Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	maintenance of protein complex location	TMEM232 EPG5	1.88e-05	2	90	2	GO:0098544
Domain	Rho_GTPase_activation_prot	PLXNA3 ARHGAP31 GMIP SYDE1	7.94e-04	88	88	4	IPR008936
Domain	Sugar_P_trans_dom	SLC35C2 SLC35E4	9.64e-04	10	88	2	IPR004853
Domain	TPT	SLC35C2 SLC35E4	9.64e-04	10	88	2	PF03151
Domain	-	NOD1 DTHD1 DEDD NLRP13	9.76e-04	93	88	4	1.10.533.10
Domain	ARM-type_fold	AP4E1 RNPEP PIK3CD ARID2 SCYL3 UTP20 TBCD	1.10e-03	339	88	7	IPR016024
Domain	DEATH-like_dom	NOD1 DTHD1 DEDD NLRP13	1.23e-03	99	88	4	IPR011029
Domain	FERM_M	MYLIP FRMPD3 MYO15A	1.33e-03	46	88	3	PF00373
Domain	HEAT	SCYL3 UTP20 TBCD	1.50e-03	48	88	3	PF02985
Domain	FERM_central	MYLIP FRMPD3 MYO15A	1.59e-03	49	88	3	IPR019748
Domain	FERM_domain	MYLIP FRMPD3 MYO15A	1.59e-03	49	88	3	IPR000299
Domain	FERM_1	MYLIP FRMPD3 MYO15A	1.69e-03	50	88	3	PS00660
Domain	FERM_2	MYLIP FRMPD3 MYO15A	1.69e-03	50	88	3	PS00661
Domain	FERM_3	MYLIP FRMPD3 MYO15A	1.69e-03	50	88	3	PS50057
Domain	Band_41_domain	MYLIP FRMPD3 MYO15A	1.69e-03	50	88	3	IPR019749
Domain	B41	MYLIP FRMPD3 MYO15A	1.69e-03	50	88	3	SM00295
Domain	Laminin_N	LAMB4 LAMA5	2.52e-03	16	88	2	IPR008211
Domain	LAMININ_NTER	LAMB4 LAMA5	2.52e-03	16	88	2	PS51117
Domain	Laminin_N	LAMB4 LAMA5	2.52e-03	16	88	2	PF00055
Domain	LamNT	LAMB4 LAMA5	2.52e-03	16	88	2	SM00136
Domain	HEAT	SCYL3 UTP20 TBCD	2.59e-03	58	88	3	IPR000357
Domain	PCI_dom	EIF3E PCID2	2.85e-03	17	88	2	IPR000717
Domain	PCI	EIF3E PCID2	2.85e-03	17	88	2	PF01399
Domain	RhoGAP	ARHGAP31 GMIP SYDE1	3.13e-03	62	88	3	SM00324
Domain	RhoGAP	ARHGAP31 GMIP SYDE1	3.27e-03	63	88	3	PF00620
Domain	RHOGAP	ARHGAP31 GMIP SYDE1	3.42e-03	64	88	3	PS50238
Domain	RhoGAP_dom	ARHGAP31 GMIP SYDE1	3.42e-03	64	88	3	IPR000198
Domain	-	ARHGAP31 GMIP SYDE1	3.42e-03	64	88	3	1.10.555.10
Domain	HEAT_REPEAT	SCYL3 UTP20 TBCD	4.41e-03	70	88	3	PS50077
Domain	NACHT	NOD1 NLRP13	5.21e-03	23	88	2	PS50837
Domain	NACHT_NTPase	NOD1 NLRP13	5.21e-03	23	88	2	IPR007111
Domain	EGF_LAM_2	LAMB4 LAMA5	8.76e-03	30	88	2	PS50027
Domain	EGF_LAM_1	LAMB4 LAMA5	8.76e-03	30	88	2	PS01248
Domain	ARM-like	AP4E1 ARID2 SCYL3 UTP20 TBCD	9.00e-03	270	88	5	IPR011989
Domain	Leu-rich_rpt	NOD1 LGR6 LRRC41 NLRP13 GP5	9.13e-03	271	88	5	IPR001611
Domain	Sema	PLXNA3 SEMA4B	9.34e-03	31	88	2	SM00630
Domain	Semap_dom	PLXNA3 SEMA4B	9.34e-03	31	88	2	IPR001627
Domain	Sema	PLXNA3 SEMA4B	9.34e-03	31	88	2	PF01403
Domain	SEMA	PLXNA3 SEMA4B	9.34e-03	31	88	2	PS51004
Pubmed	Genomic analysis of mouse retinal development.	CCND3 TRNP1 ABCA2 ZNF219 ARHGAP31 GLG1 PLK5 SCYL3 BTBD17 UTP20 ALG3 PCID2 LRRC41	4.04e-06	1006	96	13	15226823
Pubmed	Maternal DRD2, SLC6A3, and OXTR genotypes as potential moderators of the relation between maternal history of care and maternal cortisol secretion in the context of mother-infant separation.	SLC6A3 OXTR	7.54e-06	2	96	2	28890000
Pubmed	Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder.	SLC6A3 OXTR	2.26e-05	3	96	2	30522820
Pubmed	Distinct neural mechanisms for the prosocial and rewarding properties of MDMA.	SLC6A3 OXTR	2.26e-05	3	96	2	31826983
Pubmed	BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.	TREX2 PCID2	2.26e-05	3	96	2	24896180
Pubmed	A novel MEK2/PI3Kδ pathway controls the expression of IL-1 receptor antagonist in IFN-β-activated human monocytes.	PIK3CD IL1RN	2.26e-05	3	96	2	20837746
Pubmed	Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.	LAMA5 LGR6	4.51e-05	4	96	2	33972551
Pubmed	Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.	UGT1A5 NR1I3	4.51e-05	4	96	2	12644700
Pubmed	Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk.	LAMA5 LGR6	4.51e-05	4	96	2	34128985
Pubmed	Biased Oxytocinergic Modulation of Midbrain Dopamine Systems.	SLC6A3 OXTR	1.12e-04	6	96	2	28669546
Pubmed	The human TREX-2 complex is stably associated with the nuclear pore basket.	TREX2 PCID2	1.12e-04	6	96	2	23591820
Pubmed	Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.	ANKLE1 PTHLH	1.12e-04	6	96	2	24325915
Pubmed	Gating of social reward by oxytocin in the ventral tegmental area.	SLC6A3 OXTR	1.12e-04	6	96	2	28963257
Pubmed	A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.	DDR2 DEDD	1.57e-04	7	96	2	15238534
Pubmed	Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.	ALG3 CNOT1	1.57e-04	7	96	2	29547901
Pubmed	An airway-to-brain sensory pathway mediates influenza-induced sickness.	PIEZO2 OXTR	2.09e-04	8	96	2	36890237
Pubmed	Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.	EIF3E PTHLH	2.09e-04	8	96	2	17516841
Pubmed	Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.	HPS1 MYO15A	2.09e-04	8	96	2	15702992
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CCND3 FANCD2 SEMA4B VPS18 NOD1 FBXL18 ARID2 RECQL5 MYLIP ALG3 CNOT1 LRRC41	2.94e-04	1327	96	12	32694731
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	SPAST MYLIP SHOC1 TUBGCP4 CNOT1 TBCD	3.21e-04	331	96	6	19490893
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	PLXNA3 GLG1 LAMA5 PTHLH TBCD	3.27e-04	214	96	5	22199357
Pubmed	Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.	SPAST IL1RN	3.34e-04	10	96	2	24182552
Pubmed	The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.	FANCD2 CENPA	4.08e-04	11	96	2	24800743
Pubmed	Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation.	CCND3 PTHLH	4.08e-04	11	96	2	11748145
Pubmed	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	AP4E1 FHIP1A	5.77e-04	13	96	2	32073997
Pubmed	SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.	SHOC1 POLR1B	5.77e-04	13	96	2	30746471
Pubmed	Mouse models of psoriasis.	TTC7A IL1RN	5.77e-04	13	96	2	17429444
Pubmed	A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.	EIF3E PTHLH	6.71e-04	14	96	2	25064007
Pubmed	Niche-mediated repair of airways is directed in an occupant-dependent manner.	PIEZO2 LGR6	6.71e-04	14	96	2	36543133
Pubmed	Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice.	CCND3 DEDD	7.73e-04	15	96	2	21135503
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	RNPEP GLG1 TUBGCP4 CNOT1 PCID2 TBCD LRRC41	9.37e-04	560	96	7	35241646
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCND3 PLXNA3 TRNP1 SEMA4B PDE2A ABCA2 PIK3CD LAMA5 ANKLE1 TBCD	9.60e-04	1105	96	10	35748872
Pubmed	Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.	LAMB4 LAMA5	1.12e-03	18	96	2	11311202
Pubmed	E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.	GLG1 PTHLH	1.12e-03	18	96	2	20530870
Pubmed	Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.	IL1RN FCRL6	1.25e-03	19	96	2	22939635
Pubmed	Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.	SHOC1 POLR1B	1.53e-03	21	96	2	30272023
Pubmed	Genome-wide association studies identify four ER negative-specific breast cancer risk loci.	LGR6 PTHLH	1.53e-03	21	96	2	23535733
Pubmed	TIM-1 Ubiquitination Mediates Dengue Virus Entry.	SLC12A3 DDR2	1.84e-03	23	96	2	29742433
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	PLXNA3 SEMA4B	2.00e-03	24	96	2	15869472
Pubmed	Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia.	PIEZO2 GPR179	2.17e-03	25	96	2	35681537
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	AP4E1 TTC39B CATIP GLG1 ARID2 PLD3 MYO15A FHIP1A PTHLH RHOT1	2.28e-03	1242	96	10	30973865
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE2A PIK3CD	2.53e-03	27	96	2	11156964
Pubmed	The AP-3 complex: a coat of many colours.	AP4E1 HPS1	2.72e-03	28	96	2	9714600
Cytoband	1q23.3	DDR2 DEDD NR1I3	1.52e-04	49	96	3	1q23.3
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYLIP FRMPD3 MYO15A	7.36e-04	50	64	3	1293
GeneFamily	Laminin subunits	LAMB4 LAMA5	7.96e-04	12	64	2	626
Disease	Delirium	SLC6A3 IL1RN	4.44e-04	10	94	2	C0011206
Disease	triple-negative breast cancer	ANKLE1 PTHLH	4.44e-04	10	94	2	EFO_0005537
Disease	osteoarthritis, hip, osteoarthritis, knee	GLT8D1 THSD7B PTHLH	1.03e-03	62	94	3	EFO_0004616, EFO_1000786
Disease	MHPG measurement, 5-HIAA measurement	CCND3 PIEZO2	1.32e-03	17	94	2	EFO_0005132, EFO_0005133
Disease	estrogen-receptor negative breast cancer	ANKLE1 LGR6 PTHLH	1.53e-03	71	94	3	EFO_1000650
Disease	prostate cancer, disease progression measurement	RECQL5 PCID2	2.65e-03	24	94	2	EFO_0008336, MONDO_0008315
Disease	systemic mastocytosis	TTC39B ABCA2	2.87e-03	25	94	2	MONDO_0016586
Disease	blood chromium measurement	LGR6 SMIM21	3.10e-03	26	94	2	EFO_0007579

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLSHLLLFLHLDSGV	EPG5	1081	Q9HCE0
LGVHLLHRALLVFLA	ANKLE1	586	Q8NAG6
IAHDFLAFILHRLSL	CCND3	156	P30281
FRAFELLHLHLDLRA	RNPEP	31	Q9H4A4
EALFLHRAFHLALLT	ALG3	281	Q92685
HAHRLLLGLHSELFL	BTBD17	81	A6NE02
HLELSLCLFLAHLLF	ADGRE4P	226	Q86SQ3
LLLSAHSHFISLRQL	ARID2	316	Q68CP9
SFSLRLYEHIHDLSL	ECT2L	801	Q008S8
HLTHRDVRVLSFLFV	DEDD	36	O75618
SLFLHESHELLLLLV	AP4E1	121	Q9UPM8
RHLLETFFRHLFSQV	DUOX1	761	Q9NRD9
EFLELLFHFHGTLRK	NR1I3	241	Q14994
AFLLSLAALRDNHTH	PLD3	376	Q8IV08
RLLLHFFCDITALLH	OR10AC1	176	Q8NH08
LFHRVLFEVHSLKLL	NRBP2	301	Q9NSY0
LHNELLLSAAFHTAR	GPR179	581	Q6PRD1
FHHLRFLEELRLSGN	LGR6	86	Q9HBX8
HHAEAVSIFKLILRF	MYO15A	2081	Q9UKN7
FLQIDLHTLHFITLV	DDR2	86	Q16832
LRHLVAHLFRVAARF	GMIP	686	Q9P107
LHPLRSALRLLFSFH	FCRL6	136	Q6DN72
ATHLVYLRLLFFIHD	GPR27	196	Q9NS67
LLHSRAFVLTFIHTL	PLXNA3	1336	P51805
EFFRLLHDLHLLAFA	FAM157A	151	C9JC47
FLFLHTLFIQRGRHE	RHOT1	251	Q8IXI2
LALIFLIRGDTHLHT	OR5A1	46	Q8NGJ0
LATDLAHHLRIFKDL	PDE2A	766	O00408
FFRLLHDLHLLAFPT	FAM157C	156	P0CG43
LRFLASEHALLLLFS	PLK5	256	Q496M5
SFVLHHFPKRLALDL	NOD1	696	Q9Y239
FFLHIKEALLAGHLL	MYLIP	96	Q8WY64
SIRLAHDHFLSNLLA	TUBGCP4	556	Q9UGJ1
LVLAVALFLLVLHHN	GLT8D1	11	Q68CQ7
ALFLLVLHHNFLSLS	GLT8D1	16	Q68CQ7
DLFSFILDFLRTHQL	KCNRG	56	Q8N5I3
GIHEAHLLFFILFLT	OR6Q1	21	Q8NGQ2
HAARDTLASVFRLLH	LAMA5	2431	O15230
SNVLFLLDFHSHLTR	MPND	276	Q8N594
LFTGHLFHELVQRFL	OXTR	331	P30559
VFFFAVILHLSHLLH	PRNT	6	Q86SH4
DILLALIFLHDRGHL	SCYL3	106	Q8IZE3
LLLLHEALAKHEAFF	PCID2	291	Q5JVF3
FRLSAALHLLLLFAA	GLG1	11	Q92896
SEFFRLLHDLHLLAF	FAM157B	151	P0CG42
LLHDLHLLAFATKRI	FAM157B	156	P0CG42
LLEIFLRFILLHQHE	FHIP1A	351	Q05DH4
FLVHLFEDAYLLTLH	CENPA	101	P49450
DRLSLRFIEHFALVL	FRMPD3	211	Q5JV73
TLHLVGHLLAFLDLL	GLB1L	376	Q6UWU2
LFQHLERSLDALHLS	ABCA2	1291	Q9BZC7
IDDRSLAFHIIFSLL	ADGRF2	671	Q8IZF7
HPEAHALISDFLLFL	CATIP	321	Q7Z7H3
LTTRIAHFLDRHLVF	EIF3E	6	P60228
LYEHLERFIVLHLSS	DTHD1	471	Q6ZMT9
LFLHSHNLTLLTLFE	GP5	261	P40197
FHFVAFILLTRHRTA	KCNMB3	11	Q9NPA1
IRLDLEALFRFSHLI	LAMB4	116	A4D0S4
GLRSHLITLLLFLFH	IL1RN	6	P18510
ALHAFLLVHSKLLAF	HPS1	206	Q92902
FFPLFLEHLLSDHIS	MFSD13A	286	Q14CX5
LLLHNSHAFFRELDI	FANCD2	916	Q9BXW9
LFIIILSYLDSHLHT	OR2J3	46	O76001
LLLDHLRLVSSFHAY	SYDE1	531	Q6ZW31
HIFIESGLRLLHLSL	UTP20	2081	O75691
LASSLHTLKFRHLLF	LRRC41	191	Q15345
HTLKFRHLLFSDVAA	LRRC41	196	Q15345
VHLLGFSDEILLHIL	FBXL18	26	Q96ME1
LLLDTHRGLLYAASH	SEMA4B	501	Q9NPR2
FKHAALLHLLVTIRD	SHOC1	656	Q5VXU9
ALLLDTAAHFSHRLG	SWSAP1	116	Q6NVH7
FALLRLVAFHLGLLF	SPAST	61	Q9UBP0
LRLFHSFEELLLEAH	RWDD2A	236	Q9UIY3
LIFRTFDLFLVIHHL	CLN8	126	Q9UBY8
IAIEVLHLLLSHLLF	CNOT1	176	A5YKK6
ELFKGFARHLSHLLT	RECQL5	936	O94762
LESRLHFRIQAALHL	TTC39B	661	Q5VTQ0
SLEFKLHRLHFIRLL	RMND5B	191	Q96G75
LVFLRLFIFFLHGHL	TMEM232	171	C9JQI7
LLLHALLLFVADAAF	VSTM2B	16	A6NLU5
LFASRASIHELLASH	VPS18	536	Q9P253
DEFQLLHRHRELFTL	SLC6A3	436	Q01959
LHRHRELFTLFIVLA	SLC6A3	441	Q01959
RFSLDFNLRTHLRIH	YY2	321	O15391
ISLSFLLLHIIFHIT	PIEZO2	66	Q9H5I5
ALIRHLHATSFDVVL	UGT1A5	136	P35504
ILRRHGLLFLHLFAL	PIK3CD	966	O00329
LHLAVIFLFSALSRA	SLC35C2	51	Q9NQQ7
SLLSKFRLGFHEVHI	SLC12A3	881	P55017
LEYLIRHLAHIASFS	ARHGAP31	146	Q2M1Z3
RRFFLHHLIAEIHTA	PTHLH	56	P12272
NEHHIRFFTLLVLFH	SMIM21	46	Q3B7S5
AHALHLLALLFSAQK	TTC7A	566	Q9ULT0
FTLALSALLLGRRHH	SLC35E4	146	Q6ICL7
RFRAHAASVFLTLLH	TBCD	916	Q9BTW9
FLLLSLLLSHAAHLE	THSD7B	21	Q9C0I4
EGDVHTLLLIFLHRA	TREX2	191	Q9BQ50
ERDALLAHGTSFLLH	POLR1B	1041	Q9H9Y6
LAHGTSFLLHDRLFN	POLR1B	1046	Q9H9Y6
HRVFLAAELRLAHRA	TRNP1	131	Q6NT89
FRFNSILALHLRAHP	ZNF219	66	Q9P2Y4
AESASLQFHILRLFH	NLRP13	626	Q86W25