Pubmed

Sexual differences of imprinted genes' expression levels.

MEST USP29

2.03e-041646224125951
Pubmed

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

EXOC1 AIFM1 IQGAP3

2.12e-048746333711283
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TNIK OGA SIPA1L1 APAF1

2.25e-0422546412168954
Pubmed

Phosphoproteomic analysis of the developing mouse brain.

TNIK FRMD4A GCFC2 OGA

3.16e-0424646415345747
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

MEST FRMD4A GFUS CPLANE1 AIFM1 SIPA1L1

3.90e-0473246634732716
Pubmed

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.

ERN1 AIFM1

4.64e-042446219139267
Pubmed

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.

CCR6 ENPP2 TIPARP

5.33e-0411946324162774
Pubmed

No death without life: vital functions of apoptotic effectors.

AIFM1 APAF1

5.45e-042646218309324
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

TNIK DOCK5 FRMD4A ADAM9 USP32

9.08e-0456946530639242
Pubmed

Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.

ATM APAF1

9.35e-043446212549820
Pubmed

Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase.

MPC2 CEP295NL

9.90e-043546221779533
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

TNIK FRMD4A EXOC1

1.06e-0315146317043677
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMD4A FRMD4B

1.99e-03502421293
GeneFamilyUbiquitin specific peptidases

USP32 USP29

2.49e-0356242366
CoexpressionGSE29618_BCELL_VS_PDC_DAY7_FLU_VACCINE_UP

CCR6 ATM OGA MARCHF8 SIPA1L1

2.26e-05194465M4958
CoexpressionGSE25087_TREG_VS_TCONV_ADULT_UP

CCR6 DOK2 FRMD4B IQGAP3 TIPARP

2.55e-05199465M4650
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK CCR6 OGA TIPARP

2.65e-0516746483969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCR6 TLR9 AICDA PLEKHG7

2.84e-05170464ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCR6 TLR9 AICDA PLEKHG7

2.84e-05170464d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCellBAL-Mild-Lymphocyte-B-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCR6 TLR9 AICDA PLEKHG7

2.84e-0517046452787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK CCR6 ERN1 FRMD4B

2.84e-05170464adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

MEST FRMD4A OGA VKORC1L1

3.32e-05177464f0edf04930692418953e4f00a917257804ec0ffd
ToppCellRV-11._Adipocyte|RV / Chamber and Cluster_Paper

MEST FRMD4A OGA VKORC1L1

3.39e-05178464278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCellRA-11._Adipocyte|RA / Chamber and Cluster_Paper

MEST FRMD4A OGA VKORC1L1

3.55e-05180464d48a3d27357f7d184132a6805950f93080146b59
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 PLEKHG7 FRMD4B ENPP2

3.62e-05181464a8e9ea73c24109a5d4d28bc0577cc869ad932a4d
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

MEST FRMD4A OGA VKORC1L1

3.78e-05183464b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

MEST FRMD4A OGA VKORC1L1

3.78e-051834643f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T|lymph-node_spleen / Manually curated celltypes from each tissue

DOCK5 MEST DCUN1D1 ADAM9

4.03e-0518646417eec1efad1f5e9ced1eb6bc9eb5dd7ded789c61
ToppCellRA-11._Adipocyte|World / Chamber and Cluster_Paper

MEST FRMD4A OGA VKORC1L1

4.20e-051884644dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

DOCK5 CCR6 ERN1 TIPARP

4.38e-051904640c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 FMO4 FRMD4B ENPP2

4.38e-05190464396b7225c2430db3dc55a3d0db70239b71987229
ToppCellCTRL-Myeloid-Alveolar_Macrophage|Myeloid / Disease state, Lineage and Cell class

TNIK FRMD4A ANO5 DOK2

4.65e-0519346480871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK5 FRMD4A FRMD4B ENPP2

4.75e-05194464b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_2-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK5 CCR6 CEP295NL APAF1

4.84e-051954647606b8b40e704bb5447ac57ccf8698794e9c7890
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK5 FRMD4A FRMD4B ENPP2

4.84e-051954640e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Trm_Th1/Th17|lymph-node_spleen / Manually curated celltypes from each tissue

CCR6 ERN1 FRMD4B TIPARP

4.84e-05195464c60982804a74dbe6607c021799ca74af2204aba8
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TNIK MEST FRMD4B ENPP2

4.94e-051964641450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellmLN-T_cell-Th17|mLN / Region, Cell class and subclass

CCR6 DOK2 ERN1 MUC17

5.14e-0519846404905f62941b193864704a10ad692faf777fa51d
ToppCellmLN-(1)_T_cell-(13)_Th17|mLN / shred on region, Cell_type, and subtype

CCR6 DOK2 ERN1 MUC17

5.14e-05198464c575e9aeee4e034e8c4d171fe754403652343731
ToppCell10x5'v1-week_14-16-Hematopoietic|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MPC2 DCUN1D1 GFUS MARCHF8

5.24e-05199464c555d88b66939e7dff2cb44d1f8feb53fbd8bd82
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TNIK CCR6 ERN1 TIPARP

5.24e-05199464cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell10x5'v1-week_14-16-Hematopoietic-erythroid-mid_erythroid|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FRMD4A DCUN1D1 GFUS MARCHF8

5.24e-05199464e6853b2c0ef6549d5554754c5d5f65825b66025b
ToppCell10x5'v1-week_14-16-Hematopoietic-erythroid|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MPC2 DCUN1D1 GFUS MARCHF8

5.24e-051994648d0eb13a391a2ac1b4f332290c2d00a7fb42bddc
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

FRMD4A ATM ERN1

2.78e-04123463511b7c20a4a85e49980936d52af7dbca19bb848e
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MEST ELMO3 FMO4

4.50e-04145463186b8bd8ac2d5c66cc29fdc2dd6751eddce3e8b8
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-Trm_Th1/Th17|bone_marrow / Manually curated celltypes from each tissue

CCR6 ERN1 FRMD4B

4.87e-04149463264fe2ceac6379b3394d2bb47ef34692e4a64559
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TNIK TRIT1 ATM

5.46e-04155463b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

FRMD4A FRMD4B ENPP2

5.56e-041564639a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TNIK OCA2 ENPP2

5.67e-04157463f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK5 OCA2 ENPP2

5.67e-041574631e3a4a7193d95f09d71c2dfe704b8e626c6d9624
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TNIK OCA2 ENPP2

5.67e-0415746343a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Glra3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO5 FRMD4B USP29

5.99e-041604630bfdaf979e6f128cba2928ce16bca4d3deff8ac9
ToppCellfacs-Skin-Anagen-3m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 ENPP2 USP29

6.10e-041614638d2987271da52fd8353557ac6faa4f7a4be0ed2a
ToppCellMild-MAIT|Mild / Disease group and Cell class

CCR6 ERN1 AICDA

6.10e-041614630c1a04485708d5302600cdc2d7dac1cb76b4033a
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK DOK2 IQGAP3

6.32e-04163463453e0bb292baca2938d24582fedfd6a8bb1e78e9
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-Trm_Th1/Th17|bone_marrow / Manually curated celltypes from each tissue

CCR6 ERN1 FRMD4B

6.32e-041634634d1fd0b1246833723b938eca0cb246e937380e12
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK CCR6 ERN1

6.43e-041644638f3255d7f67890389a768453492243ea982eb38a
ToppCellMild-MAIT|World / Disease group and Cell class

CCR6 ERN1 AICDA

6.43e-0416446321dc02997dfae73cf70ce291661928526605dba1
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR6 ATM ERN1

6.43e-0416446374bf6080abd9191e3db8ee892fce84f1dcc4b775
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR6 ATM ERN1

6.66e-041664639fae71b0a42a9b2222453c03e0a1e83f30117ae9
ToppCellnormal_Lung-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

FRMD4B TIPARP APAF1

6.66e-0416646307b498eb341abec02a3ccaae320bdbb5cd6883c5
ToppCellLV-11._Adipocyte|World / Chamber and Cluster_Paper

MEST ENPP2 VKORC1L1

6.66e-041664637e5852891714465c6228c9f955fd511ec79d0e02
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR9 ERN1 ENPP2

7.14e-0417046392e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR9 ERN1 ENPP2

7.14e-041704639f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR9 ERN1 ENPP2

7.14e-04170463b49f7c8a27078de2137ed04f74cfee30729cfa5e
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRIT1 CCR6 ELMO3

7.14e-04170463070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell5'-Adult-LargeIntestine-Hematopoietic-T_cells-ILC3|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR6 ERN1 TIPARP

7.26e-041714636ab7f103cbdbd49ef687cbb8a42ddc5517af0f7f
ToppCell10x5'-Liver-Lymphocytic_B-ABC_aged-B_memory|Liver / Manually curated celltypes from each tissue

TLR9 AICDA PLEKHG7

7.26e-04171463eb47f4a09a630ed14a0898377039ed50ef7cc292
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK CCR6 DOK2

7.26e-04171463246fc7edcefc47437d1df6029f295aca3b34b2b2
ToppCell368C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

GCFC2 ERN1 PEX26

7.26e-04171463f3bf5805823d5733b58742172e7668725ce82931
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK CCR6 DOK2

7.26e-041714631fb4e11f92b48dc2d6e553c22e2571bbd8c223c6
ToppCellCD8+_Memory_T_cell-FLU-3|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

LINS1 CCR6 ADAM9

7.39e-0417246345ac433dbb3796f69e886c04457b2971403050ee
ToppCellfacs-Trachea-nan-24m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR6 AICDA SIPA1L1

7.51e-0417346371c90c57225e452c73bf7bea46b454c472bf5f76
ToppCellLV-11._Adipocyte|LV / Chamber and Cluster_Paper

MEST ENPP2 VKORC1L1

7.51e-04173463c2d3fcb3de71015d03d14c63450853d2b03ffa71
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK DOK2 ERN1

7.64e-04174463a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK DOK2 ERN1

7.64e-041744637f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCR6 AICDA PLEKHG7

7.76e-041754631b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ERN1 USP32 APAF1

7.76e-04175463334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FRMD4A ELMO3 FRMD4B

7.76e-041754636374ab186d7ccf7f6dfb858267edba8962789e15
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ERN1 USP32 APAF1

7.76e-04175463da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPC2 CCR6 TIPARP

7.76e-041754635f5fc1bf29f07e086951d4f9486b5f07bdcc5d4f
ToppCellfacs-MAT-Fat-3m-Lymphocytic-T_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOK2 ERN1 FRMD4B

7.89e-0417646371b3309ddadd035a1224fca4fc5946dc4c0283fe
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CCR6 ATM ERN1

7.89e-04176463003076f1a983409ddf31b9c19e61c1facdd72566
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-T_mait-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CCR6 ERN1 TIPARP

8.02e-04177463605f71515c877bb4de4121675ec8c1318a2500a7
ToppCellCOVID-19_Severe-MAIT|COVID-19_Severe / Disease condition and Cell class

CCR6 ERN1 TIPARP

8.02e-041774638eb69041f482b58325e3539f607923f7b1fa5977
ToppCellSevere-CD4+_T_activated|Severe / Disease group and Cell class

CCR6 PLEKHG7 FRMD4B

8.02e-04177463a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCellIIF-Lymphocyte-T_NK-MAIT|IIF / Disease, Lineage and Cell Type

CCR6 ERN1 TIPARP

8.16e-04178463be777ebef8f09a1a16fcee8fc69a65ab295b6e1d
ToppCellChildren_(3_yrs)|World / Lineage, Cell type, age group and donor

TNIK DOK2 TIPARP

8.16e-04178463df2ecd3214590b914f2762db57efe780ba038db3
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th17|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR6 DOK2 ERN1

8.29e-0417946361472d75f4a3c4374eeb55ef79982ae4054dadaa
ToppCellBAL-Severe-Lymphocyte-B-B_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCR6 MARCHF8 APAF1

8.42e-04180463c3c72531af5b9f7a7416727fe609dab5180e03b6
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell-B_activate-7|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCR6 MARCHF8 APAF1

8.42e-041804639f4bbaf6435c23e3e552ae22be8ea7884314192d
ToppCellSevere-Lymphoid-B-|Severe / Condition, Lineage, Cell class and cell subclass

CCR6 TLR9 AICDA

8.42e-04180463fd3eb751704b14ff1500e4bd041441644d233e9c
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCR6 MARCHF8 APAF1

8.42e-04180463b465f2f8b0e9a2034a4f1272bb00c77439164dbf
ToppCellSevere-Lymphoid-B|Severe / Condition, Lineage, Cell class and cell subclass

CCR6 TLR9 AICDA

8.42e-0418046367ffaf5096f025c3c61fffe52f6c8a96f120fc6f
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CCR6 TLR9 AICDA

8.56e-04181463700adfb41e4e377530f0dd31be89e12f109f3469
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 FRMD4B ENPP2

8.70e-04182463d524ad5cf00f05ee27c9db2ffa2d4e30a1e2e21a
ToppCellIPF-Myeloid-DC_Langerhans|World / Disease state, Lineage and Cell class

DOCK5 CCR6 ENPP2

8.70e-041824630e8cfbd8ea196f27a227dbb4d2eb93bc48d27922
ToppCellPND10-Immune-Immune_Myeloid-Dendritic-cDC1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COG5 IQGAP3 ADAM9

8.84e-04183463ab38264daddccdf5ffb75ff2210b27423eca6bc0
ToppCellPND10-Immune-Immune_Myeloid-Dendritic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COG5 IQGAP3 ADAM9

8.84e-04183463e4911601dca2c0ecb448cdb6b222dedfc0c8bf6c
ToppCellSevere_COVID-19-B_cell-B_cell|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

CCR6 TLR9 AICDA

8.84e-041834635634e528001c389efd1e380f01ad40072f60e943
ToppCellHSPCs-Ery/Mk_prog.|HSPCs / Lineage and Cell class

TNIK DOK2 SIPA1L1

8.84e-0418346359cfb02143b6b54dfca7560562e064948f0340ca
ToppCellMild-Lymphoid-B|Mild / Condition, Lineage, Cell class and cell subclass

CCR6 TLR9 AICDA

8.84e-041834639b64d2d143525e6f48a191facfd101462ff36324
ToppCellPND10-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COG5 IQGAP3 ADAM9

8.84e-04183463263bfa1d8a7314bc3156c735c403c3bab8ea4dac
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 FRMD4B ENPP2

8.84e-041834635472cdce6d99314d229418412acf1fff6340db7d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 FRMD4B ENPP2

8.84e-0418346393213124e55d1b673dd345188caf8b5bd31d99fe
ToppCellMild_COVID-19-B_cell|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

CCR6 TLR9 AICDA

8.84e-04183463dea119e2988e954475f557f0bbe12556a83e81a4
ToppCellNS-critical-d_0-4-Lymphoid-Treg|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCR6 ATM ERN1

8.84e-04183463f478dfa231fc1b12ead0183cc9d22077cdf43d1f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK MPC2 ERN1

8.84e-04183463317b756378a9efd8ecb754acf7273f83f996e106
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK LINS1 ATM

8.84e-04183463f2ef110bf29b1a8276ef216238363e542db262c1
ToppCellMild-Lymphoid-B-|Mild / Condition, Lineage, Cell class and cell subclass

CCR6 TLR9 AICDA

8.84e-04183463b5740f05a4dcdbbf24f7bf7a3f57ac01a5e75f60
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 FRMD4B ENPP2

8.98e-04184463f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CCR6 TLR9 AICDA

8.98e-041844633f8a359e40bebe58545f708682e5e5d1b70cf5cb
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 FRMD4B ENPP2

8.98e-041844635939527d24d299e562e707469c9123890edd76be
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CCR6 TLR9 AICDA

8.98e-0418446364bede8db709fd32f40c03265b96f0b12155bb8a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK LINS1 ATM

8.98e-041844635350b58aa9979631228835d11eb45ddf81d08bff
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 FRMD4B ENPP2

8.98e-04184463a2191dd5546efd357b23e625beb3c5820476f243
DiseaseRetinal Pigment Epithelial Detachment

AIFM1 APAF1

8.50e-059462C0339546
DiseaseRetinal Detachment

AIFM1 APAF1

1.30e-0411462C0035305
Diseaseresponse to benznidazole

OCA2 FRMD4B

4.44e-0420462EFO_0600031
Diseasecarnosine measurement

FRMD4A COG5

6.42e-0424462EFO_0010470
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

TNIK GCFC2 SIPA1L1

6.81e-04110463EFO_0803335
Diseaseglutamate measurement

COG5 TAF1L

9.40e-0429462EFO_0010487
Diseasehuman immunodeficiency virus infectious disease (is_marker_for)

ATM AICDA

1.45e-0336462DOID:526 (is_marker_for)
DiseaseCombined oxidative phosphorylation deficiency

TRIT1 AIFM1

1.53e-0337462cv:C4540031
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

ATM ERN1 APAF1

1.60e-03148463C0279702

Protein segments in the cluster

PeptideGeneStartEntry
RADAKLWKNYQLQRL

CEP295NL

96

Q96MC4
NRWEYYLKQLQNKQF

APAF1

336

O14727
LFLEFWKQRQARLEY

ANO5

396

Q75V66
LRFKQWNGKERSIYF

AIFM1

191

O95831
FLYQFKNVRWAKGRR

AICDA

11

Q9GZX7
QKFRNYFLKILKDLW

CCR6

321

P51684
FQEKRQWLLKYQSLL

DMXL1

2116

Q9Y485
LNGRFKFLDLWNKFL

DCUN1D1

186

Q96GG9
LLRLLYWNRKLYNKE

OCA2

526

Q04671
LRVQNQFLWEKYKRK

TIPARP

496

Q7Z3E1
LFRIWRYNQELKAKA

MPC2

111

O95563
YARKQNRWVKNRFLS

TRIT1

321

Q9H3H1
LYLQQQQTFGKKWRR

DOK2

11

O60496
RYLKLLQKDWDNFFT

LINS1

526

Q8NG48
YKLAQLFRWIRKAAF

PEX26

281

Q7Z412
FLNWIQERKLNKRFN

FMO4

251

P31512
RVWFQNRRVKYQKQQ

NOTO

201

A8MTQ0
WKRLKAYNRVIYVQN

MARCHF8

226

Q5T0T0
LFRNIKYNLDFWRKN

GFUS

76

Q13630
QRKIYLEWLQYFKAN

IQGAP3

776

Q86VI3
LLRLYNDLWKRLQQY

COG5

416

Q9UP83
PRKIFQWRQLENLYF

FRMD4A

251

Q9P2Q2
QWRQLENLYFREKKF

FRMD4A

256

Q9P2Q2
RKLFQWKQLENLYFR

FRMD4B

291

Q9Y2L6
NWDAVFRFLQKYIQK

ATM

56

Q13315
IWRKLYVNNKLTLFR

DOCK5

101

Q9H7D0
ILYKKTLWYQAQLNR

CPLANE1

771

Q9H799
KFQERQFWSGLKLFR

GCFC2

641

P16383
LKSKNKLNYLRNYWL

ERN1

346

O75460
IFIKRDQLWRSYFRK

ADAM9

716

Q13443
LDYLWQRNLRQFIYK

ELMO3

251

Q96BJ8
WKLNQRYLRKKIDFV

EXOC1

116

Q9NV70
LLQYINQRKKFRRRW

MEST

251

Q5EB52
RVWNYFQRVLVKKYA

ENPP2

711

Q13822
KRQKYRLSQLYKWQE

MUC17

4421

Q685J3
FARKLLLNWVYNTRK

SLC9C1

576

Q4G0N8
LFRRLQKWELNTYLY

OGA

81

O60502
LQVFIYRLFWKSKDR

TAF1L

826

Q8IZX4
WNNLLRKRNFYKKLE

SERPINA4

301

P29622
YEFKFPFRNNNKWQR

SIPA1L1

1056

O43166
RKRSRKELLNFYAWQ

RRP7A

231

Q9Y3A4
KKNKLRVYYLSWLRN

TNIK

1106

Q9UKE5
QVLRLRDNYLAFFKW

TLR9

656

Q9NR96
LKRYSFNNAWLLVKN

USP29

511

Q9HBJ7
NYKRLVYLNEAWKRQ

VKORC1L1

156

Q8N0U8
KVKWLDNFQKFRYLQ

PLEKHG7

481

Q6ZR37
VNYEKFRNWLFLNKD

USP32

141

Q8NFA0