Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	apolipoprotein binding	LPA TREM2 PLG	2.43e-05	20	57	3	GO:0034185
GeneOntologyMolecularFunction	serine-type peptidase activity	LPA NUP98 TMPRSS2 PLG TPSG1 PRSS36	2.70e-05	207	57	6	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	LPA NUP98 TMPRSS2 PLG TPSG1 PRSS36	3.08e-05	212	57	6	GO:0017171
GeneOntologyMolecularFunction	serine-type endopeptidase activity	LPA TMPRSS2 PLG TPSG1 PRSS36	2.07e-04	190	57	5	GO:0004252
GeneOntologyMolecularFunction	arylsulfatase activity	SULF2 GALNS	7.13e-04	14	57	2	GO:0004065
GeneOntologyMolecularFunction	protein antigen binding	LPA PLG	9.36e-04	16	57	2	GO:1990405
GeneOntologyMolecularFunction	glycosaminoglycan binding	SULF2 LPA C6orf15 TREM2 ADAMTS5	9.94e-04	268	57	5	GO:0005539
GeneOntologyMolecularFunction	sulfuric ester hydrolase activity	SULF2 GALNS	1.06e-03	17	57	2	GO:0008484
GeneOntologyMolecularFunction	extracellular matrix binding	C6orf15 ADAMTS5 BCAM	1.19e-03	73	57	3	GO:0050840
GeneOntologyMolecularFunction	endopeptidase activity	LPA TMPRSS2 ADAMTS5 PLG TPSG1 PRSS36	1.38e-03	430	57	6	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	LPA NUP98 TMPRSS2 ADAMTS5 PLG TPSG1 PRSS36	2.50e-03	654	57	7	GO:0008233
GeneOntologyBiologicalProcess	positive regulation of fibrinolysis	LPA PLG	7.46e-05	5	57	2	GO:0051919
GeneOntologyBiologicalProcess	tissue remodeling	PPARGC1B FLT4 NOL3 LPA CSPG4 PLG	8.37e-05	262	57	6	GO:0048771
GeneOntologyBiologicalProcess	regulation of hippocampal neuron apoptotic process	TREM2 CX3CL1	1.12e-04	6	57	2	GO:0110089
GeneOntologyBiologicalProcess	trans-synaptic signaling by BDNF, modulating synaptic transmission	LPA PLG	1.56e-04	7	57	2	GO:0099183
GeneOntologyBiologicalProcess	positive regulation of microglial cell migration	TREM2 CX3CL1	1.56e-04	7	57	2	GO:1904141
GeneOntologyBiologicalProcess	regulation of cytokine-mediated signaling pathway	NOL3 HPX TREM2 GIGYF2 OAS3	1.92e-04	193	57	5	GO:0001959
GeneOntologyBiologicalProcess	trans-synaptic signaling by BDNF	LPA PLG	2.08e-04	8	57	2	GO:0099191
GeneOntologyBiologicalProcess	hippocampal neuron apoptotic process	TREM2 CX3CL1	2.08e-04	8	57	2	GO:0110088
GeneOntologyBiologicalProcess	regulation of microglial cell migration	TREM2 CX3CL1	2.08e-04	8	57	2	GO:1904139
GeneOntologyBiologicalProcess	negative regulation of cytokine-mediated signaling pathway	NOL3 TREM2 GIGYF2 OAS3	2.11e-04	106	57	4	GO:0001960
GeneOntologyBiologicalProcess	negative regulation of response to cytokine stimulus	NOL3 TREM2 GIGYF2 OAS3	2.52e-04	111	57	4	GO:0060761
GeneOntologyBiologicalProcess	regulation of response to cytokine stimulus	NOL3 HPX TREM2 GIGYF2 OAS3	2.54e-04	205	57	5	GO:0060759
GeneOntologyBiologicalProcess	microglial cell proliferation	TREM2 CX3CL1	2.67e-04	9	57	2	GO:0061518
GeneOntologyBiologicalProcess	microglial cell migration	TREM2 CX3CL1	2.67e-04	9	57	2	GO:1904124
GeneOntologyBiologicalProcess	positive regulation of humoral immune response mediated by circulating immunoglobulin	HPX TREM2	2.67e-04	9	57	2	GO:0002925
GeneOntologyBiologicalProcess	cellular component disassembly	LPA CECR2 TREM2 TRIOBP GIGYF2 ADAMTS5 PLG CX3CL1	2.78e-04	617	57	8	GO:0022411
GeneOntologyBiologicalProcess	peptidyl-tyrosine phosphorylation	FLT4 CSPG4 HPX TREM2 ZZEF1 IL9R	2.79e-04	327	57	6	GO:0018108
GeneOntologyBiologicalProcess	peptidyl-tyrosine modification	FLT4 CSPG4 HPX TREM2 ZZEF1 IL9R	2.88e-04	329	57	6	GO:0018212
MousePheno	abnormal mammary gland connective tissue morphology	LPA PLG	1.25e-05	2	50	2	MP:0009507
MousePheno	esophageal ulcer	LPA PLG	1.25e-05	2	50	2	MP:0004547
MousePheno	duodenal ulcer	LPA PLG	1.25e-05	2	50	2	MP:0003273
MousePheno	perianal ulcer	LPA PLG	1.25e-05	2	50	2	MP:0005035
MousePheno	ectropion	LPA PLG	1.25e-05	2	50	2	MP:0006164
MousePheno	absent cornea epithelium	LPA PLG	3.75e-05	3	50	2	MP:0020856
MousePheno	increased circulating fibrinogen level	LPA PLG	7.49e-05	4	50	2	MP:0012331
MousePheno	proctitis	LPA PLG	7.49e-05	4	50	2	MP:0003305
MousePheno	intestinal ulcer	MISP LPA PLG	8.27e-05	24	50	3	MP:0000512
MousePheno	gastrointestinal ulcer	MISP LPA PLG	1.80e-04	31	50	3	MP:0003300
MousePheno	gastric ulcer	LPA PLG	1.86e-04	6	50	2	MP:0003282
MousePheno	increased acute phase protein level	LPA PLG	2.60e-04	7	50	2	MP:0014499
MousePheno	abnormal conjunctival epithelium morphology	LPA PLG	2.60e-04	7	50	2	MP:0004481
MousePheno	venoocclusion	LPA PLG	2.60e-04	7	50	2	MP:0006137
MousePheno	peptic ulcer	LPA PLG	2.60e-04	7	50	2	MP:0003301
MousePheno	decreased keratinocyte migration	LPA PLG	3.46e-04	8	50	2	MP:0012194
MousePheno	abnormal circulating fibrinogen level	LPA PLG	3.46e-04	8	50	2	MP:0010213
MousePheno	decreased susceptibility to induced choroidal neovascularization	LPA PLG	5.54e-04	10	50	2	MP:0003434
MousePheno	gallstones	GPBAR1 PCTP	5.54e-04	10	50	2	MP:0002830
MousePheno	abnormal kidney thrombosis	LPA PLG	5.54e-04	10	50	2	MP:0011507
MousePheno	abnormal keratinocyte migration	LPA PLG	6.76e-04	11	50	2	MP:0012192
MousePheno	increased macrophage apoptosis	TREM2 PCTP	6.76e-04	11	50	2	MP:0011080
MousePheno	fused inner hair cell stereocilia	TRIOBP SLC7A14	8.09e-04	12	50	2	MP:0004533
MousePheno	abnormal anus morphology	LPA PLG	9.54e-04	13	50	2	MP:0005034
MousePheno	abnormal conjunctiva morphology	LPA PLG	9.54e-04	13	50	2	MP:0001310
Domain	TRYPSIN_HIS	LPA TMPRSS2 PLG TPSG1 PRSS36	1.29e-05	103	55	5	IPR018114
Domain	TRYPSIN_SER	LPA TMPRSS2 PLG TPSG1 PRSS36	1.49e-05	106	55	5	PS00135
Domain	TRYPSIN_HIS	LPA TMPRSS2 PLG TPSG1 PRSS36	1.56e-05	107	55	5	PS00134
Domain	Peptidase_S1A	LPA TMPRSS2 PLG TPSG1 PRSS36	2.03e-05	113	55	5	IPR001314
Domain	TRYPSIN_DOM	LPA TMPRSS2 PLG TPSG1 PRSS36	2.21e-05	115	55	5	PS50240
Domain	Tryp_SPc	LPA TMPRSS2 PLG TPSG1 PRSS36	2.40e-05	117	55	5	SM00020
Domain	Trypsin	LPA TMPRSS2 PLG TPSG1 PRSS36	2.82e-05	121	55	5	PF00089
Domain	Trypsin_dom	LPA TMPRSS2 PLG TPSG1 PRSS36	2.82e-05	121	55	5	IPR001254
Domain	Peptidase_S1_PA	LPA TMPRSS2 PLG TPSG1 PRSS36	3.05e-05	123	55	5	IPR009003
Domain	Sulfatase_CS	SULF2 GALNS	9.95e-04	16	55	2	IPR024607
Domain	Kringle	LPA PLG	1.13e-03	17	55	2	IPR000001
Domain	SULFATASE_1	SULF2 GALNS	1.13e-03	17	55	2	PS00523
Domain	Kringle_CS	LPA PLG	1.13e-03	17	55	2	IPR018056
Domain	KRINGLE_2	LPA PLG	1.13e-03	17	55	2	PS50070
Domain	Kringle	LPA PLG	1.13e-03	17	55	2	PF00051
Domain	KRINGLE_1	LPA PLG	1.13e-03	17	55	2	PS00021
Domain	SULFATASE_2	SULF2 GALNS	1.13e-03	17	55	2	PS00149
Domain	KR	LPA PLG	1.13e-03	17	55	2	SM00130
Domain	Sulfatase	SULF2 GALNS	1.26e-03	18	55	2	PF00884
Domain	Sulfatase_N	SULF2 GALNS	1.26e-03	18	55	2	IPR000917
Domain	TRYPSIN_SER	TMPRSS2 PLG PRSS36	2.37e-03	90	55	3	IPR033116
Domain	-	CHERP SNAP91	2.64e-03	26	55	2	1.25.40.90
Domain	CARD	NOL3 CARD10	3.06e-03	28	55	2	PF00619
Domain	ENTH_VHS	CHERP SNAP91	3.29e-03	29	55	2	IPR008942
Domain	CARD	NOL3 CARD10	3.75e-03	31	55	2	IPR001315
Domain	Alkaline_phosphatase_core	SULF2 GALNS	3.75e-03	31	55	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	SULF2 GALNS	3.75e-03	31	55	2	IPR017849
Domain	-	SULF2 GALNS	3.75e-03	31	55	2	3.40.720.10
Domain	Kringle-like	LPA PLG	3.99e-03	32	55	2	IPR013806
Domain	CARD	NOL3 CARD10	4.24e-03	33	55	2	PS50209
Domain	LDLR_class-A_CS	TMPRSS2 MAMDC4	6.18e-03	40	55	2	IPR023415
Domain	-	TMPRSS2 MAMDC4	8.11e-03	46	55	2	4.10.400.10
Domain	LDLRA_1	TMPRSS2 MAMDC4	8.81e-03	48	55	2	PS01209
Domain	LDLRA_2	TMPRSS2 MAMDC4	9.16e-03	49	55	2	PS50068
Domain	LDrepeatLR_classA_rpt	TMPRSS2 MAMDC4	9.16e-03	49	55	2	IPR002172
Domain	LDLa	TMPRSS2 MAMDC4	9.16e-03	49	55	2	SM00192
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD MTA2 SIPA1L3 CSPG4 ZER1 DISP2 CARD10 TNRC6C BCAM ANKHD1 ZZEF1 TESK1	3.42e-07	1105	60	12	35748872
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PRUNE2 SULF2 SIPA1L3 TRIOBP GIGYF2 TNRC6C	2.56e-06	225	60	6	12168954
Pubmed	Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.	LPA PLG	2.93e-06	2	60	2	31690812
Pubmed	Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.	LPA PLG	2.93e-06	2	60	2	30254165
Pubmed	Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.	LPA PLG	2.93e-06	2	60	2	38328826
Pubmed	Reduced transplant arteriosclerosis in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	9819364
Pubmed	Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	10634603
Pubmed	Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.	LPA PLG	2.93e-06	2	60	2	23943648
Pubmed	In vivo plasminogen deficiency reduces fat accumulation.	LPA PLG	2.93e-06	2	60	2	12083480
Pubmed	Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.	LPA PLG	2.93e-06	2	60	2	18420257
Pubmed	Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.	LPA PLG	2.93e-06	2	60	2	7705657
Pubmed	Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.	LPA PLG	2.93e-06	2	60	2	23041318
Pubmed	Plasminogen alleles influence susceptibility to invasive aspergillosis.	LPA PLG	2.93e-06	2	60	2	18566672
Pubmed	A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.	LPA PLG	2.93e-06	2	60	2	19752236
Pubmed	Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.	LPA PLG	2.93e-06	2	60	2	6216475
Pubmed	The generation and characterization of mice expressing a plasmin-inactivating active site mutation.	LPA PLG	2.93e-06	2	60	2	20653841
Pubmed	Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.	LPA PLG	2.93e-06	2	60	2	12428098
Pubmed	Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.	LPA PLG	2.93e-06	2	60	2	20440070
Pubmed	Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.	LPA PLG	2.93e-06	2	60	2	24732409
Pubmed	A central role for plasminogen in the inflammatory response to biomaterials.	LPA PLG	2.93e-06	2	60	2	15456492
Pubmed	Plasminogen promotes macrophage phagocytosis in mice.	LPA PLG	2.93e-06	2	60	2	24876560
Pubmed	Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.	LPA PLG	2.93e-06	2	60	2	24574269
Pubmed	Spontaneous development of otitis media in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	16956791
Pubmed	Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.	LPA PLG	2.93e-06	2	60	2	25409527
Pubmed	The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.	LPA PLG	2.93e-06	2	60	2	1543918
Pubmed	Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.	LPA PLG	2.93e-06	2	60	2	8704243
Pubmed	Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.	LPA PLG	2.93e-06	2	60	2	17267741
Pubmed	Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.	LPA PLG	2.93e-06	2	60	2	23702659
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.	LPA PLG	2.93e-06	2	60	2	29990619
Pubmed	Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.	LPA PLG	2.93e-06	2	60	2	17293777
Pubmed	Plasminogen plays a crucial role in bone repair.	LPA PLG	2.93e-06	2	60	2	23456978
Pubmed	Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.	LPA PLG	2.93e-06	2	60	2	10854210
Pubmed	Gender affects skin wound healing in plasminogen deficient mice.	LPA PLG	2.93e-06	2	60	2	23527289
Pubmed	Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.	LPA PLG	2.93e-06	2	60	2	22079981
Pubmed	Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.	LPA PLG	2.93e-06	2	60	2	9490683
Pubmed	Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.	LPA PLG	2.93e-06	2	60	2	16481742
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.	LPA PLG	2.93e-06	2	60	2	18983515
Pubmed	Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.	LPA PLG	2.93e-06	2	60	2	34378815
Pubmed	Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.	LPA PLG	2.93e-06	2	60	2	11848464
Pubmed	Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.	LPA PLG	2.93e-06	2	60	2	7586361
Pubmed	Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.	LPA PLG	2.93e-06	2	60	2	21239499
Pubmed	Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	10642175
Pubmed	Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.	LPA PLG	2.93e-06	2	60	2	12225871
Pubmed	Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.	LPA PLG	2.93e-06	2	60	2	9770530
Pubmed	Plasminogen activation is required for the development of radiation-induced dermatitis.	LPA PLG	2.93e-06	2	60	2	30323258
Pubmed	Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.	LPA PLG	2.93e-06	2	60	2	37971174
Pubmed	The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.	LPA PLG	2.93e-06	2	60	2	9884337
Pubmed	Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.	LPA PLG	2.93e-06	2	60	2	26473342
Pubmed	Nonfibrinolytic functions of plasminogen.	LPA PLG	2.93e-06	2	60	2	10816371
Pubmed	Plasminogen is a critical regulator of cutaneous wound healing.	LPA PLG	2.93e-06	2	60	2	26791370
Pubmed	Selection of mutant µplasmin for amyloid-β cleavage in vivo.	LPA PLG	2.93e-06	2	60	2	32694536
Pubmed	Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.	LPA PLG	2.93e-06	2	60	2	7525077
Pubmed	Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.	LPA PLG	2.93e-06	2	60	2	16052596
Pubmed	Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	17122079
Pubmed	Role of plasminogen in propagation of scrapie.	LPA PLG	2.93e-06	2	60	2	16103174
Pubmed	Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.	LPA PLG	2.93e-06	2	60	2	21300353
Pubmed	Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.	LPA PLG	2.93e-06	2	60	2	15737740
Pubmed	Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.	LPA PLG	2.93e-06	2	60	2	11306011
Pubmed	Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.	LPA PLG	2.93e-06	2	60	2	12149246
Pubmed	Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.	LPA PLG	2.93e-06	2	60	2	22056679
Pubmed	Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.	LPA PLG	2.93e-06	2	60	2	18311818
Pubmed	Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.	LPA PLG	2.93e-06	2	60	2	21190118
Pubmed	The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.	LPA PLG	2.93e-06	2	60	2	18039665
Pubmed	Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	9671388
Pubmed	A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.	LPA PLG	2.93e-06	2	60	2	18997104
Pubmed	Growth and behavioral development in plasminogen gene-targeted mice.	LPA PLG	2.93e-06	2	60	2	10885855
Pubmed	Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARγ.	TREM2 CX3CL1	2.93e-06	2	60	2	25596843
Pubmed	Cellular density regulation of plasminogen gene expression in mouse hepatocytes.	LPA PLG	2.93e-06	2	60	2	12559391
Pubmed	Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.	LPA PLG	2.93e-06	2	60	2	27319402
Pubmed	Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.	LPA PLG	2.93e-06	2	60	2	15333838
Pubmed	Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.	LPA PLG	2.93e-06	2	60	2	16150044
Pubmed	Plasminogen has a broad extrahepatic distribution.	LPA PLG	2.93e-06	2	60	2	11916082
Pubmed	Unaltered prion protein cleavage in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	16543819
Pubmed	Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.	LPA PLG	2.93e-06	2	60	2	34423816
Pubmed	Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	11500461
Pubmed	Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.	LPA PLG	2.93e-06	2	60	2	12167431
Pubmed	Impaired wound healing in mice with a disrupted plasminogen gene.	LPA PLG	2.93e-06	2	60	2	8612226
Pubmed	Role of plasminogen activation in neuronal organization and survival.	LPA PLG	2.93e-06	2	60	2	19683575
Pubmed	Ovulation in plasminogen-deficient mice.	LPA PLG	2.93e-06	2	60	2	10537128
Pubmed	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.	LPA PLG	2.93e-06	2	60	2	23555246
Pubmed	Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.	LPA PLG	2.93e-06	2	60	2	18685433
Pubmed	Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.	LPA PLG	2.93e-06	2	60	2	31462325
Pubmed	Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.	LPA PLG	2.93e-06	2	60	2	9242524
Pubmed	Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.	LPA PLG	8.77e-06	3	60	2	16818777
Pubmed	Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.	LPA PLG	8.77e-06	3	60	2	19273908
Pubmed	Lactational competence and involution of the mouse mammary gland require plasminogen.	LPA PLG	8.77e-06	3	60	2	11003846
Pubmed	Plasmin and plasminogen induce macrophage reprogramming and regulate key steps of inflammation resolution via annexin A1.	LPA PLG	8.77e-06	3	60	2	28320709
Pubmed	Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.	LPA PLG	8.77e-06	3	60	2	12431907
Pubmed	Potentiation of TLR4 signalling by plasmin activity.	LPA PLG	8.77e-06	3	60	2	16413499
Pubmed	Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.	LPA PLG	8.77e-06	3	60	2	33827130
Pubmed	Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.	LPA PLG	8.77e-06	3	60	2	24612416
Pubmed	In vivo regulation of plasminogen function by plasma carboxypeptidase B.	LPA PLG	8.77e-06	3	60	2	12417566
Pubmed	Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins.	LPA PLG	8.77e-06	3	60	2	19465692
Pubmed	Alpha2-antiplasmin plays a significant role in acute pulmonary embolism.	LPA PLG	8.77e-06	3	60	2	12911586
Pubmed	Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.	LPA PLG	8.77e-06	3	60	2	31316511
Pubmed	Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation.	LPA PLG	8.77e-06	3	60	2	16949567
Pubmed	Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury.	LPA PLG	8.77e-06	3	60	2	11733368
Pubmed	Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.	LPA PLG	8.77e-06	3	60	2	9294211
Pubmed	Plasmin-dependent proteolysis of tissue factor pathway inhibitor in a mouse model of endotoxemia.	LPA PLG	8.77e-06	3	60	2	23106863
Pubmed	Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.	LPA PLG	8.77e-06	3	60	2	15630096
Cytoband	Ensembl 112 genes in cytogenetic band chr6q26	LPA PLG	1.99e-04	16	60	2	chr6q26
Cytoband	6q26	LPA PLG	2.54e-04	18	60	2	6q26
Cytoband	15q15.1	CCDC9B DISP2	1.75e-03	47	60	2	15q15.1
Cytoband	9q34.11	ZER1 LINC02913	2.22e-03	53	60	2	9q34.11
GeneFamily	Proteases, serine	TMPRSS2 TPSG1 PRSS36	2.44e-04	63	35	3	738
GeneFamily	Sulfatases	SULF2 GALNS	5.46e-04	18	35	2	410
GeneFamily	Ataxins\|Trinucleotide repeat containing	GIGYF2 TNRC6C	1.06e-03	25	35	2	775
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	NOL3 CARD10	1.53e-03	30	35	2	959
Coexpression	CTIP_DN.V1_DN	MAGEL2 TREM2 CARD10 BCAM CX3CL1	1.41e-05	134	60	5	M2751
Drug	orcinol	GPBAR1 GALNS TPSG1	1.10e-05	17	59	3	CID000010436
Drug	Thioproperazine dimesylate [2347-80-0]; Down 200; 6.2uM; MCF7; HT_HG-U133A	FLT4 TAF1C HPX TRIOBP ZNF205 OAS3	1.16e-05	196	59	6	2236_DN
Drug	Vancomycin hydrochloride [1404-93-9]; Up 200; 2.6uM; PC3; HT_HG-U133A	FLT4 TAF1C CSPG4 HPX CARD10 ADAMTS5	1.20e-05	197	59	6	4598_UP
Drug	Clopamide [636-54-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	SIPA1L3 HPX TMPRSS2 ZNF205 ZER1 BCAM	1.20e-05	197	59	6	5402_DN
Drug	Esculetin [305-01-1]; Up 200; 22.4uM; HL60; HT_HG-U133A	NOL3 SIPA1L3 ZER1 TPSG1 HHLA1 TESK1	1.20e-05	197	59	6	3120_UP
Drug	PF-01378883-00 [351320-41-7]; Down 200; 10uM; PC3; HT_HG-U133A	MTA2 SIPA1L3 HPX TMPRSS2 ZER1 CARD10	1.27e-05	199	59	6	6368_DN
Drug	Aminocaproic Acid	LPA PLG	1.98e-05	3	59	2	DB00513
Drug	E-10	MTA2 GALNS CSPG4	9.34e-05	34	59	3	CID006452259
Drug	ATN-2	MTA2 HPX	9.84e-05	6	59	2	CID003081684
Drug	borate	MTA2 GPBAR1 GALNS TMPRSS2	1.22e-04	98	59	4	CID000007628
Drug	Propofol [2078-54-8]; Down 200; 22.4uM; MCF7; HT_HG-U133A	SIPA1L3 ZNF205 ZER1 BCAM FUT4	1.37e-04	191	59	5	3386_DN
Drug	Clioquinol [130-26-7]; Up 200; 13uM; MCF7; HT_HG-U133A	PRUNE2 CSPG4 NUP98 TPSG1 ZZEF1	1.37e-04	191	59	5	6461_UP
Drug	Acacetin [480-44-4]; Down 200; 14uM; MCF7; HT_HG-U133A	TAF1C NUP98 OAS3 ZER1 PCTP	1.40e-04	192	59	5	6044_DN
Drug	Thiamine hydrochloride [67-03-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SIPA1L3 HPX TMPRSS2 OAS3 ZZEF1	1.44e-04	193	59	5	2894_DN
Drug	Estropipate [7280-37-7]; Down 200; 9.2uM; MCF7; HT_HG-U133A	SIPA1L3 TMPRSS2 ZNF205 ZER1 BCAM	1.47e-04	194	59	5	6068_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	HPX TMPRSS2 OAS3 ZER1 FUT4	1.47e-04	194	59	5	3354_DN
Drug	Betulinic acid [472-15-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A	HPX TMPRSS2 ZNF205 ADAMTS5 TPSG1	1.51e-04	195	59	5	4181_DN
Drug	Ethamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A	MTA2 SIPA1L3 HPX ZNF205 OAS3	1.51e-04	195	59	5	4399_DN
Drug	Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A	SIPA1L3 OAS3 ZER1 SSBP2 BCAM	1.54e-04	196	59	5	6028_DN
Drug	Piperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A	TAF1C HPX OAS3 ZER1 FUT4	1.54e-04	196	59	5	3420_UP
Drug	Catechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A	TAF1C TMPRSS2 ZNF205 ZER1 FUT4	1.54e-04	196	59	5	3351_DN
Drug	SB 203580; Down 200; 1uM; MCF7; HT_HG-U133A	MTA2 FLT4 SIPA1L3 TMPRSS2 ZNF205	1.54e-04	196	59	5	6899_DN
Drug	Yohimbine hydrochloride [65-19-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A	FLT4 TAF1C HPX TRIOBP ZNF205	1.54e-04	196	59	5	2755_DN
Drug	Terconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A	HPX TMPRSS2 ZNF205 FUT4 TPSG1	1.54e-04	196	59	5	4407_DN
Drug	Gabazine [105538-73-6]; Down 200; 10.8uM; PC3; HT_HG-U133A	MTA2 SIPA1L3 ZER1 BCAM ZZEF1	1.54e-04	196	59	5	4236_DN
Drug	Epitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A	FLT4 SIPA1L3 TMPRSS2 ZER1 BCAM	1.58e-04	197	59	5	7342_DN
Drug	Anabasine [494-52-0]; Up 200; 24.6uM; HL60; HT_HG-U133A	MISP NOL3 CSPG4 ZER1 SSBP2	1.58e-04	197	59	5	2512_UP
Drug	Sulfameter [651-06-9]; Up 200; 14.2uM; HL60; HT_HG-U133A	NOL3 SIPA1L3 TMPRSS2 ZER1 CARD10	1.58e-04	197	59	5	2712_UP
Drug	Solasodine [126-17-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	TMPRSS2 OAS3 ZER1 FUT4 ZZEF1	1.58e-04	197	59	5	3924_DN
Drug	Atropine sulfate monohydrate [5908-99-6]; Up 200; 5.8uM; MCF7; HT_HG-U133A	MTA2 PRUNE2 TAF1C TMPRSS2 ZER1	1.58e-04	197	59	5	2761_UP
Drug	Clebopride maleate [84370-95-6]; Down 200; 8.2uM; MCF7; HT_HG-U133A	SIPA1L3 HPX ZNF205 ZER1 BCAM	1.62e-04	198	59	5	5412_DN
Drug	Aceclofenac [89796-99-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	PRUNE2 SIPA1L3 CSPG4 HPX BCAM	1.62e-04	198	59	5	2281_UP
Drug	Chenodiol [474-25-9]; Up 200; 10.2uM; HL60; HT_HG-U133A	PRUNE2 NOL3 SIPA1L3 ZER1 SSBP2	1.62e-04	198	59	5	2402_UP
Drug	Nadide [53-84-9]; Up 200; 6uM; MCF7; HT_HG-U133A	FLT4 TAF1C SIPA1L3 FUT4 ZZEF1	1.62e-04	198	59	5	7227_UP
Drug	Bacitracin [1405-87-4]; Up 200; 2.8uM; HL60; HT_HG-U133A	NOL3 CSPG4 HPX ZER1 ZZEF1	1.62e-04	198	59	5	3109_UP
Drug	estradiol, USP; Up 200; 0.01uM; HL60; HT_HG-U133A	NOL3 TREM2 TRIOBP HHLA1 TESK1	1.62e-04	198	59	5	6200_UP
Drug	Nalidixic acid sodium salt hydrate; Down 200; 14.6uM; MCF7; HT_HG-U133A	SIPA1L3 TRIOBP TMPRSS2 OAS3 ZER1	1.66e-04	199	59	5	4691_DN
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A	FLT4 SIPA1L3 HPX BCAM FUT4	1.66e-04	199	59	5	2215_DN
Drug	Scopolamin-N-oxide hydrobromide [6106-81-6]; Up 200; 10uM; HL60; HG-U133A	MISP SIPA1L3 SSBP2 HOOK2 BCAM	1.66e-04	199	59	5	1415_UP
Drug	Mefenamic acid [61-68-7]; Up 200; 16.6uM; MCF7; HT_HG-U133A	SIPA1L3 TMPRSS2 ZER1 ADAMTS5 BCAM	1.66e-04	199	59	5	1699_UP
Drug	Suxibuzone [27470-51-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A	PRUNE2 TRIOBP ZER1 BCAM FUT4	1.66e-04	199	59	5	7163_UP
Drug	1,1-dimethylbiguanide hydrochloride; Down 200; 1000uM; MCF7; HG-U133A	CHERP HPX OAS3 ZZEF1 HHLA1	1.66e-04	199	59	5	4_DN
Drug	Bacitracin [1405-87-4]; Up 200; 2.8uM; MCF7; HT_HG-U133A	FLT4 TAF1C HPX ZER1 TESK1	1.69e-04	200	59	5	6488_UP
Drug	1,1-dimethylbiguanide hydrochloride; Down 200; 10uM; MCF7; HG-U133A	CHERP HPX TMPRSS2 SSBP2 HHLA1	1.69e-04	200	59	5	1_DN
Drug	monoacetin	GALNS LPA	1.83e-04	8	59	2	CID000033510
Drug	ganglioside GD2	CSPG4 FUT4 CX3CL1	2.03e-04	44	59	3	CID006450346
Disease	chronic kidney disease, APOL1 risk genotype carrier status	LPA PLG	3.78e-05	5	58	2	EFO_0003884, EFO_0009324
Disease	plasma plasminogen measurement	LPA PLG	3.78e-05	5	58	2	EFO_0006309
Disease	cholesteryl esters to total lipids in medium LDL percentage	LPA BCAM PLG	5.34e-05	37	58	3	EFO_0022252
Disease	angiostatin measurement	LPA PLG	5.67e-05	6	58	2	EFO_0008024
Disease	lipoprotein A measurement, apolipoprotein A 1 measurement	LPA PLG	7.92e-05	7	58	2	EFO_0004614, EFO_0006925
Disease	cholesterol to total lipids in small HDL percentage	LPA BCAM PLG	1.40e-04	51	58	3	EFO_0022240
Disease	free cholesterol to total lipids in small LDL percentage	LPA BCAM PLG	1.57e-04	53	58	3	EFO_0022286
Disease	cholesterol to total lipids in large LDL percentage	LPA BCAM PLG	1.86e-04	56	58	3	EFO_0022235
Disease	free cholesterol to total lipids in large HDL percentage	LPA BCAM PLG	1.86e-04	56	58	3	EFO_0022279
Disease	triglycerides to total lipids in small LDL percentage	LPA BCAM PLG	2.17e-04	59	58	3	EFO_0022337
Disease	free cholesterol in IDL measurement	LPA BCAM PLG	2.39e-04	61	58	3	EFO_0022181
Disease	free cholesterol in very large HDL measurement	LPA BCAM PLG	2.51e-04	62	58	3	EFO_0022273
Disease	triglycerides to total lipids in medium VLDL percentage	LPA BCAM PLG	2.63e-04	63	58	3	EFO_0022335
Disease	cholesterol to total lipids in very small VLDL percentage	LPA BCAM PLG	3.16e-04	67	58	3	EFO_0022245
Disease	asymmetric dimethylarginine measurement	SCP2D1-AS1 ZZEF1	3.40e-04	14	58	2	EFO_0010463
Disease	triglycerides to total lipids in very small VLDL percentage	LPA BCAM PLG	3.44e-04	69	58	3	EFO_0022341
Disease	rheumatoid arthritis (is_marker_for)	LPA ADAMTS5 CX3CL1	3.44e-04	69	58	3	DOID:7148 (is_marker_for)
Disease	phospholipids in large HDL measurement	SULF2 LPA PLG	4.07e-04	73	58	3	EFO_0022190
Disease	total lipids in large HDL	SULF2 LPA PLG	4.23e-04	74	58	3	EFO_0022189
Disease	free cholesterol to total lipids in small VLDL percentage	LPA BCAM PLG	4.40e-04	75	58	3	EFO_0022287
Disease	free cholesterol in large HDL measurement	SULF2 LPA PLG	5.13e-04	79	58	3	EFO_0022157
Disease	sleep duration, low density lipoprotein cholesterol measurement	LPA BCAM PLG	7.74e-04	91	58	3	EFO_0004611, EFO_0005271
Disease	Deep Vein Thrombosis	LPA PLG	7.78e-04	21	58	2	C0149871
Disease	Venous Thrombosis	LPA PLG	7.78e-04	21	58	2	C0042487
Disease	total cholesterol measurement, intermediate density lipoprotein measurement	LPA BCAM PLG	9.89e-04	99	58	3	EFO_0004574, EFO_0008595
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	LPA ZER1 PLG	9.89e-04	99	58	3	EFO_0004611, EFO_0007878
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	LPA ZER1 PLG	1.08e-03	102	58	3	EFO_0004329, EFO_0004611
Disease	free cholesterol measurement, intermediate density lipoprotein measurement	LPA BCAM PLG	1.14e-03	104	58	3	EFO_0008591, EFO_0008595
Disease	apolipoprotein A 1 measurement, apolipoprotein B measurement	SULF2 LPA BCAM	1.24e-03	107	58	3	EFO_0004614, EFO_0004615
Disease	lipoprotein A measurement	LPA BCAM PLG	1.41e-03	112	58	3	EFO_0006925

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPGWHNAPTLQSWEE	nan	26	Q6ZR03
GLGPWNRSEGWSRNH	MAMDC4	276	Q6UXC1
GLPCSWVQVPAHEWG	CARD10	981	Q9BWT7
LLHVWAGGPWPQGAT	CSPG4	2046	Q6UVK1
GSHTSQPQWVTGPWL	ADAMTS5	871	Q9UNA0
GGANWQPKVAPATWS	SNAP91	791	O60641
GQILWPCAHLPWDAG	DISP2	1121	A7MBM2
TRHGSQGPGQGTWWL	CECR2	231	Q9BXF3
HFWGPVANWGLPIAA	MPC1	26	Q9Y5U8
HTTQSAQWYAWGPPN	MTA2	371	O94776
ASWGGLDLPNNLANW	DRD5	186	P21918
LGPWEPHGSAWYNCN	ARIH1	376	Q9Y4X5
QVPHVWGWEVAGAPA	MISP	521	Q8IVT2
GWGPNWTLANSGEQL	NUP98	1146	P52948
HDWQGPRPWENLNLS	MAGEL2	906	Q9UJ55
LPALGWNHWTPGANC	GPBAR1	141	Q8TDU6
AVPGWASWPAHLALA	FUT4	46	P22083
EAWLQGISEDPGPNW	HOOK2	51	Q96ED9
SWPEGSKQQPLGWSN	CCDC9B	451	Q6ZUT6
HSPAWDGWNRPGLLT	TUBGCP6	851	Q96RT7
SNAQPGTWPWQVSLH	PRSS36	51	Q5K4E3
FDNPGGQIPSWLINW	PCTP	176	Q9UKL6
DHPWGTLNPSVSWGG	C6orf15	206	Q6UXA7
EGIWGINNQPPGTSW	C6orf15	236	Q6UXA7
PALAWWPGHVTAGQV	GALNS	321	P34059
WGSINTGPPNQWASD	GIGYF2	1046	Q6Y7W6
HCPPWNNSHEGMWGE	CHERP	451	Q8IWX8
HPGLWGQWACSEPSS	FAM25E	76	A8MYX2
VGGCVAHPHSWPWQV	LPA	1821	P08519
PWHPGLEQAAASWVG	LINC02913	136	Q8NAJ2
HVQFWVGSPSTPAGW	BCAM	266	P50895
TPEQGSPSLGQNWSW	SCP2D1-AS1	101	Q9BR46
QTWFSLFGWPEGPHS	CFAP47	1541	Q6ZTR5
WNPWRHGLSSVDSLP	PRRT3	916	Q5FWE3
SASWLPWHQENGPAG	FOCAD	1696	Q5VW36
PADPTWNVGHGSWEL	OAS3	701	Q9Y6K5
GWHSWPIAHQWPQGP	HPX	291	P02790
PGHWTQSTPWASALR	HHLA1	251	C9JL84
NITLGEPPGFLHSWW	SSBP2	51	P81877
WAAEHGAGPQAEGPW	TRMT44	571	Q8IYL2
GHAAPAGAWPWQASL	TPSG1	41	Q9NRR2
HWGDGQRSNPAWSAG	TNRC6C	581	Q9HCJ0
PPQTHARCSSWWGGL	PRUNE2	646	Q8WUY3
LQDLGGHQPWGCPWA	TAF1C	151	Q15572
GHQPWGCPWAYLSNR	TAF1C	156	Q15572
GVHLEDWPQQGAPWA	PPARGC1B	716	Q86YN6
YRSNAPWQWSGPASH	SIPA1L3	1076	O60292
PWQWSGPASHNSLPA	SIPA1L3	1081	O60292
QRTAGAPDPAWDWQH	NOL3	81	O60936
GPWHNTNSPWDSWAS	DIP2C-AS1	96	Q8N8Z3
CHWSAPELGQGSSPW	IL9R	66	Q01113
VVGGCVAHPHSWPWQ	PLG	581	P00747
PENWGGPAESSQSWH	TRIOBP	1516	Q9H2D6
AQQIWPGTWAPHIGN	ANKHD1	2521	Q8IWZ3
WAEGQFLPHGWSGVL	SLC7A14	241	Q8TBB6
PQGISPVSQHWATWA	ZER1	691	Q7Z7L7
PLNNPWHWTAFAGIL	TMPRSS2	301	O15393
EWAQQELGHTTPWSP	TICRR	476	Q7Z2Z1
CRGQHPLEWAWPGAQ	FLT4	51	P35916
PQGWAGEPWNRAQHS	TESK1	526	Q15569
SALWAAAWHGQKPGT	TREM2	191	Q9NZC2
AAGSPSGWEAPWVQQ	UNQ6494/PRO21346	56	Q6UXR6
GAQGAWGWAPLSHGS	ZNF205	66	O95201
WGPHQDWAAVSGTTP	ZZEF1	21	O43149
DNQHWQTAPFWTLGP	SULF2	731	Q8IWU5
TWQSSAPHQPGPSLW	CX3CL1	196	P78423