Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF729 ZNF823 ZNF355P ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

6.06e-0714124815GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF729 ZNF823 ZNF355P ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

9.18e-0714594815GO:0000977
GeneOntologyMolecularFunctioncytokine binding

TRAF2 ADAM17 LTBP3 CHRDL2 ITGB1 ITGB3

2.01e-06157486GO:0019955
GeneOntologyMolecularFunctioninsulin receptor activity

IGF1R INSRR

1.69e-053482GO:0005009
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

IGF1R EGFR EPHA4 INSRR

1.79e-0565484GO:0004714
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

IGF1R EGFR EPHA4 INSRR

5.16e-0585484GO:0019199
GeneOntologyMolecularFunctionC-X3-C chemokine binding

ITGB1 ITGB3

5.63e-055482GO:0019960
GeneOntologyMolecularFunctionintegrin binding

CCN6 ADAM17 EGFR ITGB1 ITGB3

6.16e-05175485GO:0005178
GeneOntologyMolecularFunctiontumor necrosis factor binding

TRAF2 ADAM17

1.18e-047482GO:0043120
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF729 ZNF355P ZNF490 ZNF778 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728

1.40e-0412444811GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF729 ZNF355P ZNF490 ZNF778 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728

1.69e-0412714811GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF729 ZNF778 ZNF229 ZNF493 ZNF43 ZNF268 ZNF726

3.57e-04560487GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF729 ZNF778 ZNF229 ZNF493 ZNF43 ZNF268 ZNF726

3.80e-04566487GO:0001216
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

IGF1R EGFR EPHA4 INSRR

4.05e-04145484GO:0004713
GeneOntologyMolecularFunctioninsulin-like growth factor I binding

IGF1R ITGB3

4.34e-0413482GO:0031994
GeneOntologyMolecularFunctiongrowth factor binding

LTBP3 IGF1R EGFR ITGB3

5.34e-04156484GO:0019838
GeneOntologyMolecularFunctioncell adhesion molecule binding

CCN6 ADAM17 TES EGFR ITGB1 ITGB3 PAICS

5.34e-04599487GO:0050839
GeneOntologyMolecularFunctioninsulin receptor substrate binding

IGF1R INSRR

5.82e-0415482GO:0043560
GeneOntologyMolecularFunctioninsulin-like growth factor binding

IGF1R ITGB3

9.43e-0419482GO:0005520
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF729 ZNF493 FEZF1 ZNF43 ZNF726

9.97e-04320485GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF729 ZNF493 FEZF1 ZNF43 ZNF726

1.08e-03326485GO:0001217
GeneOntologyMolecularFunctionvirus receptor activity

EGFR ITGB1 ITGB3

1.12e-0385483GO:0001618
GeneOntologyMolecularFunctionexogenous protein binding

EGFR ITGB1 ITGB3

1.16e-0386483GO:0140272
GeneOntologyMolecularFunctionprotein-hormone receptor activity

IGF1R INSRR

1.27e-0322482GO:0016500
GeneOntologyMolecularFunctionchemokine binding

ITGB1 ITGB3

2.85e-0333482GO:0019956
GeneOntologyMolecularFunctionsphingolipid binding

LAMC1 TRAF2

3.02e-0334482GO:0046625
GeneOntologyMolecularFunctionubiquitin conjugating enzyme binding

RNF144A ARIH2

3.38e-0336482GO:0031624
GeneOntologyMolecularFunctionprotein kinase regulator activity

SPRY2 MT3 EGFR SPRY4

3.44e-03259484GO:0019887
GeneOntologyMolecularFunctionfibronectin binding

ITGB1 ITGB3

3.76e-0338482GO:0001968
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme binding

RNF144A ARIH2

4.58e-0342482GO:0044390
GeneOntologyMolecularFunctionprotein kinase binding

NELL1 SPRY2 TRAF2 EGFR ITGB1 ITGB3 EPHA4

4.59e-03873487GO:0019901
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

IGF1R INSRR

4.80e-0343482GO:0043548
GeneOntologyMolecularFunctionprotein kinase activator activity

SPRY2 MT3 EGFR

5.51e-03149483GO:0030295
GeneOntologyMolecularFunctionkinase regulator activity

SPRY2 MT3 EGFR SPRY4

6.12e-03305484GO:0019207
GeneOntologyMolecularFunctionkinase activator activity

SPRY2 MT3 EGFR

6.59e-03159483GO:0019209
GeneOntologyMolecularFunctionkinase binding

NELL1 SPRY2 TRAF2 EGFR ITGB1 ITGB3 EPHA4

8.02e-03969487GO:0019900
GeneOntologyMolecularFunctioncadherin binding

TES EGFR ITGB1 PAICS

8.83e-03339484GO:0045296
GeneOntologyMolecularFunctionprotein kinase C binding

NELL1 ITGB3

1.10e-0266482GO:0005080
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

VWC2L SPRY2 ADAM17 MT3 BMPER CHRDL2 FST ITGB1 ITGB3 SPRY4

2.43e-084124710GO:0090287
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

VWC2L SPRY2 ADAM17 LTBP3 IGF1R MT3 BMPER CHRDL2 EGFR FST ITGB1 ITGB3 SPRY4 EPHA4 INSRR

2.99e-0811864715GO:0007167
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

VWC2L SPRY2 ADAM17 LTBP3 IGF1R MT3 BMPER CHRDL2 EGFR FST ITGB1 ITGB3 SPRY4

3.46e-088504713GO:0071363
GeneOntologyBiologicalProcessresponse to growth factor

VWC2L SPRY2 ADAM17 LTBP3 IGF1R MT3 BMPER CHRDL2 EGFR FST ITGB1 ITGB3 SPRY4

5.41e-088834713GO:0070848
GeneOntologyBiologicalProcessregulation of kinase activity

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB3 SPRY4 EPHA4 INSRR

2.64e-066864710GO:0043549
GeneOntologyBiologicalProcesspositive regulation of kinase activity

TRAF2 ADAM17 IGF1R MT3 EGFR ITGB3 EPHA4 INSRR

3.32e-06405478GO:0033674
GeneOntologyBiologicalProcesstransposable element silencing

ZNF729 ZNF493 ZNF43 ZNF726

3.60e-0646474GO:0010526
GeneOntologyBiologicalProcessretrotransposition

ZNF729 ZNF493 ZNF43 ZNF726

4.28e-0648474GO:0032197
GeneOntologyBiologicalProcesspositive regulation of MAPK cascade

SPRY2 TRAF2 ADAM17 IGF1R MT3 BMPER EGFR ITGB3 EPHA4

4.78e-06571479GO:0043410
GeneOntologyBiologicalProcesstransposition

ZNF729 ZNF493 ZNF43 ZNF726

5.05e-0650474GO:0032196
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine kinase signaling pathway

SPRY2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 SPRY4 EPHA4 INSRR

5.62e-067474710GO:0007169
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

VWC2L SPRY2 ADAM17 LTBP3 BMPER CHRDL2 FST ITGB1

6.63e-06445478GO:0141091
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 EPHA4 INSRR

8.21e-067804710GO:0042327
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

ZDHHC7 LAMC1 SPRY2 IGF1R EGFR FST ITGB1 ITGB3 EPHA4

9.16e-06619479GO:0002009
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

VWC2L SPRY2 ADAM17 BMPER CHRDL2 FST

9.73e-06218476GO:0090101
GeneOntologyBiologicalProcessregulation of transferase activity

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB3 SPRY4 EPHA4 INSRR

1.14e-058104710GO:0051338
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

VWC2L SPRY2 ADAM17 LTBP3 BMPER CHRDL2 FST ITGB1

1.18e-05482478GO:0007178
GeneOntologyBiologicalProcessregulation of MAPK cascade

SPRY2 TRAF2 ADAM17 IGF1R MT3 BMPER EGFR ITGB3 SPRY4 EPHA4

1.20e-058154710GO:0043408
GeneOntologyBiologicalProcesspositive regulation of transferase activity

TRAF2 ADAM17 IGF1R MT3 EGFR ITGB3 EPHA4 INSRR

1.33e-05490478GO:0051347
GeneOntologyBiologicalProcessregulation of postsynaptic neurotransmitter receptor diffusion trapping

ITGB1 ITGB3

1.52e-053472GO:0150054
GeneOntologyBiologicalProcesspositive regulation of ERK1 and ERK2 cascade

SPRY2 ADAM17 MT3 BMPER EGFR ITGB3

1.68e-05240476GO:0070374
GeneOntologyBiologicalProcessnegative regulation of cellular response to growth factor stimulus

VWC2L SPRY2 BMPER CHRDL2 SPRY4

2.28e-05150475GO:0090288
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 EPHA4 INSRR

2.31e-058794710GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 EPHA4 INSRR

2.31e-058794710GO:0010562
GeneOntologyBiologicalProcessregulation of ERK1 and ERK2 cascade

SPRY2 ADAM17 MT3 BMPER EGFR ITGB3 EPHA4

2.47e-05385477GO:0070372
GeneOntologyBiologicalProcesspositive regulation of bone resorption

LTBP3 EGFR ITGB3

3.49e-0528473GO:0045780
GeneOntologyBiologicalProcessMAPK cascade

SPRY2 TRAF2 ADAM17 IGF1R MT3 BMPER EGFR ITGB3 SPRY4 EPHA4

3.74e-059304710GO:0000165
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

VWC2L CCN6 NELL1 LAMC1 LTBP3 EGFR FEZF1 ITGB1 ITGB3 ZNF268 EPHA4

3.91e-0511414711GO:0045597
GeneOntologyBiologicalProcessERK1 and ERK2 cascade

SPRY2 ADAM17 MT3 BMPER EGFR ITGB3 EPHA4

4.17e-05418477GO:0070371
GeneOntologyBiologicalProcesstissue morphogenesis

ZDHHC7 LAMC1 SPRY2 IGF1R EGFR FST ITGB1 ITGB3 EPHA4

4.17e-05750479GO:0048729
GeneOntologyBiologicalProcesssex determination

IGF1R ZNF726 INSRR

4.77e-0531473GO:0007530
GeneOntologyBiologicalProcessregulation of osteoblast proliferation

NELL1 IGF1R ITGB3

6.31e-0534473GO:0033688
GeneOntologyBiologicalProcessregulation of protein kinase activity

SPRY2 TRAF2 ADAM17 MT3 EGFR ITGB3 SPRY4 EPHA4

6.42e-05611478GO:0045859
GeneOntologyBiologicalProcessregulation of phosphorylation

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 SPRY4 EPHA4 INSRR

7.50e-0512264711GO:0042325
GeneOntologyBiologicalProcessregulation of MAP kinase activity

SPRY2 TRAF2 EGFR SPRY4 EPHA4

7.78e-05194475GO:0043405
GeneOntologyBiologicalProcesscell projection morphogenesis

LAMC1 ADAM17 IGF1R MT3 EGFR FEZF1 ITGB1 ITGB3 EPHA4

8.79e-05826479GO:0048858
GeneOntologyBiologicalProcesspeptidyl-tyrosine phosphorylation

ADAM17 IGF1R EGFR ITGB1 ITGB3 EPHA4

9.42e-05327476GO:0018108
GeneOntologyBiologicalProcesspeptidyl-tyrosine modification

ADAM17 IGF1R EGFR ITGB1 ITGB3 EPHA4

9.74e-05329476GO:0018212
GeneOntologyBiologicalProcessregulation of axon regeneration

ADAM17 IGF1R EPHA4

1.03e-0440473GO:0048679
GeneOntologyBiologicalProcessosteoblast proliferation

NELL1 IGF1R ITGB3

1.11e-0441473GO:0033687
GeneOntologyBiologicalProcesspositive regulation of intracellular signal transduction

TSPAN6 SPRY2 TRAF2 ADAM17 IGF1R MT3 BMPER EGFR ITGB1 ITGB3 EPHA4

1.26e-0412994711GO:1902533
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

VWC2L SPRY2 ADAM17 BMPER CHRDL2 FST

1.30e-04347476GO:0090092
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

TRAF2 ADAM17 MT3 EGFR ITGB3 EPHA4

1.37e-04350476GO:0045860
GeneOntologyBiologicalProcessregulation of fibroblast growth factor receptor signaling pathway

SPRY2 ITGB1 SPRY4

1.38e-0444473GO:0040036
GeneOntologyBiologicalProcesspositive regulation of cell migration

SPRY2 ADAM17 IGF1R EGFR ITGB1 ITGB3 ZNF268 EPHA4

1.51e-04691478GO:0030335
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

SPRY2 TRAF2 ADAM17 EGFR SPRY4 EPHA4

1.54e-04358476GO:0071900
GeneOntologyBiologicalProcessregulation of neuron projection regeneration

ADAM17 IGF1R EPHA4

1.68e-0447473GO:0070570
GeneOntologyBiologicalProcessnegative regulation of cell projection organization

SPRY2 ADAM17 MT3 ITGB1 EPHA4

1.84e-04233475GO:0031345
GeneOntologyBiologicalProcessnegative regulation of apoptotic process

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 ZNF268 EPHA4

1.93e-0411334710GO:0043066
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

SPRY2 TRAF2 ADAM17 MT3 EGFR ITGB1 ITGB3 EPHA4

2.07e-04724478GO:0001934
GeneOntologyBiologicalProcesspositive regulation of cell motility

SPRY2 ADAM17 IGF1R EGFR ITGB1 ITGB3 ZNF268 EPHA4

2.09e-04725478GO:2000147
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

VWC2L BMPER CHRDL2 FST

2.24e-04131474GO:0030510
GeneOntologyBiologicalProcesspositive regulation of locomotion

SPRY2 ADAM17 IGF1R EGFR ITGB1 ITGB3 ZNF268 EPHA4

2.45e-04742478GO:0040017
GeneOntologyBiologicalProcessnegative regulation of programmed cell death

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 ZNF268 EPHA4

2.53e-0411714710GO:0043069
GeneOntologyBiologicalProcessaxonogenesis

LAMC1 ADAM17 IGF1R MT3 FEZF1 ITGB1 EPHA4

2.74e-04566477GO:0007409
GeneOntologyBiologicalProcessregulation of synapse pruning

ITGB1 EPHA4

2.76e-0411472GO:1905806
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 SPRY4 EPHA4 INSRR

2.76e-0414214711GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

SPRY2 TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 SPRY4 EPHA4 INSRR

2.80e-0414234711GO:0051174
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

ZDHHC7 SPRY2 ADAM17 IGF1R UHRF2 EGFR ITGB1 ITGB3 EPHA4

3.08e-04976479GO:0018193
GeneOntologyBiologicalProcessregulation of peptidyl-tyrosine phosphorylation

ADAM17 EGFR ITGB1 ITGB3 EPHA4

3.75e-04272475GO:0050730
GeneOntologyBiologicalProcessneurotransmitter receptor diffusion trapping

ITGB1 ITGB3

3.90e-0413472GO:0099628
GeneOntologyBiologicalProcesspostsynaptic neurotransmitter receptor diffusion trapping

ITGB1 ITGB3

3.90e-0413472GO:0098970
GeneOntologyBiologicalProcesscellular response to insulin-like growth factor stimulus

IGF1R ITGB3

3.90e-0413472GO:1990314
GeneOntologyBiologicalProcessneuron projection morphogenesis

LAMC1 ADAM17 IGF1R MT3 EGFR FEZF1 ITGB1 EPHA4

4.13e-04802478GO:0048812
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

TRAF2 ADAM17 IGF1R MT3 EGFR ITGB1 ITGB3 EPHA4 INSRR

4.51e-041028479GO:0043085
GeneOntologyBiologicalProcessreceptor diffusion trapping

ITGB1 ITGB3

4.54e-0414472GO:0098953
GeneOntologyBiologicalProcesspositive regulation of tumor necrosis factor-mediated signaling pathway

TRAF2 ADAM17

4.54e-0414472GO:1903265
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

LAMC1 ADAM17 IGF1R MT3 EGFR FEZF1 ITGB1 EPHA4

4.75e-04819478GO:0120039
GeneOntologyBiologicalProcessnegative regulation of small GTPase mediated signal transduction

SPRY2 ITGB1 SPRY4

4.80e-0467473GO:0051058
GeneOntologyBiologicalProcessaxon regeneration

ADAM17 IGF1R EPHA4

5.23e-0469473GO:0031103
GeneOntologyBiologicalProcessregulation of protein tyrosine kinase activity

ADAM17 ITGB3 EPHA4

5.23e-0469473GO:0061097
GeneOntologyBiologicalProcesspositive regulation of osteoblast proliferation

IGF1R ITGB3

5.24e-0415472GO:0033690
GeneOntologyBiologicalProcessregulation of bone resorption

LTBP3 EGFR ITGB3

5.45e-0470473GO:0045124
GeneOntologyBiologicalProcessaxon development

LAMC1 ADAM17 IGF1R MT3 FEZF1 ITGB1 EPHA4

5.84e-04642477GO:0061564
GeneOntologyBiologicalProcessmale sex determination

IGF1R INSRR

5.98e-0416472GO:0030238
GeneOntologyBiologicalProcesscellular response to mechanical stimulus

IGF1R EGFR ITGB3

6.17e-0473473GO:0071260
GeneOntologyBiologicalProcesscellular response to external stimulus

IGF1R EGFR ITGB3

6.42e-0474473GO:0071496
GeneOntologyBiologicalProcessmaintenance of postsynaptic specialization structure

ITGB1 ITGB3

6.76e-0417472GO:0098880
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

SPRY2 LTBP3 MT3 EGFR FST ITGB1 ITGB3 EPHA4

7.34e-04875478GO:0045596
GeneOntologyBiologicalProcessnegative regulation of BMP signaling pathway

VWC2L BMPER CHRDL2

8.06e-0480473GO:0030514
GeneOntologyBiologicalProcessregulation of bone remodeling

LTBP3 EGFR ITGB3

8.06e-0480473GO:0046850
GeneOntologyBiologicalProcessneuron projection regeneration

ADAM17 IGF1R EPHA4

8.35e-0481473GO:0031102
GeneOntologyBiologicalProcesssynapse pruning

ITGB1 EPHA4

8.48e-0419472GO:0098883
GeneOntologyBiologicalProcessregulation of protein phosphorylation

SPRY2 TRAF2 ADAM17 MT3 EGFR ITGB1 ITGB3 SPRY4 EPHA4

9.07e-041133479GO:0001932
GeneOntologyBiologicalProcessanatomical structure homeostasis

LAMC1 LTBP3 EGFR ITGB1 ITGB3

9.49e-04334475GO:0060249
GeneOntologyBiologicalProcesstissue homeostasis

LAMC1 LTBP3 EGFR ITGB1 ITGB3

9.49e-04334475GO:0001894
GeneOntologyBiologicalProcesspositive regulation of peptidyl-tyrosine phosphorylation

ADAM17 ITGB1 ITGB3 EPHA4

9.68e-04193474GO:0050731
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

TRAF2 ADAM17 EGFR EPHA4

9.68e-04193474GO:0071902
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

SPRY2 ADAM17 LTBP3 IGF1R ITGB1

9.75e-04336475GO:0071560
GeneOntologyBiologicalProcessregulation of epidermal growth factor receptor signaling pathway

SPRY2 ADAM17 EGFR

9.94e-0486473GO:0042058
GeneOntologyBiologicalProcessBMP signaling pathway

VWC2L BMPER CHRDL2 FST

1.04e-03197474GO:0030509
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

SPRY2 ADAM17 LTBP3 IGF1R ITGB1

1.07e-03343475GO:0071559
GeneOntologyBiologicalProcessnegative regulation of MAPK cascade

SPRY2 IGF1R SPRY4 EPHA4

1.12e-03201474GO:0043409
GeneOntologyBiologicalProcesspeptidyl-tyrosine autophosphorylation

IGF1R EGFR

1.14e-0322472GO:0038083
GeneOntologyBiologicalProcesspositive regulation of protein modification process

SPRY2 TRAF2 ADAM17 MT3 EGFR ITGB1 ITGB3 EPHA4

1.14e-03937478GO:0031401
GeneOntologyBiologicalProcesscell adhesion mediated by integrin

ADAM17 ITGB1 ITGB3

1.17e-0391473GO:0033627
GeneOntologyBiologicalProcessregulation of ERBB signaling pathway

SPRY2 ADAM17 EGFR

1.25e-0393473GO:1901184
GeneOntologyBiologicalProcessnegative regulation of gene expression via chromosomal CpG island methylation

UHRF2 ZNF726

1.25e-0323472GO:0044027
GeneOntologyBiologicalProcesspositive regulation of vascular endothelial growth factor receptor signaling pathway

MT3 ITGB3

1.25e-0323472GO:0030949
GeneOntologyBiologicalProcesspositive regulation of cell population proliferation

LAMC1 ADAM17 LTBP3 IGF1R EGFR ITGB1 ITGB3 ZNF268 EPHA4

1.28e-031190479GO:0008284
GeneOntologyCellularComponentruffle membrane

SPRY2 ADAM17 EGFR ITGB1 ITGB3 SPRY4

1.49e-07108476GO:0032587
GeneOntologyCellularComponentruffle

SPRY2 ADAM17 EGFR ITGB1 ITGB3 SPRY4

6.53e-06206476GO:0001726
GeneOntologyCellularComponentleading edge membrane

SPRY2 ADAM17 EGFR ITGB1 ITGB3 SPRY4

7.29e-06210476GO:0031256
GeneOntologyCellularComponentintegrin alpha9-beta1 complex

ITGB1 ITGB3

1.48e-053472GO:0034679
GeneOntologyCellularComponentalphav-beta3 integrin-IGF-1-IGF1R complex

IGF1R ITGB3

2.96e-054472GO:0035867
GeneOntologyCellularComponentinsulin receptor complex

IGF1R INSRR

2.96e-054472GO:0005899
GeneOntologyCellularComponentplasma membrane signaling receptor complex

VWC2L TRAF2 IGF1R ITGB1 ITGB3 INSRR

1.27e-04350476GO:0098802
GeneOntologyCellularComponentreceptor complex

VWC2L TRAF2 IGF1R EGFR ITGB1 ITGB3 INSRR

2.96e-04581477GO:0043235
GeneOntologyCellularComponentprotein complex involved in cell adhesion

LAMC1 ITGB1 ITGB3

3.17e-0459473GO:0098636
GeneOntologyCellularComponentcell projection membrane

SPRY2 ADAM17 EGFR ITGB1 ITGB3 SPRY4

3.90e-04431476GO:0031253
GeneOntologyCellularComponentfocal adhesion

ADAM17 TES EGFR ITGB1 ITGB3 SPRY4

3.90e-04431476GO:0005925
GeneOntologyCellularComponentcell-substrate junction

ADAM17 TES EGFR ITGB1 ITGB3 SPRY4

4.51e-04443476GO:0030055
GeneOntologyCellularComponentcell leading edge

SPRY2 ADAM17 EGFR ITGB1 ITGB3 SPRY4

8.49e-04500476GO:0031252
GeneOntologyCellularComponentglycinergic synapse

ITGB1 ITGB3

9.16e-0420472GO:0098690
GeneOntologyCellularComponentmembrane raft

TRAF2 ADAM17 IGF1R EGFR ITGB1

1.28e-03362475GO:0045121
GeneOntologyCellularComponentmembrane microdomain

TRAF2 ADAM17 IGF1R EGFR ITGB1

1.31e-03364475GO:0098857
GeneOntologyCellularComponentplasma membrane protein complex

VWC2L TRAF2 IGF1R EGFR ITGB1 ITGB3 INSRR

1.74e-03785477GO:0098797
GeneOntologyCellularComponentneuromuscular junction

LAMC1 ITGB1 EPHA4

2.05e-03112473GO:0031594
GeneOntologyCellularComponentintegrin complex

ITGB1 ITGB3

2.35e-0332472GO:0008305
GeneOntologyCellularComponentfilopodium

ITGB1 ITGB3 EPHA4

2.67e-03123473GO:0030175
GeneOntologyCellularComponentextracellular matrix

CCN6 LAMC1 PI3 LTBP3 BMPER ITGB1

3.36e-03656476GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

CCN6 LAMC1 PI3 LTBP3 BMPER ITGB1

3.41e-03658476GO:0030312
GeneOntologyCellularComponentglial cell projection

MT3 ITGB1

5.01e-0347472GO:0097386
GeneOntologyCellularComponentanchoring junction

ADAM17 TES EGFR ITGB1 ITGB3 SPRY4 EPHA4

5.82e-03976477GO:0070161
HumanPhenoOtitis externa

ADAM17 EGFR

1.27e-053112HP:0410017
HumanPhenoPerianal dermatitis

ADAM17 EGFR

1.27e-053112HP:0011131
HumanPhenoChronic monilial nail infection

ADAM17 EGFR

1.27e-053112HP:0008396
HumanPhenoSlow-growing scalp hair

ADAM17 EGFR

2.54e-054112HP:0100038
HumanPhenoChapped lip

ADAM17 EGFR

2.54e-054112HP:0040181
HumanPhenoAnal fissure

ADAM17 EGFR

4.22e-055112HP:0012390
HumanPhenoBloody diarrhea

ADAM17 EGFR ITGB3

1.39e-0450113HP:0025085
HumanPhenoRecurrent gastroenteritis

ADAM17 EGFR

3.80e-0414112HP:0031123
HumanPhenoSkeletal dysplasia

CCN6 LTBP3 FEZF1 SPRY4

4.64e-04186114HP:0002652
MousePhenorespiratory failure

NELL1 ADAM17 IGF1R BMPER EGFR FST

3.59e-06165366MP:0001953
MousePhenodecreased respiration

NELL1 ADAM17 IGF1R BMPER EGFR FST

4.26e-06170366MP:0014274
MousePhenothick lung-associated mesenchyme

LAMC1 ADAM17 BMPER

1.74e-0520363MP:0011143
MousePhenodecreased fetal size

LAMC1 ADAM17 BMPER EGFR FST ITGB1

2.34e-05229366MP:0004200
MousePhenoabnormal fetal size

LAMC1 ADAM17 BMPER EGFR FST ITGB1

2.84e-05237366MP:0004198
MousePhenoabnormal lung saccule morphology

LAMC1 ADAM17 BMPER

5.47e-0529363MP:0010825
MousePhenoperinatal lethality

NELL1 LAMC1 TRAF2 ADAM17 IGF1R BMPER EGFR FST FEZF1 ITGB1 ITGB3

8.32e-0511303611MP:0002081
MousePhenoabnormal branching involved in lung morphogenesis

ADAM17 BMPER EGFR

8.89e-0534363MP:0011024
MousePhenocornea scarring

ADAM17 EGFR

9.61e-056362MP:0001316
MousePhenoabnormal skeleton development

NELL1 SPRY2 ADAM17 LTBP3 BMPER EGFR FST

1.22e-04447367MP:0002113
MousePhenoabnormal fetal growth/weight/body size

LAMC1 ADAM17 BMPER EGFR FST ITGB1

1.30e-04312366MP:0004197
MousePhenoenlarged frontal bone

NELL1 SPRY2

1.34e-047362MP:0004375
MousePhenoenlarged interparietal bone

NELL1 SPRY2

1.34e-047362MP:0004386
MousePhenoabnormal nose morphology

NELL1 SPRY2 LTBP3 FST FEZF1

1.53e-04201365MP:0002233
MousePhenoabnormal cranium morphology

NELL1 SPRY2 LTBP3 IGF1R BMPER EGFR FST ITGB1 SPRY4

1.65e-04813369MP:0000438
MousePhenoenlarged aortic valve

ADAM17 EGFR

1.79e-048362MP:0010591
MousePhenoabnormal craniofacial bone morphology

NELL1 SPRY2 LTBP3 IGF1R BMPER EGFR FST ITGB1 SPRY4

1.88e-04827369MP:0002116
MousePhenoabnormal respiratory system morphology

NELL1 LAMC1 SPRY2 ADAM17 LTBP3 IGF1R BMPER EGFR FST FEZF1

1.91e-0410273610MP:0002132
MousePhenoabnormal cartilage morphology

NELL1 SPRY2 ADAM17 LTBP3 BMPER EGFR

1.95e-04336366MP:0000163
MousePhenosmall supraoccipital bone

SPRY2 BMPER

2.30e-049362MP:0004444
MousePhenodistorted hair follicle pattern

ADAM17 EGFR

2.30e-049362MP:0000384
MousePhenolethality during fetal growth through weaning, complete penetrance

NELL1 LAMC1 TRAF2 ADAM17 IGF1R BMPER EGFR FST FEZF1 ITGB1 ARIH2

2.35e-0412693611MP:0011111
MousePhenomalocclusion

SPRY2 LTBP3 SPRY4

2.35e-0447363MP:0000120
MousePhenoabnormal interparietal bone morphology

NELL1 SPRY2 BMPER

2.51e-0448363MP:0000077
MousePhenocyanosis

ADAM17 IGF1R EGFR FST ITGB1

2.65e-04226365MP:0001575
MousePhenoabnormal respiratory epithelium morphology

ADAM17 BMPER EGFR FST FEZF1

3.17e-04235365MP:0010942
MousePhenomisaligned teeth

SPRY2 LTBP3 SPRY4

3.18e-0452363MP:0030540
MousePhenodecreased skeletal muscle mass

LAMC1 TRAF2 FST ITGB1

3.44e-04131364MP:0004819
MousePhenopetechiae

EGFR ITGB3

3.50e-0411362MP:0008816
MousePhenoenlarged semilunar valve

ADAM17 EGFR

3.50e-0411362MP:0031580
MousePhenoperinatal lethality, complete penetrance

NELL1 LAMC1 ADAM17 IGF1R BMPER EGFR FST FEZF1

3.70e-04712368MP:0011089
MousePhenoabnormal facial morphology

NELL1 SPRY2 LTBP3 EGFR FST FEZF1 ITGB1 NSD3 SPRY4

3.84e-04910369MP:0003743
MousePhenoabnormal tooth number

SPRY2 FST SPRY4

3.96e-0456363MP:0030611
MousePhenocraniofacial phenotype

NELL1 SPRY2 LTBP3 IGF1R BMPER EGFR FST FEZF1 ITGB1 NSD3 SPRY4

4.64e-0413723611MP:0005382
MousePhenoabnormal craniofacial morphology

NELL1 SPRY2 LTBP3 IGF1R BMPER EGFR FST FEZF1 ITGB1 NSD3 SPRY4

4.64e-0413723611MP:0000428
MousePhenoabnormal lung development

LAMC1 ADAM17 BMPER EGFR

4.67e-04142364MP:0001176
MousePhenoabnormal oxygen level

ADAM17 IGF1R EGFR FST ITGB1

4.69e-04256365MP:0001574
MousePhenosupernumerary teeth

SPRY2 SPRY4

4.94e-0413362MP:0004033
MousePhenoabnormal skeletal muscle mass

LAMC1 TRAF2 FST ITGB1

5.60e-04149364MP:0004817
MousePhenoosteosclerosis

LTBP3 ITGB3

5.75e-0414362MP:0005422
MousePhenoabnormal neurocranium morphology

NELL1 SPRY2 LTBP3 IGF1R BMPER

5.88e-04269365MP:0000074
MousePhenoabnormal temporal bone morphology

SPRY2 IGF1R BMPER

6.42e-0466363MP:0005272
MousePhenoabnormal esophagus morphology

SPRY2 ADAM17 EGFR

6.42e-0466363MP:0000467
MousePhenoabnormal transforming growth factor beta level

ADAM17 ITGB3

6.63e-0415362MP:0008836
MousePhenoabnormal viscerocranium morphology

NELL1 SPRY2 LTBP3 EGFR FST ITGB1 SPRY4

6.81e-04593367MP:0005274
MousePhenoabnormal craniofacial development

SPRY2 LTBP3 BMPER EGFR FST ITGB1

6.85e-04425366MP:0003935
MousePhenoabnormal gas homeostasis

ADAM29 ADAM17 LTBP3 IGF1R EGFR FST ITGB1

7.30e-04600367MP:0003948
MousePhenodermatitis

ADAM17 ITGB3 ARIH2

7.31e-0469363MP:0001194
MousePhenoabnormal respiratory system development

LAMC1 ADAM17 BMPER EGFR

7.32e-04160364MP:0003115
MousePhenodilated respiratory conducting tube

ADAM17 EGFR

8.56e-0417362MP:0010856
MousePhenoabnormal cartilage development

NELL1 ADAM17 LTBP3 BMPER

9.59e-04172364MP:0000164
MousePhenoabnormal frontal bone morphology

NELL1 SPRY2 LTBP3

1.01e-0377363MP:0000107
MousePhenoabnormal mandible morphology

SPRY2 EGFR ITGB1 SPRY4

1.04e-03176364MP:0000458
MousePhenosmall vertebral body

SPRY2 BMPER

1.07e-0319362MP:0004670
MousePhenoabnormal hair follicle orientation

ADAM17 EGFR

1.07e-0319362MP:0000383
MousePhenoabnormal respiratory conducting tube morphology

LAMC1 ADAM17 EGFR

1.08e-0379363MP:0004391
MousePhenodecreased spongiotrophoblast size

ADAM17 EGFR

1.19e-0320362MP:0012099
MousePhenoshort vibrissae

ADAM17 EGFR

1.19e-0320362MP:0001282
MousePhenoabnormal bronchiole epithelium morphology

ADAM17 EGFR

1.19e-0320362MP:0010897
MousePhenofailure of eyelid fusion

ADAM17 EGFR

1.19e-0320362MP:0009264
MousePhenodecreased eosinophil cell number

ZNF729 ZNF493 ZNF43

1.30e-0384363MP:0005012
MousePhenodecreased cornea thickness

ADAM17 EGFR

1.31e-0321362MP:0005543
MousePhenosmall interparietal bone

NELL1 BMPER

1.31e-0321362MP:0004384
MousePhenoabnormal induced retina neovascularization

BMPER ITGB3

1.31e-0321362MP:0009660
MousePhenowaved hair

ADAM17 EGFR

1.31e-0321362MP:0000410
MousePhenoabnormal cartilaginous joint morphology

NELL1 LTBP3 BMPER

1.34e-0385363MP:0030875
MousePhenopostnatal lethality, incomplete penetrance

SPRY2 TRAF2 ADAM17 EGFR ITGB3 SPRY4 ARIH2

1.38e-03669367MP:0011086
MousePhenoabnormal placenta labyrinth morphology

TRAF2 EGFR ITGB1 ITGB3

1.50e-03194364MP:0001716
MousePhenoperinatal lethality, incomplete penetrance

TRAF2 ADAM17 EGFR FEZF1 ITGB1 ITGB3

1.64e-03503366MP:0011090
MousePhenoabnormal head morphology

NELL1 SPRY2 LTBP3 EGFR FST FEZF1 ITGB1 NSD3 SPRY4

1.71e-031120369MP:0000432
MousePhenolethality during fetal growth through weaning, incomplete penetrance

SPRY2 TRAF2 ADAM17 EGFR FEZF1 ITGB1 ITGB3 SPRY4 ARIH2

1.75e-031124369MP:0011112
MousePhenoabnormal occipital bone morphology

SPRY2 LTBP3 BMPER

1.85e-0395363MP:0005269
MousePhenoabnormal olfactory sensory neuron morphology

FST FEZF1

1.86e-0325362MP:0006092
MousePhenoabnormal quadriceps morphology

LAMC1 FST

1.86e-0325362MP:0010225
MousePhenocurly vibrissae

ADAM17 EGFR

2.02e-0326362MP:0001274
MousePhenoabnormal trophoblast layer morphology

ADAM17 EGFR ITGB1 ITGB3

2.04e-03211364MP:0005031
MousePhenoabnormal jaw morphology

SPRY2 LTBP3 EGFR FST ITGB1 SPRY4

2.13e-03530366MP:0000454
MousePhenothick aortic valve

ADAM17 EGFR

2.17e-0327362MP:0010594
MousePhenomaternal imprinting

ZNF355P ZNF726

2.34e-0328362MP:0003122
MousePhenoabnormal spongiotrophoblast size

ADAM17 EGFR

2.34e-0328362MP:0012097
MousePhenoshort facial bone

SPRY2 LTBP3 EGFR

2.39e-03104363MP:0030384
MousePhenoskin inflammation

ADAM17 ITGB3 ARIH2

2.46e-03105363MP:0004947
MousePhenoabnormal supraoccipital bone morphology

SPRY2 BMPER

2.51e-0329362MP:0000078
MousePhenoenhanced wound healing

ADAM29 ITGB3

2.51e-0329362MP:0002724
MousePhenoabnormal eyelid fusion

ADAM17 EGFR

2.51e-0329362MP:0009263
MousePhenoabnormal presacral vertebrae morphology

NELL1 LTBP3 BMPER FST

2.57e-03225364MP:0000459
MousePhenoabnormal tooth development

SPRY2 LTBP3 FST

2.66e-03108363MP:0000116
MousePhenopathological neovascularization

ADAM17 BMPER ITGB3

2.66e-03108363MP:0003711
MousePhenoabnormal chemoreceptor morphology

FST FEZF1

2.68e-0330362MP:0001001
Domainzf-C2H2_6

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 FEZF1 ZNF43 ZNF726 ZNF728 ZNF77

5.64e-133144713PF13912
DomainZINC_FINGER_C2H2_2

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 ZC3H7B FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

3.54e-107754715PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 ZC3H7B FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

3.67e-107774715PS00028
DomainZnf_C2H2-like

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 ZC3H7B FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

5.12e-107964715IPR015880
DomainZnf_C2H2

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 ZC3H7B FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

5.98e-108054715IPR007087
DomainZnF_C2H2

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 ZC3H7B FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

6.30e-108084715SM00355
Domain-

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

6.94e-1067947143.30.160.60
Domainzf-C2H2

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

9.04e-106934714PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

9.21e-106944714IPR013087
DomainKRAB

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF229 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

1.03e-093584711PS50805
DomainKRAB

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF229 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

1.03e-093584711PF01352
DomainKRAB

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF229 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

1.42e-093694711SM00349
DomainKRAB

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF229 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

1.46e-093704711IPR001909
DomainGrowth_fac_rcpt_

CCN6 NELL1 LAMC1 LTBP3 IGF1R EGFR INSRR

1.18e-07156477IPR009030
DomainFurin-like

IGF1R EGFR INSRR

5.19e-077473PF00757
DomainRcpt_L-dom

IGF1R EGFR INSRR

5.19e-077473IPR000494
DomainFurin-like_Cys-rich_dom

IGF1R EGFR INSRR

5.19e-077473IPR006211
DomainRecep_L_domain

IGF1R EGFR INSRR

5.19e-077473PF01030
Domain-

IGF1R EGFR INSRR

5.19e-0774733.80.20.20
DomainVWFC_1

VWC2L NELL1 BMPER CHRDL2

1.95e-0636474PS01208
DomainVWC

VWC2L NELL1 BMPER CHRDL2

2.44e-0638474SM00214
DomainVWFC_2

VWC2L NELL1 BMPER CHRDL2

2.44e-0638474PS50184
DomainVWF_dom

VWC2L NELL1 BMPER CHRDL2

3.67e-0642474IPR001007
DomainEGF-like_CS

NELL1 LAMC1 ADAM29 ADAM17 LTBP3 ITGB1 ITGB3

3.75e-06261477IPR013032
DomainFurin_repeat

IGF1R EGFR INSRR

1.19e-0518473IPR006212
DomainFU

IGF1R EGFR INSRR

1.19e-0518473SM00261
DomainTyr_kinase_insulin-like_rcpt

IGF1R INSRR

1.86e-053472IPR016246
DomainWAP_dom

WFDC3 PI3 MT3

2.22e-0522473IPR008197
Domain-

ITGB1 ITGB3

3.71e-0544721.20.5.630
DomainEGF_1

NELL1 LAMC1 ADAM29 LTBP3 ITGB1 ITGB3

4.10e-05255476PS00022
DomainVWC

NELL1 BMPER CHRDL2

4.68e-0528473PF00093
DomainTyrKc

IGF1R EGFR EPHA4 INSRR

7.03e-0588474SM00219
DomainTyr_kinase_cat_dom

IGF1R EGFR EPHA4 INSRR

7.03e-0588474IPR020635
DomainIntegrin_bsu_cyt_dom

ITGB1 ITGB3

9.24e-056472IPR014836
DomainIntegrin_b_cyt

ITGB1 ITGB3

9.24e-056472SM01241
DomainIntegrin_b_cyt

ITGB1 ITGB3

9.24e-056472PF08725
DomainPROTEIN_KINASE_TYR

IGF1R EGFR EPHA4 INSRR

1.03e-0497474PS00109
DomainTyr_kinase_AS

IGF1R EGFR EPHA4 INSRR

1.03e-0497474IPR008266
DomainSPR

SPRY2 SPRY4

1.29e-047472PS51227
DomainSprouty

SPRY2 SPRY4

1.29e-047472IPR007875
DomainIntegrin_bsu_tail

ITGB1 ITGB3

1.29e-047472IPR012896
DomainIntegrin_B_tail

ITGB1 ITGB3

1.29e-047472SM01242
DomainSprouty

SPRY2 SPRY4

1.29e-047472PF05210
DomainIntegrin_B_tail

ITGB1 ITGB3

1.29e-047472PF07965
DomainINB

ITGB1 ITGB3

1.72e-048472SM00187
DomainIntegrin_beta

ITGB1 ITGB3

1.72e-048472PF00362
DomainIntegrin_bsu_VWA

ITGB1 ITGB3

1.72e-048472IPR002369
DomainTB

LTBP3 FST

2.21e-049472PS51364
DomainIntegrin_bsu

ITGB1 ITGB3

2.21e-049472IPR015812
DomainTB_dom

LTBP3 FST

2.21e-049472IPR017878
DomainINTEGRIN_BETA

ITGB1 ITGB3

2.21e-049472PS00243
DomainPSI_integrin

ITGB1 ITGB3

2.21e-049472PF17205
DomainIntegin_beta_N

ITGB1 ITGB3

2.21e-049472IPR033760
DomainE3_UB_ligase_RBR

RNF144A ARIH2

2.75e-0410472IPR031127
DomainPkinase_Tyr

IGF1R EGFR EPHA4 INSRR

3.08e-04129474PF07714
DomainTyr_kinase_rcpt_2_CS

IGF1R INSRR

3.36e-0411472IPR002011
DomainSer-Thr/Tyr_kinase_cat_dom

IGF1R EGFR EPHA4 INSRR

3.98e-04138474IPR001245
DomainRECEPTOR_TYR_KIN_II

IGF1R INSRR

4.03e-0412472PS00239
DomainEGF_extracell

NELL1 ITGB1 ITGB3

4.62e-0460473IPR013111
DomainEGF_2

NELL1 ITGB1 ITGB3

4.62e-0460473PF07974
DomainEGF_2

NELL1 LAMC1 ADAM29 LTBP3 ITGB3

5.22e-04265475PS01186
DomainIBR

RNF144A ARIH2

5.53e-0414472PF01485
DomainIBR

RNF144A ARIH2

5.53e-0414472SM00647
DomainIBR_dom

RNF144A ARIH2

6.37e-0415472IPR002867
DomainWAP

WFDC3 PI3

7.27e-0416472SM00217
DomainWAP

WFDC3 PI3

7.27e-0416472PF00095
DomainZnf_RING_CS

TRAF2 UHRF2 RNF144A ARIH2

7.45e-04163474IPR017907
Domain-

WFDC3 PI3

8.23e-04174724.10.75.10
DomainWAP

WFDC3 PI3

8.23e-0417472PS51390
DomainRING

TRAF2 UHRF2 RNF144A NSD3 ARIH2

9.83e-04305475SM00184
Domain-

ADAM29 ADAM17

1.14e-03204724.10.70.10
DomainDISIN

ADAM29 ADAM17

1.26e-0321472SM00050
DomainDisintegrin

ADAM29 ADAM17

1.26e-0321472PF00200
DomainZnf_RING

TRAF2 UHRF2 RNF144A NSD3 ARIH2

1.32e-03326475IPR001841
DomainIntegrin_dom

ITGB1 ITGB3

1.79e-0325472IPR032695
PathwayWP_TROP2_REGULATORY_SIGNALING

ADAM17 IGF1R EGFR ITGB1

5.53e-0649344M46458
PathwayBIOCARTA_SPRY_PATHWAY

SPRY2 EGFR SPRY4

7.03e-0616343MM1500
PathwayBIOCARTA_SPRY_PATHWAY

SPRY2 EGFR SPRY4

8.52e-0617343M1389
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF729 ZNF823 ZNF355P ZNF490 ZNF778 ZNF799 ZNF493 ZNF43 ZNF268 ZNF726

8.62e-067683410MM14851
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

EGFR ITGB1 ITGB3

1.21e-0519343MM15113
PathwayWP_EBOLA_VIRUS_INFECTION_IN_HOST

ADAM17 IGF1R EGFR ITGB1 ITGB3

1.34e-05129345M39693
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

EGFR ITGB1 ITGB3

1.66e-0521343M878
PathwayBIOCARTA_ERK_PATHWAY

IGF1R EGFR ITGB1

3.60e-0527343M287
PathwayBIOCARTA_ERK_PATHWAY

IGF1R EGFR ITGB1

4.03e-0528343MM1391
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP3 ITGB1 ITGB3

6.06e-0532343MM14854
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP3 ITGB1 ITGB3

9.42e-0537343M27134
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ZNF729 ZNF823 ZNF355P ZNF490 ZNF778 ZNF799 ZNF493 ZNF43 ZNF268 ZNF726

1.01e-0410223410MM15436
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP3 ITGB1 ITGB3

1.02e-0438343MM14874
PathwayWP_FOCAL_ADHESION

LAMC1 IGF1R EGFR ITGB1 ITGB3

1.06e-04199345M39402
PathwayKEGG_FOCAL_ADHESION

LAMC1 IGF1R EGFR ITGB1 ITGB3

1.06e-04199345M7253
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP3 ITGB1 ITGB3

1.10e-0439343MM14601
PathwayPID_UPA_UPAR_PATHWAY

EGFR ITGB1 ITGB3

1.38e-0442343M174
PathwayBIOCARTA_EPHA4_PATHWAY

ITGB1 EPHA4

1.57e-048342M16334
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP3 ITGB1 ITGB3

1.59e-0444343M26969
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

LTBP3 FST ITGB1 ITGB3

1.78e-04118344MM15588
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

LAMC1 EGFR ITGB1

1.81e-0446343M239
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP3 ITGB1 ITGB3

1.93e-0447343M646
PathwayREACTOME_L1CAM_INTERACTIONS

LAMC1 EGFR ITGB1 ITGB3

1.96e-04121344M872
PathwayWP_HIPPOMERLIN_SIGNALING_DYSREGULATION

IGF1R EGFR ITGB1 ITGB3

1.96e-04121344M39823
PathwayBIOCARTA_EPHA4_PATHWAY

ITGB1 EPHA4

2.01e-049342MM1388
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

LAMC1 SPRY2 ADAM17 IGF1R EGFR ITGB1 ITGB3

2.32e-04532347M27870
PathwayPID_PTP1B_PATHWAY

SPRY2 EGFR ITGB3

2.61e-0452343M50
PathwayREACTOME_SIGNALING_BY_EGFR

SPRY2 ADAM17 EGFR

2.77e-0453343M27039
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS

ZNF355P ZNF490 ZNF726

3.26e-0456343MM17236
PathwayBIOCARTA_UCALPAIN_PATHWAY

ITGB1 ITGB3

3.67e-0412342MM1525
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMC1 ITGB1 ITGB3

3.80e-0459343M27218
PathwayWP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM

BMPER FST ITGB1

3.99e-0460343M40048
PathwayBIOCARTA_UCALPAIN_PATHWAY

ITGB1 ITGB3

5.05e-0414342M13143
PathwayREACTOME_SYNDECAN_INTERACTIONS

ITGB1 ITGB3

5.05e-0414342MM14923
PathwayWP_PLEURAL_MESOTHELIOMA

LAMC1 TRAF2 IGF1R EGFR ITGB1 ITGB3

5.65e-04439346M42563
PathwayREACTOME_L1CAM_INTERACTIONS

EGFR ITGB1 ITGB3

5.77e-0468343MM14968
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

LTBP3 FST ITGB1 ITGB3

5.82e-04161344M27871
PathwayREACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING

ZDHHC7 IGF1R EGFR

6.55e-0471343MM15590
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LAMC1 ADAM17 LTBP3 ITGB1 ITGB3

7.08e-04300345M610
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

LAMC1 IGF1R EGFR ITGB1 ITGB3

7.29e-04302345M39719
PathwayBIOCARTA_TEL_PATHWAY

IGF1R EGFR

7.51e-0417342MM1508
PathwayBIOCARTA_TEL_PATHWAY

IGF1R EGFR

7.51e-0417342M10401
PathwayREACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING

ZDHHC7 IGF1R EGFR

7.69e-0475343M27874
PathwayREACTOME_ECM_PROTEOGLYCANS

LAMC1 ITGB1 ITGB3

7.99e-0476343M27219
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

LTBP3 ITGB1 ITGB3

8.30e-0477343MM14670
PathwayBIOCARTA_PTEN_PATHWAY

EGFR ITGB1

8.43e-0418342M10145
PathwayBIOCARTA_MCALPAIN_PATHWAY

EGFR ITGB1

9.41e-0419342MM1434
PathwayBIOCARTA_MCALPAIN_PATHWAY

EGFR ITGB1

9.41e-0419342M8719
PathwayKEGG_PATHWAYS_IN_CANCER

LAMC1 TRAF2 IGF1R EGFR ITGB1

1.01e-03325345M12868
PathwayWP_FOCAL_ADHESION

LAMC1 EGFR ITGB1 ITGB3

1.02e-03187344MM15913
PathwayWP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY

LAMC1 IGF1R EGFR ITGB1 ITGB3

1.03e-03326345MM15917
PathwayWP_GLIOBLASTOMA_SIGNALING

SPRY2 IGF1R EGFR

1.03e-0383343M39637
PathwayKEGG_SMALL_CELL_LUNG_CANCER

LAMC1 TRAF2 ITGB1

1.07e-0384343M3228
PathwayKEGG_ECM_RECEPTOR_INTERACTION

LAMC1 ITGB1 ITGB3

1.07e-0384343M7098
PathwayWP_HAIR_FOLLICLE_DEVELOPMENT_CYTODIFFERENTIATION_STAGE_3_OF_3

ADAM17 EGFR FST

1.18e-0387343M39465
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF729 ZNF490 ZNF778 ZNF799 ZNF493 EGFR ZNF43 ZNF268 ZNF726 ZNF77

1.19e-0313873410M734
PathwayWP_PI3KAKT_SIGNALING

LAMC1 IGF1R EGFR ITGB1 ITGB3

1.22e-03339345M39736
PathwayKEGG_PROSTATE_CANCER

IGF1R EGFR INSRR

1.26e-0389343M13191
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_ATTACHMENT_AND_ENTRY

IGF1R EGFR

1.38e-0323342M48234
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY

ITGB1 ITGB3

1.38e-0323342M47537
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY

ITGB1 ITGB3

1.38e-0323342M47720
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

LTBP3 ITGB1 ITGB3

1.48e-0394343M1041
PathwayBIOCARTA_TFF_PATHWAY

EGFR ITGB1

1.51e-0324342M15926
PathwayWP_SMALL_CELL_LUNG_CANCER

LAMC1 TRAF2 ITGB1

1.57e-0396343M39834
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

IGF1R EGFR

1.64e-0325342M47934
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

EGFR ITGB1 ITGB3 INSRR

1.65e-03213344M18306
PathwayPID_INTEGRIN_CS_PATHWAY

ITGB1 ITGB3

1.77e-0326342M47
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY

ITGB1 ITGB3

1.77e-0326342M47719
PathwayREACTOME_SYNDECAN_INTERACTIONS

ITGB1 ITGB3

1.91e-0327342M27217
PathwayWP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING

EGFR ITGB1

2.05e-0328342M39572
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY

ITGB1 ITGB3

2.05e-0328342M47655
PathwayBIOCARTA_TFF_PATHWAY

EGFR ITGB1

2.20e-0329342MM1522
PathwayREACTOME_MET_ACTIVATES_PTK2_SIGNALING

LAMC1 ITGB1

2.35e-0330342M27772
PathwayREACTOME_LAMININ_INTERACTIONS

LAMC1 ITGB1

2.35e-0330342M27216
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

ITGB1 ITGB3

2.35e-0330342M47724
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY

ITGB1 ITGB3

2.35e-0330342M47718
PathwayBIOCARTA_AGR_PATHWAY

EGFR ITGB1

2.51e-0331342MM1343
PathwayREACTOME_EGFR_DOWNREGULATION

SPRY2 EGFR

2.51e-0331342MM14705
PathwayREACTOME_EGFR_DOWNREGULATION

SPRY2 EGFR

2.51e-0331342M16597
PathwayWP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING

IGF1R ITGB1

2.51e-0331342MM15818
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

ITGB1 ITGB3

2.68e-0332342MM14924
PathwayBIOCARTA_AGR_PATHWAY

EGFR ITGB1

2.84e-0333342M6220
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

SPRY2 IGF1R EGFR ITGB1 ITGB3

3.06e-03418345MM15587
PathwayPID_ARF6_PATHWAY

EGFR ITGB3

3.20e-0335342M86
PathwayWP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING

IGF1R ITGB1

3.38e-0336342M39569
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EGFR ITGB1 ITGB3 EPHA4

3.44e-03261344MM15676
PathwayREACTOME_ESR_MEDIATED_SIGNALING

ZDHHC7 IGF1R EGFR

3.97e-03133343MM15529
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

ZNF355P ZNF490 ZNF726

4.22e-03136343MM14848
PathwayPID_ERBB1_INTERNALIZATION_PATHWAY

SPRY2 EGFR

4.37e-0341342M214
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

LAMC1 ITGB1

4.37e-0341342M27778
PathwayPID_ECADHERIN_STABILIZATION_PATHWAY

IGF1R EGFR

4.37e-0341342M232
PathwayPID_TCPTP_PATHWAY

EGFR ITGB1

4.58e-0342342M91
PathwayPID_INTEGRIN3_PATHWAY

LAMC1 ITGB3

4.79e-0343342M53
PathwayBIOCARTA_KERATINOCYTE_PATHWAY

TRAF2 EGFR

5.47e-0346342M19118
PathwayPID_TNF_PATHWAY

TRAF2 ADAM17

5.47e-0346342M128
PathwayBIOCARTA_KERATINOCYTE_PATHWAY

TRAF2 EGFR

5.47e-0346342MM1428
PathwayREACTOME_ECM_PROTEOGLYCANS

ITGB1 ITGB3

5.70e-0347342MM14925
PathwayWP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS

ITGB1 ITGB3

5.70e-0347342M39829
PathwayPID_AJDISS_2PATHWAY

IGF1R EGFR

5.94e-0348342M142
PathwayREACTOME_SIGNALING_BY_EGFR

SPRY2 EGFR

6.19e-0349342MM14695
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF729 ZNF355P ZNF493 ZNF43 ZNF726

1.20e-111548515885501
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF729 ZNF355P ZNF778 ZNF493 ZNF43 ZNF726

6.68e-11494869630514
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF490 ZNF778 ZNF799 ZNF229 ZNF493 ZNF726 ZNF728 ZNF77

1.46e-1018148837372979
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF729 ZNF355P ZNF493 ZNF43 ZNF726

4.68e-102948514563677
Pubmed

Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrins.

EGFR ITGB1 ITGB3

2.47e-09348318375753
Pubmed

Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.

IGF1R EGFR ITGB1

9.86e-09448333477820
Pubmed

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.

SPRY2 EGFR ARIH2

8.60e-08748312234920
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

IGF1R EGFR EPHA4 INSRR

2.81e-074048430898150
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

IGF1R EGFR ITGB1 ITGB3 INSRR

2.90e-0710148523382219
Pubmed

Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.

SPRY2 EGFR SPRY4

2.94e-071048318273061
Pubmed

Functional analysis of the SRY-KRAB interaction in mouse sex determination.

ZNF729 ZNF493 ZNF43

2.94e-071048318588511
Pubmed

Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.

ZNF729 ZNF493 ZNF43

4.04e-071148315469996
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF729 ZNF493 ZNF43

6.99e-071348319850934
Pubmed

An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.

SPRY2 FST SPRY4

6.99e-071348318077585
Pubmed

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

CCN6 TRAF2 LTBP3 IGF1R CHRDL2 EGFR FST

9.28e-0738348719453261
Pubmed

Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.

IGF1R ITGB1

1.87e-06248215289498
Pubmed

Implication of epithelial-mesenchymal transition in IGF1R-induced resistance to EGFR-TKIs in advanced non-small cell lung cancer.

IGF1R EGFR

1.87e-06248226554308
Pubmed

Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival.

ADAM17 EGFR

1.87e-06248215337756
Pubmed

A disintegrin and metalloproteinase 17 (ADAM17) mediates epidermal growth factor receptor transactivation by angiotensin II on hepatic stellate cells.

ADAM17 EGFR

1.87e-06248224412389
Pubmed

β3 integrin is dispensable for conditioned fear and hebbian forms of plasticity in the hippocampus.

ITGB1 ITGB3

1.87e-06248222748100
Pubmed

Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells.

IGF1R EGFR

1.87e-06248217320820
Pubmed

Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas.

IGF1R INSRR

1.87e-06248214654552
Pubmed

Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17.

ADAM17 IGF1R

1.87e-06248222506015
Pubmed

Co-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma.

IGF1R EGFR

1.87e-06248227105537
Pubmed

Molecular interactions of ErbB1 (EGFR) and integrin-β1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance.

EGFR ITGB1

1.87e-06248223595626
Pubmed

Protective effect of hyaluronic acid on interleukin-1-induced deregulation of beta1-integrin and insulin-like growth factor-I receptor signaling and collagen biosynthesis in cultured human chondrocytes.

IGF1R ITGB1

1.87e-06248217899316
Pubmed

The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation.

IGF1R EGFR

1.87e-06248227213344
Pubmed

β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells.

EGFR ITGB1

1.87e-06248221478906
Pubmed

Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.

SPRY2 SPRY4

1.87e-06248226540287
Pubmed

Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice.

SPRY2 SPRY4

1.87e-06248219101957
Pubmed

Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.

ITGB1 ITGB3

1.87e-06248222511753
Pubmed

IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations.

IGF1R EGFR

1.87e-06248223994953
Pubmed

The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation.

ITGB1 ITGB3

1.87e-06248212690105
Pubmed

Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer.

ITGB1 ITGB3

1.87e-06248231618629
Pubmed

Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells.

IGF1R EGFR

1.87e-06248225341922
Pubmed

Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations.

ADAM17 EGFR

1.87e-06248227089454
Pubmed

A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer.

IGF1R EGFR

1.87e-06248228498434
Pubmed

Expression of insulin-like growth factor 1 receptor (IGF-1R) predicts poor responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer patients harboring activating EGFR mutations.

IGF1R EGFR

1.87e-06248225617986
Pubmed

Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.

IGF1R EGFR

1.87e-06248217525128
Pubmed

Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas.

IGF1R EGFR

1.87e-06248222700994
Pubmed

β1A integrin is a master regulator of invadosome organization and function.

ITGB1 ITGB3

1.87e-06248220926684
Pubmed

The insulin-like growth factor 1 receptor causes acquired resistance to erlotinib in lung cancer cells with the wild-type epidermal growth factor receptor.

IGF1R EGFR

1.87e-06248224458568
Pubmed

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.

ADAM17 EGFR

1.87e-06248221407195
Pubmed

The metalloproteinase ADAM17 and the epidermal growth factor receptor (EGFR) signaling drive the inflammatory epithelial response in Sjögren's syndrome.

ADAM17 EGFR

1.87e-06248224664458
Pubmed

Both epidermal growth factor and insulin-like growth factor receptors are dispensable for structural intestinal adaptation.

IGF1R EGFR

1.87e-06248225818318
Pubmed

Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites.

EGFR ITGB1

1.87e-06248214512423
Pubmed

Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection.

ITGB1 ITGB3

1.87e-06248222422622
Pubmed

Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients.

IGF1R EGFR

1.87e-06248223314677
Pubmed

Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells.

SPRY2 EGFR

1.87e-06248220624167
Pubmed

Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons.

SPRY2 SPRY4

1.87e-06248221240919
Pubmed

A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury.

ADAM17 EGFR

1.87e-06248225738567
Pubmed

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17.

ADAM17 EGFR

1.87e-06248226338334
Pubmed

The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.

ITGB1 ITGB3

1.87e-06248218165225
Pubmed

TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination.

ADAM17 EGFR

1.87e-06248225186737
Pubmed

Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer.

SPRY2 SPRY4

1.87e-06248225630587
Pubmed

Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells.

SPRY2 SPRY4

1.87e-06248223831057
Pubmed

Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains.

EGFR ITGB3

1.87e-06248228487468
Pubmed

Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.

SPRY2 SPRY4

1.87e-06248217156747
Pubmed

Integrin subunit β1 and laminin γ1 chain expression: a potential prognostic biomarker in cervical cancer.

LAMC1 ITGB1

1.87e-06248232845182
Pubmed

NELL-1 promotes cell adhesion and differentiation via Integrinβ1.

NELL1 ITGB1

1.87e-06248222807400
Pubmed

Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor.

IGF1R EGFR

1.87e-06248218829558
Pubmed

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.

ADAM17 EGFR

1.87e-06248222565824
Pubmed

A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).

ADAM17 EGFR

1.87e-06248222833676
Pubmed

Relationships of insulin-like growth factor-1 receptor and epidermal growth factor receptor expression to clinical outcomes in patients with colorectal cancer.

IGF1R EGFR

1.87e-06248219033715
Pubmed

siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury.

SPRY2 SPRY4

1.87e-06248226655476
Pubmed

Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib.

IGF1R EGFR

1.87e-06248217047074
Pubmed

Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells.

IGF1R EGFR

1.87e-06248218949375
Pubmed

Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.

IGF1R EGFR

1.87e-06248217918158
Pubmed

Integrin expression regulates neuroblastoma attachment and migration.

IGF1R ITGB1

1.87e-06248215256055
Pubmed

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways.

ADAM17 EGFR

1.87e-06248225948294
Pubmed

Extracellular oxidation in cystic fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity.

ADAM17 EGFR

1.87e-06248229351448
Pubmed

Bacterial Outer Membrane Protein OmpX Regulates β1 Integrin and Epidermal Growth Factor Receptor (EGFR) Involved in Invasion of M-HeLa Cells by Serratia proteamaculans.

EGFR ITGB1

1.87e-06248234948042
Pubmed

Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor.

IGF1R EGFR

1.87e-06248216037379
Pubmed

High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients.

IGF1R EGFR

1.87e-06248219153117
Pubmed

Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β.

ITGB1 ITGB3

1.87e-06248224006485
Pubmed

Cooperation Between Platelet β1 and β3 Integrins in the Arrest of Bleeding Under Inflammatory Conditions in Mice-Brief Report.

ITGB1 ITGB3

1.87e-06248239145395
Pubmed

Activation of beta 1 but not beta 3 integrin increases cell traction forces.

ITGB1 ITGB3

1.87e-06248223395612
Pubmed

Spironolactone inhibits podocyte motility via decreasing integrin β1 and increasing integrin β3 in podocytes under high-glucose conditions.

ITGB1 ITGB3

1.87e-06248226352002
Pubmed

A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity.

IGF1R EGFR

1.87e-06248221393993
Pubmed

ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells.

SPRY2 EGFR

1.87e-06248220956544
Pubmed

Integrins β1 and β3 are biomarkers of uterine condition for embryo transfer.

ITGB1 ITGB3

1.87e-06248227782833
Pubmed

Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.

SPRY2 SPRY4

1.87e-06248219424491
Pubmed

Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation.

IGF1R EGFR

1.87e-06248231758670
Pubmed

A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells.

ADAM17 ITGB1

1.87e-06248222413019
Pubmed

Expression and clinical significance of epidermal growth factor receptor and insulin-like growth factor receptor 1 in patients with ampullary adenocarcinoma.

IGF1R EGFR

1.87e-06248226165226
Pubmed

Computational model of EGFR and IGF1R pathways in lung cancer: a Systems Biology approach for Translational Oncology.

IGF1R EGFR

1.87e-06248221620944
Pubmed

ADAM17 transactivates EGFR signaling during embryonic eyelid closure.

ADAM17 EGFR

1.87e-06248223211830
Pubmed

SNPs in microRNA-binding sites in the ITGB1 and ITGB3 3'-UTR increase colorectal cancer risk.

ITGB1 ITGB3

1.87e-06248224777809
Pubmed

Lentivirus-mediated disintegrin and metalloproteinase 17 RNA interference reversed the acquired resistance to gefitinib in lung adenocarcinoma cells in vitro.

ADAM17 EGFR

1.87e-06248228960861
Pubmed

Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor.

IGF1R EGFR

1.87e-06248215253384
Pubmed

BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor.

SPRY2 FST SPRY4

2.35e-061948322629441
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZNF355P ZNF778 ZNF726

2.77e-06204837479878
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZNF355P ZNF778 ZNF726

2.77e-06204832542606
Pubmed

FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.

SPRY2 EGFR SPRY4

4.89e-062448321655085
Pubmed

The protein tyrosine kinase family of the human genome.

IGF1R EGFR EPHA4 INSRR

5.42e-068348411114734
Pubmed

Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.

IGF1R EGFR EPHA4

5.55e-062548315254900
Pubmed

ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.

LAMC1 ADAM17 ITGB1

5.55e-062548317170699
Pubmed

Epidermal growth factor receptor (EGFR), HER2 and insulin-like growth factor-1 receptor (IGF-1R) status in ovarian adult granulosa cell tumours.

IGF1R EGFR

5.59e-06348224206174
Pubmed

Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.

ITGB3 SPRY4

5.59e-06348223955631
Pubmed

CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17.

ADAM17 ITGB1

5.59e-06348230455686
InteractionTRIM28 interactions

ZNF823 ZNF490 ZNF778 ZNF799 TES ZNF229 ZNF493 ZC3H7B UHRF2 EGFR ZNF268 ZNF726 ZNF728 ARIH2 ZNF77

9.30e-0714744815int:TRIM28
InteractionHOXA1 interactions

VWC2L NELL1 SPRY2 TRAF2 LTBP3 CHRDL2 FST SPRY4

1.79e-06356488int:HOXA1
InteractionPIK3R2 interactions

LTBP3 IGF1R EGFR RNF144A EPHA4 INSRR

1.70e-05230486int:PIK3R2
InteractionGCN1 interactions

LAMC1 TES IGF1R EGFR ITGB1 ITGB3 RNF144A

1.76e-05349487int:GCN1
InteractionSORL1 interactions

CCN6 EGFR FST FEZF1 EPHA4

1.89e-05138485int:SORL1
InteractionSPRY2 interactions

SPRY2 TRAF2 TES EGFR SPRY4

3.01e-05152485int:SPRY2
InteractionDNAJC10 interactions

LAMC1 LTBP3 IGF1R EGFR ARIH2 INSRR

3.39e-05260486int:DNAJC10
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF729 ZNF493 ZNF43 ZNF726 ZNF728

1.91e-07122485chr19p12
Cytoband19p12

ZNF729 ZNF493 ZNF726 ZNF728

2.52e-069048419p12
Cytoband19p13.2

ZNF823 ZNF490 ZNF799

1.80e-0322948319p13.2
Cytoband20q13.12

WFDC3 PI3

1.82e-036048220q13.12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 ZNF823 ZNF490 ZNF778 ZNF799 ZNF80 ZNF229 ZNF493 FEZF1 ZNF43 ZNF268 ZNF726 ZNF728 ZNF77

3.61e-11718361428
GeneFamilyCD molecules|Integrin beta subunits

ITGB1 ITGB3

1.38e-0493621159
GeneFamilyWAP four-disulfide core domain containing|Fibronectin type III domain containing

WFDC3 PI3

5.78e-0418362361
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM29 ADAM17

1.31e-032736247
GeneFamilyReceptor Tyrosine Kinases|CD molecules

IGF1R INSRR

2.87e-0340362321
GeneFamilyFibronectin type III domain containing

IGF1R EPHA4 INSRR

3.92e-03160363555
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM17 IGF1R ITGB1 ITGB3

7.54e-03394364471
GeneFamilyPHD finger proteins

UHRF2 NSD3

1.38e-029036288
GeneFamilyRing finger proteins

TRAF2 UHRF2 RNF144A

1.72e-0227536358
CoexpressionNABA_MATRISOME

VWC2L CCN6 NELL1 LAMC1 ADAM29 PI3 ADAM17 LTBP3 BMPER CHRDL2 FST

1.87e-0610264811M5889
CoexpressionBECKER_TAMOXIFEN_RESISTANCE_DN

TSPAN6 ADAM17 IGF1R ZNF43

2.93e-0654484M15676
CoexpressionNABA_MATRISOME

VWC2L CCN6 NELL1 LAMC1 ADAM29 ADAM17 LTBP3 BMPER CHRDL2 FST

1.17e-0510084810MM17056
CoexpressionGSE27859_MACROPHAGE_VS_CD11C_INT_F480_INT_DC_UP

TRAF2 TES IGF1R ITGB1 RNF144A

1.52e-05171485M8594
CoexpressionNABA_ECM_GLYCOPROTEINS

CCN6 NELL1 LAMC1 LTBP3 BMPER

2.59e-05191485MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

CCN6 NELL1 LAMC1 LTBP3 BMPER

2.93e-05196485M3008
CoexpressionGSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN

SPRY2 IGF1R UHRF2 ZNF268 ARIH2

2.93e-05196485M7672
CoexpressionGSE13411_NAIVE_VS_SWITCHED_MEMORY_BCELL_DN

ZDHHC7 ZNF493 ITGB1 ZNF268 RNF144A

3.08e-05198485M3242
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

ZNF729 ZNF355P ZNF778 MT3 ZNF493 ZNF43 ZNF726

3.18e-05497487MM863
CoexpressionERWIN_COHEN_BLOOD_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_7DY_DN

PI3 IGF1R

6.86e-057482M41029
CoexpressionGAL_LEUKEMIC_STEM_CELL_UP

IGF1R ZC3H7B ITGB3 ARIH2

9.49e-05130484M17428
CoexpressionMIKKELSEN_ES_ICP_WITH_H3K4ME3

ZNF729 ZNF823 ZNF778 ZNF799 MT3 ZNF493 ZNF43 ZNF726

9.89e-05807488MM855
CoexpressionNABA_CORE_MATRISOME

CCN6 NELL1 LAMC1 LTBP3 BMPER

1.33e-04270485MM17057
CoexpressionNABA_CORE_MATRISOME

CCN6 NELL1 LAMC1 LTBP3 BMPER

1.45e-04275485M5884
CoexpressionFAN_OVARY_CL11_MURAL_GRANULOSA_CELL

TSPAN6 LAMC1 TES IGF1R FST ITGB1

1.54e-04444486M41713
CoexpressionCHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN

LAMC1 SPRY2 PI3 EGFR FST ITGB1

1.79e-04457486M14507
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

ZNF823 TSPAN6 ZNF799 ZNF43 ZNF726

5.88e-071504851aa9320d97ff10994ea024751790524fe133aba9
ToppCellCV-Mild-4|CV / Virus stimulation, Condition and Cluster

TES MT3 PAICS INSRR

2.65e-05160484be89efeeecb0de96ce136a7a62738f15dc0badb2
ToppCellfacs-Heart-LV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 LTBP3 BMPER EGFR

3.29e-05169484849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 LTBP3 BMPER EGFR

3.85e-05176484f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCellwk_08-11-Mesenchymal-Chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CCN6 BMPER CHRDL2 FST

3.85e-051764841af28b701c4598ce761f85adbd5d79e4918d265a
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 LTBP3 BMPER EGFR

3.85e-05176484fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMPER EGFR FST SPRY4

4.11e-05179484a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWC2L NELL1 BMPER EPHA4

4.29e-051814846e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF490 EGFR PAICS

4.97e-056648357fd31a25addc48793d7975eadccf4c5a41a8b03
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC1 BMPER FST SPRY4

4.98e-05188484997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellfacs-BAT-Fat-18m-Mesenchymal|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.08e-05189484bba28f57a0708515fdd5acd9592dbbe4a4f57116
ToppCellfacs-BAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.08e-05189484cf293b23a4c0e8a0c9f09115b1d53d9b11de72e2
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN6 LAMC1 FST INSRR

5.08e-051894846b3b42d758b63a0df62310c34fa3bde421c1afd7
ToppCellfacs-BAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.08e-0518948487323e86a5b5d159920a07e6bd7ef5e3438cd085
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN6 LAMC1 FST INSRR

5.08e-05189484344b23d3c47d0665dda1cd4856a5e72f1c28cfb3
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.29e-051914846cab0334f76c973880bd8d1638856f2f6e4a249a
ToppCelldroplet-Fat-Gat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.29e-05191484850c6fff6dc795431ef534fdaa41e4ad50f7367a
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.29e-051914848b2b00202d3c98bccbae1b4a23713892fad0ff23
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TES CHRDL2 FST ITGB1

5.40e-05192484d0fb6885f023d55a2b7984c99db9c6463258f788
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.40e-05192484beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.51e-05193484316ebdf15f75d88c348f909b643fcd315364ca84
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.51e-051934841afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP3 BMPER EGFR

5.51e-0519348449600db68ed65cafc67bd45a285b364e4f5f88af
ToppCelldroplet-Fat-Scat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 BMPER EGFR FST

5.51e-051934848dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP3 BMPER EGFR

5.51e-0519348445b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SPRY2 MT3 EGFR SPRY4

5.62e-051944848b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCellfacs-Heart-RA-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 SPRY2 LTBP3 EGFR

5.62e-05194484bc945450b350f597c3ff910d3a14a533d90086a8
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP3 BMPER EGFR

5.73e-0519548469a29d03e664b72f32d41876510c62345c3aed31
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP3 BMPER EGFR

5.73e-051954841cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 LTBP3 BMPER EGFR

5.73e-051954849cef6f18664518060af7c192310dddce6d70345a
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 SPRY2 EGFR FST

5.85e-0519648465f2f51e17f1869f3468813127b96d3048d8ad41
ToppCellfacs-SCAT-Fat-18m-Mesenchymal|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 SPRY2 EGFR FST

5.85e-051964842cd83176f2e8a9e6fa3c08cb33928a61e5fc43b6
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 SPRY2 EGFR FST

5.85e-05196484e4ed897900a6472738bc6be2fb4817192727225d
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL1 LAMC1 ITGB1 SPRY4

5.97e-05197484ea746772adb9df4ddb0508d4ef35f2027bf09c35
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMC1 BMPER EGFR FST

5.97e-0519748417344464fdcc5ba0c03959696b97c195f11e644c
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LAMC1 EGFR ITGB1 SPRY4

5.97e-05197484c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMC1 BMPER EGFR FST

5.97e-051974843bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TES BMPER CHRDL2 FST

5.97e-051974845a63c2b824c7d0dbbc706e408459c9b9fe65daaa
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMC1 BMPER EGFR FST

5.97e-051974845b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NELL1 MT3 EGFR

3.79e-041314835a7bd9d0435e61905e6bd42518953b5aead03e88
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tfh|GI_small-bowel / Manually curated celltypes from each tissue

ZNF80 EPHA4 ZNF77

4.05e-04134483bf94ce5edde8912a27010e229c313d8102d6de62
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Whrn_Tox2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VWC2L BMPER EPHA4

4.90e-0414348336ce6f163fb33141c86288086c354b91853fad25
ToppCellfacs-Trachea-nan-18m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN6 NELL1 MT3

5.74e-041514835aa98ca9abe37edbc750fd970852a1cc903a5881
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NELL1 MT3 EGFR

5.85e-04152483f748ee34167f79ecda116aa1914afab47403385a
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

VWC2L ADAM29 FST

6.08e-04154483df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PI3 ITGB3 EPHA4

6.31e-04156483fc8b8aef29d6d1c0f0c1d08280d8aaff8d30535e
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

ITGB1 ZNF728 EPHA4

6.31e-04156483e308328f560c5ee7e9f95ac5db162f2d821ca39c
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF490 BMPER EPHA4

6.43e-04157483f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF490 BMPER EPHA4

6.43e-0415748343a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NELL1 MT3 EGFR

6.54e-04158483c736834269c89e003c61a62b63e4e50dbf0e1538
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VWC2L BMPER EGFR

6.91e-041614833b5d7a3dab479c6959a428f3954dedd989900276
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NELL1 MT3 EGFR

7.55e-0416648337f5264491d75af690dd94eea2cf7763f42b2a2a
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EGFR FST INSRR

7.68e-04167483fe3338f99f94c0dac37e3d649dfdce82e4a56022
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-NK_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 LTBP3 ITGB1

7.68e-04167483aef22535a76e93472bcedacbb2c6991f3c9c8cd5
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TES CHRDL2 FST

7.82e-0416848374d6dbf9295933acdee785af9b73a94377d15412
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VWC2L BMPER EGFR

7.82e-04168483f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPAN6 NELL1 MT3

7.95e-04169483d382a76d85875663502cc7dde2e3e0682605768e
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Plasma_cells|B_lymphocytes / Location, Cell class and cell subclass

TSPAN6 TMEM92 FST

7.95e-04169483150c08c7b1dc0f46173a7b8f6a3fc70d82906c0d
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

BMPER ITGB3 EPHA4

8.09e-0417048367415b098e8ba815b501e557192a9f2b10ee995a
ToppCellBasal_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

TSPAN6 BMPER FST

8.09e-04170483776d4224a682b6c648041827efd69794f88906f0
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

ADAM17 TMEM92 EPHA4

8.23e-04171483adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TES CHRDL2 FST

8.23e-04171483fe0665c5ca01b0b2cc8f20d64587f0847c3d215c
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN6 SPRY2 MT3

8.37e-04172483b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN6 SPRY2 MT3

8.37e-041724832f1673fcb2356684d60871debb0f159aec553a1c
ToppCellNS-critical-d_0-4-Epithelial-FOXN4+|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MT3 TMEM92 FEZF1

8.37e-04172483a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 IGF1R ITGB3

8.51e-0417348353e97835d7a518c278e7b90a0734eb0095d6aa33
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPRY2 IGF1R ITGB3

8.51e-04173483117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 IGF1R ITGB3

8.51e-041734833612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 MT3 ZNF726

8.51e-041734837a3115e7cf7e2f345192cde0656a7f0193594a5f
ToppCelldroplet-Lung-LUNG-1m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 IGF1R ITGB3

8.51e-04173483889a880de5fc19d26b82cfef3067869a28ef17ca
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 IGF1R ITGB3

8.51e-041734834dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPRY2 IGF1R ITGB3

8.51e-0417348301df9baeedf30e3a4891738554cdd300394dbb96
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 CHRDL2 FST

8.65e-0417448368a6ed81e7e1f95b61f7ee20403980fa3a8db4d0
ToppCellCV-Healthy-4|Healthy / Virus stimulation, Condition and Cluster

MT3 PAICS INSRR

8.65e-0417448326544cc5f51cb4dc1251e62d9f80b6c956194d38
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|356C / Donor, Lineage, Cell class and subclass (all cells)

TSPAN6 PI3 MT3

8.80e-041754834bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TSPAN6 NELL1 ITGB1

8.80e-041754832e54961846c65b185d9bd6e305dd81205579d890
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|356C / Donor, Lineage, Cell class and subclass (all cells)

TSPAN6 PI3 MT3

8.80e-04175483af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPAN6 NELL1 MT3

8.80e-04175483f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCellwk_15-18-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

BMPER CHRDL2 FST

8.80e-04175483a84965d28438a4228d841b357c2cd75cf4b59a63
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TSPAN6 NELL1 ITGB1

8.80e-04175483efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPAN6 NELL1 MT3

8.80e-041754837bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCellcellseq2-Mesenchymal-Myocytic-Myocytic_1-Pericyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPRY2 BMPER SPRY4

9.09e-0417748368263456a3c93cd195b321b309ff59e156d732fe
ToppCellcellseq2-Mesenchymal-Myocytic-Myocytic_1|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPRY2 BMPER SPRY4

9.09e-04177483e415e448c37adc102d766235e9953dec32c021f1
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPAN6 NELL1 MT3

9.24e-041784833d120458a0a56097532ebfa5fc6f77b52af2af2a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWC2L NELL1 EGFR

9.39e-04179483cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

LAMC1 EGFR INSRR

9.39e-04179483dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellCV-Severe-4|Severe / Virus stimulation, Condition and Cluster

SPRY2 MT3 PAICS

9.54e-04180483cf84a01e6a33e5d27ad7be1d9069a0370b5116d1
ToppCellNeuroendocrine-neuroendo-1|World / Class top

NELL1 MT3 FEZF1

9.54e-0418048350fdd182a083380899b5943cb5f55ffd77e2a7d4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWC2L NELL1 EGFR

9.54e-04180483c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN6 SPRY2 SPRY4

9.70e-041814831037051eb82313c13346617b33f3c4c648181c4d
ToppCellwk_15-18-Mesenchymal-Chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

BMPER CHRDL2 FST

9.70e-041814838950844b3e65c7028d80da5787ae2ce509c3d52d
ToppCellwk_08-11-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ZNF799 BMPER CHRDL2

9.85e-0418248300a148b1e499bf16325491536d187d4dd6b70c06
ToppCellCV-Severe-4|CV / Virus stimulation, Condition and Cluster

SPRY2 MT3 PAICS

9.85e-04182483c19bbc43d97c426aec37414f46f667a19b62a257
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWC2L BMPER EPHA4

1.00e-03183483b5d041d0a3506c33de72bf14fa0443f4410fddf1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWC2L NELL1 EPHA4

1.00e-03183483274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRAF2 BMPER ITGB3

1.00e-031834835377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TES PAICS EPHA4

1.02e-03184483e93633d89a9c54c8d2819f56372815b4ca149f06
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LTBP3 FST INSRR

1.03e-031854831b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMC1 FST ITGB3

1.03e-03185483d5f5866924648a3c14e2596218fd548a31777aa3
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 ZC3H7B RNF144A

1.03e-03185483bdd2e6cb20294b39a9d856004bf57ba69cf877e2
Drugmethyl ethyl ketone

SPRY2 TRAF2 PI3 LTBP3 IGF1R EGFR ITGB1 ITGB3 SPRY4 EPHA4

2.64e-075874710CID000006569
DrugtAPE

PI3 TES MT3

7.81e-0619473CID000069007
DrugAC1NRBJE

PI3 ADAM17 IGF1R EGFR ITGB1

1.52e-05152475CID005288446
Drugsorafenib

NELL1 ADAM17 IGF1R EGFR EPHA4

1.83e-05158475CID000216239
Drugimatinib

NELL1 PI3 IGF1R EGFR NSD3 EPHA4 INSRR

2.67e-05430477CID000005291
Drug3-quinolinecarbonitrile

IGF1R EGFR

4.15e-055472CID000093177
Drug2-(2,6-dioxopiperidin-3-yl)phthalimidine

ITGB1 ITGB3

4.15e-055472ctd:C001079
DrugHydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; PC3; HT_HG-U133A

ADAM17 ZC3H7B EGFR NSD3 ARIH2

5.01e-051954757309_UP
DrugSpectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A

SPRY2 ZNF493 ZC3H7B FST ITGB3

5.01e-051954753327_UP
DrugNalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; HL60; HG-U133A

TES IGF1R RNF144A NSD3 ARIH2

5.14e-051964751379_UP
DrugMetanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; HL60; HG-U133A

LAMC1 TES ITGB3 ZNF268 NSD3

5.14e-051964752015_UP
DrugGraveoline [485-61-0]; Down 200; 14.4uM; HL60; HT_HG-U133A

TRAF2 ZNF493 ZC3H7B ARIH2 EPHA4

5.14e-051964752179_DN
DiseaseNeonatal inflammatory skin and bowel disease

ADAM17 EGFR

2.48e-062472C4751120
Diseasehigh grade glioma (implicated_via_orthology)

IGF1R EGFR INSRR

4.79e-0544473DOID:3070 (implicated_via_orthology)
Diseasealcohol dependence (implicated_via_orthology)

IGF1R INSRR

8.88e-059472DOID:0050741 (implicated_via_orthology)
DiseaseColorectal Carcinoma

ZDHHC7 NELL1 LAMC1 ADAM29 UHRF2 EGFR ZNF43

1.15e-04702477C0009402
DiseaseHYPOGONADOTROPIC HYPOGONADISM 7 WITH OR WITHOUT ANOSMIA

FEZF1 SPRY4

1.35e-0411472146110
Diseasesleep disorder (implicated_via_orthology)

IGF1R INSRR

1.35e-0411472DOID:535 (implicated_via_orthology)
DiseaseHypogonadotropic hypogonadism 7 with or without anosmia

FEZF1 SPRY4

1.35e-0411472cv:C0342384
Diseasemedian neuropathy (biomarker_via_orthology)

MT3 EGFR

2.23e-0414472DOID:571 (biomarker_via_orthology)
Diseasediabetic neuropathy (implicated_via_orthology)

IGF1R INSRR

2.23e-0414472DOID:9743 (implicated_via_orthology)
DiseaseGraves' disease (is_marker_for)

IGF1R ITGB3

2.57e-0415472DOID:12361 (is_marker_for)
DiseaseAstrocytosis

ITGB1 ITGB3

3.33e-0417472C3887640
DiseaseGliosis

ITGB1 ITGB3

3.33e-0417472C0017639
DiseaseIdiopathic hypogonadotropic hypogonadism

FEZF1 SPRY4

3.74e-0418472C0342384
DiseaseAdrenocortical carcinoma

IGF1R EGFR

3.74e-0418472C0206686
Diseaseleft ventricular structural measurement

IGF1R ITGB3 EPHA4

3.78e-0488473EFO_0008205
Diseaseinflammatory bowel disease (is_implicated_in)

ADAM17 EGFR

4.17e-0419472DOID:0050589 (is_implicated_in)
Diseasetaurocholate measurement

NELL1 ZNF799

4.63e-0420472EFO_0010538
Diseaseglomerulonephritis (biomarker_via_orthology)

ITGB1 ITGB3

4.63e-0420472DOID:2921 (biomarker_via_orthology)
Diseasecorpus callosum volume measurement

NELL1 LAMC1 EGFR

5.50e-04100473EFO_0010299
DiseaseGlioblastoma Multiforme

TES EGFR INSRR

7.45e-04111473C1621958
Diseasediabetes mellitus (implicated_via_orthology)

IGF1R INSRR

7.88e-0426472DOID:9351 (implicated_via_orthology)
DiseaseKallmann Syndrome

FEZF1 SPRY4

7.88e-0426472C0162809
Diseaseglucose metabolism disease (implicated_via_orthology)

IGF1R INSRR

9.14e-0428472DOID:4194 (implicated_via_orthology)
DiseaseIgA glomerulonephritis (is_implicated_in)

SPRY2 IGF1R

1.05e-0330472DOID:2986 (is_implicated_in)
DiseaseSquamous cell carcinoma of lung

IGF1R EGFR

1.19e-0332472C0149782
DiseaseGrowth Disorders

LTBP3 IGF1R

1.51e-0336472C0018273
Diseasetesticular carcinoma

NELL1 SPRY4

1.86e-0340472EFO_0005088
Diseasediabetes mellitus (is_marker_for)

IGF1R EGFR

1.96e-0341472DOID:9351 (is_marker_for)
DiseaseCraniofacial Abnormalities

SPRY2 LTBP3 EGFR

1.98e-03156473C0376634
DiseaseNon-Small Cell Lung Carcinoma

MT3 EGFR ITGB1

1.98e-03156473C0007131
Diseaselung non-small cell carcinoma (is_marker_for)

EGFR ITGB1 ITGB3

2.49e-03169473DOID:3908 (is_marker_for)
DiseaseCardiomyopathy, Dilated

EGFR ITGB1

2.67e-0348472C0007193
DiseaseCardiomyopathy, Familial Idiopathic

EGFR ITGB1

2.90e-0350472C1449563
Diseasewaist-hip ratio

NELL1 ADAM17 LTBP3 IGF1R ITGB3 ZNF268 SPRY4

3.09e-031226477EFO_0004343
DiseaseNeoplasm Invasiveness

MT3 EGFR ITGB1

3.16e-03184473C0027626

Protein segments in the cluster

PeptideGeneStartEntry
CDCGPLKHCAKDPCC

ADAM29

411

Q9UKF5
LCCKDCKFLPSGKVC

ADAM29

441

Q9UKF5
DCPKCNICIEKNGGC

ARIH2

296

O95376
GICECGVCKCTDPKF

ITGB1

611

P05556
PKCEQKCESKCQPSC

LELP1

21

Q5T871
CKKCGAGDPSKCRPC

EPHA4

366

P54764
KGPCCACPKTEAEKQ

IGF1R

696

P08069
RCLKDTDCPGIKKCC

PI3

91

P19957
TDCPGIKKCCEGSCG

PI3

96

P19957
CKETCENVDCGPGKK

FST

91

P19883
ECEKCAKDCVCKGGE

MT3

41

P25713
VAGKCCKICPEDKAD

CHRDL2

306

Q6WN34
QCCKVCRPKCIYGGK

NELL1

326

Q92832
ATPFVLCCKCKCSKG

RNF144A

271

P50876
LCCKCKCSKGDDDPL

RNF144A

276

P50876
GCGCCKICAKQPGEI

CCN6

71

O95389
CKKCEGPCRKVCNGI

EGFR

326

P00533
KGCCPICTEKPGVCT

BMPER

351

Q8N8U9
GKCENKPGSFKCIAC

LTBP3

716

Q9NS15
FCHKCEGLCPKECKV

INSRR

316

P14616
KCPTCPDACTFKKEC

ITGB3

626

P05106
CSCKPGVMGDKCDRC

LAMC1

416

P11047
ACGKCKCKECASPRT

SPRY4

161

Q9C004
QGFGAPCLKCKEKCE

TES

16

Q9UGI8
DKKPFTCPTCGKGFC

FEZF1

396

A0PJY2
CGKCKCKECTYPRPL

SPRY2

181

O43597
GKCKDGKCIPFCERE

ADAM17

571

P78536
CEKIKKACGNFGIPC

PAICS

281

P22234
VCPKFPLTCDGCGKK

TRAF2

181

Q12933
CDLCGGDPEKKCHSC

UHRF2

331

Q96PU4
PGVKKCCTLGCNKSC

WFDC3

96

Q8IUB2
ILACPKGFKCCGDSC

TMEM92

31

Q6UXU6
PHKCKICGKGFDCPS

ZNF823

331

P16415
EKPCQCKHCGKAFTC

ZNF77

321

Q15935
EKPCECKECGKAFTG

ZNF778

306

Q96MU6
GEKPCKCTECGKAFC

ZNF268

916

Q14587
VKPCECKQCGKAFTC

ZNF490

471

Q9ULM2
GEKPCKCEECGKAFG

ZNF728

336

P0DKX0
PHKCKICGKGFDCPS

ZNF799

336

Q96GE5
KGFPKSCCKLEDCTP

TSPAN6

171

O43657
KCEKGGRLLCCESCP

NSD3

916

Q9BZ95
IDKPCGCNKCRKDCI

ZNF229

236

Q9UJW7
FCKCEKCGKAFNCPS

ZNF43

201

P17038
GEKPCKCEECGKAFS

ZNF726

281

A6NNF4
GEKPCKCVECGKVFN

ZNF80

101

P51504
KCTKVEHNGCCPECK

VWC2L

96

B2RUY7
GEKPCKCEECGKAFN

ZNF493

581

Q6ZR52
GEVIYKCPKCCCIKP

ZDHHC7

126

Q9NXF8
PCKCEECGKACKQSL

ZNF355P

211

Q9NSJ1
TGEKPCKCEECDKAF

ZNF729

1071

A6NN14
QKGKACPDGDKCRCA

ZC3H7B

896

Q9UGR2