Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone phosphatase activity

EYA1 EYA2

1.69e-053482GO:0140789
GeneOntologyMolecularFunctionhistone H2AXY142 phosphatase activity

EYA1 EYA2

1.69e-053482GO:0140793
GeneOntologyMolecularFunctionmicrotubule plus-end binding

DST CLASP1 CLASP2

1.94e-0522483GO:0051010
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate phosphatase activity

INPP5D MTM1 MTMR2

3.66e-0527483GO:0034593
GeneOntologyMolecularFunctionphosphatidylinositol phosphate phosphatase activity

INPP5D MTM1 MTMR2

5.06e-0530483GO:0052866
GeneOntologyMolecularFunctionL-leucine binding

SESN2 SESN1

1.18e-047482GO:0070728
GeneOntologyMolecularFunctionhistone modifying activity

MED24 EYA1 EYA2 DOT1L TRIM37

2.18e-04229485GO:0140993
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

MTM1 MTMR2

3.07e-0411482GO:0052629
GeneOntologyMolecularFunctiondystroglycan binding

CLASP1 CLASP2

3.68e-0412482GO:0002162
GeneOntologyMolecularFunctionmyosin II binding

LLGL2 LLGL1

4.34e-0413482GO:0045159
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate phosphatase activity

MTM1 MTMR2

5.06e-0414482GO:0004438
GeneOntologyMolecularFunctionphosphatidylinositol monophosphate phosphatase activity

MTM1 MTMR2

5.82e-0415482GO:0052744
GeneOntologyMolecularFunctionphosphatase activity

INPP5D MTM1 MTMR2 EYA1 EYA2

6.12e-04287485GO:0016791
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

MTM1 MTMR2

6.65e-0416482GO:0106018
GeneOntologyMolecularFunctionmicrotubule binding

DST CLASP1 CAMSAP3 CLASP2 SPAG5

8.41e-04308485GO:0008017
GeneOntologyMolecularFunctionphosphoprotein phosphatase activity

MTM1 MTMR2 EYA1 EYA2

1.09e-03189484GO:0004721
GeneOntologyMolecularFunctioncalcium-activated cation channel activity

TRPM4 TMEM63C

1.91e-0327482GO:0005227
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

INPP5D MTM1 MTMR2 EYA1 EYA2

2.28e-03386485GO:0042578
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

TRPM4 TMEM63C

2.52e-0331482GO:0022839
GeneOntologyMolecularFunctiontubulin binding

DST CLASP1 CAMSAP3 CLASP2 SPAG5

3.55e-03428485GO:0015631
GeneOntologyMolecularFunctionSH3 domain binding

REPS1 INPP5D RAPGEF1

4.92e-03143483GO:0017124
GeneOntologyBiologicalProcessestablishment of spindle localization

LLGL2 LLGL1 CLASP1 CLASP2 EYA1 SPAG5

6.40e-0962486GO:0051293
GeneOntologyBiologicalProcessestablishment or maintenance of cell polarity

LLGL2 DST LLGL1 CLASP1 LAMA1 CAMSAP3 CLASP2 EYA1 SPAG5

6.91e-09257489GO:0007163
GeneOntologyBiologicalProcessestablishment of cell polarity

LLGL2 LLGL1 CLASP1 LAMA1 CAMSAP3 CLASP2 EYA1 SPAG5

7.07e-09177488GO:0030010
GeneOntologyBiologicalProcessspindle localization

LLGL2 LLGL1 CLASP1 CLASP2 EYA1 SPAG5

1.03e-0867486GO:0051653
GeneOntologyBiologicalProcessestablishment of spindle orientation

LLGL2 LLGL1 CLASP1 EYA1 SPAG5

7.03e-0846485GO:0051294
GeneOntologyBiologicalProcessestablishment or maintenance of bipolar cell polarity

LLGL2 LLGL1 LAMA1 CAMSAP3 EYA1

3.50e-0763485GO:0061245
GeneOntologyBiologicalProcessestablishment or maintenance of apical/basal cell polarity

LLGL2 LLGL1 LAMA1 CAMSAP3 EYA1

3.50e-0763485GO:0035088
GeneOntologyBiologicalProcessregulation of basement membrane organization

CLASP1 LAMA1 CLASP2

1.93e-0611483GO:0110011
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

LLGL2 DST LLGL1 CLASP1 FBXW5 CAMSAP3 CLASP2 EYA1 TRIM37 SPAG5

4.96e-067204810GO:0000226
GeneOntologyBiologicalProcessestablishment or maintenance of epithelial cell apical/basal polarity

LLGL2 LLGL1 LAMA1 CAMSAP3

9.99e-0658484GO:0045197
GeneOntologyBiologicalProcessmicrotubule anchoring

CLASP1 CAMSAP3 CLASP2

2.62e-0525483GO:0034453
GeneOntologyBiologicalProcesspositive regulation of transport

TRPM4 CLASP1 ABCA13 HGS MTMR2 XPO4 RAPGEF1 CACNA1I CLASP2 LILRA5 SPAG5

2.94e-0510814811GO:0051050
GeneOntologyBiologicalProcessphosphatidylinositol dephosphorylation

INPP5D MTM1 MTMR2

4.59e-0530483GO:0046856
GeneOntologyBiologicalProcesspositive regulation of basement membrane assembly involved in embryonic body morphogenesis

CLASP1 CLASP2

5.28e-055482GO:1904261
GeneOntologyBiologicalProcessregulation of basement membrane assembly involved in embryonic body morphogenesis

CLASP1 CLASP2

5.28e-055482GO:1904259
GeneOntologyBiologicalProcessnegative regulation of wound healing, spreading of epidermal cells

CLASP1 CLASP2

5.28e-055482GO:1903690
GeneOntologyBiologicalProcessbasement membrane assembly involved in embryonic body morphogenesis

CLASP1 CLASP2

5.28e-055482GO:2001197
GeneOntologyBiologicalProcessregulation of microtubule-based process

CLASP1 FBXW5 CAMSAP3 CLASP2 TRIM37 SPAG5

5.80e-05293486GO:0032886
GeneOntologyBiologicalProcessnegative regulation of microtubule depolymerization

CLASP1 CAMSAP3 CLASP2

9.42e-0538483GO:0007026
GeneOntologyBiologicalProcesspositive regulation of exocytosis

CLASP1 HGS CACNA1I CLASP2

1.12e-04107484GO:0045921
GeneOntologyBiologicalProcesscell-substrate junction assembly

DST CLASP1 CAMSAP3 CLASP2

1.16e-04108484GO:0007044
GeneOntologyBiologicalProcessregulation of microtubule depolymerization

CLASP1 CAMSAP3 CLASP2

1.27e-0442483GO:0031114
GeneOntologyBiologicalProcessmicrotubule-based process

LLGL2 DST LLGL1 CLASP1 FBXW5 CAMSAP3 CLASP2 EYA1 TRIM37 SPAG5

1.33e-0410584810GO:0007017
GeneOntologyBiologicalProcessbasement membrane organization

CLASP1 LAMA1 CLASP2

1.37e-0443483GO:0071711
GeneOntologyBiologicalProcessregulation of vesicle-mediated transport

CLASP1 ABCA13 LYPLAL1 HGS MTMR2 RAPGEF1 CACNA1I CLASP2

1.38e-04667488GO:0060627
GeneOntologyBiologicalProcessphospholipid dephosphorylation

INPP5D MTM1 MTMR2

1.46e-0444483GO:0046839
GeneOntologyBiologicalProcessestablishment of mitotic spindle localization

CLASP1 CLASP2 EYA1

1.46e-0444483GO:0040001
GeneOntologyBiologicalProcesscell-substrate junction organization

DST CLASP1 CAMSAP3 CLASP2

1.48e-04115484GO:0150115
GeneOntologyBiologicalProcessorganelle localization

LLGL2 LLGL1 CLASP1 MTM1 HGS CLASP2 EYA1 SPAG5

1.98e-04703488GO:0051640
GeneOntologyBiologicalProcessnegative regulation of microtubule polymerization or depolymerization

CLASP1 CAMSAP3 CLASP2

2.28e-0451483GO:0031111
GeneOntologyBiologicalProcesspositive regulation of extracellular matrix disassembly

CLASP1 CLASP2

2.36e-0410482GO:0090091
GeneOntologyBiologicalProcessestablishment of organelle localization

LLGL2 LLGL1 CLASP1 HGS CLASP2 EYA1 SPAG5

2.52e-04546487GO:0051656
GeneOntologyBiologicalProcessregulation of wound healing, spreading of epidermal cells

CLASP1 CLASP2

2.88e-0411482GO:1903689
GeneOntologyBiologicalProcesscell junction assembly

DST CLASP1 PKP3 GJD3 CAMSAP3 RAPGEF1 CLASP2

3.23e-04569487GO:0034329
GeneOntologyBiologicalProcessorganelle fission

CLASP1 FBXW5 CLASP2 ANAPC5 MIEF2 STAT2 SPAG5

3.30e-04571487GO:0048285
GeneOntologyBiologicalProcesscellular response to leucine starvation

SESN2 SESN1

3.45e-0412482GO:1990253
GeneOntologyBiologicalProcessbasement membrane assembly

CLASP1 CLASP2

3.45e-0412482GO:0070831
GeneOntologyBiologicalProcesscell cycle process

LLGL2 LLGL1 CLASP1 FBXW5 CAMSAP3 CLASP2 EYA1 DOT1L ANAPC5 TRIM37 SPAG5

3.79e-0414414811GO:0022402
GeneOntologyBiologicalProcessmesodermal cell fate specification

EYA1 EYA2

4.07e-0413482GO:0007501
GeneOntologyBiologicalProcesscellular response to L-leucine

SESN2 SESN1

4.07e-0413482GO:0071233
GeneOntologyBiologicalProcessregulation of response to reactive oxygen species

SESN2 SESN1

4.07e-0413482GO:1901031
GeneOntologyBiologicalProcesslocalization within membrane

LLGL2 LLGL1 LYPLAL1 PKP3 HGS CLASP2 SESN2 MIEF2

4.63e-04798488GO:0051668
GeneOntologyBiologicalProcessexocytosis

LLGL2 LLGL1 CLASP1 HGS CACNA1I CLASP2

4.87e-04434486GO:0006887
GeneOntologyBiologicalProcessmicrotubule depolymerization

CLASP1 CAMSAP3 CLASP2

4.88e-0466483GO:0007019
GeneOntologyBiologicalProcesspositive regulation of extracellular matrix assembly

CLASP1 CLASP2

5.46e-0415482GO:1901203
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

TRPM4 GJD3

5.46e-0415482GO:0086067
GeneOntologyBiologicalProcessembryonic body morphogenesis

CLASP1 CLASP2

5.46e-0415482GO:0010172
GeneOntologyBiologicalProcessregulation of microtubule polymerization

CLASP1 CAMSAP3 CLASP2

5.56e-0469483GO:0031113
GeneOntologyBiologicalProcessregulation of focal adhesion assembly

CLASP1 CAMSAP3 CLASP2

5.80e-0470483GO:0051893
GeneOntologyBiologicalProcessGolgi to plasma membrane transport

LLGL2 LLGL1 LYPLAL1

5.80e-0470483GO:0006893
GeneOntologyBiologicalProcessregulation of cell-substrate junction assembly

CLASP1 CAMSAP3 CLASP2

5.80e-0470483GO:0090109
GeneOntologyBiologicalProcessplatelet-derived growth factor receptor signaling pathway

HGS RAPGEF1 CLASP2

6.05e-0471483GO:0048008
GeneOntologyBiologicalProcessresponse to L-leucine

SESN2 SESN1

6.23e-0416482GO:0043201
GeneOntologyBiologicalProcessvesicle-mediated transport to the plasma membrane

LLGL2 LLGL1 LYPLAL1 HGS

6.83e-04172484GO:0098876
GeneOntologyBiologicalProcessnegative regulation of TOR signaling

MTM1 SESN2 SESN1

6.83e-0474483GO:0032007
GeneOntologyBiologicalProcessmorphogenesis of an epithelial sheet

CLASP1 LAMA1 CLASP2

6.83e-0474483GO:0002011
GeneOntologyBiologicalProcessregulation of cell-substrate junction organization

CLASP1 CAMSAP3 CLASP2

7.10e-0475483GO:0150116
GeneOntologyBiologicalProcessregulation of microtubule cytoskeleton organization

CLASP1 CAMSAP3 CLASP2 SPAG5

7.44e-04176484GO:0070507
GeneOntologyBiologicalProcessmicrotubule organizing center organization

CLASP1 FBXW5 CLASP2 TRIM37

7.92e-04179484GO:0031023
GeneOntologyBiologicalProcessepithelial cell-cell adhesion

PKP3 CAMSAP3

7.92e-0418482GO:0090136
GeneOntologyBiologicalProcessmitotic nuclear division

CLASP1 FBXW5 CLASP2 ANAPC5 SPAG5

8.16e-04316485GO:0140014
GeneOntologyBiologicalProcessregulation of organelle organization

CLASP1 MTM1 FBXW5 CAMSAP3 CLASP2 ANAPC5 TRIM37 MIEF2 STAT2 SPAG5

8.84e-0413424810GO:0033043
GeneOntologyBiologicalProcessmaintenance of cell polarity

DST LLGL1

9.81e-0420482GO:0030011
GeneOntologyBiologicalProcessregulation of gastrulation

CLASP1 CLASP2

9.81e-0420482GO:0010470
GeneOntologyBiologicalProcessregulation of extracellular matrix organization

CLASP1 LAMA1 CLASP2

9.87e-0484483GO:1903053
GeneOntologyBiologicalProcessnegative regulation of cytoskeleton organization

CLASP1 CAMSAP3 CLASP2 TRIM37

1.07e-03194484GO:0051494
GeneOntologyBiologicalProcessestablishment of epithelial cell apical/basal polarity

LAMA1 CAMSAP3

1.08e-0321482GO:0045198
GeneOntologyBiologicalProcesscell surface receptor signaling pathway via JAK-STAT

IL12B HGS DOT1L STAT2

1.15e-03198484GO:0007259
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

CLASP1 CAMSAP3 CLASP2

1.17e-0389483GO:1901880
GeneOntologyBiologicalProcessdephosphorylation

INPP5D MTM1 MTMR2 EYA1 EYA2

1.24e-03347485GO:0016311
GeneOntologyBiologicalProcessmesodermal cell fate commitment

EYA1 EYA2

1.30e-0323482GO:0001710
GeneOntologyBiologicalProcessmitotic sister chromatid segregation

CLASP1 CLASP2 ANAPC5 SPAG5

1.48e-03212484GO:0000070
GeneOntologyBiologicalProcessgastrulation

CLASP1 CLASP2 EYA1 EYA2

1.48e-03212484GO:0007369
GeneOntologyBiologicalProcessfocal adhesion assembly

CLASP1 CAMSAP3 CLASP2

1.50e-0397483GO:0048041
GeneOntologyBiologicalProcesslipid modification

INPP5D MTM1 MTMR2 SESN2

1.53e-03214484GO:0030258
GeneOntologyBiologicalProcessregulation of extracellular matrix disassembly

CLASP1 CLASP2

1.54e-0325482GO:0010715
GeneOntologyBiologicalProcessregulation of embryonic development

CLASP1 LAMA1 CLASP2

1.59e-0399483GO:0045995
GeneOntologyBiologicalProcesscell surface receptor signaling pathway via STAT

IL12B HGS DOT1L STAT2

1.59e-03216484GO:0097696
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

CLASP1 CAMSAP3 CLASP2

1.63e-03100483GO:0043242
GeneOntologyBiologicalProcesstissue morphogenesis

LLGL2 CLASP1 LAMA1 CAMSAP3 CLASP2 EYA1 EYA2

1.64e-03750487GO:0048729
GeneOntologyBiologicalProcessestablishment of apical/basal cell polarity

LAMA1 CAMSAP3

1.66e-0326482GO:0035089
GeneOntologyBiologicalProcesscell junction organization

DST CLASP1 PKP3 GJD3 CAMSAP3 MTMR2 RAPGEF1 CLASP2

1.69e-03974488GO:0034330
GeneOntologyBiologicalProcessregulation of cellular localization

IL12B TRPM4 LYPLAL1 MTMR2 XPO4 CLASP2 SESN2 MIEF2 SPAG5

1.70e-031212489GO:0060341
GeneOntologyBiologicalProcessregulation of protein depolymerization

CLASP1 CAMSAP3 CLASP2

1.88e-03105483GO:1901879
GeneOntologyBiologicalProcessestablishment of monopolar cell polarity

LAMA1 CAMSAP3

1.93e-0328482GO:0061162
GeneOntologyBiologicalProcesswound healing, spreading of epidermal cells

CLASP1 CLASP2

1.93e-0328482GO:0035313
GeneOntologyBiologicalProcessregulation of microtubule polymerization or depolymerization

CLASP1 CAMSAP3 CLASP2

2.03e-03108483GO:0031110
GeneOntologyBiologicalProcessregulation of extracellular matrix assembly

CLASP1 CLASP2

2.07e-0329482GO:1901201
GeneOntologyBiologicalProcessregulation of cardiac conduction

TRPM4 GJD3

2.07e-0329482GO:1903779
GeneOntologyBiologicalProcessestablishment or maintenance of monopolar cell polarity

LAMA1 CAMSAP3

2.07e-0329482GO:0061339
GeneOntologyBiologicalProcessregulation of exocytosis

CLASP1 HGS CACNA1I CLASP2

2.09e-03233484GO:0017157
GeneOntologyBiologicalProcesspolarized epithelial cell differentiation

LAMA1 CAMSAP3

2.21e-0330482GO:0030859
GeneOntologyBiologicalProcessregulation of establishment or maintenance of cell polarity

LLGL2 LLGL1

2.21e-0330482GO:0032878
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

LLGL2 LLGL1 EYA1

2.37e-03114483GO:0008593
GeneOntologyCellularComponentmicrotubule end

DST CLASP1 CAMSAP3 CLASP2 SPAG5

2.72e-0838495GO:1990752
GeneOntologyCellularComponentmicrotubule plus-end

DST CLASP1 CLASP2 SPAG5

5.23e-0728494GO:0035371
GeneOntologyCellularComponentcortical cytoskeleton

LLGL2 LLGL1 CLASP1 INPP5D CLASP2

1.27e-05129495GO:0030863
GeneOntologyCellularComponentcortical microtubule cytoskeleton

CLASP1 CLASP2

5.36e-055492GO:0030981
GeneOntologyCellularComponentbasal cortex

CLASP1 CLASP2

1.12e-047492GO:0045180
GeneOntologyCellularComponentcell cortex

LLGL2 DST LLGL1 CLASP1 INPP5D CLASP2

2.20e-04371496GO:0005938
GeneOntologyCellularComponentGATOR2 complex

SESN2 SESN1

3.50e-0412492GO:0061700
GeneOntologyCellularComponentanchoring junction

LLGL2 DST LLGL1 CLASP1 PKP3 GJD3 LAMA1 CAMSAP3 CLASP2

3.87e-04976499GO:0070161
GeneOntologyCellularComponentcell-cell junction

LLGL2 DST LLGL1 PKP3 GJD3 LAMA1 CAMSAP3

4.27e-04591497GO:0005911
GeneOntologyCellularComponentSeh1-associated complex

SESN2 SESN1

6.33e-0416492GO:0035859
GeneOntologyCellularComponentkinetochore microtubule

CLASP1 CLASP2

1.21e-0322492GO:0005828
GeneOntologyCellularComponentadherens junction

LLGL2 LLGL1 PKP3 CAMSAP3

1.52e-03212494GO:0005912
GeneOntologyCellularComponentsodium channel complex

TRPM4 CACNA1I

2.10e-0329492GO:0034706
DomainPA26

SESN2 SESN1

1.86e-053472PF04636
DomainSestrin

SESN2 SESN1

1.86e-053472IPR006730
DomainAhpD-like

SESN2 SESN1

1.86e-053472IPR029032
Domain-

SESN2 SESN1

1.86e-0534721.20.1290.10
Domain-

CLASP1 PKP3 XPO4 CLASP2 ZYG11B BTAF1

1.88e-052224761.25.10.10
DomainLLGL

LLGL2 LLGL1

3.71e-054472PF08366
DomainEYA_fam

EYA1 EYA2

3.71e-054472IPR028472
DomainEYA_dom

EYA1 EYA2

3.71e-054472IPR006545
DomainLethal2_giant

LLGL2 LLGL1

3.71e-054472IPR000664
DomainCLASP_N

CLASP1 CLASP2

3.71e-054472PF12348
DomainCLASP_N_dom

CLASP1 CLASP2

3.71e-054472IPR024395
DomainLLGL2

LLGL2 LLGL1

3.71e-054472IPR013577
DomainARM-like

CLASP1 PKP3 XPO4 CLASP2 ZYG11B BTAF1

5.64e-05270476IPR011989
DomainARM-type_fold

CLASP1 PKP3 XPO4 CLASP2 ZYG11B BTAF1

1.96e-04339476IPR016024
DomainHEAT

CLASP1 CLASP2 BTAF1

2.39e-0448473PF02985
DomainHEAT

CLASP1 CLASP2 BTAF1

4.18e-0458473IPR000357
DomainPPASE_MYOTUBULARIN

MTM1 MTMR2

5.53e-0414472PS51339
DomainMyotubularin_fam

MTM1 MTMR2

5.53e-0414472IPR030564
DomainMyotub-related

MTM1 MTMR2

5.53e-0414472PF06602
DomainMyotubularin-like_Pase_dom

MTM1 MTMR2

5.53e-0414472IPR010569
DomainHEAT_REPEAT

CLASP1 CLASP2 BTAF1

7.26e-0470473PS50077
DomainGRAM

MTM1 MTMR2

7.27e-0416472SM00568
DomainGRAM

MTM1 MTMR2

1.39e-0322472PF02893
DomainGRAM

MTM1 MTMR2

1.39e-0322472IPR004182
DomainSpectrin/alpha-actinin

SESTD1 DST

2.93e-0332472IPR018159
DomainSPEC

SESTD1 DST

2.93e-0332472SM00150
DomainPTPc_motif

MTM1 MTMR2

9.68e-0359472SM00404
DomainTyr_Pase_cat

MTM1 MTMR2

9.68e-0359472IPR003595
PathwayREACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING

CLASP1 CLASP2

2.52e-048432M27351
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

INPP5D MTM1 MTMR2

3.66e-0446433M48317
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE

MTM1 MTMR2

4.03e-0410432MM14644
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

INPP5D MTM1 MTMR2

4.42e-0449433M40046
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE

MTM1 MTMR2

4.91e-0411432M655
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

INPP5D MTM1 MTMR2

5.57e-0453433M662
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

MTM1 HGS LRRC1 CAMSAP3 MTMR2 XPO4 CLASP2 ZYG11B EYA1 EYA2

1.69e-061049491027880917
Pubmed

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.

CLASP1 CLASP2

1.94e-06249216914514
Pubmed

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.

SESN2 SESN1

1.94e-06249220203043
Pubmed

Expression of the neuropathy-associated MTMR2 gene rescues MTM1-associated myopathy.

MTM1 MTMR2

1.94e-06249228934386
Pubmed

Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.

CLASP1 CLASP2

1.94e-06249210899121
Pubmed

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.

SESN2 SESN1

1.94e-06249235771919
Pubmed

Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.

CLASP1 CLASP2

1.94e-06249212837247
Pubmed

The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration.

LLGL2 LLGL1

1.94e-06249222219375
Pubmed

IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene.

IL12B STAT2

1.94e-06249215611252
Pubmed

Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.

SESN2 SESN1

1.94e-06249231026186
Pubmed

[A study of recombinant human sestrin 1 and sestrin 2 proteins produced in a prokaryotic system].

SESN2 SESN1

1.94e-06249228707664
Pubmed

Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.

LLGL2 LLGL1

1.94e-06249223110097
Pubmed

Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.

CLASP1 CLASP2

1.94e-06249216866869
Pubmed

Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.

CLASP1 CLASP2

1.94e-06249219701196
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

DST PKP3 CLASP2 SPAG5

1.95e-066349429162697
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

LLGL2 DST LLGL1 HGS LRRC1 MTMR2 RASAL2

2.01e-0642149736976175
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

DST CLASP1 HGS CLASP2 ANAPC5 TRIM37 RASAL2

2.94e-0644649724255178
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

LLGL2 DST LLGL1 CAMSAP3 BTAF1 ANAPC5 RASAL2 SPAG5

3.27e-0665049838777146
Pubmed

CLIPs and CLASPs and cellular dynamics.

CLASP1 CLASP2

5.83e-06349215928712
Pubmed

A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.

EYA1 EYA2

5.83e-0634929020840
Pubmed

Six and Eya expression during human somitogenesis and MyoD gene family activation.

EYA1 EYA2

5.83e-06349212500905
Pubmed

CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.

CLASP1 CLASP2

5.83e-06349228285824
Pubmed

Sestrins are evolutionarily conserved mediators of exercise benefits.

SESN2 SESN1

5.83e-06349231929512
Pubmed

Eyes absent represents a class of protein tyrosine phosphatases.

EYA1 EYA2

5.83e-06349214628052
Pubmed

Sestrin1, 2, and 3 are dispensable for female fertility in mice.

SESN2 SESN1

5.83e-06349238297375
Pubmed

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.

CLASP1 CLASP2

5.83e-06349217543864
Pubmed

Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice.

MTM1 MTMR2

5.83e-06349228589938
Pubmed

Circulating Sestrin Levels Are Increased in Hypertension Patients.

SESN2 SESN1

5.83e-06349232626541
Pubmed

Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function.

EYA1 EYA2

5.83e-0634929342347
Pubmed

Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.

SESN2 SESN1

5.83e-06349231073887
Pubmed

CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.

CLASP1 CLASP2

5.83e-06349216824950
Pubmed

Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.

EYA1 EYA2

5.83e-06349219497856
Pubmed

CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

CLASP1 CLASP2

5.83e-06349222307330
Pubmed

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.

SESN2 SESN1

5.83e-06349212607115
Pubmed

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.

SESN2 SESN1

5.83e-06349231857853
Pubmed

The functions and roles of sestrins in regulating human diseases.

SESN2 SESN1

5.83e-06349234979914
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

SEPSECS CLASP1 PKP3 MTM1 LRRC1 MTMR2 XPO4 EYA1 EYA2

7.67e-0697449928675297
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

DST CLASP1 CLASP2 RASAL2 SPAG5

1.15e-0520949536779422
Pubmed

Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.

MTM1 MTMR2

1.16e-05449212847286
Pubmed

Functional redundancy in the myotubularin family.

MTM1 MTMR2

1.16e-05449211846405
Pubmed

SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells.

CLASP1 CLASP2

1.16e-05449233587225
Pubmed

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.

SESN2 SESN1

1.16e-05449222958918
Pubmed

Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

LLGL2 LLGL1

1.16e-05449212725730
Pubmed

CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.

CLASP1 SPAG5

1.16e-05449220852589
Pubmed

Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases.

MTM1 MTMR2

1.16e-05449212925573
Pubmed

Endosomal phosphoinositides and human diseases.

MTM1 MTMR2

1.16e-05449218429927
Pubmed

Misexpression of the eyes absent family triggers the apoptotic program.

EYA1 EYA2

1.16e-05449211700312
Pubmed

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.

SESN2 SESN1

1.16e-05449215105503
Pubmed

The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.

MED24 LRRC1 ANAPC5 SESN1

1.33e-0510249437024974
Pubmed

Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.

IL12B INPP5D LILRA5 STAT2

1.93e-0511249420331378
Pubmed

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.

SESN2 SESN1

1.94e-05549218692468
Pubmed

Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.

CLASP1 CLASP2

1.94e-05549211290329
Pubmed

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.

CLASP1 CLASP2

1.94e-05549215631994
Pubmed

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.

CLASP1 CLASP2

1.94e-05549217113391
Pubmed

Eyes absent: a gene family found in several metazoan phyla.

EYA1 EYA2

1.94e-0554929195991
Pubmed

Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.

CLASP1 CLASP2

1.94e-05549227378169
Pubmed

Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode.

EYA1 EYA2

1.94e-0554929006082
Pubmed

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.

CLASP1 CLASP2

1.94e-05549224859005
Pubmed

Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.

CLASP1 CLASP2

1.94e-05549223940118
Pubmed

Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.

EYA1 EYA2

1.94e-05549210490620
Pubmed

Sestrin2 is a leucine sensor for the mTORC1 pathway.

SESN2 SESN1

1.94e-05549226449471
Pubmed

NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.

IL12B STAT2

1.94e-05549221383239
Pubmed

A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.

MTM1 MTMR2

1.94e-0554928640223
Pubmed

PtdIns5P regulation through evolution: roles in membrane trafficking?

MTM1 MTMR2

2.91e-05649218774718
Pubmed

Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.

EYA1 EYA2

2.91e-05649220956555
Pubmed

An EB1-binding motif acts as a microtubule tip localization signal.

DST CLASP2

2.91e-05649219632184
Pubmed

EYA4, a novel vertebrate gene related to Drosophila eyes absent.

EYA1 EYA2

2.91e-0564929887327
Pubmed

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

SESN2 SESN1

4.07e-05749225259925
Pubmed

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.

SESN2 SESN1

4.07e-05749231929511
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

DST LLGL1 REPS1 CLASP1 HGS SPAG5

5.16e-0547249638943005
Pubmed

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.

LLGL2 LLGL1

5.42e-05849223397623
Pubmed

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

SESN2 SESN1

5.42e-05849223274085
Pubmed

Differential effects of IFN-β on IL-12, IL-23, and IL-10 expression in TLR-stimulated dendritic cells.

IL12B STAT2

5.42e-05849226059829
Pubmed

The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood.

EYA1 EYA2

6.96e-05949237181748
Pubmed

Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo.

EYA1 EYA2

6.96e-05949217098221
Pubmed

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

CLASP1 INPP5D CLASP2

7.29e-055749329089450
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SESTD1 SEPSECS CLASP1 CAMSAP3 XPO4 CLASP2 ZYG11B RASAL2 SPAG5

8.35e-05132149927173435
Pubmed

Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.

MTM1 MTMR2

8.69e-05104929736772
Pubmed

ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.

CLASP1 CLASP2

8.69e-051049218854161
Pubmed

EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.

CLASP1 CLASP2

8.69e-051049223001180
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SEPSECS CLASP1 PKP3 FBXW5 CLASP2 ANAPC5 TRIM37 STAT2

9.33e-05103849826673895
Pubmed

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

IL12B STAT2

1.06e-041149219169254
Pubmed

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

SESN2 SESN1

1.27e-041249225263562
Pubmed

Bioinformatics and cellular signaling.

SESTD1 INPP5D RAPGEF1 STAT2

1.28e-0418249415102471
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TRPM4 LLGL2 DST REPS1 RAPGEF1 CLASP2 BTAF1 DOT1L

1.44e-04110549835748872
Pubmed

NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.

LAMA1 TRIM37

1.50e-041349228416489
Pubmed

BMP4 is essential for lens induction in the mouse embryo.

EYA1 EYA2

1.50e-04134929851982
Pubmed

Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation.

HGS CLASP2 ANAPC5

2.00e-048049334831298
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TRPM4 PKP3 LRRC1 CAMSAP3 TMEM63C CLASP2 BTAF1 INTS8 SESN1

2.06e-04148949928611215
Pubmed

The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.

INPP5D HGS RAPGEF1

2.08e-048149320697350
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

MED24 TRPM4 DST REPS1 CLASP1 CAMSAP3 CLASP2 INTS8 ANAPC5

2.14e-04149749931527615
Pubmed

Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.

LLGL2 LLGL1

2.30e-041649215037549
Pubmed

Regulation of mouse lens fiber cell development and differentiation by the Maf gene.

EYA1 EYA2

2.61e-041749210603348
Pubmed

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4.

EYA1 EYA2

2.93e-041849219027001
Pubmed

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

IL12B STAT2

3.27e-041949220953190
Pubmed

MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.

LLGL2 LLGL1

3.27e-041949219666823
Pubmed

Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development.

LLGL2 LLGL1

3.64e-042049221606200
Pubmed

Proximity interactions among centrosome components identify regulators of centriole duplication.

CLASP1 TRIM37 SPAG5

3.97e-0410149324613305
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SESTD1 DST REPS1 MTM1 MTMR2 INTS8 TRIM37 RASAL2

3.98e-04128549835914814
Pubmed

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.

EYA1 EYA2

4.01e-042149212072567
Cytoband6p12.1

DST LRRC1

5.77e-04334926p12.1
GeneFamilyEYA transcriptional coactivator and phosphatases

EYA1 EYA2

1.82e-0543221044
GeneFamilyMembrane associated guanylate kinases|PDZ domain containing|Scribble complex

LLGL2 LLGL1

1.82e-0543221224
GeneFamilyPhosphoinositide phosphatases

INPP5D MTM1 MTMR2

2.41e-05323231079
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTM1 MTMR2

3.14e-0415322903
GeneFamilyWD repeat domain containing

LLGL2 LLGL1 FBXW5

1.09e-02262323362
GeneFamilySH2 domain containing

INPP5D STAT2

1.37e-02101322741
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LLGL2 CLASP1 LAMA1 EYA1 CCDC148

2.04e-061894957eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LLGL2 CLASP1 LAMA1 EYA1 CCDC148

2.04e-06189495975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

LLGL2 DST HGS TRIM37 RASAL2

2.31e-0619449588db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

LLGL2 DST HGS TRIM37 RASAL2

2.31e-06194495a71728202493d4858342ea2756ea281cd0d99a3a
ToppCelldroplet-Lung-nan-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B SEPSECS PAPOLB SPAG5

2.36e-0515249477b319f594d5e4df29034bbf69c7490076f89dd3
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LLGL2 PKP3 LRRC1 EYA1

2.68e-051574949665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DST HGS TRIM37 RASAL2

3.57e-051694946614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DST HGS TRIM37 RASAL2

3.57e-05169494665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PKP3 FBXW5 BTAF1 EYA2

4.09e-05175494711ace94fa9a763c6ae48171a690953f25deebe4
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-DC2|lymph-node_spleen / Manually curated celltypes from each tissue

TRPM4 DST LAMA1 LILRA5

4.18e-0517649472a3bbab0540ae3e3c94b9573cdb9298a024dbc4
ToppCellControl-Epithelial_alveolar-AT_1-AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LLGL2 PKP3 LRRC1 EYA1

4.37e-051784941817bc520f3d23da8c0fa09bba50ae703a820cb1
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D175|Adult / Lineage, Cell type, age group and donor

LLGL2 DST LRRC1 RASAL2

5.07e-0518549432b4e68e551d435a732f253f6ad83408c759a642
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DST GAL3ST1 ABCA13 SPAG5

5.40e-0518849414e120b20e76baa07b6510a94f0c2dcdfdd52357
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DST GAL3ST1 ABCA13 SPAG5

5.51e-05189494443359d90fafae0c1de6bdcce9e8c95df6ea4de8
ToppCellfacs-Skin-Anagen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKP3 CAMSAP3 ANAPC5 SESN1

5.63e-05190494888ded899f0513d41bf655896d59ae8ef74e0978
ToppCellfacs-Skin-Anagen-3m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKP3 CAMSAP3 ANAPC5 SESN1

5.63e-051904943466cebab16964e94da130d0673fa32e7d90b5ed
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 TMEM63C EYA1 EYA2

6.10e-05194494e0228f593c3493175962a4817500d4337ddc4e88
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LLGL2 GAL3ST1 PKP3 CAMSAP3

6.10e-0519449420f81f457ab0a404600effe8beb91fe73d1cfc10
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 PKP3 CAMSAP3 SESN1

6.10e-051944945d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 TMEM63C EYA1 EYA2

6.22e-05195494e7230a849ea31e6eef9bc6f5468938499450582d
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA1 EYA1 EYA2 CCDC148

6.35e-05196494a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell3'-Broncho-tracheal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DST ABCA13 PKP3 EYA2

6.47e-051974945d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

LLGL2 PKP3 LRRC1 EYA1

6.60e-05198494b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell3'-Broncho-tracheal-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DST ABCA13 PKP3 EYA2

6.60e-05198494aa6e7218ee6230902854e66c444b544218b30c0e
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 TMEM63C EYA1 EYA2

6.60e-0519849419d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCellTCGA-Endometrium-Primary_Tumor|TCGA-Endometrium / Sample_Type by Project: Shred V9

LLGL2 PKP3 CAMSAP3 SPAG5

6.86e-052004941cbb62df4ea1631fef8497e1702175605d0869e7
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma|TCGA-Endometrium / Sample_Type by Project: Shred V9

LLGL2 PKP3 CAMSAP3 SPAG5

6.86e-05200494e3ad8d592686a5d1e1fb8dd05c2f00eac4c5738f
Diseasekidney cancer (implicated_via_orthology)

LLGL2 LLGL1 LRRC1

6.61e-0711483DOID:263 (implicated_via_orthology)
Diseaseneuroblastoma (implicated_via_orthology)

LLGL2 LLGL1

2.58e-055482DOID:769 (implicated_via_orthology)
Diseaseeye disease (implicated_via_orthology)

EYA1 EYA2

3.87e-056482DOID:5614 (implicated_via_orthology)
Diseasebranchiootorenal syndrome (implicated_via_orthology)

EYA1 EYA2

5.41e-057482DOID:14702 (implicated_via_orthology)
Diseasecentronuclear myopathy X-linked (implicated_via_orthology)

MTM1 MTMR2

9.26e-059482DOID:0111225 (implicated_via_orthology)
Diseasecarcinoma (implicated_via_orthology)

LLGL2 LLGL1 LRRC1

1.57e-0464483DOID:305 (implicated_via_orthology)
Diseasecup-to-disc ratio measurement

SESTD1 LYPLAL1 RAPGEF1 EYA1 EYA2

6.57e-04430485EFO_0006939
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

MTM1 MTMR2

6.99e-0424482DOID:10595 (implicated_via_orthology)
Diseasegamma-linolenic acid measurement

FADS1 DOT1L

6.99e-0424482EFO_0007762
Diseasebrain cancer (implicated_via_orthology)

LLGL2 LLGL1

8.21e-0426482DOID:1319 (implicated_via_orthology)
Diseasecorpus callosum mid-anterior volume measurement

SEPSECS GAL3ST1

8.86e-0427482EFO_0010297
Diseasecancer (implicated_via_orthology)

LLGL2 DST LLGL1 LRRC1

9.46e-04268484DOID:162 (implicated_via_orthology)
Diseaselysophosphatidylcholine 18:2 measurement

FADS1 EYA2

9.53e-0428482EFO_0010361
Diseaselysophosphatidylethanolamine 20:4 measurement

FADS1 CACNA1I

1.02e-0329482EFO_0010370
DiseaseColorectal Neoplasms

FADS1 ABCA13 LAMA1 SESN2

1.07e-03277484C0009404
Diseaselysophosphatidylcholine 20:4 measurement

FADS1 EYA2

1.25e-0332482EFO_0010363
Diseaseposterior thigh muscle fat infiltration measurement

EYA1 EYA2

1.49e-0335482EFO_0020934
Diseasecerebrospinal fluid clusterin measurement

DST ABCA13

1.49e-0335482EFO_0007657
Diseaserheumatoid arthritis, Crohn's disease

IL12B FADS1

1.75e-0338482EFO_0000384, EFO_0000685
Diseasecognitive function measurement, self reported educational attainment

MTMR2 CACNA1I BTAF1 TRIM37

2.64e-03355484EFO_0004784, EFO_0008354
Diseasemyopathy (implicated_via_orthology)

MTM1 MTMR2

2.79e-0348482DOID:423 (implicated_via_orthology)
Diseaseglycerophospholipid measurement

FADS1 GAL3ST1

2.90e-0349482EFO_0007630

Protein segments in the cluster

PeptideGeneStartEntry
VSTLWLHLLLKATET

ADCK2

126

Q7Z695
NDLSDWSIKILDHSL

CCDC148

186

Q8NFR7
EDWSLEKSTHNLLSL

ABCA13

2011

Q86UQ4
ELQLDWATLSLEKLL

DOT1L

606

Q8TEK3
ALTSLEHKLLFWVDT

CAMSAP3

161

Q9P1Y5
HLKWDLDILEKSLSV

INTS8

91

Q75QN2
LSLLDDSSLHLWEIV

LLGL1

91

Q15334
DLLHWKHSLSELIDI

ANAPC5

406

Q9UJX4
LAITHEILLSKAEWS

PAPOLB

346

Q9NRJ5
VEIDNLWISSKLLSH

KIAA0100

66

Q14667
FILTEEGDHKLSWTL

LILRA5

171

A6NI73
LLDDNSLHLWSLKVK

LLGL2

91

Q6P1M3
HGILLEWLAVADTSK

LRIT2

376

A6NDA9
LDELLAWLTHTEGLL

DST

6386

Q03001
VNVSTESKLLWLHSL

TMEM63C

176

Q9P1W3
VKIWSNDLTISLLHS

FBXW5

116

Q969U6
IWDLDETIIVFHSLL

EYA1

326

Q99502
DSWLTLALKALSLIH

EYA1

476

Q99502
LHSLLWEVVSQLDKG

RASAL2

576

Q9UJF2
SNLESTHWLEHIKLI

MTMR2

381

Q13614
LLLLHKKEDGIWSTD

IL12B

101

P29460
ESIGALLHLKDLWLD

LRRC1

191

Q9BTT6
DESLVLLKDLLCWEL

GAL3ST1

256

Q99999
LWDALLELDDLTAST

BTAF1

476

O14981
LWLDSVSLIIKDSLE

CACNA1I

1801

Q9P0X4
LAEVLQWLLHATSKE

C4orf17

196

Q53FE4
SALLSVAELGHLLWK

GJD3

201

Q8N144
IIHSLKESGQLWLDA

FADS1

426

O60427
HELSKTELDILKLWI

LYPLAL1

211

Q5VWZ2
ELEALTDLWLTHSLK

EYA2

416

O00167
TDLWLTHSLKALNLI

EYA2

421

O00167
DSWKELSLLKATPHL

MIEF2

66

Q96C03
LLKTGEHTWSLAELI

SESN2

181

P58004
HLLDLKDRSSIENLW

TRIM37

621

O94972
LLKAEEHSWSLAELV

SESN1

186

Q9Y6P5
SWVLISKELISLLHL

SPAG5

506

Q96R06
SKLPILELSHIWELS

REPS1

316

Q96D71
WLDKILELVHDHLKD

STAT2

556

P52630
LEHLEDHQDKLLLWS

LAMA1

1831

P25391
ALLHIAKLEEASSWT

MED24

176

O75448
LSEKEWLEILKHSLQ

INPP5D

456

Q92835
EWLSELLDALLKTHI

SESTD1

511

Q86VW0
SLGVWEEHFKTILLL

CLASP1

1336

Q7Z460
WDEHFKTILLLLLET

CLASP2

1096

O75122
ILWNLSSSDHLKDRL

PKP3

426

Q9Y446
SLLDDLHSAILKWPT

ZYG11B

626

Q9C0D3
LLESWLTLVQDDKHF

XPO4

406

Q9C0E2
LESTHWLEHIKLVLT

MTM1

341

Q13496
SDHLAEEALWELSLK

RAPGEF1

1046

Q13905
LLDKATSQLLLETDW

HGS

11

O14964
WDESTLELFLHELAI

SEPSECS

46

Q9HD40
LLTWESVHKENFLLA

TRPM4

1121

Q8TD43