Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	insulin-like growth factor receptor binding	INS INS-IGF2	4.75e-04	18	36	2	GO:0005159
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activator activity	INS INS-IGF2	7.14e-04	22	36	2	GO:0030297
GeneOntologyMolecularFunction	insulin receptor binding	INS INS-IGF2	1.33e-03	30	36	2	GO:0005158
GeneOntologyMolecularFunction	protein tyrosine kinase activator activity	INS INS-IGF2	1.92e-03	36	36	2	GO:0030296
GeneOntologyBiologicalProcess	negative regulation of NAD(P)H oxidase activity	INS INS-IGF2	9.90e-06	3	38	2	GO:0033861
GeneOntologyBiologicalProcess	negative regulation of glycogen catabolic process	INS INS-IGF2	1.98e-05	4	38	2	GO:0045818
GeneOntologyBiologicalProcess	positive regulation of nitric oxide mediated signal transduction	INS INS-IGF2	1.98e-05	4	38	2	GO:0010750
GeneOntologyBiologicalProcess	positive regulation of lipid kinase activity	INS INS-IGF2	3.29e-05	5	38	2	GO:0090218
GeneOntologyBiologicalProcess	negative regulation of respiratory burst involved in inflammatory response	INS INS-IGF2	4.93e-05	6	38	2	GO:0060266
GeneOntologyBiologicalProcess	regulation of NAD(P)H oxidase activity	INS INS-IGF2	4.93e-05	6	38	2	GO:0033860
GeneOntologyBiologicalProcess	positive regulation of dendritic spine maintenance	INS INS-IGF2	6.90e-05	7	38	2	GO:1902952
GeneOntologyBiologicalProcess	negative regulation of respiratory burst	INS INS-IGF2	9.19e-05	8	38	2	GO:0060268
GeneOntologyBiologicalProcess	positive regulation of respiratory burst	INS INS-IGF2	1.47e-04	10	38	2	GO:0060267
GeneOntologyBiologicalProcess	nitric oxide-cGMP-mediated signaling	INS INS-IGF2	1.80e-04	11	38	2	GO:0038060
GeneOntologyBiologicalProcess	regulation of lipid kinase activity	INS INS-IGF2	1.80e-04	11	38	2	GO:0043550
GeneOntologyBiologicalProcess	regulation of respiratory burst involved in inflammatory response	INS INS-IGF2	1.80e-04	11	38	2	GO:0060264
GeneOntologyBiologicalProcess	insulin processing	INS INS-IGF2	2.16e-04	12	38	2	GO:0030070
GeneOntologyBiologicalProcess	neuron projection maintenance	INS INS-IGF2	2.55e-04	13	38	2	GO:1990535
GeneOntologyBiologicalProcess	respiratory burst involved in inflammatory response	INS INS-IGF2	2.55e-04	13	38	2	GO:0002536
GeneOntologyBiologicalProcess	regulation of glycogen catabolic process	INS INS-IGF2	2.97e-04	14	38	2	GO:0005981
GeneOntologyBiologicalProcess	regulation of nitric oxide mediated signal transduction	INS INS-IGF2	2.97e-04	14	38	2	GO:0010749
GeneOntologyBiologicalProcess	ER overload response	INS INS-IGF2	3.42e-04	15	38	2	GO:0006983
GeneOntologyBiologicalProcess	actin crosslink formation	LCP1 GAS2	3.90e-04	16	38	2	GO:0051764
GeneOntologyBiologicalProcess	negative regulation of glycogen metabolic process	INS INS-IGF2	3.90e-04	16	38	2	GO:0070874
GeneOntologyBiologicalProcess	chaperone-mediated autophagy	ATG7 PLK3	4.42e-04	17	38	2	GO:0061684
GeneOntologyBiologicalProcess	positive regulation of glycogen biosynthetic process	INS INS-IGF2	4.96e-04	18	38	2	GO:0045725
GeneOntologyBiologicalProcess	regulation of dendritic spine maintenance	INS INS-IGF2	4.96e-04	18	38	2	GO:1902950
GeneOntologyBiologicalProcess	negative regulation of acute inflammatory response	INS INS-IGF2	4.96e-04	18	38	2	GO:0002674
GeneOntologyBiologicalProcess	regulation of amino acid metabolic process	INS INS-IGF2	4.96e-04	18	38	2	GO:0006521
GeneOntologyBiologicalProcess	fatty acid homeostasis	INS INS-IGF2	4.96e-04	18	38	2	GO:0055089
GeneOntologyBiologicalProcess	respiratory burst involved in defense response	INS INS-IGF2	6.15e-04	20	38	2	GO:0002679
GeneOntologyBiologicalProcess	regulation of respiratory burst	INS INS-IGF2	8.16e-04	23	38	2	GO:0060263
GeneOntologyBiologicalProcess	production of molecular mediator of immune response	IGKV3D-15 IGKV3D-11 SLAMF9 IGKV3-15 IGKV3-7	8.20e-04	403	38	5	GO:0002440
GeneOntologyBiologicalProcess	D-glucose import	INS SLC2A1 INS-IGF2	8.73e-04	102	38	3	GO:0046323
GeneOntologyBiologicalProcess	positive regulation of glycogen metabolic process	INS INS-IGF2	8.89e-04	24	38	2	GO:0070875
GeneOntologyBiologicalProcess	activation of protein kinase B activity	INS INS-IGF2	9.65e-04	25	38	2	GO:0032148
GeneOntologyBiologicalProcess	immunoglobulin production	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-7	9.82e-04	241	38	4	GO:0002377
GeneOntologyBiologicalProcess	negative regulation of reactive oxygen species biosynthetic process	INS INS-IGF2	1.30e-03	29	38	2	GO:1903427
GeneOntologyBiologicalProcess	positive regulation of glycolytic process	INS INS-IGF2	1.30e-03	29	38	2	GO:0045821
GeneOntologyBiologicalProcess	positive regulation of purine nucleotide catabolic process	INS INS-IGF2	1.30e-03	29	38	2	GO:0033123
GeneOntologyBiologicalProcess	positive regulation of nucleotide catabolic process	INS INS-IGF2	1.30e-03	29	38	2	GO:0030813
GeneOntologyBiologicalProcess	negative regulation of oxidoreductase activity	INS INS-IGF2	1.30e-03	29	38	2	GO:0051354
GeneOntologyBiologicalProcess	dendritic spine maintenance	INS INS-IGF2	1.39e-03	30	38	2	GO:0097062
GeneOntologyBiologicalProcess	positive regulation of insulin receptor signaling pathway	INS INS-IGF2	1.58e-03	32	38	2	GO:0046628
GeneOntologyBiologicalProcess	negative regulation of feeding behavior	INS INS-IGF2	1.68e-03	33	38	2	GO:2000252
GeneOntologyBiologicalProcess	negative regulation of lipid catabolic process	INS INS-IGF2	1.79e-03	34	38	2	GO:0050995
GeneOntologyBiologicalProcess	glycogen catabolic process	INS INS-IGF2	1.89e-03	35	38	2	GO:0005980
GeneOntologyBiologicalProcess	insulin metabolic process	INS INS-IGF2	1.89e-03	35	38	2	GO:1901142
GeneOntologyCellularComponent	IgM immunoglobulin complex, circulating	IGKV3D-15 IGKV3D-11 IGKV3-15	3.34e-07	8	39	3	GO:0071754
GeneOntologyCellularComponent	pentameric IgM immunoglobulin complex	IGKV3D-15 IGKV3D-11 IGKV3-15	3.34e-07	8	39	3	GO:0071756
GeneOntologyCellularComponent	monomeric IgA immunoglobulin complex	IGKV3D-15 IGKV3D-11 IGKV3-15	5.00e-07	9	39	3	GO:0071748
GeneOntologyCellularComponent	polymeric IgA immunoglobulin complex	IGKV3D-15 IGKV3D-11 IGKV3-15	7.14e-07	10	39	3	GO:0071749
GeneOntologyCellularComponent	IgA immunoglobulin complex, circulating	IGKV3D-15 IGKV3D-11 IGKV3-15	7.14e-07	10	39	3	GO:0071746
GeneOntologyCellularComponent	secretory IgA immunoglobulin complex	IGKV3D-15 IGKV3D-11 IGKV3-15	7.14e-07	10	39	3	GO:0071751
GeneOntologyCellularComponent	IgA immunoglobulin complex	IGKV3D-15 IGKV3D-11 IGKV3-15	2.69e-06	15	39	3	GO:0071745
GeneOntologyCellularComponent	IgM immunoglobulin complex	IGKV3D-15 IGKV3D-11 IGKV3-15	2.69e-06	15	39	3	GO:0071753
GeneOntologyCellularComponent	immunoglobulin complex, circulating	IGKV3D-15 IGKV3D-11 IGKV3-15	4.01e-06	17	39	3	GO:0042571
GeneOntologyCellularComponent	immunoglobulin complex	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-7	2.54e-04	166	39	4	GO:0019814
GeneOntologyCellularComponent	sno(s)RNA-containing ribonucleoprotein complex	INS INS-IGF2	1.62e-03	32	39	2	GO:0005732
GeneOntologyCellularComponent	secretory vesicle	SFTPA1 SLC2A13 KLK10 ATG7 TRPM7 INS INS-IGF2 AGPAT2	1.83e-03	1246	39	8	GO:0099503
GeneOntologyCellularComponent	glial cell projection	SLC2A13 LCP1	3.48e-03	47	39	2	GO:0097386
MousePheno	decreased cellular glucose uptake	RALGAPA1 INS SLC2A1 INS-IGF2	3.52e-06	53	28	4	MP:0003926
MousePheno	increased pancreatic beta cell number	INS INS-IGF2 AGPAT2	3.96e-06	16	28	3	MP:0003645
MousePheno	increased pancreatic beta cell mass	INS INS-IGF2 AGPAT2	6.83e-06	19	28	3	MP:0009113
MousePheno	abnormal pancreatic islet size	TNK1 INS INS-IGF2 AGPAT2	2.80e-05	89	28	4	MP:0009170
MousePheno	abnormal cellular glucose uptake	RALGAPA1 INS SLC2A1 INS-IGF2	4.78e-05	102	28	4	MP:0003925
MousePheno	polydipsia	INS INS-IGF2 AGPAT2	5.34e-05	37	28	3	MP:0001426
MousePheno	increased anti-insulin autoantibody level	INS INS-IGF2	5.77e-05	6	28	2	MP:0002869
MousePheno	degranulated pancreatic beta cells	INS INS-IGF2	5.77e-05	6	28	2	MP:0009255
MousePheno	increased carbon dioxide production	INS INS-IGF2 AGPAT2	5.79e-05	38	28	3	MP:0008963
MousePheno	decreased muscle cell glucose uptake	RALGAPA1 INS INS-IGF2	6.27e-05	39	28	3	MP:0030022
MousePheno	increased renal glomerular filtration rate	INS INS-IGF2	1.08e-04	8	28	2	MP:0005527
MousePheno	abnormal pancreatic beta cell mass	INS INS-IGF2 AGPAT2	1.10e-04	47	28	3	MP:0009112
MousePheno	decreased skeletal muscle triglyceride level	INS INS-IGF2	1.38e-04	9	28	2	MP:0031414
MousePheno	absent pancreatic beta cells	INS INS-IGF2	1.38e-04	9	28	2	MP:0009174
MousePheno	abnormal pancreatic beta cell number	INS INS-IGF2 AGPAT2	1.67e-04	54	28	3	MP:0020578
MousePheno	abnormal muscle cell glucose uptake	RALGAPA1 INS INS-IGF2	3.16e-04	67	28	3	MP:0004130
MousePheno	abnormal carbon dioxide production	INS INS-IGF2 AGPAT2	3.16e-04	67	28	3	MP:0008962
MousePheno	increased pancreatic islet cell apoptosis	INS INS-IGF2	3.47e-04	14	28	2	MP:0014121
MousePheno	abnormal kidney vasculature morphology	PTGIS INS INS-IGF2	4.08e-04	73	28	3	MP:0000530
MousePheno	disorganized pancreatic islets	INS INS-IGF2	4.56e-04	16	28	2	MP:0009254
MousePheno	abnormal pancreatic islet cell apoptosis	INS INS-IGF2	5.16e-04	17	28	2	MP:0009488
MousePheno	abnormal pancreatic islet morphology	TNK1 INS INS-IGF2 AGPAT2	5.24e-04	190	28	4	MP:0005215
MousePheno	abnormal liver triglyceride level	RALGAPA1 INS INS-IGF2 AGPAT2	5.35e-04	191	28	4	MP:0012778
MousePheno	abnormal endocrine pancreas morphology	TNK1 INS INS-IGF2 AGPAT2	5.35e-04	191	28	4	MP:0009165
MousePheno	insulin resistance	RALGAPA1 INS INS-IGF2 AGPAT2	6.01e-04	197	28	4	MP:0005331
MousePheno	decreased pancreatic alpha cell number	INS INS-IGF2	6.48e-04	19	28	2	MP:0009177
MousePheno	increased susceptibility to autoimmune diabetes	INS INS-IGF2	6.48e-04	19	28	2	MP:0004803
MousePheno	increased pancreatic alpha cell number	INS INS-IGF2	7.19e-04	20	28	2	MP:0009176
MousePheno	decreased adipocyte glucose uptake	INS INS-IGF2	7.19e-04	20	28	2	MP:0030017
MousePheno	akinesia	INS INS-IGF2	7.94e-04	21	28	2	MP:0002690
MousePheno	hematoma	INS INS-IGF2	1.04e-03	24	28	2	MP:0008817
MousePheno	increased adipocyte glucose uptake	INS INS-IGF2	1.04e-03	24	28	2	MP:0030016
MousePheno	abnormal renal glomerular filtration rate	INS INS-IGF2	1.13e-03	25	28	2	MP:0002847
MousePheno	increased fluid intake	INS INS-IGF2 AGPAT2	1.14e-03	104	28	3	MP:0011941
MousePheno	hyperglycemia	INS INS-IGF2 AGPAT2	1.18e-03	105	28	3	MP:0001559
MousePheno	insulitis	INS INS-IGF2	1.22e-03	26	28	2	MP:0004031
MousePheno	hydronephrosis	HTR3A INS INS-IGF2	1.31e-03	109	28	3	MP:0000519
MousePheno	increased renal glomerulus basement membrane thickness	INS INS-IGF2	1.32e-03	27	28	2	MP:0011409
MousePheno	decreased respiratory quotient	INS INS-IGF2 AGPAT2	1.35e-03	110	28	3	MP:0010379
MousePheno	decreased insulin secretion	RNF213 INS INS-IGF2	1.38e-03	111	28	3	MP:0003059
MousePheno	abnormal renal glomerular filtration	INS INS-IGF2	1.52e-03	29	28	2	MP:0013284
MousePheno	abnormal pancreatic beta cell morphology	INS INS-IGF2 AGPAT2	1.53e-03	115	28	3	MP:0005217
MousePheno	increased urine glucose level	INS INS-IGF2	1.63e-03	30	28	2	MP:0001759
MousePheno	decreased circulating leptin level	INS INS-IGF2 AGPAT2	1.65e-03	118	28	3	MP:0005668
MousePheno	abnormal skeletal muscle triglyceride level	INS INS-IGF2	1.74e-03	31	28	2	MP:0031413
MousePheno	abnormal renal glomerulus basement membrane thickness	INS INS-IGF2	1.74e-03	31	28	2	MP:0011349
MousePheno	increased oxygen consumption	INS INS-IGF2 AGPAT2	1.77e-03	121	28	3	MP:0005289
MousePheno	decreased pancreatic beta cell mass	INS INS-IGF2	1.85e-03	32	28	2	MP:0009114
MousePheno	no spontaneous movement	ADGB ATG7 AGPAT2	1.85e-03	123	28	3	MP:0001404
MousePheno	abnormal subcutaneous adipose tissue amount	INS INS-IGF2 AGPAT2	1.90e-03	124	28	3	MP:0020997
MousePheno	abnormal kidney pelvis morphology	HTR3A INS INS-IGF2	1.90e-03	124	28	3	MP:0004194
MousePheno	thick interventricular septum	INS INS-IGF2	1.97e-03	33	28	2	MP:0010724
MousePheno	abnormal hypodermis fat layer morphology	INS INS-IGF2 AGPAT2	1.99e-03	126	28	3	MP:0011156
MousePheno	abnormal adipose tissue physiology	INS INS-IGF2 AGPAT2	2.03e-03	127	28	3	MP:0005666
MousePheno	abnormal urine glucose level	INS INS-IGF2	2.09e-03	34	28	2	MP:0001758
MousePheno	decreased skeletal muscle cell glucose uptake	INS INS-IGF2	2.21e-03	35	28	2	MP:0031618
MousePheno	abnormal pancreatic alpha cell number	INS INS-IGF2	2.21e-03	35	28	2	MP:0020577
MousePheno	abnormal muscle triglyceride level	INS INS-IGF2	2.34e-03	36	28	2	MP:0031412
MousePheno	impaired glucose tolerance	SLC2A13 DPP8 SLC22A16 INS INS-IGF2	2.39e-03	480	28	5	MP:0005293
MousePheno	abnormal fluid intake	INS INS-IGF2 AGPAT2	2.47e-03	136	28	3	MP:0011947
MousePheno	increased circulating ketone body level	INS INS-IGF2	2.74e-03	39	28	2	MP:0002575
MousePheno	decreased pancreatic beta cell number	INS INS-IGF2	3.02e-03	41	28	2	MP:0003339
MousePheno	abnormal urination	HTR3A INS INS-IGF2	3.14e-03	148	28	3	MP:0001756
MousePheno	renal glomerular protein deposits	INS INS-IGF2	3.17e-03	42	28	2	MP:0020518
MousePheno	abnormal adipocyte glucose uptake	INS INS-IGF2	3.17e-03	42	28	2	MP:0004185
MousePheno	increased urine protein level	HTR3A INS INS-IGF2	3.20e-03	149	28	3	MP:0002962
MousePheno	ketosis	INS INS-IGF2	3.32e-03	43	28	2	MP:0030970
MousePheno	abnormal renal glomerulus basement membrane morphology	INS INS-IGF2	3.47e-03	44	28	2	MP:0011348
MousePheno	increased retina apoptosis	INS INS-IGF2	3.63e-03	45	28	2	MP:0030005
MousePheno	decreased susceptibility to autoimmune diabetes	INS INS-IGF2	3.63e-03	45	28	2	MP:0004804
MousePheno	small pancreatic islets	INS INS-IGF2	3.79e-03	46	28	2	MP:0009172
MousePheno	abnormal pancreatic alpha cell morphology	INS INS-IGF2	3.79e-03	46	28	2	MP:0005216
MousePheno	decreased body fat mass	INS INS-IGF2	3.79e-03	46	28	2	MP:0014143
MousePheno	increased vascular permeability	INS INS-IGF2	3.79e-03	46	28	2	MP:0003070
MousePheno	expanded mesangial matrix	INS INS-IGF2	3.79e-03	46	28	2	MP:0011353
MousePheno	abnormal drinking behavior	INS INS-IGF2 AGPAT2	3.84e-03	159	28	3	MP:0001422
MousePheno	abnormal skeletal muscle cell glucose uptake	INS INS-IGF2	3.96e-03	47	28	2	MP:0031617
MousePheno	enlarged pancreatic islets	TNK1 AGPAT2	3.96e-03	47	28	2	MP:0009171
MousePheno	abnormal glomerular capillary morphology	INS INS-IGF2	3.96e-03	47	28	2	MP:0011320
Domain	Sugar_tr	SLC2A13 SLC22A16 SLC2A1	3.45e-05	36	33	3	PF00083
Domain	MFS_sugar_transport-like	SLC2A13 SLC22A16 SLC2A1	3.45e-05	36	33	3	IPR005828
Domain	MFS_dom	SLC2A13 SLC22A16 SLCO6A1 SLC2A1	8.82e-05	134	33	4	IPR020846
Domain	-	INS INS-IGF2	1.08e-04	9	33	2	1.10.100.10
Domain	Insulin	INS INS-IGF2	1.35e-04	10	33	2	PF00049
Domain	Insulin	INS INS-IGF2	1.65e-04	11	33	2	IPR004825
Domain	IlGF	INS INS-IGF2	1.65e-04	11	33	2	SM00078
Domain	Insulin-like	INS INS-IGF2	1.65e-04	11	33	2	IPR016179
Domain	Sugar/inositol_transpt	SLC2A13 SLC2A1	2.72e-04	14	33	2	IPR003663
Domain	SUGAR_TRANSPORT_2	SLC2A13 SLC2A1	4.05e-04	17	33	2	PS00217
Domain	SUGAR_TRANSPORT_1	SLC2A13 SLC2A1	8.15e-04	24	33	2	PS00216
Domain	MFS	SLC2A13 SLC22A16 SLC2A1	9.04e-04	108	33	3	PS50850
Domain	Sugar_transporter_CS	SLC2A13 SLC2A1	1.45e-03	32	33	2	IPR005829
Domain	CH	LCP1 GAS2	5.87e-03	65	33	2	SM00033
Domain	CH	LCP1 GAS2	6.78e-03	70	33	2	PF00307
Domain	-	LCP1 GAS2	6.97e-03	71	33	2	1.10.418.10
Domain	CH	LCP1 GAS2	7.36e-03	73	33	2	PS50021
Domain	CH-domain	LCP1 GAS2	7.75e-03	75	33	2	IPR001715
Pathway	WP_GLP1_FROM_INTESTINE_AND_PANCREAS_AND_ROLE_IN_GLUCOSE_HOMEOSTASIS	INS SLC2A1	5.27e-05	6	27	2	M48303
Pathway	WP_GLP1_IN_PANCREATIC_ISLET_CELLS	INS SLC2A1	7.38e-05	7	27	2	M48339
Pathway	REACTOME_SIGNAL_ATTENUATION	INS INS-IGF2	1.57e-04	10	27	2	MM15440
Pathway	REACTOME_INSULIN_PROCESSING	INS INS-IGF2	2.72e-04	13	27	2	MM14909
Pathway	WP_CORI_CYCLE	INS SLC2A1	4.72e-04	17	27	2	M39604
Pathway	WP_CONGENITAL_GENERALIZED_LIPODYSTROPHY	INS AGPAT2	5.30e-04	18	27	2	M42546
Pathway	REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN	INS INS-IGF2	6.57e-04	20	27	2	MM15070
Pathway	WP_LEPTININSULIN_SIGNALING_OVERLAP	INS INS-IGF2	6.57e-04	20	27	2	MM15867
Pathway	REACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS	ADCY2 IGKV3-15 IGKV3-11	7.71e-04	95	27	3	M29842
Pathway	WP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH	ATG7 INS	8.72e-04	23	27	2	M39325
Pathway	BIOCARTA_INSULIN_PATHWAY	INS INS-IGF2	9.50e-04	24	27	2	MM1425
Pathway	BIOCARTA_HDAC_PATHWAY	INS INS-IGF2	1.12e-03	26	27	2	MM1371
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ADCY2 INS SLC2A1	1.12e-03	108	27	3	M17034
Pubmed	Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice.	INS INS-IGF2 AGPAT2	1.41e-09	3	40	3	24425876
Pubmed	Ablation of Rnf213 retards progression of diabetes in the Akita mouse.	RNF213 INS INS-IGF2	1.41e-09	3	40	3	23410753
Pubmed	Immunoglobulin genes of different subgroups are interdigitated within the VK locus.	IGKV3D-11 IGKV3-11 IGKV3-7	1.41e-09	3	40	3	6440122
Pubmed	TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation.	TRPM7 INS INS-IGF2	1.41e-09	3	40	3	34345920
Pubmed	The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line.	IGKV3D-15 IGKV3D-11 IGKV3-11 IGKV3-7	3.53e-09	17	40	4	8223863
Pubmed	Integration of ER protein quality control mechanisms defines β cell function and ER architecture.	ATG7 INS INS-IGF2	1.41e-08	5	40	3	36346671
Pubmed	Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis.	INS SLC2A1 INS-IGF2	1.41e-08	5	40	3	35608871
Pubmed	Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes.	IGKV3D-15 IGKV3D-11 IGKV3-15	2.81e-08	6	40	3	98179
Pubmed	Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions.	IGKV3D-15 IGKV3D-11 IGKV3-15	2.81e-08	6	40	3	99744
Pubmed	Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling.	ATG7 INS INS-IGF2	2.81e-08	6	40	3	32182217
Pubmed	Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences.	IGKV3D-15 IGKV3D-11 IGKV3-15	2.81e-08	6	40	3	4691517
Pubmed	The 3' part of the immunoglobulin kappa locus of the mouse.	IGKV3D-15 IGKV3D-11 IGKV3-15	4.92e-08	7	40	3	9603450
Pubmed	The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates.	ATG7 INS INS-IGF2	6.35e-07	15	40	3	32313051
Pubmed	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.	ALDH1A3 INS INS-IGF2	6.35e-07	15	40	3	27572106
Pubmed	m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.	ALDH1A3 INS INS-IGF2	1.14e-06	18	40	3	32404350
Pubmed	Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.	INS INS-IGF2	1.29e-06	2	40	2	9593767
Pubmed	SGLT1/2 inhibition improves glycemic control and multi-organ protection in type 1 diabetes.	INS INS-IGF2	1.29e-06	2	40	2	37520739
Pubmed	Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia.	INS INS-IGF2	1.29e-06	2	40	2	19111542
Pubmed	Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis.	INS INS-IGF2	1.29e-06	2	40	2	35830687
Pubmed	Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes.	INS INS-IGF2	1.29e-06	2	40	2	26733677
Pubmed	Progressive Thinning of Retinal Nerve Fiber Layer/Ganglion Cell Layer (RNFL/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy.	INS INS-IGF2	1.29e-06	2	40	2	37628852
Pubmed	Proinsulin I and II gene expression in inbred mouse strains.	INS INS-IGF2	1.29e-06	2	40	2	2608062
Pubmed	Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling.	INS INS-IGF2	1.29e-06	2	40	2	27335233
Pubmed	Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice.	INS INS-IGF2	1.29e-06	2	40	2	14688305
Pubmed	Bioinformatics Analysis of Weighted Genes in Diabetic Retinopathy.	INS INS-IGF2	1.29e-06	2	40	2	30480744
Pubmed	The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice.	INS INS-IGF2	1.29e-06	2	40	2	34845324
Pubmed	SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.	INS INS-IGF2	1.29e-06	2	40	2	24226524
Pubmed	Genetic control of insulin receptors.	INS INS-IGF2	1.29e-06	2	40	2	7031649
Pubmed	Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.	INS INS-IGF2	1.29e-06	2	40	2	16289958
Pubmed	Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in Akita diabetic mice and restores male fertility.	INS INS-IGF2	1.29e-06	2	40	2	22522616
Pubmed	Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq.	INS INS-IGF2	1.29e-06	2	40	2	27855634
Pubmed	Localization of the rat insulin I gene (INS1) to chromosome 1q55 by fluorescence in situ hybridization.	INS INS-IGF2	1.29e-06	2	40	2	1346376
Pubmed	Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.	INS INS-IGF2	1.29e-06	2	40	2	26203118
Pubmed	Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice.	INS INS-IGF2	1.29e-06	2	40	2	23552863
Pubmed	Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways.	INS INS-IGF2	1.29e-06	2	40	2	27782077
Pubmed	Specific dynamic and noninvasive labeling of pancreatic beta cells in reporter mice.	INS INS-IGF2	1.29e-06	2	40	2	16283623
Pubmed	Type 1 diabetic Akita mice have low bone mass and impaired fracture healing.	INS INS-IGF2	1.29e-06	2	40	2	33662611
Pubmed	Identification of novel diabetes impaired miRNA-transcription factor co-regulatory networks in bone marrow-derived Lin-/VEGF-R2+ endothelial progenitor cells.	INS INS-IGF2	1.29e-06	2	40	2	29995913
Pubmed	Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.	INS INS-IGF2	1.29e-06	2	40	2	15718275
Pubmed	Insulin-Deficient Mouse β-Cells Do Not Fully Mature but Can Be Remedied Through Insulin Replacement by Islet Transplantation.	INS INS-IGF2	1.29e-06	2	40	2	29029025
Pubmed	Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.	INS INS-IGF2	1.29e-06	2	40	2	20948967
Pubmed	Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.	INS INS-IGF2	1.29e-06	2	40	2	20520806
Pubmed	Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas.	INS INS-IGF2	1.29e-06	2	40	2	16799061
Pubmed	Prevalence and Clinical Characteristics of PDX1 Variant Induced Diabetes in Chinese Early-Onset Type 2 Diabetes.	INS INS-IGF2	1.29e-06	2	40	2	37279936
Pubmed	An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages.	INS INS-IGF2	1.29e-06	2	40	2	19778534
Pubmed	Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.	INS INS-IGF2	1.29e-06	2	40	2	26696124
Pubmed	In Vivo Capillary Structure and Blood Cell Flux in the Normal and Diabetic Mouse Eye.	INS INS-IGF2	1.29e-06	2	40	2	35138346
Pubmed	Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets.	INS INS-IGF2	1.29e-06	2	40	2	25686499
Pubmed	Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring.	INS INS-IGF2	1.29e-06	2	40	2	23209676
Pubmed	Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility.	INS INS-IGF2	1.29e-06	2	40	2	27055260
Pubmed	Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells.	INS INS-IGF2	1.29e-06	2	40	2	12059784
Pubmed	Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.	INS INS-IGF2	1.29e-06	2	40	2	19801494
Pubmed	Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice.	INS INS-IGF2	1.29e-06	2	40	2	33667544
Pubmed	Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.	INS INS-IGF2	1.29e-06	2	40	2	7729600
Pubmed	Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.	INS INS-IGF2	1.29e-06	2	40	2	25428948
Pubmed	Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.	INS INS-IGF2	1.29e-06	2	40	2	26595448
Pubmed	Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes.	INS INS-IGF2	1.29e-06	2	40	2	22015457
Pubmed	Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells.	INS INS-IGF2	1.29e-06	2	40	2	30796028
Pubmed	Impact of genetic background on nephropathy in diabetic mice.	INS INS-IGF2	1.29e-06	2	40	2	16118394
Pubmed	High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications.	INS INS-IGF2	1.29e-06	2	40	2	23391566
Pubmed	Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.	INS INS-IGF2	1.29e-06	2	40	2	28700945
Pubmed	Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.	INS INS-IGF2	1.29e-06	2	40	2	23275337
Pubmed	Novel diabetic mouse models as tools for investigating diabetic retinopathy.	INS INS-IGF2	1.29e-06	2	40	2	23251343
Pubmed	The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice.	INS INS-IGF2	1.29e-06	2	40	2	25789863
Pubmed	A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.	INS INS-IGF2	1.29e-06	2	40	2	17151334
Pubmed	Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice.	INS INS-IGF2	1.29e-06	2	40	2	21593201
Pubmed	Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.	INS INS-IGF2	1.29e-06	2	40	2	36170671
Pubmed	Proinsulin maturation disorder is a contributor to the defect of subsequent conversion to insulin in β-cells.	INS INS-IGF2	1.29e-06	2	40	2	21723250
Pubmed	Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes.	INS INS-IGF2	1.29e-06	2	40	2	34675883
Pubmed	The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.	INS INS-IGF2	1.29e-06	2	40	2	15005713
Pubmed	Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?	INS INS-IGF2	1.29e-06	2	40	2	23228931
Pubmed	Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages.	INS INS-IGF2	1.29e-06	2	40	2	23894189
Pubmed	Metabolic effects of short-term caloric restriction in mice with reduced insulin gene dosage.	INS INS-IGF2	1.29e-06	2	40	2	29439088
Pubmed	Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice.	INS INS-IGF2	1.29e-06	2	40	2	22449801
Pubmed	Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice.	INS INS-IGF2	1.29e-06	2	40	2	19874548
Pubmed	The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.	INS INS-IGF2	1.29e-06	2	40	2	29434227
Pubmed	Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy.	INS INS-IGF2	1.29e-06	2	40	2	35234250
Pubmed	Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.	INS INS-IGF2	1.29e-06	2	40	2	16936198
Pubmed	Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.	INS INS-IGF2	1.29e-06	2	40	2	19542201
Pubmed	Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.	INS INS-IGF2	1.29e-06	2	40	2	30019207
Pubmed	Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes.	INS INS-IGF2	1.29e-06	2	40	2	27620487
Pubmed	Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney.	INS INS-IGF2	1.29e-06	2	40	2	31040360
Pubmed	Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.	INS INS-IGF2	1.29e-06	2	40	2	9465295
Pubmed	The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells.	INS INS-IGF2	1.29e-06	2	40	2	15972000
Pubmed	Circulating sphingolipid biomarkers in models of type 1 diabetes.	INS INS-IGF2	1.29e-06	2	40	2	21068007
Pubmed	Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing.	INS INS-IGF2	1.29e-06	2	40	2	28837672
Pubmed	Inducing Specific Immune Tolerance to Prevent Type 1 Diabetes in NOD Mice.	INS INS-IGF2	1.29e-06	2	40	2	26784909
Pubmed	Novel splice variant of mouse insulin2 mRNA: implications for insulin expression.	INS INS-IGF2	1.29e-06	2	40	2	20153322
Pubmed	Noninvasive temporal detection of early retinal vascular changes during diabetes.	INS INS-IGF2	1.29e-06	2	40	2	33060607
Pubmed	Transgenic Expression of miR-133a in the Diabetic Akita Heart Prevents Cardiac Remodeling and Cardiomyopathy.	INS INS-IGF2	1.29e-06	2	40	2	31069235
Pubmed	High fat diet induces brain insulin resistance and cognitive impairment in mice.	INS INS-IGF2	1.29e-06	2	40	2	27771511
Pubmed	Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.	INS INS-IGF2	1.29e-06	2	40	2	26552047
Pubmed	Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes.	INS INS-IGF2	1.29e-06	2	40	2	22915034
Pubmed	Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes.	INS INS-IGF2	1.29e-06	2	40	2	34462258
Pubmed	Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.	INS INS-IGF2	1.29e-06	2	40	2	20825366
Pubmed	Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.	INS INS-IGF2	1.29e-06	2	40	2	19880509
Pubmed	Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.	INS INS-IGF2	1.29e-06	2	40	2	22065673
Pubmed	Increased superoxide contributes to enhancement of vascular contraction in Ins2(Akita) diabetic mice, an autosomal dominant mutant model.	INS INS-IGF2	1.29e-06	2	40	2	18788099
Pubmed	Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice.	INS INS-IGF2	1.29e-06	2	40	2	17459508
Pubmed	Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.	INS INS-IGF2	1.29e-06	2	40	2	15889095
Interaction	AGPAT2 interactions	SLC22A16 INS SLC2A1 AGPAT2	6.07e-06	67	36	4	int:AGPAT2
Cytoband	2p12	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	6.04e-08	117	40	5	2p12
Cytoband	Ensembl 112 genes in cytogenetic band chr2p11	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	1.18e-06	213	40	5	chr2p11
GeneFamily	Immunoglobulin kappa locus at 2p11.2	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	2.35e-07	83	30	5	351
GeneFamily	Solute carriers	SLC2A13 SLC22A16 SLCO6A1 SLC2A1	3.92e-03	395	30	4	752
ToppCell	ICU-SEP-Lymphocyte-B-Plasmablast\|ICU-SEP / Disease, Lineage and Cell Type	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-7 GAS2	3.81e-07	166	40	5	98ce43e14133418f676f1c88c001add9e28259a7
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	3.93e-07	167	40	5	afb6d0993f3fd44a295874673055189d514f7b11
ToppCell	Control-Lymphoid-B_Plasma\|Control / Disease state, Lineage and Cell class	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	4.55e-07	172	40	5	61e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	4.68e-07	173	40	5	7e6bfe85f60834f317941b70d6e0dc3bd527d293
ToppCell	COPD-Lymphoid-B_Plasma\|World / Disease state, Lineage and Cell class	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	4.95e-07	175	40	5	d73ee324479172501481b54967a0f3bd870fcf3a
ToppCell	Control-Lymphoid_P\|Control / Disease group, lineage and cell class	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.10e-07	176	40	5	d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCell	Control-Lymphoid_P-Plasmablast\|Control / Disease group, lineage and cell class	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.10e-07	176	40	5	4b4416f342b732d2cc60133838728880326257d8
ToppCell	IPF-Lymphoid-B_Plasma\|IPF / Disease state, Lineage and Cell class	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.10e-07	176	40	5	e4f33f6cd140dd4fa3002bcd65ac8005d27865d1
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.24e-07	177	40	5	4c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCell	(2)_Plasma_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.24e-07	177	40	5	ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.24e-07	177	40	5	fc40918825b7e1eb6861df59dfca944778a64b98
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.24e-07	177	40	5	d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.54e-07	179	40	5	837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.54e-07	179	40	5	b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	5.85e-07	181	40	5	e47664a264a2c37390d1668ce04eef2e0172f4cb
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgA_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	6.69e-07	186	40	5	e2c050ba02e1f84f0b7258dc92e7ff6ab349ff67
ToppCell	healthy_donor-Lymphocytic-Plasma_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	7.06e-07	188	40	5	bd53b0371154cff680226897b61c9809a239d1b6
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	7.44e-07	190	40	5	79ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	7.44e-07	190	40	5	18762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.03e-07	193	40	5	34f6c13884fdf7f8a87f942fcb36a58cfac3f65d
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.03e-07	193	40	5	282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.24e-07	194	40	5	6ef4aeb8d8e35e4df58ff2a8256caa2113291de9
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.24e-07	194	40	5	f083777353e76a2d9c39f8b6cb1a689b68b81c56
ToppCell	Biopsy_Other_PF-Immune-Plasma_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.45e-07	195	40	5	d0305c6a68c9e361507b04db94f86873085d49b3
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.45e-07	195	40	5	df009b18898c10686f75cf72b4ec0eff18f5bb50
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.67e-07	196	40	5	c38e7f533c619afe008de0e99042f7180c2da918
ToppCell	Biopsy_IPF-Immune-Plasma_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.67e-07	196	40	5	a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.67e-07	196	40	5	fec21383435779bf4c632decd3d29c6ca7baebfb
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.89e-07	197	40	5	2662138671262b30508c5759038bcdcfe6551696
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	8.89e-07	197	40	5	9fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SFTPA1 KLK10 ALDH1A3 SLCO6A1 SUSD2	9.11e-07	198	40	5	5d57acbe0d245f8bd217eeea07af060092898fbd
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgG_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	1.04e-05	152	40	4	a2ba2d95ac9010e1a62db34dcad10d004f8a90cc
ToppCell	368C-Lymphocytic-Plasma_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-7	1.34e-05	162	40	4	f945688815229c8386cbcbf46deee7df316fa8d3
ToppCell	368C-Lymphocytic-Plasma_cell-\|368C / Donor, Lineage, Cell class and subclass (all cells)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-7	1.34e-05	162	40	4	c21a54310b239d999bbc9d8fb5e8fda16e0bc336
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	1.65e-05	171	40	4	c2b7bbabc8f9afa8a1157b567d5f962d4b242919
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-11 HTR3A LCP1 IGKV3-15	1.69e-05	172	40	4	172e3c78f8e97988a4fd8624514e731282ddc16d
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-11 HTR3A LCP1 IGKV3-15	1.69e-05	172	40	4	5fb0ea6145892a258696197b3feed9760187e712
ToppCell	wk_08-11-Hematologic_Lymphocytic-B\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	1.69e-05	172	40	4	d1ab8f493b70ec995281f9fb0991f1d3aa7b928f
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-11 HTR3A LCP1 IGKV3-15	1.69e-05	172	40	4	2214cc37d7c21b868768d3f74ca4631d339d37b3
ToppCell	droplet-Heart-4Chambers-18m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SLAMF9 LCP1 INS	1.69e-05	172	40	4	19ccac3d88382b8b2379d14525b2204c7407cb3b
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-11 HTR3A LCP1 IGKV3-15	1.69e-05	172	40	4	07620728a6cdeea805e1365e588be096c17a370c
ToppCell	Plasma_cells\|World / lung cells shred on cell class, cell subclass, sample id	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	1.73e-05	173	40	4	52a387e2a4694af61a9223a4c2ecf4e6f762c064
ToppCell	IPF-Lymphoid-B_Plasma\|World / Disease state, Lineage and Cell class	IGKV3D-11 IGKV3-15 IGKV3-11 IGKV3-7	1.85e-05	176	40	4	cc0cab6487df6867b529596ec94f55d31aa6ca36
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	1.98e-05	179	40	4	494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCell	cellseq-Immune-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.02e-05	180	40	4	663a800ab70e7ab7d13183417f9c1ed36907aa5e
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.02e-05	180	40	4	cd04d7bf92986a5b8a0193c9b92ec47da3929bac
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFTPA1 C21orf58 PTGIS AGPAT2	2.11e-05	182	40	4	81c394959414173016426961478f670cd822f8b3
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFTPA1 C21orf58 PTGIS AGPAT2	2.11e-05	182	40	4	41a7543c8b703441ff6ac2307faffe5f798b2c41
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.16e-05	183	40	4	5ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.16e-05	183	40	4	cf5c98f451a568308c52da5c926543dd4836c6b2
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.25e-05	185	40	4	08bc817908076734d66f2805cb954141f2cc5a18
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.25e-05	185	40	4	6ec009e48e50471c28e914c402f500e56a88f8f2
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.25e-05	185	40	4	f49ad6401b2abd089e30eba245b11b5031ea2318
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.25e-05	185	40	4	1704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCell	IPF-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.30e-05	186	40	4	f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-B_lymphocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.40e-05	188	40	4	c3cae529fdbeb233d2b32bcc3537a8aba26a7dc2
ToppCell	5'-Adult-LargeIntestine-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.55e-05	191	40	4	d1d30279ed4612b4f62c225d9eabf0b8a7a09d11
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.77e-05	195	40	4	f3f7f1a77a1edd2b50a8211c76fe289738eb04cf
ToppCell	COVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast\|COVID_vent / Disease condition, Lineage, Cell class and subclass	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.82e-05	196	40	4	026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-15 IGKV3D-11 IGKV3-15 IGKV3-11	2.88e-05	197	40	4	88b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCell	COVID_non-vent-Lymphocytic-Plasma_cell-IgG_Plasmablast\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IGKV3D-15 IGKV3D-11 IGKV3-11 IGKV3-7	2.88e-05	197	40	4	b754fad4f3caae6de95df901fd96ea8697fe41b1
ToppCell	LPS_only\|World / Treatment groups by lineage, cell group, cell type	LCP1 SLC22A16 PLK3 SLC2A1	3.00e-05	199	40	4	852cf595c2255983cff9045f2bb746d4391cf5ba
ToppCell	COVID-19-Heart-Fib_+_CM\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ALDH1A3 PTGIS ADCY2	1.39e-04	112	40	3	d00ee6b19e41a35450681fe676885983536d6292
ToppCell	metastatic_Lymph_Node-B_lymphocytes-Plasma_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	IGKV3D-11 IGKV3-15 IGKV3-11	2.79e-04	142	40	3	5ba3a33c2ee20be8baaed97536ca6e9d1de6752f
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RALGAPA1 RNF213 TMEM181	3.09e-04	147	40	3	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	Basal_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	KLK10 ALDH1A3 GAS2	3.82e-04	158	40	3	51e3ed1b91b010404d66e3e7efdbffc0c815e25b
ToppCell	Int-URO-Lymphocyte-B-Plasmablast\|Int-URO / Disease, Lineage and Cell Type	IGKV3D-15 IGKV3D-11 IGKV3-15	3.89e-04	159	40	3	f6ad73b6a3681471efbd4fafd9eb631764c53500
ToppCell	facs-Skin-Anagen-3m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFTPA1 PTGIS INS	4.03e-04	161	40	3	8d2987271da52fd8353557ac6faa4f7a4be0ed2a
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLK10 ALDH1A3 ADCY2	4.11e-04	162	40	3	112fa4de685727f6c8bf6fc4afb82de0524070ad
ToppCell	normal_Lung-Epithelial_cells-Undetermined\|normal_Lung / Location, Cell class and cell subclass	SFTPA1 SUSD2 AGPAT2	4.25e-04	164	40	3	fa2dae15b38cb8f9642dbf00549beec8ee19e9bb
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-Activated_CD8_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF213 LCP1 ATG7	4.25e-04	164	40	3	24fdea5113d92b96f56b06dd2449910a3c785e69
ToppCell	facs-Heart-RA-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLAMF9 LCP1 C21orf58	4.33e-04	165	40	3	995f1524965a4314938f27165166f0aaff9dea02
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-Activated_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF213 LCP1 INS	4.41e-04	166	40	3	fb2cfbf1d0a0f1950dd24c08ba00ebd64b06ceb4
ToppCell	Control-Epithelial-Mesothelial\|Control / Disease state, Lineage and Cell class	KLK10 ALDH1A3 PTGIS	4.41e-04	166	40	3	1ed3788257e14f097862b999f020bfe2a57de52b
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SLAMF9 LCP1	4.49e-04	167	40	3	e85d97f8b0127663a3295db2b22b8488c0148455
ToppCell	367C-Lymphocytic-Plasma_cell-\|367C / Donor, Lineage, Cell class and subclass (all cells)	IGKV3D-11 IGKV3-15 IGKV3-11	4.49e-04	167	40	3	f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SLAMF9 LCP1	4.49e-04	167	40	3	ac21c7112b592e30473e693a2bbee81ff0bb0160
ToppCell	367C-Lymphocytic-Plasma_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	IGKV3D-11 IGKV3-15 IGKV3-11	4.49e-04	167	40	3	5e768cf24699893e05d1bcb1c92dba2336943a64
ToppCell	facs-Tongue-nan-24m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFTPA1 PTGIS INS	4.49e-04	167	40	3	73fdf4b81a45ec686d2929eaf641b434f70b7898
ToppCell	facs-Tongue-nan-24m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFTPA1 PTGIS INS	4.49e-04	167	40	3	c4157fb31b44fe7c44be4215dda8ae2d37cf49a8
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SLAMF9 LCP1	4.49e-04	167	40	3	a54e200789db14f41c9fc8d21cd7fa7cedde77ad
ToppCell	10x5'-GI_large-bowel\|World / Manually curated celltypes from each tissue	IGKV3D-15 IGKV3D-11 IGKV3-11	4.56e-04	168	40	3	1290c909655bc37f6b8bf216d18127a21b99e9c0
ToppCell	tumor_Lung-B_lymphocytes-Plasma_cells\|tumor_Lung / Location, Cell class and cell subclass	IGKV3D-15 IGKV3-15 IGKV3-11	4.64e-04	169	40	3	b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCell	facs-Tongue-nan-24m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFTPA1 PTGIS INS	4.64e-04	169	40	3	0054f9bfd4d377c7fd94873c1308622051c59a8e
ToppCell	droplet-Heart-4Chambers-18m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SLAMF9 LCP1	4.64e-04	169	40	3	ea43002e74076aa03bf688c0a76c07117787d4b5
ToppCell	metastatic_Brain-B_lymphocytes-Plasma_cells\|metastatic_Brain / Location, Cell class and cell subclass	SFTPA1 IGKV3-15 IGKV3-11	4.72e-04	170	40	3	53634da9e9c72f6400639954c286c6e38ea5a188
ToppCell	Control-Lymphoid-B_Plasma\|World / Disease state, Lineage and Cell class	IGKV3D-11 IGKV3-15 IGKV3-11	4.72e-04	170	40	3	fb05f49b7113470995b3c16683c54dc1a660b73a
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	IGKV3D-11 ADCY2 IGKV3-7	4.81e-04	171	40	3	f28684ea0e74a22f4c140658496068e28a6d3605
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV3D-15 IGKV3-15 IGKV3-7	4.81e-04	171	40	3	13126a3fbee181412c13ffb0c347277b9d8f16f7
ToppCell	facs-Marrow-B-cells-24m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLAMF9 INS TMEM181	4.89e-04	172	40	3	65b8935a972bf00b7a10dc2d442128fc0ed78bcb
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3-15 IGKV3-11 IGKV3-7	4.97e-04	173	40	3	0ca2169a275404118038c0489a48062879488765
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	ALDH1A3 SLAMF9 SLC22A16	5.06e-04	174	40	3	1e289b26e2c29dbad15b712a999b96c391a26129
ToppCell	COVID-19-lung-RBC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC22A16 C21orf58 SLC2A1	5.14e-04	175	40	3	4c35292ad2ac712ba7516f27dd6eac6ba8fdd163
ToppCell	metastatic_Brain-B_lymphocytes-MALT_B_cells\|metastatic_Brain / Location, Cell class and cell subclass	IGKV3D-11 IGKV3-15 IGKV3-11	5.23e-04	176	40	3	50e207403d48ce1b55a78897adb5519a2430a626
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC22A16 INS INS-IGF2	5.23e-04	176	40	3	6b04672f295d7680ba00714a72785314a619c893
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TNK1 ALDH1A3 PTGIS	5.31e-04	177	40	3	3d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SFTPA1 C21orf58	5.40e-04	178	40	3	8b7df6ab8709d9ab9dff97677cc4561aec2745bc
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SFTPA1 C21orf58	5.40e-04	178	40	3	58857bb8c13e0e1c6d9f5c1258f00fff62063d68
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV3D-11 IGKV3-15 IGKV3-11	5.40e-04	178	40	3	107dae8b00c4257697a63700e72bb434cdb8406f
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB SFTPA1 C21orf58	5.40e-04	178	40	3	b0baf5667e3301898b3e45e974b8a8530af6a338
Computational	Genes upregulated in subsets of cells of a given type within various tumors	KLK10 ALDH1A3 SLC2A1	1.19e-04	50	21	3	GAVISH_3CA_MALIGNANT_METAPROGRAM_40_PDAC_RELATED
Drug	Laevuflex	SLC2A13 GBA2 ADCY2 INS SLC2A1 AGPAT2	3.97e-06	272	36	6	CID000003426
Disease	Todd Paralysis	TRPM7 INS	5.48e-05	9	37	2	C0234544
Disease	Paralysed	TRPM7 INS	5.48e-05	9	37	2	C0522224
Disease	latent autoimmune diabetes in adults, type 2 diabetes mellitus	INS INS-IGF2	5.48e-05	9	37	2	EFO_0009706, MONDO_0005148
Disease	Weight decreased	ATG7 INS	3.81e-04	23	37	2	C1262477
Disease	Neonatal diabetes mellitus	INS AGPAT2	4.51e-04	25	37	2	C0158981
Disease	ovarian neoplasm	KLK10 ATG7 SLC2A1	6.36e-04	134	37	3	C0919267
Disease	Malignant neoplasm of ovary	KLK10 ATG7 SLC2A1	6.78e-04	137	37	3	C1140680
Disease	lipoprotein-associated phospholipase A(2) measurement	RNF213 LCP1	1.16e-03	40	37	2	EFO_0004746
Disease	Antithrombotic agent use measurement	LCP1 HECTD4	2.18e-03	55	37	2	EFO_0009925
Disease	Alzheimer's disease (biomarker_via_orthology)	INS INS-IGF2	2.42e-03	58	37	2	DOID:10652 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AWKAALPLILVAMGL	BTNL10	251	A8MVZ5
WPMLLSKAIIKLANI	ADGB	236	Q8N7X0
MLLWVQQALLALLLP	HTR3A	1	P46098
NFPLLMLVWKLAPAL	ALDH1A3	181	P47895
LWHLPLLLLLMLTCK	COX10	416	Q12887
MALWMRLLPLLALLA	INS	1	P01308
KQCLLLPLLLLAAWK	PCDHA6	11	Q9UN73
MEAPAQLLFLLLLWL	IGKV3D-11	1	A0A0A0MRZ8
MAWRALHPLLLLLLL	NCR2	1	O95944
LDSIMGNKDLWPLLL	SLC2A1	176	P11166
LMKLSPEELLLRWAN	LCP1	261	P13796
MEAPAQLLFLLLLWL	IGKV3D-15	1	A0A087WSY6
LLLWQLLMAPKDQIC	HECTD4	316	Q9Y4D8
LLQCSKKASPLLMWL	ADCY2	651	Q08462
ANQPNLKLLAMAKLW	CRNKL1	811	Q9BZJ0
NLKLMCWRLVPTLDL	ATG7	336	O95352
ALIMLWPKLELSLQY	GBA2	546	Q9HCG7
LVLQNWMLKALPPAL	C21orf58	256	P58505
AVLMLSWKPLLDLFQ	DPP8	126	Q6V1X1
MEAPAQLLFLLLLWL	IGKV3-11	1	P04433
MEAPAQLLFLLLLWL	IGKV3-15	1	P01624
MEAPAQLLFLLLLWL	IGKV3-7	1	A0A075B6H7
MALWMRLLPLLALLA	INS-IGF2	1	F8WCM5
MELWPCLAAALLLLL	AGPAT2	1	O15120
NLLILLTMWADPKLC	OR10G2	46	Q8NGC3
MLLLKRQLSLDALWQ	SLC2A13	106	Q96QE2
ANLLPMKEDLALWLT	GAS2	31	O43903
MKPALLPWALLLLAT	SUSD2	1	Q9UGT4
MAWAALLGLLAALLL	PTGIS	1	Q16647
LVCDRKWLAMLIQPL	SLC22A16	146	Q86VW1
DLCAALWILMKNPVL	SLCO6A1	371	Q86UG4
LWILMKNPVLICLAL	SLCO6A1	376	Q86UG4
MWLCPLALNLILMAA	SFTPA1	1	Q8IWL2
AWLQLVKNLSMPLEL	RNF213	3881	Q63HN8
PLLLQWVKTDQALLM	PLK3	561	Q9H4B4
LLLCLLDWIMALPLK	RALGAPA1	1391	Q6GYQ0
EQKWMSVLLPLLLLY	TMEM181	346	Q9P2C4
MCAFPWLLLLLLLQE	SLAMF9	1	Q96A28
LHMAALLLLPWLMLL	ZDHHC24	171	Q6UX98
MLPEAGSLWLLKLLR	TNK1	1	Q13470
PLNELLIWACLMKRQ	TRPM7	621	Q96QT4
ALAKLLPLLMAQLWA	KLK10	16	O43240