Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

GIPC1 AGAP5 GAPVD1 RAPGEF6 SBF1 DOCK9 LRRK2 AGAP7P RAPGEF2 AGAP4 AGAP6 TBC1D26

2.84e-075077312GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

GIPC1 AGAP5 GAPVD1 RAPGEF6 SBF1 DOCK9 LRRK2 AGAP7P RAPGEF2 AGAP4 AGAP6 TBC1D26

2.84e-075077312GO:0030695
GeneOntologyMolecularFunctionGTPase activator activity

GIPC1 AGAP5 GAPVD1 LRRK2 AGAP7P RAPGEF2 AGAP4 AGAP6 TBC1D26

7.93e-07279739GO:0005096
GeneOntologyMolecularFunctionrRNA (cytosine-N4-)-methyltransferase activity

METTL15P1 METTL15

1.32e-052732GO:0071424
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

AGAP5 LONP1 ABCA4 LRRK2 EIF5B RASL12 IDE AGAP7P TOR3A ATP13A2 AGAP4 AGAP6

2.24e-057757312GO:0017111
GeneOntologyMolecularFunctionguanyl ribonucleotide binding

AGAP5 INSR LRRK2 EIF5B RASL12 AGAP7P RAPGEF2 AGAP4 AGAP6

3.09e-05439739GO:0032561
GeneOntologyMolecularFunctionguanyl nucleotide binding

AGAP5 INSR LRRK2 EIF5B RASL12 AGAP7P RAPGEF2 AGAP4 AGAP6

3.09e-05439739GO:0019001
GeneOntologyMolecularFunctionGTPase activity

AGAP5 ABCA4 LRRK2 EIF5B RASL12 AGAP7P AGAP4 AGAP6

3.41e-05341738GO:0003924
GeneOntologyMolecularFunctionpyrophosphatase activity

AGAP5 LONP1 ABCA4 LRRK2 EIF5B RASL12 IDE AGAP7P TOR3A ATP13A2 AGAP4 AGAP6

4.86e-058397312GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

AGAP5 LONP1 ABCA4 LRRK2 EIF5B RASL12 IDE AGAP7P TOR3A ATP13A2 AGAP4 AGAP6

4.91e-058407312GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

AGAP5 LONP1 ABCA4 LRRK2 EIF5B RASL12 IDE AGAP7P TOR3A ATP13A2 AGAP4 AGAP6

4.91e-058407312GO:0016818
GeneOntologyMolecularFunctionzinc ion transmembrane transporter activity

SLC39A6 SLC39A7 SLC39A13

8.98e-0524733GO:0005385
GeneOntologyMolecularFunctionphosphatidic acid binding

RAPGEF6 RAPGEF2 ATP13A2

8.98e-0524733GO:0070300
GeneOntologyMolecularFunctionGTP binding

AGAP5 INSR LRRK2 EIF5B RASL12 AGAP7P AGAP4 AGAP6

9.90e-05397738GO:0005525
GeneOntologyMolecularFunctioninsulin binding

INSR IDE

1.31e-045732GO:0043559
GeneOntologyMolecularFunctionphospholipid binding

AGAP5 RAPGEF6 AGAP7P RAPGEF2 ATP13A2 AGAP4 AGAP6 VPS13B ITPR3

1.68e-04548739GO:0005543
GeneOntologyMolecularFunctionrRNA (cytosine) methyltransferase activity

METTL15P1 METTL15

1.96e-046732GO:0016434
GeneOntologyMolecularFunctionlipid binding

AGAP5 RAPGEF6 ABCA4 INSR AGAP7P RAPGEF2 ATP13A2 AGAP4 AGAP6 VPS13B VDR ITPR3

2.27e-049887312GO:0008289
GeneOntologyMolecularFunctiontransition metal ion transmembrane transporter activity

SLC39A6 SLC39A7 SLC39A13

5.57e-0444733GO:0046915
GeneOntologyMolecularFunctionenzyme activator activity

GIPC1 AGAP5 GAPVD1 LRRK2 AGAP7P RAPGEF2 AGAP4 AGAP6 TBC1D26

6.28e-04656739GO:0008047
GeneOntologyMolecularFunctionmonoatomic cation:bicarbonate symporter activity

SLC4A8 SLC39A6

1.00e-0313732GO:0140410
GeneOntologyMolecularFunctioninsulin receptor substrate binding

LONP1 INSR

1.34e-0315732GO:0043560
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

GAPVD1 RAPGEF6 SBF1 DOCK9 RAPGEF2

1.57e-03231735GO:0005085
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC4A8 TPTE2 NIPAL1 SLC39A6 TCIRG1 ATP13A2 SLC39A7 SLC39A13 ITPR3

2.34e-03793739GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC4A8 NIPAL1 SLC39A6 TCIRG1 ATP13A2 SLC39A7 SLC39A13 ITPR3

2.87e-03664738GO:0008324
GeneOntologyMolecularFunctionrRNA methyltransferase activity

METTL15P1 METTL15

3.45e-0324732GO:0008649
GeneOntologyMolecularFunctioncatalytic activity, acting on a rRNA

METTL15P1 METTL15

3.75e-0325732GO:0140102
GeneOntologyMolecularFunctionMAP kinase kinase kinase activity

LRRK2 ARAF

4.36e-0327732GO:0004709
GeneOntologyBiologicalProcessregulation of GTPase activity

AGAP5 GAPVD1 RAPGEF6 DOCK9 LRRK2 AGAP7P RAPGEF2 AGAP4 AGAP6 TBC1D26

1.87e-073357010GO:0043087
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

AGAP5 RAPGEF6 DOCK9 AGAP7P RAPGEF2 AGAP4 AGAP6 TBC1D26

1.72e-06244708GO:0043547
GeneOntologyBiologicalProcessintracellular zinc ion homeostasis

SLC39A6 ATP13A2 SLC39A7 SLC39A13

1.49e-0544704GO:0006882
GeneOntologyBiologicalProcessactivation of GTPase activity

AGAP5 AGAP7P AGAP4 AGAP6 TBC1D26

3.46e-05109705GO:0090630
GeneOntologyBiologicalProcesszinc ion transmembrane transport

SLC39A6 SLC39A7 SLC39A13

1.28e-0429703GO:0071577
GeneOntologyBiologicalProcesszinc ion transport

SLC39A6 SLC39A7 SLC39A13

1.42e-0430703GO:0006829
GeneOntologyBiologicalProcessregulation of hydrolase activity

AGAP5 GAPVD1 RAPGEF6 DOCK9 LRRK2 AGAP7P RAPGEF2 ATP13A2 AGAP4 AGAP6 TBC1D26

1.70e-048787011GO:0051336
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

SLC4A8 LRRK2 SLC39A6 TCIRG1 ATP13A2 SLC39A7 SLC39A13 VDR ITPR3

2.15e-04611709GO:0030003
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

SLC4A8 LRRK2 SLC39A6 TCIRG1 ATP13A2 SLC39A7 SLC39A13 VDR ITPR3

2.46e-04622709GO:0006873
GeneOntologyBiologicalProcessembryonic forelimb morphogenesis

RPGRIP1L RDH10 NIPBL

2.68e-0437703GO:0035115
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

AGAP5 RAPGEF6 DOCK9 AGAP7P RAPGEF2 AGAP4 AGAP6 TBC1D26

2.81e-04499708GO:0051345
MousePhenoabnormal tooth morphology

SMG1 AGAP5 RPGRIP1L ATR TCIRG1 IDE AGAP7P AGAP4 AGAP6 SLC39A13

1.41e-063186310MP:0002100
MousePhenoabnormal dental arch morphology

SMG1 AGAP5 RPGRIP1L ATR TCIRG1 IDE AGAP7P AGAP4 AGAP6 SLC39A13

1.46e-063196310MP:0030254
MousePhenofused cornea and lens

AGAP5 AGAP7P AGAP4 AGAP6

3.72e-0624634MP:0001307
MousePhenoabnormal brain commissure morphology

RPGRIP1L ATR MAST1 MAGEE2 THOC2 NIPBL ITPR3

7.60e-06161637MP:0002199
MousePhenoabsent corpus callosum

RPGRIP1L ATR NIPBL ITPR3

1.39e-0533634MP:0002196
MousePhenoabnormal nervous system tract morphology

RPGRIP1L ATR MAST1 MAGEE2 THOC2 NIPBL ITPR3

2.16e-05189637MP:0000778
MousePhenoabnormal corpus callosum morphology

RPGRIP1L ATR MAST1 THOC2 NIPBL ITPR3

2.43e-05129636MP:0000780
MousePhenoabnormal dorsal telencephalic commissure morphology

RPGRIP1L ATR MAST1 THOC2 NIPBL ITPR3

2.76e-05132636MP:0008219
MousePhenoabnormal brain white matter morphology

RPGRIP1L ATR MAST1 MAGEE2 THOC2 NIPBL ITPR3

3.75e-05206637MP:0008026
MousePhenoabnormal facial morphology

SMG1 AGAP5 RPGRIP1L ATR RDH10 TCIRG1 IDE AGAP7P THOC2 AGAP4 AGAP6 NIPBL SLC39A13 VDR

4.13e-059106314MP:0003743
MousePhenoabnormal skin morphology

AGAP5 GAPVD1 CASTOR1 ATR BMP10 MPZL3 FAT3 SYNE2 RTTN AGAP7P RAPGEF2 AGAP4 DDB1 AGAP6 VPS13B SLC39A13 VDR ITPR3

4.93e-0514556318MP:0002060
MousePhenoabnormal viscerocranium morphology

SMG1 AGAP5 RPGRIP1L ATR TCIRG1 IDE AGAP7P AGAP4 AGAP6 NIPBL SLC39A13

6.03e-055936311MP:0005274
MousePhenoabnormal corpus callosum size

RPGRIP1L MAST1 THOC2 NIPBL

8.62e-0552634MP:0020573
MousePhenosmall heart

GIPC1 GAPVD1 BMP10 RTTN THOC2 DAGLA NIPBL VPS13B

9.15e-05321638MP:0002188
MousePhenoabnormal head morphology

SMG1 AGAP5 RPGRIP1L ATR RDH10 TCIRG1 MAGEE2 IDE AGAP7P THOC2 AGAP4 AGAP6 NIPBL SLC39A13 VDR

1.02e-0411206315MP:0000432
MousePhenolipofuscinosis

ABCA4 LRRK2 ATP13A2

1.09e-0421633MP:0008842
MousePhenoabnormal jaw morphology

SMG1 AGAP5 RPGRIP1L ATR TCIRG1 IDE AGAP7P AGAP4 AGAP6 SLC39A13

1.18e-045306310MP:0000454
MousePhenoabnormal snout morphology

AGAP5 AGAP7P THOC2 AGAP4 AGAP6 NIPBL VDR

1.50e-04257637MP:0000443
MousePhenoincreased circulating potassium level

AGAP5 ABHD8 AGAP7P AGAP4 AGAP6

2.11e-04121635MP:0005627
MousePhenoabnormal cornea morphology

AGAP5 RDH10 AGAP7P TRRAP AGAP4 AGAP6 SLC39A13 ITPR3

2.25e-04366638MP:0001312
MousePhenoabnormal cranium morphology

SMG1 AGAP5 RPGRIP1L ATR TCIRG1 IDE AGAP7P AGAP4 AGAP6 NIPBL PHIP SLC39A13

2.36e-048136312MP:0000438
MousePhenoabnormal potassium level

AGAP5 ABHD8 AGAP7P AGAP4 AGAP6 VDR

2.46e-04196636MP:0020887
MousePhenoabnormal potassium ion homeostasis

AGAP5 ABHD8 AGAP7P AGAP4 AGAP6 VDR

2.60e-04198636MP:0011978
MousePhenoabnormal craniofacial bone morphology

SMG1 AGAP5 RPGRIP1L ATR TCIRG1 IDE AGAP7P AGAP4 AGAP6 NIPBL PHIP SLC39A13

2.76e-048276312MP:0002116
MousePhenodilated hair follicle

MPZL3 VDR

4.14e-047632MP:0010699
MousePhenoabnormal lens development

AGAP5 AGAP7P AGAP4 AGAP6

4.16e-0478634MP:0005545
MousePhenoabnormal liver morphology

SMG1 GAPVD1 RPGRIP1L SBF1 ATR MED16 MPZL3 RTTN INSR RDH10 RAPGEF2 THOC2 RUNDC1 DAGLA PHIP VPS13B

4.71e-0414336316MP:0000598
MousePhenoabnormal mitochondrial chromosome morphology

LONP1 METTL15P1 METTL15

4.73e-0434633MP:0011638
MousePhenoimpaired learning

METTL15P1 THOC2 METTL15 VPS13B ITPR3

5.01e-04146635MP:0012315
MousePhenoabnormal axial skeleton morphology

SMG1 AGAP5 ABCA4 RPGRIP1L ATR MPZL3 TPTE2 TCIRG1 IDE AGAP7P RUNDC1 AGAP4 AGAP6 NIPBL PHIP SLC39A13

5.71e-0414586316MP:0002114
MousePhenoabnormal fat-soluble vitamin level

ABCA4 TCIRG1 VDR

6.08e-0437633MP:0005401
MousePhenoabnormal heart size

GIPC1 GAPVD1 ATR BMP10 FAT3 RTTN TCIRG1 IDE NAA38 THOC2 DAGLA NIPBL VPS13B VDR

6.33e-0411806314MP:0005406
MousePhenoabnormal hepatobiliary system morphology

SMG1 GAPVD1 RPGRIP1L SBF1 ATR MED16 MPZL3 RTTN INSR RDH10 RAPGEF2 THOC2 RUNDC1 DAGLA PHIP VPS13B

6.53e-0414766316MP:0002138
MousePhenoabsent pinna reflex

AGAP5 AGAP7P AGAP4 AGAP6

6.87e-0489634MP:0006358
MousePhenorickets

TCIRG1 VDR

7.05e-049632MP:0003116
MousePhenoabnormal long bone metaphysis morphology

TCIRG1 SLC39A13 VDR

7.10e-0439633MP:0000133
MousePhenocornea opacity

AGAP5 AGAP7P AGAP4 AGAP6 ITPR3

7.38e-04159635MP:0001314
MousePhenoincreased mineral level

AGAP5 MPZL3 TCIRG1 ABHD8 AGAP7P LRP1B AGAP4 AGAP6 BBS10 VDR

7.48e-046686310MP:0014535
MousePhenoabnormal body length

SMG1 SBF1 ATR MPZL3 ABHD8 DAGLA PHIP VPS13B ITPR3

7.52e-04550639MP:0001256
MousePhenoabnormal mouth morphology

SMG1 AGAP5 RPGRIP1L ATR TCIRG1 IDE AGAP7P AGAP4 AGAP6 SLC39A13

7.65e-046706310MP:0000452
MousePhenoabnormal mineral level

AGAP5 LONP1 MPZL3 TCIRG1 ABHD8 AGAP7P DSEL TRRAP LRP1B AGAP4 AGAP6 BBS10 VDR

7.93e-0410666313MP:0000192
MousePhenoabnormal mineral homeostasis

AGAP5 LONP1 MPZL3 TCIRG1 ABHD8 AGAP7P DSEL TRRAP LRP1B AGAP4 AGAP6 BBS10 VDR

8.65e-0410766313MP:0005636
MousePhenonervous system inclusion bodies

LRRK2 IDE ATP13A2

8.84e-0442633MP:0014062
MousePhenoabnormal thymus size

ATR BMP10 FAT3 TCIRG1 NAA38 DDB1 DAGLA ARAF VDR

8.99e-04564639MP:0002364
MousePhenoabnormal craniofacial morphology

SMG1 AGAP5 RPGRIP1L ATR RDH10 TCIRG1 IDE AGAP7P THOC2 AGAP4 AGAP6 NIPBL PHIP SLC39A13 VDR

9.19e-0413726315MP:0000428
MousePhenocraniofacial phenotype

SMG1 AGAP5 RPGRIP1L ATR RDH10 TCIRG1 IDE AGAP7P THOC2 AGAP4 AGAP6 NIPBL PHIP SLC39A13 VDR

9.19e-0413726315MP:0005382
MousePhenoabnormal circulating potassium level

AGAP5 ABHD8 AGAP7P AGAP4 AGAP6

1.02e-03171635MP:0002668
MousePhenoabnormal pinna reflex

AGAP5 AGAP7P AGAP4 AGAP6

1.10e-03101634MP:0001485
MousePhenodecreased corpus callosum size

RPGRIP1L THOC2 NIPBL

1.23e-0347633MP:0000781
MousePhenodecreased bone mineral density of femur

MPZL3 SLC39A13 VDR

1.23e-0347633MP:0020010
MousePhenoabnormal circulating mineral level

AGAP5 LONP1 MPZL3 TCIRG1 ABHD8 AGAP7P TRRAP LRP1B AGAP4 AGAP6 BBS10 VDR

1.28e-039826312MP:0006357
MousePhenoincreased mitochondrial DNA content

METTL15P1 METTL15

1.28e-0312632MP:0030937
MousePhenoabnormal skin coloration

AGAP5 MPZL3 AGAP7P AGAP4 AGAP6

1.35e-03182635MP:0011239
MousePhenoabnormal cerebral hemisphere morphology

RPGRIP1L ATR LRRK2 RDH10 MAST1 MAGEE2 THOC2 NIPBL ITPR3

1.37e-03599639MP:0008540
DomainFAT

SMG1 ATR TRRAP

1.23e-066753PS51189
DomainFATC

SMG1 ATR TRRAP

1.23e-066753PS51190
DomainFATC_dom

SMG1 ATR TRRAP

1.23e-066753IPR003152
DomainPIK_FAT

SMG1 ATR TRRAP

1.23e-066753IPR014009
DomainFATC

SMG1 ATR TRRAP

1.23e-066753SM01343
DomainArfGap

AGAP5 AGAP7P AGAP4 AGAP6

5.28e-0629754SM00105
DomainArfGap

AGAP5 AGAP7P AGAP4 AGAP6

5.28e-0629754PF01412
DomainARFGAP

AGAP5 AGAP7P AGAP4 AGAP6

5.28e-0629754PS50115
DomainArfGAP

AGAP5 AGAP7P AGAP4 AGAP6

5.28e-0629754IPR001164
DomainARM-type_fold

SMG1 RELCH ATR COPB1 DOCK9 RTTN LRRK2 TRRAP NIPBL

8.42e-06339759IPR016024
DomainARM-like

SMG1 RELCH ATR COPB1 RTTN LRRK2 TRRAP NIPBL

1.26e-05270758IPR011989
DomainZip

SLC39A6 SLC39A7 SLC39A13

2.19e-0514753PF02535
DomainZIP

SLC39A6 SLC39A7 SLC39A13

2.19e-0514753IPR003689
Domain-

RELCH ATR COPB1 RTTN LRRK2 TRRAP NIPBL

3.05e-052227571.25.10.10
Domain-

SMG1 ATR TRRAP

3.35e-05167531.10.1070.11
DomainPI3Kc

SMG1 ATR TRRAP

3.35e-0516753SM00146
DomainPI3/4_kinase_cat_dom

SMG1 ATR TRRAP

4.86e-0518753IPR000403
DomainPI3_PI4_kinase

SMG1 ATR TRRAP

4.86e-0518753PF00454
DomainPI3_4_KINASE_3

SMG1 ATR TRRAP

4.86e-0518753PS50290
DomainPI3_4_KINASE_1

SMG1 ATR TRRAP

4.86e-0518753PS00915
DomainPI3_4_KINASE_2

SMG1 ATR TRRAP

4.86e-0518753PS00916
DomainFATC

SMG1 ATR

1.58e-045752PF02260
DomainHEAT_REPEAT

SMG1 RELCH ATR NIPBL

1.80e-0470754PS50077
DomainFAT

ATR TRRAP

2.36e-046752PF02259
DomainPIK-rel_kinase_FAT

ATR TRRAP

2.36e-046752IPR003151
DomainPDZ

GIPC1 PTPN13 RAPGEF6 MAST1 RAPGEF2

2.58e-04141755PF00595
DomainPDZ

GIPC1 PTPN13 RAPGEF6 MAST1 RAPGEF2

3.23e-04148755SM00228
Domain-

GIPC1 PTPN13 RAPGEF6 MAST1 RAPGEF2

3.43e-041507552.30.42.10
DomainPDZ

GIPC1 PTPN13 RAPGEF6 MAST1 RAPGEF2

3.54e-04151755PS50106
DomainPDZ

GIPC1 PTPN13 RAPGEF6 MAST1 RAPGEF2

3.65e-04152755IPR001478
DomainPH

AGAP5 SBF1 DOCK9 AGAP7P AGAP4 AGAP6

8.78e-04278756SM00233
DomainPH_DOMAIN

AGAP5 SBF1 DOCK9 AGAP7P AGAP4 AGAP6

8.95e-04279756PS50003
DomainPH_domain

AGAP5 SBF1 DOCK9 AGAP7P AGAP4 AGAP6

9.11e-04280756IPR001849
DomainKinase-like_dom

SMG1 PTPN13 ATR INSR LRRK2 MAST1 TRRAP ARAF

1.46e-03542758IPR011009
DomainPH_dom-like

AGAP5 PTPN13 SBF1 DOCK9 AGAP7P AGAP4 AGAP6

1.60e-03426757IPR011993
DomainPI3/4_kinase_CS

SMG1 ATR

1.62e-0315752IPR018936
DomainHEAT_type_2

RELCH ATR

2.08e-0317752IPR021133
DomainRasGEFN

RAPGEF6 RAPGEF2

2.88e-0320752SM00229
DomainRasGEF_N

RAPGEF6 RAPGEF2

3.18e-0321752PF00618
DomainRas-like_Gua-exchang_fac_N

RAPGEF6 RAPGEF2

3.49e-0322752IPR000651
DomainRASGEF_NTER

RAPGEF6 RAPGEF2

3.49e-0322752PS50212
DomainAnkyrin_rpt-contain_dom

AGAP5 LRRK2 AGAP7P AGAP4 AGAP6

3.56e-03254755IPR020683
DomainAnkyrin_rpt

AGAP5 LRRK2 AGAP7P AGAP4 AGAP6

4.06e-03262755IPR002110
Domain-

AGAP5 PTPN13 SBF1 DOCK9 AGAP4 AGAP6

4.84e-033917562.30.29.30
DomainTYR_PHOSPHATASE_dom

PTPN13 SBF1 TPTE2

5.18e-0387753IPR000387
DomainRASGEF_CAT

RAPGEF6 RAPGEF2

6.02e-0329752PS50009
DomainRasGEF

RAPGEF6 RAPGEF2

6.44e-0330752PF00617
Domain-

RAPGEF6 RAPGEF2

6.44e-03307521.10.840.10
DomainRas_GEF_dom

RAPGEF6 RAPGEF2

6.44e-0330752IPR023578
DomainRASGEF_cat_dom

RAPGEF6 RAPGEF2

6.44e-0330752IPR001895
DomainRasGEF

RAPGEF6 RAPGEF2

6.44e-0330752SM00147
DomainWD40_repeat_dom

MED16 LRRK2 CORO6 DDB1 PHIP

6.85e-03297755IPR017986
DomainRA

RAPGEF6 RAPGEF2

6.86e-0331752SM00314
DomainProt-tyrosine_phosphatase-like

PTPN13 SBF1 TPTE2

7.40e-0399753IPR029021
PathwayREACTOME_INSULIN_RECEPTOR_RECYCLING

INSR TCIRG1 IDE

1.41e-0430483M506
PathwayREACTOME_INSULIN_RECEPTOR_RECYCLING

INSR TCIRG1 IDE

1.56e-0431483MM15467
PathwayWP_ZINC_HOMEOSTASIS

SLC39A6 SLC39A7 SLC39A13

2.65e-0437483M39377
PathwayWP_NIPBL_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME

ATR NIPBL

3.14e-048482M42528
PathwayREACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY

SLC39A6 SLC39A7

3.14e-048482MM15106
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

LONP1 GAPVD1 SBF1 COPB1 PHF3 SYNE2 EIF5B THOC2 TRRAP DDB1 NIPBL PHIP ITPR3

1.65e-09653761322586326
Pubmed

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

AGAP5 AGAP7P AGAP4 AGAP6

2.63e-09976412640130
Pubmed

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.

AGAP5 AGAP7P AGAP4 AGAP6

4.38e-091076420664521
Pubmed

AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.

AGAP5 AGAP7P AGAP4 AGAP6

6.87e-091176415381706
Pubmed

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.

AGAP5 AGAP7P AGAP4 AGAP6

1.48e-081376427713690
Pubmed

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.

AGAP5 AGAP7P AGAP4 AGAP6

2.07e-081476422453919
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

SMG1 CCDC60 LONP1 SBF1 TPTE2 INSR EIF5B TCIRG1 SLC39A7 BBS10

2.78e-08420761028065597
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

AGAP5 PTPN13 SBF1 MAST1 AGAP7P RAPGEF2 AGAP4 AGAP6 DAGLA ARAF

3.47e-08430761032581705
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SMG1 RELCH AGAP5 GAPVD1 PDPR SBF1 AGAP7P AGAP4 AGAP6 DAGLA

2.37e-07529761014621295
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

LONP1 GAPVD1 PTPN13 RAPGEF6 FAM193A RAPGEF2 THOC2 ARAF LRCH3

5.77e-0744676924255178
Pubmed

Tel2 regulates the stability of PI3K-related protein kinases.

SMG1 ATR TRRAP

1.19e-061076318160036
Pubmed

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

SMG1 ATR TRRAP

1.63e-061176320427287
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

LONP1 GAPVD1 COPB1 SYNE2 INSR EIF5B THOC2 TRRAP DDB1 NIPBL PHIP ITPR3

2.18e-061024761224711643
Pubmed

Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes.

SLC39A6 SLC39A7

4.71e-06276211891044
Pubmed

Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility.

INSR VDR

4.71e-06276239201651
Pubmed

Different Actions of Intracellular Zinc Transporters ZIP7 and ZIP13 Are Essential for Dermal Development.

SLC39A7 SLC39A13

4.71e-06276231412620
Pubmed

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.

RAPGEF6 RAPGEF2

4.71e-06276224858808
Pubmed

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.

SLC39A6 SLC39A7

4.71e-06276225969539
Pubmed

METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.

METTL15P1 METTL15

4.71e-06276232573735
Pubmed

Ligand-dependent dynamics and intramolecular signaling in a PDZ domain.

PTPN13 RAPGEF6

4.71e-06276214698303
Pubmed

Co-Mutation of FAT3 and LRP1B in Lung Adenocarcinoma Defines a Unique Subset Correlated With the Efficacy of Immunotherapy.

FAT3 LRP1B

4.71e-06276235069585
Pubmed

Energetics of peptide recognition by the second PDZ domain of human protein tyrosine phosphatase 1E.

PTPN13 RAPGEF6

4.71e-06276217240990
Pubmed

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.

METTL15P1 METTL15

4.71e-06276235682734
Pubmed

Antitumor immunity and prognosis value elicited by FAT3 and LRP1B co-mutation in endometrial cancer.

FAT3 LRP1B

4.71e-06276238696842
Pubmed

Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions.

PTPN13 RAPGEF6

4.71e-06276212095257
Pubmed

Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.

RAPGEF6 RAPGEF2

4.71e-06276232600317
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SMG1 GAPVD1 SBF1 MED16 PHF3 TRRAP LRCH3 ITPR3

5.48e-0644076834244565
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

COPB1 PHF3 THOC2 DDB1 NIPBL PHIP LRCH3

9.84e-0634076729478914
Pubmed

Change in INSR, APBA2 and IDE Gene Expressions in Brains of Alzheimer's Disease Patients.

INSR IDE

1.41e-05376228164769
Pubmed

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.

RAPGEF6 RAPGEF2

1.41e-05376229747665
Pubmed

High-resolution arrays reveal burden of copy number variations on Parkinson disease genes associated with increased disease risk in random cohorts.

LRRK2 ATP13A2

1.41e-05376227399248
Pubmed

The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.

SMG1 ATR

1.41e-05376215279777
Pubmed

Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity.

LRRK2 ATP13A2

1.41e-05376223628791
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RELCH LONP1 PTPN13 RPGRIP1L PDPR SBF1 TPTE2 SYNE2 SLC39A6 IDE ITPR3

1.70e-051049761127880917
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

PTPN13 COPB1 MED16 EIF5B THOC2 TRRAP NIPBL PHIP

2.18e-0553376830554943
Pubmed

DCAF14 promotes stalled fork stability to maintain genome integrity.

DDB1 PHIP

2.82e-05476233503431
Pubmed

Structural imaging in the presymptomatic stage of genetically determined parkinsonism.

LRRK2 ATP13A2

2.82e-05476220483373
Pubmed

Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.

SLC39A6 SLC39A7

2.82e-05476212839489
Pubmed

LINC complex alterations in DMD and EDMD/CMT fibroblasts.

COPB1 SYNE2

2.82e-05476222555292
Pubmed

Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism.

INSR IDE

2.82e-05476227703010
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

AGAP5 SLC4A8 SLC39A6 AGAP7P AGAP4 AGAP6 DAGLA

3.02e-0540576738187761
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

AGAP5 PHF3 AGAP7P RAPGEF2 AGAP4 AGAP6

3.59e-0528176628706196
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

SBF1 ATR COPB1 DDB1

4.08e-058776417148452
Pubmed

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome.

INSR VDR

4.69e-05576221082232
Pubmed

Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.

DDB1 PHIP

4.69e-05576234171797
Pubmed

The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway.

ATR DDB1

4.69e-05576224045107
Pubmed

Influence of placental mannose/n-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors.

GIPC1 INSR

7.03e-05676222082268
Pubmed

Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.

INSR TCIRG1

7.03e-05676220655470
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

GIPC1 LONP1 ATR MED16 PHF3 EIF5B THOC2 TRRAP DDB1 NIPBL

7.10e-051014761032416067
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

OTUB2 AGAP5 ABCA4 RPGRIP1L CORO6 IDE AGAP7P TRRAP RUNDC1 AGAP4 AGAP6

7.87e-051242761130973865
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PTPN13 COL26A1 INSR RDH10 MAST1 IDE RAPGEF2 TRRAP METTL15 DAGLA VPS13B LRCH3

8.89e-051489761228611215
Pubmed

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing.

ATR DDB1

9.83e-05776220008788
Pubmed

SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.

DDB1 PHIP

9.83e-05776235320725
Pubmed

HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.

ATR DDB1

9.83e-05776219798433
Pubmed

The LZT proteins; the LIV-1 subfamily of zinc transporters.

SLC39A6 SLC39A13

1.31e-04876212659941
Pubmed

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

SMG1 ATR

1.31e-04876220810650
Pubmed

The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin.

DDB1 PHIP

1.31e-04876230018425
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SMG1 PHF3 DOCK9 SYNE2 DAGLA

1.38e-0422576512168954
Pubmed

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

AGAP5 GAPVD1 SBF1 AGAP7P AGAP4

1.38e-0422576525277244
Pubmed

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.

SMG1 ATR

1.68e-04976216488880
Pubmed

Vpr-induced DNA double-strand breaks: molecular mechanism and biological relevance.

ATR DDB1

1.68e-04976219275579
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

GAPVD1 PTPN13 RAPGEF6 FAM193A COPB1 EIF5B THOC2 DDB1 NIPBL

1.99e-0493476933916271
Pubmed

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.

RAPGEF6 RAPGEF2

2.10e-041076223885123
Pubmed

HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.

ATR DDB1

2.10e-041076218514189
Pubmed

The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.

ATR DDB1

2.10e-041076220347598
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PDPR ATR COPB1 TOR3A DDB1 ITPR3

2.34e-0439676626687479
Pubmed

Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?

LRRK2 ATP13A2

2.56e-041176219224617
Pubmed

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development.

METTL15P1 METTL15

2.56e-041176233627187
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

GAPVD1 RAPGEF6 ATR PHF3 EIF5B THOC2 TRRAP NIPBL

2.89e-0477476815302935
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

GAPVD1 PTPN13 RAPGEF6 FAM193A ARAF SLC39A7

3.13e-0441876634709266
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

PTPN13 RAPGEF6 SBF1 INSR SLC39A6 LRCH3

3.25e-0442176636976175
Pubmed

The role of oxidative stress in Parkinson's disease.

LRRK2 ATP13A2

3.62e-041376224252804
Pubmed

Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.

RAPGEF6 RAPGEF2

3.62e-041376227390776
Pubmed

Association analysis of type 2 diabetes Loci in type 1 diabetes.

RPGRIP1L IDE

3.62e-041376218426861
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

LONP1 GAPVD1 COPB1 PHF3 INSR EIF5B THOC2 DDB1 ARAF ITPR3

3.77e-041247761027684187
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

LONP1 RPGRIP1L PDPR SYNE2 IDE METTL15 DDB1 PHIP ARAF VPS13B ITPR3

3.94e-041496761132877691
Pubmed

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.

SMG1 GAPVD1 EIF5B RAPGEF2

4.18e-0415976430581152
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

PHF3 TRRAP

4.22e-041476228263302
Pubmed

A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.

SLC39A6 RAPGEF2 DSEL

4.54e-046876322779921
Pubmed

Rap2A links intestinal cell polarity to brush border formation.

RAPGEF6 RAPGEF2

4.86e-041576222797597
Pubmed

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.

SYNE2 TOR3A

4.86e-041576220457914
Pubmed

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

MED16 TRRAP

4.86e-041576218418385
Pubmed

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

SMG1 ATR

4.86e-041576220864032
Pubmed

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

PTPN13 EIF5B SLC39A6 SLC39A7 LRCH3

4.87e-0429676534186245
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

PTPN13 RAPGEF6 COPB1 FSBP

5.14e-0416876430631154
Pubmed

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.

GIPC1 PTPN13

5.54e-041676218824598
Pubmed

HIV-1 Vpr-a still "enigmatic multitasker".

ATR DDB1

5.54e-041676224744753
Pubmed

Structure-function relationship of Vpr: biological implications.

ATR DDB1

5.54e-041676219275588
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GAPVD1 PTPN13 RAPGEF6 SBF1 PHF3 SYNE2 RAPGEF2 ARAF

5.84e-0486176836931259
Pubmed

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

MED16 VDR

6.27e-041776210235266
Pubmed

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.

MED16 VDR

7.05e-041876210198638
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

SMG1 ATR IDE DAGLA

7.53e-0418676433637726
Pubmed

Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes.

METTL15P1 METTL15

7.87e-041976219474196
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

SMG1 GAPVD1 ATR MED16 INSR EIF5B TRRAP ARAF

8.36e-0491076836736316
Pubmed

The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.

DDB1 PHIP

8.73e-042076231911655
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

PHF3 NIPBL PHIP

9.01e-048676337253089
Pubmed

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.

DDB1 VDR

9.63e-042176212840015
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

SBF1 ATR EIF5B ITPR3

1.02e-0320276433005030
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

LONP1 GAPVD1 ATR COPB1 EIF5B IDE THOC2 DDB1 NIPBL PHIP

1.05e-031425761030948266
Pubmed

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.

OTUB2 RAPGEF6 RAPGEF2

1.06e-039176330472188
InteractionSIRT7 interactions

LONP1 GAPVD1 SBF1 ATR COPB1 PHF3 SYNE2 EIF5B THOC2 TRRAP DDB1 NIPBL PHIP ITPR3

5.37e-077447514int:SIRT7
GeneFamilyArfGAPs

AGAP5 AGAP7P AGAP4 AGAP6

2.94e-0633554395
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP5 AGAP4 AGAP6

1.76e-05175531291
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AGAP5 SBF1 DOCK9 AGAP7P AGAP4 AGAP6

3.70e-05206556682
GeneFamilyPDZ domain containing

GIPC1 PTPN13 RAPGEF6 MAST1 RAPGEF2

9.75e-051525551220
GeneFamilyParkinson disease associated genes

LRRK2 ATP13A2

1.06e-0316552672
GeneFamilyMethyltransferase like

METTL15 METTL22

4.52e-0333552963
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

GAPVD1 PTPN13 FAM193A ATR PHF3 DOCK9 SYNE2 RAPGEF2 THOC2 TRRAP NIPBL PHIP VPS13B

8.56e-078567513M4500
CoexpressionTHEODOROU_MAMMARY_TUMORIGENESIS

AGAP5 AGAP7P AGAP4 AGAP6

3.80e-0637754MM1121
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN

AGAP5 AGAP7P AGAP4 AGAP6

7.69e-0644754MM485
CoexpressionGSE7218_IGM_VS_IGG_SIGNAL_THGOUGH_ANTIGEN_BCELL_UP

SLC4A8 MED16 RTTN ABHD8 ATP13A2 DDB1

1.63e-05187756M6807
CoexpressionGSE22432_CDC_VS_COMMON_DC_PROGENITOR_UP

SMG1 RELCH OTUB2 INSR CORO6 RAPGEF2

2.38e-05200756M7831
CoexpressionKARLSSON_TGFB1_TARGETS_DN

AGAP5 PTPN13 SYNE2 AGAP7P AGAP4 AGAP6

3.05e-05209756MM1058
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

SMG1 RELCH FAM193A PHF3 FAT3 INSR IDE PHIP VPS13B

8.43e-06385759gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000

RELCH FAM193A PHF3 FAT3 INSR IDE PHIP VPS13B

4.72e-05369758DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 RELCH PHF3 SYNE2 RTTN VPS13B

1.17e-06199766f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

PHF3 SYNE2 INSR EIF5B THOC2 NIPBL

1.17e-06199766fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tfh|Liver / Manually curated celltypes from each tissue

PTPN13 DOCK9 METTL15 AGAP4 BBS10

7.12e-0615676585bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL26A1 FAT3 SYNE2 EFCAB13 LRRK2

1.89e-05191765d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 RELCH SYNE2 VPS13B LRCH3

1.99e-051937659337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

PHF3 SYNE2 INSR EIF5B NIPBL

2.30e-05199765c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 COL26A1 SYNE2 LRRK2 ITPR3

2.30e-051997652e7f517c0444b4f29ff11c26ab32e9cc0f7e99ef
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 PHF3 SYNE2 NIPBL PHIP

2.36e-0520076512f1685ce8f218433068e090c9d839cd5a1910bf
Diseasecerebral palsy (implicated_via_orthology)

AGAP5 AGAP7P AGAP4 AGAP6

7.16e-0910734DOID:1969 (implicated_via_orthology)
DiseaseOvarian Serous Adenocarcinoma

LRRK2 MAST1 TRRAP

2.48e-0523733C1335177
Diseaselung cancer (is_implicated_in)

ATR MPZL3 LRP1B DAGLA

3.48e-0574734DOID:1324 (is_implicated_in)
Diseasecolon cancer (is_implicated_in)

PTPN13 ATR LRP1B

9.78e-0536733DOID:219 (is_implicated_in)
DiseaseParkinson's disease (implicated_via_orthology)

GIPC1 INSR TOR3A ATP13A2

6.31e-04157734DOID:14330 (implicated_via_orthology)
DiseaseParkinson's disease (is_implicated_in)

LRRK2 ATP13A2 VDR

8.97e-0476733DOID:14330 (is_implicated_in)
Diseasebody weight

RELCH GAPVD1 RPGRIP1L COPB1 PHF3 RTTN INSR METTL15 LRP1B NIPBL

1.05e-0312617310EFO_0004338
DiseaseInfiltrating duct carcinoma of female breast

SMG1 ATR

1.23e-0321732C3165106
DiseaseParkinson Disease

INSR LRRK2 ATP13A2

1.24e-0385733C0030567
DiseaseParkinson disease

LRRK2 ATP13A2

1.35e-0322732cv:C0030567
Diseasediffusing capacity of the lung for carbon monoxide

COL26A1 INSR LRP1B

1.76e-0396733EFO_0009369
DiseaseDisorder of eye

ABCA4 RPGRIP1L ATP13A2 BBS10

1.91e-03212734C0015397
Diseasealcohol use disorder measurement

SLC4A8 METTL15 PHIP SLC39A13

1.98e-03214734EFO_0009458
DiseaseAutosomal Dominant Parkinsonism

LRRK2 ATP13A2

2.19e-0328732C0752098
DiseaseAutosomal Dominant Juvenile Parkinson Disease

LRRK2 ATP13A2

2.19e-0328732C0752097
DiseaseParkinsonism, Experimental

LRRK2 ATP13A2

2.19e-0328732C0752101
DiseaseAutosomal Recessive Parkinsonism

LRRK2 ATP13A2

2.19e-0328732C0752100
DiseaseFamilial Juvenile Parkinsonism

LRRK2 ATP13A2

2.19e-0328732C0752104
DiseaseRamsay Hunt Paralysis Syndrome

LRRK2 ATP13A2

2.19e-0328732C0242423
DiseasePARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE

LRRK2 ATP13A2

2.19e-0328732C1868675
Diseasebrain measurement, neuroimaging measurement

COL26A1 COPB1 FAT3 EFCAB13 CORO6 ATP13A2

2.42e-03550736EFO_0004346, EFO_0004464

Protein segments in the cluster

PeptideGeneStartEntry
HEEEHVLLMAICIVS

VDR

326

P11473
PAEVTVEVGEDLHMH

AGAP4

51

Q96P64
VIDFEMQPIHEVLRH

C8A

456

P07357
NELMDVVLHHVPEAK

ABCA4

1206

P78363
VIAPLAEHHVSVLML

CASTOR1

101

Q8WTX7
IDHIHLISVGDMIEA

GIPC1

166

O14908
EALHLEHPIARMIVD

BBS10

56

Q8TAM1
IMDPPVTDDIHIHQL

FAM193A

226

P78312
AELTVPVLLVHGMHD

ABHD8

356

Q96I13
PAEVTVEVGEDLHMH

AGAP6

51

Q5VW22
IEFVREHIIHMPQED

CCDC60

516

Q8IWA6
ETVDHQPVHLRVMDT

RASL12

61

Q9NYN1
MLHVHVDRDPQELVT

ITPR3

781

Q14573
HEVEPMATECDHIQI

OTUB2

166

Q96DC9
EHLSPEHEVILSSMI

RELCH

1146

Q9P260
PEEIGHLRHLMELDV

LRCH3

166

Q96II8
VITMSEDDHPHVLAL

LRP1B

2311

Q9NZR2
TEEMLPIHQDELLAH

MAGEE2

326

Q8TD90
EVEHIPEIEINMLTV

RPGRIP1L

1001

Q68CZ1
HEPIMQLLVEDEDHL

GAPVD1

201

Q14C86
VHDLVGAMHVPEDAV

PDPR

171

Q8NCN5
HPAHERVLQDLVMDI

COPB1

311

P53618
QTQEEPLFIMHHIDI

NIPBL

2441

Q6KC79
LELMQKHIHSPEVAE

LRRK2

446

Q5S007
VHHNIPMTELTVTER

MPZL3

136

Q6UWV2
LPAEVLMVEVENVVH

LONP1

266

P36776
LHIPVMVDEVVHCLS

METTL15P1

71

P0C7V9
PVTHEIFENNVVHLM

INSR

856

P06213
LHIPVMVDEVVHCLS

METTL15

71

A6NJ78
EPVHGMVHPEVVELI

MAST1

1026

Q9Y2H9
QDLTRMIHILDTEHP

MED16

56

Q9Y2X0
VPDIVQMHIETLEAV

SBF1

856

O95248
IIITIQHETVLHEPM

OR56B4

51

Q8NH76
LIVEVLEDVPLTMHN

ARAF

86

P10398
MVAPQEHLIIVHATH

ATP13A2

766

Q9NQ11
HSHDEVFVVLMEIIA

ATR

2151

Q13535
NVSIPHHEEVIMAEL

BMP10

131

O95393
HHTDLNPIEVAIDEM

DOCK9

1941

Q9BZ29
IDVVVHVEQLVHEML

FAT3

3631

Q8TDW7
PAEVTVEVGEDLHMH

AGAP7P

51

Q5VUJ5
VLLSLDDMHPDVIHS

CORO6

166

Q6QEF8
NAILTVMLRHVPEHE

EFCAB13

866

Q8IY85
LAMVPGHHIVSIEVQ

NAA38

101

Q9BRA0
AFNEVIISPAMLHEH

DAGLA

636

Q9Y4D2
EEGLLHVEDIILHMF

IDE

381

P14735
TMAILLHEIPHEVGD

SLC39A13

251

Q96H72
EGHHMDLPDVVITSL

DSEL

846

Q8IZU8
ERVLILEHMIGIHDP

COL26A1

376

Q96A83
HTEMEHEVACLDITP

DDB1

531

Q16531
IHAPQEEEVTSLHEM

NIPAL1

186

Q6NVV3
DVFDMVVAHIGLVEH

PTPN13

596

Q12923
LLTAIHMVLTEHDPF

RUNDC1

516

Q96C34
SISLEQPEVMLVHHR

RTTN

456

Q86VV8
PERLIMHLIEEHSIV

RAPGEF6

421

Q8TEU7
MHLIEEHSIVDPTYI

RAPGEF6

426

Q8TEU7
PHFSVTSIDHDIMLI

PRSS58

91

Q8IYP2
VEDVMVLKEQIEHLH

SYNE2

5881

Q8WXH0
DIAILVVDIMHGLEP

EIF5B

721

O60841
LMIVHSDLAVHFPAI

SMG1

646

Q96Q15
HVPHELFTELDEICM

SLC4A8

111

Q2Y0W8
IVHEMELPHVSALEV

TBC1D26

51

Q86UD7
HDIIRIEHTMATPLE

METTL22

166

Q9BUU2
LPTMLEINHGHIVTV

RDH10

181

Q8IZV5
VLEEEEVMIAHAHPQ

SLC39A6

511

Q13433
PAEVTVEVGEDLHMH

AGAP5

51

A6NIR3
MHLVEEHSVVDPTFI

RAPGEF2

281

Q9Y4G8
VMAPVHEAVVSLHVS

THOC2

856

Q8NI27
VLMGHEDEVFVLEPH

PHIP

461

Q8WWQ0
TTMTVLLHEVPHEVG

SLC39A7

351

Q92504
VMLDHHPVAITVEVK

FSBP

141

O95073
MDIVDTFNHLIPTEH

PHF3

1

Q92576
EHSVPMYAEQLVHVV

VPS13B

701

Q7Z7G8
IVHEMELPRVSALEV

TBC1D28

51

Q2M2D7
VSRIMIDDHNVPTLH

TPTE2

281

Q6XPS3
IDDHNVPTLHEMVVF

TPTE2

286

Q6XPS3
EITMEHLEPHLQAEI

TOR3A

296

Q9H497
ATIEVDQIHTHMRPL

TRRAP

1416

Q9Y4A5
ELVPSEVLMHQAIHT

TCIRG1

706

Q13488