Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3-phosphoinositide-dependent protein kinase activity	PDPK1 PDPK2P	7.45e-06	2	55	2	GO:0004676
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	PIM3 BMPR1B PDPK1 MAP3K13 PDPK2P STKLD1 MAP4K2	2.13e-04	446	55	7	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 PDPK2P STKLD1 MAP4K2	2.22e-04	600	55	8	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 PDPK2P STKLD1 MAP4K2	6.76e-04	709	55	8	GO:0016773
GeneOntologyMolecularFunction	histone binding	BPTF ZZZ3 BRD3 CHD7 CTSL	8.02e-04	265	55	5	GO:0042393
GeneOntologyMolecularFunction	kinase activity	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 PDPK2P STKLD1 MAP4K2	1.10e-03	764	55	8	GO:0016301
GeneOntologyCellularComponent	mitotic cohesin complex	STAG1 STAG2	1.42e-04	7	55	2	GO:0030892
GeneOntologyCellularComponent	cohesin complex	STAG1 STAG2	3.68e-04	11	55	2	GO:0008278
GeneOntologyCellularComponent	GATOR2 complex	CASTOR1 SESN2	4.41e-04	12	55	2	GO:0061700
GeneOntologyCellularComponent	Seh1-associated complex	CASTOR1 SESN2	7.97e-04	16	55	2	GO:0035859
MousePheno	abnormal adrenal cortex morphology	GRAMD1B PDPK1 NR5A1 PDPK2P	1.14e-05	42	47	4	MP:0008288
MousePheno	abnormal adrenal gland zona fasciculata morphology	GRAMD1B PDPK1 PDPK2P	3.32e-05	19	47	3	MP:0008294
MousePheno	pancreatic islet hypoplasia	PDPK1 PDPK2P	6.61e-05	4	47	2	MP:0009169
MousePheno	absent dorsal root ganglion	PDPK1 PDPK2P	1.10e-04	5	47	2	MP:0008460
Domain	STAG	STAG1 STAG2	4.90e-05	4	54	2	IPR013721
Domain	SCD	STAG1 STAG2	4.90e-05	4	54	2	PS51425
Domain	SCD	STAG1 STAG2	4.90e-05	4	54	2	IPR020839
Domain	STAG	STAG1 STAG2	4.90e-05	4	54	2	PF08514
Domain	Pkinase	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 STKLD1 MAP4K2	1.08e-04	381	54	7	PF00069
Domain	BROMODOMAIN_1	BPTF BRD8 BRD3	1.66e-04	37	54	3	PS00633
Domain	Bromodomain	BPTF BRD8 BRD3	1.79e-04	38	54	3	PF00439
Domain	BROMODOMAIN_2	BPTF BRD8 BRD3	2.25e-04	41	54	3	PS50014
Domain	BROMO	BPTF BRD8 BRD3	2.42e-04	42	54	3	SM00297
Domain	Bromodomain	BPTF BRD8 BRD3	2.42e-04	42	54	3	IPR001487
Domain	-	BPTF BRD8 BRD3	2.42e-04	42	54	3	1.20.920.10
Domain	PROTEIN_KINASE_ATP	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 STKLD1 MAP4K2	3.38e-04	459	54	7	PS00107
Domain	Prot_kinase_dom	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 STKLD1 MAP4K2	4.94e-04	489	54	7	IPR000719
Domain	PROTEIN_KINASE_DOM	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 STKLD1 MAP4K2	5.18e-04	493	54	7	PS50011
Domain	Ser/Thr_kinase_AS	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 MAP4K2	5.57e-04	357	54	6	IPR008271
Domain	S_TKc	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 MAP4K2	5.74e-04	359	54	6	SM00220
Domain	Channel_four-helix_dom	CACNA1F KCND1 SCN4A	5.99e-04	57	54	3	IPR027359
Domain	-	CACNA1F KCND1 SCN4A	5.99e-04	57	54	3	1.20.120.350
Domain	PROTEIN_KINASE_ST	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 MAP4K2	6.00e-04	362	54	6	PS00108
Domain	Kinase-like_dom	PIM3 BMPR1B WEE1 PDPK1 MAP3K13 STKLD1 MAP4K2	9.06e-04	542	54	7	IPR011009
Domain	Bromodomain_CS	BPTF BRD3	2.55e-03	26	54	2	IPR018359
Domain	Ion_trans_dom	CACNA1F KCND1 SCN4A	4.38e-03	114	54	3	IPR005821
Domain	Ion_trans	CACNA1F KCND1 SCN4A	4.38e-03	114	54	3	PF00520
Domain	Protein_kinase_ATP_BS	PIM3 BMPR1B WEE1 PDPK1 MAP4K2	4.69e-03	379	54	5	IPR017441
Domain	ARM-like	STAG1 TELO2 STKLD1 STAG2	7.67e-03	270	54	4	IPR011989
Pathway	REACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ	PDPK1 PDPK2P	1.23e-04	6	41	2	MM15665
Pathway	KEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION	STAG1 STAG2	1.72e-04	7	41	2	M47869
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_LOADING	STAG1 STAG2	2.93e-04	9	41	2	M47868
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	STAG1 STAG2	3.66e-04	10	41	2	M27178
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	STAG1 STAG2	3.66e-04	10	41	2	MM14892
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	STAG1 STAG2	4.46e-04	11	41	2	M27177
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	STAG1 STAG2	4.46e-04	11	41	2	MM14891
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	STAG1 STAG2	6.31e-04	13	41	2	M27661
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	PDPK1 PDPK2P	6.31e-04	13	41	2	MM15171
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	STAG1 STAG2	6.31e-04	13	41	2	MM15363
Pathway	BIOCARTA_PTDINS_PATHWAY	PDPK1 PDPK2P	9.65e-04	16	41	2	MM1454
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE	STAG1 STAG2	9.65e-04	16	41	2	M47870
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BPTF MFAP1 BRD8 GTF3C1 WEE1 ACLY PDPK1 BRD3 CHD7 STAG2	3.33e-07	774	55	10	15302935
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ATXN7L3 BPTF MFAP1 BRD8 ZZZ3 TELO2 WEE1 FAT3 ASCC1 APBA2 BRD3	1.16e-06	1116	55	11	31753913
Pubmed	The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.	PDPK1 PDPK2P	2.46e-06	2	55	2	15077109
Pubmed	Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.	STAG1 STAG2	2.46e-06	2	55	2	22415365
Pubmed	Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.	PDPK1 PDPK2P	2.46e-06	2	55	2	19716369
Pubmed	PDK1 Is Required for Maintenance of CD4+ Foxp3+ Regulatory T Cell Function.	PDPK1 PDPK2P	2.46e-06	2	55	2	33789982
Pubmed	Effects of inhibiting PDK‑1 expression in bone marrow mesenchymal stem cells on osteoblast differentiation in vitro.	PDPK1 PDPK2P	2.46e-06	2	55	2	33300048
Pubmed	STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.	STAG1 STAG2	2.46e-06	2	55	2	34648034
Pubmed	Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis.	PDPK1 PDPK2P	2.46e-06	2	55	2	36726025
Pubmed	STAG Mutations in Cancer.	STAG1 STAG2	2.46e-06	2	55	2	31421907
Pubmed	The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	32457586
Pubmed	T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	21074460
Pubmed	Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	31055616
Pubmed	Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.	STAG1 STAG2	2.46e-06	2	55	2	32778134
Pubmed	Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.	PDPK1 PDPK2P	2.46e-06	2	55	2	12855688
Pubmed	Structure-based design of PDK1 inhibitors.	PDPK1 PDPK2P	2.46e-06	2	55	2	22119465
Pubmed	Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.	PDPK1 PDPK2P	2.46e-06	2	55	2	12006370
Pubmed	Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta.	PDPK1 PDPK2P	2.46e-06	2	55	2	10075713
Pubmed	Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	17077298
Pubmed	3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.	PDPK1 PDPK2P	2.46e-06	2	55	2	17077284
Pubmed	Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.	PDPK1 PDPK2P	2.46e-06	2	55	2	14623982
Pubmed	Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.	STAG1 STAG2	2.46e-06	2	55	2	24324008
Pubmed	PDK1 regulates platelet activation and arterial thrombosis.	PDPK1 PDPK2P	2.46e-06	2	55	2	23444402
Pubmed	Fine tuning PDK1 activity by phosphorylation at Ser163.	PDPK1 PDPK2P	2.46e-06	2	55	2	16751192
Pubmed	α-SMA-Cre-mediated excision of PDK1 reveals an essential role of PDK1 in regulating morphology of cardiomyocyte and tumor progression in tissue microenvironment.	PDPK1 PDPK2P	2.46e-06	2	55	2	25601552
Pubmed	PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.	PDPK1 PDPK2P	2.46e-06	2	55	2	27339458
Pubmed	PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities.	PDPK1 PDPK2P	2.46e-06	2	55	2	27286918
Pubmed	The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism.	PDPK1 PDPK2P	2.46e-06	2	55	2	12420226
Pubmed	3-phosphoinositide-dependent kinase 1 deficiency perturbs Toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	17991746
Pubmed	Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	19246967
Pubmed	Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	20944007
Pubmed	Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	20978239
Pubmed	Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.	PDPK1 PDPK2P	2.46e-06	2	55	2	20051528
Pubmed	Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	21063107
Pubmed	Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.	STAG1 STAG2	2.46e-06	2	55	2	19822671
Pubmed	Co-Mutation of FAT3 and LRP1B in Lung Adenocarcinoma Defines a Unique Subset Correlated With the Efficacy of Immunotherapy.	FAT3 LRP1B	2.46e-06	2	55	2	35069585
Pubmed	Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	11877406
Pubmed	Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner.	PDPK1 PDPK2P	2.46e-06	2	55	2	23455320
Pubmed	Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.	STAG1 STAG2	2.46e-06	2	55	2	29649003
Pubmed	In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.	PDPK1 PDPK2P	2.46e-06	2	55	2	12912918
Pubmed	Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	16741145
Pubmed	PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport.	PDPK1 PDPK2P	2.46e-06	2	55	2	20511717
Pubmed	Conditional knockout of the PDK-1 gene in osteoblasts affects osteoblast differentiation and bone formation.	PDPK1 PDPK2P	2.46e-06	2	55	2	33377210
Pubmed	Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae.	STAG1 STAG2	2.46e-06	2	55	2	22715410
Pubmed	Threonine 34 phosphorylation by phosphoinositide-dependent protein kinase 1 facilitates dissociation of Akt from the plasma membrane.	PDPK1 PDPK2P	2.46e-06	2	55	2	25912234
Pubmed	Evaluation of approaches to generation of tissue-specific knock-in mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	16887794
Pubmed	The kinase PDK1 is essential for B-cell receptor mediated survival signaling.	PDPK1 PDPK2P	2.46e-06	2	55	2	23393571
Pubmed	Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.	STAG1 STAG2	2.46e-06	2	55	2	28430577
Pubmed	Deletion of PDK1 causes cardiac sodium current reduction in mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	25781322
Pubmed	STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.	STAG1 STAG2	2.46e-06	2	55	2	32467316
Pubmed	Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.	STAG1 STAG2	2.46e-06	2	55	2	32294612
Pubmed	Essential role of PDK1 in regulating endothelial cell migration.	PDPK1 PDPK2P	2.46e-06	2	55	2	17371830
Pubmed	In vivo role of the phosphate groove of PDK1 defined by knockin mutation.	PDPK1 PDPK2P	2.46e-06	2	55	2	16219676
Pubmed	Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.	STAG1 STAG2	2.46e-06	2	55	2	31495782
Pubmed	Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	17899170
Pubmed	Antitumor immunity and prognosis value elicited by FAT3 and LRP1B co-mutation in endometrial cancer.	FAT3 LRP1B	2.46e-06	2	55	2	38696842
Pubmed	Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	16923125
Pubmed	PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.	PDPK1 PDPK2P	2.46e-06	2	55	2	19423553
Pubmed	Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.	STAG1 STAG2	2.46e-06	2	55	2	27341316
Pubmed	Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.	PDPK1 PDPK2P	2.46e-06	2	55	2	12970179
Pubmed	Role of PDK1 in regulation of gastric acid secretion.	PDPK1 PDPK2P	2.46e-06	2	55	2	19088454
Pubmed	Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA and serotonin abundance in the amygdala.	PDPK1 PDPK2P	2.46e-06	2	55	2	19088455
Pubmed	Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.	PDPK1 PDPK2P	2.46e-06	2	55	2	12054753
Pubmed	Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	18514190
Pubmed	Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.	PDPK1 PDPK2P	2.46e-06	2	55	2	15531926
Pubmed	Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.	ZNF423 ZNF521	2.46e-06	2	55	2	12393497
Pubmed	Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis.	PDPK1 PDPK2P	2.46e-06	2	55	2	22108800
Pubmed	The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.	PDPK1 PDPK2P	2.46e-06	2	55	2	15116068
Pubmed	Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.	PDPK1 PDPK2P	2.46e-06	2	55	2	25645675
Pubmed	Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17.	PDPK1 PDPK2P	2.46e-06	2	55	2	15309345
Pubmed	Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development.	PDPK1 PDPK2P	2.46e-06	2	55	2	17027005
Pubmed	Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop.	PDPK1 PDPK2P	2.46e-06	2	55	2	12923190
Pubmed	Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.	STAG1 STAG2	2.46e-06	2	55	2	28691904
Pubmed	Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis.	PDPK1 PDPK2P	2.46e-06	2	55	2	17456549
Pubmed	Essential role of PDK1 in regulating cell size and development in mice.	PDPK1 PDPK2P	2.46e-06	2	55	2	12110585
Pubmed	Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.	PDPK1 PDPK2P	2.46e-06	2	55	2	17617409
Pubmed	Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.	PDPK1 PDPK2P	2.46e-06	2	55	2	26476238
Pubmed	The effect of PDK1 in maintaining immune cell development and function.	PDPK1 PDPK2P	2.46e-06	2	55	2	38795634
Pubmed	Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.	PDPK1 PDPK2P	2.46e-06	2	55	2	16563390
Pubmed	PDK1 Activity Regulates Proliferation, Invasion and Growth of Hemangiomas.	PDPK1 PDPK2P	2.46e-06	2	55	2	26202351
Pubmed	Deficiency of PDK1 in osteoclasts delays fracture healing and repair.	PDPK1 PDPK2P	2.46e-06	2	55	2	32626968
Pubmed	Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.	PDPK1 PDPK2P	7.36e-06	3	55	2	19703999
Pubmed	PDK1 plays a vital role on hematopoietic stem cell function.	PDPK1 PDPK2P	7.36e-06	3	55	2	28694518
Pubmed	Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis.	PDPK1 PDPK2P	7.36e-06	3	55	2	31578203
Pubmed	Serine 396 of PDK1 is required for maximal PKB activation.	PDPK1 PDPK2P	7.36e-06	3	55	2	18718528
Pubmed	The kinase PDK1 is critical for promoting T follicular helper cell differentiation.	PDPK1 PDPK2P	7.36e-06	3	55	2	33595435
Pubmed	Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass.	PDPK1 PDPK2P	7.36e-06	3	55	2	16642023
Pubmed	PDK1 is important lipid kinase for RANKL-induced osteoclast formation and function via the regulation of the Akt-GSK3β-NFATc1 signaling cascade.	PDPK1 PDPK2P	7.36e-06	3	55	2	32048762
Pubmed	Akt signaling is critical for memory CD8+ T-cell development and tumor immune surveillance.	PDPK1 PDPK2P	7.36e-06	3	55	2	28137869
Pubmed	Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.	PDPK1 PDPK2P	7.36e-06	3	55	2	16314505
Pubmed	Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.	PDPK1 PDPK2P	7.36e-06	3	55	2	16785309
Pubmed	PDK1 is a negative regulator of axon regeneration.	PDPK1 PDPK2P	7.36e-06	3	55	2	33579325
Pubmed	Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.	PDPK1 PDPK2P	7.36e-06	3	55	2	18184863
Pubmed	The inhibition of Akt-Pdpk1 interaction efficiently suppresses the growth of murine primary liver tumor cells.	PDPK1 PDPK2P	7.36e-06	3	55	2	27103434
Pubmed	Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch.	ZNF423 ZNF521	7.36e-06	3	55	2	24891617
Pubmed	Stage-specific requirement of kinase PDK1 for NK cells development and activation.	PDPK1 PDPK2P	7.36e-06	3	55	2	30622306
Pubmed	PDK1 plays a critical role in regulating cardiac function in mice and human.	PDPK1 PDPK2P	7.36e-06	3	55	2	21034549
Pubmed	Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.	PDPK1 PDPK2P	7.36e-06	3	55	2	19920149
Pubmed	Regulation of novel protein kinase C epsilon by phosphorylation.	PDPK1 PDPK2P	7.36e-06	3	55	2	11964154
Pubmed	Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.	STAG1 STAG2	7.36e-06	3	55	2	38742641
Interaction	MTA1 interactions	BPTF STAG1 ZNF423 PDPK1 ZNF521 BRD3 CHD7 STAG2	8.14e-07	283	54	8	int:MTA1
Interaction	C2CD4B interactions	FAT3 SCN4A APBA2 LRP1B	5.77e-06	44	54	4	int:C2CD4B
GeneFamily	Cohesin complex	STAG1 STAG2	1.01e-04	8	35	2	1060
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	CACNA1F BPTF MFAP1 GTF3C1 WEE1 ZNF423 ZDBF2 CHD7 JAKMIP2 STAG2	2.18e-06	595	54	10	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlas	kidney_e10.5_UretericTrunk_HoxB7_k-means-cluster#2_top-relative-expression-ranked_100	FAT3 CHD7	6.32e-05	5	54	2	gudmap_kidney_e10.5_UretericTrunk_HoxB7_k2_100
ToppCell	proximal-Hematologic-Natural_Killer_T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	APBA2 BRD3 ZDBF2 FYB1 JAKMIP2	4.24e-06	195	55	5	4d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCell	proximal-3-Hematologic-Natural_Killer_T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	APBA2 BRD3 ZDBF2 FYB1 JAKMIP2	4.24e-06	195	55	5	93093545bb23d2619ace029a52cffa1f673a0c2a
ToppCell	proximal-Hematologic-Natural_Killer_T\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	APBA2 BRD3 ZDBF2 FYB1 JAKMIP2	4.24e-06	195	55	5	3944e4800f5d904d4efa401ce8913ec0e0781211
Disease	Abnormality of head or neck	TMEM94 STAG2	3.28e-05	5	54	2	C4021817
Disease	serum gamma-glutamyl transferase measurement	PIK3AP1 BPTF ZZZ3 TRANK1 STAG1 RNF181 ADAM30 STKLD1	2.42e-04	914	54	8	EFO_0004532
Disease	Hypermetropia, Myopia	GRAMD1B BPTF CHD7 FYB1	4.02e-04	189	54	4	HP_0000540, HP_0000545
Disease	alcohol use disorder (implicated_via_orthology)	PDPK1 PDPK2P CTSL MAP4K2	4.52e-04	195	54	4	DOID:1574 (implicated_via_orthology)
Disease	neuroticism measurement, cognitive function measurement	ZZZ3 GTF3C1 PSEN2 STAG1 RIMS4 LRP1B	5.74e-04	566	54	6	EFO_0007660, EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
YDSEEEEEGLPMSYD	BRD3	561	Q15059
FSGFDPDDMDVDEDE	DNAJB5	121	O75953
YVSEMEDQPPSGECD	BRD8	1056	Q9H0E9
ETPEDYTLMVDEEGF	CASTOR1	46	Q8WTX7
DEEDFYQGSMECADE	ASCC1	31	Q8N9N2
IRYCPEDDSYLEGMD	APBA2	101	Q99767
EDDSYLEGMDCNGEE	APBA2	106	Q99767
NPGCDEDLYESMAAF	PIK3AP1	436	Q6ZUJ8
PEEMEDDDDDASYCT	BPTF	176	Q12830
GYCFTMIEEDDSGLP	BMPR1B	51	O00238
DETRDGFYMEDGDPS	CHD7	2281	Q9P2D1
VPPDDDFNTMGYCEE	GRAMD1B	236	Q3KR37
GYFFLDDTDPDSMKD	ATXN7L3	46	Q14CW9
EAMGDTFPDADADED	RLN3	61	Q8WXF3
TPSPEDCELETYDMF	MAP4K2	296	Q12851
DFLGSPELEVFCDME	ANGPTL7	151	O43827
TCYFLGSDMEAEEDP	CACNA1F	266	O60840
DADSGEYFFDRDPDM	KCND1	76	Q9NSA2
LDPFIGYDEDSMDSE	JAKMIP2	431	Q96AA8
DYAPMESSDEEDEEF	MFAP1	46	P55081
EYDCADGSDEMDCVT	LRP1B	3616	Q9NZR2
PGSTVMLCDYKFDDE	ODR4	351	Q5SWX8
EYFQDDMPESEECAS	DCAF11	516	Q8TEB1
MGDEVYDDVDTSDFP	FYB1	646	O15117
PAMSEDDEDCYGNVS	PDPK2P	336	Q6A1A2
GPEDMEEARECYLFA	PLA2G4F	736	Q68DD2
GYENPMQFEESDCDS	MAP3K13	931	O43283
FGPDAMEAPSECYDA	ADAM30	511	Q9UKF2
DEDDMEGDSFFDDPI	CEP43	246	O95684
SPKMEEEGEEEDYCT	DUSP29	21	Q68J44
CGFDDSEVAMSDYES	FAT3	4521	Q8TDW7
DMLCFVEDPTFGYED	SESN2	311	P58004
MDYSYDEDLDELCPV	NR5A1	1	Q13285
EESSEPLGEDDFEMF	SCN4A	1606	P35499
FPCMNSFDDEDAGDS	RIMS4	21	Q9H426
MASYFDEHDCEPSDP	RNF181	1	Q9P0P0
YLPAMSEDDEDCYGN	PDPK1	361	O15530
DSDLDSDDEFVPYDM	TELO2	486	Q9Y4R8
SDDEFVPYDMSGDRE	TELO2	491	Q9Y4R8
GMLDFDYVCSRDEPS	ACLY	511	P53396
EGIYFEPDCSSEDMD	CTSL	261	P07711
EPDDFRACLISMGYD	ACTN3	781	Q08043
DSCGEDMEASDYELE	WEE1	261	P30291
GMESDPYEAEDFVCD	TMEM94	536	Q12767
LATYPADGEMAEASC	STKLD1	511	Q8NE28
EFDEDSGDYPLTMAG	STAG2	151	Q8N3U4
PDSSYDYLEEMEACE	TMEM247	46	A6NEH6
EEDVDTSEPMYGCDI	ZNF521	876	Q96K83
DLEVSCEPDGFEMNF	ZDBF2	1736	Q9HCK1
PEMEEDSYDSFGEPS	PSEN2	321	P49810
MTEEFDEDSGDYPLT	STAG1	151	Q8WVM7
YDMVCGDIPFEQDEE	PIM3	236	Q86V86
MADGPDEYDTEAGCV	ZDHHC17	11	Q8IUH5
EDDVDASEPMYGCDI	ZNF423	876	Q2M1K9
DYFAEPECEFGQDEM	TRANK1	2636	O15050
DESPMAFYEPTLDCT	GTF3C1	2076	Q12789
EPPVYMDEDDDRSCF	ZZZ3	751	Q8IYH5