Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	eukaryotic translation initiation factor 2 complex	EIF2S3 EIF2S3B	1.99e-04	6	77	2	GO:0005850
GeneOntologyCellularComponent	integrin complex	ITGA2B ITGA5 ITGA7	2.21e-04	32	77	3	GO:0008305
MousePheno	abnormal circulating chemokine level	ASAH1 PGLYRP2 ZFPM1 SLC6A14	1.01e-05	31	62	4	MP:0010209
Domain	GPCR_2_brain_angio_inhib	ADGRB1 ADGRB2 ADGRB3	6.48e-08	3	76	3	IPR008077
Domain	GAIN_dom_N	CELSR3 ADGRB1 ADGRB2 ADGRB3	8.17e-08	11	76	4	IPR032471
Domain	GAIN	CELSR3 ADGRB1 ADGRB2 ADGRB3	8.17e-08	11	76	4	PF16489
Domain	HormR	CELSR3 ADGRB1 ADGRB2 ADGRB3	3.00e-06	25	76	4	SM00008
Domain	GPCR_2_secretin-like	FZD7 CELSR3 ADGRB1 ADGRB2 ADGRB3	4.48e-06	60	76	5	IPR000832
Domain	GPCR_2-like	FZD7 CELSR3 ADGRB1 ADGRB2 ADGRB3	4.48e-06	60	76	5	IPR017981
Domain	HRM	CELSR3 ADGRB1 ADGRB2 ADGRB3	4.81e-06	28	76	4	PF02793
Domain	G_PROTEIN_RECEP_F2_4	FZD7 CELSR3 ADGRB1 ADGRB2 ADGRB3	4.86e-06	61	76	5	PS50261
Domain	Integrin_alpha	ITGA2B ITGA5 ITGA7	1.04e-05	11	76	3	PF00357
Domain	GPS	CELSR3 ADGRB1 ADGRB2 ADGRB3	1.07e-05	34	76	4	SM00303
Domain	GPS	CELSR3 ADGRB1 ADGRB2 ADGRB3	1.20e-05	35	76	4	PF01825
Domain	GPS	CELSR3 ADGRB1 ADGRB2 ADGRB3	1.35e-05	36	76	4	PS50221
Domain	GPS	CELSR3 ADGRB1 ADGRB2 ADGRB3	1.51e-05	37	76	4	IPR000203
Domain	-	AP2A1 AP2A2	1.63e-05	2	76	2	2.60.40.1030
Domain	AP2_complex_asu	AP2A1 AP2A2	1.63e-05	2	76	2	IPR017104
Domain	Clathrin_a-adaptin_app_sub_C	AP2A1 AP2A2	1.63e-05	2	76	2	IPR003164
Domain	Clathrin_a-adaptin_app_Ig-like	AP2A1 AP2A2	1.63e-05	2	76	2	IPR013038
Domain	Alpha_adaptin_C	AP2A1 AP2A2	1.63e-05	2	76	2	PF02296
Domain	G_PROTEIN_RECEP_F2_1	CELSR3 ADGRB1 ADGRB2 ADGRB3	2.07e-05	40	76	4	PS00649
Domain	GPCR_2_extracellular_dom	CELSR3 ADGRB1 ADGRB2 ADGRB3	2.07e-05	40	76	4	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	CELSR3 ADGRB1 ADGRB2 ADGRB3	2.07e-05	40	76	4	PS50227
Domain	Integrin_alpha_C_CS	ITGA2B ITGA5 ITGA7	3.49e-05	16	76	3	IPR018184
Domain	Integrin_alpha-2	ITGA2B ITGA5 ITGA7	5.06e-05	18	76	3	IPR013649
Domain	Integrin_alpha2	ITGA2B ITGA5 ITGA7	5.06e-05	18	76	3	PF08441
Domain	Integrin_alpha	ITGA2B ITGA5 ITGA7	5.06e-05	18	76	3	IPR000413
Domain	INTEGRIN_ALPHA	ITGA2B ITGA5 ITGA7	5.06e-05	18	76	3	PS00242
Domain	G_PROTEIN_RECEP_F2_2	CELSR3 ADGRB1 ADGRB2 ADGRB3	5.06e-05	50	76	4	PS00650
Domain	7tm_2	CELSR3 ADGRB1 ADGRB2 ADGRB3	5.06e-05	50	76	4	PF00002
Domain	Int_alpha_beta-p	ITGA2B ITGA5 ITGA7	5.99e-05	19	76	3	IPR013519
Domain	Int_alpha	ITGA2B ITGA5 ITGA7	5.99e-05	19	76	3	SM00191
Domain	FG_GAP	ITGA2B ITGA5 ITGA7	9.43e-05	22	76	3	PS51470
Domain	-	AP2A1 AP2A2	9.75e-05	4	76	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	AP2A1 AP2A2	9.75e-05	4	76	2	IPR015873
Domain	FG-GAP	ITGA2B ITGA5 ITGA7	1.23e-04	24	76	3	PF01839
Domain	FG-GAP	ITGA2B ITGA5 ITGA7	1.23e-04	24	76	3	IPR013517
Domain	Integrin_dom	ITGA2B ITGA5 ITGA7	1.40e-04	25	76	3	IPR032695
Domain	EGF_LAM_2	CELSR3 USH2A STAB1	2.43e-04	30	76	3	PS50027
Domain	EGF_LAM_1	CELSR3 USH2A STAB1	2.43e-04	30	76	3	PS01248
Domain	Laminin_EGF	CELSR3 USH2A STAB1	3.86e-04	35	76	3	PF00053
Domain	EGF_Lam	CELSR3 USH2A STAB1	3.86e-04	35	76	3	SM00180
Domain	Coatomer/calthrin_app_sub_C	AP2A1 AP2A2	4.50e-04	8	76	2	IPR009028
Domain	Laminin_EGF	CELSR3 USH2A STAB1	4.93e-04	38	76	3	IPR002049
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP2A1 AP2A2	5.77e-04	9	76	2	IPR008152
Domain	Alpha_adaptinC2	AP2A1 AP2A2	5.77e-04	9	76	2	PF02883
Domain	Alpha_adaptinC2	AP2A1 AP2A2	5.77e-04	9	76	2	SM00809
Domain	Coatomer/clathrin_app_Ig-like	AP2A1 AP2A2	1.05e-03	12	76	2	IPR013041
Domain	Clathrin/coatomer_adapt-like_N	AP2A1 AP2A2	1.66e-03	15	76	2	IPR002553
Domain	Adaptin_N	AP2A1 AP2A2	1.66e-03	15	76	2	PF01602
Domain	TSP_1	ADGRB1 ADGRB2 ADGRB3	2.16e-03	63	76	3	PF00090
Domain	TSP1	ADGRB1 ADGRB2 ADGRB3	2.36e-03	65	76	3	SM00209
Domain	TSP1_rpt	ADGRB1 ADGRB2 ADGRB3	2.36e-03	65	76	3	IPR000884
Domain	TSP1	ADGRB1 ADGRB2 ADGRB3	2.36e-03	65	76	3	PS50092
Domain	SUGAR_TRANSPORT_1	SLC2A8 SLC22A23	4.26e-03	24	76	2	PS00216
Domain	IPT	NFKB2 PKHD1	5.37e-03	27	76	2	SM00429
Domain	Sugar_transporter_CS	SLC2A8 SLC22A23	7.49e-03	32	76	2	IPR005829
Domain	IPT	NFKB2 PKHD1	7.49e-03	32	76	2	IPR002909
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY	ITGA2B ARHGAP35 ITGA5 ITGA7	2.82e-06	23	62	4	M47537
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	GALC ASAH1 SMPD4 CTSA	1.42e-05	34	62	4	MM17076
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	GALC ASAH1 SMPD4 CTSA	2.49e-05	39	62	4	M48042
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	GALC ASAH1 SMPD4 CTSA	8.45e-05	53	62	4	MM14647
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	GALC ASAH1 SMPD4 CTSA	1.20e-04	58	62	4	M576
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY	ITGA2B ITGA5 ITGA7	1.35e-04	23	62	3	M47720
Pathway	PID_INTEGRIN_CS_PATHWAY	ITGA2B ITGA5 ITGA7	1.96e-04	26	62	3	M47
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY	ITGA2B ITGA5 ITGA7	1.96e-04	26	62	3	M47719
Pathway	REACTOME_L1CAM_INTERACTIONS	AP2A1 AP2A2 ITGA2B ITGA5	2.24e-04	68	62	4	MM14968
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	ITGA2B ITGA5 ITGA7	2.45e-04	28	62	3	M47655
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY	ITGA2B ITGA5 ITGA7	3.02e-04	30	62	3	M47724
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	ITGA2B ITGA5 ITGA7	3.02e-04	30	62	3	M47718
Pathway	WP_GABA_RECEPTOR_SIGNALING	AP2A1 AP2A2 GABBR1	3.34e-04	31	62	3	M39369
Pathway	REACTOME_NEF_MEDIATED_CD8_DOWN_REGULATION	AP2A1 AP2A2	3.94e-04	7	62	2	M27044
Pathway	KEGG_MEDICUS_REFERENCE_HYDROLYSIS_OF_SPHINGOMYELIN	ASAH1 SMPD4	5.24e-04	8	62	2	M47611
Pathway	KEGG_SPHINGOLIPID_METABOLISM	GALC ASAH1 SMPD4	6.61e-04	39	62	3	M15955
Pathway	REACTOME_NEF_MEDIATED_CD4_DOWN_REGULATION	AP2A1 AP2A2	6.72e-04	9	62	2	M27011
Pathway	REACTOME_RECYCLING_OF_EIF2_GDP	EIF2S3 EIF2S3B	6.72e-04	9	62	2	MM15418
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	GALC ASAH1 SMPD4 CTSA	7.10e-04	92	62	4	MM15086
Pathway	REACTOME_CELLULAR_RESPONSE_TO_MITOCHONDRIAL_STRESS	EIF2S3 EIF2S3B	8.37e-04	10	62	2	MM17234
Pathway	BIOCARTA_EIF_PATHWAY	EIF2S3 EIF2S3B	8.37e-04	10	62	2	MM1394
Pathway	BIOCARTA_EIF2_PATHWAY	EIF2S3 EIF2S3B	8.37e-04	10	62	2	MM1469
Pathway	REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS	IMPDH2 PFAS	1.02e-03	11	62	2	M2071
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2A1 AP2A2	1.02e-03	11	62	2	MM14694
Pathway	REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS	IMPDH2 PFAS	1.02e-03	11	62	2	MM15425
Pathway	WP_GPCRS_NONODORANT	FZD7 CELSR3 ADGRB1 ADGRB2 ADGRB3 GABBR1	1.08e-03	266	62	6	MM15843
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2	AP2A1 AP2A2	1.22e-03	12	62	2	MM15163
Pathway	REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR	EIF2S3 EIF2S3B	1.22e-03	12	62	2	MM14981
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	GALC ASAH1 SMPD4 CTSA	1.25e-03	107	62	4	M14857
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2	AP2A1 AP2A2	1.44e-03	13	62	2	M27415
Pathway	REACTOME_NUCLEOTIDE_BIOSYNTHESIS	IMPDH2 PFAS	1.67e-03	14	62	2	MM15551
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2A1 AP2A2	1.67e-03	14	62	2	M10122
Pathway	REACTOME_NUCLEOTIDE_BIOSYNTHESIS	IMPDH2 PFAS	1.67e-03	14	62	2	M27830
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	AP2A1 AP2A2	1.67e-03	14	62	2	MM15161
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	AP2A1 AP2A2	1.93e-03	15	62	2	M27413
Pathway	REACTOME_L1CAM_INTERACTIONS	AP2A1 AP2A2 ITGA2B ITGA5	1.96e-03	121	62	4	M872
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	AP2A1 AP2A2	2.20e-03	16	62	2	M27761
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	AP2A1 AP2A2	2.20e-03	16	62	2	MM15048
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	AP2A1 AP2A2	2.20e-03	16	62	2	MM15506
Pubmed	Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).	ADGRB1 ADGRB2 ADGRB3	1.13e-08	3	79	3	9533023
Pubmed	Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.	ADGRB1 ADGRB2 ADGRB3	1.13e-08	3	79	3	15225653
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	CELSR3 ADGRB1 ADGRB2 ADGRB3	5.61e-07	29	79	4	15203201
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	CELSR3 ADGRB1 ADGRB2 ADGRB3	9.59e-07	33	79	4	25713288
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FZD7 CELSR3 AP2A1 CTC1 NFKB2 ZBTB4 ADGRB2 SLCO4A1 PFAS ZFPM1 ARHGAP35 ITGA5 EVI5L	1.19e-06	1105	79	13	35748872
Pubmed	Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.	SOX1 MNX1 NKX2-2	5.03e-06	15	79	3	15893981
Pubmed	Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.	ADGRB2 ADGRB3	5.09e-06	2	79	2	12218411
Pubmed	Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).	AP2A1 AP2A2	5.09e-06	2	79	2	2564002
Pubmed	Identification of residues of functional importance within the central turn motifs present in the cytoplasmic tails of integrin alphaIIb and alphaV subunits.	ITGA2B ITGA5	5.09e-06	2	79	2	18328539
Pubmed	Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.	AP2A1 AP2A2	5.09e-06	2	79	2	12036598
Pubmed	Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.	EIF2S3 EIF2S3B	5.09e-06	2	79	2	16325480
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	CELSR3 AP2A1 AP2A2	6.18e-06	16	79	3	24305805
Pubmed	IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses.	ITGA2B ITGA5 ITGA7	1.25e-05	20	79	3	22687584
Pubmed	T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration.	FZD7 CELSR3 MNX1	1.46e-05	21	79	3	17119020
Pubmed	Roles for GP IIb/IIIa and αvβ3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction.	ITGA2B ITGA5	1.53e-05	3	79	2	24176823
Pubmed	Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.	AP2A1 AP2A2	1.53e-05	3	79	2	35014951
Pubmed	A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.	AP2A1 AP2A2	1.53e-05	3	79	2	18032517
Pubmed	AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.	AP2A1 AP2A2	1.53e-05	3	79	2	22262466
Pubmed	Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.	AP2A1 AP2A2	1.53e-05	3	79	2	26269175
Pubmed	A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.	AP2A1 AP2A2	1.53e-05	3	79	2	19129443
Pubmed	Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging.	SOX1 NKX2-2	1.53e-05	3	79	2	39251590
Pubmed	Interaction of Shc with adaptor protein adaptins.	AP2A1 AP2A2	1.53e-05	3	79	2	8617812
Pubmed	Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein.	ITGA2B ITGA5	1.53e-05	3	79	2	10358085
Pubmed	Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt signaling pathway.	ITGA5 ABHD11	1.53e-05	3	79	2	34375304
Pubmed	The muscle-specific laminin receptor alpha7 beta1 integrin negatively regulates alpha5 beta1 fibronectin receptor function.	ITGA5 ITGA7	1.53e-05	3	79	2	9925758
Pubmed	The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.	AP2A1 AP2A2	1.53e-05	3	79	2	8662627
Pubmed	Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD.	SOX1 USH2A	1.53e-05	3	79	2	25234806
Pubmed	Motor neurons with axial muscle projections specified by Wnt4/5 signaling.	FZD7 MNX1 NKX2-2	1.68e-05	22	79	3	19285468
Pubmed	Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.	ITGA2B ITGA5 ITGA7	1.93e-05	23	79	3	23152823
Pubmed	Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation.	ITGA2B ITGA5	3.05e-05	4	79	2	20052668
Pubmed	The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.	AP2A1 AP2A2	3.05e-05	4	79	2	12646615
Pubmed	Calcium Integrin Binding Protein Associates with Integrins αVβ3 and αIIbβ3 Independent of β3 Activation Motifs.	ITGA2B ITGA5	3.05e-05	4	79	2	24163826
Pubmed	Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.	AP2A1 AP2A2	3.05e-05	4	79	2	20500056
Pubmed	Placental defects in alpha7 integrin null mice.	ITGA5 ITGA7	3.05e-05	4	79	2	17904217
Pubmed	Identification of a novel binding site for platelet integrins alpha IIb beta 3 (GPIIbIIIa) and alpha 5 beta 1 in the gamma C-domain of fibrinogen.	ITGA2B ITGA5	3.05e-05	4	79	2	12799374
Pubmed	Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.	EIF2S3 EIF2S3B	3.05e-05	4	79	2	31836389
Pubmed	Association and colocalization of Eps15 with adaptor protein-2 and clathrin.	AP2A1 AP2A2	3.05e-05	4	79	2	9049247
Pubmed	p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.	ARHGAP35 ITGA5	3.05e-05	4	79	2	18541700
Pubmed	Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.	ADGRB2 ADGRB3	3.05e-05	4	79	2	25611509
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA2B ITGA5 ITGA7	3.17e-05	27	79	3	31541017
Pubmed	Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.	SOX1 MNX1 NKX2-2	3.55e-05	28	79	3	24995796
Pubmed	Pax6 is misexpressed in Sox1 null lens fiber cells.	SOX1 ITGA5	5.07e-05	5	79	2	17306631
Pubmed	Weak Molecular Interactions in Clathrin-Mediated Endocytosis.	AP2A1 AP2A2	5.07e-05	5	79	2	29184887
Pubmed	A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.	AP2A1 AP2A2	5.07e-05	5	79	2	17108326
Pubmed	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.	AP2A1 AP2A2	5.07e-05	5	79	2	9723620
Pubmed	A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.	MNX1 NKX2-2	5.07e-05	5	79	2	25340710
Pubmed	Basic amino-acid side chains regulate transmembrane integrin signalling.	ITGA2B ITGA5	5.07e-05	5	79	2	22178926
Pubmed	Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.	AP2A1 AP2A2	5.07e-05	5	79	2	16139856
Pubmed	Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.	AP2A1 AP2A2	5.07e-05	5	79	2	31671891
Pubmed	Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis.	AP2A1 AP2A2	5.07e-05	5	79	2	15941406
Pubmed	Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.	AP2A2 SLC2A8	5.07e-05	5	79	2	16723738
Pubmed	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.	SOX1 MNX1 NKX2-2	5.34e-05	32	79	3	19286674
Pubmed	Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.	SOX1 MNX1 NKX2-2	5.86e-05	33	79	3	25179941
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	SOX1 NUP37 NKX2-2	6.42e-05	34	79	3	18539113
Pubmed	FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism.	SOX1 MNX1 NKX2-2	6.42e-05	34	79	3	18590716
Pubmed	Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.	AP2A1 AP2A2	7.60e-05	6	79	2	22650988
Pubmed	Integrins take partners: cross-talk between integrins and other membrane receptors.	ITGA2B ITGA5	7.60e-05	6	79	2	9789327
Pubmed	Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.	AP2A1 AP2A2	7.60e-05	6	79	2	22713487
Pubmed	Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development.	ITGA5 ITGA7	7.60e-05	6	79	2	9686317
Pubmed	Role for the alpha7beta1 integrin in vascular development and integrity.	ITGA5 ITGA7	7.60e-05	6	79	2	16003770
Pubmed	Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin.	GAK AP2A2	7.60e-05	6	79	2	12732633
Pubmed	Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.	ITGA2B ITGA7	7.60e-05	6	79	2	22779914
Pubmed	The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.	AP2A1 AP2A2	7.60e-05	6	79	2	12121421
Pubmed	Clathrin.	AP2A1 AP2A2	7.60e-05	6	79	2	10966473
Pubmed	Molecular architecture and functional model of the endocytic AP2 complex.	AP2A1 AP2A2	7.60e-05	6	79	2	12086608
Pubmed	HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.	AP2A1 AP2A2	7.60e-05	6	79	2	15020715
Pubmed	Functional interaction of CD154 protein with α5β1 integrin is totally independent from its binding to αIIbβ3 integrin and CD40 molecules.	ITGA2B ITGA5	7.60e-05	6	79	2	22461623
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	GAK UTP18 DYM IMPDH2 AP2A2 EIF2S3 NFKB2 CIAO2B SMPD4 CTSA EVI5L PML	9.53e-05	1440	79	12	30833792
Pubmed	Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.	AP2A1 AP2A2	1.06e-04	7	79	2	20351096
Pubmed	Clathrin interacts specifically with amphiphysin and is displaced by dynamin.	AP2A1 AP2A2	1.06e-04	7	79	2	9280305
Pubmed	Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior.	ARHGAP35 ITGA5	1.06e-04	7	79	2	23595732
Pubmed	Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.	AP2A1 AP2A2	1.06e-04	7	79	2	7671305
Pubmed	Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.	MNX1 NKX2-2	1.06e-04	7	79	2	24411943
Pubmed	Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.	ITGA2B ITGA5	1.06e-04	7	79	2	12042322
Pubmed	Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks.	MNX1 NKX2-2	1.06e-04	7	79	2	33547135
Pubmed	Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.	AP2A1 AP2A2	1.06e-04	7	79	2	16103193
Pubmed	Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.	EIF2S3 EIF2S3B	1.06e-04	7	79	2	15669143
Pubmed	Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.	AP2A1 AP2A2	1.06e-04	7	79	2	23676497
Pubmed	The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand.	ITGA2B ITGA5	1.06e-04	7	79	2	37184585
Pubmed	Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch.	MNX1 NKX2-2	1.41e-04	8	79	2	21382552
Pubmed	Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.	AP2A1 AP2A2	1.41e-04	8	79	2	2014052
Pubmed	Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.	AP2A1 AP2A2	1.41e-04	8	79	2	11879655
Pubmed	Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse.	MNX1 NKX2-2	1.41e-04	8	79	2	30301781
Pubmed	Developmental regulation of integrin expression at the time of implantation in the mouse embryo.	ITGA5 ITGA7	1.41e-04	8	79	2	8306881
Pubmed	ARL13B regulates Sonic hedgehog signaling from outside primary cilia.	MNX1 NKX2-2	1.41e-04	8	79	2	32129762
Pubmed	Accessory protein recruitment motifs in clathrin-mediated endocytosis.	AP2A1 AP2A2	1.82e-04	9	79	2	12057195
Pubmed	Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.	MNX1 NKX2-2	1.82e-04	9	79	2	29389974
Pubmed	A Cre transgenic line for studying V2 neuronal lineages and functions in the spinal cord.	SOX1 NKX2-2	1.82e-04	9	79	2	20806357
Pubmed	Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution.	EIF2S3 EIF2S3B	1.82e-04	9	79	2	9736774
Pubmed	Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system.	MNX1 NKX2-2	1.82e-04	9	79	2	25840610
Pubmed	Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program.	SOX1 TBR1	1.82e-04	9	79	2	29530878
Pubmed	Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system.	AP2A1 AP2A2	1.82e-04	9	79	2	11591131
Pubmed	Species-specific pace of development is associated with differences in protein stability.	MNX1 NKX2-2	1.82e-04	9	79	2	32943498
Pubmed	Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice.	EIF2S3 EIF2S3B	1.82e-04	9	79	2	17873295
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	FZD7 SLC2A8 ADGRB1 SLCO4A1 STARD3NL ITGA5 CTSA GABBR1	1.87e-04	697	79	8	28298427
Pubmed	Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis.	SOX1 NKX2-2	2.27e-04	10	79	2	31249377
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	AP2A1 AP2A2	2.27e-04	10	79	2	25898166
Pubmed	HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.	AP2A1 AP2A2	2.27e-04	10	79	2	17581864
Pubmed	Coordination of progenitor specification and growth in mouse and chick spinal cord.	SOX1 NKX2-2	2.27e-04	10	79	2	25258086
Pubmed	Nkx2.2 and Nkx2.9 are the key regulators to determine cell fate of branchial and visceral motor neurons in caudal hindbrain.	MNX1 NKX2-2	2.27e-04	10	79	2	25919494
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	CTC1 ZBTB4 PFAS OVCA2 CHRNE	3.37e-04	346	79	5	chr17p13
Cytoband	6p25.2	SLC22A23 NQO2	6.60e-04	22	79	2	6p25.2
Cytoband	17p13.1	CTC1 ZBTB4 PFAS	1.14e-03	118	79	3	17p13.1
GeneFamily	Adhesion G protein-coupled receptors, subfamily B	ADGRB1 ADGRB2 ADGRB3	2.11e-08	3	51	3	912
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA2B ITGA5 ITGA7	1.67e-05	18	51	3	1160
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4B FNIP1	2.25e-03	25	51	2	504
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	GAK DNAJC11	8.43e-03	49	51	2	584
Coexpression	GSE30153_LUPUS_VS_HEALTHY_DONOR_BCELL_DN	FZD7 TAF1C ADGRB3 CTSA CHRNE STAB1	2.82e-05	198	78	6	M8424
Coexpression	GSE5679_PPARG_LIGAND_ROSIGLITAZONE_VS_RARA_AGONIST_AM580_TREATED_DC_DN	CCDC87 PGLYRP2 ITGA7 CTSA NCKAP5L MEX3B	2.98e-05	200	78	6	M6563
Coexpression	GSE5455_EX_VIVO_VS_POST_24H_INCUBATION_MONOCYTES_FROM_TUMOR_BEARING_MOUSE_DN	PGLYRP2 ITGA7 CTSA NCKAP5L MEX3B FAM98C	2.98e-05	200	78	6	M6580
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MNX1 MMP28 PGLYRP2 ZFPM1 ITGA7	1.20e-05	167	79	5	7f3224af9b30082b927a822b91f96e0c88151b4e
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MNX1 MMP28 PGLYRP2 ZFPM1 ITGA7	1.20e-05	167	79	5	a21a2b301d0a3d7a41e605f7a3c37548962a331d
ToppCell	facs-Brain_Myeloid-Hippocampus-24m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MNX1 MMP28 PGLYRP2 ZFPM1 ITGA7	1.20e-05	167	79	5	0e746483773bde6582874a33591ab2a578d724eb
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MNX1 MMP28 PGLYRP2 ZFPM1 ITGA7	1.31e-05	170	79	5	b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSC1 TM4SF4 ADGRB3 PKHD1 USH2A	1.50e-05	175	79	5	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX1 CCDC87 ADGRB2 ADGRB3 TBR1	2.01e-05	186	79	5	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOX1 FZD7 ADGRB1 ADGRB2 ITGA7	2.46e-05	194	79	5	68d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DYM ITGA2B CTSA EVI5L STAB1	2.85e-05	200	79	5	326cae37cacd94b423a6ac8873ea56c5abaf0a0b
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NFKB2 SLCO4A1 ITGA5 PML SEC14L1	2.85e-05	200	79	5	16a70cc07dcfb4eba4385b712f27010c6629ff67
Disease	MEHMO syndrome (implicated_via_orthology)	EIF2S3 EIF2S3B	6.90e-06	2	78	2	DOID:0060801 (implicated_via_orthology)
Disease	hypopituitarism (implicated_via_orthology)	EIF2S3 EIF2S3B	1.03e-04	6	78	2	DOID:9406 (implicated_via_orthology)
Disease	leukodystrophy (implicated_via_orthology)	EIF2S3 EIF2S3B	2.45e-04	9	78	2	DOID:10579 (implicated_via_orthology)
Disease	Cholecystitis	CYP7A1 TM4SF4	1.15e-03	19	78	2	HP_0001082
Disease	Neonatal diabetes mellitus	MNX1 NKX2-2	1.99e-03	25	78	2	C0158981
Disease	glucose metabolism disease (implicated_via_orthology)	EIF2S3 EIF2S3B	2.49e-03	28	78	2	DOID:4194 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLEGGLLYAFVGPAA	ADGRB2	1071	O60241
GVGVGAALQDALYPL	EVI5L	741	Q96CN4
GLRFYAFNPLAGGLL	AKR7A3	191	O95154
LNEPAGLYELDGQLG	CTC1	366	Q2NKJ3
SLEGGLLYAFVGPAA	ADGRB1	1086	O14514
SLEGGLLYAFVGPAA	ADGRB3	1016	O60242
YLGPTLFLLGGNSQF	ABHD11	256	Q8NFV4
GYILGEFGNLIAGDP	AP2A1	501	O95782
LAPAYFILGGNQSGE	ASAH1	276	Q13510
GAGALYNHLAGELDP	CCDC87	461	Q9NVE4
GLVLLAYFLPAQAGG	CHRNE	256	Q04844
YILGEFGNLIAGDPR	AP2A2	501	O94973
GGGLGSLLYDFLLFP	MIP	211	P30301
GAAGGFALYPLLNEA	CDC42BPG	1241	Q6DT37
AFNGPKGGYVALDDI	MAMDC2	306	Q7Z304
PGLALQDAQDLYAAG	ANXA8	176	P13928
LEFGAGDLQGPLFGL	DNAJC11	211	Q9NVH1
ESYLQAFLAGAAGPL	NCKAP5L	336	Q9HCH0
LAAVFPLGLDGYHIG	GABBR1	641	Q9UBS5
AQGGAGLPAQAALYG	MNX1	146	P50219
CGDGLTYNDFLILPG	IMPDH2	26	P12268
AFLNGALDGVILGDY	PGLYRP2	271	Q96PD5
YAGLLAAAAAGLGSP	ERFE	16	Q4G0M1
GELGLAGALFLPQYV	ZFPM1	516	Q8IX07
AGLPEGLLDGAQDAY	FOXO6	316	A8MYZ6
AYAASGGVLGLNLQP	GHDC	291	Q8N2G8
PFENGDSGNLIAYGG	NUP37	26	Q8NFH4
AFDIPGFYDSGLLQG	NQO2	126	P16083
TGGLGLNLALNPFEY	SMPD4	181	Q9NXE4
FYPGLGLALAFHDGS	MED16	376	Q9Y2X0
GLNIYNLYAPCAGGV	CTSA	271	P10619
LDGNGYPDLIVGSFG	ITGA5	466	P08648
ALLGALSAGAGAQPY	FZD7	21	O75084
GLALAEYDQPYGGFL	GAK	361	O14976
YGARALNEGGFQSIP	ETFDH	361	Q16134
FPQQSDGGGLLYGLA	DYM	236	Q7RTS9
PNIANFGRSLLGGYC	FNIP1	991	Q8TF40
SGGAYLFLLLDGAGD	LINC02875	121	Q86X59
DYFVVAGLAGNGAPI	DENND4B	11	O75064
QDGFPAGQELLGYKA	DSC1	481	Q08554
QDLLALGYGGVPGAA	FAM98C	16	Q17RN3
NGLIPYLGCALQFGA	CYP7A1	36	P22680
GPAGDLALNSYLGFS	ITGA7	296	Q13683
NDLQYAAPGGLIGVG	EIF2S3B	326	Q2VIR3
LLGLAVGLDPEGYGN	CELSR3	2656	Q9NYQ7
GLGPGAYNNTALFEE	CELSR3	2801	Q9NYQ7
LLAPGGAYVLDDSDG	GALC	36	P54803
LIYAGNDYQGPGGLL	SEC14L1	461	Q92503
GVGGGLLENANPLIY	CIAO2B	6	Q9Y3D0
PLAQYLAAAGVGRLG	MOCS3	96	O95396
IDAYGDFLQALGPGA	FPGT	311	O14772
NAFDGPGGALAHAFL	MMP28	196	Q9H239
YAAYANGLGAQLPGL	MEX3B	471	Q6ZN04
GAQFLGAGFLELHPY	USH2A	1716	O75445
PDGSFLLINGIAGYL	UTP18	351	Q9Y5J1
AGANPYLGEEAEGLA	TBR1	576	Q16650
LLLDYDGSVLPFLGG	SLC22A23	76	A1A5C7
FGQLVYPAGGAQDRL	TAF1C	226	Q15572
LGTYFEGLLEGPALA	PML	846	P29590
FAAALGPLSFGFALG	SLC2A8	31	Q9NY64
EGLQYSLHGLAAGAP	NKX2-2	81	O95096
IFDGLELGVLYPNNG	PKHD1	41	P08F94
ELVLGAPGGYYFLGL	ITGA2B	211	P08514
LPYGAAAAAAAAAGG	SOX1	276	O00570
PFDGLLGFSQGAALA	OVCA2	111	Q8WZ82
VFLDPASAGIGYGRN	ARHGAP35	731	Q9NRY4
PAAGYLIGGALLNIY	SLCO4A1	276	Q96BD0
LPFLGAGVQLQDNGY	CLCA2	26	Q9UQC9
APADAGLGALRGDGY	TCF24	111	Q7RTU0
GRLSLAAAAGDPFAY	SRCIN1	406	Q9C0H9
AALIPGGLSDGQFYS	STARD3NL	196	O95772
DYGNKFGEPVLAGFA	PFAS	391	O15067
NFIYSARLALPGGGG	ZBTB4	141	Q9P1Z0
PFEGGLAYGIDQLLE	STAB1	1851	Q9NY15
GSLAGLGAYQLYQDP	TMEM14B	46	Q9NUH8
DGGAPTFLSYNALDG	TRAV1-1	56	A0A0B4J248
AFIAYPEALAQLPGG	SLC6A14	391	Q9UN76
GGTLIPLAFFGFLAN	TM4SF4	11	P48230
NDLQYAAPGGLIGVG	EIF2S3	326	P41091
FAGNTPLHLAAGLGY	NFKB2	666	Q00653