Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainFBA

FBXO6 FBXO44 FBXO2

2.10e-076423PS51114
DomainFBA

FBXO6 FBXO44 FBXO2

2.10e-076423PF04300
DomainFBA

FBXO6 FBXO44 FBXO2

2.10e-076423SM01198
DomainF-box-assoc_dom

FBXO6 FBXO44 FBXO2

2.10e-076423IPR007397
DomainF-box

FBXO22 FBXO6 FBXO44 FBXO2

1.53e-0567424PF00646
DomainFBOX

FBXO22 FBXO6 FBXO44 FBXO2

2.03e-0572424PS50181
DomainF-box_dom

FBXO22 FBXO6 FBXO44 FBXO2

2.39e-0575424IPR001810
DomainFBOX

FBXO22 FBXO6 FBXO44

2.16e-0452423SM00256
DomainSCAN

ZSCAN29 ZSCAN20 ZSCAN30

2.70e-0456423SM00431
DomainSCAN_BOX

ZSCAN29 ZSCAN20 ZSCAN30

2.99e-0458423PS50804
DomainSCAN

ZSCAN29 ZSCAN20 ZSCAN30

2.99e-0458423PF02023
DomainSCAN_dom

ZSCAN29 ZSCAN20 ZSCAN30

2.99e-0458423IPR003309
DomainRetrov_capsid_C

ZSCAN29 ZSCAN20 ZSCAN30

3.15e-0459423IPR008916
Domain-

FBXO6 FBXO44 FBXO2

5.89e-04734232.60.120.260
DomainGalactose-bd-like

FBXO6 FBXO44 FBXO2

1.23e-0394423IPR008979
DomainWD40

WDR38 WDR4 PRPF4 NBEAL1

2.67e-03259424PF00400
DomainWD40

WDR38 WDR4 PRPF4 NBEAL1

3.02e-03268424SM00320
DomainWD40_repeat

WDR38 WDR4 PRPF4 NBEAL1

3.19e-03272424IPR001680
DomainWD_REPEATS_1

WDR38 WDR4 PRPF4 NBEAL1

3.45e-03278424PS00678
DomainWD_REPEATS_2

WDR38 WDR4 PRPF4 NBEAL1

3.49e-03279424PS50082
DomainWD_REPEATS_REGION

WDR38 WDR4 PRPF4 NBEAL1

3.49e-03279424PS50294
DomainWD40_repeat_dom

WDR38 WDR4 PRPF4 NBEAL1

4.36e-03297424IPR017986
DomainF-box-like

FBXO6 FBXO44

4.40e-0344422PF12937
Domain-

WDR38 WDR4 PRPF4 NBEAL1

6.52e-033334242.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR38 WDR4 PRPF4 NBEAL1

6.65e-03335424IPR015943
DomainLRR_6

PHLPP1 NLRP12

6.80e-0355422PF13516
DomainLRR

PHLPP1 LINGO3 NLRP12

1.04e-02201423PS51450
PathwayREACTOME_TRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL

LAGE3 WDR4 TRMT44

6.55e-0543263M27602
Pubmed

A new subfamily of structurally related human F-box proteins.

FBXO6 FBXO44 FBXO2

2.16e-08546312383498
Pubmed

A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.

FBXO6 FBXO44 FBXO2

7.55e-08746317215248
Pubmed

Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.

FBXO6 FBXO44 FBXO2

1.21e-07846318203720
Pubmed

Identification of a family of human F-box proteins.

FBXO22 FBXO6 FBXO44 FBXO2

1.71e-073746410531035
Pubmed

A family of mammalian F-box proteins.

FBXO22 FBXO6 FBXO44 FBXO2

2.89e-074246410531037
Pubmed

Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.

FBXO22 FBXO6 FBXO44 FBXO2

1.41e-066246429103612
Pubmed

FBXO22, ubiquitination degradation of PHLPP1, ameliorates rotenone induced neurotoxicity by activating AKT pathway.

PHLPP1 FBXO22

1.71e-06246234182063
Pubmed

Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function.

LRP1 PDGFRB

1.71e-06246215944146
Pubmed

Expression of LRP1 and CHOP genes associated with peripheral neuropathy in type 2 diabetes mellitus: Correlations with nerve conduction studies.

LRP1 DDIT3

1.71e-06246230902789
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

FBXO22 FBXO6 FBXO44 FBXO2

5.01e-068546419028597
Pubmed

The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events.

LRP1 PDGFRB

5.13e-06346223922991
Pubmed

Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta).

LRP1 PDGFRB

5.13e-06346215753096
Pubmed

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.

LRP1 PDGFRB

5.13e-06346219066283
Pubmed

The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.

FBXO44 FBXO2

5.13e-06346226460611
Pubmed

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.

LRP1 PDGFRB

5.13e-06346219742316
Pubmed

Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.

FBXO6 FBXO2

1.03e-05446217494702
Pubmed

Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.

FBXO6 FBXO2

1.03e-05446234215698
Pubmed

Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates.

FBXO6 FBXO2

1.03e-05446215723043
Pubmed

Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.

FBXO6 FBXO2

1.71e-05546212939278
Pubmed

The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.

LRP1 PDGFRB

4.77e-05846225377550
Pubmed

Skp1 stabilizes the conformation of F-box proteins.

FBXO6 FBXO44

4.77e-05846221640084
Pubmed

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.

FBXO22 FBXO6 FBXO44

5.41e-055546337028429
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CACNA1G SFI1 TRANK1 WASHC5 HAUS5 HECTD4

6.73e-0552946614621295
Pubmed

Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction.

CACNA1G MED13L

7.65e-051046232672536
Pubmed

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells.

FBXO6 FBXO2

7.65e-051046231210753
Pubmed

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.

FBXO22 FBXO6

1.54e-041446226087183
Pubmed

Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.

FBXO22 FBXO6

2.30e-041746231130363
Pubmed

Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.

PDGFRB SPNS2

2.58e-041846235977478
Pubmed

Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.

MED13L HECTD4

3.54e-042146225249183
Pubmed

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

PRPF4 BAZ1A DDIT3

3.59e-0410446326167872
Pubmed

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.

PDGFRB DDIT3

5.04e-042546230604742
Pubmed

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.

PHLPP1 FBXO2

5.45e-042646225820252
Pubmed

Array MAPPIT: high-throughput interactome analysis in mammalian cells.

FBXO44 FBXO2

5.45e-042646219159283
InteractionLIFR interactions

LRP1 FBXO6 PRPF4 FBXO2

2.08e-0644424int:LIFR
Cytoband1p36.22

FBXO6 FBXO44 FBXO2

7.14e-06374631p36.22
GeneFamilyCyclins|F-boxes other

FBXO22 FBXO6 FBXO44 FBXO2

7.23e-0739334560
GeneFamilyWD repeat domain containing

WDR38 WDR4 PRPF4 NBEAL1

1.27e-03262334362
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PLA2R1 PDGFRB ABCA8

3.18e-05175464795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PLA2R1 PDGFRB ABCA8

3.86e-05184464e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB TFPI2 ABCA8

4.03e-05186464f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLA2R1 PDGFRB ABCA8 UBTFL1

4.11e-0518746476bfe8c42430a230a8bdf299575c444fb7780f24
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2R1 CACNA1G PDGFRB TFPI2

4.38e-051904648cb950effc449ae59a915132ecc079be54d1acfe
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2R1 CACNA1G PDGFRB TFPI2

4.38e-0519046417a73a658fb30a4322b31e38db7b240023738f29
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2R1 CACNA1G PDGFRB TFPI2

4.38e-051904645dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PLA2R1 PDGFRB ABCA8

4.47e-05191464a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PLA2R1 PDGFRB ABCA8

4.47e-051914648f6d592edc32fdb901af30501d4360512334e8c2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 TRANK1 PDGFRB ABCA8

4.75e-0519446481713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 TRANK1 PDGFRB ABCA8

4.75e-05194464c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 TRANK1 PDGFRB ABCA8

4.75e-05194464627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC26A7 PDGFRB ABCA8 SPNS2

5.04e-051974645fbbc570a4e77c703f569a4f85ce2d8af67d6297
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB TFPI2 ABCA8

5.04e-05197464ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCell5'-Adult-Appendix-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB TFPI2 ABCA8

5.04e-05197464b11a5d909942a4299cbc0b27332b1a3f66f3bccd
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LRP1 CACNA1G PDGFRB ABCA8

5.34e-0520046458b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

WDR38 OTOF SPNS2

2.65e-041214634765e6ec00b0cf10d08cbd738c68a51d21bfb625
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHLA2 XKR7 ABCA8

2.91e-04125463b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

WDR38 OTOF SPNS2

2.98e-0412646310e1448a03f79965b72922fd83ef51de1b7b474f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

ZSCAN20 FBXO6 TMEM81

3.05e-041274639071cd0953c8bb6746dc9cd13d153e3d6ef40b08
ToppCellPosterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLA2R1 PDGFRB TFPI2

3.65e-04135463e908aacb72a8c340f06cf5b4a6b70c2faac4d027
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-3|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

LRP1 NLRP12 XKR7

3.73e-041364634f5e0b6c7d6e3e922af4daa7c3eb56490455c1df
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PLA2R1 PDGFRB UBTFL1

4.32e-041434639bfb3674c8f011b9cf928b522777b8d54478db8d
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PHLPP1 ZSCAN30 SPNS2

4.41e-0414446357d2846ec26d4490ec11c171af447b17a729437e
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PHLPP1 ZSCAN30 SPNS2

4.96e-04150463b6f1fc62d08199fed6156c7cd32f66d9926531b5
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

LRP1 PDGFRB

4.97e-0432462ba89b22a5ce8ee9f3099b1fa84721724b94c7759
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

LRP1 PDGFRB

4.97e-043246258b212d4f2955f06a195df0f79ad95a8ff145b83
ToppCell367C-Fibroblasts-Fibroblast-D-|367C / Donor, Lineage, Cell class and subclass (all cells)

LRP1 PDGFRB ABCA8

5.36e-04154463dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell367C-Fibroblasts-Fibroblast-D|367C / Donor, Lineage, Cell class and subclass (all cells)

LRP1 PDGFRB ABCA8

5.36e-041544634bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCellNS-critical-d_0-4-Lymphoid-NKT|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CACNA1G HAUS5 TMEM81

5.36e-0415446308ffa4b6f4a1c3de037acf9d30bd14c195738ad9
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSCAN29 PDGFRB TMEM81

5.67e-04157463d8e283414a770f05d71f0455d0822e9a9660b115
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSCAN29 PDGFRB TMEM81

5.67e-04157463165e98bf944572cafbc06ef43c9eab7bd6bea1c2
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC26A7 PDGFRB SPNS2

5.67e-04157463c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 DCST1 ABCA8

6.10e-04161463a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XKR7 TFPI2 FBXO2

6.21e-04162463ed9ee98d6568b0ac2cd3af1d58a17364ff2cfa22
ToppCell356C-Fibroblasts-Fibroblast-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

PLA2R1 CEP112 ABCA8

6.66e-041664637c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell356C-Fibroblasts-Fibroblast-D|356C / Donor, Lineage, Cell class and subclass (all cells)

PLA2R1 CEP112 ABCA8

6.66e-041664637286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCelldroplet-Kidney-nan-24m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NLRP12 OTOF

6.78e-041674632ee1660be117e20f24557522345572d11cbee813
ToppCell367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|367C / Donor, Lineage, Cell class and subclass (all cells)

PDGFRB TFPI2 ABCA8

7.02e-0416946347fd4adfe54777e69a0fabf8bd34f26223f63275
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOF BAZ1A SPNS2

7.02e-041694634126b20df9e85f028807482a51e20a300faa74c2
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LINGO3 WDR4 ZSCAN30

7.02e-04169463a3234904d7ff8f451ca894e93badd61d75e3cd2a
ToppCell367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|367C / Donor, Lineage, Cell class and subclass (all cells)

PDGFRB TFPI2 ABCA8

7.02e-04169463e09259d62cd3e42f0919f231ed1164db59b0b6c3
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2R1 PDGFRB CEP112

7.02e-0416946387116c33c5ca8cb1862e103e5607b1df4d264569
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 PDGFRB HECTD4

7.14e-041704635570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellCOVID-19_Mild-PLT_2|COVID-19_Mild / Disease Group and Platelet Clusters

FBXO22 TARS2 HAUS5

7.51e-04173463d11705e56b6b21eec963ea224717f27680c781ed
ToppCelldroplet-Marrow-nan-24m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPDC1 PDGFRB SPNS2

7.64e-04174463955a3de6b7efc117f34c14faf8051f41454275dd
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 PDGFRB ABCA8

7.89e-041764632e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 PDGFRB ABCA8

7.89e-04176463f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellwk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLA2R1 SFI1 CEP112

8.16e-04178463a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCellwk_15-18-Mesenchymal-Mesothelial-intermediate_mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NPDC1 TFPI2 SPNS2

8.29e-04179463b1f085e4c8d65d5cdbfaf2db80343638abb08979
ToppCell367C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TARS2 WASHC5 HAUS5

8.29e-041794635aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

8.42e-04180463ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ABCA8 ZNF295-AS1

8.42e-04180463fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC26A7 TFPI2 SPNS2

8.42e-04180463f103e161e966c257eac97e1b30a461c4ed9cafc2
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ABCA8 ZNF295-AS1

8.42e-04180463280ff5c8f292be1b88120db5ff1788b750644856
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB TFPI2

8.56e-041814636d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

8.56e-04181463c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

8.56e-04181463c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod|TCGA-Mesothelium / Sample_Type by Project: Shred V9

TRANK1 FBXO44 FBXO2

8.70e-04182463bb1f815718397de96682697fcbd6014a992a28f7
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB ABCA8

8.70e-041824633dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellwk_08-11-Endothelial-Blood_vessel_endothelial-Late_cap|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

WDR38 NPDC1 SPNS2

8.84e-041834633e69cc605f166a1f04e3d077935f7cfd806f1ffd
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB ABCA8

9.12e-041854639faa35ceb89ccd2979072286f063687c9f846ce3
ToppCelldroplet-Marrow-nan-18m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPDC1 PDGFRB SPNS2

9.12e-04185463de353368f4f6a7a0a66e391d586879876fbe2734
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

LRP1 MED13L HECTD4

9.12e-041854631d874608aa2062024323512f68889219471b2f00
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1G CEP112 FBXO2

9.26e-04186463cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 PLA2R1 PDGFRB

9.26e-04186463cc94e0c5d1665d2ea2bb871ad79d8e1ec2249fb5
ToppCelldroplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1G CEP112 FBXO2

9.26e-04186463b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB ABCA8

9.26e-041864637582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PLA2R1 PDGFRB

9.40e-04187463ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PLA2R1 PDGFRB

9.40e-04187463d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell10x3'2.3-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC26A7 PDGFRB ABCA8

9.40e-04187463f1d0fc625e0e7881b3f290742fd7148d995eb71e
ToppCell10x3'2.3-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC26A7 PDGFRB ABCA8

9.40e-0418746302e7246ef5ad41773d14426254e139b156d45c1d
ToppCell10x3'2.3-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC26A7 PDGFRB ABCA8

9.40e-0418746308c73d125e0638c9e9878165bba2442c266c8a48
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

NPDC1 TFPI2 SPNS2

9.40e-0418746303de3c2df31bca0dc4e3718bada708d8fe8b69b9
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PLA2R1 PDGFRB

9.40e-04187463d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NPDC1 TFPI2 SPNS2

9.55e-04188463366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WDR38 FBXO6 XAGE1A

9.55e-04188463f955f2eb92f399958d4d713e31af77d93fb4a6ec
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 TRANK1 ABCA8

9.55e-04188463ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell3'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHLA2 ZSCAN30 HAUS5

9.70e-041894637dad62bd50c197838058e89abd0ee387de3e83cd
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB ABCA8

9.70e-04189463f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRANK1 CEP112 HAUS5

9.70e-04189463bccb3481ffed597c845fe860da658505316105b5
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1G PDGFRB TFPI2

9.70e-0418946329287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1G PDGFRB TFPI2

9.70e-041894637150dad9a92a715487c2d8130fa01b752ea69663
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 PDGFRB ABCA8

9.70e-04189463d531399749409d614adca13d181830c6e3287508
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 PDGFRB ABCA8

9.70e-041894632a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1G PDGFRB TFPI2

9.70e-041894636e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 PDGFRB TFPI2

9.85e-04190463bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

9.85e-041904631f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 PDGFRB TFPI2

9.85e-04190463e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NPDC1 TFPI2 SPNS2

9.85e-041904631307688255a1250fa300edf2c41f1affe31dcc98
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

9.85e-041904632306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 TRANK1 ABCA8

9.85e-04190463efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 PDGFRB TFPI2

9.85e-04190463ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PHLPP1 PDGFRB ABCA8

9.85e-041904632de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

1.00e-0319146339092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

1.00e-03191463a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellfacs-Aorta-Heart-18m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 PDGFRB DDIT3

1.00e-031914636242f83acaf1714e9c1771a832cb67674b19e96d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PDGFRB ABCA8

1.00e-03191463107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NPDC1 SLC26A7 SPNS2

1.00e-0319146354029b68fb78163c969890886ab0f8fb0dcf3c20
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 PDGFRB ABCA8

1.00e-031914634e4488380379ed29d7898bae4e24221e7c67eb9d
Diseaseprotein fam107a measurement

NLRP12 CEP112

2.17e-055442EFO_0020673
DiseaseGalloway Mowat syndrome

LAGE3 WDR4

6.05e-058442C0795949
Diseasemonocyte percentage of leukocytes

PHLPP1 NPDC1 NLRP12 MED13L POLR1A PDGFRB

7.17e-04731446EFO_0007989

Protein segments in the cluster

PeptideGeneStartEntry
LRRNLLLQAWKCVCN

CDRT15L2

251

A8MXV6
LLLCCVWRLCRKQTV

ANTXRL

366

A6NF34
ERQRCALWIRKLCEP

CEP112

36

Q8N8E3
RQLLLNCRLVCSLWR

FBXO6

31

Q9NRD1
IWSKSILNARCKICR

BAZ1A

1141

Q9NRL2
ISDWLKRICCINRQS

NBEAL1

466

Q6ZS30
ALLRVACVCRLWREC

FBXO22

41

Q8NEZ5
ACVCRLWRECVRRVL

FBXO22

46

Q8NEZ5
IRCLQANLLCVWRRD

MED13L

61

Q71F56
SITKRCIPRVWVCDR

LRP1

3461

Q07954
ELVQACRLVCLRWKE

FBXO2

66

Q9UK22
LLLNCRLVCSLWRDL

FBXO44

26

Q9H4M3
LIWSVKCCRAQLEAR

HHLA2

361

Q9UM44
VRWKAEDCRLLRISV

LAGE3

106

Q14657
CDCRLLWIVQRRKTL

LINGO3

356

P0C6S8
VLILGLRRCCLWTEL

HAUS5

341

O94927
CQELLRSKLLQRCQW

HECTD4

806

Q9Y4D8
VASLCWCRLQREIRL

NPDC1

201

Q9NQX5
WNLRRECSRRKCIFI

DDIT3

16

P0DPQ6
VRAWIRARLPACCLE

CACNA1G

1236

O43497
PLLRRWLCRRCVVCQ

DCST1

636

Q5T197
WNTTVRLLRRCRVLC

OTOF

1241

Q9HC10
IIWSACRDLKRCPRE

PDGFRB

446

P09619
RWRCLRLQGLQACRL

TARS2

6

Q9BW92
RAVRRCATLWKQKVL

SFI1

921

A8K8P3
KQRLLSEACKTRLCW

TRMT44

706

Q8IYL2
RLRTLLQLKWQRSLC

POLR1A

1191

O95602
CKVWDLRQRRCVYTI

PRPF4

431

O43172
RWCRLKTQRADPLVC

SPNS2

386

Q8IVW8
CDSTLVSLRWRCNRK

PLA2R1

106

Q13018
WRQQICAIARVRLLK

ABCA8

841

O94911
KLLNCLRDCNVAIRW

WASHC5

361

Q12768
LSRLRELCCQWLRPE

ZSCAN30

66

Q86W11
RRCCRLCIWLLQTLV

XKR7

171

Q5GH72
CRLKWLEISCNLRKF

UBTFL1

56

P0CB47
CCRWLRPEIRLKEQI

ZSCAN20

76

P17040
RRKCQTRRLECLTNW

TMEM81

71

Q6P7N7
TVRLWDVARAKCLRV

WDR38

86

Q5JTN6
RWTRRQVILCGTCLI

PHLPP1

556

O60346
RIQLRSQCATWKVIC

XAGE1A

26

Q9HD64
KPWQCLSVRTVARRC

WDR4

91

P57081
KRVCASLCRVLAVTW

ZNF295-AS1

61

Q8N0V1
CWRIEKVPKVCRLQV

TFPI2

86

P48307
ELCCRWLRPEVRTKE

ZSCAN29

41

Q8IWY8
RACLVVSLCISWRRR

TRANK1

2681

O15050
CEDIIQWCRRRLPIL

SLC26A7

21

Q8TE54
CRLRTLWLKICRLTA

NLRP12

856

P59046