Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	telomeric DNA binding	UPF2 WRN ZBTB10 XRCC6	1.36e-05	40	73	4	GO:0042162
GeneOntologyMolecularFunction	cyclin binding	PROCA1 XRCC6 FBXW7	2.82e-04	35	73	3	GO:0030332
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	EHMT2 PRDM16	3.64e-04	8	73	2	GO:0140948
GeneOntologyMolecularFunction	histone H3K9me2 methyltransferase activity	EHMT2 PRDM16	5.82e-04	10	73	2	GO:0140947
GeneOntologyBiologicalProcess	chromatin organization	HMGN5 NRDE2 PBRM1 ARID4B EHMT2 SUPT6H DPF3 NAP1L2 KDM2B SRPK2 DAXX LMNB2 CHRAC1 YTHDC1 PRDM16 L3MBTL3 PTMA	6.83e-09	896	71	17	GO:0006325
GeneOntologyBiologicalProcess	chromatin remodeling	NRDE2 PBRM1 ARID4B EHMT2 SUPT6H DPF3 NAP1L2 KDM2B SRPK2 DAXX LMNB2 CHRAC1 YTHDC1 PRDM16 L3MBTL3	2.62e-08	741	71	15	GO:0006338
GeneOntologyBiologicalProcess	protein-DNA complex organization	HMGN5 NRDE2 PBRM1 ARID4B EHMT2 SUPT6H DPF3 NAP1L2 KDM2B SRPK2 DAXX LMNB2 CHRAC1 YTHDC1 PRDM16 L3MBTL3 PTMA	3.39e-08	999	71	17	GO:0071824
GeneOntologyBiologicalProcess	ribonucleoprotein complex biogenesis	MDN1 EIF1AX NOM1 PES1 SRPK2 YTHDC1 DDX27 WDR43 DDX10	6.62e-05	515	71	9	GO:0022613
GeneOntologyCellularComponent	multi-eIF complex	EIF1AX EIF1AY	8.42e-05	4	79	2	GO:0043614
GeneOntologyCellularComponent	epsilon DNA polymerase complex	POLE CHRAC1	1.40e-04	5	79	2	GO:0008622
GeneOntologyCellularComponent	chromatin	HMGN5 SOX11 IRX5 PBRM1 ARID4B EHMT2 DPF3 NAP1L2 SRPK2 DAXX IRF6 CHRAC1 ZEB2 WDR43 FOXD4	3.81e-04	1480	79	15	GO:0000785
HumanPheno	Eclabion	SOX11 IRX5 MAP1B IRF6 CUL7 PUS7	2.56e-05	172	19	6	HP:0012472
Domain	DUF1220	NBPF3 NBPF9 NBPF11 NBPF1	3.14e-08	9	76	4	SM01148
Domain	NBPF_dom	NBPF3 NBPF9 NBPF11 NBPF1	8.17e-08	11	76	4	IPR010630
Domain	NBPF	NBPF3 NBPF9 NBPF11 NBPF1	8.17e-08	11	76	4	PS51316
Domain	DUF1220	NBPF3 NBPF9 NBPF11 NBPF1	8.17e-08	11	76	4	PF06758
Domain	TIF_eIF-1A_CS	EIF1AX EIF1AY	1.63e-05	2	76	2	IPR018104
Domain	TIF_eIF-1A	EIF1AX EIF1AY	4.89e-05	3	76	2	PD005579
Domain	IF1A	EIF1AX EIF1AY	4.89e-05	3	76	2	PS01262
Domain	-	SLTM ACIN1 XRCC6	8.17e-05	21	76	3	1.10.720.30
Domain	SAP	SLTM ACIN1 XRCC6	9.43e-05	22	76	3	PF02037
Domain	S1_IF1_TYPE	EIF1AX EIF1AY	9.75e-05	4	76	2	PS50832
Domain	eIF1a	EIF1AX EIF1AY	9.75e-05	4	76	2	SM00652
Domain	RNA-binding_domain_S1_IF1	EIF1AX EIF1AY	9.75e-05	4	76	2	IPR006196
Domain	eIF-1a	EIF1AX EIF1AY	9.75e-05	4	76	2	PF01176
Domain	TIF_eIF-1A	EIF1AX EIF1AY	9.75e-05	4	76	2	IPR001253
Domain	SAP	SLTM ACIN1 XRCC6	1.08e-04	23	76	3	SM00513
Domain	SAP	SLTM ACIN1 XRCC6	1.40e-04	25	76	3	PS50800
Domain	SAP_dom	SLTM ACIN1 XRCC6	1.40e-04	25	76	3	IPR003034
Domain	MIF4G	UPF2 NOM1	7.20e-04	10	76	2	SM00543
Domain	MIF4G	UPF2 NOM1	7.20e-04	10	76	2	PF02854
Domain	MIF4G-like_typ-3	UPF2 NOM1	7.20e-04	10	76	2	IPR003890
Domain	MIF4-like	UPF2 NOM1	1.66e-03	15	76	2	IPR016021
Domain	-	UPF2 NOM1	1.66e-03	15	76	2	1.25.40.180
Domain	ARM-type_fold	UPF2 NOM1 AP3B2 LRRK2 CUL7 VIRMA	2.57e-03	339	76	6	IPR016024
Domain	RNaseH-like_dom	SUPT6H POLE WRN	2.80e-03	69	76	3	IPR012337
Domain	DEAD/DEAH_box_helicase_dom	WRN DDX27 DDX10	3.28e-03	73	76	3	IPR011545
Domain	DEAD	WRN DDX27 DDX10	3.28e-03	73	76	3	PF00270
Domain	NA-bd_OB-fold	EIF1AX SUPT6H EIF1AY	4.71e-03	83	76	3	IPR012340
Domain	ARM-like	AP3B2 LRRK2 DAXX CUL7 ARMH4	4.88e-03	270	76	5	IPR011989
Domain	DEAD_ATP_HELICASE	DDX27 DDX10	7.04e-03	31	76	2	PS00039
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF3 NBPF8 NBPF12 NBPF9 NBPF10 NBPF11 NBPF1	2.95e-14	21	80	7	16079250
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PBRM1 MDN1 ARID4B MAP1B UPF2 NOM1 POLE WRN ACIN1 SRPK2 CUL7 L3MBTL3 VIRMA DDX27 XRCC6 WDR43 DDX10	1.36e-12	759	80	17	35915203
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NEFM PBRM1 MDN1 MAP1B SUPT6H POLE PES1 SLTM ACIN1 LMNB2 CUL7 VIRMA DDX27 XRCC6 WDR43 DDX10	1.76e-12	653	80	16	22586326
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	HMGN5 PBRM1 ARID4B EHMT2 PES1 WRN GPATCH11 ZBTB10 KDM2B BCCIP DAXX ZEB2 XRCC6 WDR43 DDX10	8.55e-12	608	80	15	36089195
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PBRM1 EHMT2 SUPT6H NOM1 POLE PES1 GPATCH11 SLTM ACIN1 YTHDC1 L3MBTL3 ZEB2 WDR43	5.74e-11	469	80	13	27634302
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF8 NBPF12 MAP1B NBPF9 AP3B2 LRRK2 GPATCH11 NBPF10 KDM2B NBPF11 CCDC136 XRCC6 NBPF1	1.72e-10	513	80	13	25798074
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	HMGN5 EIF1AX SUPT6H NOM1 PES1 NBPF10 SLTM ACIN1 SRPK2 YTHDC1 VIRMA DDX27 XRCC6 PUS7 DDX10	4.38e-10	807	80	15	22681889
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	HMGN5 PBRM1 MDN1 ZBTB17 ARID4B EHMT2 SUPT6H NOM1 WRN SLTM KDM2B ACIN1 LMNB2 CHRAC1 YTHDC1 L3MBTL3 XRCC6 WDR43	6.63e-10	1294	80	18	30804502
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TUBB6 NRDE2 PBRM1 MDN1 EHMT2 LONP2 EIF1AX SUPT6H NOM1 PES1 WRN KDM2B SRPK2 DAXX YTHDC1 VIRMA DDX27 WDR43 DDX10	9.36e-10	1497	80	19	31527615
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF12 NBPF9 NBPF1	5.39e-09	10	80	4	22973535
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NEFM MDN1 ARID4B MAP1B POLE PES1 ZBTB10 SRPK2 LMNB2 CUL7 YTHDC1 L3MBTL3 ZEB2 FOXD4	9.17e-09	857	80	14	25609649
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	NEFM ARID4B MAP1B UPF2 NOM1 SEC62 ACIN1 DAXX	1.48e-08	191	80	8	20195357
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	TUBB6 MDN1 SUPT6H PES1 SLTM ACIN1 DAXX LMNB2 CLSPN YTHDC1 DDX27 XRCC6 WDR43 DDX10	5.45e-08	989	80	14	36424410
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	TUBB6 PBRM1 MDN1 EHMT2 NOM1 PES1 SLTM ZBTB10 BCCIP ACIN1 SRPK2 YTHDC1 DDX27	6.78e-08	847	80	13	35850772
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PBRM1 MDN1 EHMT2 SUPT6H POLE PES1 SLTM BCCIP ACIN1 LMNB2 YTHDC1 VIRMA XRCC6 PUS7	7.40e-08	1014	80	14	32416067
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	NRDE2 PBRM1 UPF2 NOM1 SEC62 PES1 WRN GPATCH11 BCCIP ACIN1 SRPK2 VIRMA DDX27 XRCC6 WDR43 DDX10	7.77e-08	1371	80	16	36244648
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TUBB6 PBRM1 MDN1 MAP1B SUPT6H PES1 SLTM ACIN1 LMNB2 CUL7 DDX27 XRCC6 WDR43 DDX10	8.34e-08	1024	80	14	24711643
Pubmed	Human transcription factor protein interaction networks.	PBRM1 ARID4B EHMT2 DPF3 PES1 ZBTB10 KDM2B CUL7 PRDM16 L3MBTL3 DDX27 ZEB2 XRCC6 PTMA FBXW7 DDX10	1.37e-07	1429	80	16	35140242
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF8 NBPF12 MDN1 NBPF9 NBPF10 NBPF11 NBPF1	1.39e-07	170	80	7	23314748
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	HMGN5 TUBB6 PBRM1 MDN1 UPF2 PES1 PIP4K2A WRN BCCIP ACIN1 YTHDC1 DDX27 XRCC6 WDR43 DDX10	2.90e-07	1318	80	15	30463901
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TUBB6 NRDE2 DENND4A MAP1B UPF2 LONP2 NOM1 POLE SLTM SRPK2 CLSPN	2.91e-07	650	80	11	38777146
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	TUBB6 PBRM1 MDN1 EHMT2 NOM1 PES1 ACIN1 DAXX DDX27 DDX10	4.14e-07	533	80	10	30554943
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	PES1 SLTM ACIN1 SRPK2 LMNB2 VIRMA DDX27 XRCC6 WDR43 PTMA DDX10	9.22e-07	731	80	11	29298432
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	PBRM1 PES1 PIP4K2A ACIN1 YTHDC1 DDX27 WDR43 DDX10	1.01e-06	332	80	8	25693804
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	PBRM1 MDN1 NOM1 PES1 DAXX PRDM16 VIRMA	1.19e-06	234	80	7	36243803
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	PBRM1 MDN1 SUPT6H NOM1 PES1 ACIN1 VIRMA DDX27 XRCC6 DDX10	1.30e-06	605	80	10	28977666
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	MAP1B PES1 SLTM DAXX DDX27 XRCC6 WDR43 DDX10	1.47e-06	349	80	8	25665578
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MAP1B EHMT2 SUPT6H PES1 NBPF10 ACIN1 SRPK2 YTHDC1	1.77e-06	358	80	8	32460013
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TUBB6 MDN1 MAP1B UPF2 POLE PES1 PIP4K2A SLTM ZBTB10 ACIN1 LMNB2 DDX27 XRCC6 DDX10	2.32e-06	1353	80	14	29467282
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TUBB6 PBRM1 PES1 WRN ACIN1 XRCC6 DDX10	3.16e-06	271	80	7	32433965
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DENND4A PBRM1 MDN1 SUPT6H POLE PES1 SLTM BCCIP ACIN1 LMNB2 DDX27 XRCC6 WDR43 DDX10	4.23e-06	1425	80	14	30948266
Pubmed	Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.	NBPF11 NBPF1	5.23e-06	2	80	2	7700633
Pubmed	Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers.	POLE FBXW7	5.23e-06	2	80	2	27244218
Pubmed	Light chain 1 of microtubule-associated protein 1B can negatively regulate the action of Pes1.	MAP1B PES1	5.23e-06	2	80	2	17308336
Pubmed	MAP1B rescues LRRK2 mutant-mediated cytotoxicity.	MAP1B LRRK2	5.23e-06	2	80	2	24754922
Pubmed	Primary structural features of SR-like protein acinusS govern the phosphorylation mechanism by SRPK2.	ACIN1 SRPK2	5.23e-06	2	80	2	24444330
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	TUBB6 UPF2 NOM1 PES1 SLTM ACIN1 SRPK2 LMNB2 YTHDC1 VIRMA DDX27 XRCC6 WDR43	5.61e-06	1257	80	13	36526897
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	NEFM NRDE2 MAP1B UPF2 EIF1AX SUPT6H PES1 SLTM ACIN1 LMNB2 YTHDC1 XRCC6	6.65e-06	1082	80	12	38697112
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	PES1 ACIN1 YTHDC1 DDX27 XRCC6 WDR43 DDX10 EIF1AY	6.82e-06	430	80	8	38172120
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TUBB6 MDN1 EHMT2 SUPT6H POLE PES1 TMX4 BCCIP SRPK2 LMNB2 DDX27 XRCC6 PUS7 DDX10	6.87e-06	1487	80	14	33957083
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	EHMT2 POLE ZBTB10 CLSPN ZEB2	7.45e-06	116	80	5	30804394
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZBTB17 ARID4B EHMT2 NOM1 POLE ZBTB10 ACIN1 LMNB2 XRCC6	7.92e-06	583	80	9	29844126
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUBB6 PBRM1 ARID4B EHMT2 DPF3 PIP4K2A ZBTB10 SRPK2 CUL7 CLSPN PRDM16 PTMA	9.07e-06	1116	80	12	31753913
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	PBRM1 MAP1B NOM1 DDX27 XRCC6 PUS7	1.07e-05	215	80	6	35973513
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	PBRM1 NOM1 ZBTB10 ACIN1 SRPK2 YTHDC1 DDX10	1.14e-05	330	80	7	33301849
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	PES1 KDM2B CLSPN L3MBTL3 XRCC6 WDR43 DDX10	1.36e-05	339	80	7	30415952
Pubmed	Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.	PBRM1 FBXW7	1.57e-05	3	80	2	32396860
Pubmed	Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization.	NEFM MAP1B	1.57e-05	3	80	2	11581286
Pubmed	A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.	WRN XRCC6	1.57e-05	3	80	2	11328876
Pubmed	Ku complex interacts with and stimulates the Werner protein.	WRN XRCC6	1.57e-05	3	80	2	10783163
Pubmed	Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.	WRN XRCC6	1.57e-05	3	80	2	12177300
Pubmed	Functional interaction between Ku and the werner syndrome protein in DNA end processing.	WRN XRCC6	1.57e-05	3	80	2	10880505
Pubmed	LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.	MAP1B LRRK2	1.57e-05	3	80	2	21159966
Pubmed	The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.	EIF1AX EIF1AY	1.57e-05	3	80	2	24319994
Pubmed	VIRMA contributes to non-small cell lung cancer progression via N6-methyladenosine-dependent DAPK3 post-transcriptional modification.	YTHDC1 VIRMA	1.57e-05	3	80	2	34520821
Pubmed	KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.	YTHDC1 VIRMA	1.57e-05	3	80	2	38224863
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	TUBB6 PBRM1 PES1 SRPK2 DDX27 XRCC6 WDR43 DDX10	1.58e-05	483	80	8	36912080
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	MAP1B LONP2 POLE CLSPN STK11IP FBXW7	1.64e-05	232	80	6	25515538
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HMGN5 PBRM1 ZBTB17 DPF3 SLTM ACIN1 IRF6 CHRAC1 PRDM16 XRCC6	1.65e-05	808	80	10	20412781
Pubmed	Interaction network of human early embryonic transcription factors.	PBRM1 ARID4B EHMT2 DPF3 KDM2B PRDM16 ZEB2	1.70e-05	351	80	7	38297188
Pubmed	Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation.	NEFM EIF1AX EIF1AY	1.75e-05	22	80	3	30951662
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	SUPT6H SEC62 SLTM BCCIP SRPK2 DAXX DDX27 XRCC6 PUS7	1.94e-05	653	80	9	33742100
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	PBRM1 MDN1 ARID4B EHMT2 SUPT6H	2.59e-05	150	80	5	28242625
Pubmed	The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin.	AP3B2 PLIN1	3.13e-05	4	80	2	11641724
Pubmed	RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control.	SUPT6H WDR43	3.13e-05	4	80	2	31128943
Pubmed	Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1.	WRN XRCC6	3.13e-05	4	80	2	14734561
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	PBRM1 EHMT2 DPF3 KDM2B CHRAC1	3.22e-05	157	80	5	30186101
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	POLE ACIN1 DAXX CLSPN XRCC6	3.22e-05	157	80	5	30686591
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	PBRM1 MDN1 MAP1B PES1 DAXX DDX27 XRCC6	3.54e-05	394	80	7	27248496
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	MAP1B LONP2 PES1 ACIN1 SRPK2 LMNB2 DDX27	4.56e-05	410	80	7	26949251
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	MDN1 EHMT2 NOM1 ZBTB10 CUL7 ZEB2	4.90e-05	282	80	6	23667531
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	WRN GPATCH11 ACIN1 XRCC6 WDR43 DDX10	4.99e-05	283	80	6	30585729
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NEFM EHMT2 ZBTB10 KDM2B L3MBTL3 ZEB2 EIF1AY	5.15e-05	418	80	7	34709266
Pubmed	The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin.	MDN1 PES1	5.20e-05	5	80	2	26601951
Pubmed	Characterization of functional domains in human Claspin.	POLE CLSPN	5.20e-05	5	80	2	21478680
Pubmed	Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags.	LRRK2 GPATCH11	5.20e-05	5	80	2	12213963
Pubmed	Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.	PBRM1 CLSPN	5.20e-05	5	80	2	16934469
Pubmed	Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.	NBPF11 NBPF1	5.20e-05	5	80	2	20096688
Pubmed	The functional interactome landscape of the human histone deacetylase family.	MDN1 ARID4B EHMT2 PES1 ACIN1 DDX27	5.61e-05	289	80	6	23752268
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	TUBB6 PBRM1 SUPT6H ZBTB10 SRPK2 DAXX DDX27	7.10e-05	440	80	7	34244565
Pubmed	Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners.	MAP1B PIP4K2A ACIN1 LMNB2 EIF1AY	7.20e-05	186	80	5	31540324
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NEFM TUBB6 PBRM1 MDN1 EHMT2 SRPK2 LMNB2 VIRMA ZEB2 XRCC6	7.22e-05	963	80	10	28671696
Pubmed	The ACF1 complex is required for DNA double-strand break repair in human cells.	CHRAC1 XRCC6	7.79e-05	6	80	2	21172662
Pubmed	Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.	ACIN1 SRPK2	7.79e-05	6	80	2	19592491
Pubmed	A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.	TUBB6 LRRK2	7.79e-05	6	80	2	24275654
Pubmed	Structural basis for the nuclear export activity of Importin13.	EIF1AX EIF1AY	7.79e-05	6	80	2	23435562
Pubmed	Screening of LRRK2 interactants by yeast 2-hybrid analysis.	LRRK2 L3MBTL3	7.79e-05	6	80	2	19001729
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	TUBB6 MDN1 DAXX XRCC6	1.08e-04	106	80	4	19394292
Pubmed	Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.	CUL7 FBXW7	1.09e-04	7	80	2	12904573
Pubmed	The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.	CUL7 FBXW7	1.09e-04	7	80	2	24362026
Pubmed	A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron.	XRCC6 FBXW7	1.09e-04	7	80	2	18784078
Pubmed	Maternal epigenetic factors in embryonic and postnatal development.	KDM2B PRDM16	1.09e-04	7	80	2	36906847
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NEFM DENND4A MDN1 MAP1B SEC62 PES1 PIP4K2A ACIN1 LMNB2 PLIN1 ZEB2 XRCC6	1.09e-04	1442	80	12	35575683
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PBRM1 ARID4B MAP1B EHMT2 PIP4K2A SLTM L3MBTL3 XRCC6	1.20e-04	645	80	8	25281560
Pubmed	Directed proteomic analysis of the human nucleolus.	ARID4B PES1 DDX27 XRCC6 DDX10	1.22e-04	208	80	5	11790298
Pubmed	A family of mammalian F-box proteins.	KDM2B CUL7 FBXW7	1.26e-04	42	80	3	10531037
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	TUBB6 NOM1 PES1 ACIN1 SRPK2 LMNB2 DDX27 XRCC6	1.34e-04	655	80	8	35819319
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	NEFM PBRM1 MDN1 UPF2 SUPT6H AP3B2 PIP4K2A SRPK2 XRCC6	1.43e-04	847	80	9	35235311
Pubmed	The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis.	PBRM1 L3MBTL3	1.45e-04	8	80	2	36335117
Pubmed	PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading.	KDM2B XRCC6	1.45e-04	8	80	2	29985131
Interaction	ZNF330 interactions	PBRM1 ARID4B SUPT6H POLE PES1 ZBTB10 KDM2B SRPK2 YTHDC1 L3MBTL3 VIRMA DDX27 XRCC6 PUS7 WDR43 DDX10	1.52e-11	446	79	16	int:ZNF330
Interaction	H3C1 interactions	HMGN5 SOX11 PBRM1 ARID4B EHMT2 DPF3 PES1 LRRK2 ZBTB10 KDM2B BCCIP DAXX PABPN1L PRDM16 L3MBTL3 VIRMA DDX27 XRCC6 PUS7 DDX10	1.80e-10	901	79	20	int:H3C1
Interaction	DDX23 interactions	NEFM MAP1B SUPT6H PES1 PIP4K2A SLTM ACIN1 SRPK2 CUL7 YTHDC1 VIRMA DDX27 WDR43 FBXW7 DDX10	4.83e-10	480	79	15	int:DDX23
Interaction	DHX40 interactions	SUPT6H NOM1 SLTM ZBTB10 LMNB2 CLSPN YTHDC1 VIRMA DDX27 TRIM52 DDX10	3.54e-09	249	79	11	int:DHX40
Interaction	NEK4 interactions	NBPF8 NBPF12 MAP1B NBPF9 AP3B2 LRRK2 GPATCH11 NBPF10 KDM2B ACIN1 NBPF11 VIRMA CCDC136 XRCC6 NBPF1	6.63e-09	582	79	15	int:NEK4
Interaction	CSNK2B interactions	CCDC82 EHMT2 DPF3 PIP4K2A ZBTB10 BCCIP DAXX CUL7 CLSPN YTHDC1 PRDM16 L3MBTL3 ZEB2 FBXW7 DDX10	1.72e-08	625	79	15	int:CSNK2B
Interaction	PARP1 interactions	HMGN5 PBRM1 MDN1 ARID4B SUPT6H POLE PES1 WRN ZBTB10 KDM2B DAXX CUL7 CHRAC1 CLSPN YTHDC1 PRDM16 VIRMA DDX27 XRCC6 WDR43 DDX10	2.13e-08	1316	79	21	int:PARP1
Interaction	ELK3 interactions	PBRM1 ARID4B EHMT2 ZBTB10 KDM2B PRDM16 ZEB2 FBXW7	2.29e-08	120	79	8	int:ELK3
Interaction	SIRT7 interactions	NEFM PBRM1 MDN1 MAP1B SUPT6H POLE PES1 SLTM ACIN1 LMNB2 CUL7 VIRMA DDX27 XRCC6 WDR43 DDX10	2.49e-08	744	79	16	int:SIRT7
Interaction	HECTD1 interactions	PBRM1 MDN1 ARID4B MAP1B UPF2 NOM1 POLE WRN ACIN1 SRPK2 CUL7 L3MBTL3 VIRMA DDX27 XRCC6 WDR43 FBXW7 DDX10	3.49e-08	984	79	18	int:HECTD1
Interaction	POLR1G interactions	PBRM1 MDN1 ARID4B SUPT6H PES1 ZBTB10 KDM2B CLSPN DDX27 ZEB2 XRCC6 WDR43 DDX10	5.29e-08	489	79	13	int:POLR1G
Interaction	SSRP1 interactions	PBRM1 CCDC82 SUPT6H POLE SLTM ACIN1 DAXX CUL7 CHRAC1 CLSPN YTHDC1 PRDM16 VIRMA XRCC6 FBXW7	5.74e-08	685	79	15	int:SSRP1
Interaction	KLF12 interactions	PBRM1 ARID4B EHMT2 KDM2B PRDM16 L3MBTL3 VIRMA DDX27 ZEB2	6.79e-08	194	79	9	int:KLF12
Interaction	TOP1 interactions	PBRM1 ARID4B SUPT6H POLE PES1 SLTM ACIN1 SRPK2 CUL7 CHRAC1 YTHDC1 PRDM16 VIRMA XRCC6 FBXW7	7.07e-08	696	79	15	int:TOP1
Interaction	BAZ1B interactions	HMGN5 EIF1AX SUPT6H DAXX CUL7 PRDM16 VIRMA XRCC6 FBXW7	1.04e-07	204	79	9	int:BAZ1B
Interaction	EED interactions	HMGN5 NRDE2 PBRM1 ARID4B MAP1B EHMT2 SUPT6H NOM1 PES1 SLTM KDM2B ACIN1 SRPK2 LMNB2 CUL7 CHRAC1 VIRMA DDX27 XRCC6 WDR43 DDX10	1.06e-07	1445	79	21	int:EED
Interaction	NIFK interactions	MDN1 EHMT2 NOM1 PES1 SRPK2 CUL7 YTHDC1 DDX27 XRCC6 WDR43 FBXW7 DDX10	1.10e-07	431	79	12	int:NIFK
Interaction	CSNK2A1 interactions	DENND4A ARID4B CCDC82 EHMT2 SUPT6H DPF3 PES1 PIP4K2A ZBTB10 KDM2B ACIN1 DAXX CUL7 PRDM16 ZEB2 CCDC116 XRCC6	1.35e-07	956	79	17	int:CSNK2A1
Interaction	SUPT16H interactions	CCDC82 SUPT6H PES1 WRN ACIN1 SRPK2 DAXX CUL7 PRDM16 VIRMA XRCC6 FBXW7	1.45e-07	442	79	12	int:SUPT16H
Interaction	H3-3A interactions	HMGN5 PBRM1 ARID4B EHMT2 DPF3 LRRK2 WRN GPATCH11 ZBTB10 KDM2B BCCIP DAXX ZEB2 XRCC6 DDX10	1.83e-07	749	79	15	int:H3-3A
Interaction	DNAJB6 interactions	TUBB6 MAP1B SUPT6H PES1 LRRK2 BCCIP LMNB2 PRDM16 DDX27 FBXW7 DDX10	2.59e-07	379	79	11	int:DNAJB6
Interaction	XRCC5 interactions	HMGN5 POLE PIP4K2A WRN KDM2B SRPK2 LMNB2 CUL7 CHRAC1 PRDM16 VIRMA XRCC6	7.38e-07	515	79	12	int:XRCC5
Interaction	TOP2A interactions	HMGN5 PBRM1 POLE SRPK2 DAXX LMNB2 CUL7 L3MBTL3 VIRMA TRIM52 XRCC6 FBXW7	8.17e-07	520	79	12	int:TOP2A
Interaction	MYB interactions	UPF2 EHMT2 ZBTB10 KDM2B VIRMA ZEB2 FBXW7	9.08e-07	133	79	7	int:MYB
Interaction	KLF5 interactions	PBRM1 ZBTB17 ARID4B EHMT2 ZBTB10 KDM2B DDX27 FBXW7	9.65e-07	195	79	8	int:KLF5
Interaction	MYCN interactions	NEFM ZBTB17 MAP1B UPF2 DPF3 NOM1 PES1 SLTM ACIN1 SRPK2 DAXX CUL7 YTHDC1 VIRMA DDX27 XRCC6 WDR43 FBXW7 DDX10	1.04e-06	1373	79	19	int:MYCN
Interaction	ZC3H18 interactions	PES1 SLTM ACIN1 SRPK2 DAXX LMNB2 CUL7 YTHDC1 VIRMA DDX27 XRCC6 WDR43 PTMA FBXW7 DDX10	1.34e-06	877	79	15	int:ZC3H18
Interaction	COIL interactions	PBRM1 EHMT2 SUPT6H LRRK2 ZBTB10 KDM2B SRPK2 DAXX YTHDC1 L3MBTL3 CCDC136 XRCC6	1.53e-06	552	79	12	int:COIL
Interaction	KLF9 interactions	PBRM1 ARID4B EHMT2 DDX27 FBXW7 DDX10	1.74e-06	93	79	6	int:KLF9
Interaction	MEN1 interactions	TUBB6 PBRM1 MDN1 UPF2 EHMT2 NOM1 PES1 SLTM ZBTB10 BCCIP ACIN1 SRPK2 DAXX YTHDC1 DDX27 DDX10	1.97e-06	1029	79	16	int:MEN1
Interaction	RPL31 interactions	SUPT6H NOM1 PES1 WRN ACIN1 SRPK2 YTHDC1 VIRMA DDX27 XRCC6 WDR43 FBXW7 DDX10	2.23e-06	680	79	13	int:RPL31
Interaction	DOT1L interactions	TUBB6 PBRM1 MDN1 EHMT2 NOM1 PES1 SLTM BCCIP ACIN1 SRPK2 DAXX YTHDC1 VIRMA DDX27	2.70e-06	807	79	14	int:DOT1L
Interaction	H2BC21 interactions	PBRM1 ARID4B MAP1B EHMT2 SUPT6H DAXX CUL7 CHRAC1 L3MBTL3 VIRMA XRCC6 PTMA FBXW7	2.88e-06	696	79	13	int:H2BC21
Interaction	CHD4 interactions	PBRM1 MDN1 EHMT2 SUPT6H NOM1 PES1 ACIN1 DAXX CUL7 PRDM16 VIRMA DDX27 XRCC6 FBXW7 DDX10	3.08e-06	938	79	15	int:CHD4
Interaction	IRF8 interactions	ZBTB17 ARID4B EHMT2 ZBTB10 IRF6	3.17e-06	58	79	5	int:IRF8
Interaction	NBPF3 interactions	NBPF3 VIRMA NBPF1	3.20e-06	8	79	3	int:NBPF3
Interaction	H3C3 interactions	PBRM1 EHMT2 SUPT6H PES1 ZBTB10 KDM2B BCCIP DAXX ZEB2 XRCC6 WDR43	3.52e-06	495	79	11	int:H3C3
Interaction	IFI16 interactions	PBRM1 MAP1B PES1 PIP4K2A SLTM ACIN1 YTHDC1 VIRMA DDX27 XRCC6 WDR43 FBXW7 DDX10	3.80e-06	714	79	13	int:IFI16
Interaction	PHRF1 interactions	SUPT6H ACIN1 CUL7 VIRMA XRCC6	4.08e-06	61	79	5	int:PHRF1
Interaction	AFF4 interactions	PES1 PIP4K2A LRRK2 DAXX VIRMA XRCC6	6.00e-06	115	79	6	int:AFF4
Interaction	KLF16 interactions	ARID4B EHMT2 PES1 ZBTB10 KDM2B L3MBTL3 DDX27 ZEB2 PTMA DDX10	6.16e-06	425	79	10	int:KLF16
Interaction	RNPS1 interactions	NRDE2 UPF2 SUPT6H PES1 PIP4K2A ACIN1 SRPK2 DAXX CUL7 YTHDC1	6.16e-06	425	79	10	int:RNPS1
Interaction	RPS6 interactions	UPF2 NOM1 PES1 SLTM BCCIP SRPK2 DAXX CUL7 VIRMA DDX27 XRCC6 WDR43 FBXW7 DDX10	6.76e-06	874	79	14	int:RPS6
Interaction	H3C2 interactions	EHMT2 SUPT6H DAXX VIRMA XRCC6	7.00e-06	68	79	5	int:H3C2
Interaction	RICTOR interactions	TUBB6 PBRM1 MAP1B EHMT2 NOM1 LMNB2 CHRAC1 VIRMA DDX27 TRIM52 XRCC6 PUS7 FBXW7	7.36e-06	759	79	13	int:RICTOR
Interaction	SOX2 interactions	PBRM1 MDN1 ARID4B MAP1B EHMT2 NOM1 PES1 WRN SLTM ZBTB10 KDM2B SRPK2 LMNB2 CUL7 L3MBTL3 DDX27 ZEB2 XRCC6	7.41e-06	1422	79	18	int:SOX2
Interaction	FGFBP1 interactions	PBRM1 NOM1 SLTM SRPK2 VIRMA DDX27 WDR43 DDX10	7.49e-06	257	79	8	int:FGFBP1
Interaction	LHX2 interactions	PBRM1 ARID4B EHMT2 KDM2B L3MBTL3 DDX27 ZEB2	7.58e-06	183	79	7	int:LHX2
Interaction	CBX3 interactions	HMGN5 EHMT2 LRRK2 KDM2B DAXX CUL7 CLSPN PRDM16 VIRMA XRCC6 PUS7 WDR43	7.64e-06	646	79	12	int:CBX3
Interaction	MKI67 interactions	MAP1B LONP2 PES1 ACIN1 SRPK2 DAXX LMNB2 CUL7 VIRMA DDX27 XRCC6 PTMA	7.88e-06	648	79	12	int:MKI67
Interaction	H2BC4 interactions	NEFM MAP1B UPF2 EIF1AX SLTM VIRMA DDX27 XRCC6	7.93e-06	259	79	8	int:H2BC4
Interaction	TOP2B interactions	HMGN5 SRPK2 DAXX CUL7 VIRMA TRIM52 XRCC6 FBXW7	9.63e-06	266	79	8	int:TOP2B
Interaction	OBSL1 interactions	PBRM1 MDN1 SUPT6H PES1 SLTM ACIN1 DAXX LMNB2 CUL7 YTHDC1 DDX27 XRCC6 WDR43 DDX10	9.66e-06	902	79	14	int:OBSL1
Interaction	MSH6 interactions	PBRM1 POLE CUL7 CLSPN YTHDC1 VIRMA XRCC6 FBXW7	1.10e-05	271	79	8	int:MSH6
Interaction	ZRANB2 interactions	PIP4K2A LRRK2 BCCIP ACIN1 SRPK2 CUL7 XRCC6	1.31e-05	199	79	7	int:ZRANB2
Interaction	H3C10 interactions	EHMT2 SUPT6H DAXX VIRMA	1.46e-05	38	79	4	int:H3C10
Interaction	H2BC8 interactions	PBRM1 ARID4B EHMT2 KDM2B L3MBTL3 VIRMA XRCC6 PUS7 WDR43 PTMA DDX10	1.47e-05	576	79	11	int:H2BC8
Interaction	FEV interactions	PBRM1 ARID4B EHMT2 ZBTB10 KDM2B L3MBTL3 ZEB2	1.49e-05	203	79	7	int:FEV
Interaction	SOX7 interactions	PBRM1 KDM2B PRDM16 ZEB2 FBXW7	1.75e-05	82	79	5	int:SOX7
Interaction	BRCA2 interactions	POLE LRRK2 BCCIP ACIN1 DAXX CLSPN VIRMA TRIM52 XRCC6	1.91e-05	384	79	9	int:BRCA2
Interaction	ADARB1 interactions	TUBB6 PBRM1 PES1 WRN ACIN1 SRPK2 YTHDC1 DDX27 XRCC6 DDX10	2.08e-05	489	79	10	int:ADARB1
Interaction	MLLT3 interactions	PES1 PIP4K2A LRRK2 DAXX VIRMA	2.09e-05	85	79	5	int:MLLT3
Interaction	CSNK2A2 interactions	ARID4B CCDC82 DPF3 PES1 PIP4K2A ZBTB10 KDM2B DAXX PRDM16 VIRMA ZEB2 FBXW7	2.19e-05	718	79	12	int:CSNK2A2
Interaction	FBXO38 interactions	EHMT2 POLE ZBTB10 CLSPN VIRMA ZEB2	2.26e-05	145	79	6	int:FBXO38
Interaction	RCOR1 interactions	NEFM HMGN5 EHMT2 KDM2B YTHDC1 PRDM16 L3MBTL3 VIRMA ZEB2 FBXW7	2.27e-05	494	79	10	int:RCOR1
Interaction	SENP3 interactions	NEFM PBRM1 MDN1 SLTM ACIN1 DAXX PRDM16 DDX27	2.35e-05	301	79	8	int:SENP3
Interaction	EIF4A3 interactions	MAP1B UPF2 EHMT2 NOM1 WRN ACIN1 SRPK2 CUL7 YTHDC1 FBXW7	2.47e-05	499	79	10	int:EIF4A3
Interaction	FOXK2 interactions	ARID4B MAP1B SEC62 ZBTB10 SRPK2 YTHDC1 VIRMA	2.89e-05	225	79	7	int:FOXK2
Interaction	NFIX interactions	PBRM1 ARID4B EHMT2 ZBTB10 KDM2B L3MBTL3 ZEB2	3.05e-05	227	79	7	int:NFIX
Interaction	TNRC18 interactions	ARID4B PES1 DAXX VIRMA XRCC6	3.07e-05	92	79	5	int:TNRC18
Interaction	NUP43 interactions	PBRM1 ARID4B SUPT6H WRN ZBTB10 ACIN1 CUL7 YTHDC1 VIRMA DDX27 WDR43	3.12e-05	625	79	11	int:NUP43
Interaction	DNAJC8 interactions	EHMT2 EIF1AX PES1 GPATCH11 SRPK2 PUS7 DDX10	3.32e-05	230	79	7	int:DNAJC8
Interaction	H3C14 interactions	EHMT2 DPF3 KDM2B CUL7 PRDM16 PTMA	3.41e-05	156	79	6	int:H3C14
Interaction	GAR1 interactions	SRPK2 DAXX CUL7 DDX27 PUS7 WDR43 FBXW7	3.51e-05	232	79	7	int:GAR1
Interaction	UBTF interactions	PES1 PIP4K2A SRPK2 DAXX CUL7 VIRMA FBXW7	3.71e-05	234	79	7	int:UBTF
Interaction	SMC1A interactions	HMGN5 EHMT2 POLE BCCIP ACIN1 CUL7 VIRMA XRCC6 FBXW7	3.72e-05	418	79	9	int:SMC1A
Interaction	H2BC12 interactions	HMGN5 MAP1B UPF2 EIF1AX SLTM SRPK2 VIRMA DDX27	3.79e-05	322	79	8	int:H2BC12
Interaction	FBL interactions	NOM1 PES1 NAP1L2 SRPK2 CUL7 DDX27 XRCC6 PUS7 WDR43 FBXW7 DDX10	3.81e-05	639	79	11	int:FBL
Interaction	RPS19 interactions	MAP1B NOM1 LRRK2 GPATCH11 SRPK2 DAXX VIRMA DDX27 XRCC6 FBXW7 DDX10	3.81e-05	639	79	11	int:RPS19
Interaction	SOX9 interactions	PBRM1 ARID4B KDM2B VIRMA FBXW7	3.96e-05	97	79	5	int:SOX9
Interaction	SUZ12 interactions	HMGN5 PBRM1 EHMT2 NOM1 PES1 SLTM ACIN1 LMNB2 YTHDC1 L3MBTL3 VIRMA	4.09e-05	644	79	11	int:SUZ12
Interaction	KLF8 interactions	PBRM1 ARID4B EHMT2 KDM2B L3MBTL3 DDX27 ZEB2 PTMA	4.42e-05	329	79	8	int:KLF8
Interaction	HSP90B1 interactions	MAP1B UPF2 SUPT6H SEC62 LRRK2 SLTM CUL7 VIRMA XRCC6 PTMA FBXW7	4.45e-05	650	79	11	int:HSP90B1
Interaction	GLUD1P3 interactions	YTHDC1 VIRMA	4.54e-05	3	79	2	int:GLUD1P3
Interaction	C11orf58 interactions	HMGN5 MAP1B ACIN1 XRCC6 PTMA	4.81e-05	101	79	5	int:C11orf58
Interaction	LHX1 interactions	PBRM1 EHMT2 ZBTB10 KDM2B DDX27	5.28e-05	103	79	5	int:LHX1
Interaction	H3C4 interactions	DPF3 YTHDC1 VIRMA	5.37e-05	19	79	3	int:H3C4
Interaction	SMARCAL1 interactions	WRN CLSPN YTHDC1 VIRMA	5.53e-05	53	79	4	int:SMARCAL1
Interaction	MAX interactions	ZBTB17 ARID4B EHMT2 PIP4K2A DAXX XRCC6 FBXW7	5.78e-05	251	79	7	int:MAX
Interaction	H4C12 interactions	EHMT2 DAXX CUL7 VIRMA	5.96e-05	54	79	4	int:H4C12
Interaction	CIC interactions	ZBTB17 ARID4B EHMT2 NOM1 POLE SEC62 ZBTB10 ACIN1 LMNB2 VIRMA XRCC6	6.09e-05	673	79	11	int:CIC
Interaction	NAP1L1 interactions	EIF1AX PES1 NAP1L2 CUL7 PRDM16 VIRMA WDR43 FBXW7	6.17e-05	345	79	8	int:NAP1L1
Interaction	CRX interactions	PBRM1 ARID4B EHMT2 DPF3 KDM2B PRDM16 ZEB2	6.23e-05	254	79	7	int:CRX
Interaction	TLX1 interactions	PBRM1 ARID4B EHMT2 KDM2B ZEB2 XRCC6	6.47e-05	175	79	6	int:TLX1
Interaction	ZBTB2 interactions	PBRM1 NOM1 ZBTB10 ACIN1 SRPK2 DAXX YTHDC1 PUS7 DDX10	6.57e-05	450	79	9	int:ZBTB2
Interaction	TEAD1 interactions	PBRM1 ARID4B EHMT2 KDM2B L3MBTL3 ZEB2	6.68e-05	176	79	6	int:TEAD1
Interaction	SPEN interactions	PIP4K2A SRPK2 DAXX CUL7 VIRMA XRCC6	7.11e-05	178	79	6	int:SPEN
Interaction	RPS10 interactions	NRDE2 NOM1 LRRK2 SRPK2 CUL7 VIRMA DDX27 XRCC6 FBXW7 DDX10	7.23e-05	567	79	10	int:RPS10
Interaction	RIT1 interactions	MDN1 EHMT2 EIF1AX SUPT6H POLE PES1 LRRK2 NBPF10 BCCIP SRPK2 CLSPN YTHDC1 XRCC6 WDR43 DDX10	7.48e-05	1230	79	15	int:RIT1
Interaction	RBBP4 interactions	HMGN5 ARID4B EHMT2 KDM2B CUL7 PRDM16 VIRMA ZEB2 XRCC6 FBXW7	7.89e-05	573	79	10	int:RBBP4
Cytoband	1q21.1	NBPF8 NBPF9 NBPF10 NBPF11	4.42e-06	62	80	4	1q21.1
GeneFamily	Neuroblastoma breakpoint family	NBPF3 NBPF8 NBPF12 NBPF9 NBPF10 NBPF11 NBPF1	1.40e-13	23	48	7	662
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	HMGN5 NRDE2 MAP1B UPF2 SLTM CLSPN YTHDC1 DDX27	2.59e-09	197	80	8	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	SOX11 ARID4B MAP1B EIF1AX ZEB2 PTMA	1.54e-06	198	80	6	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF12 MDN1 NBPF10 NBPF11 NBPF1	1.27e-05	167	80	5	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	Mild/Remission-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TUBB6 ARID4B ZBTB10 ZEB2 PTMA	1.51e-05	173	80	5	694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM MAP1B AP3B2 PABPN1L CCDC136	1.83e-05	180	80	5	9db9899ca42455310e9b63df523fe6c4780abfb7
ToppCell	Bronchial_Biopsy-Mesenchymal-Smooth_muscle\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	NEFM THBS2 DPF3 HRC ZEB2	1.83e-05	180	80	5	7085a851807e6a833965e1366946db0bbc5174e2
ToppCell	droplet-Marrow-nan-3m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM2B L3MBTL3 ZEB2 WDR43 DDX10	1.98e-05	183	80	5	92ef926e6c1de8477fa4f35d1dae85482d8009de
ToppCell	droplet-Marrow-nan-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM2B L3MBTL3 ZEB2 WDR43 DDX10	1.98e-05	183	80	5	24db9cc717e651586317c6a8e03a3401651273c1
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NEFM CLSPN ZEB2 WDR43 PTMA	1.98e-05	183	80	5	523896bd1a93bdda81a009768baa3a1bdbd108b8
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TUBB6 PIP4K2A LRRK2 NBPF10 ZEB2	1.98e-05	183	80	5	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NBPF8 UPF2 LRRK2 PRDM16 ZEB2	2.14e-05	186	80	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PBRM1 ARID4B MAP1B SEC62 SLTM	2.25e-05	188	80	5	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PBRM1 ZBTB10 PUS7 PTMA DDX10	2.37e-05	190	80	5	36e83995021ba16690f84e2077a9e8baec547d05
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PBRM1 ZBTB10 PUS7 PTMA DDX10	2.37e-05	190	80	5	d26be9e1b676f750e716b91ebc3598fac3735612
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	TUBB6 DENND4A ARID4B WRN YTHDC1	2.43e-05	191	80	5	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	DENND4A WRN ZBTB10 YTHDC1 PTMA	2.49e-05	192	80	5	aee6522d25e012231cdb905ce047295cb64d6e82
ToppCell	HSPCs-Ery_prog.\|World / Lineage and Cell class	PES1 WRN DDX27 PUS7 WDR43	2.55e-05	193	80	5	484c2e0daedc6cb0d50d164add8c1658123a60f9
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NRDE2 SEC62 GPATCH11 CLSPN WDR43	2.62e-05	194	80	5	40c6e17e9e48d4fa6da3a0a1066c4c6565a1e096
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	SOX11 MAP1B ZEB2 PTMA	2.72e-05	96	80	4	56e993d37b7958abe56682422536045550e29b41
ToppCell	COVID-19_Severe-PLT_4\|World / Disease Group and Platelet Clusters	DENND4A ARID4B UPF2 SEC62 EIF1AY	2.75e-05	196	80	5	ad43efdd4d73b6615f65f06a315b33576e317473
ToppCell	P03-Mesenchymal-myocytic_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SOX11 THBS2 MAP1B IBSP PTMA	2.82e-05	197	80	5	079db904a08743b3c555cb7b3f5fb5c978dde25a
ToppCell	Neuron\|World / Primary Cells by Cluster	NEFM SOX11 MAP1B ZEB2 FBXW7	2.96e-05	199	80	5	1f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCell	Neuron-Postmitotic\|World / Primary Cells by Cluster	NEFM SOX11 MAP1B ZEB2 FBXW7	2.96e-05	199	80	5	1973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	NEFM SOX11 MAP1B ZEB2 PTMA	2.96e-05	199	80	5	1029f3458b7fda464aa0e7ef06e081e2618c1388
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal-PNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	NEFM SOX11 MAP1B ZEB2 PTMA	2.96e-05	199	80	5	8a04398653a1794921d73a6a950c1fb6fdf68c85
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	NEFM SOX11 MAP1B ZEB2 FBXW7	2.96e-05	199	80	5	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-Neurons\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	NEFM SOX11 MAP1B YTHDC1 PTMA	3.03e-05	200	80	5	b9538eb33ac86384e7e289a5a82fac4d56a7b9c2
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	SOX11 MAP1B ZEB2 PTMA	4.97e-05	112	80	4	9c3fb470708e76a8f8a3cb9aa17ab130c60fee11
Computational	Genes in the cancer module 318.	WRN XRCC6 DDX10	1.82e-04	28	43	3	MODULE_318
Computational	Genes in the cancer module 229.	WRN XRCC6 DDX10	2.48e-04	31	43	3	MODULE_229
Drug	Pesticides	NBPF8 NEFM NBPF12 NBPF9 NBPF10 NBPF11 NBPF1	9.94e-07	150	80	7	ctd:D010575
Drug	AC1O5Y0F	NEFM TUBB6 ARID4B MAP1B	8.54e-06	37	80	4	CID006442852
Disease	uveal melanoma (implicated_via_orthology)	EIF1AX EIF1AY	5.71e-06	2	71	2	DOID:6039 (implicated_via_orthology)
Disease	Short Stature, CTCAE	RSPH4A PUS7	2.54e-04	10	71	2	C2919142
Disease	Short stature	RSPH4A PUS7	2.54e-04	10	71	2	C0349588
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	DPF3 WRN SRPK2 DDX27 XRCC6 PUS7	3.97e-04	398	71	6	EFO_0003756, EFO_0003888, EFO_0004337
Disease	Hypodontia	IRX5 IRF6	5.10e-04	14	71	2	C0020608
Disease	caffeine measurement	LRRK2 LMNB2	5.87e-04	15	71	2	EFO_0021177
Disease	Cleft palate	IRF6 CHRAC1 VIRMA	6.79e-04	71	71	3	HP_0000175
Disease	Malignant neoplasm of endometrium	POLE FBXW7	8.52e-04	18	71	2	C0007103
Disease	Carcinoma in situ of endometrium	POLE FBXW7	8.52e-04	18	71	2	C0346191
Disease	Colorectal Carcinoma	MAP1B POLE WRN ACIN1 LMNB2 ZEB2 FBXW7	1.49e-03	702	71	7	C0009402
Disease	Dwarfism	RSPH4A PUS7	1.65e-03	25	71	2	C0013336
Disease	Adenoid Cystic Carcinoma	SOX11 ARID4B FBXW7	1.83e-03	100	71	3	C0010606
Disease	uterine fibroid measurement	SRPK2 PUS7	2.22e-03	29	71	2	EFO_0009410

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDDEEEEGDDEGQKS	ACIN1	281	Q9UKV3
TNKEEDEDDEEAEEE	ARID4B	531	Q4LE39
KEEEEDAEEDQDGDA	PABPN1L	51	A6NDY0
IEDEDEDEFKDEDQD	CCDC116	591	Q8IYX3
EDEFKDEDQDEDKDE	CCDC116	596	Q8IYX3
QLESEEGQEDEDEED	ARMH4	606	Q86TY3
TEEEEEEEEGNEAAN	CT47B1	91	P0C2W7
EEEEEEEEDEESGNQ	EHMT2	316	Q96KQ7
QEGQEDDEEEDEEEE	DAXX	471	Q9UER7
EDLQENDEEGSEDEA	DDX27	156	Q96GQ7
SESDNEDQDEDEEKG	AP3B2	716	Q13367
ETEQQQKEEEEEDED	DENND4A	1176	Q7Z401
EDDIEATGEENKEEE	NAP1L2	221	Q9ULW6
EDEEEEENIDLEKND	IRX5	186	P78411
DQKEERDVEEDNEEE	L3MBTL3	151	Q96JM7
FVQKGEADDEDDDED	PBRM1	151	Q86U86
DDDEEEDEEEEDNKT	MDN1	4781	Q9NU22
GTLEDEDEDEDNDDI	LONP2	256	Q86WA8
GEAEQSEEEADEEDK	MAP1B	1011	P46821
LENDENVEEGNEEED	DPF3	146	Q92784
NVEEGNEEEDLEEDI	DPF3	151	Q92784
NENGEEEEEEAEFGE	LMNB2	586	Q03252
EEEEKEVENEDEDDD	BCCIP	26	Q9P287
EVENEDEDDDDSDKE	BCCIP	31	Q9P287
EGEDQEDKEEDEEEQ	ISM2	281	Q6H9L7
DVAEGEEEEEENEDL	CUL7	1366	Q14999
EEEDQKEDEEDQNEE	HMGN5	126	P82970
DEDDDEPEEDDQEIK	NRDE2	556	Q9H7Z3
DDEIQFDDIGDDDED	EIF1AY	126	O14602
EKNENQENDDEGEED	LRRK2	331	Q5S007
AEDEQENEDDEEERD	POLE	1946	Q07864
GEEEDEDEEEAASQQ	FOXD4	31	Q12950
NDEDEDEDVQVEEAE	NBPF1	166	Q3BBV0
ENDEDEDEDVQVEEA	NBPF1	436	Q3BBV0
QEEDHEDQTDTEGED	PLIN1	291	O60240
ENDDDEDEDVKVEEA	NBPF3	221	Q9H094
DDFVVQDEEGDEENK	CCDC82	296	Q8N4S0
EEDEEEKEQDEDEYK	GPATCH11	221	Q8N954
DQQPQEEEEKDEEGE	KDM2B	416	Q8NHM5
EEQEEDEEHAGEQDE	FBXW7	96	Q969H0
EDAEQEEGKEGSEDE	C17orf50	21	Q8WW18
EEGKEGSEDEDEDNQ	C17orf50	26	Q8WW18
DTGNEEQEEEEDDEE	DDX10	576	Q13206
ECGADDLNEEEEEEE	PROCA1	166	Q8NCQ7
AEQEEVECEENDGEE	PIP4K2A	286	P48426
SDNDDDEGEEEEEEN	UPF2	1061	Q9HAU5
EKDNDVDEEDEEDEL	IRF6	136	O14896
NSIQKNEEEEEEEDE	RSPH4A	561	Q5TD94
NEEEEEEEDEEKDDS	RSPH4A	566	Q5TD94
GEEEAGEEEEEEQDQ	STK11IP	516	Q8N1F8
GEEEEEEQDQKEVEA	STK11IP	521	Q8N1F8
DDDDDDDDELQLQIK	SOX11	226	P35716
NDEDEDEDVQVEEDE	NBPF8	131	Q3BBV2
NDEDEDEDVQVEEDE	NBPF9	166	P0DPF3
NDEDEDEDVQVEEAE	NBPF10	166	Q6P3W6
NDEDEDEDVQVEEDE	NBPF11	166	Q86T75
NDEDEDEDVQVEEDE	NBPF12	166	Q5TAG4
ENDEDEDEDVQVEED	NBPF12	436	Q5TAG4
ASEKQEDVEEEDDDD	PRDM16	1111	Q9HAZ2
DEDQEEETQGQEEGD	RNF167	281	Q9H6Y7
GKNSEAQLEDEEEEE	PUS7	71	Q96PZ0
DELKDSEEFGENEEE	SLTM	121	Q9NWH9
EEEEEEEETSNEGEN	IBSP	76	P21815
EKESDEEEEEEEEGN	IBSP	146	P21815
EEEEEEEEGNENEES	IBSP	151	P21815
EEEGNENEESEAEVD	IBSP	156	P21815
QDESEEEEEGDVEKE	NOM1	256	Q5C9Z4
EDDDEDTEEEQGEEK	NOM1	281	Q5C9Z4
KEEEEDDENEANEGE	WRN	506	Q14191
DDENEANEGEEDDDK	WRN	511	Q14191
NQEEEEEEDKEEEEE	HRC	531	P23327
EDQEENEEDKEEEEK	CCDC136	1076	Q96JN2
KREEDEENDNDNESD	CHRAC1	111	Q9NRG0
KLDNEDGFEEEEEEE	CLSPN	621	Q9HAW4
EEEEKEEEEEEEGNQ	CLSPN	661	Q9HAW4
DDEEEEEENLDDQDE	SUPT6H	36	Q7KZ85
EDEEDQNEEEDEWEE	TRIM52	51	Q96A61
QNEEEDEWEEEEDEE	TRIM52	56	Q96A61
LQDAEEEKDDSNEEE	TMX4	241	Q9H1E5
EGDEEAEEEQEENLE	XRCC6	11	P12956
ESEEEEEEDDNNEGD	PES1	456	O00541
ENEEEEEDAEAGSEK	PES1	476	O00541
LEQQTDGDCEEDEEE	SEC62	371	Q99442
NDGEEAFEDEEEEID	TUBB6	431	Q9BUF5
DNGEAEDQEEKEDAE	SRPK2	341	P78362
EEEEYEQDERDQKEE	YTHDC1	246	Q96MU7
EEEQKEQEEQEEEGA	ZBTB17	231	Q13105
EADEELVDDGEDQND	ZBTB10	841	Q96DT7
DDDDDNDGVTDEKDN	THBS2	741	P35442
GDEEFEEEEEESENK	ZEB2	1156	O60315
EQEADNEVDEEEEEG	PTMA	46	P06454
EEEQQEEGEEDEDDV	VIRMA	241	Q69YN4
VEEEDEDAEGKDEEN	WDR43	636	Q15061
DDEIQFDDIGDDDED	EIF1AX	126	P47813
KDLFNQEDEEEEDDV	AK7	491	Q96M32
EEEEDEGAKSDQAEE	NEFM	536	P07197