Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncell adhesion molecule binding

CDH23 FBLN1 CDHR5 NRXN3 CTNNB1 TJP3

1.23e-04599276GO:0050839
GeneOntologyMolecularFunctioncalcium ion binding

CDH23 FBLN1 CDHR5 FAT2 MMP13 FAT3

4.11e-04749276GO:0005509
GeneOntologyMolecularFunctionfibronectin binding

FBLN1 MMP13

1.20e-0338272GO:0001968
GeneOntologyCellularComponentbicellular tight junction

YBX3 CTNNB1 TJP3

5.63e-04131263GO:0005923
GeneOntologyCellularComponenttight junction

YBX3 CTNNB1 TJP3

6.69e-04139263GO:0070160
GeneOntologyCellularComponentcell-cell junction

YBX3 FAT2 CTNNB1 MMP13 TJP3

7.14e-04591265GO:0005911
GeneOntologyCellularComponentcatenin complex

CDH23 CTNNB1

7.21e-0432262GO:0016342
GeneOntologyCellularComponentapical junction complex

YBX3 CTNNB1 TJP3

9.69e-04158263GO:0043296
GeneOntologyCellularComponentmicrovillus membrane

CDHR5 CTNNB1

1.02e-0338262GO:0031528
HumanPhenoCentral adrenal insufficiency

CDH23 IARS2 CTNNB1

7.99e-0618123HP:0011734
HumanPhenoSudden loss of visual acuity

CDH23 CTNNB1

5.07e-055122HP:0001117
DomainCadherin_CS

CDH23 CDHR5 FAT2 FAT3

1.74e-05109274IPR020894
DomainCADHERIN_1

CDH23 CDHR5 FAT2 FAT3

2.00e-05113274PS00232
DomainCADHERIN_2

CDH23 CDHR5 FAT2 FAT3

2.07e-05114274PS50268
Domain-

CDH23 CDHR5 FAT2 FAT3

2.07e-051142742.60.40.60
DomainCA

CDH23 CDHR5 FAT2 FAT3

2.15e-05115274SM00112
DomainLAM_G_DOMAIN

FAT2 NRXN3 FAT3

2.20e-0538273PS50025
DomainCadherin-like

CDH23 CDHR5 FAT2 FAT3

2.22e-05116274IPR015919
DomainCadherin

CDH23 CDHR5 FAT2 FAT3

2.37e-05118274IPR002126
DomainLaminin_G_2

FAT2 NRXN3 FAT3

2.57e-0540273PF02210
DomainLamG

FAT2 NRXN3 FAT3

3.43e-0544273SM00282
DomainLaminin_G

FAT2 NRXN3 FAT3

7.88e-0558273IPR001791
Domain-

FAT2 NRXN3 FAT3

3.41e-04952732.60.120.200
DomainEGF_3

FBLN1 FAT2 NRXN3 FAT3

3.41e-04235274PS50026
DomainEGF

FBLN1 FAT2 NRXN3 FAT3

3.41e-04235274SM00181
DomainASX_HYDROXYL

FBLN1 NRXN3 FAT3

3.97e-04100273PS00010
DomainEGF-like_dom

FBLN1 FAT2 NRXN3 FAT3

4.25e-04249274IPR000742
DomainEGF_1

FBLN1 FAT2 NRXN3 FAT3

4.65e-04255274PS00022
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN1 NRXN3 FAT3

4.71e-04106273IPR000152
DomainEGF-like_CS

FBLN1 FAT2 NRXN3 FAT3

5.08e-04261274IPR013032
DomainEGF_2

FBLN1 FAT2 NRXN3 FAT3

5.38e-04265274PS01186
DomainCadherin

CDH23 FAT2 FAT3

5.67e-04113273PF00028
DomainEGF_CA

FBLN1 FAT2 FAT3

7.09e-04122273SM00179
DomainEGF-like_Ca-bd_dom

FBLN1 FAT2 FAT3

7.44e-04124273IPR001881
DomainConA-like_dom

FAT2 NRXN3 FAT3

3.78e-03219273IPR013320
DomainEGF_CA

FBLN1 FAT3

6.83e-0386272PF07645
Pubmed

Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.

YBX3 CTNNB1 TJP3

5.50e-072127318353970
Pubmed

Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes.

CDHR5 CTNNB1

5.80e-07227227310872
Pubmed

Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells.

CDHR5 CTNNB1

1.74e-06327222202456
Pubmed

Expression of CXCR4, MMP-13 and β-catenin in different histological subtypes of facial basal cell carcinoma.

CTNNB1 MMP13

1.74e-06327224398989
Pubmed

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.

FAT2 FAT3

1.74e-06327215744052
Pubmed

Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.

CTNNB1 MMP13

3.48e-06427228085114
Pubmed

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

CTNNB1 MMP13

3.48e-06427211953314
Pubmed

Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice.

CTNNB1 MMP13

5.80e-06527227122313
Pubmed

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

FAT2 FAT3

1.22e-05727216059920
Pubmed

Smad4 regulates growth plate matrix production and chondrocyte polarity.

CTNNB1 MMP13

1.22e-05727228167493
Pubmed

CCN1 Regulates Chondrocyte Maturation and Cartilage Development.

CTNNB1 MMP13

1.22e-05727226363286
Pubmed

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

ITM2C CTNNB1 FAT3

1.93e-056727321875946
Pubmed

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.

CDH23 CTNNB1

2.08e-05927218339676
Pubmed

RNF219/α-Catenin/LGALS3 Axis Promotes Hepatocellular Carcinoma Bone Metastasis and Associated Skeletal Complications.

CTNNB1 KMT2B

2.60e-051027233643786
Pubmed

SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes.

CTNNB1 MMP13

3.18e-051127228983104
Pubmed

JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.

CTNNB1 MMP13

3.18e-051127225587042
Pubmed

Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology.

CTNNB1 MEPE

3.81e-051227219389359
Pubmed

Hypomorphic and dominant-negative impact of truncated SOX9 dysregulates Hedgehog-Wnt signaling, causing campomelia.

CTNNB1 MMP13

4.50e-051327236584300
Pubmed

Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation.

CTNNB1 MMP13

5.25e-051427223567158
Pubmed

Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes.

CTNNB1 MMP13

5.25e-051427225432534
Pubmed

Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.

CTNNB1 MMP13

5.25e-051427230459452
Pubmed

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.

CKB ITM2C CTNNB1

5.34e-059427332062451
Pubmed

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis.

CTNNB1 INSR

6.06e-051527226369386
Pubmed

Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development.

CTNNB1 MMP13

6.06e-051527223188710
Pubmed

The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation.

CTNNB1 MMP13

6.92e-051627219557172
Pubmed

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.

CKB CAD CTNNB1

7.21e-0510427336055981
Pubmed

GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.

CTNNB1 TJP3

7.84e-051727229237740
Pubmed

Disruption of a Sox9-β-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II.

CTNNB1 MMP13

7.84e-051727222843502
Pubmed

Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.

FBLN1 MMP13

7.84e-051727227398409
Pubmed

Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.

FAT2 FAT3

8.81e-051827233108146
Pubmed

Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin.

CTNNB1 MMP13

8.81e-051827218052755
Pubmed

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis.

CTNNB1 MMP13

9.84e-051927215866164
Pubmed

Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development.

CKB CTNNB1

1.09e-042027225196998
Pubmed

Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice.

CTNNB1 MMP13

1.09e-042027229437042
Pubmed

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.

CTNNB1 MMP13

1.21e-042127234172578
Pubmed

Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis.

CTNNB1 MMP13

1.33e-042227219737917
Pubmed

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

CTNNB1 MEPE

2.01e-042727219801982
Pubmed

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis.

CTNNB1 MMP13

2.01e-042727227621061
Pubmed

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.

CKB YBX3

2.01e-042727230442762
Pubmed

Dose-dependent effects of Runx2 on bone development.

MMP13 MEPE

2.17e-042827219419310
Pubmed

HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis.

ABRA CTNNB1

2.33e-042927231201155
Pubmed

Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base.

CTNNB1 MMP13

2.49e-043027221911092
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

CKB YBX3 IARS2 CAD CTNNB1

3.55e-0480927532129710
Pubmed

Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.

CTNNB1 YY2

3.60e-043627232703236
Pubmed

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.

IARS2 CAD CTNNB1

3.76e-0418227330711629
Pubmed

Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.

FBLN1 MMP13

4.01e-043827218267097
Pubmed

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

DCBLD1 ITM2C CTNNB1 INSR

4.41e-0446727430194290
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

CKB CAD CTNNB1 INSR

5.04e-0448427431995728
Pubmed

Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis.

CDH23 CTNNB1

5.14e-044327232294451
Pubmed

Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

CKB YBX3

5.63e-044527223663784
Pubmed

The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis.

CTNNB1 INSR

6.14e-044727235733999
Pubmed

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

CTNNB1 INSR

6.14e-044727219167335
Pubmed

Substrate-trapping techniques in the identification of cellular PTP targets.

CTNNB1 INSR

6.67e-044927215588985
Pubmed

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

ARHGAP9 TJP3

6.95e-045027219807924
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CKB YBX3 IARS2 CAD UNC93B1 CTNNB1

6.98e-04144027630833792
InteractionRYK interactions

DCBLD1 ITM2C CTNNB1 FAT3 INSR

8.22e-06212275int:RYK
GeneFamilyCadherin related

CDH23 CDHR5 FAT2 FAT3

1.62e-091718424
CoexpressionACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP

MAML2 NRXN3 MMP13 FAT3

1.21e-05139274M6754
CoexpressionTRAVAGLINI_LUNG_NONCLASSICAL_MONOCYTE_CELL

CKB CDH23 UNC93B1 INSR

3.34e-05180274M41701
CoexpressionGSE33374_CD8_ALPHAALPHA_VS_ALPHABETA_CD161_HIGH_TCELL_DN

CKB ARHGAP9 ITM2C CAD

5.03e-05200274M8533
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CKB ARHGAP9 UNC93B1 RTL5

3.70e-06176274a85ad8b4815fde72edd5c900e882a0bc04033ea8
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-tDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBLN1 CDHR5 ITM2C UNC93B1

4.05e-061802743d9f3e6f13e558279b4ef43e2c44c7c50d761745
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDH23 CDHR5 ITM2C UNC93B1

4.05e-061802746a2366d76276452141db1bd93013a9503525f574
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDH23 CDHR5 ITM2C UNC93B1

4.81e-061882741f820cb19eb0e15f0eb69d07e457072bbdad8ecb
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DCBLD1 FBLN1 FAT3 MEPE

5.44e-06194274fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCelldistal-3-Hematologic-Plasmacytoid_Dendritic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CDH23 ARHGAP9 CDHR5 ITM2C

5.67e-061962746028b790abba9bad1d5373bab13eb24855988f48
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CDH23 ARHGAP9 CDHR5 ITM2C

5.78e-061972743a5908deb5c5a2bf06019a102fb1652233cf2a2a
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 ITM2C TJP3

5.90e-06198274efdbac7a3a02bff4ca48841772e0c136556c2b9b
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 ITM2C TJP3

5.90e-06198274a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCell3'-Adult-Distal_Rectal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C CTNNB1 INSR

5.90e-061982747ad7726fc405806b1d7824f58548073ea5e0c70b
ToppCell3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell-TA|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C CTNNB1 INSR

5.90e-061982741fbec311f2c987ca90a023a5989128c05aa12d5c
ToppCell5'-Adult-Distal_Rectal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB FBLN1 YBX3 ITM2C

5.90e-06198274db26c20321f9ab102d6484f22ddb2bde684067b1
ToppCell3'-Adult-Distal_Rectal-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C CTNNB1 INSR

5.90e-06198274ceede961ad9af6a3159db7efaa5087bf38aafc2d
ToppCell3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C CTNNB1 INSR

5.90e-061982744f26a60e99f42343e5af7221723e108a1a1b7827
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

CKB FBLN1 ITM2C FAT3

6.02e-061992745b9d355795dd03a22f0961dfd143425c367a4654
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 ITM2C TJP3

6.02e-0619927401d101b0fd5326947a9e5dddae6c2f93ab6e0a4d
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 ITM2C TJP3

6.02e-061992746d439c0c5e6b72fcb8d4dc72e7445eb6a01fe095
ToppCell3'-Adult-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 ITM2C TJP3

6.14e-06200274ce0c259f7fa4c0aa6d00e0bb362c029e96fce19e
ToppCell3'-Adult-LargeIntestine-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 ITM2C TJP3

6.14e-06200274156a949b3b59fb2b00e4f4a8933169f247a5f660
ToppCelldroplet-Fat-Scat-21m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB UNC93B1 RTL5

1.02e-0415127379827a76c675dcb82f59c0a45d0f962b02d5bfd6
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CDH23 CTNNB1 KMT2B

1.06e-04153273991782d111d66e25b40319d4e6dea40f2c2c0805
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB MAP3K15 KMT2B

1.24e-041612733f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCelldroplet-Kidney-nan-21m-Myeloid-CD45____macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB UNC93B1 MMP13

1.30e-04164273d4cdcd61e8c28b3fb912cef8837cc1a49678a729
ToppCelldroplet-Kidney-nan-21m-Myeloid-macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB UNC93B1 MMP13

1.33e-041652739852a4cb680af39c92c7d2d5e5fa8dc04e6602aa
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARHGAP9 CDHR5 ITM2C

1.33e-04165273e2a70dd5870fe8708bf630ed3e6eb3f295df0cdf
ToppCelldroplet-Kidney-nan-21m-Myeloid|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB UNC93B1 MMP13

1.33e-04165273c629ed33ff14834c32cc1a91116fb079f7aaa94d
ToppCelldroplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB UNC93B1 RTL5

1.35e-04166273c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

FBLN1 ITM2C FAT3

1.35e-0416627365dafed953b01a9830b54309af75c7a561e88336
ToppCellFetal_29-31_weeks-Epithelial-basal_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT2 NRXN3 MMP13

1.40e-041682736521bead9789d626b86cbd08692c621c5a5aef33
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.40e-0416827395416f352801ce42cc317565e7dfb00478c593e1
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP9 MAP3K15 FAT3

1.43e-04169273bca5322880c09b78ef10d9dda6420a80c1ba7e62
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|metastatic_Brain / Location, Cell class and cell subclass

CDH23 ITM2C UNC93B1

1.43e-0416927371f6761b9927f352e0ccc221ca373319915f4184
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB UNC93B1 RTL5

1.43e-04169273735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCellFetal_29-31_weeks-Epithelial-basal_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT2 NRXN3 MMP13

1.43e-04169273c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 TJP3

1.45e-04170273985c2d5962100fab0d95bee39f382ccbe799331e
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 MAP3K15 YY2

1.48e-04171273913bae728b5e653771a27c79a309eb023699f1d0
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 MAP3K15 YY2

1.48e-04171273f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell3'-Adult-Distal_Rectal-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C NRXN3

1.48e-041712730597339618fb4d416d55c538eceb353218a55002
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CKB UNC93B1 RTL5

1.48e-0417127338a05b5ec8ef8f09a2399994c6b4b9a707918ec1
ToppCell3'-Adult-Distal_Rectal-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C NRXN3

1.48e-041712730de81d12a8000f2c59cdb214e67dc526d18098fe
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITM2C FAT2 MMP13

1.50e-04172273bb542f6ca4eb8167129bc84ca1160a54fbb68731
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ARHGAP9 RTL5

1.50e-04172273cabe7b4131d72da87d3caacd8cced3a4f2cbef53
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITM2C FAT2 MMP13

1.50e-04172273aff37b9689b0d30ee7097d997d9588efc475c8fd
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.55e-04174273dc4298c1d9359f7e37454e9451f889017227d5cf
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

CDHR5 ITM2C UNC93B1

1.58e-0417527329fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCelldroplet-Liver-Npc-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.58e-0417527392a4a3fd323ee8360edd659f9e16dfddc8788e2f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 ARHGAP9 UNC93B1

1.61e-04176273d687e6c3f9043f2574d072f815b8c2258f9dc7b5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 ARHGAP9 UNC93B1

1.61e-041762734f37854124d77ee64dcb40fd491eaed2ba389891
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 ARHGAP9 UNC93B1

1.61e-041762730afba8707b847e5bdf6f38fe4379967631fe2240
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITM2C MAP3K15 NRXN3

1.63e-041772731dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCellfacs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ARHGAP9 RTL5

1.63e-041772737bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCelldroplet-Marrow-nan-21m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.63e-04177273b860013f1fd397400a62d66ab521cfc81349ffe2
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

CKB FBLN1 NRXN3

1.69e-04179273d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB NRXN3 FAT3

1.69e-04179273e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP9 FAT2 NRXN3

1.72e-041802736ac62bf1251978c8c12e715f7b73144fca619794
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C TJP3

1.72e-041802737c7c4d64ff99d0710a7d19d8bc29fc9217394db1
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.74e-04181273a93df1ba23d5b5f249491d69d12bfc0e274dafcf
ToppCellwk_20-22-Hematologic-Myeloid-pDC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CDH23 CDHR5 UNC93B1

1.74e-0418127360607c5ff6d5b1cb416adc034491dca31c41e988
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.77e-04182273aab96e856bb4cb4418a97b7b1aa06505cafb317a
ToppCellE18.5-samps-Mesenchymal-Myofibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

CKB FBLN1 NRXN3

1.80e-04183273de08f9ea02b7244d5a8788064631d10f06565337
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.80e-04183273c12a4603cf81b5736553a4530cea5cefab80556f
ToppCellMesenchymal_cells-Osteoblasts|Mesenchymal_cells / Lineage and Cell class

CKB DCBLD1 FAT3

1.80e-04183273d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MMP13 FAT3 MEPE

1.80e-0418327327a57cd8ea924420e182f3d72f5b29b00dea8fa0
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|World / Lineage, cell class and subclass

CDHR5 ITM2C UNC93B1

1.83e-0418427311619778bc773ecd1a9867330be04deaf324f31e
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKB ITM2C UNC93B1

1.83e-0418427394139bc2c880db3a791741ff7c5630cca52263a5
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

CDHR5 ITM2C UNC93B1

1.83e-041842732817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CKB FBLN1 NRXN3

1.86e-04185273427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellPBMC-Control-cDC_10|Control / Compartment, Disease Groups and Clusters

CKB FAT2 TJP3

1.86e-041852734b5a7450fed912f340da16065c1e65d626dbe8d1
ToppCellControl-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

FBLN1 FAT2 MMP13

1.86e-04185273d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

YBX3 CTNNB1 INSR

1.86e-04185273673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell5'-Adult-Distal_Rectal-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C GAS2L2

1.89e-041862734046b701aa29712d9f7c774f8955215122c3c003
ToppCellNS-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CKB YBX3 FAT2

1.89e-04186273c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCell5'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB ITM2C GAS2L2

1.89e-04186273bd5837033c1ffcbe5dd30195cc4846a2ba351bcd
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 TJP3

1.92e-041872731909b65ba23d598e396f77eecae562bb59bf5d5d
ToppCellMesenchymal_cells-Ng2+_MSCs|Mesenchymal_cells / Lineage and Cell class

CTNNB1 MMP13 MEPE

1.92e-04187273e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCellLAM-Lymphoid-pDC|Lymphoid / Condition, Lineage and Cell class

CDH23 ITM2C UNC93B1

1.92e-041872734d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 TJP3

1.98e-041892738478f433495dabe813146a1f6b00098db8ce775a
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDH23 ITM2C UNC93B1

2.01e-04190273c44aae2e0d3cc84a187e12917fd8c2d7483f41d8
ToppCellIPF-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

FBLN1 FAT2 MMP13

2.01e-041902734f15842b424eefadbfe451875e517cf70e29607f
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDH23 ITM2C UNC93B1

2.01e-04190273705489ebbaf3d8e643498c3e507742114475fc55
ToppCellmyeloid-pDC|World / Lineage and Cell class

CDH23 ITM2C UNC93B1

2.01e-0419027388c42779ce2f817d28e672d83f3f1158581edf73
ToppCell10x3'2.3-week_17-19-Myeloid_DC-DC-pDC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CDH23 ITM2C UNC93B1

2.04e-04191273faf4de97003a938a243b0101456913c2b0e1804f
ToppCellBasal_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

FBLN1 FAT2 MMP13

2.04e-04191273a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCellInfluenza_Severe-Non-classical_Monocyte|Influenza_Severe / Disease group and Cell class

CKB CDH23 TMC6

2.04e-04191273197edf6feb1cfc71d88e532d74f77305a42a3486
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB NRXN3 FAT3

2.04e-04191273de2cd94ee88a7754f86d39469e38374d668210c7
ToppCellCOVID-19_Moderate-pDC|COVID-19_Moderate / disease group, cell group and cell class

CDH23 ITM2C UNC93B1

2.04e-041912739d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCell(1)_Osterolineage_cells-(10)_OLC-1|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

CTNNB1 MMP13 FAT3

2.04e-0419127378ad7c555409ce1391bce406bc0f3ef575329ece
ToppCell(7)_Epithelial_cells-(7)_Epithelial-H_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

FBLN1 FAT2 MMP13

2.08e-041922737a6dd2ae217b8f8e460d47ad128904408299458c
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 TJP3

2.08e-041922739f7e0d610741288d0779bd7c02852c791431e4ea
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CKB FBLN1 NRXN3

2.08e-0419227393903576dddd8227328e4ced75aa7625eedb9baf
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CKB CDH23 UNC93B1

2.08e-041922737bcdbd97fa8c3bfccde426d44979601226913fc3
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 TJP3

2.11e-0419327332eb026d4317c1499d51294d396dfd5f293f9deb
ToppCellnormal-na-Myeloid-non-classical_monocyte-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

CKB CDH23 UNC93B1

2.11e-04193273053adc7ed9f997b503e12239a684bb9f5896e10c
ToppCellControl-CD8+_T_naive|Control / Disease condition and Cell class

YBX3 ITM2C MAML2

2.11e-04193273627d345baf1940218c61907305705298e473dbab
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CKB FBLN1 NRXN3

2.11e-04193273cfab88935abe0a15632c5eec8ff00a857ec9b3ed
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

YBX3 CTNNB1 INSR

2.11e-04193273479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 TJP3

2.11e-04193273930df79b0600f43617052313294be33bcf5631f0
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CDH23 FBLN1 FAT3

2.14e-04194273e93de9428c986b8943fc169258847c650cfab0e5
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CKB CDHR5 TJP3

2.14e-0419427307d8e38cbc2c7f0564c14f7c365f345f901b73b2
ToppCellmedial-Hematologic-Plasmacytoid_Dendritic|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CDHR5 ITM2C UNC93B1

2.14e-04194273bb36274d6fe2d18c545a17d3809f331586502d01
DiseaseSquamous cell carcinoma of esophagus

FAT2 CTNNB1 FAT3

7.97e-0595263C0279626
Diseasemedial orbital frontal cortex volume measurement

FAT2 NRXN3

2.21e-0425262EFO_0010315
DiseaseLeft Ventricular Hypertrophy

CKB CTNNB1

2.21e-0425262C0149721
Diseaseprostate cancer (is_marker_for)

CTNNB1 KMT2B MMP13

3.45e-04156263DOID:10283 (is_marker_for)
Diseaseretinal detachment, retinal break

ARHGAP9 FAT3

4.36e-0435262EFO_0005773, EFO_0010698
Diseasenasal disorder

NRXN3 GAS2L2

4.36e-0435262MONDO_0002436
Diseaserenal cell carcinoma

MAML2 INSR

6.29e-0442262EFO_0000681
DiseaseGastric Adenocarcinoma

CTNNB1 INSR

7.22e-0445262C0278701
DiseaseCardiomyopathy, Dilated

ABRA CTNNB1

8.21e-0448262C0007193
Diseasehepatocellular carcinoma (implicated_via_orthology)

CAD INSR

8.56e-0449262DOID:684 (implicated_via_orthology)
DiseaseCardiomyopathy, Familial Idiopathic

ABRA CTNNB1

8.91e-0450262C1449563
DiseaseAlzheimer's disease (biomarker_via_orthology)

CTNNB1 INSR

1.20e-0358262DOID:10652 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PGPIYAEDGDRGINQ

CDHR5

271

Q9HBB8
RDYEGPFEVTEGQPG

CDH23

1746

Q9H251
GAQGEPLGYRQDDPS

CTNNB1

701

P35222
PGYNEIPEREENGGN

MEPE

301

Q9NQ76
NPDNLQGGDDLDPNY

CKB

111

P12277
GQGQPRVPPNYEGSD

FAT2

4321

Q9NYQ8
GIQSLYGPGDEDPNP

MMP13

261

P45452
DGEGQSGELQPQRPY

NRXN3

126

Q9Y4C0
RYHQQGEGQEEPPLN

KMT2B

2491

Q9UMN6
DGGYLDQPDNCPERV

INSR

1251

P06213
YERINVPVPQFGGGD

ITM2C

126

Q9NQX7
ENIFPNRYGDDPGEQ

MAML2

286

Q8IZL2
QEDPYLNDRCRGGGP

FBLN1

171

P23142
QEQEGRYTPLPLGGN

GAS2L2

581

Q8NHY3
GDGRNVYQEVGPPQV

FAT3

4216

Q8TDW7
PVAGVGAQDGDYQRP

DCBLD1

641

Q8N8Z6
EEGYPPATGPGQEAQ

MAP3K15

1156

Q6ZN16
GEPQQDPGTEETYGE

RTL5

436

Q5HYW3
EVGGPDALEYVPGQD

IARS2

581

Q9NSE4
YERDAGVLEPGQPEN

ABRA

131

Q8N0Z2
RPCPYEQAQGGDGPE

UNC93B1

581

Q9H1C4
RGPPRNYAGEEEEEG

YBX3

186

P16989
QGAVGEGQAENPPDY

YY2

196

O15391
SDGRYVFPEQPGQEG

ARHGAP9

601

Q9BRR9
DGQVLVPPGYGQDVR

CAD

1796

P27708
DGPQRVEEVDQGRGY

TJP3

116

O95049
GDQGQGPSPYDESEV

TMC6

16

Q7Z403