Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.44e-06	5	106	3	GO:0030156
GeneOntologyMolecularFunction	structural molecule activity	COL17A1 KRT27 KRT81 KRT28 KRT83 KRT86 OBSCN ACTN3 NEFL LMNB1 PLEC CROCC PLS3 KRT38 KRT37	7.18e-05	891	106	15	GO:0005198
GeneOntologyBiologicalProcess	intermediate filament organization	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL PLEC KRT38 KRT37	1.83e-10	75	107	9	GO:0045109
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL PLEC KRT38 KRT37	2.27e-09	99	107	9	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL PLEC KRT38 KRT37	2.48e-09	100	107	9	GO:0045103
GeneOntologyBiologicalProcess	supramolecular fiber organization	CLIP2 KRT27 KRT81 KRT28 KRT83 KRT86 OBSCN APP TRIM27 SPTBN5 NEFL ARHGAP6 RHOBTB1 RHOBTB2 MYPN MICAL3 PLEC PLS3 KRT38 KRT37	9.08e-08	957	107	20	GO:0097435
GeneOntologyBiologicalProcess	neuromuscular synaptic transmission	CHRM1 RIMBP3 RIMBP3C RIMBP3B	3.55e-05	36	107	4	GO:0007274
GeneOntologyCellularComponent	intermediate filament	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL LMNB1 PLEC KRT38 KRT37	2.40e-07	227	106	10	GO:0005882
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL LMNB1 PLEC KRT38 KRT37	9.24e-07	263	106	10	GO:0045111
GeneOntologyCellularComponent	supramolecular fiber	KNTC1 DNAH10 CLIP2 KRT27 KRT81 KRT28 KRT83 KRT86 OBSCN ACTN3 NEFL ARHGAP6 LMNB1 MYPN PYGM PLEC PLS3 KRT38 KRT37 TBCA	1.69e-06	1179	106	20	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	KNTC1 DNAH10 CLIP2 KRT27 KRT81 KRT28 KRT83 KRT86 OBSCN ACTN3 NEFL ARHGAP6 LMNB1 MYPN PYGM PLEC PLS3 KRT38 KRT37 TBCA	1.88e-06	1187	106	20	GO:0099081
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KNTC1 DNAH10 CLIP2 KRT27 KRT81 KRT28 KRT83 KRT86 ACTN3 NEFL ARHGAP6 LMNB1 PLEC PLS3 KRT38 KRT37 TBCA	2.70e-06	899	106	17	GO:0099513
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	3.79e-04	28	106	3	GO:0002177
HumanPheno	Perifollicular hyperkeratosis	KRT81 KRT83 KRT86	3.12e-06	4	48	3	HP:0007468
HumanPheno	Abnormal perifollicular morphology	KRT81 KRT83 KRT86	1.54e-05	6	48	3	HP:0031285
Domain	Filament	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL LMNB1 KRT38 KRT37	2.21e-10	71	105	9	SM01391
Domain	IF	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL LMNB1 KRT38 KRT37	2.51e-10	72	105	9	PS00226
Domain	Filament	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL LMNB1 KRT38 KRT37	2.85e-10	73	105	9	PF00038
Domain	IF	KRT27 KRT81 KRT28 KRT83 KRT86 NEFL LMNB1 KRT38 KRT37	4.12e-10	76	105	9	IPR001664
Domain	Intermediate_filament_CS	KRT81 KRT83 KRT86 NEFL LMNB1 KRT38 KRT37	6.19e-08	63	105	7	IPR018039
Domain	Actinin_actin-bd_CS	ACTN3 SPTBN5 PLEC PLS3	7.69e-06	23	105	4	IPR001589
Domain	ACTININ_2	ACTN3 SPTBN5 PLEC PLS3	7.69e-06	23	105	4	PS00020
Domain	ACTININ_1	ACTN3 SPTBN5 PLEC PLS3	7.69e-06	23	105	4	PS00019
Domain	-	AP2A1 AP2A2	3.13e-05	2	105	2	2.60.40.1030
Domain	AP2_complex_asu	AP2A1 AP2A2	3.13e-05	2	105	2	IPR017104
Domain	Clathrin_a-adaptin_app_sub_C	AP2A1 AP2A2	3.13e-05	2	105	2	IPR003164
Domain	Clathrin_a-adaptin_app_Ig-like	AP2A1 AP2A2	3.13e-05	2	105	2	IPR013038
Domain	Alpha_adaptin_C	AP2A1 AP2A2	3.13e-05	2	105	2	PF02296
Domain	CH	ACTN3 SPTBN5 MICAL3 PLEC PLS3	3.22e-05	65	105	5	SM00033
Domain	CH	ACTN3 SPTBN5 MICAL3 PLEC PLS3	4.62e-05	70	105	5	PF00307
Domain	-	ACTN3 SPTBN5 MICAL3 PLEC PLS3	4.95e-05	71	105	5	1.10.418.10
Domain	CH	ACTN3 SPTBN5 MICAL3 PLEC PLS3	5.66e-05	73	105	5	PS50021
Domain	CH-domain	ACTN3 SPTBN5 MICAL3 PLEC PLS3	6.44e-05	75	105	5	IPR001715
Domain	Keratin_I	KRT27 KRT28 KRT38 KRT37	1.08e-04	44	105	4	IPR002957
Domain	-	AP2A1 AP2A2	1.86e-04	4	105	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	AP2A1 AP2A2	1.86e-04	4	105	2	IPR015873
Domain	Keratin_2_head	KRT81 KRT83 KRT86	3.21e-04	24	105	3	IPR032444
Domain	Keratin_2_head	KRT81 KRT83 KRT86	3.21e-04	24	105	3	PF16208
Domain	Cadherin_CS	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	3.75e-04	109	105	5	IPR020894
Domain	Keratin_II	KRT81 KRT83 KRT86	4.09e-04	26	105	3	IPR003054
Domain	CADHERIN_1	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	4.43e-04	113	105	5	PS00232
Domain	Cadherin	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	4.43e-04	113	105	5	PF00028
Domain	CADHERIN_2	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	4.61e-04	114	105	5	PS50268
Domain	-	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	4.61e-04	114	105	5	2.60.40.60
Domain	CA	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	4.80e-04	115	105	5	SM00112
Domain	Cadherin-like	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	4.99e-04	116	105	5	IPR015919
Domain	Cadherin	FAT4 PCDHA1 CELSR3 DCHS1 CDH16	5.40e-04	118	105	5	IPR002126
Domain	Spectrin_repeat	ACTN3 SPTBN5 PLEC	5.67e-04	29	105	3	IPR002017
Domain	Spectrin/alpha-actinin	ACTN3 SPTBN5 PLEC	7.61e-04	32	105	3	IPR018159
Domain	SPEC	ACTN3 SPTBN5 PLEC	7.61e-04	32	105	3	SM00150
Domain	Coatomer/calthrin_app_sub_C	AP2A1 AP2A2	8.57e-04	8	105	2	IPR009028
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP2A1 AP2A2	1.10e-03	9	105	2	IPR008152
Domain	Alpha_adaptinC2	AP2A1 AP2A2	1.10e-03	9	105	2	PF02883
Domain	Alpha_adaptinC2	AP2A1 AP2A2	1.10e-03	9	105	2	SM00809
Domain	SH3_2	RIMBP3 TJP2 RIMBP3C RIMBP3B	1.41e-03	86	105	4	IPR011511
Domain	SH3_2	RIMBP3 TJP2 RIMBP3C RIMBP3B	1.41e-03	86	105	4	PF07653
Domain	WD40_repeat_dom	KNTC1 IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	1.45e-03	297	105	7	IPR017986
Domain	Coatomer/clathrin_app_Ig-like	AP2A1 AP2A2	1.99e-03	12	105	2	IPR013041
Domain	Clathrin/coatomer_adapt-like_N	AP2A1 AP2A2	3.13e-03	15	105	2	IPR002553
Domain	Adaptin_N	AP2A1 AP2A2	3.13e-03	15	105	2	PF01602
Domain	Quinoprotein_ADH-like_supfam	DMXL2 NWD1 GEMIN5	3.30e-03	53	105	3	IPR011047
Domain	WD40	IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	3.44e-03	259	105	6	PF00400
Domain	Ald_DH_CS_GLU	ALDH2 ALDH1B1	3.57e-03	16	105	2	IPR029510
Domain	Ald_DH_CS_CYS	ALDH2 ALDH1B1	4.03e-03	17	105	2	IPR016160
Domain	WD40	IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	4.07e-03	268	105	6	SM00320
Domain	WD40_repeat	IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	4.37e-03	272	105	6	IPR001680
Domain	ALDEHYDE_DEHYDR_GLU	ALDH2 ALDH1B1	4.52e-03	18	105	2	PS00687
Domain	ALDEHYDE_DEHYDR_CYS	ALDH2 ALDH1B1	4.52e-03	18	105	2	PS00070
Domain	WD_REPEATS_1	IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	4.85e-03	278	105	6	PS00678
Domain	WD_REPEATS_2	IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	4.94e-03	279	105	6	PS50082
Domain	WD_REPEATS_REGION	IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	4.94e-03	279	105	6	PS50294
Domain	Ald_DH_C	ALDH2 ALDH1B1	5.03e-03	19	105	2	IPR016163
Domain	Ald_DH_N	ALDH2 ALDH1B1	5.03e-03	19	105	2	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH2 ALDH1B1	5.03e-03	19	105	2	IPR016161
Domain	-	ALDH2 ALDH1B1	5.03e-03	19	105	2	3.40.605.10
Domain	Aldedh	ALDH2 ALDH1B1	5.03e-03	19	105	2	PF00171
Domain	Aldehyde_DH_dom	ALDH2 ALDH1B1	5.03e-03	19	105	2	IPR015590
Domain	-	ALDH2 ALDH1B1	5.03e-03	19	105	2	3.40.309.10
Domain	Apc4_WD40_dom	NWD1 GEMIN5	5.57e-03	20	105	2	IPR024977
Domain	ANAPC4_WD40	NWD1 GEMIN5	5.57e-03	20	105	2	PF12894
Domain	RHO	RHOBTB1 RHOBTB2	5.57e-03	20	105	2	PS51420
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT27 KRT81 KRT28 KRT83 KRT86 KRT38 KRT37	8.33e-06	129	80	7	M27649
Pathway	REACTOME_RHO_GTPASE_CYCLE	ANKFY1 ESYT1 OBSCN CHN1 ARHGAP6 RHOBTB1 LMNB1 FGD4 NISCH RHOBTB2 TJP2	3.56e-05	439	80	11	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	ANKFY1 ESYT1 OBSCN CHN1 ARHGAP6 RHOBTB1 LMNB1 FGD4 NISCH RHOBTB2 TJP2	4.46e-05	450	80	11	M27078
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT27 KRT81 KRT28 KRT83 KRT86	1.33e-04	87	80	5	MM15351
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	APP CHRM1 ITPR1	2.17e-04	21	80	3	M47689
Pathway	REACTOME_KERATINIZATION	KRT27 KRT81 KRT28 KRT83 KRT86 KRT38 KRT37	2.28e-04	217	80	7	M27640
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	KNTC1 ANKFY1 ESYT1 OBSCN CHN1 ARHGAP6 RHOBTB1 LMNB1 FGD4 NISCH RHOBTB2 TJP2	2.79e-04	649	80	12	MM15690
Pubmed	New consensus nomenclature for mammalian keratins.	KRT27 KRT81 KRT28 KRT83 KRT86 KRT38 KRT37	1.03e-09	63	107	7	16831889
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DENND2A DMXL2 CLIP2 GEMIN5 ACTN3 WDR37 MPRIP NEFL AP2A1 AP2A2 FGD4 NISCH PKM TJP2 MICAL3 ALDH2 PLEC ALDH1B1 CROCC CNOT1 PLS3	2.31e-09	1431	107	21	37142655
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ANKFY1 HLA-C KRT81 KRT86 MCM2 CHN1 TRIM27 MPRIP NEFL ARHGAP6 AP2A1 AP2A2 FGD4 NISCH TJP2 PLEC	2.18e-08	916	107	16	32203420
Pubmed	Novel KRT83 and KRT86 mutations associated with monilethrix.	KRT81 KRT83 KRT86	2.83e-08	3	107	3	25557232
Pubmed	Structure and site of expression of a murine type II hair keratin.	KRT81 KRT83 KRT86	2.83e-08	3	107	3	1372089
Pubmed	Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.	KRT81 KRT83 KRT86	2.83e-08	3	107	3	1712823
Pubmed	The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.	KRT27 KRT28 KRT38 KRT37	4.11e-08	12	107	4	15617563
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KNTC1 ANKFY1 DNAH10 HLA-C ESYT1 GEMIN5 MCM2 CHD4 GTF3C1 AP2A1 LMNB1 AP2A2 PELP1 PKM ALDH2 ALDH1B1 MED23 CNOT1 PLS3	6.77e-08	1425	107	19	30948266
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.13e-07	4	107	3	19091768
Pubmed	Keratins of the human hair follicle.	KRT81 KRT83 KRT86	1.13e-07	4	107	3	15797458
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	MCM2 CHD4 ITPR1 RMI1 LMNB1 PELP1 PKM PYGM ALDH2 PLEC MVP PLS3 PML	1.13e-07	652	107	13	31180492
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ESYT1 GEMIN5 MCM2 CHD4 MPRIP ITPR1 GTF3C1 PELP1 NISCH MED23 PML	1.22e-07	440	107	11	34244565
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MGAT4B PCNX3 ESYT1 KMT5C PIEZO1 OBSCN GEMIN5 CNTROB MPRIP CELSR3 AP2A1 SGSM2 NISCH MICAL3 PLEC ABTB2	2.79e-07	1105	107	16	35748872
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	2.82e-07	5	107	3	17855024
Pubmed	A two-step strategy for constructing specifically self-subtracted cDNA libraries.	ESYT1 ACTN3 CNOT1	2.82e-07	5	107	3	11972353
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DMXL2 CLIP2 KRT83 CHD4 APP SKIL MPRIP NEFL CELSR3 AP2A1 ASCL1 SGSM2 NISCH PKM PLEC MVP COG4	4.03e-07	1285	107	17	35914814
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	KNTC1 ESYT1 GEMIN5 MCM2 CHD4 TRIM27 ITPR1 GTF3C1 AP2A2 PELP1 TJP2 MICAL3 ALDH2 ALDH1B1 CNOT1 PLS3 COG4 PML	4.04e-07	1440	107	18	30833792
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	HLA-C ESYT1 MCM2 APP WDR37 MPRIP AP2A1 NISCH GORAB MICAL3	7.51e-07	421	107	10	36976175
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	APP AP2A1 AP2A2 MVP	1.20e-06	26	107	4	24067654
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT81 KRT83 KRT86 AP2A1 AP2A2 CNOT1 KRT38 KRT37	1.79e-06	266	107	8	19380743
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	KRT81 ESYT1 MCM2 CHD4 AP2A1 LMNB1 AP2A2 PELP1 PKM PLEC ALDH1B1 CNOT1	1.93e-06	707	107	12	19738201
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	GEMIN5 MCM2 CHD4 MED23 CNOT1	2.41e-06	69	107	5	28481362
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	KNTC1 DCP2 MPRIP ITPR1 RMI1 GTF3C1 AP2A1 LMNB1 MYPN RECQL4 PKM PYGM MICAL3 CNOT1 PLS3	2.61e-06	1155	107	15	20360068
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	HLA-C KRT86 MCM2 CHD4 APP NEFL GTF3C1 AP2A1 LMNB1 PELP1 PKM TJP2 PLEC CNOT1	3.23e-06	1024	107	14	24711643
Pubmed	HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.	HLA-C AP2A1 AP2A2	3.34e-06	10	107	3	17581864
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	DMXL2 WDR37 ITPR1 NEFL AP2A1 LMNB1 AP2A2 PKM PLEC	4.54e-06	403	107	9	30562941
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	ANKFY1 ESYT1 GEMIN5 MCM2 CHD4 LMNB1 PELP1 PKM PLEC CNOT1 PLS3	4.58e-06	638	107	11	33239621
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DENND2A IFT140 PIEZO1 UVSSA TBC1D2B MCM2 WDR37 CELSR3 MED23 CNOT1	5.72e-06	529	107	10	14621295
Pubmed	Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.	KRT81 KRT83 KRT86	6.10e-06	12	107	3	10692104
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	DMXL2 CLIP2 WDR37 ITPR1 NEFL PLEC	6.55e-06	147	107	6	16959763
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	COL17A1 HLA-C ESYT1 TRIM27 MPRIP GTF3C1 AP2A1 LMNB1 PELP1 PKM TJP2 PLEC MVP PLS3 PML	7.23e-06	1257	107	15	36526897
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 ANKFY1 CLIP2 CHD4 MPRIP NEFL AP2A1 LMNB1 AP2A2 PELP1 NISCH DCHS1 CNOT1	8.52e-06	963	107	13	28671696
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	HLA-C WDFY4 AP2A1 AP2A2 PLEC PLS3	9.20e-06	156	107	6	30409884
Pubmed	Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.	PKM PML	9.38e-06	2	107	2	18298799
Pubmed	Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.	NEFL ALDH2	9.38e-06	2	107	2	37314537
Pubmed	Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients.	ALDH2 ALDH1B1	9.38e-06	2	107	2	25047496
Pubmed	A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.	KRT83 KRT86	9.38e-06	2	107	2	15744029
Pubmed	Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1.	PIEZO1 APP	9.38e-06	2	107	2	30250223
Pubmed	Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.	ALDH2 ALDH1B1	9.38e-06	2	107	2	23667679
Pubmed	KNTC1 knockdown inhibits the proliferation and migration of osteosarcoma cells by MCM2.	KNTC1 MCM2	9.38e-06	2	107	2	38818892
Pubmed	Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).	AP2A1 AP2A2	9.38e-06	2	107	2	2564002
Pubmed	The Complex Effects of PKM2 and PKM2:IP3R Disruption on Intracellular Ca2+ Handling and Cellular Functions.	ITPR1 PKM	9.38e-06	2	107	2	37947604
Pubmed	Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis.	APP ALDH2	9.38e-06	2	107	2	23447675
Pubmed	A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.	KRT81 KRT86	9.38e-06	2	107	2	9665406
Pubmed	Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.	FAT4 DCHS1	9.38e-06	2	107	2	25355906
Pubmed	A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.	KRT81 KRT86	9.38e-06	2	107	2	9402962
Pubmed	Microglial amyloid beta clearance is driven by PIEZO1 channels.	PIEZO1 APP	9.38e-06	2	107	2	35706029
Pubmed	Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin.	LMNB1 PLEC	9.38e-06	2	107	2	2023931
Pubmed	Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.	ALDH2 ALDH1B1	9.38e-06	2	107	2	23247008
Pubmed	Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women.	ALDH2 ALDH1B1	9.38e-06	2	107	2	32300124
Pubmed	Structure of the planar cell polarity cadherins Fat4 and Dachsous1.	FAT4 DCHS1	9.38e-06	2	107	2	36797229
Pubmed	Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture.	FAT4 DCHS1	9.38e-06	2	107	2	25930014
Pubmed	Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.	AP2A1 AP2A2	9.38e-06	2	107	2	12036598
Pubmed	Epigenetic regulation of plastin 3 expression by the macrosatellite DXZ4 and the transcriptional regulator CHD4.	CHD4 PLS3	9.38e-06	2	107	2	36812914
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.01e-05	14	107	3	17662146
Pubmed	Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors.	APP NEFL ASCL1	1.01e-05	14	107	3	18565209
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	ESYT1 GEMIN5 CHD4 MPRIP RMI1 AP2A1 AP2A2 PELP1	1.08e-05	340	107	8	24332808
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	GEMIN5 MCM2 CHD4 NEFL GTF3C1 AP2A1 AP2A2 NISCH PKM MICAL3 PLEC CNOT1 PLS3 TBCA	1.19e-05	1149	107	14	35446349
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	CELSR3 AP2A1 AP2A2	1.54e-05	16	107	3	24305805
Pubmed	Comprehensive analysis of keratin gene clusters in humans and rodents.	KRT81 KRT83 KRT86	1.54e-05	16	107	3	15085952
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ANKFY1 ESYT1 GEMIN5 MCM2 CHD4 MPRIP GTF3C1 AP2A1 LMNB1 AP2A2 RECQL4 PKM PLEC ALDH1B1 MVP	1.72e-05	1353	107	15	29467282
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	HLA-C CLIP2 ESYT1 DCP2 CHD4 ACTN3 MPRIP AP2A1 LMNB1 AP2A2 PKM TJP2 PLEC CNOT1 PLS3	2.01e-05	1371	107	15	36244648
Pubmed	Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.	GEMIN5 CHD4 LMNB1 MED23	2.21e-05	53	107	4	36841324
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DMXL2 ANKFY1 OBSCN CHD4 ACTN3 MYPN PKM PYGM PLEC	2.40e-05	497	107	9	23414517
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNAH10 SPTBN5 NEFL CELSR3 PLEC CROCC	2.57e-05	187	107	6	26460568
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	ESYT1 TRIM27 ITPR1 LMNB1 AP2A2 PKM PLEC MED23 KRT38	2.64e-05	503	107	9	36217030
Pubmed	PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.	KRT81 KRT83 KRT86	2.65e-05	19	107	3	21285247
Pubmed	Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.	KRT81 KRT28 KRT86	2.65e-05	19	107	3	27234308
Pubmed	Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.	MYF5 PIEZO1	2.81e-05	3	107	2	29799007
Pubmed	Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.	AP2A1 AP2A2	2.81e-05	3	107	2	35014951
Pubmed	A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.	AP2A1 AP2A2	2.81e-05	3	107	2	18032517
Pubmed	The Dictyostelium discoideum family of Rho-related proteins.	RHOBTB1 RHOBTB2	2.81e-05	3	107	2	11222756
Pubmed	Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens.	ALDH2 ALDH1B1	2.81e-05	3	107	2	12693930
Pubmed	Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.	RHOBTB1 RHOBTB2	2.81e-05	3	107	2	27314390
Pubmed	Plasma biomarkers predict Alzheimer's disease before clinical onset in Chinese cohorts.	APP NEFL	2.81e-05	3	107	2	37875471
Pubmed	SnoN functions as a tumour suppressor by inducing premature senescence.	SKIL PML	2.81e-05	3	107	2	19745809
Pubmed	Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.	RHOBTB1 RHOBTB2	2.81e-05	3	107	2	12426103
Pubmed	Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.	TRIM27 PML	2.81e-05	3	107	2	9570750
Pubmed	Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.	APP NEFL	2.81e-05	3	107	2	15731448
Pubmed	The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors.	ALDH2 ALDH1B1	2.81e-05	3	107	2	18782342
Pubmed	AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.	AP2A1 AP2A2	2.81e-05	3	107	2	22262466
Pubmed	Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men.	ALDH2 ALDH1B1	2.81e-05	3	107	2	17471563
Pubmed	Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.	AP2A1 AP2A2	2.81e-05	3	107	2	26269175
Pubmed	Sequence data and chromosomal localization of human type I and type II hair keratin genes.	KRT81 KRT86	2.81e-05	3	107	2	7556444
Pubmed	The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance.	MYF5 PIEZO1	2.81e-05	3	107	2	35648809
Pubmed	A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.	AP2A1 AP2A2	2.81e-05	3	107	2	19129443
Pubmed	Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.	ALDH2 ALDH1B1	2.81e-05	3	107	2	23454351
Pubmed	RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.	TRIM27 PML	2.81e-05	3	107	2	10976108
Pubmed	Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease.	PIEZO1 APP	2.81e-05	3	107	2	36368316
Pubmed	Interaction of Shc with adaptor protein adaptins.	AP2A1 AP2A2	2.81e-05	3	107	2	8617812
Pubmed	Molecular genetics of human aldehyde dehydrogenase.	ALDH2 ALDH1B1	2.81e-05	3	107	2	1306115
Pubmed	Sequences and differential expression of three novel human type-II hair keratins.	KRT83 KRT86	2.81e-05	3	107	2	9084137
Pubmed	The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli.	MYF5 KMT5C	2.81e-05	3	107	2	31001581
Pubmed	The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.	AP2A1 AP2A2	2.81e-05	3	107	2	8662627
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	IFT140 DMXL2 KRT81 KRT83 SMYD5 WDR37 C19orf81 LMNB1 AP2A2 ALDH2 ALDH1B1 MED23 PLS3 ABTB2	2.81e-05	1242	107	14	30973865
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DMXL2 PCDHA1 CHD4 NEFL GTF3C1 AP2A1 LMNB1 PKM PLEC MED23 MVP CNOT1 COG4	2.89e-05	1082	107	13	38697112
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	KRT81 KRT83 KRT86 TRIM27 SGSM2 PLEC CNOT1	2.92e-05	284	107	7	29459677
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	MCM2 LMNB1 PYGM PLEC	3.38e-05	59	107	4	16083285
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	ESYT1 KRT86 MCM2 CHD4 NEFL AP2A1 LMNB1 PKM PLEC MVP TBCA	3.85e-05	803	107	11	36517590
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	ANKFY1 OBSCN CHD4 PKM NUB1 CNOT1 COG4	4.50e-05	304	107	7	32235678
Interaction	KRT6C interactions	KRT27 KRT28 CHD4 ACTN3 PLEC KRT38 KRT37	1.30e-07	76	104	7	int:KRT6C
Interaction	KRT81 interactions	KRT27 KRT81 KRT28 SKIL KRT38 KRT37	3.08e-07	53	104	6	int:KRT81
Interaction	KRT18 interactions	KNTC1 COL17A1 KRT81 MCM2 CHD4 CNTROB NEFL PKM PLEC CNOT1 PLS3 PML	1.72e-06	419	104	12	int:KRT18
Interaction	CAPZA2 interactions	MCM2 MPRIP ITPR1 AP2A1 FGD4 MYPN RECQL4 PKM MICAL3 PLEC CNOT1 PLS3	2.25e-06	430	104	12	int:CAPZA2
Interaction	ECT2 interactions	HLA-C TBC1D2B ACTN3 TRIM27 MPRIP ITPR1 NEFL PELP1 PKM TJP2 MICAL3 NUB1 PLEC ALDH1B1 MVP PLS3 PML	2.80e-06	887	104	17	int:ECT2
Interaction	INA interactions	ANKFY1 KRT27 KRT86 CNTROB RECQL4 PKM PLEC ABTB2	3.21e-06	173	104	8	int:INA
Interaction	SIRT6 interactions	FAT4 ESYT1 GEMIN5 MCM2 CHD4 TRIM27 MPRIP ITPR1 GTF3C1 CELSR3 PELP1 NISCH MED23 PML	4.23e-06	628	104	14	int:SIRT6
Interaction	MAP1LC3A interactions	TBC1D2B APP ARHGAP6 AP2A1 LMNB1 AP2A2 PELP1 MVP PML	4.41e-06	241	104	9	int:MAP1LC3A
Interaction	KRT76 interactions	KRT27 KRT28 KRT86 TRIM27 KRT38 KRT37	4.79e-06	84	104	6	int:KRT76
Interaction	KRT3 interactions	KRT27 KRT28 CHD4 TRIM27 KRT38 KRT37	6.28e-06	88	104	6	int:KRT3
Interaction	GAN interactions	DNAH10 KRT27 SPTBN5 NEFL CELSR3 PLEC CROCC KRT38 KRT37	6.54e-06	253	104	9	int:GAN
Interaction	KCTD13 interactions	DENND2A DMXL2 CLIP2 GEMIN5 ACTN3 WDR37 MPRIP NEFL AP2A1 AP2A2 FGD4 NISCH PKM TJP2 MICAL3 ALDH2 PLEC ALDH1B1 CROCC CNOT1 PLS3	7.44e-06	1394	104	21	int:KCTD13
Interaction	KRT39 interactions	KRT81 KRT83 KRT86 ACTN3 PLEC	1.33e-05	59	104	5	int:KRT39
Interaction	FAM110A interactions	KRT27 TRIM27 PYGM KRT38 COG4 KRT37	1.47e-05	102	104	6	int:FAM110A
Interaction	EXOC4 interactions	KRT27 KRT81 KRT83 KRT86 CNTROB FGD4 KRT38 TBCA	1.47e-05	213	104	8	int:EXOC4
Interaction	USP11 interactions	SMYD5 CHD4 TRIM27 MPRIP AP2A1 LMNB1 AP2A2 PELP1 RECQL4 PKM ALDH1B1 PML	2.19e-05	539	104	12	int:USP11
Interaction	FGFR1 interactions	ANKFY1 ESYT1 OBSCN APP WDR37 AP2A1 NISCH GORAB PKM MICAL3 PLEC PLS3 CDH16	2.24e-05	632	104	13	int:FGFR1
Interaction	KRT83 interactions	KRT27 KRT83 CHD4 KRT38 KRT37	2.68e-05	68	104	5	int:KRT83
Interaction	CCDC40 interactions	APP KRT38 COG4 CCDC40	2.75e-05	34	104	4	int:CCDC40
Interaction	DSCAM interactions	KRT83 SKIL MPRIP NEFL AP2A1 PLEC COG4	2.98e-05	171	104	7	int:DSCAM
Interaction	FBXO3 interactions	DCP2 MCM2 APP RECQL4 PML	3.53e-05	72	104	5	int:FBXO3
Interaction	KRT86 interactions	KRT27 KRT28 KRT86 KRT38 KRT37	4.30e-05	75	104	5	int:KRT86
Interaction	TOP3B interactions	MGAT4B PCNX3 ESYT1 KMT5C PIEZO1 OBSCN GEMIN5 APP CNTROB MPRIP RMI1 CELSR3 AP2A1 PELP1 SGSM2 NISCH MICAL3 PLEC CNOT1 ABTB2	5.48e-05	1470	104	20	int:TOP3B
Interaction	STIP1 interactions	ANKFY1 ESYT1 GEMIN5 MCM2 CHD4 APP WDFY4 SLC12A3 LMNB1 PELP1 RECQL4 PKM PLEC ALDH1B1 CNOT1 PLS3	5.60e-05	1006	104	16	int:STIP1
Interaction	NEFM interactions	KRT27 KRT86 MCM2 NEFL PLEC KRT38 KRT37	5.83e-05	190	104	7	int:NEFM
Interaction	KRT6B interactions	KRT27 KRT28 MCM2 CHD4 KRT38 KRT37	6.32e-05	132	104	6	int:KRT6B
Interaction	NUP210P1 interactions	IFT140 FAT4 CELSR3 DCHS1	6.44e-05	42	104	4	int:NUP210P1
Interaction	CALD1 interactions	WDFY4 MPRIP ITPR1 AP2A2 TJP2 MICAL3 ALDH1B1 PML	6.97e-05	265	104	8	int:CALD1
Interaction	LOC254896 interactions	FAT4 APP NISCH DCHS1	7.07e-05	43	104	4	int:LOC254896
Interaction	KRT71 interactions	KRT27 KRT28 KRT38 KRT37	7.07e-05	43	104	4	int:KRT71
Interaction	KRT78 interactions	KRT27 CHD4 PLEC KRT38 KRT37	8.78e-05	87	104	5	int:KRT78
Interaction	PPP1R9B interactions	DMXL2 WDR37 ITPR1 NEFL AP2A1 LMNB1 AP2A2 PKM TJP2 PYGM PLEC MED23	9.27e-05	626	104	12	int:PPP1R9B
Interaction	KIF20A interactions	CHD4 ACTN3 TRIM27 MPRIP ITPR1 NEFL AP2A1 LMNB1 AP2A2 PELP1 PKM TJP2 PLEC ALDH1B1 KRT38 PML	9.47e-05	1052	104	16	int:KIF20A
Interaction	KRT8 interactions	KRT27 KRT28 TBC1D2B CNTROB NEFL PLEC CNOT1 KRT38 COG4 KRT37	9.49e-05	441	104	10	int:KRT8
Interaction	DCANP1 interactions	FAT4 CELSR3 DCHS1	1.22e-04	19	104	3	int:DCANP1
Interaction	TIPIN interactions	MCM2 APP RECQL4 MED23	1.28e-04	50	104	4	int:TIPIN
Interaction	YWHAZ interactions	DMXL2 CLIP2 ESYT1 MCM2 APP WDR37 MPRIP ITPR1 NEFL VPS13D NISCH RECQL4 TJP2 NUB1 ALDH2 PLEC ALDH1B1 PML	1.32e-04	1319	104	18	int:YWHAZ
Interaction	EPS15 interactions	KRT83 KRT86 AP2A1 AP2A2 KRT38 KRT37 PML	1.46e-04	220	104	7	int:EPS15
Interaction	AP2A1 interactions	ESYT1 MCM2 APP WDFY4 AP2A1 AP2A2 RECQL4 MED23	1.61e-04	299	104	8	int:AP2A1
Interaction	TTN interactions	OBSCN MCM2 CHD4 ACTN3 MYPN PYGM ABTB2 TBCA	1.61e-04	299	104	8	int:TTN
Interaction	PIN1 interactions	MYF5 APP TRIM27 AP2A1 PKM KRT38 KRT37 TBCA PML	1.65e-04	383	104	9	int:PIN1
Interaction	NEFL interactions	KRT27 APP SKIL NEFL FGD4 RHOBTB2	1.88e-04	161	104	6	int:NEFL
Interaction	MMS19 interactions	HLA-C DCP2 MCM2 RHOBTB1 AP2A1 RHOBTB2 RECQL4 PML	2.10e-04	311	104	8	int:MMS19
Interaction	TRIM24 interactions	MCM2 LMNB1 CNOT1 KRT38 KRT37 ABTB2 TBCA CDH16 PML	2.20e-04	398	104	9	int:TRIM24
Interaction	USP2 interactions	KRT27 ACTN3 APP TRIM27 NEFL RECQL4 PML	2.42e-04	239	104	7	int:USP2
Interaction	MAT2B interactions	MCM2 APP TRIM27 AP2A1 RECQL4	2.43e-04	108	104	5	int:MAT2B
Interaction	ARHGAP15 interactions	ESYT1 APP TRIM27 FGD4	2.45e-04	59	104	4	int:ARHGAP15
Interaction	KRT72 interactions	KRT27 KRT28 KRT38 KRT37	2.45e-04	59	104	4	int:KRT72
Interaction	KRT79 interactions	KRT27 KRT28 KRT38 KRT37	2.45e-04	59	104	4	int:KRT79
Interaction	GRB2 interactions	KRT81 KRT83 KRT86 MCM2 APP TRIM27 AP2A1 AP2A2 NISCH RECQL4 PKM PLEC CNOT1	2.59e-04	806	104	13	int:GRB2
Interaction	R3HDML interactions	APP PLEC	2.61e-04	5	104	2	int:R3HDML
Interaction	CDC14A interactions	CHRM1 CNTROB NEFL GTF3C1 AP2A1	2.76e-04	111	104	5	int:CDC14A
Interaction	ZNF581 interactions	KRT27 CHD4 APP TRIM27 RIMBP3C	2.76e-04	111	104	5	int:ZNF581
Interaction	PIAS4 interactions	KNTC1 SKIL TRIM27 MPRIP NEFL PML	2.78e-04	173	104	6	int:PIAS4
Interaction	MTDH interactions	TBC1D2B OBSCN CHD4 SPTBN5 AP2A1 AP2A2 SGSM2 RECQL4 PLEC PML	2.84e-04	505	104	10	int:MTDH
Interaction	KRT4 interactions	KRT27 KRT28 KRT38 KRT37	2.97e-04	62	104	4	int:KRT4
Interaction	IFI16 interactions	ANKFY1 HLA-C OBSCN CHD4 APP MPRIP AP2A2 PELP1 PKM CNOT1 PLS3 PML	3.13e-04	714	104	12	int:IFI16
Interaction	CHEK2 interactions	HLA-C APP MPRIP LMNB1 RHOBTB2 PKM PML	3.18e-04	250	104	7	int:CHEK2
Interaction	EPHA2 interactions	ANKFY1 HLA-C ESYT1 MCM2 APP WDR37 MPRIP AP2A1 NISCH RHOBTB2 GORAB MICAL3	3.33e-04	719	104	12	int:EPHA2
Interaction	EIF4G2 interactions	MCM2 CHD4 SKIL RECQL4 TJP2 PML	3.34e-04	179	104	6	int:EIF4G2
Interaction	FANCM interactions	APP TRIM27 RMI1 PLEC	3.35e-04	64	104	4	int:FANCM
Interaction	CPNE3 interactions	MCM2 CHD4 RECQL4 PKM CROCC	3.38e-04	116	104	5	int:CPNE3
Interaction	APBB3 interactions	APP RHOBTB1 RHOBTB2	3.57e-04	27	104	3	int:APBB3
Interaction	CHMP4B interactions	ESYT1 ACTN3 APP TRIM27 MPRIP ITPR1 NEFL LMNB1 TJP2 PLEC MVP PLS3	3.68e-04	727	104	12	int:CHMP4B
Interaction	HGS interactions	KRT27 KRT86 ACTN3 APP TRIM27 NEFL PELP1 TJP2 KRT38 KRT37	3.74e-04	523	104	10	int:HGS
Interaction	SKIL interactions	KRT81 SKIL NEFL MVP PML	3.81e-04	119	104	5	int:SKIL
Interaction	WHAMMP3 interactions	DMXL2 TBC1D2B WDR37 MPRIP CROCC	3.81e-04	119	104	5	int:WHAMMP3
Interaction	PLEC interactions	COL17A1 MCM2 WDFY4 ITPR1 LMNB1 FGD4 RECQL4 PLEC PLS3	3.87e-04	430	104	9	int:PLEC
Interaction	ITPRID2 interactions	KRT81 KRT83 KRT86 MYPN ABTB2	3.96e-04	120	104	5	int:ITPRID2
Interaction	PSMD14 interactions	DNAH10 APP NEFL VPS13D RECQL4 PKM PLEC MVP PLS3 PML	3.97e-04	527	104	10	int:PSMD14
Interaction	ISOC2 interactions	MCM2 APP RECQL4 PKM	4.00e-04	67	104	4	int:ISOC2
Interaction	EED interactions	KNTC1 ANKFY1 OBSCN GEMIN5 MCM2 CHD4 MPRIP GTF3C1 AP2A1 LMNB1 AP2A2 PKM TJP2 PLEC CROCC MVP CNOT1 PLS3	4.03e-04	1445	104	18	int:EED
Interaction	AAK1 interactions	APP AP2A1 AP2A2 PLEC PML	4.11e-04	121	104	5	int:AAK1
Interaction	MCM2 interactions	MCM2 CHD4 APP AP2A1 LMNB1 AP2A2 MYPN RECQL4 PKM TJP2 PYGM PLEC MVP CNOT1 PML	4.27e-04	1081	104	15	int:MCM2
Interaction	ZBTB46 interactions	CHD4 AP2A1 AP2A2	4.42e-04	29	104	3	int:ZBTB46
Interaction	EPPK1 interactions	KRT27 KRT86 MCM2 CNTROB LMNB1 ASCL1	4.45e-04	189	104	6	int:EPPK1
Interaction	KRT28 interactions	KRT81 KRT28 KRT86	4.90e-04	30	104	3	int:KRT28
Interaction	TRIM32 interactions	MCM2 ACTN3 APP TRIM27 KRT38 KRT37	4.98e-04	193	104	6	int:TRIM32
Interaction	KRT5 interactions	KRT27 KRT28 MCM2 CHD4 KRT38 KRT37	4.98e-04	193	104	6	int:KRT5
Interaction	VPS35 interactions	ANKFY1 DCP2 APP RECQL4 PKM ALDH2 ALDH1B1	5.04e-04	270	104	7	int:VPS35
Cytoband	22q11.21	RIMBP3 RIMBP3C MICAL3 RIMBP3B	1.38e-04	111	107	4	22q11.21
Cytoband	12q13	KRT81 KRT83 KRT86	6.27e-04	71	107	3	12q13
Cytoband	15q22	PKM PML	2.10e-03	29	107	2	15q22
Cytoband	17q12-q21	KRT38 KRT37	2.55e-03	32	107	2	17q12-q21
GeneFamily	Keratins, type I	KRT27 KRT28 KRT38 KRT37	4.91e-06	28	74	4	608
GeneFamily	Keratins, type II	KRT81 KRT83 KRT86	1.79e-04	27	74	3	609
GeneFamily	WD repeat domain containing	IFT140 DMXL2 NWD1 GEMIN5 WDR37 WDFY4	7.11e-04	262	74	6	362
GeneFamily	Cadherin related	FAT4 DCHS1	2.16e-03	17	74	2	24
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ANKFY1 RHOBTB1 RHOBTB2 ABTB2	2.22e-03	134	74	4	861
GeneFamily	Aldehyde dehydrogenases	ALDH2 ALDH1B1	2.70e-03	19	74	2	398
GeneFamily	Rho family GTPases	RHOBTB1 RHOBTB2	2.99e-03	20	74	2	390
Coexpression	GSE7460_TREG_VS_TCONV_ACT_DN	COL17A1 FPGS DCP2 APP AP2A1 RHOBTB2 CNGA1 DSE	1.52e-06	197	107	8	M5691
Coexpression	GSE10422_WT_VS_BAFF_TRANSGENIC_LN_BCELL_UP	PCNX3 WDR37 PELP1 SUSD2 NUB1 CNGA1 PAQR7	9.38e-06	180	107	7	M357
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	ESYT1 TBC1D2B CHD4 TRIM27 ITPR1 NISCH PLEC ALDH1B1	1.81e-05	276	107	8	M3063
Coexpression	GSE12963_ENV_NEF_VS_ENV_NEF_AND_VPR_DEFICIENT_HIV1_INF_CD4_TCELL_UP	MYF5 ANKFY1 RHOBTB2 PYGM CNGA1 PML	1.89e-05	134	107	6	M455
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1 CDH16	7.94e-06	196	107	6	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1 CDH16	7.94e-06	196	107	6	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	CD8+_Memory_T_cell-CV-3\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	HLA-C KRT86 MCM2 SKIL LMNB1 PLEC	8.17e-06	197	107	6	9fe3d53346a95c1bbb0fc6a2f2e974889873424b
ToppCell	CV-Moderate-3\|CV / Virus stimulation, Condition and Cluster	HLA-C KRT86 MCM2 SKIL LMNB1 PLEC	8.17e-06	197	107	6	7031286e300eaccf73b927939f8de3a9d2d5fc74
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	PCNX3 CLIP2 MCM2 SMYD5 GTF3C1 PKM	8.91e-06	200	107	6	ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
ToppCell	TCGA-Bile_Duct-Primary_Tumor\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	PCNX3 CLIP2 MCM2 SMYD5 GTF3C1 PKM	8.91e-06	200	107	6	0350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCell	facs-Heart-LV-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYF5 CHRM1 NEFL SLC12A3 CDH16	2.48e-05	143	107	5	8f82b3c3331f20c6ded36dbfb9a48dbd9f099f93
ToppCell	facs-Heart-LV-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYF5 CHRM1 NEFL SLC12A3 CDH16	2.48e-05	143	107	5	52832321cc848739ff6483f467d57c50c8b7395c
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KRT81 KRT86 AP2A2 MICAL3 ALDH1B1	3.99e-05	158	107	5	74aa4f75307575ac3b2b1aa9f727753692f88742
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	KRT81 KRT86 ARHGAP6 FGD4 DCHS1	5.35e-05	168	107	5	6501495b7ad252af330b18011696c43031541018
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KNTC1 RMI1 SLC12A3 LMNB1 RECQL4	5.50e-05	169	107	5	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RNF25 DCHS1 PYGM ALDH1B1 CCDC17	6.84e-05	177	107	5	8dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RNF25 DCHS1 PYGM ALDH1B1 CCDC17	6.84e-05	177	107	5	767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RNF25 DCHS1 PYGM ALDH1B1 CCDC17	6.84e-05	177	107	5	5ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCell	E18.5-Endothelial-Endothelial_lymphatic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RNF25 DCHS1 PYGM ALDH1B1 CCDC17	6.84e-05	177	107	5	ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCell	wk_20-22-Hematologic-Myeloid-aDC_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	WDFY4 SLC12A3 NUB1 ALDH2 MVP	7.03e-05	178	107	5	fd2bdb4796e86c8cff2d25f0c730ffea21db8787
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PGGHG TBC1D2B AP2A2 ALDH1B1 CNOT1	7.03e-05	178	107	5	c87945146b2734141f07b39d268e0d8086ee0364
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	ESYT1 PGPEP1 SMYD5 MPRIP DCHS1	7.22e-05	179	107	5	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ACTN3 LRRC14B MYPN PYGM	7.41e-05	180	107	5	cea62fc006d68c3815c88bf17ec2617d7e41c3d2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A NWD1 CLIP2 PGPEP1 SLC12A3	7.61e-05	181	107	5	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC-tDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SLC12A3 RIMBP3C ALDH2 MVP PLS3	7.81e-05	182	107	5	ad5c99ec62cdab347d3a03c971d981e3b924020c
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	NWD1 DNAH10 UROC1 CCDC17 CCDC40	8.43e-05	185	107	5	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ACTN3 LRRC14B MYPN PYGM	8.43e-05	185	107	5	9245c322aae8bb9065d50dada198a5ee143a3444
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND2A TBC1D2B OBSCN CHN1 ARHGAP6	8.65e-05	186	107	5	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NWD1 DNAH10 CROCC CCDC17 CCDC40	8.65e-05	186	107	5	85787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell	CV-Severe-3\|Severe / Virus stimulation, Condition and Cluster	KNTC1 KRT86 MCM2 SKIL RECQL4	8.87e-05	187	107	5	68cb43a73945f5e252530da25613f6b3f484b4d5
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 KRT28 MCM2 LMNB1 ASCL1	8.87e-05	187	107	5	38ee33295a21db4aae5ba085df033db9693e41c6
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 KRT28 MCM2 LMNB1 ASCL1	8.87e-05	187	107	5	dbcec24d2c852964736c78e9d81650bff5c455ae
ToppCell	(04)_Pre-ciliated-(3)_72hpi\|(04)_Pre-ciliated / shred by cell type and Timepoint	DNAH10 CNTROB VPS13D CCDC17 CCDC40	9.09e-05	188	107	5	f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	DENND2A IFT140 GEMIN5 MED23 PLS3	9.09e-05	188	107	5	c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|368C / Donor, Lineage, Cell class and subclass (all cells)	DENND2A IFT140 GEMIN5 MED23 PLS3	9.09e-05	188	107	5	9155b9a92496e75646778c025b02947e9e9ec73a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A ITPR1 SLC12A3 PKM CDH16	9.32e-05	189	107	5	55420853f730b433ef58ac9337ac84ac78a247a0
ToppCell	tumor_Lung-T/NK_cells-Exhausted_Tfh\|tumor_Lung / Location, Cell class and cell subclass	HLA-C KRT86 CHN1 ITPR1 PKM	9.80e-05	191	107	5	3e259eba83f8159d1a1a96b98d0e867fe547c5e7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HLA-C CNGA1 PLS3 ABTB2 CDH16	9.80e-05	191	107	5	7235a4d1601c88a2c8af571a2c04ab56d32f1b9a
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1	9.80e-05	191	107	5	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1	9.80e-05	191	107	5	97fb4232417a39801e87725755fd16a57c250209
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1	9.80e-05	191	107	5	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1	9.80e-05	191	107	5	715f5b449b8e075959c05a5b38389df319663164
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1	1.00e-04	192	107	5	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYF5 SKIL PKM ALDH2 MVP	1.00e-04	192	107	5	796e04365b2ea645e14d8970c8c22ff96ddd75de
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B MYPN PYGM ALDH1B1	1.00e-04	192	107	5	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYF5 SKIL PKM ALDH2 MVP	1.00e-04	192	107	5	0134967d36b5dac1e4646d1a555ca8bb4eeac8ef
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NWD1 DNAH10 CROCC CCDC17 CCDC40	1.03e-04	193	107	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CHN1 ARHGAP6 PKM MICAL3 PLS3	1.03e-04	193	107	5	e2b455387d1de7812305200a2041a0f4759a6f54
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP6 RHOBTB1 FGD4 MICAL3 ABTB2	1.05e-04	194	107	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	COL17A1 KRT81 SPTBN5 ASCL1 PYGM	1.16e-04	198	107	5	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH10 KRT81 KRT86 RECQL4 CCDC17	1.19e-04	199	107	5	92778939e9d06599c7d06cfd8f4362b97ed0606b
ToppCell	TCGA-Lung-Primary_Tumor\|TCGA-Lung / Sample_Type by Project: Shred V9	KNTC1 MCM2 SMYD5 LMNB1 RECQL4	1.19e-04	199	107	5	d1d035e987280607266171094db5d6362efe1ad5
ToppCell	(02)_MMP9/10+-(1)_GFP\|(02)_MMP9/10+ / shred by cell type by condition	COL17A1 PIEZO1 PKM PLEC ABTB2	1.19e-04	199	107	5	448ba982be804007f991d469eca9d885b21ae499
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	KNTC1 MCM2 LMNB1 SUSD2 RECQL4	1.19e-04	199	107	5	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 C19orf81 PKM PLS3 CDH16	1.19e-04	199	107	5	a4ebb0598e9a0c9f6e39a0db6d0623654c2a7d88
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	KNTC1 MCM2 SMYD5 LMNB1 RECQL4	1.19e-04	199	107	5	6748d4f76703360071d5f2026d9d06bf30ccfb6d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 C19orf81 PKM PLS3 CDH16	1.19e-04	199	107	5	5059a1d4df7d9989c922007a8dcba98b1f5687d5
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KNTC1 NEFL RMI1 LMNB1 RECQL4	1.22e-04	200	107	5	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
Drug	AC1L9MJT	COL17A1 CLIP2 KRT81 KRT83 KRT86 PLEC KRT38 KRT37	3.07e-06	192	105	8	CID000448959
Drug	Timolol maleate salt [26921-17-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A	ANKFY1 APP ITPR1 SPTBN5 VPS13D ALDH1B1 MVP PML	3.57e-06	196	105	8	6483_UP
Drug	Methylhydantoin-5-(L) [40856-73-3]; Down 200; 35uM; PC3; HT_HG-U133A	DENND2A FAT4 FPGS APP ITPR1 VPS13D CELSR3 PML	4.15e-06	200	105	8	4618_DN
Drug	al-Badry	KRT81 KRT83 KRT86 GTF3C1 KRT38 KRT37 DSE	1.16e-05	165	105	7	CID000004545
Drug	pyrimethamine	KRT81 KRT83 PGPEP1 CHRM1	2.00e-05	35	105	4	CID000004993
Drug	melicopicine	KRT81 KRT83	2.11e-05	2	105	2	CID000101253
Drug	tebuquine	KRT81 KRT83	2.11e-05	2	105	2	CID000071991
Drug	3,5-di-O-galloylquinic acid	KRT81 KRT83	2.11e-05	2	105	2	CID000460896
Drug	sulfur mustard	KRT81 KRT83 KRT86 CNGA1 KRT38 KRT37	3.13e-05	130	105	6	CID000010461
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; PC3; HT_HG-U133A	DENND2A FPGS PGPEP1 SMYD5 AP2A2 RHOBTB2 PML	3.19e-05	193	105	7	4558_DN
Drug	AG-028671 [847803-03-6]; Up 200; 10uM; PC3; HT_HG-U133A	FPGS PGPEP1 CHD4 APP LMNB1 ALDH1B1 COG4	3.40e-05	195	105	7	6557_UP
Drug	Loracarbef [121961-22-6]; Up 200; 10.8uM; HL60; HT_HG-U133A	PIEZO1 FPGS RHOBTB2 ALDH2 PLEC ABTB2 PML	3.40e-05	195	105	7	2970_UP
Drug	Deptropine citrate [2169-75-7]; Down 200; 7.6uM; PC3; HT_HG-U133A	DENND2A ANKFY1 WDR37 ITPR1 GTF3C1 LMNB1 AP2A2	3.63e-05	197	105	7	5118_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; PC3; HT_HG-U133A	CLIP2 FPGS CHD4 APP SGSM2 ABTB2 PML	3.75e-05	198	105	7	2047_DN
Disease	Beaded hair	KRT81 KRT83 KRT86	3.89e-08	3	101	3	cv:C0546966
Disease	MONILETHRIX	KRT81 KRT83 KRT86	3.89e-08	3	101	3	158000
Disease	monilethrix (is_implicated_in)	KRT81 KRT83 KRT86	3.89e-08	3	101	3	DOID:0050472 (is_implicated_in)
Disease	Monilethrix	KRT81 KRT83 KRT86	1.55e-07	4	101	3	C0546966
Disease	Van Maldergem Wetzburger Verloes syndrome	FAT4 DCHS1	1.16e-05	2	101	2	C1832390
Disease	Van Maldergem syndrome	FAT4 DCHS1	1.16e-05	2	101	2	cv:C1832390
Disease	developmental and epileptic encephalopathy 64 (implicated_via_orthology)	RHOBTB1 RHOBTB2	1.16e-05	2	101	2	DOID:0070375 (implicated_via_orthology)
Disease	Periventricular gray matter heterotopia	FAT4 DCHS1	1.16e-05	2	101	2	C1849173
Disease	hair disease (is_implicated_in)	KRT81 KRT86	1.16e-05	2	101	2	DOID:421 (is_implicated_in)
Disease	Heterotopia, Periventricular, Autosomal Recessive	FAT4 DCHS1	3.47e-05	3	101	2	C1842563
Disease	obesity (implicated_via_orthology)	FAT4 DNAH10 ITPR1 DCHS1 ALDH2 ALDH1B1	9.94e-05	215	101	6	DOID:9970 (implicated_via_orthology)
Disease	right ventricular ejection fraction measurement	OBSCN ALDH2 PLEC	1.48e-04	30	101	3	EFO_0021816
Disease	growth differentiation factor 15 measurement	PGPEP1 WDFY4	2.41e-04	7	101	2	EFO_0009181
Disease	alcohol dependence measurement, electroencephalogram measurement	UROC1 DSE	2.41e-04	7	101	2	EFO_0004357, EFO_0007835
Disease	hemoglobin measurement, mean corpuscular hemoglobin concentration	PIEZO1 ALDH2	3.20e-04	8	101	2	EFO_0004509, EFO_0004528
Disease	Hypertrophic Cardiomyopathy	OBSCN MYPN TBCA	9.96e-04	57	101	3	C0007194
Disease	vital capacity	KNTC1 DENND2A PIEZO1 PCDHA1 ACTN3 ITPR1 RMI1 MYPN MICAL3 ALDH2 COG4 TBCA	1.06e-03	1236	101	12	EFO_0004312
Disease	Vascular Diseases	SLC12A3 ALDH2	1.53e-03	17	101	2	C0042373

Protein segments in the cluster

Peptide	Gene	Start	Entry
DILAVLQRDDVRQYL	COL17A1	1086	Q9UMD9
SAAILVVYLDRAQDL	ESYT1	476	Q9BSJ8
TLAAEIRALREAYIR	CCDC17	241	Q96LX7
NDRRRLALENYITAL	APP	466	P05067
YAREQLALRTDLTEA	ALX3	181	O95076
RLYQAIQRADDILDL	COG4	121	Q9H9E3
NRLADLVERDRVYLA	ALDH1B1	106	P30837
LALEIAEERLRFSYN	FAT4	4026	Q6V0I7
RDVSVRQRAADLLYA	AP2A1	381	O95782
YVAEAEEKLQRARLL	CLIP2	406	Q9UDT6
RLYQAVVDARKLLDE	DMXL2	791	Q8TDJ6
DYIELRINDQLARLY	DCP2	161	Q8IU60
IIRENVLALQDDYLA	LVRN	766	Q6Q4G3
ADVELQQRAVEYLRL	AP2A2	571	O94973
RAEAEYIAAKLDIQR	GORAB	226	Q5T7V8
EDRLAIAYDNIVLVL	NWD1	1311	Q149M9
QAARIRYLQAALEVE	RIMBP3B	181	A6NNM3
QAARIRYLQAALEVE	RIMBP3C	181	A6NJZ7
NRESLVVNYEDLAAR	MCM2	226	P49736
RELLDTVDNYAVLQL	NUB1	271	Q9Y5A7
ISRLLAIVADLYEQE	ANKFY1	51	Q9P2R3
VRAALDREAQELYIL	DCHS1	1056	Q96JQ0
LRQVIAEYEALDREL	C19orf81	51	C9J6K1
TLAQLEAVALDYEAR	PAQR7	286	Q86WK9
RLASYLDNVRALEEA	KRT28	96	Q7Z3Y7
NAIRYIESLQELLRE	MYF5	126	P13349
IELENYRLSLRQAEA	MICAL3	891	Q7RTP6
DVEALRRQYLEELQS	MPRIP	801	Q6WCQ1
VDVYQREFLALRDRL	MGAT4B	36	Q9UQ53
AASRDYRNIIERLQD	ITPR1	1601	Q14643
ALETFLRQRDLEAAY	KMT5C	51	Q86Y97
LRQRDLEAAYRALTL	KMT5C	56	Q86Y97
RLENEIATYRNLLES	KRT37	396	O76014
ALIQEIDFLRRLYEE	KRT86	231	O43790
RLENEIATYRNLLES	KRT38	396	O76015
LRELNDRLAVYIDKV	LMNB1	36	P20700
LEAARAAEQLRAYLE	HLA-C	171	P10321
LYDAIAANEERLVIS	PCNX3	1666	Q9H6A9
ADLQDALVILQLYER	PLS3	421	P13797
YNADQLGRALRAIIE	PGPEP1	176	Q9NXJ5
ANELLLTERAYVNRL	FGD4	211	Q96M96
LTERAYVNRLDLLDQ	FGD4	216	Q96M96
LAAREVIAYILERNA	MED23	161	Q9ULK4
LNDRLASYLENVRAL	KRT27	91	Q7Z3Y8
LYFSRAEVAELQLRA	DSE	46	Q9UL01
EAAIYHLQLFEELRR	PKM	386	P14618
QEDEALRRVQYLLLS	KNTC1	1841	P50748
YDEIAEELRAVLLRA	LRRC14B	451	A6NHZ5
EAARAILEYRIRTLD	PGGHG	316	Q32M88
AVAVLRDLLRYAAQL	PELP1	151	Q8IZL8
YEVRASRLELDIEIL	IQCF6	91	A8MYZ5
RELELVYARAQLELE	MVP	766	Q14764
VLDEADLSRYRLLVL	PCDHA1	636	Q9Y5I3
RAQAYRERDILAALS	OBSCN	6506	Q5VST9
ELERARLQEVAFYQL	ARHGAP6	221	O43182
YNAVSERLEQALRLE	CROCC	111	Q5TZA2
EARLNLVIYYLRQDD	TTC26	286	A0AVF1
SLARELIEYQERQLF	DENND2A	551	Q9ULE3
RSAVEYIRALQQLLD	ASCL1	161	P50553
EAQYLAQAEDTRILR	CCDC40	461	Q4G0X9
IYRETENRARELAAL	CHRM1	211	P11229
QLELYVAAAARLTLR	ITIH6	1186	Q6UXX5
LYLARSGLQVEDLDR	FPGS	81	Q05932
EERVNRALALSRYLV	GADL1	406	Q6ZQY3
AALNDIRYQRLVVEL	CHN1	436	P15882
EAEREYALRIRAQDA	CELSR3	611	Q9NYQ7
ELQEQLYVRRAALAA	CELSR3	1351	Q9NYQ7
QALVIEEQLRRAAYL	CHD4	1791	Q14839
EDQLLSVLVAYERRE	DNAH10	3556	Q8IVF4
RAVELLLAARKYQEA	IFT140	1141	Q96RY7
TRELDREAQAEYLLQ	CDH16	291	O75309
YELRLAREQARVCEL	CNTROB	521	Q8N137
ALIQEIDFLRRLYEE	KRT83	236	P78385
YVLLEAALTDLRVQA	SUSD2	471	Q9UGT4
LARLEELDLAIYNSI	TRIM27	201	P14373
EEQLSRAYRLLIAQL	UVSSA	36	Q2YD98
EAEYAGQLAELRQRL	SKIL	626	P12757
QAARIRYLQAALEVE	RIMBP3	181	Q9UFD9
ALLEEYAQEKVLARL	RMI1	196	Q9H9A7
YCNRREDTERIAALL	RECQL4	706	O94761
RAQERELLEAVDARY	PML	291	P29590
QLDLRYADLEAVNRA	RHOBTB2	141	Q9BYZ6
ALALVEAYREIIRDN	SGSM2	951	O43147
QLDLRYADLEAVNRA	RHOBTB1	141	O94844
QDYESLRALAQLRRA	SPTBN5	876	Q9NRC6
RADAYAQLELRTLEQ	ABTB2	316	Q8N961
YDSALLQEVRALLRR	ACTN3	436	Q08043
NRLADLIERDRTYLA	ALDH2	106	P05091
ALQERYLLVRYEDLA	CHST4	266	Q8NCG5
DLLQTRFARILAEYE	CNGA1	631	P29973
FVIDLAALASRREYL	CNOT1	581	A5YKK6
ILAQSRADVYRDILA	TJP2	586	Q9UDY2
LRVIFLENYRVSLAE	PYGM	641	P11217
VLNAARRYLGIEDLA	UROC1	226	Q96N76
IIDLEAERNRYFISL	RNF25	251	Q96BH1
DEAVQALLRAVVRSY	GEMIN5	1221	Q8TEQ6
LYSLVNLDLRDNRIE	NISCH	376	Q9Y2I1
ADIRNAYNEVDSRLI	WDFY4	1301	Q6ZS81
QVRLNEIVLDYSRDA	SLC12A3	956	P55017
AELLESRVIDRELYQ	PLEC	3121	Q15149
NLYIENLELRREIDT	WDR37	71	Q9Y2I8
LIRDARYAEAVQLLG	TTC30A	21	Q86WT1
DVLRAERYLLTQELL	PIEZO1	1541	Q92508
DTLQELFARYRVLAI	GTF3C1	1391	Q12789
QLELLRRLFTEALYE	SMYD5	216	Q6GMV2
DCQRRLEAAYLDLQR	TBCA	66	O75347
NRLVAVALLYLEQED	TBC1D2B	756	Q9UPU7
YQSELELRVAEAARR	VPS13D	661	Q5THJ4
EADYVAQATRLRAAL	HEBP1	141	Q9NRV9
ALIQEIDFLRRLYEE	KRT81	231	Q14533
ELDESVNLARLAINY	MYPN	71	Q86TC9
RALYEQEIRDLRLAA	NEFL	136	P07196