Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessSchwann cell differentiation

GPC1 NAB2 CNTNAP1 PRX DHH

3.55e-05551405GO:0014037
GeneOntologyBiologicalProcesspeptidyl-lysine trimethylation

FAM86B1 FAM86B2 EEF2KMT

4.85e-05111403GO:0018023
GeneOntologyBiologicalProcesspeptidyl-lysine methylation

FAM86B1 FAM86B2 EEF2KMT EHMT2

4.86e-05301404GO:0018022
GeneOntologyCellularComponentVCP-NPL4-UFD1 AAA ATPase complex

FAF1 FAF2 UBXN7 VCP

1.28e-0781394GO:0034098
DomainUAS

FAF1 FAF2 UBXN7

3.69e-0731353SM00594
DomainUAS

FAF1 FAF2 UBXN7

3.69e-0731353IPR006577
DomainFAM86

FAM86B1 FAM86B2 EEF2KMT

1.47e-0641353IPR029426
DomainFAM86

FAM86B1 FAM86B2 EEF2KMT

1.47e-0641353PF14904
DomainRBM39_linker

RBM23 RBM39

5.19e-0521352IPR029123
DomainCDC48_N

NSF VCP

5.19e-0521352PF02359
DomainCDC48_N

NSF VCP

5.19e-0521352SM01073
DomainCDC48_2

NSF VCP

5.19e-0521352SM01072
DomainRBM39_SF

RBM23 RBM39

5.19e-0521352IPR006509
DomainCDC48_2

NSF VCP

5.19e-0521352PF02933
DomainRBM39linker

RBM23 RBM39

5.19e-0521352PF15519
DomainCdc48_dom2

NSF VCP

5.19e-0521352IPR004201
DomainCDC4_N-term_subdom

NSF VCP

5.19e-0521352IPR003338
DomainMethyltransf_16

FAM86B1 FAM86B2 EEF2KMT

5.84e-05111353IPR019410
DomainMethyltransf_16

FAM86B1 FAM86B2 EEF2KMT

5.84e-05111353PF10294
DomainUBX_dom

FAF1 FAF2 UBXN7

1.00e-04131353IPR001012
DomainUBX

FAF1 FAF2 UBXN7

1.00e-04131353PF00789
DomainUBX

FAF1 FAF2 UBXN7

1.00e-04131353PS50033
DomainRasGAP

RASA1 RASA4 RASA4B

1.27e-04141353SM00323
DomainRasGAP_CS

RASA1 RASA4 RASA4B

1.27e-04141353IPR023152
DomainCDC48_domain_2-like

NSF VCP

1.55e-0431352IPR029067
Domain-

RASA4 RASA4B

1.55e-04313524.10.1130.10
Domain-

NSF VCP

1.55e-04313523.10.330.10
DomainRasGAP

RASA1 RASA4 RASA4B

1.58e-04151353PF00616
DomainRAS_GTPASE_ACTIV_1

RASA1 RASA4 RASA4B

1.58e-04151353PS00509
DomainRAS_GTPASE_ACTIV_2

RASA1 RASA4 RASA4B

1.58e-04151353PS50018
Domain-

RASA1 RASA4 RASA4B

1.93e-041613531.10.506.10
DomainIG_LIKE

FLT4 SPEG HLA-DRB3 BCAN ISLR SEMA3G BTN2A1 CD7 PXDNL MYOM2 FCRL5 TREML1

2.36e-0449113512PS50835
DomainRasGAP_dom

RASA1 RASA4 RASA4B

2.78e-04181353IPR001936
DomainIg-like_dom

FLT4 SPEG HLA-DRB3 BCAN ISLR SEMA3G BTN2A1 CD7 PXDNL MYOM2 FCRL5 TREML1

2.94e-0450313512IPR007110
DomainEGF_3

CNTNAP1 CRTAC1 BCAN SSPOP SNED1 FBLN1 NTNG2 PROS1

3.13e-042351358PS50026
Domain-

FLT4 SPEG HLA-DRB3 BCAN ISLR SEMA3G PLXND1 BTN2A1 SNED1 CD7 PXDNL MYOM2 FCRL5 TREML1

3.20e-04663135142.60.40.10
DomainThioredoxin-like_fold

CLIC3 MRPL43 FAF1 FAF2 UBXN7 PRXL2C

3.97e-041321356IPR012336
DomainAsp_de-COase-like_dom

NSF VCP

5.11e-0451352IPR009010
DomainEGF_1

CNTNAP1 CRTAC1 BCAN SSPOP SNED1 FBLN1 NTNG2 PROS1

5.39e-042551358PS00022
DomainIg-like_fold

FLT4 SPEG HLA-DRB3 BCAN ISLR SEMA3G PLXND1 BTN2A1 SNED1 CD7 PXDNL MYOM2 FCRL5 TREML1

5.99e-0470613514IPR013783
DomainEGF_2

CNTNAP1 CRTAC1 BCAN SSPOP SNED1 FBLN1 NTNG2 PROS1

6.94e-042651358PS01186
DomainIG

FLT4 SPEG BCAN SEMA3G BTN2A1 CD7 PXDNL MYOM2 FCRL5 TREML1

9.81e-0442113510SM00409
DomainIg_sub

FLT4 SPEG BCAN SEMA3G BTN2A1 CD7 PXDNL MYOM2 FCRL5 TREML1

9.81e-0442113510IPR003599
DomainBTK

RASA4 RASA4B

1.81e-0391352SM00107
DomainZnf_Btk_motif

RASA4 RASA4B

1.81e-0391352IPR001562
DomainBTK

RASA4 RASA4B

1.81e-0391352PF00779
DomainZF_BTK

RASA4 RASA4B

1.81e-0391352PS51113
Domain-

RASA1 FRS3 FRS2 ARHGEF25 MTMR10 ARHGEF39 RASA4 SPRED1 RASA4B

2.17e-0339113592.30.29.30
DomainEGF

CNTNAP1 BCAN SNED1 NTNG2 PROS1

2.22e-031261355PF00008
DomainEGF-like_dom

CNTNAP1 CRTAC1 BCAN SNED1 FBLN1 NTNG2 PROS1

2.24e-032491357IPR000742
DomainPTBI

FRS3 FRS2

2.73e-03111352SM00310
DomainEGF-like_CS

CNTNAP1 CRTAC1 BCAN SNED1 FBLN1 NTNG2 PROS1

2.92e-032611357IPR013032
DomainIRS_PTB

FRS3 FRS2

3.26e-03121352PS51064
DomainUBX

FAF1 UBXN7

3.26e-03121352SM00166
DomainRho_GTPase_activation_prot

RASA1 PLXND1 RASA4 RASA4B

3.81e-03881354IPR008936
DomainPH_dom-like

RASA1 FRS3 FRS2 ARHGEF25 MTMR10 ARHGEF39 RASA4 SPRED1 RASA4B

3.83e-034261359IPR011993
DomainAAA

NSF RFC4 HELZ2 VCP DNAH11

3.95e-031441355SM00382
DomainAAA+_ATPase

NSF RFC4 HELZ2 VCP DNAH11

3.95e-031441355IPR003593
DomainIRS

FRS3 FRS2

4.46e-03141352PF02174
DomainIRS_PTB

FRS3 FRS2

4.46e-03141352IPR002404
DomainLDLRA_1

SSPOP MAMDC4 PKD1

5.04e-03481353PS01209
DomainLDLRA_2

SSPOP MAMDC4 PKD1

5.34e-03491353PS50068
DomainEGF_Ca-bd_CS

CRTAC1 SNED1 FBLN1 PROS1

5.39e-03971354IPR018097
DomainEGF_CA

CRTAC1 SNED1 FBLN1 PROS1

5.79e-03991354PS01187
DomainAAA

NSF RFC4 VCP

6.30e-03521353PF00004
DomainATPase_AAA_core

NSF RFC4 VCP

7.00e-03541353IPR003959
PathwayREACTOME_PROTEIN_METHYLATION

FAM86B1 FAM86B2 EEF2KMT VCP

1.52e-0522994MM15519
Pubmed

Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.

DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

3.88e-1712146810433963
Pubmed

Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.

DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

1.00e-1613146817668377
Pubmed

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

1.58e-168146717588759
Pubmed

Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.

DUX4L2 DUX4 DUX1 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

1.87e-1517146811245978
Pubmed

DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

2.36e-1510146717984056
Pubmed

Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

3.34e-141314677739628
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TRPM4 SHROOM3 RHBDF1 SPEG HECTD4 PER1 APEH PFAS PLXND1 ZBTB42 EIF4ENIF1 PSME4 PKD1 HELZ2 SNX15 TNFAIP3 CHPF ESPL1 EVI5L

2.11e-0711051461935748872
Pubmed

Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.

DUX4L9 DUX4L2 DUX4L4

2.89e-074146317911620
Pubmed

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.

RASA1 RASA4 RASA4B

2.89e-074146321460216
Pubmed

The homeobox transcription factor DUXBL controls exit from totipotency.

DUX4L9 DUX4L2 DUX4L4

2.89e-074146338509386
Pubmed

Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.

DUX4L9 DUX4L2 DUX4L4

7.20e-075146320063414
Pubmed

FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis.

FAM86B1 FAM86B2 EEF2KMT

7.20e-075146338508183
Pubmed

Exploring the role of p97 and its UBX-domain cofactors through identification of their interacting proteins.

FAF1 FAF2 VCP

1.44e-066146322350894
Pubmed

Hierarchical binding of cofactors to the AAA ATPase p97.

FAF1 UBXN7 VCP

1.44e-066146321645854
Pubmed

The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.

DUX4L9 DUX4L2 DUX4L4

2.51e-067146330765463
Pubmed

Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect.

NSF FAF2 VCP

4.00e-068146325078495
Pubmed

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.

FAF1 FAF2 UBR5 UBXN7 VCP

6.50e-0662146518775313
Pubmed

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

FAF2 UBXN7 VCP

1.55e-0512146322466964
Pubmed

Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase.

UBXN7 VCP

1.75e-052146228274878
Pubmed

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

RASA4 RASA4B

1.75e-052146211448776
Pubmed

FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.

FRS3 FRS2

1.75e-052146215094036
Pubmed

Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras.

FRS3 FRS2

1.75e-05214628761293
Pubmed

Activation of dopamine D2 receptors in the medial shell region of the nucleus accumbens increases Per1 expression to enhance alcohol consumption.

DRD2 PER1

1.75e-052146235032086
Pubmed

Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells.

FRS2 PKD1

1.75e-052146228077787
Pubmed

Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.

DUX4L9 DUX4

1.75e-052146224145033
Pubmed

Crystallization and preliminary X-ray crystallographic analysis of the N domain of p97/VCP in complex with the UBX domain of FAF1.

FAF1 VCP

1.75e-052146220057067
Pubmed

The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.

FRS3 FRS2

1.75e-052146212586769
Pubmed

Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation.

FRS3 FRS2

1.75e-052146217086210
Pubmed

Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.

FRS3 FRS2

1.75e-052146229155277
Pubmed

Crystallization and preliminary X-ray crystallographic analysis of the hexameric human p97/VCP ND1 fragment in complex with the UBX domain of human FAF1.

FAF1 VCP

1.75e-052146222102026
Pubmed

An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.

RASA4 RASA4B

1.75e-052146216041389
Pubmed

Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes.

FRS3 FRS2

1.75e-052146212688531
Pubmed

The p97-FAF1 protein complex reveals a common mode of p97 adaptor binding.

FAF1 VCP

1.75e-052146224619421
Pubmed

Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.

FLT4 SEMA3G PLXND1

2.01e-0513146327880905
Pubmed

Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.

NAB2 CNTNAP1 PRX

2.55e-0514146319244508
Pubmed

MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.

RMDN3 FAF2 UBR5 VCP

2.67e-0541146434964862
Pubmed

Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.

DUX4L9 DUX4L2 DUX4L4

3.18e-0515146335727972
Pubmed

Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.

DUX4L9 DUX4L2 DUX4L4

3.18e-0515146330071041
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

TRPM4 DRD2 TPCN2 GPR37 CNTNAP1 PER1 GDF1 PTGER4 SRRT NTNG2 EHMT2 PKD1

4.09e-056971461228298427
Pubmed

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.

FLT4 MARK3 PLXND1

4.72e-0517146322615585
Pubmed

USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork.

FAF1 VCP

5.24e-053146234644576
Pubmed

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.

FAF1 VCP

5.24e-053146226842564
Pubmed

CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.

RASA4 RASA4B

5.24e-053146225637021
Pubmed

Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles.

FRS3 FRS2

5.24e-053146219187780
Pubmed

UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3.

FRS3 FRS2

5.24e-053146216887332
Pubmed

Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway.

FAF1 VCP

5.24e-053146215743842
Pubmed

NVL: a new member of the AAA family of ATPases localized to the nucleus.

NSF VCP

5.24e-05314629286697
Pubmed

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.

FAF2 VCP

5.24e-053146236746962
Pubmed

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids.

FAF1 FAF2

5.24e-053146223720822
Pubmed

Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.

FRS3 FRS2

5.24e-053146215738000
Pubmed

Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.

FAF1 FAF2

5.24e-053146212372427
Pubmed

Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus.

PTGER4 FBLN1

5.24e-053146232640908
Pubmed

FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.

FRS3 FRS2

5.24e-053146211877385
Pubmed

Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.

FRS3 FRS2

5.24e-053146217901128
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

NELFE RBM15 GALK1 NSF MARK3 PFAS RFC4 FAF1 FAF2 UBR5 TNFAIP3 DCAF11 AQR VCP

9.13e-0510051461419615732
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

GALK1 APEH PFAS RFC4 PAPSS1 PGRMC1 RBM39 SRRT UBR5 VCP

9.20e-055341461035032548
Pubmed

MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1.

RASA1 SPRED1

1.04e-044146225202123
Pubmed

The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP.

FAF2 VCP

1.04e-044146223618873
Pubmed

Intracellular trafficking and dynamics of double homeodomain proteins.

DUX4 DUX1

1.04e-044146215709750
Pubmed

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.

NELFE SRRT

1.04e-044146229101316
Pubmed

Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.

RASA4 RASA4B

1.04e-044146216234249
Pubmed

Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements.

DUX1 DUX4L6

1.04e-04414629736770
Pubmed

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

FLT4 GDF1

1.04e-044146228991257
Pubmed

DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.

DUX4L9 DUX4

1.04e-044146219829708
Pubmed

Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation.

RHBDF1 EHMT2

1.04e-044146224078251
Pubmed

Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity.

DRD2 NSF

1.04e-044146215858065
Pubmed

Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis.

FRS3 FRS2

1.04e-044146211335123
Pubmed

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.

FRS3 FRS2

1.04e-04414629660748
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

NELFE RBM15 NSF RFC4 RBM23 RBM39 FAF1 SRRT FAF2 KIF2A VCP

1.04e-046531461133742100
Pubmed

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.

DRD2 MARK3 SRRT SPRED1

1.46e-0463146417672918
Pubmed

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum.

FAF2 VCP

1.74e-045146221909096
Pubmed

Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97.

UBXN7 VCP

1.74e-045146233381997
Pubmed

Three mechanisms assemble central nervous system nodes of Ranvier.

CNTNAP1 BCAN

1.74e-045146223664614
Pubmed

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases.

FLT4 PKD1

1.74e-045146226038530
Pubmed

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

TRPM4 TPCN2

1.74e-045146226571400
Pubmed

RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.

DUX4L2 DUX4

1.74e-045146219359275
Pubmed

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.

FAF2 VCP

1.74e-045146223297223
Pubmed

The PUB domain functions as a p97 binding module in human peptide N-glycanase.

FAF1 VCP

1.74e-045146216807242
Pubmed

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.

RBM23 RBM39

1.74e-045146231686031
Pubmed

Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.

FRS3 FRS2

1.74e-045146216421190
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

SHROOM3 HECTD3 NSF MARK3 MRPL43 FRS2 APEH PFAS ANKLE2 PGRMC1 FAF2 UBR5 EHMT2 PES1 ESPL1 AQR VCP

1.76e-0414871461733957083
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

HECTD3 NSF ANKLE2 PGRMC1 FAF1 RMDN3 FOXRED2 FAF2 UBR5 PES1 CHPF ESPL1 VCP

1.80e-049421461331073040
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

GPC1 MAGEA1 RBM15 GALK1 PFAS RFC4 RBM39 SRRT SMG8 FAF2 PSME4 UBR5 PES1 KIF2A AQR VCP

1.89e-0413531461629467282
Pubmed

Functional proteomics mapping of a human signaling pathway.

FLT4 ANKLE2 MTMR10 FAF1 FBLN1 UBR5 PKD1 SPRED1 TNFAIP3 CHPF

2.09e-045911461015231748
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

NELFE RBM15 WDR33 MRPL43 PUM2 RFC4 RBM39 SRRT PES1 KIF2A AQR

2.24e-047131461129802200
Pubmed

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.

FAM86B1 FAM86B2 EEF2KMT

2.44e-0429146312438443
Pubmed

A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.

WDR33 RBM23 PRX EIF4ENIF1

2.59e-0473146422094256
Pubmed

Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD).

FAF1 VCP

2.60e-046146223293021
Pubmed

Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery.

FLT4 PLXND1

2.60e-046146233870127
Pubmed

Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.

FAF2 VCP

2.60e-046146224160817
Pubmed

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.

MTMR10 UBR5

2.60e-046146232876667
Pubmed

Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta.

RBM23 RBM39

2.60e-046146215694343
Pubmed

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.

DRD2 UBR5

2.60e-046146225594175
Pubmed

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.

FAF2 VCP

2.60e-046146218835813
Pubmed

Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin.

UBXN7 VCP

2.60e-046146226826127
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

NSF MARK3 RFC4 CHRNB2 PES1 UBXN7 HELZ2 RGS17 KIF2A CHPF HSP90AB3P

2.80e-047321461134732716
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

GALK1 NSF RFC4 PGRMC1 FAF2 HSP90AB3P

3.23e-04217146630619736
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

NELFE NSF WDR33 MARK3 MRPL43 PFAS RFC4 PGRMC1 RMDN3 SRRT FBLN1 FAF2 UBR5 PES1 VCP

3.44e-0412841461517353931
Pubmed

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

RFC4 RBM39 UBR5 EHMT2

3.51e-0479146426446488
Pubmed

A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.

FAF2 VCP

3.63e-047146223665563
Cytoband4q35.2

DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

2.51e-102714564q35.2
CytobandEnsembl 112 genes in cytogenetic band chr4q35

DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

4.16e-091171458chr4q35
GeneFamilyPRD class homeoboxes and pseudogenes

DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

5.01e-0792947521
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA1 RASA4 RASA4B

1.59e-0510943830
GeneFamilyUBX domain containing

FAF1 FAF2 UBXN7

3.75e-0513943364
GeneFamilyUPF1 like RNA helicases

HELZ2 AQR

1.43e-03119421169
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

FLT4 SPEG ISLR PXDNL MYOM2

1.53e-03161945593
GeneFamilyAAA ATPases

NSF RFC4 VCP

2.64e-0353943413
ToppCellFibroblasts-CD55+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SPEG CAPS CRTAC1 ISLR C17orf58 SNED1 GPR153 PROS1

1.63e-0719313888f4bf9a2fbedae35432dad96730b00c70185874c
ToppCell356C-Lymphocytic-ILC-ILC-3|ILC / Donor, Lineage, Cell class and subclass (all cells)

NSF CLIC3 PGRMC1 PKD1 TMC8

1.31e-06611385d0b33a48ee2faf68b270f9279c630437f3e8b20b
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLIC3 PRX GPR153 RGS17 MYOM2 HHIPL1

1.62e-051721386073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPC1 HECTD3 CLIC3 ANKLE2 STK35 C9orf50

1.79e-051751386711ace94fa9a763c6ae48171a690953f25deebe4
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

CLIC3 FRS2 PTGER4 CSRNP1 CD7 GPR153

2.09e-051801386310a311c3ed924c912a800cf287a825de44b8775
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SNX20 CSRNP1 CD7 TMC8 TNFAIP3 DCAF11

2.30e-0518313864a1e5bf58d2acd9dbceeef538b6851c1e5e91059
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPEG CNTNAP1 CLIC3 PRX GPR153 MYOM2

2.37e-0518413861c857126c0ea0671f0d60b048efca288d348d653
ToppCellILEUM|World / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PER1 PTGER4 CSRNP1 TNFAIP3 FCRL5 CHPF

2.84e-0519013864395dbd18c14d491f5066a2ddac438a16b1fd7c3
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SHROOM3 ISLR ARHGEF25 C17orf58 FBLN1 GPR153

2.92e-051911386ce80f65bd24b1c4d2152bf45248449e7a1a97e56
ToppCelldroplet-Lung-1m-Mesenchymal|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SHROOM3 ISLR ARHGEF25 C17orf58 FBLN1 GPR153

3.01e-05192138601433bd4794b8bcc51fe4249124a0f4289b9d6e2
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

PER1 WHAMM PTGER4 RBM39 HELZ2 TNFAIP3

3.10e-0519313867256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ISLR ARHGEF25 C17orf58 FBLN1 GPR153 RGS17

3.19e-0519413867826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCellmild_COVID-19-MAIT|mild_COVID-19 / disease group, cell group and cell class (v2)

FLT4 PER1 CSRNP1 CD7 TNFAIP3 SOAT2

3.28e-051951386b99815ec94042da1a2574468331b043d29d70b38
ToppCellmild_COVID-19-MAIT|World / disease group, cell group and cell class (v2)

FLT4 PER1 PTGER4 CSRNP1 CD7 TNFAIP3

3.28e-05195138674f0f709d9b3eed5d7e02a51884f02cc281782f1
ToppCellT_cells-CCR7+_T_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

PER1 PTGER4 CSRNP1 CD7 TMC8 TNFAIP3

3.47e-051971386904430779c42b51d3eec62cf0cdd501b17058d8b
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PTGER4 NLRP6 CSRNP1 CD7 TMC8 TNFAIP3

3.57e-051981386db107a5511571384f26e26c6301aef9a9f2423c4
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-NK_CD56bright|Influenza_Severe / Disease, condition lineage and cell class

FAM86B1 CLIC3 WHAMM PRX CD7 GPR153

3.67e-051991386784e7e7ede2baa28ede600834813e6de2240bfdf
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CLIC3 PTGER4 RBM39 CSRNP1 CD7 MYOM2

3.78e-05200138648ca9269ee3962d13408fef12b5be120759eac52
DiseaseHereditary, Type VII, Motor and Sensory Neuropathy

AMACR PRX

2.86e-0461302C0019816
DiseaseHereditary Motor and Sensory Neuropathies

AMACR PRX

2.86e-0461302C0027888
Diseaselethal congenital contracture syndrome (is_implicated_in)

CNTNAP1 ZBTB42

3.99e-0471302DOID:0060558 (is_implicated_in)
DiseaseDejerine-Sottas Disease (disorder)

AMACR PRX

3.99e-0471302C0011195
Diseaseotosclerosis

PTX4 MARK3 CCSER1 HSP90AB3P

4.60e-04811304EFO_0004213
Diseaseneurodegenerative disease (implicated_via_orthology)

RASA1 MARK3 PPCS MTMR10 VCP

4.68e-041451305DOID:1289 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

DRD2 RASA1 GRK7 CLIC3 CHRNB2

1.76e-031951305DOID:1574 (implicated_via_orthology)
DiseaseSitus ambiguus

SHROOM3 GDF1

1.95e-03151302C0266642
DiseaseWithdrawal Symptoms

DRD2 PER1 CHRNB2

2.16e-03581303C0087169
DiseaseDrug Withdrawal Symptoms

DRD2 PER1 CHRNB2

2.16e-03581303C0086189
DiseaseSubstance Withdrawal Syndrome

DRD2 PER1 CHRNB2

2.16e-03581303C0038587
DiseaseTetralogy of Fallot

FLT4 GDF1

2.22e-03161302C0039685
Diseasegastroparesis

HLA-DRB3 PXDNL

2.22e-03161302EFO_1000948
Diseasehepatitis B virus infection

HLA-DRB3 EHMT2

3.14e-03191302EFO_0004197
Diseasesquamous cell carcinoma

TPCN2 MARK3 DNAH11

3.26e-03671303EFO_0000707
DiseaseCocaine Dependence

DRD2 NSF EHMT2 CCSER1

3.39e-031391304C0600427
Diseaseend stage renal disease (implicated_via_orthology)

PTGER4 SOAT2

3.47e-03201302DOID:783 (implicated_via_orthology)
DiseaseAttention Deficit Disorder

DRD2 CHRNB2

4.20e-03221302C0041671
DiseaseMinimal Brain Dysfunction

DRD2 CHRNB2

4.20e-03221302C1321905

Protein segments in the cluster

PeptideGeneStartEntry
RRPFRLEFVGLVDLD

MAMDC4

611

Q6UXC1
SPRDARFFRRLERPA

EVI5L

756

Q96CN4
RFFRRLERPAKDSEG

EVI5L

761

Q96CN4
VTREPARRLFLFGEE

ANKLE2

816

Q86XL3
VVPTTDRRFRGRIDF

CD7

76

P09564
RQRCPFRVRFADETL

C9orf50

266

Q5SZB4
GFPRRGRLAVSFRFR

CNTNAP1

376

P78357
LLSSRGRERRVFLFE

ARHGEF25

371

Q86VW2
GLARFFRQLDRDGSR

CAPS

111

Q13938
VELEETPFRRFLGER

AIFM3

361

Q96NN9
TPFRRFLGERVGRAL

AIFM3

366

Q96NN9
AGEPQLRESRRRFLD

CLIC3

151

O95833
RAFEKDRFPGIAARE

DUX4L4

111

P0CJ87
DFGARVVRVDRPGSR

AMACR

26

Q9UHK6
AAREARDFREAPTLR

DNAH11

6

Q96DT5
RSFAQDARVRFLGGR

DNAH11

51

Q96DT5
LRFPRIAFFSSRDIR

EHMT2

1131

Q96KQ7
PNLRGESRTFRVFLD

AQR

616

O60306
SLSPFREGRFIERRL

CCSER1

446

Q9C0I3
RAFEKDRFPGIAARE

DUX4L6

111

P0CJ89
GFRRFVRLQEGRPEF

ARHGEF39

126

Q8N4T4
TFRQLFRRVRERFPG

RASA4

441

O43374
DLRFRERRPGLQATA

RBAKDN

51

A6NC62
RVAFVNFRRPEDARA

RBM15

216

Q96T37
RIRPRDLEDFFSAVG

RBM23

176

Q86U06
AARIRPRDLEEFFST

RBM39

161

Q14498
TFRQLFRRVRERFPG

RASA4B

441

C9J798
IRESDRRPGSFVLSF

RASA1

206

P20936
APAGRNLFREFLRTE

RGS17

91

Q9UGC6
RRDGRFLAPRFAVEQ

ADAMTS19

181

Q8TE59
GRSRLLEDFRNNRFP

PUM2

706

Q8TB72
EDRAFRVRIAGDAPL

BCAN

31

Q96GW7
VLRVPAGASRRRAFS

OR11A1

226

Q9GZK7
FERRFLAVRTLRSFP

FAM86B2

16

P0C5J1
RGELPRDSRARFFID

KCTD8

86

Q6ZWB6
RFFFPSLREAALREE

MAGEA1

291

P43355
RAFEKDRFPGIAARE

DUX4

111

Q9UBX2
FRRSDSFPERRAPRK

NELFE

246

P18615
RAFRDGEVRLVRPAG

HHIPL1

666

Q96JK4
FRIVRFRFDESGPES

MTMR10

141

Q9NXD2
VESVERIFRSFPRGD

NAB2

246

Q15742
ARRERPGRVAFDGIT

CSRNP1

76

Q96S65
PRELRLRATRAFVAA

GPC1

206

P35052
EGQLEFRALLFSPRR

HSP90AB3P

266

Q58FF7
EDAPRRARSRALRFP

C17orf58

121

Q2M2W7
RPSRARLELRFAAAA

GDF1

141

P27539
RAFEKDRFPGIAARE

DUX4L3

111

P0CJ86
FIPRDAFRSLRALRS

ISLR

136

O14498
FERRFLAVRTLRSFP

FAM86B1

16

Q8N7N1
RRPDERLRFAVFTGA

GPR26

161

Q8NDV2
RDVFRGTRFSELLAP

PER1

246

O15534
VFPARERLFAVFERP

PLXND1

361

Q9Y4D7
SLERSDVPLRFRFFR

FCRL5

216

Q96RD9
RDFTPAELRRFDGVQ

PGRMC1

71

O00264
PALPRLSDFRRRRSF

PTGER4

246

P35408
FERRFLAARTLRSFP

EEF2KMT

16

Q96G04
ALDLRPDERRFAVFS

DCAF11

256

Q8TEB1
ARRAFREEFGAEPEL

GALK1

16

P51570
LAFAEDAPPSRARRR

GPR153

441

Q6NV75
FRRAFASRVFPPEIV

NSF

231

P46459
RAGRDYAVFERAPRP

FOXRED2

51

Q8IWF2
VFPTIRRRFRNEAER

HECTD4

2261

Q9Y4D8
ARPVRFLDNFSSGRR

PPCS

51

Q9HAB8
FREFTRPEEIIFLRA

FBLN1

606

P23142
RFTARPLVETIFERG

KIF2A

291

O00139
EGRRVAILRNPEFFE

PAPSS1

331

O43252
DLRFNRIREIPGSAF

PXDNL

56

A1KZ92
LAFAGDTRPRFLELR

HLA-DRB3

26

P79483
GDVPLARIQRLFSFR

ESPL1

1666

Q14674
VLRARAPREEQGAAF

GPR37

66

O15354
RVARGSERFRDLVPN

DHH

66

O43323
FAPVFARRLRAGDSV

DHH

286

O43323
RRRDCTPTVFNFDIR

FRS2

411

Q8WU20
TRRRGSPRVFNFDFR

FRS3

391

O43559
RAFEKDRFPGIAARE

DUX4L9

111

Q6RFH8
ERGERVFQREPFRKS

DENND2C

841

Q68D51
RAFEKDRFPGIAARE

DUX4L7

111

P0CJ90
LFLSEDRRSVRRCPF

BTN2A1

341

Q7KYR7
DRIRFPRGTASRSTF

MARK3

551

P27448
RAFEKDRFPGIAARE

DUX1

111

O43812
LRVVPRTRFGAFARG

CRTAC1

446

Q9NQ79
GSFPVNRRRVEAARR

DRD2

261

P14416
LRIRTPSGEFLERRF

FAF1

576

Q9UNN5
RAFEKDRFPGIAARE

DUX4L5

111

P0CJ88
DRQAFRPPTRAELAR

HELZ2

626

Q9BYK8
GRRLFRDFLATVPTF

GRK7

66

Q8WTQ7
LERRFLAARALRSFP

FAM86C2P

16

A6NEL3
TFNRLFRRDEEGRRP

NLRP6

181

P59044
RPPRFQRDFVDLRTD

NOCT

121

Q9UK39
FVRGRPRRFTSFDQV

PKD1

3966

P98161
PFFERLRRLEEQFRR

PTX4

36

Q96A99
FEFRERGRLAIRARS

FSCN2

451

O14926
VRFEVRDRFAIFAGP

NTNG2

211

Q96CW9
GRRRDDIARAFVGFE

SMG8

836

Q8ND04
LAEARRLFPGRVSVD

RSAD1

181

Q9HA92
LRAARLFTRFAEAGR

PIF1

71

Q9H611
AARELFGPELFRLRV

RFC4

91

P35249
FVEREVIDFARRNPG

MRPL43

46

Q8N983
VARRRRFPFVRERSD

RMDN3

136

Q96TC7
IRRRFRAGTAPPAAF

SSPOP

3006

A2VEC9
SERRSPRPIFDLEFR

PRR23B

206

Q6ZRT6
FALRFIRPDPRSRVT

FAF2

116

Q96CS3
IDPLARGRAFRVADD

RHBDF1

156

Q96CC6
FRRRDLELGAPVASR

SHROOM3

941

Q8TF72
RARRAPLGTNFVDRL

NAP1L3

86

Q99457
REGLFAEPERHRLRF

WHAMM

16

Q8TF30
RLPEISRFSAEFDFR

PROS1

316

P07225
DRSVDRFTFRALLPG

SNED1

1056

Q8TER0
FLREAVPGTLRARRG

SOAT2

246

O75908
ALSEPQPERRFFRRG

SRRT

451

Q9BXP5
RQREREGAGALFFRE

CHRNB2

366

P17787
EPFRLGIRFCTNRRS

APEH

266

P13798
REFGDSKRVFGERRR

EIF4ENIF1

196

Q9NRA8
FFGERRIPRGRRISV

ALKBH7

186

Q9BT30
ERVVFLTGARGRRAP

CHPF

146

Q8IZ52
DPRAVFRSRERTKGD

CHST4

206

Q8NCG5
FVREPFERLVSAFRD

CHST8

256

Q9H2A9
RAPRLFEAFDRTETR

CNGA4

146

Q8IV77
RVPFGALFRERRAVV

PRXL2C

46

Q7RTV5
RSREFLDFLTRPELR

SNX20

176

Q7Z614
VAAEAPGEAFLARRR

STK35

176

Q8TDR2
TLPRRLLVDRFSGRF

TMC8

446

Q8IU68
REVPREALAFIIRSF

PES1

336

O00541
RAVPLVNRDRGRFED

TNFAIP3

271

P21580
FFEERRRSLERSDSP

SPEG

406

Q15772
NSIDPALRRFGRFDR

VCP

351

P55072
ALRRFGRFDREVDIG

VCP

356

P55072
FVDAFERRARAQPGR

SLC27A5

116

Q9Y2P5
PADARAFDRGIRRAI

SPRED1

106

Q7Z699
GIFVRELREDSPAAR

PRX

41

Q9BXM0
ELLAGEFTRLEFPRR

PPM1M

271

Q96MI6
AELRRFRKRPDTFSL

PFAS

1141

O15067
LPRVAALSRRQGEDF

ZSCAN5B

186

A6NJL1
RRRPGSSDRVLFARF

FLT4

971

P35916
RRLEEFPAFPRAQVF

SNX15

71

Q9NRS6
AGRFVPDDVRRKFAL

YJEFN3

271

A6XGL0
RDDRVLPLRAIRFFV

PSME4

1176

Q14997
LFYRDRPAGSRDTVR

ZBTB42

51

B2RXF5
ARGPERSRQRFRGFR

ZKSCAN4

46

Q969J2
DARRDFERAARLGSP

TTC36

141

A6NLP5
FERAARLGSPFARRQ

TTC36

146

A6NLP5
TPADLEFSRLRFREF

ZSCAN18

41

Q8TBC5
RRPARSIFDGFRDFQ

UBXN7

101

O94888
TERGLLFRRLSRFDA

SEMA3G

636

Q9NS98
PEDPRFRGRREESFR

WDR33

1091

Q9C0J8
AVDRRAPAGRRTFLT

TREML1

66

Q86YW5
ARQGEARDRIRRFFP

TRPM4

326

Q8TD43
ARDRIRRFFPKGDLE

TRPM4

331

Q8TD43
SLFRRRLGTRAAFEV

TPCN2

326

Q8NHX9
DRDFRRQLSIDTRPF

UBR5

2361

O95071
RAFEKDRFPGIAARE

DUX4L2

111

P0CJ85
RFLAEAARSLRAGRP

HECTD3

21

Q5T447
VRRFRGDEEPFRSVG

MYOM2

246

P54296