Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane transporter activity

GABRB2 ABCG4 AQP7B SLC22A18 CACNA1F CACNA1S ANO9 SLC28A3 OCA2 ABCG2 KCNMB3 AQP7P3 TMEM87A AQP7 SLC12A5

7.49e-1111803215GO:0022857
GeneOntologyMolecularFunctiontransporter activity

GABRB2 ABCG4 AQP7B SLC22A18 CACNA1F CACNA1S ANO9 SLC28A3 OCA2 ABCG2 KCNMB3 AQP7P3 TMEM87A AQP7 SLC12A5

2.59e-1012893215GO:0005215
GeneOntologyMolecularFunctionchannel activity

GABRB2 AQP7B CACNA1F CACNA1S ANO9 OCA2 KCNMB3 AQP7P3 TMEM87A AQP7 SLC12A5

2.93e-105253211GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GABRB2 AQP7B CACNA1F CACNA1S ANO9 OCA2 KCNMB3 AQP7P3 TMEM87A AQP7 SLC12A5

2.99e-105263211GO:0022803
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRB2 AQP7B CACNA1F CACNA1S ANO9 SLC28A3 OCA2 KCNMB3 AQP7P3 TMEM87A AQP7 SLC12A5

9.22e-107583212GO:0015318
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR1F1 FZD1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 FZD2 AVPR1A FZD3 OR4L1

6.60e-088843211GO:0004930
GeneOntologyMolecularFunctionglycerol channel activity

AQP7B AQP7P3 AQP7

1.30e-077323GO:0015254
GeneOntologyMolecularFunctionglycerol transmembrane transporter activity

AQP7B AQP7P3 AQP7

3.12e-079323GO:0015168
GeneOntologyMolecularFunctionurea transmembrane transporter activity

AQP7B AQP7P3 AQP7

3.12e-079323GO:0015204
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR1F1 FZD1 GABRB2 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 FZD2 AVPR1A FZD3 OR4L1

5.64e-0713533212GO:0004888
GeneOntologyMolecularFunctionamide transmembrane transporter activity

AQP7B ABCG2 AQP7P3 AQP7

5.82e-0742324GO:0042887
GeneOntologyMolecularFunctionpolyol transmembrane transporter activity

AQP7B AQP7P3 AQP7

1.06e-0613323GO:0015166
GeneOntologyMolecularFunctionWnt receptor activity

FZD1 FZD2 FZD3

2.50e-0617323GO:0042813
GeneOntologyMolecularFunctionwater channel activity

AQP7B AQP7P3 AQP7

2.50e-0617323GO:0015250
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRB2 CACNA1F CACNA1S ANO9 SLC28A3 OCA2 KCNMB3 TMEM87A SLC12A5

2.89e-06793329GO:0015075
GeneOntologyMolecularFunctionwater transmembrane transporter activity

AQP7B AQP7P3 AQP7

4.18e-0620323GO:0005372
GeneOntologyMolecularFunctionolfactory receptor activity

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

4.39e-06431327GO:0004984
GeneOntologyMolecularFunctionorganic hydroxy compound transmembrane transporter activity

ABCG4 AQP7B AQP7P3 AQP7

4.62e-0670324GO:1901618
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRB2 CACNA1F CACNA1S ANO9 OCA2 KCNMB3 TMEM87A

6.63e-06459327GO:0005216
GeneOntologyMolecularFunctiongated channel activity

GABRB2 CACNA1F CACNA1S ANO9 KCNMB3 TMEM87A

1.31e-05334326GO:0022836
GeneOntologyMolecularFunctionWnt-protein binding

FZD1 FZD2 FZD3

2.16e-0534323GO:0017147
GeneOntologyMolecularFunctionurea channel activity

AQP7P3 AQP7

2.48e-055322GO:0015265
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

AQP7B AQP7P3 AQP7

4.11e-0542323GO:0015144
GeneOntologyMolecularFunctionPDZ domain binding

FZD1 FZD2 FZD3 CASK

4.31e-05123324GO:0030165
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

GABRB2 ANO9 OCA2 SLC12A5

4.59e-05125324GO:0015108
GeneOntologyMolecularFunctionCDP-alcohol phosphatidyltransferase activity

CDS1 PTDSS2

6.92e-058322GO:0017169
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1F CACNA1S SLC28A3 KCNMB3 TMEM87A SLC12A5

8.37e-05465326GO:0046873
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GABRB2 ANO9 OCA2 SLC12A5

9.58e-05151324GO:0008509
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GABRB2 ANO9 OCA2 SLC12A5

1.55e-04171324GO:0015103
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1F CACNA1S

2.24e-0414322GO:0008331
GeneOntologyMolecularFunctionchloride channel activity

GABRB2 ANO9 OCA2

3.50e-0486323GO:0005254
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1F CACNA1S SLC28A3 KCNMB3 TMEM87A SLC12A5

4.22e-04627326GO:0022890
GeneOntologyMolecularFunctionphosphotransferase activity, for other substituted phosphate groups

CDS1 PTDSS2

5.63e-0422322GO:0016780
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1F CACNA1S SLC28A3 KCNMB3 TMEM87A SLC12A5

5.72e-04664326GO:0008324
GeneOntologyMolecularFunctionmonoatomic anion channel activity

GABRB2 ANO9 OCA2

5.93e-04103323GO:0005253
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCG4 SLC22A18 SLC28A3 ABCG2 SLC12A5

9.00e-04477325GO:0022804
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

SLC22A18 ABCG2

1.35e-0334322GO:0042910
GeneOntologyMolecularFunctionsymporter activity

SLC22A18 SLC28A3 SLC12A5

1.76e-03150323GO:0015293
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1F CACNA1S KCNMB3 TMEM87A

2.10e-03343324GO:0005261
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNMB3 TMEM87A SLC12A5

2.38e-03167323GO:0015079
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1F CACNA1S

2.46e-0346322GO:0005245
GeneOntologyMolecularFunctionABC-type transporter activity

ABCG4 ABCG2

2.79e-0349322GO:0140359
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRB2 ANO9

2.91e-0350322GO:0099095
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRB2 ANO9 KCNMB3

3.59e-03193323GO:0015276
GeneOntologyMolecularFunctionlipid transporter activity

ABCG4 ANO9 ABCG2

3.75e-03196323GO:0005319
GeneOntologyMolecularFunctionligand-gated channel activity

GABRB2 ANO9 KCNMB3

3.80e-03197323GO:0022834
GeneOntologyMolecularFunctionprotein kinase C binding

AVPR1A CASK

5.01e-0366322GO:0005080
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC22A18 SLC28A3 SLC12A5

1.16e-02296323GO:0015291
GeneOntologyMolecularFunctionprotein domain specific binding

FZD1 AP2M1 FZD2 FZD3 CASK

1.20e-02875325GO:0019904
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCG4 ABCG2

1.32e-02109322GO:0042626
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC28A3 SLC12A5

1.55e-02119322GO:0015294
GeneOntologyMolecularFunctionpotassium channel activity

KCNMB3 TMEM87A

1.78e-02128322GO:0005267
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1F CACNA1S

1.81e-02129322GO:0005262
GeneOntologyBiologicalProcessdetection of stimulus

OR1F1 OR7D4 CACNA1F OR1A2 CDS1 OR8J3 OR2A5 KCNMB3 OR2T6 TMEM87A OR4L1

5.91e-097223211GO:0051606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR1F1 OR7D4 CACNA1F OR1A2 OR8J3 OR2A5 OR2T6 TMEM87A OR4L1

1.67e-07582329GO:0050906
GeneOntologyBiologicalProcessglycerol transmembrane transport

AQP7B AQP7P3 AQP7

2.83e-079323GO:0015793
GeneOntologyBiologicalProcesssensory perception of smell

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 FZD2 OR4L1

4.11e-07465328GO:0007608
GeneOntologyBiologicalProcesspolyol transmembrane transport

AQP7B AQP7P3 AQP7

7.39e-0712323GO:0015791
GeneOntologyBiologicalProcessurea transmembrane transport

AQP7B AQP7P3 AQP7

7.39e-0712323GO:0071918
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 KCNMB3 OR2T6 OR4L1

1.01e-06524328GO:0009593
GeneOntologyBiologicalProcessurea transport

AQP7B AQP7P3 AQP7

1.22e-0614323GO:0015840
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 FZD2 OR4L1

1.39e-06547328GO:0007606
GeneOntologyBiologicalProcesssensory perception

OR1F1 OR7D4 CACNA1F OR1A2 OR8J3 OR2A5 OR2T6 FZD2 TMEM87A OR4L1

3.12e-0610723210GO:0007600
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

3.60e-06432327GO:0050911
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR1F1 FZD1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 FZD2 AVPR1A FZD3 OR4L1

4.46e-0613953211GO:0007186
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

7.70e-06485327GO:0050907
GeneOntologyBiologicalProcessmonoatomic anion transport

GABRB2 SLC22A18 ANO9 OCA2 SLC12A5

8.63e-06183325GO:0006820
GeneOntologyBiologicalProcesswater transport

AQP7B AQP7P3 AQP7

1.63e-0532323GO:0006833
GeneOntologyBiologicalProcessone-carbon compound transport

AQP7B AQP7P3 AQP7

1.79e-0533323GO:0019755
GeneOntologyBiologicalProcesschloride transmembrane transport

GABRB2 ANO9 OCA2 SLC12A5

2.63e-05112324GO:1902476
GeneOntologyBiologicalProcessmonoatomic ion transport

GABRB2 SLC22A18 CACNA1F CACNA1S ANO9 SLC28A3 OCA2 KCNMB3 SLC12A5 CASK

2.77e-0513743210GO:0006811
GeneOntologyBiologicalProcessmuscular septum morphogenesis

FZD1 FZD2

3.48e-056322GO:0003150
GeneOntologyBiologicalProcessfluid transport

AQP7B AQP7P3 AQP7

3.74e-0542323GO:0042044
GeneOntologyBiologicalProcessestablishment of planar polarity

FZD1 FZD2 FZD3

4.30e-0544323GO:0001736
GeneOntologyBiologicalProcesschloride transport

GABRB2 ANO9 OCA2 SLC12A5

4.45e-05128324GO:0006821
GeneOntologyBiologicalProcessestablishment of tissue polarity

FZD1 FZD2 FZD3

4.60e-0545323GO:0007164
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

GABRB2 ANO9 OCA2 SLC12A5

5.32e-05134324GO:0098661
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

FZD1 FZD2 FZD3

8.42e-0555323GO:0060071
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

GABRB2 ANO9 OCA2 SLC12A5

8.90e-05153324GO:0098656
GeneOntologyBiologicalProcessmembranous septum morphogenesis

FZD1 FZD2

1.04e-0410322GO:0003149
GeneOntologyBiologicalProcessrenal water absorption

AQP7P3 AQP7

1.04e-0410322GO:0070295
GeneOntologyBiologicalProcesshard palate development

FZD1 FZD2

1.04e-0410322GO:0060022
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

GABRB2 CACNA1F CACNA1S ANO9 SLC28A3 OCA2 KCNMB3 SLC12A5

1.24e-041017328GO:0098660
GeneOntologyBiologicalProcessxenobiotic transport

SLC22A18 SLC28A3 ABCG2

1.33e-0464323GO:0042908
GeneOntologyBiologicalProcessinorganic anion transport

GABRB2 ANO9 OCA2 SLC12A5

1.67e-04180324GO:0015698
GeneOntologyBiologicalProcessrenal water transport

AQP7P3 AQP7

1.80e-0413322GO:0003097
GeneOntologyBiologicalProcessmorphogenesis of a polarized epithelium

FZD1 FZD2 FZD3

1.96e-0473323GO:0001738
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

FZD1 FZD2 FZD3

2.30e-0477323GO:0035567
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

GABRB2 CACNA1F CACNA1S ANO9 SLC28A3 OCA2 KCNMB3 SLC12A5

2.34e-041115328GO:0034220
GeneOntologyBiologicalProcessregulation of establishment of planar polarity involved in neural tube closure

FZD1 FZD2

2.42e-0415322GO:0090178
GeneOntologyBiologicalProcessestablishment of planar polarity involved in neural tube closure

FZD1 FZD2

2.76e-0416322GO:0090177
GeneOntologyBiologicalProcessestablishment of planar polarity of embryonic epithelium

FZD1 FZD2

3.51e-0418322GO:0042249
GeneOntologyBiologicalProcessregulation of establishment of planar polarity

FZD1 FZD2

3.92e-0419322GO:0090175
GeneOntologyBiologicalProcessregulation of intracellular pH

OCA2 AVPR1A SLC12A5

4.13e-0494323GO:0051453
GeneOntologyBiologicalProcessamide transport

AQP7B ABCG2 AQP7P3 AQP7 CASK

4.37e-04420325GO:0042886
GeneOntologyBiologicalProcesscalcium ion import

CACNA1F CACNA1S CASK

4.67e-0498323GO:0070509
GeneOntologyBiologicalProcesschemical homeostasis

ABCG4 CACNA1F CACNA1S OCA2 AQP7P3 AVPR1A AQP7 SLC12A5

5.03e-041249328GO:0048878
GeneOntologyBiologicalProcessregulation of cellular pH

OCA2 AVPR1A SLC12A5

5.10e-04101323GO:0030641
GeneOntologyBiologicalProcessneural tube closure

FZD1 FZD2 FZD3

7.07e-04113323GO:0001843
GeneOntologyBiologicalProcesstube closure

FZD1 FZD2 FZD3

7.26e-04114323GO:0060606
GeneOntologyBiologicalProcessrenal water homeostasis

AQP7P3 AQP7

7.40e-0426322GO:0003091
GeneOntologyBiologicalProcesssecondary palate development

FZD1 FZD2

7.99e-0427322GO:0062009
GeneOntologyBiologicalProcessxenobiotic detoxification by transmembrane export across the plasma membrane

SLC22A18 ABCG2

7.99e-0427322GO:1990961
GeneOntologyBiologicalProcessprimary neural tube formation

FZD1 FZD2 FZD3

8.42e-04120323GO:0014020
GeneOntologyBiologicalProcessregulation of pH

OCA2 AVPR1A SLC12A5

8.42e-04120323GO:0006885
GeneOntologyBiologicalProcessxenobiotic export from cell

SLC22A18 ABCG2

9.22e-0429322GO:0046618
GeneOntologyBiologicalProcessneural tube formation

FZD1 FZD2 FZD3

1.16e-03134323GO:0001841
GeneOntologyBiologicalProcessmulticellular organismal-level water homeostasis

AQP7P3 AQP7

1.34e-0335322GO:0050891
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1F CACNA1S SLC12A5

1.37e-03142323GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1F CACNA1S SLC12A5

1.37e-03142323GO:0098659
GeneOntologyBiologicalProcessrenal system process

ABCG2 AQP7P3 AQP7

1.57e-03149323GO:0003014
GeneOntologyBiologicalProcessembryonic epithelial tube formation

FZD1 FZD2 FZD3

1.89e-03159323GO:0001838
GeneOntologyBiologicalProcessorganic hydroxy compound transport

ABCG4 AQP7B AQP7P3 AQP7

2.19e-03358324GO:0015850
GeneOntologyBiologicalProcesscarbohydrate transmembrane transport

AQP7B AQP7P3 AQP7

2.21e-03168323GO:0034219
GeneOntologyBiologicalProcessrenal absorption

AQP7P3 AQP7

2.21e-0345322GO:0070293
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

CACNA1F CACNA1S OCA2 AVPR1A SLC12A5

2.33e-03611325GO:0030003
GeneOntologyBiologicalProcessepithelial tube formation

FZD1 FZD2 FZD3

2.41e-03173323GO:0072175
GeneOntologyBiologicalProcessdetection of external stimulus

CACNA1F CDS1 TMEM87A

2.41e-03173323GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

CACNA1F CDS1 TMEM87A

2.49e-03175323GO:0009582
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1F CACNA1S

2.52e-0348322GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1F CACNA1S

2.52e-0348322GO:1902656
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

CACNA1F CACNA1S OCA2 AVPR1A SLC12A5

2.52e-03622325GO:0006873
GeneOntologyBiologicalProcesscarbohydrate transport

AQP7B AQP7P3 AQP7

2.95e-03186323GO:0008643
GeneOntologyBiologicalProcesstube formation

FZD1 FZD2 FZD3

3.00e-03187323GO:0035148
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

FZD1 FZD2 FZD3

3.14e-03190323GO:0016331
GeneOntologyBiologicalProcessventricular septum morphogenesis

FZD1 FZD2

3.41e-0356322GO:0060412
GeneOntologyBiologicalProcessintracellular pH reduction

AVPR1A SLC12A5

3.65e-0358322GO:0051452
GeneOntologyBiologicalProcessneural tube development

FZD1 FZD2 FZD3

3.72e-03202323GO:0021915
GeneOntologyBiologicalProcessmetal ion transport

CACNA1F CACNA1S SLC28A3 KCNMB3 SLC12A5 CASK

3.92e-031000326GO:0030001
GeneOntologyBiologicalProcesscochlea development

GABRB2 FZD2

4.03e-0361322GO:0090102
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

CACNA1F CACNA1S OCA2 AVPR1A SLC12A5

4.31e-03705325GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CACNA1F CACNA1S OCA2 AVPR1A SLC12A5

4.63e-03717325GO:0050801
GeneOntologyCellularComponentbrush border membrane

SLC28A3 ABCG2 AQP7P3 AQP7

7.63e-0683324GO:0031526
GeneOntologyCellularComponentcell projection membrane

SLC28A3 ABCG2 AQP7P3 AQP7 SLC12A5 CASK

4.27e-05431326GO:0031253
GeneOntologyCellularComponentbrush border

SLC28A3 ABCG2 AQP7P3 AQP7

8.25e-05152324GO:0005903
GeneOntologyCellularComponentcluster of actin-based cell projections

SLC28A3 ABCG2 AQP7P3 AQP7

3.59e-04223324GO:0098862
GeneOntologyCellularComponentpresynaptic membrane

GABRB2 AP2M1 FZD3 CASK

8.10e-04277324GO:0042734
GeneOntologyCellularComponentbasolateral plasma membrane

AQP7B AQP7P3 AQP7 CASK

1.38e-03320324GO:0016323
GeneOntologyCellularComponentsynaptic membrane

GABRB2 AP2M1 FZD3 SLC12A5 CASK

1.79e-03583325GO:0097060
GeneOntologyCellularComponentbasal plasma membrane

AQP7B AQP7P3 AQP7 CASK

2.00e-03354324GO:0009925
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1F CACNA1S

2.25e-0346322GO:0005891
GeneOntologyCellularComponentbasal part of cell

AQP7B AQP7P3 AQP7 CASK

2.54e-03378324GO:0045178
GeneOntologyCellularComponentmonoatomic ion channel complex

GABRB2 CACNA1F CACNA1S KCNMB3

2.54e-03378324GO:0034702
GeneOntologyCellularComponentcytoplasmic vesicle membrane

GABRB2 ABCG4 OCA2 AP2M1 GOSR2 FZD2 AQP7

3.11e-031307327GO:0030659
GeneOntologyCellularComponentvesicle membrane

GABRB2 ABCG4 OCA2 AP2M1 GOSR2 FZD2 AQP7

3.35e-031325327GO:0012506
MousePhenodecreased urine glycerol level

AQP7P3 AQP7

2.59e-062232MP:0030781
MousePhenoabnormal urine glycerol level

AQP7P3 AQP7

7.76e-063232MP:0030782
MousePhenodecreased PP cell number

AQP7P3 AQP7

3.87e-056232MP:0009186
MousePhenoabnormal PP cell morphology

AQP7P3 AQP7

7.21e-058232MP:0009184
MousePhenoincreased circulating insulin level

CACNA1F OCA2 ABCG2 AQP7P3 AQP7

8.19e-05283235MP:0002079
MousePhenoincreased circulating hormone level

CACNA1F PTDSS2 OCA2 ABCG2 AQP7P3 AQP7

2.69e-04578236MP:0014456
DomainFrizzled

FZD1 FZD2 FZD3

5.51e-0711293IPR000539
DomainFrizzled

FZD1 FZD2 FZD3

5.51e-0711293PF01534
DomainFrizzled

FZD1 FZD2 FZD3

5.51e-0711293SM01330
DomainOlfact_rcpt

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

1.81e-06393297IPR000725
DomainFrizzled/SFRP

FZD1 FZD2 FZD3

1.86e-0616293IPR015526
DomainFRI

FZD1 FZD2 FZD3

3.77e-0620293SM00063
Domain-

FZD1 FZD2 FZD3

4.39e-06212931.10.2000.10
DomainGPCR_Rhodpsn_7TM

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 AVPR1A OR4L1

5.78e-06670298IPR017452
Domain7tm_1

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 AVPR1A OR4L1

6.24e-06677298PF00001
DomainFrizzled_dom

FZD1 FZD2 FZD3

6.66e-0624293IPR020067
DomainFZ

FZD1 FZD2 FZD3

6.66e-0624293PS50038
DomainFz

FZD1 FZD2 FZD3

6.66e-0624293PF01392
DomainG_PROTEIN_RECEP_F1_1

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 AVPR1A OR4L1

6.81e-06685298PS00237
DomainG_PROTEIN_RECEP_F1_2

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 AVPR1A OR4L1

7.26e-06691298PS50262
DomainGPCR_Rhodpsn

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 AVPR1A OR4L1

7.33e-06692298IPR000276
DomainVDCC_L_a1su

CACNA1F CACNA1S

1.39e-054292IPR005446
DomainABC_2_trans

ABCG4 ABCG2

2.32e-055292IPR013525
DomainABC2_membrane

ABCG4 ABCG2

2.32e-055292PF01061
DomainCa_chan_IQ

CACNA1F CACNA1S

4.87e-057292PF08763
DomainGPHH

CACNA1F CACNA1S

4.87e-057292PF16905
DomainGPHH_dom

CACNA1F CACNA1S

4.87e-057292IPR031649
DomainVDCC_a1su_IQ

CACNA1F CACNA1S

4.87e-057292IPR014873
DomainCa_chan_IQ

CACNA1F CACNA1S

4.87e-057292SM01062
DomainVDCCAlpha1

CACNA1F CACNA1S

1.04e-0410292IPR002077
DomainGPCR_2-like

FZD1 FZD2 FZD3

1.09e-0460293IPR017981
DomainGPCR_2_secretin-like

FZD1 FZD2 FZD3

1.09e-0460293IPR000832
DomainG_PROTEIN_RECEP_F2_4

FZD1 FZD2 FZD3

1.14e-0461293PS50261
DomainABC_TRANSPORTER_2

ABCG4 ABCG2

2.51e-0348292PS50893
DomainABC_tran

ABCG4 ABCG2

2.51e-0348292PF00005
DomainABC_TRANSPORTER_1

ABCG4 ABCG2

2.62e-0349292PS00211
DomainABC_transporter-like

ABCG4 ABCG2

2.72e-0350292IPR003439
DomainChannel_four-helix_dom

CACNA1F CACNA1S

3.52e-0357292IPR027359
Domain-

CACNA1F CACNA1S

3.52e-03572921.20.120.350
DomainIon_trans_dom

CACNA1F CACNA1S

1.35e-02114292IPR005821
DomainIon_trans

CACNA1F CACNA1S

1.35e-02114292PF00520
DomainAAA+_ATPase

ABCG4 ABCG2

2.09e-02144292IPR003593
DomainAAA

ABCG4 ABCG2

2.09e-02144292SM00382
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD1 FZD2 FZD3

3.12e-0614303M47834
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD1 FZD2 FZD3

4.78e-0616303M47823
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD1 FZD2 FZD3

8.24e-0619303M47833
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

1.36e-05389307M14091
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

2.13e-05417307M4072
PathwayREACTOME_PCP_CE_PATHWAY

FZD1 AP2M1 FZD2 FZD3

2.99e-0585304MM15041
PathwayREACTOME_SENSORY_PERCEPTION

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1 CASK

3.98e-05636308M41834
PathwayREACTOME_PCP_CE_PATHWAY

FZD1 AP2M1 FZD2 FZD3

4.09e-0592304M27322
PathwayWP_GPCRS_OTHER

OR1F1 FZD1 OR1A2 FZD2

4.83e-0596304MM15939
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD2 FZD3

5.92e-0536303M39699
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ABCG4 SLC22A18 ANO9 SLC28A3 AP2M1 AQP7P3 AQP7 SLC12A5

6.46e-05681308MM14985
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1F CACNA1S

6.53e-056302M47762
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

CACNA1F CACNA1S KCNMB3 AVPR1A

9.78e-05115304M9387
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD2 FZD3

1.09e-0444303MM15878
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ABCG4 SLC22A18 ANO9 SLC28A3 AP2M1 ABCG2 AQP7 SLC12A5

1.11e-04736308M27287
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

FZD1 FZD2 FZD3

1.16e-0445303M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

FZD1 FZD2 FZD3

1.24e-0446303M47409
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

FZD1 AP2M1 FZD2 FZD3

1.27e-04123304MM14988
PathwayWP_ALZHEIMERS_DISEASE

FZD1 CACNA1F CACNA1S FZD2 FZD3

2.04e-04261305M42565
PathwayKEGG_BASAL_CELL_CARCINOMA

FZD1 FZD2 FZD3

2.12e-0455303M17807
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

FZD1 AP2M1 FZD2 FZD3

2.45e-04146304M27288
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD1 FZD2 FZD3

2.74e-0460303MM15150
PathwayREACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2

AP2M1 FZD2

2.85e-0412302MM15163
PathwayWP_WNT_SIGNALING

FZD1 FZD2 FZD3

2.88e-0461303MM15893
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD1 FZD2 FZD3

3.32e-0464303M27396
PathwayREACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS

AQP7P3 AQP7

3.37e-0413302MM15095
PathwayREACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2

AP2M1 FZD2

3.37e-0413302M27415
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

FZD1 FZD2 FZD3

3.64e-0466303M39642
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1F CACNA1S

3.92e-0414302M47692
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR7D4 OR1A2 OR4L1

4.32e-0470303MM14984
PathwayWP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS

FZD1 CACNA1F CACNA1S FZD2 FZD3

5.68e-04326305M39379
PathwayPID_ARF_3PATHWAY

AP2M1 GOSR2

7.32e-0419302M243
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

FZD1 FZD2 FZD3

7.64e-0485303M48315
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

FZD1 FZD2 FZD3

8.73e-0489303M39563
PathwayWNT_SIGNALING

FZD1 FZD2 FZD3

8.73e-0489303M5493
PathwayWP_GLYCEROLIPIDS_AND_GLYCEROPHOSPHOLIPIDS

CDS1 PTDSS2

9.85e-0422302M39362
PathwayREACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

FZD1 FZD2 FZD3

1.02e-0394303M797
PathwayWP_GLYCEROLIPIDS_AND_GLYCEROPHOSPHOLIPIDS

CDS1 PTDSS2

1.08e-0323302MM15993
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1F CACNA1S

1.08e-0323302M47666
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

FZD1 FZD2 FZD3

1.15e-0398303M39731
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

FZD1 FZD2 FZD3

1.26e-03101303MM15829
PathwayKEGG_MELANOGENESIS

FZD1 FZD2 FZD3

1.26e-03101303M7761
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

FZD1 FZD2 FZD3

1.26e-03101303M39387
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1F CACNA1S

1.27e-0325302M47948
PathwayREACTOME_SIGNALING_BY_WNT

FZD1 AP2M1 FZD2 FZD3

1.56e-03239304MM14756
PathwayPID_WNT_SIGNALING_PATHWAY

FZD1 FZD2

1.60e-0328302M77
PathwayWP_WNT_SIGNALING_WP428

FZD1 FZD2 FZD3

1.74e-03113303M39669
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

FZD1 FZD2 FZD3

1.87e-03116303MM15863
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

FZD1 FZD2 FZD3

1.92e-03117303M39530
PathwayWP_GABA_RECEPTOR_SIGNALING

GABRB2 AP2M1

1.96e-0331302M39369
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

FZD1 FZD2

1.96e-0331302M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

FZD1 FZD2

1.96e-0331302MM15154
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

FZD1 FZD2 FZD3

1.97e-03118303M39852
PathwayWP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS

GABRB2 ABCG4 SLC12A5

2.02e-03119303M48309
PathwayWP_GPCRS_NONODORANT

FZD1 FZD2 AVPR1A FZD3

2.31e-03266304MM15843
PathwayWP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION

GABRB2 SLC12A5

2.93e-0338302M39854
PathwayREACTOME_AQUAPORIN_MEDIATED_TRANSPORT

AQP7P3 AQP7

3.25e-0340302MM15115
PathwayKEGG_ABC_TRANSPORTERS

ABCG4 ABCG2

3.92e-0344302M11911
PathwayKEGG_WNT_SIGNALING_PATHWAY

FZD1 FZD2 FZD3

3.96e-03151303M19428
PathwayREACTOME_CA2_PATHWAY

FZD2 FZD3

4.09e-0345302MM15040
PathwayWP_BREAST_CANCER_PATHWAY

FZD1 FZD2 FZD3

4.18e-03154303M39739
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

FZD1 FZD2 FZD3

4.73e-03161303M39770
PathwayREACTOME_SIGNALING_BY_WNT

FZD1 AP2M1 FZD2 FZD3

5.00e-03330304M7847
PathwayREACTOME_NEURONAL_SYSTEM

GABRB2 AP2M1 KCNMB3 CASK

5.27e-03335304MM14503
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1F CACNA1S AVPR1A

6.26e-03178303M2890
PathwayREACTOME_SENSORY_PERCEPTION

OR7D4 OR1A2 OR4L1

7.49e-03190303MM15687
PathwayREACTOME_CA2_PATHWAY

FZD2 FZD3

7.65e-0362302M27321
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

GABRB2 AP2M1 CASK

9.22e-03205303M752
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

GABRB2 AP2M1 CASK

9.97e-03211303MM14502
PathwayWP_PPAR_SIGNALING_PATHWAY

AQP7P3 AQP7

1.05e-0273302MM15995
PathwayREACTOME_NEURONAL_SYSTEM

GABRB2 AP2M1 KCNMB3 CASK

1.07e-02411304M735
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

CACNA1F CACNA1S

1.08e-0274302M48080
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

CACNA1F CACNA1S

1.08e-0274302M39462
PathwayWP_ALZHEIMERS_DISEASE

CACNA1F CACNA1S

1.08e-0274302MM15962
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

CACNA1F CACNA1S

1.08e-0274302M16376
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

2.19e-0834032711875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

2.19e-0834032711802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

2.32e-0834332732295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6 OR4L1

2.47e-0834632714611657
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

FZD1 FZD2 FZD3

3.95e-08832319388021
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR1F1 OR7D4 OR1A2 OR8J3 OR2A5 OR2T6

4.60e-0821932612213199
Pubmed

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

FZD1 FZD2 FZD3

8.45e-081032317532316
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD1 FZD2 FZD3

8.45e-081032315245425
Pubmed

Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

FZD1 FZD2 FZD3

1.16e-071132330978219
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD1 FZD2 FZD3

1.16e-071132324860427
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD1 FZD2 FZD3

1.16e-071132317582687
Pubmed

Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.

FZD1 FZD2 FZD3

1.16e-071132325294940
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD1 FZD2 FZD3

1.16e-071132317576136
Pubmed

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

FZD1 FZD2 FZD3

6.79e-071932321623369
Pubmed

Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation.

AQP7P3 AQP7

8.20e-07232223290745
Pubmed

Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice.

AQP7P3 AQP7

8.20e-07232217123523
Pubmed

Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.

AQP7P3 AQP7

8.20e-07232211972053
Pubmed

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.

FZD1 FZD2

8.20e-07232220189955
Pubmed

Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.

AQP7P3 AQP7

8.20e-07232215591341
Pubmed

Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.

AQP7P3 AQP7

8.20e-07232237432580
Pubmed

Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.

AQP7P3 AQP7

8.20e-07232217576812
Pubmed

Over-expression of AQP7 contributes to improve insulin resistance in adipocytes.

AQP7P3 AQP7

8.20e-07232222877989
Pubmed

Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.

AQP7P3 AQP7

8.20e-07232215746100
Pubmed

Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.

AQP7P3 AQP7

8.20e-07232232631905
Pubmed

Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation.

AQP7P3 AQP7

8.20e-07232226634435
Pubmed

Human ABC transporters ABCG2 (BCRP) and ABCG4.

ABCG4 ABCG2

8.20e-07232218668433
Pubmed

Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization.

AQP7P3 AQP7

8.20e-07232221130427
Pubmed

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier.

ABCG4 ABCG2

8.20e-07232222391220
Pubmed

Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.

AQP7P3 AQP7

8.20e-07232211457862
Pubmed

The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator.

AQP7P3 AQP7

8.20e-07232219297367
Pubmed

AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism.

AQP7P3 AQP7

8.20e-07232217077387
Pubmed

Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice.

AQP7P3 AQP7

8.20e-07232237691043
Pubmed

Dynamic subcellular localization of aquaporin-7 in white adipocytes.

AQP7P3 AQP7

8.20e-07232225643985
Pubmed

Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells.

AQP7P3 AQP7

8.20e-07232237879294
Pubmed

Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping.

AQP7P3 AQP7

8.20e-0723229714739
Pubmed

Aquaporin7 expression during perinatal development of mouse brain.

AQP7P3 AQP7

8.20e-07232217052846
Pubmed

Prolonged Starvation Causes Up-Regulation of AQP1 in Adipose Tissue Capillaries of AQP7 Knock-Out Mice.

AQP7P3 AQP7

8.20e-07232227455244
Pubmed

Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells.

AQP7P3 AQP7

8.20e-07232221968069
Pubmed

A new role for aquaporin 7 in insulin secretion.

AQP7P3 AQP7

8.20e-07232222415076
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD1 FZD2 FZD3

1.08e-062232317064353
Pubmed

A role for Wnt/beta-catenin signaling in lens epithelial differentiation.

FZD1 FZD2 FZD3

1.60e-062532312812787
Pubmed

Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.

AQP7P3 AQP7

2.46e-06332212351427
Pubmed

Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes.

AQP7P3 AQP7

2.46e-06332220573496
Pubmed

Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

FZD1 FZD2

2.46e-0633229813155
Pubmed

Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.

AQP7P3 AQP7

2.46e-06332215998844
Pubmed

Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.

AQP7P3 AQP7

2.46e-06332216009937
Pubmed

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

FZD1 FZD2

2.46e-06332227680706
Pubmed

Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle.

AQP7P3 AQP7

2.46e-06332227746040
Pubmed

Adipocyte lipolysis drives acute stress-induced insulin resistance.

AQP7P3 AQP7

2.46e-06332233097799
Pubmed

Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.

AQP7P3 AQP7

2.46e-06332238064372
Pubmed

Channel-dependent permeation of water and glycerol in mouse morulae.

AQP7P3 AQP7

2.46e-06332216339044
Pubmed

Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa.

AQP7P3 AQP7

2.46e-06332218829704
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

FZD1 FZD2 FZD3

2.54e-062932318364260
Pubmed

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.

FZD1 FZD2

4.92e-06432218929644
Pubmed

LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.

AQP7P3 AQP7

4.92e-06432234807469
Pubmed

The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles.

AQP7P3 AQP7

4.92e-06432219005169
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1F CACNA1S

4.92e-06432220937870
Pubmed

Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus.

AQP7P3 AQP7

4.92e-06432229890131
Pubmed

Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.

AQP7P3 AQP7

4.92e-06432217245390
Pubmed

Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.

AQP7P3 AQP7

4.92e-06432211952783
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD1 FZD2 FZD3

4.95e-063632324151333
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

FZD1 FZD2 FZD3

5.38e-063732315342465
Pubmed

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.

FZD1 FZD2 FZD3

5.38e-063732318800919
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

FZD1 FZD2 FZD3

5.84e-063832318635608
Pubmed

Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.

FZD1 FZD2 FZD3

5.84e-063832321041481
Pubmed

Temporal/spatial expression and efflux activity of ABC transporter, P-glycoprotein/Abcb1 isoforms and Bcrp/Abcg2 during early murine development.

ABCG4 ABCG2

8.19e-06532216458078
Pubmed

Expression and functional characterization of ABCG1 splice variant ABCG1(666).

ABCG4 ABCG2

8.19e-06532216870176
Pubmed

More than just water channels: unexpected cellular roles of aquaporins.

AQP7P3 AQP7

8.19e-06532216079275
Pubmed

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

FZD1 FZD2 FZD3

1.12e-054732328813421
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

FZD1 FZD2 FZD3

1.12e-054732333141892
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

FZD1 FZD2 FZD3

1.12e-054732318351675
Pubmed

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.

FZD2 FZD3

1.23e-05632220802536
Pubmed

Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.

AQP7P3 AQP7

1.23e-05632212351183
Pubmed

FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways.

FZD1 FZD2

1.23e-05632236867021
Pubmed

Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.

FZD1 FZD2 FZD3

1.27e-054932319562671
Pubmed

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.

FZD1 FZD2 FZD3

1.35e-055032318351662
Pubmed

Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.

FZD1 FZD2 FZD3

1.35e-055032327510977
Pubmed

Role of aquaporin water channels in kidney and lung.

AQP7P3 AQP7

1.72e-0573229822113
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1F CACNA1S

1.72e-05732212900400
Pubmed

Lessons on renal physiology from transgenic mice lacking aquaporin water channels.

AQP7P3 AQP7

1.72e-05732210232700
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1F CACNA1S

2.29e-05832228330839
Pubmed

A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence.

GABRB2 SLC12A5

2.29e-05832227540587
Pubmed

Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.

FZD1 FZD3

2.29e-05832210559494
Pubmed

Aquaporin molecular biology and clinical abnormalities of the water transport channels.

AQP7P3 AQP7

2.94e-0593229757370
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1F CACNA1S

2.94e-05932216382099
Pubmed

Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.

FZD1 FZD2

2.94e-05932212067714
Pubmed

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.

FZD2 FZD3

2.94e-05932219038973
Pubmed

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

FZD1 FZD2

2.94e-0593229707618
Pubmed

Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.

FZD1 FZD2

2.94e-05932223095888
Pubmed

Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea.

AQP7P3 AQP7

3.67e-051032212031518
Pubmed

mRNAs encoding aquaporins are present during murine preimplantation development.

AQP7P3 AQP7

3.67e-051032211066060
Pubmed

Expression of mRNAs of the aquaporin family in mouse oocytes and embryos.

AQP7P3 AQP7

3.67e-051032210788316
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR1A2 OR8J3 OR4L1

4.39e-057432315081110
Pubmed

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.

GABRB2 SLC12A5

4.49e-051132238894703
Pubmed

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.

FZD1 FZD2

6.36e-051332221246654
Pubmed

Tbx6 controls left-right asymmetry through regulation of Gdf1.

FZD2 FZD3

6.36e-051332229650695
Pubmed

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

FZD1 FZD2 FZD3

7.87e-059032319515997
Pubmed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.

FZD2 FZD3

8.55e-051532215617677
Pubmed

Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.

AQP7P3 AQP7

8.55e-051532234540996
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1F CACNA1S

8.55e-051532220188150
InteractionP2RY1 interactions

PTDSS2 FZD2 TMEM87A

3.28e-0545283int:P2RY1
InteractionUPK1A interactions

FZD1 FZD2 FZD3 TMEM87A

5.25e-05150284int:UPK1A
Cytoband11p15.5

SLC22A18 ANO9 PTDSS2

7.77e-0511832311p15.5
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD1 FZD2 FZD3

3.37e-0711243286
GeneFamilyBlood group antigens|CD molecules|ATP binding cassette subfamily G

ABCG4 ABCG2

1.68e-055242811
GeneFamilyCalcium voltage-gated channel subunits

CACNA1F CACNA1S

5.38e-0426242253
GeneFamilyOlfactory receptors, family 1

OR1F1 OR1A2

1.28e-0340242147
GeneFamilyOlfactory receptors, family 2

OR2A5 OR2T6

9.77e-03113242149
GeneFamilySolute carriers

SLC22A18 SLC28A3 SLC12A5

1.49e-02395243752
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GABRB2 ABCG4 OCA2 SLC12A5

1.09e-052003142f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GABRB2 ABCG4 OCA2 SLC12A5

1.09e-05200314dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GABRB2 ABCG4 OCA2 SLC12A5

1.09e-05200314bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCellP07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ABCG4 SLC22A18 FZD2

1.62e-041533135501095bcf73080872ae01128f21399f9cfc5dd1
ToppCelldroplet-Liver-Npc-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDS1 FZD3 AQP7

1.68e-041553135d600e159738231d0607ea1a1ebd8510fc241b36
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F CDS1 CASK

2.20e-04170313ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F CDS1 CASK

2.20e-04170313a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellileum|World / shred on tissue and cell subclass

SLC22A18 ABCG2 AQP7

2.20e-041703139f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCelldroplet-Fat-SCAT-30m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG2 AQP7 SLC12A5

2.32e-04173313eb58b0189e71e38d4f4f1cf544a82cde8d1c86bc
ToppCellfacs-Marrow-T_cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S TMEM248 AVPR1A

2.32e-04173313e0cf99ddbe6e9eab05d7bf89e9aa124850c6a807
ToppCellfacs-Marrow-T_cells-18m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S TMEM248 AVPR1A

2.40e-041753134be01bf30331162f1998216fb2871a4e626dc440
ToppCelldroplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A18 CACNA1S PTDSS2

2.44e-0417631324b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC22A18 CACNA1S PTDSS2

2.48e-04177313f360f7099570d248531897b96e0de282e58f59e9
ToppCelldroplet-Spleen-SPLEEN-30m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

2.87e-04186313ac6e32cf07f0f013101ca7aedae0c562857f182b
ToppCelldroplet-Spleen-SPLEEN-30m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

2.87e-041863137cdcf507a9a1349ed2cf62b79116367c3fc732dd
ToppCelldroplet-Spleen-SPLEEN-30m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

2.92e-04187313dceca7ae3dae96078cccc17a0d8a61b06fa6dffb
ToppCelldroplet-Marrow-BM-30m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

2.96e-04188313f1a9d8ea174a4bef0fae8188e3bd96b7ac1a39bb
ToppCelldroplet-Marrow-nan-24m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

3.01e-0418931398ace332c3c046694c6ade47de8c8bf57ec51271
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

3.01e-041893133ade3fa9369e85304b20d7233b581f18ad5ecc89
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

3.01e-0418931316dfc37d8d390ed7f927bc844c47c9c5a89a0928
ToppCelldroplet-Marrow-nan-3m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

3.01e-041893138a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCelldroplet-Spleen-nan-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

3.05e-04190313a273fc119baebc11020009c923beafeebb6428c9
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

3.10e-0419131324ebc8d4a9fc3782510162e04fe586f7cb371eed
ToppCelldroplet-Marrow-BM-1m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCG4 PTDSS2 ABCG2

3.10e-04191313d78d4fbb0b8317dbf14e32182466a432abef3e93
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 FZD2 FZD3

3.20e-04193313eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCell356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

FZD1 FZD2 SLC12A5

3.25e-0419431311ff53a748160570d2908ea9eb9779c038e5b676
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 FZD2 FZD3

3.25e-041943135d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCellfacs-Skin-Telogen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 FZD2 FZD3

3.34e-04196313c936014125b2ed5f796221b74acb77b8f8359875
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

CACNA1F SLC28A3 CDS1

3.40e-041973131a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLC28A3 CDS1 TMEM87A

3.40e-041973131485933986921ff45669d9b7501c8d17050b3e97
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNA1F SLC28A3 CDS1

3.45e-04198313285f729140b1df029c24f6ca1d2438470ac51794
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AQP7B SLC22A18 ABCG2

3.45e-041983138fac96132663f54566136ef54b53684d31dfde32
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AQP7B SLC22A18 ABCG2

3.45e-04198313c48b3f026b16d48b8eca9f74dc1e3f3f39a89322
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-Treg|Influenza_Severe / Disease, condition lineage and cell class

CACNA1F ANO9 CASK

3.45e-04198313e377fa0215f338f86ee2903ce3fa57cea805a630
ToppCell10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FZD1 ABCG4 AQP7B

3.50e-041993136200618e029063486719479c41eaf31798bd13cf
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1F CACNA1S

5.59e-064292DOID:0060173 (implicated_via_orthology)
Diseasebreast carcinoma (is_marker_for)

FZD1 ABCG2 FZD2

3.75e-0566293DOID:3459 (is_marker_for)
DiseaseMammary Neoplasms, Experimental

CDS1 ABCG2 CASK

4.70e-04155293C0024668
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1F CACNA1S

5.76e-0436292DOID:11723 (implicated_via_orthology)
DiseaseSchizophrenia

GABRB2 CACNA1F AVPR1A FZD3 SLC12A5

1.55e-03883295C0036341

Protein segments in the cluster

PeptideGeneStartEntry
CLFFSMLFLMFAALM

ABCG4

426

Q9H172
MISLFFLIIYMGSFM

CDS1

96

Q92903
FFVMMFTLMMVAYSA

ABCG2

506

Q9UNQ0
FMEMMIQYGFTTIFV

ANO9

541

A1A5B4
FMEFFRLGFPMMVVS

OCA2

806

Q04671
MIFFIYAVIGMQMFG

CACNA1F

1336

O60840
MLYMVFEFMDGADLC

CASK

86

O14936
FISFGGCLMQMYFMI

OR1A2

91

Q9Y585
EFLAEFMSTYVMMVF

AQP7P3

36

A6NL99
FLAEFMSTYVMMVFG

AQP7B

41

A0A075B734
FFFGVICAVFFMAMI

OR2T6

26

Q8NHC8
MFFMHFFGGAEMTLL

OR4L1

101

Q8NH43
GCTILFMMLYFFSMA

FZD2

326

Q14332
DMYLMGCFVFVFMAL

GABRB2

306

P47870
YFMIGGMLLTCVVMF

GOSR2

191

O14653
EFLAEFMSTYVMMVF

AQP7

36

O14520
AMVFEFLYKMCDVMA

AP2M1

76

Q96CW1
FFIVSEVMMLAVMAY

OR8J3

106

Q8NGG0
GCLTQMYFVFMFVDM

OR1F1

96

O43749
MYFVFMFVDMDNFLL

OR1F1

101

O43749
CMVGLFFGSAIVMYM

OR2A5

246

Q96R48
GCLTQVYFLMMFAGM

OR7D4

96

Q8NG98
VYFLMMFAGMDTFLL

OR7D4

101

Q8NG98
MFAGMDTFLLAVMAY

OR7D4

106

Q8NG98
GCTILFMMLYFFSMA

FZD1

401

Q9UP38
MLFFIYAVIGMQMFG

CACNA1S

1276

Q13698
CTMLFMILYFFTMAG

FZD3

286

Q9NPG1
LGFAMMGFSVLMFFL

KCNMB3

61

Q9NPA1
APILSMFFLMCYMFV

SLC12A5

581

Q9H2X9
MHTSYFLFVMVITMF

TMEM248

271

Q9NWD8
MCMIISVMFEFLEYS

PTDSS2

216

Q9BVG9
CSYIFMPFSFMMGVE

SLC28A3

486

Q9HAS3
LFMVMFSIISMDFFQ

SLC22A18

256

Q96BI1
QVFGMFASAYMLVVM

AVPR1A

131

P37288
LMIFFMVMCIVYVLF

TMEM87A

226

Q8NBN3