Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK2 GRK3

3.16e-064152GO:0047696
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK2 GRK3

1.10e-057152GO:0004703
GeneOntologyMolecularFunctionco-SMAD binding

USP9X USP9Y

3.46e-0512152GO:0070410
GeneOntologyMolecularFunctionzinc ion binding

ACE MMP21 RBBP6 SMPD1 APOBEC3D

3.61e-04891155GO:0008270
GeneOntologyMolecularFunctionpeptidase activity

ACE MMP21 USP9X USP9Y

1.17e-03654154GO:0008233
GeneOntologyMolecularFunctiontransition metal ion binding

ACE MMP21 RBBP6 SMPD1 APOBEC3D

1.35e-031189155GO:0046914
GeneOntologyMolecularFunctionSMAD binding

USP9X USP9Y

1.86e-0386152GO:0046332
GeneOntologyMolecularFunctionG protein-coupled receptor binding

ACE GRK2 GRK3

1.86e-03337153GO:0001664
GeneOntologyMolecularFunctionphospholipase activity

SMPD1 ABHD6

3.23e-03114152GO:0004620
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP9X USP9Y

3.23e-03114152GO:0004843
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ACE MMP21

3.57e-03120152GO:0004222
GeneOntologyMolecularFunctionendopeptidase activity

ACE MMP21 USP9X

3.72e-03430153GO:0004175
GeneOntologyMolecularFunctiondeubiquitinase activity

USP9X USP9Y

3.81e-03124152GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP9X USP9Y

4.63e-03137152GO:0019783
GeneOntologyMolecularFunctionlipase activity

SMPD1 ABHD6

4.69e-03138152GO:0016298
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP9X USP9Y

8.89e-03192152GO:0008234
GeneOntologyMolecularFunctionmetallopeptidase activity

ACE MMP21

9.62e-03200152GO:0008237
GeneOntologyBiologicalProcessnegative regulation of D-glucose import

ACE GRK2

1.27e-0425142GO:0046325
GeneOntologyBiologicalProcessnegative regulation of D-glucose transmembrane transport

ACE GRK2

1.84e-0430142GO:0010829
GeneOntologyBiologicalProcessdesensitization of G protein-coupled receptor signaling pathway

GRK2 GRK3

1.97e-0431142GO:0002029
GeneOntologyBiologicalProcessnegative adaptation of signaling pathway

GRK2 GRK3

2.10e-0432142GO:0022401
GeneOntologyBiologicalProcessadaptation of signaling pathway

GRK2 GRK3

2.10e-0432142GO:0023058
GeneOntologyBiologicalProcessregulation of G protein-coupled receptor signaling pathway

GRK2 GRK3 ABHD6

2.25e-04181143GO:0008277
GeneOntologyBiologicalProcesshematopoietic progenitor cell differentiation

ACE MMP21 APOBEC3D

2.89e-04197143GO:0002244
GeneOntologyBiologicalProcessmaintenance of protein localization in organelle

KDELR1 GRK2

4.54e-0447142GO:0072595
GeneOntologyBiologicalProcesspositive regulation of vasoconstriction

ACE GRK2

6.00e-0454142GO:0045907
GeneOntologyBiologicalProcessphospholipid catabolic process

SMPD1 ABHD6

7.40e-0460142GO:0009395
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

ACE USP9X DDX20 GRK2 USP9Y

8.31e-041194145GO:0048609
GeneOntologyBiologicalProcesspositive regulation of apoptotic process

ACE SMPD1 DDX20 GRK2

1.10e-03718144GO:0043065
GeneOntologyBiologicalProcessmaintenance of protein location in cell

KDELR1 GRK2

1.18e-0376142GO:0032507
GeneOntologyBiologicalProcesspositive regulation of programmed cell death

ACE SMPD1 DDX20 GRK2

1.23e-03739144GO:0043068
GeneOntologyBiologicalProcessnegative regulation of G protein-coupled receptor signaling pathway

GRK2 GRK3

1.34e-0381142GO:0045744
GeneOntologyBiologicalProcessregulation of D-glucose import

ACE GRK2

1.34e-0381142GO:0046324
GeneOntologyBiologicalProcesscoronary vasculature development

ACE MMP21

1.41e-0383142GO:0060976
GeneOntologyBiologicalProcessviral life cycle

SMPD1 APOBEC3D GRK2

1.41e-03340143GO:0019058
DomainGPCR_kinase

GRK2 GRK3

1.26e-057152IPR000239
DomainEpox_hydrolase-like

EPHX4 ABHD6

1.68e-058152IPR000639
DomainAbhydrolase_1

EPHX4 ABHD6

2.76e-0431152PF00561
DomainAB_hydrolase_1

EPHX4 ABHD6

3.13e-0433152IPR000073
DomainRGS

GRK2 GRK3

3.53e-0435152PF00615
DomainRGS

GRK2 GRK3

3.53e-0435152SM00315
DomainRGS

GRK2 GRK3

3.73e-0436152PS50132
DomainRGS

GRK2 GRK3

4.39e-0439152IPR016137
DomainAGC-kinase_C

GRK2 GRK3

9.04e-0456152IPR000961
DomainAGC_KINASE_CTER

GRK2 GRK3

9.04e-0456152PS51285
DomainS_TK_X

GRK2 GRK3

9.04e-0456152SM00133
DomainUSP_CS

USP9X USP9Y

1.25e-0366152IPR018200
DomainUSP_1

USP9X USP9Y

1.41e-0370152PS00972
DomainUCH

USP9X USP9Y

1.45e-0371152PF00443
DomainUSP_2

USP9X USP9Y

1.45e-0371152PS00973
DomainUSP_dom

USP9X USP9Y

1.49e-0372152IPR028889
DomainPeptidase_C19_UCH

USP9X USP9Y

1.49e-0372152IPR001394
DomainUSP_3

USP9X USP9Y

1.49e-0372152PS50235
DomainZINC_PROTEASE

ACE MMP21

2.74e-0398152PS00142
Domain-

EPHX4 ABHD6

4.00e-031191523.40.50.1820
DomainAB_hydrolase

EPHX4 ABHD6

4.00e-03119152IPR029058
DomainPH

GRK2 GRK3

1.41e-02229152PF00169
DomainARM-like

USP9X USP9Y

1.93e-02270152IPR011989
DomainPH

GRK2 GRK3

2.04e-02278152SM00233
DomainPH_DOMAIN

GRK2 GRK3

2.05e-02279152PS50003
DomainPH_domain

GRK2 GRK3

2.07e-02280152IPR001849
DomainARM-type_fold

USP9X USP9Y

2.95e-02339152IPR016024
DomainSer/Thr_kinase_AS

GRK2 GRK3

3.25e-02357152IPR008271
DomainS_TKc

GRK2 GRK3

3.28e-02359152SM00220
DomainPROTEIN_KINASE_ST

GRK2 GRK3

3.33e-02362152PS00108
DomainProtein_kinase_ATP_BS

GRK2 GRK3

3.62e-02379152IPR017441
DomainPkinase

GRK2 GRK3

3.66e-02381152PF00069
Domain-

GRK2 GRK3

3.83e-023911522.30.29.30
Pubmed

Cloning of GRK2 cDNA from S49 murine lymphoma cells.

GRK2 GRK3

1.74e-0721528638670
Pubmed

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

GRK2 GRK3

1.74e-07215210198406
Pubmed

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

GRK2 GRK3

1.74e-07215233060647
Pubmed

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.

GRK2 GRK3

1.74e-07215211762794
Pubmed

G protein--coupled receptor kinases.

GRK2 GRK3

1.74e-0721528035170
Pubmed

The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.

USP9X USP9Y

1.74e-0721528922996
Pubmed

Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.

USP9X USP9Y

1.74e-07215212925892
Pubmed

Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.

USP9X USP9Y

1.74e-07215212895410
Pubmed

Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.

GRK2 GRK3

5.21e-07315210754297
Pubmed

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

GRK2 GRK3

5.21e-07315210085131
Pubmed

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

GRK2 GRK3

5.21e-0731527761854
Pubmed

The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.

GRK2 GRK3

5.21e-07315231604529
Pubmed

Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.

GRK2 GRK3

5.21e-07315212130708
Pubmed

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.

GRK2 GRK3

1.04e-0641528917529
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK2 GRK3

1.04e-06415221784156
Pubmed

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.

GRK2 GRK3

1.04e-0641528662816
Pubmed

Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.

GRK2 GRK3

1.04e-06415223734232
Pubmed

Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.

GRK2 GRK3

1.73e-06515210338466
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK2 GRK3

2.60e-0661529826657
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK2 GRK3

2.60e-06615236451830
Pubmed

Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.

GRK2 GRK3

2.60e-06615220074556
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK2 GRK3

3.64e-0671528672451
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK2 GRK3

3.64e-06715211517230
Pubmed

Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.

GRK2 GRK3

6.24e-06915234873237
Pubmed

Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron.

USP9X DDX20

6.24e-06915223112048
Pubmed

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.

GRK2 GRK3

7.80e-06101521869533
Pubmed

Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.

USP9X USP9Y

7.80e-06101529384609
Pubmed

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.

USP9X USP9Y

1.14e-051215223861879
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP9X USP9Y

1.82e-05151529827704
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

USP9X USP9Y

1.82e-051515214762062
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP9X USP9Y

2.35e-051715223287719
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

USP9X USP9Y

2.65e-051815212023983
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

USP9X GRK2 GRK3 USP9Y

2.88e-0543215423455922
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

USP9X DDX20 USP9Y

1.46e-0424415329884807
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

RBBP6 USP9X DDX20

3.03e-0431315338270169
InteractionBDKRB2 interactions

ACE GRK2 GRK3

2.55e-0637153int:BDKRB2
InteractionCLK3 interactions

RBBP6 USP9X APOBEC3D USP9Y

1.72e-05220154int:CLK3
InteractionGRK3 interactions

GRK2 GRK3

1.08e-0421152int:GRK3
GeneFamilyAbhydrolase domain containing

EPHX4 ABHD6

7.72e-05221124
GeneFamilyUbiquitin specific peptidases

USP9X USP9Y

5.09e-0456112366
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

GRK2 GRK3

6.64e-03206112682
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK2 GRK3

2.25e-05168153f45dbcd7753117a3e41e1412bce2100d52fa7fd0
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK2 GRK3

2.29e-051691532d3618f78484bd3508b7bdae3a0d0183cdae5057
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK2 GRK3

2.33e-05170153f08aa6168ff0c20b2083dbf588dd3294e3d9580e
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX4 ACE GRK3

2.33e-05170153f5140eb9313c0d1bb31f8a761d9c062c56733a61
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX4 ACE GRK3

2.33e-051701538e774af244cfe787fa0ea2b6be0c3c2d00bfe4fc
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature2_(1)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

EPHX4 ACE ABHD6

3.56e-051961530e8d649b50be2d707510b897bb97767b5847dff9
ToppCellCOVID-19_Mild-dn_T|COVID-19_Mild / Disease condition and Cell class

GRK2 GRK3

6.77e-0411615279c918f3bebfd5e0b865d2c7673af9ee3bc48779
ToppCellMyeloid-Myeloid-C_(Cd16+_Monocyte)|Myeloid / shred on cell class and cell subclass (v4)

ACE GRK3

6.89e-04117152d1936e76a935216783a73ab414e4147fa48e68eb
ToppCellMild/Remission-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3

7.36e-0412115268940a552233d255b90ce5a081339c0d9d46ab02
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_B|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ACE ABHD6

7.60e-04123152e0130010aa406d4e9d8f16ad32858c382277eeb2
ToppCellMyeloid-C_(Cd16+_Monocyte)|World / shred on cell class and cell subclass (v4)

GRK2 GRK3

7.85e-04125152c73a77340e79f73fd1f900724e82a94d82e6b1bf
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

EPHX4 MMP21

7.98e-04126152feedea978d76de326c14da5149e57d0d767271b9
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EPHX4 MMP21

7.98e-041261526311cc64320db7e24a09065ebdf054f5f551b182
ToppCelldroplet-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.03e-031431524d11d53330a9197275a8851e1bbf55a113715a09
ToppCellMild/Remission-B_naive-1|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3

1.03e-03143152bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCelldroplet-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.03e-031431528b9f4d87d5faac7752c83e1992491fc5550600f8
ToppCellControl-B_intermediate-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3

1.04e-03144152984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCellControl-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

MMP21 GRK2

1.07e-03146152fcd8548b42275758d7d77ad2651afe7ad0e5ea2a
ToppCelldroplet-Lung-3m-Hematologic-myeloid-intermediate_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.13e-03150152b37f538ca5f976b509efe35dc81115b72b227084
ToppCelldroplet-Lung-3m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.13e-031501522c7518918c40e1bf679a2d4e83b472ee6f2f9df8
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.16e-0315215282a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCelldroplet-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.17e-03153152f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCelldroplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.17e-031531526dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3

1.20e-031551520a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.23e-03157152d8e283414a770f05d71f0455d0822e9a9660b115
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.23e-03157152165e98bf944572cafbc06ef43c9eab7bd6bea1c2
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3

1.25e-03158152b0508a600994090c6aafd8d779437190a33ad821
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.25e-0315815290ca742739a208d457db087655ba3d1c18a9da57
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.25e-0315815291d265e95156f16459924d3e4dd11c180e164eee
ToppCellfacs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3

1.25e-03158152a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.26e-03159152cdbccb83af6220bab300dfe56443ff69f6e2043a
ToppCellSevere-B_naive-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3

1.26e-031591522881b054bbeb479221ee3c38bbd9b0815b123579
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.28e-031601528dae9b0cf90a09acb196223f45a14680102630b2
ToppCelldroplet-Lung-nan-21m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.28e-031601524738d0c73d8c3508e5b5beb6c61e0ad551d9b949
ToppCelldroplet-Lung-nan-21m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.28e-031601520b8151037b28f52a21918856a1e9336e8d5edb90
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EPHX4 ACE

1.28e-031601528bb873704895c3b35bba8af78fedbabf7df42e71
ToppCellfacs-Spleen-nan-3m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.30e-031611529cf1dcf0e7ca9e35c46c094a6b78f98d1f6b9276
ToppCellfacs-Spleen-nan-3m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.30e-0316115245591addc765760db6029ac19e80573373d1d917
ToppCellfacs-Spleen-nan-3m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.30e-031611528741b91a62c9a8ce377ef6533d323b65beb93c63
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.31e-0316215293bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.33e-03163152f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCellControl-APC-like-Monocytes|Control / group, cell type (main and fine annotations)

STEAP1B APOBEC3D

1.33e-031631524bc80a2c741d462724b6f3902377d48c57478932
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.34e-03164152ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3

1.34e-0316415215d52666e5150e7c34b1f641a937fb2d5e8aaf8a
ToppCellfacs-Lung-EPCAM-24m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3

1.34e-03164152d622f0d8d8bad48dfdf160ec63c545df192637a9
ToppCelldroplet-Lung-nan-18m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.36e-03165152e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.36e-0316515211227bff52eed30b80937fdb1968d0b8e6d30365
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.36e-03165152036f9749048e5e50769cc3210339bf4da469215d
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_1|COVID-19_Mild / Disease condition and Cell class

GRK2 GRK3

1.36e-03165152ef709c5d3231c65d351316e1e31b9c9eba721628
ToppCelldroplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.36e-031651520fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCelldroplet-Spleen-nan-18m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.38e-031661523ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCelldroplet-Lung-LUNG-1m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.38e-03166152dd5944101ef58a9a29aa3eb5c17690119572b8f1
ToppCelldroplet-Spleen-nan-18m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.38e-03166152e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCelldroplet-Spleen-nan-18m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.38e-03166152f751cbd01d4978ded7755874ab60504f6291afd7
ToppCellCOVID-CD8-exh_CD4|COVID / Condition, Cell_class and T cell subcluster

ACE SMPD1

1.38e-031661524ca8c91b03d08489f244898cf9423b9d10348bc8
ToppCellCOVID-19_Severe-PLT_1|World / Disease Group and Platelet Clusters

RBBP6 SMPD1

1.38e-031661522c89b45eb20e24aae165f1a8e61680d3b63210ac
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.38e-031661528e5e8de51b4dacdadaa5a08279df30b5c7ed3628
ToppCelldroplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.38e-031661521a3a15d1fc76bb91d832cdc6e3da0a6140b94b75
ToppCelldroplet-Kidney-nan-24m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.39e-031671522ee1660be117e20f24557522345572d11cbee813
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3

1.39e-03167152948504367ecf58144d9dd74d2ec531358fc4b309
ToppCelldroplet-Lung-30m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.41e-03168152d823979335ac6b5d1f062ebb741c759d2f919dbf
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_1|Classical_Monocyte / Disease condition and Cell class

GRK2 GRK3

1.41e-03168152d50078614f7af74dc2aa4081c1708a5156ac51cf
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.41e-03168152f3b7a7df54988de77dcc7066e2fc1feb9c280b13
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.41e-03168152e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCelldroplet-Lung-18m-Hematologic-myeloid-intermediate_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.41e-0316815200cff4698db14e03ca1d1b409e5ed1ad23b12615
ToppCelldroplet-Lung-30m-Hematologic-myeloid-non-classical_monocyte|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.41e-03168152f377ff4c066a9857ad14d245e56325ad220e22e1
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.41e-03168152689c41f6e9f65381570991cc311cba49a57ec955
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRK2 GRK3

1.41e-03168152c0aef5947b1d7e2c81a7481c509feda1687fcd7f
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRK2 GRK3

1.41e-03168152c861f80aa12caf54a94d93e38539ff41dc5227a6
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.41e-031681524b5be7c6662eceddf90a65015f12908278d1664e
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.43e-03169152b059304543876f514d5c7214f1f0a2da00f10a67
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.43e-03169152945f737984c4de70a4e9c214053b005358053dd5
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.43e-03169152411556e93adcbb7e4d79b02f3dc72963ec8a0759
ToppCelldroplet-Lung-18m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.43e-0316915290c00ab30e582b0e2a2be751e1fae9024cfb9ea6
ToppCelldroplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.43e-03169152c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACE ACBD5

1.43e-0316915241ad349806b279fbe1374b7e3cc7f146a11adb44
ToppCelldroplet-Spleen-nan-3m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.43e-0316915291cfff1ad559cc327c6bb71c98aa29f0b3642568
ToppCelldroplet-Spleen-nan-3m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.43e-03169152972618e684321060c7af2429f853a6d639e8aae8
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

EPHX4 ACE

1.43e-03169152b66ffc2b2b6bfcc3a6e639d9d31d3de95f4a94e1
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACE ACBD5

1.43e-0316915242782c61592742190ab0cba8a94f8bdf9c278f90
ToppCelldroplet-Lung-LUNG-30m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.43e-0316915239b1acfd099abb9de18c29c05c7a67709ea76775
ToppCelldroplet-Lung-nan-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.43e-03169152ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCelldroplet-Spleen-nan-3m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.43e-031691528e5e513090e86ca29fb61dfd388014774c506914
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.44e-031701527cb7ad9ab064b6ea452545d145e5b1d4090cd4c1
ToppCellfacs-SCAT-Fat-24m-Myeloid-myeloid_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3

1.44e-0317015213480e5f2de50425e42be0144b876e9aa4006a68
ToppCelldroplet-Lung-1m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.44e-031701524d28dc9eb572f43809619f923978cd7494853d43
ToppCellfacs-SCAT-Fat-24m-Myeloid-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3

1.44e-03170152d22cd09a43a14045bb1181189fe8accf78fdde3b
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.44e-03170152db7cee7e518debb2cbe9eeae05d47e14b69cb8e3
ToppCelldroplet-Spleen-nan-21m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.44e-0317015203cb4e508356f85372a588c8d1c6babf2a012683
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK3 USP9Y

1.44e-03170152ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCellfacs-SCAT-Fat-24m-Myeloid|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3

1.44e-03170152f9968d3735328a39157764343dd40f1ad8bf710d
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK3 USP9Y

1.44e-03170152a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCelldroplet-Spleen-nan-21m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.46e-031711529498c35b2a2c3a339dc8c5d49c8ec20d8ad52753
ToppCelldroplet-Spleen-nan-21m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.46e-03171152db544252f98e073e5bb4bec4a110cd58e6434435
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK2

1.46e-03171152355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCelldroplet-Lung-1m-Hematologic-myeloid-intermediate_monocyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.46e-03171152ed5886d6aa87b2d73469d39dc217227bd4d4c918
ToppCellControl-B_naive-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3

1.46e-03171152d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCelldroplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE GRK3

1.46e-0317115200739085fdbc4d64c9faacba2c2adeab580dd2b1
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.48e-031721526aab59add5b180cee0ca31179c620e89d352d5c1
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE GRK3

1.48e-0317215266823536288c7009ce01b5177794a3e874e94570
Drugmilrinone

ACE SMPD1 GRK2 GRK3

2.33e-06150154CID000004197
DrugT-kinin

ACE GRK2 GRK3

2.43e-0641153CID000123643
DrugDesipramine

SMPD1 GRK2 GRK3

3.69e-0647153ctd:D003891
Drugtriethylamine

GRK2 GRK3 ABHD6

4.45e-0650153CID000008471
DrugbetaARKct

GRK2 GRK3

6.07e-066152CID000002295
DrugLoracarbef [121961-22-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A

SMPD1 GRK2 GRK3 ABHD6

6.89e-061971543532_DN
Drugv 18

SMPD1 ABHD6

8.49e-067152CID000008305
Drugcholesteryl octanoate

SMPD1 ABHD6

1.13e-058152CID000102015
DrugSCT-1

GRK2 GRK3

1.45e-059152CID000211458
Drugsodium nitroprusside

ACE SMPD1 GRK2 GRK3

2.09e-05261154CID000045469
Drug1,3-diolein

GRK2 GRK3 ABHD6

2.63e-0590153CID000033120
Druggeranyl nitrile

GRK2 GRK3

3.15e-0513152CID000021768
Drugfluorescein dilaurate

SMPD1 ABHD6

3.67e-0514152CID000081743
Drug8-N3cAMP

GRK2 GRK3

3.67e-0514152CID006426627
Drug8-(6-aminohexyl)amino cyclic AMP

GRK2 GRK3

3.67e-0514152CID000161999
Drugmetoprolol

ACE GRK2 GRK3

4.17e-05105153CID000004171
DrugNA-382

GRK2 GRK3

4.23e-0515152CID000132534
DrugRo-1724

SMPD1 GRK2 GRK3

4.79e-05110153CID000005087
Drugmonodansylcadaverine

SMPD1 GRK2 GRK3

4.92e-05111153CID000004247
Drugphorbol-13-acetate

RBBP6 DDX20 GRK2 GRK3

4.97e-05326154CID000499953
Drug8-azido cyclic AMP

GRK2 GRK3

6.16e-0518152CID000115296
Drug8-thiomethyl-cAMP

GRK2 GRK3

6.88e-0519152CID000093140
Drug8-azidoadenosine

GRK2 GRK3

6.88e-0519152CID000160751
DrugFlorisil

SMPD1 GRK2 GRK3

8.61e-05134153CID000026924
DrugSp-8-Cl-cAMPS

GRK2 GRK3

9.29e-0522152CID000133987
DrugDiC8

GRK2 GRK3 ABHD6

1.11e-04146153CID000001323
Drugtripalmitin

SMPD1 ABHD6

1.20e-0425152CID000011147
Drugcarbodiimide

GRK2 GRK3 ABHD6

1.23e-04151153CID000009864
Drugnifedipine

ACE SMPD1 GRK2 GRK3

1.27e-04415154CID000004485
Drugamthamine

GRK2 GRK3

1.30e-0426152CID000126688
Drug7B-forskolin

GRK2 GRK3

1.30e-0426152CID000130638
DrugH 85

GRK2 GRK3

1.30e-0426152CID006439306
DrugAC1L1FDT

ACE ABHD6

1.30e-0426152CID000003193
Drugdihydrochloride

SMPD1 GRK2 GRK3

1.43e-04159153CID000070978
Drugcalmidazolium chloride

ACE GRK2 GRK3

1.46e-04160153CID000002531
Drugcalphostin C

ACE SMPD1 GRK2 GRK3

1.46e-04431154CID000002533
Drugphosphatidate

SMPD1 GRK2 GRK3 ABHD6

1.48e-04432154CID005460104
Drugdipyridamole

ACE GRK2 GRK3

1.51e-04162153CID000003108
Drug1 PM

ACE SMPD1

1.52e-0428152CID000004315
DrugAC1O5WLA

GRK2 GRK3

1.74e-0430152CID006442113
DrugAC1L1BDQ

GRK2 GRK3 ABHD6

1.83e-04173153CID000001394
Drugacephate

ACE SMPD1

2.11e-0433152CID000001982
DrugN6-monobutyryl-cAMP

GRK2 GRK3

2.11e-0433152CID000115029
DrugAdenosine triphosphate

GRK2 GRK3

2.11e-0433152DB00171
DrugPyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; MCF7; HT_HG-U133A

GRK2 GRK3 ABHD6

2.27e-041861533518_DN
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA

RBBP6 GRK3 ABHD6

2.27e-04186153831_DN
DrugNPLA

GRK2 GRK3

2.38e-0435152CID000004387
Druggeldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A_EA

RBBP6 GRK2 ABHD6

2.45e-041911531008_DN
DrugDiphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT_HG-U133A

KDELR1 GRK2 ABHD6

2.45e-041911534299_DN
DrugTannins

GRK2 GRK3

2.52e-0436152CID000250395
Drugdihydropyridine

ACE GRK2 GRK3

2.53e-04193153CID000104822
Drug(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; MCF7; HT_HG-U133A

SMPD1 GRK2 ABHD6

2.57e-041941533384_DN
DrugAC1Q5THZ

KDELR1 ACE GRK2 GRK3

2.63e-04502154CID000001959
DrugHippeastrine hydrobromide [22352-41-6]; Up 200; 10uM; PC3; HT_HG-U133A

ACE SMPD1 GRK2

2.65e-041961533682_UP
Drugradicicol; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMPD1 GRK2 GRK3

2.65e-041961535947_DN
DrugNSC311040

USP9X USP9Y

2.66e-0437152CID000329293
DrugAmodiaquin dihydrochloride dihydrate [6398-98-7]; Down 200; 8.6uM; MCF7; HT_HG-U133A

GRK2 GRK3 ABHD6

2.69e-041971533186_DN
DrugSB 203580; Up 200; 1uM; MCF7; HT_HG-U133A

SMPD1 GRK2 GRK3

2.69e-041971537061_UP
DrugLymecycline [992-21-2]; Down 200; 6.6uM; MCF7; HT_HG-U133A

GRK2 GRK3 ABHD6

2.69e-041971533514_DN
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

SMPD1 GRK2 ABHD6

2.73e-041981534367_DN
Drug15(S)-15-methyl Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A

SMPD1 GRK3 ABHD6

2.73e-041981537521_DN
DrugTiclopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; MCF7; HT_HG-U133A

SMPD1 GRK2 GRK3

2.77e-041991531475_DN
DrugAC1NR9P8

GRK2 GRK3

2.81e-0438152CID005287445
DrugBolton-Hunter reagent

GRK2 GRK3

2.81e-0438152CID000123813
DrugCyclopenthiazide [742-20-1]; Down 200; 10.6uM; HL60; HT_HG-U133A

SMPD1 GRK2 ABHD6

2.81e-042001532905_DN
DrugCGS 15943

GRK2 GRK3

2.96e-0439152CID000002690
Drug8-chloroadenosine

GRK2 GRK3

3.11e-0440152CID000147569
Drug1d3q

GRK2 GRK3

3.11e-0440152CID000001635
Drug3 SA

GRK2 GRK3

3.27e-0441152CID000449164
Drugamrinone

GRK2 GRK3

3.60e-0443152CID000003698
DrugAminosweet

ACE SMPD1

3.60e-0443152CID000002242
DrugAC1L2WD4

SMPD1 ABHD6

3.77e-0444152CID000078971
Drugtyrphostin AG1296

GRK2 GRK3

3.77e-0444152CID000002049
DrugAH6809

GRK2 GRK3

3.95e-0445152CID000119461
Drughistamine

ACE SMPD1 GRK2 GRK3

3.98e-04560154CID000000774
Drugdibutyryl cyclic 3',5'-AMP

ACE MMP21 GRK2 GRK3

4.01e-04561154CID000002460
DrugNPC 15437

GRK2 GRK3

4.12e-0446152CID000004548
DrugRp-8-Br-cGMPS

GRK2 GRK3

4.12e-0446152CID003035839
DrugD-myo-inositol-1,4,5-triphosphate

ACE SMPD1 GRK2 GRK3

4.20e-04568154CID000000806
DrugAC1L1GI5

ACE GRK2

4.31e-0447152CID000003693
Drugnoradrealine

ACE MMP21 GRK2 GRK3

4.40e-04575154CID000000951
DrugAC1Q6XL6

SMPD1 ABHD6

4.68e-0449152CID000014445
DrugStarlicide

GRK2 GRK3

4.68e-0449152CID000007255
DrugZm 241385

GRK2 GRK3

4.68e-0449152CID000176407
Drugalpha-naphthyl acetate

KDELR1 ABHD6

4.87e-0450152CID000013247
Drugaliskiren

ACE SMPD1

4.87e-0450152CID005493444
DrugAC1NST48

KDELR1 SMPD1 GRK2 GRK3

4.98e-04594154CID005315496
DrugCGP 20712A

GRK2 GRK3

5.07e-0451152CID000002685
Druggenistein

KDELR1 ACE MMP21 GRK2 GRK3

5.60e-041117155CID005280961
DrugHCCA

GRK2 GRK3

6.11e-0456152CID000000584
Drugtrapidil

GRK2 GRK3

6.33e-0457152CID000005531
Drugazafagomine

USP9X USP9Y

6.33e-0457152CID011957435
Drug7-methoxycoumarin

SMPD1 ABHD6

6.33e-0457152CID000010748
Drugnilotinib

SMPD1 ABHD6

6.56e-0458152CID000644241
Drugdihydrocytochalasin B

GRK2 GRK3

6.56e-0458152CID000003064
DiseaseParkinson's disease (biomarker_via_orthology)

GRK2 GRK3

9.02e-0530142DOID:14330 (biomarker_via_orthology)
DiseaseCardiovascular Diseases

ACE GRK2

1.30e-0436142C0007222
Diseasehypertension (biomarker_via_orthology)

ACE GRK2 GRK3

1.54e-04227143DOID:10763 (biomarker_via_orthology)
Diseasecongestive heart failure (is_marker_for)

GRK2 GRK3

6.79e-0482142DOID:6000 (is_marker_for)
Diseaseliver cirrhosis (is_marker_for)

ACE GRK2

6.79e-0482142DOID:5082 (is_marker_for)
DiseaseKidney Diseases

ACE SMPD1

7.82e-0488142C0022658
Diseasecongestive heart failure (biomarker_via_orthology)

ACE GRK2

1.15e-03107142DOID:6000 (biomarker_via_orthology)
DiseaseLeft-Sided Heart Failure

ACE GRK2

1.22e-03110142C0023212
DiseaseMyocardial Failure

ACE GRK2

1.22e-03110142C1959583
DiseaseHeart Failure, Right-Sided

ACE GRK2

1.22e-03110142C0235527
DiseaseCongestive heart failure

ACE GRK2

1.22e-03110142C0018802
DiseaseHeart failure

ACE GRK2

1.22e-03110142C0018801
DiseaseHeart Decompensation

ACE GRK2

1.22e-03110142C1961112

Protein segments in the cluster

PeptideGeneStartEntry
RIYYWYWRRTLGMQV

ABHD6

36

Q9BV23
WQRRYFYLFPNRLEW

GRK3

576

P35626
SAARLYYYRDRDWRW

APOBEC3D

131

Q96AK3
YYYRDRDWRWVLLRL

APOBEC3D

136

Q96AK3
SRYNFDWWYLRTKYQ

ACE

486

P12821
SWSWNYYRIVARYEN

SMPD1

436

P17405
FIAQWLVYLYYQRRR

ACBD5

516

Q5T8D3
QDYEEYWRAYYRAWQ

DDX20

771

Q9UHI6
WQRRYFYLFPNRLEW

GRK2

576

P25098
WYSWRYQLREFKSEY

EPHX4

106

Q8IUS5
TYFFRNSWYWLYENR

MMP21

356

Q8N119
RYREWERKYREWYEK

RBBP6

826

Q7Z6E9
GVYRTLYLFNWIWRY

KDELR1

156

P24390
RQKRWWNAYILFYER

USP9X

1941

Q93008
RRSYRYKLLNWAYQQ

STEAP1B

166

Q6NZ63
YRRQKRWWNAYILFY

USP9Y

1941

O00507