Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	AMP-bd_C	ACSF2 ACSS3	1.47e-03	17	63	2	IPR025110
Domain	AMP-binding_C	ACSF2 ACSS3	1.47e-03	17	63	2	PF13193
Domain	AMP-binding_CS	ACSF2 ACSS3	3.45e-03	26	63	2	IPR020845
Domain	AMP_BINDING	ACSF2 ACSS3	4.00e-03	28	63	2	PS00455
Domain	hEGF	JAG2 FBN3	4.00e-03	28	63	2	PF12661
Domain	AMP-binding	ACSF2 ACSS3	4.58e-03	30	63	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSF2 ACSS3	4.58e-03	30	63	2	IPR000873
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	C2orf69 ADO CLPB MTG2 NADK2 C8orf82 ACAA2 ACSF2 NDUFB2 MMAB NT5DC3 LACTB ACSS3	2.67e-07	1136	68	13	34800366
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAG2 ZNF276 ADAMTSL5 ZFP36L2 MTG2 LAMA5 EML2 IL17RD FBXO46 AHDC1 SAP30 CABLES1	1.41e-06	1105	68	12	35748872
Pubmed	Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation.	TBX18 TCF15 NKX3-2	3.93e-06	16	68	3	17477400
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	ADO CLPB MTG2 C8orf82 ACAA2 ACSF2 NDUFB2 MMAB NT5DC3 LACTB ACSS3	5.58e-06	1047	68	11	18614015
Pubmed	Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.	ACAA2 HMGCR MMAB	2.52e-05	29	68	3	20972250
Pubmed	Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development.	JAG2 KRT17	7.86e-05	7	68	2	25104574
Pubmed	Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity.	TBX18 TCF15	1.05e-04	8	68	2	26718008
Pubmed	Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis.	TBX18 TCF15	1.05e-04	8	68	2	15469977
Pubmed	Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.	SHANK1 DLGAP3	1.05e-04	8	68	2	19640847
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	IL17RD EN2	1.34e-04	9	68	2	15872005
Pubmed	Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.	JAG2 KRT17	1.68e-04	10	68	2	19439425
Pubmed	Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.	ACSF2 ACSS3	1.68e-04	10	68	2	17762044
Pubmed	Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.	JAG2 KRT17	2.05e-04	11	68	2	16607638
Pubmed	IRF6 expression in basal epithelium partially rescues Irf6 knockout mice.	JAG2 KRT17	2.05e-04	11	68	2	28643456
Pubmed	Genome-wide and candidate gene association study of cigarette smoking behaviors.	CHRNA5 CABLES1	2.90e-04	13	68	2	19247474
Pubmed	An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.	EN2 OGA	3.38e-04	14	68	2	23453598
Pubmed	The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5.	NKX3-2 EN2	3.38e-04	14	68	2	9271679
Pubmed	Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.	CLPB WHAMM ACAA2	3.71e-04	71	68	3	33499712
Pubmed	Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis.	TBX18 TCF15	3.89e-04	15	68	2	23671110
Pubmed	Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.	TBX18 NKX3-2	3.89e-04	15	68	2	19520072
Pubmed	Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.	JAG2 EN2	3.89e-04	15	68	2	12167404
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	MCIDAS CHAF1A OGA FBXO46 AHDC1 SAP30	4.19e-04	495	68	6	27705803
Pubmed	Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.	ACAA2 HMGCR MMAB	4.36e-04	75	68	3	20571754
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	ADO CLPB MTG2 ACAA2 ACSF2 NDUFB2 MMAB LACTB	4.42e-04	926	68	8	20877624
Pubmed	Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.	TBX18 NKX3-2	4.44e-04	16	68	2	27381226
Pubmed	Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.	TBX18 TCF15	5.03e-04	17	68	2	18045842
Pubmed	The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments.	TBX18 TCF15	5.03e-04	17	68	2	15155583
Pubmed	Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.	TBX18 TCF15	5.65e-04	18	68	2	17490632
Pubmed	Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning.	TBX18 TCF15	5.65e-04	18	68	2	16387292
Pubmed	An integrated genetic map of the pearl locus of mouse chromosome 13.	GZMA HMGCR	6.30e-04	19	68	2	8828042
Pubmed	The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.	TBX18 TCF15	6.30e-04	19	68	2	11562355
Pubmed	Cooperative activity of noggin and gremlin 1 in axial skeleton development.	TBX18 NKX3-2	6.30e-04	19	68	2	21303853
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	TBX18 ZBTB45 ZNF276 ATOH7 NKX3-2 EN2	6.86e-04	544	68	6	28473536
Pubmed	Multiple roles of lymphatic vessels in peripheral lymph node development.	LAMA5 SIGLEC1	7.00e-04	20	68	2	30355615
Pubmed	Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.	NADK2 C8orf82 ACAA2 MMAB	7.37e-04	207	68	4	31056398
Pubmed	Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome.	TBX18 TCF15	7.72e-04	21	68	2	14745966
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	CLPB NADK2 OGA LACTB	8.05e-04	212	68	4	33462405
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	EML2 NDUFB2 OGA NT5DC3 FBXO46 AHDC1 RPS6KL1 SPRN	8.36e-04	1021	68	8	26760575
Pubmed	Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.	JAG2 NKX3-2	8.48e-04	22	68	2	21750033
Pubmed	Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.	JAG2 ATOH7	9.28e-04	23	68	2	19191219
Pubmed	Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.	JAG2 LAMA5	9.28e-04	23	68	2	29981310
Pubmed	p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.	JAG2 KRT17	1.01e-03	24	68	2	28604778
Pubmed	Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.	JAG2 ATOH7	1.28e-03	27	68	2	24148613
Pubmed	Proteomic profiling of Myc-associated proteins.	XDH SDK1 PDZD2	1.47e-03	114	68	3	21150319
Pubmed	Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.	TBX18 NKX3-2	1.58e-03	30	68	2	26057579
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	NADK2 C8orf82 ACAA2 MMAB NT5DC3	1.68e-03	438	68	5	32628020
Pubmed	A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.	NKX3-2 EN2	1.91e-03	33	68	2	10843805
Pubmed	Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.	ACAA2 HMGCR	1.91e-03	33	68	2	18193044
Cytoband	10q21.3	ADO ATOH7	1.18e-03	34	68	2	10q21.3
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	JAG2 LAMA5 CSMD1 RPS6KL1 FBN3 PDZD2	4.27e-06	166	67	6	M39026
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAG2 KRT17 ARHGAP23 LAMA5 CSMD1 SDK1	6.05e-07	199	68	6	94a7867e800df352731796de8c24cba133c29622
ToppCell	Basal_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	JAG2 KRT17 ADAMTSL5 ARHGAP23 NT5DC3	5.56e-06	166	68	5	aea2ae12e4746149ebc6da063ef694381c098f80
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 GPR25 ZFP36L2 RPS6KL1 SAP30	6.80e-06	173	68	5	5d7c53c6d1cdd385e44b79b82faec901747d1736
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 GPR25 ZFP36L2 RPS6KL1 SAP30	6.99e-06	174	68	5	9eab43885496b8586f8ec5b4bcb1fd5b209218e5
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAG2 KRT17 ARHGAP23 LAMA5 SDK1	1.31e-05	198	68	5	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
Drug	AC1NOWCG	ADO XDH EN2 MMAB	2.31e-06	32	67	4	CID005120109
Disease	autosomal recessive limb-girdle muscular dystrophy (is_implicated_in)	JAG2 HMGCR	4.47e-05	5	63	2	DOID:0110274 (is_implicated_in)
Disease	anxiety disorder, stress-related disorder	TUSC1 SDK1	2.92e-04	12	63	2	EFO_0006788, EFO_0010098
Disease	cortical surface area measurement	JAG2 KRT17 CHAF1A C8orf82 EML2 HMGCR IL17RD RPS6KL1 FBN3 PDZD2	5.28e-04	1345	63	10	EFO_0010736
Disease	anxiety	CSMD1 MMAB FBXO46 RPS6KL1	1.33e-03	223	63	4	EFO_0005230
Disease	macular telangiectasia type 2	SLC1A4 FBN3	1.41e-03	26	63	2	EFO_1002009
Disease	pursuit maintenance gain measurement	NPTX2 TCF15 CSMD1	2.34e-03	123	63	3	EFO_0008433
Disease	complex trait	ADO ACAA2 HMGCR CABLES1	2.71e-03	271	63	4	EFO_0010578
Disease	sleep latency	TCF15 CSMD1	2.85e-03	37	63	2	EFO_0005280
Disease	Sclerocystic Ovaries	TCF15 ARHGAP23 DACT3	3.65e-03	144	63	3	C1136382
Disease	Polycystic Ovary Syndrome	TCF15 ARHGAP23 DACT3	3.65e-03	144	63	3	C0032460
Disease	ejection fraction measurement	TUSC1 SLC1A4	3.83e-03	43	63	2	EFO_0005527
Disease	cognitive impairment measurement	CSMD1 FBN3	4.01e-03	44	63	2	EFO_0007998
Disease	Anxiety States, Neurotic	SHANK1 CHRNA5	4.01e-03	44	63	2	C0376280
Disease	Anxiety Disorders	SHANK1 CHRNA5	4.01e-03	44	63	2	C0003469
Disease	Anxiety neurosis (finding)	SHANK1 CHRNA5	4.01e-03	44	63	2	C1279420

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRGARACSGDGGVSY	C8orf82	16	Q6P1X6
FCRAEGACGGTLRGT	CSMD1	201	Q96PZ7
GGSGGARCSLSAEVR	C2orf69	36	Q8N8R5
QACLTFRGSGGGRGA	ADO	16	Q96SZ5
CVRSGRAGTGGAGSK	AFDN-DT	11	Q9Y6Z5
VCAGSLRGGRDSCNG	GZMA	196	P12544
ARALDGACGRTGRLA	GPR25	316	O00155
GRLCAGSSGVLGARA	ACSF2	11	Q96CM8
GGRGGGHAAKSARCS	AHDC1	676	Q5TGY3
GGAGRRGDSQECSPR	CHAF1A	191	Q13111
FSVLFGGRCAGDLAG	FBN3	296	Q75N90
AAGGSGRARGADTCG	IL17RD	26	Q8NFM7
GFLLGSCCRVAGGRA	NADK2	6	Q4G0N4
SCCRVAGGRAAALRG	NADK2	11	Q4G0N4
TNRGCRAIGLGGGAS	HMGCR	566	P04035
SGACCDGDGRTTRAG	JAG2	46	Q9Y219
RGGLASCSVGANGKR	LINC02872	41	A2RU37
RAAAPGGLASSCGRR	LACTB	11	P83111
KGVGSERRSGGGDCS	FBXO46	211	Q6PJ61
GLGFSIAGGRDCIRG	PDZD2	596	O15018
SCGDNSRGQLGRRGA	HERC6	46	Q8IVU3
GAARAREEAGGGFSL	LAMA5	31	O15230
RCLSAGCDGLLGSGA	ADAMTSL5	171	Q6ZMM2
MQACGGGAAGRRAFD	MCIDAS	1	D6RGH6
RCADARGASGAGLAG	NKX3-2	106	P78367
AGRCGLAGAAGGAQR	CHRNA5	21	P30532
LSGGLGAGSCRLGSA	KRT17	31	Q04695
GCAGSDSECSAGRLG	DACT3	516	Q96B18
PGAGGACGARTRFSL	CABLES1	96	Q8TDN4
FKGRSGGSEGRCLAC	DLGAP3	301	O95886
AGTCAGAGRLESAAR	ATOH7	26	Q8N100
GGRQGGRFDTKCLAA	CLPB	71	Q9H078
CALRDGTLVSGGGRD	EML2	301	O95834
RRKDAGTCCAGAGGG	EN2	81	P19622
DTAGAGRCGGRRAAK	SDK1	61	Q7Z5N4
AAGAFAGRRAACGAV	SLC15A4	26	Q8N697
DLRAGFKAGGRDCGT	LRRC40	11	Q9H9A6
GLGSRLGLRGCFGAA	MMAB	11	Q96EY8
GSACNSGISGGRGRK	PRAC1	41	Q96KF2
FGSGEARGCRAAADG	RUSF1	16	Q96GQ5
EDGERCGRAAGNASF	SAP30	71	O75446
AGAAGGARRFLCGVV	OGA	51	O60502
RAATAAALRGGCGTA	NT5DC3	16	Q86UY8
AGSALLRGGAACGRL	SFT2D3	121	Q587I9
GDSHRRGFCSADSGG	PRSS57	206	Q6UWY2
GAGVSCRGGCGFSRL	RNF128	6	Q8TEB7
RRVLVCGGNGGAGAS	MTG2	76	Q9H4K7
RYLGAAADGCGGATV	WHAMM	151	Q8TF30
LARCEGLAGGKARGA	NPTX2	91	P47972
GAGTDGLLALRACSG	SHANK1	1791	Q9Y566
LGGRGCRALSSGSGS	ACSS3	46	Q9H6R3
RRGGKYAVGSACIGG	ACAA2	371	P42765
SSGGRGECDISGAGR	PLPPR4	6	Q7Z2D5
NQRKGGGRRDLGGSC	TCF15	171	Q12870
SGAGRDFLRGAGSAE	ZBTB45	266	Q96K62
AFLCDSGAAKGGRGG	SPRN	16	Q5BIV9
GAASLDASCLGRLGG	SLC1A4	101	P43007
ARSGADLERGAAGGC	TBX18	86	O95935
CSGASGRRAGAGDEA	ARHGAP23	1261	Q9P227
RLAFSALGGGECGES	SOGA1	256	O94964
GCARTAGDGGVRHAG	NDUFB2	21	O95178
RQCGASDGGGGVSRT	ZNF276	16	Q8N554
RTFARDGGCCGGDGN	XDH	161	P47989
SCLSADGAGRGCGRA	RPS6KL1	366	Q9Y6S9
AAGAGAGRRGLLLCR	SIGLEC1	611	Q9BZZ2
CSASGIRAGGEAGRG	ZSWIM8	1441	A7E2V4
GGSARDGSALRCGEC	ZNF746	501	Q6NUN9
SGGASGDLRAFGTRD	ZFP36L2	226	P47974
ATRRGSCCGGDGAAD	TUSC1	11	Q2TAM9
EGLCASRLAVGRGLG	NEXN-AS1	201	Q8NBZ9