Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	organelle envelope	RANBP2 PGS1 ACADM VPS13C CYP27A1 TMEM135 TWNK BCHE NUP42 SQOR SLC25A51 SIRT4 ACSL1 SLC44A1 ABCB10 SLC25A40 PIK3C2G MRPS25 SUN5 CPNE1 PRKCA SLC25A52	4.45e-05	1435	126	22	GO:0031967
GeneOntologyCellularComponent	mitochondrial membrane	PGS1 ACADM VPS13C CYP27A1 TMEM135 TWNK SQOR SLC25A51 SIRT4 ACSL1 SLC44A1 ABCB10 SLC25A40 MRPS25 PRKCA SLC25A52	6.59e-05	866	126	16	GO:0031966
GeneOntologyCellularComponent	mitochondrial envelope	PGS1 ACADM VPS13C CYP27A1 TMEM135 TWNK SQOR SLC25A51 SIRT4 ACSL1 SLC44A1 ABCB10 SLC25A40 MRPS25 PRKCA SLC25A52	1.20e-04	912	126	16	GO:0005740
GeneOntologyCellularComponent	extracellular matrix	COL11A1 SFTPD ITIH2 ITIH3 EGFL6 LGALS4 PLXDC2 MMP8 MMP10 MMP12 CTSH TNXB	6.18e-04	656	126	12	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL11A1 SFTPD ITIH2 ITIH3 EGFL6 LGALS4 PLXDC2 MMP8 MMP10 MMP12 CTSH TNXB	6.34e-04	658	126	12	GO:0030312
Domain	DAPK1	DAPK2 DAPK1 DAPK3	2.79e-07	3	123	3	IPR020676
Domain	GPX_AS	GPX3 GPX5 GPX6	9.57e-06	7	123	3	IPR029759
Domain	GLUTATHIONE_PEROXID_2	GPX3 GPX5 GPX6	1.52e-05	8	123	3	PS00763
Domain	GLUTATHIONE_PEROXID_1	GPX3 GPX5 GPX6	1.52e-05	8	123	3	PS00460
Domain	Glutathione_peroxidase	GPX3 GPX5 GPX6	1.52e-05	8	123	3	IPR000889
Domain	GLUTATHIONE_PEROXID_3	GPX3 GPX5 GPX6	1.52e-05	8	123	3	PS51355
Domain	GPX_CS	GPX3 GPX5 GPX6	1.52e-05	8	123	3	IPR029760
Domain	GSHPx	GPX3 GPX5 GPX6	1.52e-05	8	123	3	PF00255
Domain	Pept_M10A_Zn_BS	MMP8 MMP10 MMP12	1.20e-04	15	123	3	IPR021158
Domain	Hemopexin_CS	MMP8 MMP10 MMP12	1.77e-04	17	123	3	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP8 MMP10 MMP12	2.12e-04	18	123	3	IPR016293
Domain	PG_binding_1	MMP8 MMP10 MMP12	2.93e-04	20	123	3	PF01471
Domain	Peptidoglycan-bd-like	MMP8 MMP10 MMP12	2.93e-04	20	123	3	IPR002477
Domain	-	COL11A1 FAT3 ADGRV1 LGALS4 ADGRG6	4.12e-04	95	123	5	2.60.120.200
Domain	Hemopexin-like_dom	MMP8 MMP10 MMP12	4.48e-04	23	123	3	IPR000585
Domain	Hemopexin-like_repeat	MMP8 MMP10 MMP12	4.48e-04	23	123	3	IPR018487
Domain	HEMOPEXIN	MMP8 MMP10 MMP12	4.48e-04	23	123	3	PS00024
Domain	-	MMP8 MMP10 MMP12	4.48e-04	23	123	3	2.110.10.10
Domain	HEMOPEXIN_2	MMP8 MMP10 MMP12	4.48e-04	23	123	3	PS51642
Domain	HX	MMP8 MMP10 MMP12	4.48e-04	23	123	3	SM00120
Domain	M10A_MMP	MMP8 MMP10 MMP12	4.48e-04	23	123	3	IPR033739
Domain	Hemopexin	MMP8 MMP10 MMP12	4.48e-04	23	123	3	PF00045
Domain	Pept_M10A	MMP8 MMP10 MMP12	4.48e-04	23	123	3	IPR021190
Domain	Peptidase_M10	MMP8 MMP10 MMP12	5.10e-04	24	123	3	PF00413
Domain	ITI_HC_C	ITIH2 ITIH3	6.34e-04	6	123	2	IPR010600
Domain	ITI_HC_C	ITIH2 ITIH3	6.34e-04	6	123	2	PF06668
Domain	PLipase_D/transphosphatidylase	PGS1 PLD2	8.84e-04	7	123	2	IPR001736
Domain	PLD	PGS1 PLD2	8.84e-04	7	123	2	PS50035
Domain	Peptidase_Metallo	MMP8 MMP10 MMP12	8.99e-04	29	123	3	IPR006026
Domain	ZnMc	MMP8 MMP10 MMP12	8.99e-04	29	123	3	SM00235
Domain	-	DPP10 CES5A BAAT BCHE FASN	1.15e-03	119	123	5	3.40.50.1820
Domain	AB_hydrolase	DPP10 CES5A BAAT BCHE FASN	1.15e-03	119	123	5	IPR029058
Domain	Carboxylesterase_B_AS	CES5A BCHE	1.17e-03	8	123	2	IPR019826
Domain	VIT	ITIH2 ITIH3	1.17e-03	8	123	2	PF08487
Domain	VIT	ITIH2 ITIH3	1.17e-03	8	123	2	SM00609
Domain	CARBOXYLESTERASE_B_1	CES5A BCHE	1.17e-03	8	123	2	PS00122
Domain	-	GPX3 GPX5 MRPS25 GPX6 PDCL	1.28e-03	122	123	5	3.40.30.10
Domain	GPS	PKD1L1 ADGRV1 ADGRG6	1.70e-03	36	123	3	PS50221
Domain	C2	C2CD3 OTOF PIK3C2G CPNE1 PRKCA	1.75e-03	131	123	5	PF00168
Domain	Thioredoxin-like_fold	GPX3 GPX5 MRPS25 GPX6 PDCL	1.81e-03	132	123	5	IPR012336
Domain	GPS	PKD1L1 ADGRV1 ADGRG6	1.84e-03	37	123	3	IPR000203
Domain	IPPc	OCRL INPP5J	1.87e-03	10	123	2	IPR000300
Domain	VIT	ITIH2 ITIH3	1.87e-03	10	123	2	PS51468
Domain	IPPc	OCRL INPP5J	1.87e-03	10	123	2	SM00128
Domain	VIT	ITIH2 ITIH3	1.87e-03	10	123	2	IPR013694
Domain	C2	C2CD3 OTOF PIK3C2G CPNE1 PRKCA	2.14e-03	137	123	5	SM00239
Domain	CYSTEINE_SWITCH	MMP8 MMP10 MMP12	2.48e-03	41	123	3	PS00546
Domain	C2	C2CD3 OTOF PIK3C2G CPNE1 PRKCA	2.50e-03	142	123	5	PS50004
Domain	Pept_M10_metallopeptidase	MMP8 MMP10 MMP12	2.84e-03	43	123	3	IPR001818
Domain	-	C2CD3 OTOF PIK3C2G CPNE1 PRKCA	2.98e-03	148	123	5	2.60.40.150
Domain	Kinase-like_dom	ERBB2 DAPK2 DAPK1 DAPK3 TEX14 LCK GRK3 PIK3C2G PRKCA MAP2K1	3.13e-03	542	123	10	IPR011009
Domain	Carboxylesterase_B_CS	CES5A BCHE	3.20e-03	13	123	2	IPR019819
Domain	ConA-like_dom	COL11A1 FAT3 ADGRV1 EGFL6 LGALS4 ADGRG6	3.31e-03	219	123	6	IPR013320
Domain	Protein_kinase_ATP_BS	ERBB2 DAPK2 DAPK1 DAPK3 LCK GRK3 PRKCA MAP2K1	3.63e-03	379	123	8	IPR017441
Domain	CARBOXYLESTERASE_B_2	CES5A BCHE	3.72e-03	14	123	2	PS00941
Domain	COesterase	CES5A BCHE	3.72e-03	14	123	2	PF00135
Domain	CarbesteraseB	CES5A BCHE	3.72e-03	14	123	2	IPR002018
Domain	C2_dom	C2CD3 OTOF PIK3C2G CPNE1 PRKCA	4.62e-03	164	123	5	IPR000008
Domain	Prot_kinase_dom	ERBB2 DAPK2 DAPK1 DAPK3 TEX14 LCK GRK3 PRKCA MAP2K1	5.08e-03	489	123	9	IPR000719
Domain	-	SLC25A51 SLC25A40 SLC25A52	5.14e-03	53	123	3	1.50.40.10
Domain	Mito_carr	SLC25A51 SLC25A40 SLC25A52	5.14e-03	53	123	3	PF00153
Domain	SOLCAR	SLC25A51 SLC25A40 SLC25A52	5.14e-03	53	123	3	PS50920
Domain	Mitochondrial_sb/sol_carrier	SLC25A51 SLC25A40 SLC25A52	5.14e-03	53	123	3	IPR018108
Domain	Mt_carrier_dom	SLC25A51 SLC25A40 SLC25A52	5.14e-03	53	123	3	IPR023395
Domain	PROTEIN_KINASE_DOM	ERBB2 DAPK2 DAPK1 DAPK3 TEX14 LCK GRK3 PRKCA MAP2K1	5.35e-03	493	123	9	PS50011
Domain	Cadherin_CS	DSG3 CDHR2 FAT3 CDH19	5.86e-03	109	123	4	IPR020894
Domain	-	GDI1 SQOR PAOX	5.99e-03	56	123	3	3.50.50.60
Domain	FAD/NAD-binding_dom	GDI1 SQOR PAOX	6.30e-03	57	123	3	IPR023753
Pathway	WP_BLADDER_CANCER	ERBB2 DAPK2 DAPK1 DAPK3 TYMP MAP2K1	3.67e-07	40	101	6	M39523
Pathway	KEGG_BLADDER_CANCER	ERBB2 DAPK2 DAPK1 DAPK3 TYMP MAP2K1	4.96e-07	42	101	6	M19096
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PGS1 BCHE OCRL RUFY1 SLC44A1 PIK3C2G CPNE1 PLD2 INPP5J	2.02e-05	211	101	9	M649
Pathway	KEGG_GLUTATHIONE_METABOLISM	RRM2B GPX3 GPX5 GPX6 OPLAH	2.80e-05	50	101	5	M1840
Pathway	REACTOME_CASPASE_ACTIVATION_VIA_DEPENDENCE_RECEPTORS_IN_THE_ABSENCE_OF_LIGAND	DAPK2 DAPK1 DAPK3	4.13e-05	10	101	3	M866
Pathway	KEGG_MEDICUS_REFERENCE_GLUTATHIONE_BIOSYNTHESIS	GPX3 GPX5 GPX6	5.65e-05	11	101	3	M47926
Pathway	REACTOME_METABOLISM_OF_LIPIDS	PGS1 ABCA1 ACADM CYP27A1 BAAT BCHE OCRL RUFY1 ACSL1 GRHL1 FASN SLC44A1 PIK3C2G CPNE1 PLD2 INPP5J	9.00e-05	757	101	16	M27451
Pathway	BIOCARTA_CCR3_PATHWAY	PIK3C2G PRKCA MAP2K1	3.18e-04	19	101	3	MM1361
Pathway	BIOCARTA_CXCR4_PATHWAY	PIK3C2G PRKCA MAP2K1	3.18e-04	19	101	3	MM1375
Pathway	BIOCARTA_CXCR4_PATHWAY	PIK3C2G PRKCA MAP2K1	3.18e-04	19	101	3	M882
Pathway	BIOCARTA_CCR3_PATHWAY	PIK3C2G PRKCA MAP2K1	3.18e-04	19	101	3	M9152
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	PRKCA MMP8 MMP10 MMP12	3.22e-04	46	101	4	M46450
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ABCA1 CYP27A1 ACSL1 FASN	3.49e-04	47	101	4	M39853
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	OCRL RUFY1 PIK3C2G INPP5J	4.44e-04	50	101	4	MM14641
Pathway	KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	LCK PRKCA KIR2DL2 KIR2DL3 KIR2DS3 MAP2K1	4.49e-04	137	101	6	M5669
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	OCRL RUFY1 SLC44A1 PIK3C2G CPNE1 PLD2 INPP5J	5.15e-04	196	101	7	MM14591
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ABCA1 CYP27A1 ACSL1 FASN	5.16e-04	52	101	4	MM15920
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	OCRL RUFY1 PIK3C2G INPP5J	5.55e-04	53	101	4	M662
Pathway	REACTOME_COLLAGEN_DEGRADATION	COL11A1 MMP8 MMP10 MMP12	5.55e-04	53	101	4	MM14566
Pathway	WP_ONECARBON_METABOLISM_AND_RELATED_PATHWAYS	BAAT GPX3 GPX5 GPX6	5.96e-04	54	101	4	MM15848
Pubmed	Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.53e-09	6	127	4	17882223
Pubmed	NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.17e-08	8	127	4	18681957
Pubmed	Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.11e-08	9	127	4	7749980
Pubmed	Alternatively spliced forms of human killer inhibitory receptors.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.11e-08	9	127	4	8662091
Pubmed	Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.50e-08	10	127	4	12559621
Pubmed	The death-associated protein kinases: structure, function, and beyond.	DAPK2 DAPK1 DAPK3	4.76e-08	3	127	3	16756490
Pubmed	Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.	KIR2DS2 KIR2DL2 KIR2DL3	4.76e-08	3	127	3	30696053
Pubmed	Associations of killer cell immunoglobulin- like receptor genes with rheumatoid arthritis.	KIR2DS2 KIR2DL2 KIR2DL3	4.76e-08	3	127	3	22960345
Pubmed	Imputation of KIR Types from SNP Variation Data.	KIR2DS2 KIR2DL2 KIR2DL3	4.76e-08	3	127	3	26430804
Pubmed	Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes.	KIR2DS2 KIR2DL2 KIR2DL3	4.76e-08	3	127	3	18292496
Pubmed	Natural killer cells and immune surveillance.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	5.49e-08	11	127	4	18830515
Pubmed	[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	5.49e-08	11	127	4	19664392
Pubmed	Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	8.20e-08	12	127	4	20371502
Pubmed	Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	8.20e-08	12	127	4	19936734
Pubmed	Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	8.20e-08	12	127	4	19181658
Pubmed	KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.18e-07	13	127	4	19934297
Pubmed	Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.18e-07	13	127	4	19120281
Pubmed	[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.18e-07	13	127	4	18687225
Pubmed	Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.65e-07	14	127	4	19875891
Pubmed	[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.65e-07	14	127	4	19489269
Pubmed	Multiple sclerosis associates with LILRA3 deletion in Spanish patients.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.65e-07	14	127	4	19421224
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.65e-07	14	127	4	15896204
Pubmed	KIR/HLA ligand incompatibility in kidney transplantation.	KIR2DS2 KIR2DL2 KIR2DL3	1.90e-07	4	127	3	18091530
Pubmed	Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility.	KIR2DS2 KIR2DL2 KIR2DL3	1.90e-07	4	127	3	16929347
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	20082646
Pubmed	Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	19850842
Pubmed	[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	20356536
Pubmed	Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	19926642
Pubmed	Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	20207982
Pubmed	Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	19493232
Pubmed	Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	20643584
Pubmed	KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	17498266
Pubmed	Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.24e-07	15	127	4	19326408
Pubmed	Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	19897003
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	19000141
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	20670355
Pubmed	Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	18668235
Pubmed	Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	19309280
Pubmed	[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	16403292
Pubmed	Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	19527230
Pubmed	Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	20652381
Pubmed	Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	19279038
Pubmed	No association of KIR genes with Behcet's disease.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	17868255
Pubmed	A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	18643961
Pubmed	Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	20331834
Pubmed	HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	2.98e-07	16	127	4	20210919
Pubmed	[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	19968064
Pubmed	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	20878400
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	20650299
Pubmed	The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	20173784
Pubmed	The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	20173792
Pubmed	Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	20483367
Pubmed	[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	19218127
Pubmed	KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	19169284
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	19450876
Pubmed	Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.89e-07	17	127	4	19761533
Pubmed	Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus.	KIR2DS2 KIR2DL2 KIR2DL3	4.73e-07	5	127	3	18755860
Pubmed	Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.	KIR2DS2 KIR2DL2 KIR2DL3	4.73e-07	5	127	3	16112031
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ATP13A1 BCHE APOB F8 ITIH2 ITIH3 ADGRG6 PLXDC2 TNXB	4.74e-07	257	127	9	16335952
Pubmed	Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	4.99e-07	18	127	4	19630074
Pubmed	Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	4.99e-07	18	127	4	20200544
Pubmed	Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	4.99e-07	18	127	4	19046302
Pubmed	Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	4.99e-07	18	127	4	20580654
Pubmed	Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	4.99e-07	18	127	4	20519398
Pubmed	Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	4.99e-07	18	127	4	19846535
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	4.99e-07	18	127	4	20210918
Pubmed	KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	6.30e-07	19	127	4	18571006
Pubmed	Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	6.30e-07	19	127	4	18778326
Pubmed	Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	6.30e-07	19	127	4	20600442
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	6.30e-07	19	127	4	18848853
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	7.85e-07	20	127	4	20193031
Pubmed	Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	9.67e-07	21	127	4	19861144
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.18e-06	22	127	4	20492596
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP8 MMP10 MMP12	1.65e-06	7	127	3	8921407
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP8 MMP10 MMP12	1.65e-06	7	127	3	11113146
Pubmed	HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells.	GPX3 GPX5 GPX6	1.65e-06	7	127	3	15910762
Pubmed	Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation.	GPX3 GPX5 GPX6	1.65e-06	7	127	3	11368344
Pubmed	Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.	KIR2DS2 KIR2DL2 KIR2DL3	1.65e-06	7	127	3	11169255
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DYNC2H1 NUP42 RAD54L2 NUDCD2 WASHC2A RUFY1 ARFGEF3 ZNF516 SENP6 DOT1L SIPA1L2 NONO	1.80e-06	588	127	12	38580884
Pubmed	KIR haplotype content at the allele level in 77 Northern Irish families.	KIR2DS2 KIR2DL2 KIR2DL3	2.63e-06	8	127	3	17200871
Pubmed	Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice.	GPX3 GPX5 GPX6	2.63e-06	8	127	3	10652368
Pubmed	Immunogenetic characteristics of patients with autoimmune gastritis.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	3.75e-06	29	127	4	20082482
Pubmed	Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor.	GPX3 GPX5 GPX6	3.93e-06	9	127	3	9501919
Pubmed	Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	8.13e-06	35	127	4	19683555
Pubmed	[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.].	KIR2DS2 KIR2DL3 KIR2DS3	1.02e-05	12	127	3	20137308
Pubmed	Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.	KIR2DL2 KIR2DL3	1.32e-05	2	127	2	25359276
Pubmed	Allelic polymorphism of KIR2DL2/2DL3 in a southern Chinese population.	KIR2DL2 KIR2DL3	1.32e-05	2	127	2	26423800
Pubmed	KIR2DL2/S2 and HLA-C C1C1 genotype is associated with better response to treatment and prolonged survival of patients with non-small cell lung cancer in a Polish Caucasian population.	KIR2DS2 KIR2DL2	1.32e-05	2	127	2	22836042
Pubmed	Ser289 phosphorylation activates both DAPK1 and DAPK2 but in response to different intracellular signaling pathways.	DAPK2 DAPK1	1.32e-05	2	127	2	31116076
Pubmed	Characterization, regulation of the expression and putative roles of two glutathione peroxidase proteins found in the mouse epididymis.	GPX3 GPX5	1.32e-05	2	127	2	10645275
Pubmed	Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.	KIR2DL2 KIR2DL3	1.32e-05	2	127	2	33846289
Pubmed	Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses.	OTOF SLC17A8	1.32e-05	2	127	2	37745283
Pubmed	Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells.	DAPK2 DAPK1	1.32e-05	2	127	2	22160140
Pubmed	Expression of KIR2DL3 and KIR2DS2 natural killer receptors in exercise.	KIR2DS2 KIR2DL3	1.32e-05	2	127	2	21165439
Pubmed	Identification of four novel KIR2DL2 alleles and two novel KIR2DL3 alleles in an East African population.	KIR2DL2 KIR2DL3	1.32e-05	2	127	2	20875478
Pubmed	Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway.	ABCA1 PLD2	1.32e-05	2	127	2	16118212
Pubmed	Clinical and histopathological changes in different KIR gene profiles in chronic HCV Romanian patients.	KIR2DS2 KIR2DL2	1.32e-05	2	127	2	32961633
Pubmed	Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs.	ERBB2 FASN	1.32e-05	2	127	2	26107737
Pubmed	Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2.	DAPK2 DAPK1	1.32e-05	2	127	2	18535204
Pubmed	Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.	ABCA1 APOB	1.32e-05	2	127	2	28694219
Interaction	MMP16 interactions	ERBB2 MMP8 MMP10 MMP12	3.91e-06	18	124	4	int:MMP16
Cytoband	19q13.4	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	7.15e-05	79	127	4	19q13.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	DYNC2H1 MMP8 MMP10 MMP12	2.31e-04	107	127	4	chr11q22
Cytoband	11q22.3	MMP8 MMP10 MMP12	2.52e-04	44	127	3	11q22.3
Cytoband	18q12.1	DSG3 SLC25A52	2.36e-03	26	127	2	18q12.1
Cytoband	16q12.2	CES5A RBL2	2.36e-03	26	127	2	16q12.2
Cytoband	18q23	SALL3 ZNF516	2.94e-03	29	127	2	18q23
GeneFamily	Ankyrin repeat domain containing\|Death associated protein kinases	DAPK2 DAPK1 DAPK3	1.11e-06	5	88	3	1021
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3	1.52e-06	18	88	4	620
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP8 MMP10 MMP12	2.09e-04	24	88	3	891
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	ERBB2 TYMP CTSH	1.96e-03	51	88	3	870
GeneFamily	Cadherin related	CDHR2 FAT3	3.04e-03	17	88	2	24
Coexpression	CAIRO_LIVER_DEVELOPMENT_DN	ACADM CYP27A1 APOB SQOR ITIH2 ITIH3 ACSL1 CTSH	1.37e-05	225	126	8	M6175
Coexpression	AIZARANI_LIVER_C11_HEPATOCYTES_1	ABCA1 ACADM CYP27A1 BAAT BCHE APOB ITIH2 ITIH3 ACSL1	1.45e-05	298	126	9	M39115
Coexpression	CAIRO_LIVER_DEVELOPMENT_DN	ACADM CYP27A1 APOB SQOR ITIH2 ITIH3 ACSL1 CTSH	2.12e-05	239	126	8	MM1274
Coexpression	DESCARTES_FETAL_PLACENTA_AFP_ALB_POSITIVE_CELLS	BAAT BCHE APOB SIRT4 ITIH2 ITIH3 PIK3C2G	2.19e-05	174	126	7	M40276
Coexpression	GSE25085_FETAL_LIVER_VS_FETAL_BM_SP4_THYMIC_IMPLANT_DN	DMXL2 DYNC2H1 PHYHD1 GDI1 PLXDC2 MMP8 MMP12	5.32e-05	200	126	7	M8076
Coexpression	GSE17721_CTRL_VS_PAM3CSK4_6H_BMDC_DN	RANBP2 SCAF8 WASHC2A SQOR SLC44A1 G3BP1 MMP12	5.32e-05	200	126	7	M3742
Coexpression	GSE15930_STIM_VS_STIM_AND_IL12_48H_CD8_T_CELL_DN	PGS1 ABCA1 SQOR ACSL1 ABCB10 G3BP1 MMP10	5.32e-05	200	126	7	M3631
Coexpression	GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_UP	DAPK1 SQOR ADGRG6 ZNF516 DOT1L MMP8 MMP12	5.32e-05	200	126	7	M6655
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA COL11A1 FAT3 APOB ADGRV1 ARFGEF3 PIK3C2G HYDIN MYO16	2.67e-09	184	125	9	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA COL11A1 FAT3 APOB ADGRV1 ARFGEF3 PIK3C2G HYDIN MYO16	2.67e-09	184	125	9	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA COL11A1 FAT3 APOB ADGRV1 ARFGEF3 PIK3C2G HYDIN MYO16	2.67e-09	184	125	9	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1C COL11A1 DPP10 CDHR2 FAT3 BAAT ADGRV1 HYDIN	1.95e-08	162	125	8	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	droplet-Heart-nan-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 GPX3 DAPK1 ITIH2 FASN MMP8 CTSH TNXB	3.41e-08	174	125	8	cf4e0567f2a4ebe5534046b1c091af59b55bdc4f
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	DMXL2 ABCA1 CYP27A1 TYMP ACSL1 GRK3 PLXDC2 SIPA1L2	8.22e-08	195	125	8	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	COVID-19-Myeloid\|COVID-19 / group, cell type (main and fine annotations)	DMXL2 ABCA1 CYP27A1 DAPK1 TYMP ACSL1 GRK3 PLXDC2	9.25e-08	198	125	8	33f0a919188a67d2a876b52c61a1cec2c9747969
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	OTOA DMXL2 ABCA1 CYP27A1 DAPK1 TYMP ACSL1 PLXDC2	9.99e-08	200	125	8	2d2835f97e0ff4f99d384f18e10876575f6bdefd
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac-Macrophage\|GI_small-bowel / Manually curated celltypes from each tissue	OTOA DMXL2 CYP27A1 DAPK1 MMP10 MMP12 CTSH	4.92e-07	168	125	7	d5b746d6083c2c8155a0ea345ea368bf6617d5ca
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	DMXL2 ABCA1 DAPK1 TYMP ADGRG6 MMP10 MMP12	7.82e-07	180	125	7	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C FAT3 GPX3 BCHE GRK3 TNXB MYO16	7.82e-07	180	125	7	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control\|World / Disease state, Lineage and Cell class	RANBP2 DMXL2 ABCA1 SFTPD ACSL1 SLC44A1 MAP2K1	1.08e-06	189	125	7	fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 CYP27A1 DAPK1 TYMP ACSL1 GRK3 PLXDC2	1.20e-06	192	125	7	bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 TYMP WASHC2A SQOR ACSL1 GRK3 PLXDC2	1.20e-06	192	125	7	b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL11A1 SFTPD ADGRV1 ARFGEF3 FASN PRKCA CTSH	1.20e-06	192	125	7	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 SFTPD DYNC2H1 SPEF2 ARFGEF3 CTSH HYDIN	1.25e-06	193	125	7	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 TYMP SQOR ACSL1 GRK3 PLXDC2 OTOF	1.25e-06	193	125	7	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DAPK2 BAAT DAPK1 ITIH2 ARFGEF3 GRHL1 MRPS25	1.29e-06	194	125	7	5b29c843186c2394f5bec3b1d5ae284a0d931d85
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DAPK2 BAAT DAPK1 ITIH2 ARFGEF3 GRHL1 MRPS25	1.29e-06	194	125	7	ebcf6c6d0eb20a5d422becf5a730089230c8ba9a
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 TYMP SQOR ACSL1 GRK3 PLXDC2 OTOF	1.29e-06	194	125	7	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DAPK2 BAAT DAPK1 ITIH2 ARFGEF3 GRHL1 MRPS25	1.29e-06	194	125	7	8c6e5ba27a988e0cd6b8c25cb9a30a0da2b1f7f9
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DAPK2 BAAT DAPK1 ITIH2 ARFGEF3 GRHL1 MRPS25	1.29e-06	194	125	7	6e78e3046c5b172af92a84e25f982377a0aaac58
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	DMXL2 ABCA1 DAPK1 TYMP ACSL1 GRK3 PLXDC2	1.34e-06	195	125	7	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DMXL2 ABCA1 CYP27A1 TYMP ACSL1 PLXDC2 SIPA1L2	1.34e-06	195	125	7	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DPP10 DAPK2 DAPK1 ADGRV1 ARFGEF3 GRHL1 MRPS25	1.34e-06	195	125	7	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	DMXL2 PGS1 ABCA1 ACSL1 ERGIC1 GRK3 MAP2K1	1.34e-06	195	125	7	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OTOA DMXL2 ABCA1 DAPK1 TYMP MMP12 CTSH	1.34e-06	195	125	7	5a7c74f96f213c504abd65e751800da7e03e47d9
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ERBB2 SFTPD DAPK2 DAPK1 ARFGEF3 GRHL1 MRPS25	1.38e-06	196	125	7	d5f9168001e60bafec17fe6c702e68f5528edc20
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OTOA DMXL2 ABCA1 DAPK1 TYMP MMP12 CTSH	1.43e-06	197	125	7	e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OTOA CACNA1C FAT3 ITIH2 TNXB MYO16	1.46e-06	125	125	6	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	OTOA DMXL2 CYP27A1 GPX3 DAPK1 PLXDC2 MMP12	1.48e-06	198	125	7	c08018f099a381a66993cb60288954a6e47f105f
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	OTOA DMXL2 CYP27A1 GPX3 DAPK1 PLXDC2 MMP12	1.48e-06	198	125	7	27cc7f786fb8cb230589d762a4e51b46265c1f19
ToppCell	CF-Myeloid-Monocyte_Macrophage\|CF / Disease state, Lineage and Cell class	CYP27A1 DAPK1 SLC44A1 GRK3 G3BP1 MMP12 CTSH	1.53e-06	199	125	7	bf95eacb31a4a847350f9d6e95ca76c6b730c400
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	OTOA DMXL2 CYP27A1 GPX3 DAPK1 ACSL1 PLXDC2	1.53e-06	199	125	7	80ed217d28ba1c07facd0e103c25a02658dd848d
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	OTOA DMXL2 ABCA1 CYP27A1 DAPK1 TYMP PLXDC2	1.58e-06	200	125	7	ea039de8bd8b325845ce361f84e600c6dad922ed
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_other\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	OTOA DMXL2 ABCA1 CYP27A1 TYMP ACSL1 PLXDC2	1.58e-06	200	125	7	eac46978e2b3d38cf42b44f7b0350d0489d036b3
ToppCell	Mild-Myeloid-Macrophages-FCN1-SPP1+\|Mild / Condition, Lineage, Cell class and cell subclass	OTOA DMXL2 ABCA1 CYP27A1 ACSL1 PLXDC2 CTSH	1.58e-06	200	125	7	e5afd8e2cb2c63899d49fe17011f474d20bb06ea
ToppCell	Macroglial-Astrocytes-GFAP---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CFAP47 DPP10 FAT3 DAPK1 PHYHD1 ADGRV1 CTSH	1.58e-06	200	125	7	88d66550781a3c9102ff7455f5cff6fb072943cd
ToppCell	Macroglial-Astrocytes-GFAP-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CFAP47 DPP10 FAT3 DAPK1 PHYHD1 ADGRV1 CTSH	1.58e-06	200	125	7	d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCell	Macroglial-Astrocytes-GFAP--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CFAP47 DPP10 FAT3 DAPK1 PHYHD1 ADGRV1 CTSH	1.58e-06	200	125	7	16269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCell	Macroglial-Astrocytes-GFAP----L1-2\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CFAP47 DPP10 FAT3 DAPK1 PHYHD1 ADGRV1 CTSH	1.58e-06	200	125	7	c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCell	Macroglial-Astrocytes-GFAP\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CFAP47 DPP10 FAT3 DAPK1 PHYHD1 ADGRV1 CTSH	1.58e-06	200	125	7	79634b1086934412ae92f259ab43554ce545008f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYP27A1 CDH19 ACSL1 CD1C FASN CTSH	4.04e-06	149	125	6	c773c2b9685ec44a35246180a93456c8765353f5
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CFAP47 OTOA SFTPD EGFL6 ARFGEF3 FASN	5.08e-06	155	125	6	be575a0096415705dba425002247289ff8f89474
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT2_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PGS1 TEX14 EGFL6 ARFGEF3 PIK3C2G CTSH	5.08e-06	155	125	6	9cad73d0b8ead289e1073d1a2e00bbeb1228308c
ToppCell	FLU-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	DAPK2 PHYHD1 F8 PAOX CPNE1 KIR2DL2	5.88e-06	159	125	6	97c8e16a7ac10ebba96daee97f9fb1d4a404f23b
ToppCell	FLU-Healthy-1\|FLU / Virus stimulation, Condition and Cluster	DAPK2 PHYHD1 F8 PAOX CPNE1 KIR2DL2	5.88e-06	159	125	6	fe2a9f79b058e89214256e736f6e266830cdfa28
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL11A1 FAT3 ADGRV1 PIK3C2G GPX6 HYDIN	6.09e-06	160	125	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL11A1 FAT3 ADGRV1 PIK3C2G GPX6 HYDIN	6.09e-06	160	125	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFTPD DAPK1 EGFL6 FASN CTSH MYO16	6.54e-06	162	125	6	06f5d6c0bb26fe9d5180bc2ebf2c54bf52e715f3
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFTPD DAPK1 EGFL6 FASN CTSH MYO16	6.54e-06	162	125	6	d0d9c18a73bc0bf4f38308ef2eee8ae20f6a7918
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 DPP10 GRK3 PLD2 VPS51 CTSH	8.05e-06	168	125	6	d72cd8238fa793bb3e4add4c59eaaaadcea9930d
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 DPP10 GRK3 PLD2 VPS51 CTSH	8.05e-06	168	125	6	c34c52165485f612add7a3e35a175d5a6e365e7c
ToppCell	facs-Thymus-nan-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 DPP10 GRK3 PLD2 VPS51 CTSH	8.05e-06	168	125	6	d2afc097ae1243574210be6a751685f949ea941a
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C VPS13C F8 GRK3 PRKCA DAAM1	9.84e-06	174	125	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BAAT GPX5 APOB ITIH2 ITIH3 PIK3C2G	1.05e-05	176	125	6	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP10 TDRD9 GPX3 OCRL OTOF PIK3C2G	1.08e-05	177	125	6	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP10 TDRD9 GPX3 OCRL OTOF PIK3C2G	1.08e-05	177	125	6	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DAPK2 DAPK1 ADGRV1 ARFGEF3 GRHL1 MRPS25	1.12e-05	178	125	6	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFTPD APOB EGFL6 FASN CTSH DEK	1.16e-05	179	125	6	bf012825e88626e59cd1deebf67c2cd269ce4829
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OTOA ABCA1 ACO1 CYP27A1 TEX14 TYMP	1.16e-05	179	125	6	b07ebfd4157ae7436f275add78f2ac9ffc55f417
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DPP10 ADGRV1 TEX14 ARFGEF3 GRHL1 MRPS25	1.19e-05	180	125	6	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C FAT3 GPX3 BCHE TNXB MYO16	1.19e-05	180	125	6	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OTOA DMXL2 ABCA1 DAPK1 GRK3 MMP12	1.27e-05	182	125	6	ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	DPP10 ACO1 TMEM135 ACSL1 FASN GRK3	1.31e-05	183	125	6	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	DPP10 ACO1 TMEM135 ACSL1 FASN GRK3	1.31e-05	183	125	6	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 TYMP SQOR ACSL1 PLXDC2 CTSH	1.31e-05	183	125	6	4763df29c888d47c22076803b054f06b4cc29368
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 TYMP SQOR ACSL1 PLXDC2 CTSH	1.31e-05	183	125	6	fcb0f755382d88fb207fc2322cd224c09c6e2ea6
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DAPK2 DAPK1 ADGRV1 ARFGEF3 GRHL1 MRPS25	1.39e-05	185	125	6	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	10x5'-GI_small-bowel-Myeloid_Dendritic-DC2\|GI_small-bowel / Manually curated celltypes from each tissue	SFTPD DAPK1 TYMP CD1C GRK3 CTSH	1.39e-05	185	125	6	f78be85dd6e443abb7af20f98ff351c1131ece4d
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC2\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SFTPD TYMP CD1C GRK3 MMP12 CTSH	1.44e-05	186	125	6	69b107ad88b07e9aeef09d4e4dac99b0cb6b467e
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	DAPK2 DAPK1 ADGRV1 ARFGEF3 GRHL1 MRPS25	1.48e-05	187	125	6	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	APOB ACSL1 CD1C PLXDC2 UBE2F PLD2	1.48e-05	187	125	6	5917bdfe84cf5941e21b415aebbab3090cc5d576
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFTPD DAPK1 EGFL6 ARFGEF3 FASN CTSH	1.53e-05	188	125	6	7499e353ea5853d06558b20cedee3c7910425d7d
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFTPD DAPK1 EGFL6 ARFGEF3 FASN CTSH	1.53e-05	188	125	6	562f5984efdbbcb8f53ddcee033ccbf9eb678425
ToppCell	facs-Skin-Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP27A1 GPX3 HNRNPF SLC44A1 CPNE1 NONO	1.57e-05	189	125	6	adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	DMXL2 PGS1 SFTPD TYMP ACSL1 FASN	1.57e-05	189	125	6	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	DYNC2H1 CYP27A1 GPX3 CDH19 PLXDC2 TNXB	1.62e-05	190	125	6	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	FAT3 DAPK1 ADGRG6 SLC44A1 GRK3 PLXDC2	1.62e-05	190	125	6	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C FAT3 GPX3 GRK3 PLXDC2 MYO16	1.67e-05	191	125	6	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PGS1 SFTPD DAPK1 EGFL6 FASN CTSH	1.67e-05	191	125	6	08b1d3b3be78bf7fd9e9039027e35275f2be88d0
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PGS1 SFTPD DAPK1 EGFL6 FASN CTSH	1.67e-05	191	125	6	f896fb490c4a17adac5e00ed9b6e6145eab1e564
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C FAT3 ADGRG6 GRK3 TNXB MYO16	1.67e-05	191	125	6	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DPP10 DAPK1 ADGRV1 ARFGEF3 GRHL1 MRPS25	1.67e-05	191	125	6	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 TYMP SQOR ACSL1 GRK3 PLXDC2	1.67e-05	191	125	6	c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	DMXL2 CYP27A1 DAPK1 ACSL1 GRK3 PLXDC2	1.67e-05	191	125	6	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	DMXL2 ABCA1 CYP27A1 GRK3 PLXDC2 SIPA1L2	1.72e-05	192	125	6	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 DAPK1 TYMP ACSL1 PLXDC2 CTSH	1.77e-05	193	125	6	45205ad1ef12aabf33059a7ff922a3bb86994c2f
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	DMXL2 CYP27A1 TYMP GRK3 PLXDC2 SIPA1L2	1.77e-05	193	125	6	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 DAPK1 TYMP ACSL1 PLXDC2 CTSH	1.77e-05	193	125	6	1beca3d3b34082b7d9112fbd094bee8019921ca0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 DAPK1 TYMP ACSL1 PLXDC2 CTSH	1.77e-05	193	125	6	2ebb950476767f330241b0077ced22e55e124359
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 TYMP ACSL1 PLXDC2 SIPA1L2 CTSH	1.77e-05	193	125	6	d845beb0915a5b4bbd1e8f9b8d9322527a822849
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 CYP27A1 TYMP ACSL1 PLXDC2 CTSH	1.77e-05	193	125	6	69352551ad5db325ac0d6df2ac1e35ae473ac01f
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ERBB2 BAAT DAPK1 ARFGEF3 GRHL1 MRPS25	1.77e-05	193	125	6	525e0de0f25f3308daf49e7d4c8774562f1f40ad
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ERBB2 BAAT DAPK1 ARFGEF3 GRHL1 MRPS25	1.77e-05	193	125	6	2d18f39615043dfbff120a00f6540ffa93082c83
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DMXL2 CYP27A1 ACSL1 GRK3 PLXDC2 SIPA1L2	1.82e-05	194	125	6	69cf7c989ac355c459db13f9d4267b55adc3c174
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	DMXL2 ABCA1 WASHC2A ACSL1 PLXDC2 MAP2K1	1.82e-05	194	125	6	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC-DC2\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PHYHD1 TYMP CD1C NANS CTSH INPP5J	1.82e-05	194	125	6	833c695779edc94690b08814b0dedcf00ae082cd
ToppCell	Control-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	DMXL2 ABCA1 ACSL1 SLC44A1 PLXDC2 MAP2K1	1.82e-05	194	125	6	c35bf04d5e7450cb6679a036fcabb1b28f409f29
ToppCell	CTRL-Myeloid-Alveolar_Macrophage\|CTRL / Disease state, Lineage and Cell class	DMXL2 ACO1 CYP27A1 DAPK1 GRK3 PLXDC2	1.82e-05	194	125	6	be69b20afa915978c4cf2feb0bb21ab7c1f301a5
Disease	Visceral myopathy familial external ophthalmoplegia	RRM2B TYMP	1.64e-05	2	120	2	C1848586
Disease	high grade glioma (is_implicated_in)	ERBB2 SLC44A1 PRKCA MAP2K1	2.58e-05	42	120	4	DOID:3070 (is_implicated_in)
Disease	Hereditary hearing loss and deafness	OTOA COL11A1 RRM2B TWNK OTOF SLC17A8	3.04e-05	146	120	6	cv:C0236038
Disease	MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME	RRM2B TYMP	4.91e-05	3	120	2	C0872218
Disease	2'-O-methylcytidine measurement	DOLK PHYHD1	1.63e-04	5	120	2	EFO_0800635
Disease	Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 1	RRM2B TWNK	1.63e-04	5	120	2	C1834846
Disease	cytochrome c oxidase subunit 6C measurement	PLXDC2 PRKCA	2.43e-04	6	120	2	EFO_0801515
Disease	stromelysin-2 measurement	MMP8 MMP10	2.43e-04	6	120	2	EFO_0802095
Disease	small integral membrane protein 9 measurement	BCHE SQOR	2.43e-04	6	120	2	EFO_0802075
Disease	matrix metalloproteinase 10 measurement	MMP8 MMP10	3.40e-04	7	120	2	EFO_0010589
Disease	coiled-coil domain-containing protein 126 measurement	ABCA1 BCHE	3.40e-04	7	120	2	EFO_0801482
Disease	NAD-dependent protein deacetylase sirtuin-2 measurement	ITIH2 PRKCA	3.40e-04	7	120	2	EFO_0008241
Disease	retinal detachment	FAT3 CDH19	3.40e-04	7	120	2	EFO_0005773
Disease	Malignant neoplasm of breast	ERBB2 COL11A1 ACADM DYNC2H1 BCHE RUFY1 SLC25A51 FASN ABCB10 OTOF PLD2 MMP10 DEK	4.39e-04	1074	120	13	C0006142
Disease	common bile duct neoplasm (is_marker_for)	APOB TYMP	4.52e-04	8	120	2	DOID:4608 (is_marker_for)
Disease	ductal carcinoma in situ (is_marker_for)	ERBB2 TYMP PRKCA	5.39e-04	39	120	3	DOID:0060074 (is_marker_for)
Disease	Mitochondrial DNA Deletion Syndromes	RRM2B TWNK	5.80e-04	9	120	2	cv:CN043632
Disease	Squamous cell carcinoma of esophagus	FAT3 TYMP FASN TNXB	6.23e-04	95	120	4	C0279626
Disease	Adenocarcinoma of large intestine	ERBB2 DAPK3 PRKCA MAP2K1	6.48e-04	96	120	4	C1319315
Disease	type 2 diabetes mellitus (is_implicated_in)	ABCA1 GPX3 BCHE APOB PIK3C2G	6.87e-04	171	120	5	DOID:9352 (is_implicated_in)
Disease	hearing impairment	OTOA ADGRV1 OTOF SLC17A8	7.00e-04	98	120	4	C1384666
Disease	adseverin measurement	BCHE CPNE1	7.23e-04	10	120	2	EFO_0801358
Disease	coronary artery disease (is_implicated_in)	ABCA1 BCHE APOB MMP12	7.55e-04	100	120	4	DOID:3393 (is_implicated_in)
Disease	cytochrome p450 3a4 measurement	BCHE APOB	8.81e-04	11	120	2	EFO_0020303
Disease	cell growth regulator with EF hand domain protein 1 measurement	PLXDC2 CPNE1	8.81e-04	11	120	2	EFO_0801461
Disease	Barrett's esophagus (is_implicated_in)	GPX3 MMP12	8.81e-04	11	120	2	DOID:9206 (is_implicated_in)
Disease	hyperhomocysteinemia (implicated_via_orthology)	BCHE F8	8.81e-04	11	120	2	DOID:9279 (implicated_via_orthology)
Disease	congestive heart failure (biomarker_via_orthology)	ERBB2 PRKCA PLD2 MMP8	9.72e-04	107	120	4	DOID:6000 (biomarker_via_orthology)
Disease	integral membrane protein 2B measurement	BCHE APOB	1.05e-03	12	120	2	EFO_0802634
Disease	gallbladder carcinoma (is_marker_for)	GPX3 TYMP	1.05e-03	12	120	2	DOID:4948 (is_marker_for)
Disease	matrix metalloproteinase measurement	DYNC2H1 MMP12	1.24e-03	13	120	2	EFO_0004744
Disease	T-cell surface glycoprotein CD3 epsilon chain measurement	BCHE PLXDC2	1.24e-03	13	120	2	EFO_0802114
Disease	Hyperlipoproteinemia Type IIb	ABCA1 APOB	1.24e-03	13	120	2	C1704417
Disease	Huntington's disease (is_marker_for)	BCHE GPX6 CTSH	1.32e-03	53	120	3	DOID:12858 (is_marker_for)
Disease	thoracic aortic aneurysm (is_marker_for)	MMP8 MMP12	1.45e-03	14	120	2	DOID:14004 (is_marker_for)
Disease	colonic neoplasm, overall survival	DPP10 DSG3	1.45e-03	14	120	2	EFO_0000638, EFO_0004288
Disease	Saldino-Noonan Syndrome	DYNC2H1 C2CD3	1.45e-03	14	120	2	C0036069
Disease	Obesity	ACADM GPX3 BCHE ACSL1 FASN	1.54e-03	205	120	5	C0028754
Disease	ovarian cancer (is_implicated_in)	ERBB2 APOB PRKCA	1.55e-03	56	120	3	DOID:2394 (is_implicated_in)
Disease	response to olanzapine	CACNA1C ADGRV1	1.66e-03	15	120	2	GO_0097333
Disease	Hypertriglyceridemia	BCHE APOB	1.66e-03	15	120	2	C0020557
Disease	low density lipoprotein particle size measurement	PGS1 ABCA1 APOB	1.72e-03	58	120	3	EFO_0008593
Disease	Malignant Neoplasms	ERBB2 GPX3 FASN MAP2K1	1.88e-03	128	120	4	C0006826
Disease	renal cell carcinoma (is_marker_for)	ERBB2 TYMP PLD2 MAP2K1	1.88e-03	128	120	4	DOID:4450 (is_marker_for)
Disease	Hyperlipoproteinemia Type IIa	ABCA1 APOB	1.90e-03	16	120	2	C0745103
Disease	neutrophil collagenase measurement	CPNE1 MMP8	1.90e-03	16	120	2	EFO_0008248
Disease	Neoplasm Metastasis	ERBB2 DAPK1 TYMP MMP10 DEK	1.97e-03	217	120	5	C0027627
Disease	extrahepatic cholestasis (biomarker_via_orthology)	ABCA1 CYP27A1	2.14e-03	17	120	2	DOID:13619 (biomarker_via_orthology)
Disease	periodontitis	ABCA1 EPPK1 FAT3 ERGIC1 OTOF	2.22e-03	223	120	5	EFO_0000649
Disease	ovarian neoplasm	ERBB2 RBL2 FASN MAP2K1	2.22e-03	134	120	4	C0919267
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	PGS1 ABCA1 APOB SQOR ITIH3	2.27e-03	224	120	5	EFO_0004530, EFO_0008317
Disease	carcinoma (implicated_via_orthology)	ERBB2 SALL3 LCK	2.28e-03	64	120	3	DOID:305 (implicated_via_orthology)
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACADM SIRT4 FASN	2.38e-03	65	120	3	DOID:0080208 (biomarker_via_orthology)
Disease	severe acute respiratory syndrome, COVID-19	PGS1 SFTPD SPEF2 PLXDC2 PIK3C2G PRKCA SIPA1L2	2.40e-03	447	120	7	EFO_0000694, MONDO_0100096
Disease	matrix metalloproteinase 12 measurement	DYNC2H1 MMP12	2.40e-03	18	120	2	EFO_0010590
Disease	Hypercholesterolemia, Familial	ABCA1 APOB	2.40e-03	18	120	2	C0020445
Disease	Malignant neoplasm of ovary	ERBB2 RBL2 FASN MAP2K1	2.41e-03	137	120	4	C1140680
Disease	sodium-coupled monocarboxylate transporter 1 measurement	BCHE APOB	2.68e-03	19	120	2	EFO_0802076
Disease	sphingomyelin 16:0 measurement	ABCA1 SPEF2	2.97e-03	20	120	2	EFO_0010391
Disease	tissue plasminogen activator measurement, coronary artery disease	DYNC2H1 APOB GPX6	3.07e-03	71	120	3	EFO_0001645, EFO_0004791
Disease	esophagus adenocarcinoma (is_implicated_in)	GPX3 MMP12	3.27e-03	21	120	2	DOID:4914 (is_implicated_in)
Disease	nucleotide measurement	DOLK PHYHD1 SIPA1L2	3.32e-03	73	120	3	EFO_0010513
Disease	urinary metabolite measurement	ACADM PHYHD1 CDH19 PAOX MYO16	3.33e-03	245	120	5	EFO_0005116
Disease	Nonsyndromic genetic hearing loss	OTOA OTOF SLC17A8	3.72e-03	76	120	3	cv:C5680182
Disease	Alzheimer disease	ABCA1 PIK3C2G SIPA1L2 MMP12 CTSH TNXB MYO16	3.75e-03	485	120	7	MONDO_0004975
Disease	Non-Small Cell Lung Carcinoma	ERBB2 TMEM135 DAPK1 MAP2K1	3.84e-03	156	120	4	C0007131

Protein segments in the cluster

Peptide	Gene	Start	Entry
KFVEFFGPGVAQLSI	ACO1	276	P21399
VKDVFAFGGAVENPE	ERBB2	1181	P04626
GNEFKNIFGTPEFVA	DAPK1	171	P53355
ADLFEQKVVFSGFGP	MLLT6	391	P55198
FPIEEAQGQFLFIVG	BAAT	311	Q14032
GGKQFVLQCESDPEF	GRK3	626	P35626
KEFQEGLKIFFPGVS	BCHE	376	P06276
VFFPKVNEAGEFGLI	EGFL6	366	Q8IUX8
GFKTAPDQFIGIFAQ	ACSL1	141	P33121
FTFFNKTGLFQDVGP	ADGRG6	746	Q86SQ4
FNSQFGLVDIPVEFK	ATP13A1	1156	Q9HD20
GGFVPNFQLFEKGDV	GPX3	126	P22352
QDFFGLAFPGSVLKE	ABCA1	2156	O95477
FPVQGTVVFGDQEFS	ADGRV1	941	Q8WXG9
QNDSPFGVFGFEEKT	ADGRV1	4026	Q8WXG9
PFNEGVILNEKSFQG	ABCB10	476	Q9NRK6
NVKNFFPIAGLEFSE	DMXL2	2521	Q8TDJ6
SVIFVNNFAFGPEVD	DOT1L	236	Q8TEK3
REPGLGFSFEFTEQQ	ACADM	31	P11310
SKFLQGVGFNPFQER	RAD54L2	681	Q9Y4B4
QNEEPVFSRDGSKFF	DPP10	371	Q8N608
PSGVFSLEFQDFVNK	MAP2K1	326	Q02750
AFPGIESKVDAVFQQ	MMP8	416	P22894
IPGDNKQVVSEGFYF	RAG2	331	P55895
FVHQASFKFGQGDLP	RANBP2	1451	P49792
LGFSEKQELQPFLFG	OR7A2P	16	Q8NGA2
NQNPKRAGEPFTEFF	IQCK	176	Q8N0W5
FSAGPKVNGTFQADF	KIR2DS2	171	P43631
NFQGIGPKIDAVFYS	MMP12	421	P39900
FITEGGKNPQHFQDF	PIK3C2G	1081	O75747
FFVNFVVGQDPGSDV	LGALS4	46	P56470
FLEPGNFGESFKAIN	RBL2	321	Q08999
GVEPKVDAVLQAFGF	MMP10	431	P09238
DTAPGIVEIQGAFFK	OTOA	516	Q7RTW8
PFGIFVVDKNTGDIN	DSG3	96	P32926
FSAGPKVNGTFQADF	KIR2DL2	171	P43627
QQEGFKGTFPDAREQ	NONO	366	Q15233
TAGNPFFERFGIVVA	DOLK	101	Q9UPQ8
AGLEPFFDFIVSING	GORASP2	31	Q9H8Y8
FDVQIPKGAFISNFS	ITIH2	106	P19823
RFQKENPGFDFSGAE	NUDCD2	126	Q8WVJ2
FSAGPKVNGTFQADF	KIR2DL3	171	P43628
GVLDFFFQKPSGFLT	MYO16	836	Q9Y6X6
QNQKFGFEVGPVCFL	COL11A1	1791	P12107
ASPEVNGFFGAKGVA	PGS1	411	Q32NB8
RFEGQFSINKVPGNF	ERGIC1	116	Q969X5
VQKNIEFFGGDPSSV	CES5A	206	Q6NT32
GNEFKNIFGTPEFVA	DAPK3	171	O43293
GQEGFIPFNFVAKAN	LCK	106	P06239
FSAGPKVNGTFQADF	KIR2DS3	171	Q14952
KVVFQEFTDGSFTQP	F8	1751	P00451
DGDVGVFPLEFNKNS	TWNK	611	Q96RR1
PGQKDVNGIAQFFLD	OVOS2	121	Q6IE36
DVKDGVNQAAPAFGF	NUP42	206	O15504
KIQPDEFFGIFDQFL	DAAM1	966	Q9Y4D1
GERIQFGPNVNFVFE	DYNC2H1	2081	Q8NCM8
LKDQASQDGFFGPVF	DYNC2H1	2751	Q8NCM8
GFEPTLEALFGKQGF	APOB	696	P04114
LEALFGKQGFFPDSV	APOB	701	P04114
KDGATIPFQGVFSIF	CDHR2	976	Q9BYE9
IDIFFTPKQEGDVNF	HYDIN	4151	Q4G0P3
EGTFSFEFQPLKAGE	HYDIN	4886	Q4G0P3
PTGGENFTFQIYKAD	HAT1	151	O14929
TFKEGVQEVFFPSDL	GRHL1	216	Q9NZI5
VKFQQRFVFPVQFGG	C2CD3	616	Q4AC94
SEGLGQFAQDPKFIE	CACNA1C	2126	Q13936
KSPEGFFQVAFNGLD	CD1C	126	P29017
GVEFKNIFGTPEFVA	DAPK2	181	Q9UIK4
INSGGKLPNFGFVVF	G3BP1	371	Q13283
NVGQFSGFPFEKGSV	DEK	126	P35659
KGQAPVFDVFEAFLN	ARFGEF3	1326	Q5TH69
IEVDGFLFPKNTQFV	CYP27A1	411	Q02318
DPFKQFNIDFDTGVL	FAT3	2226	Q8TDW7
DGLFKVFTPEEAVNF	ILKAP	326	Q9H0C8
FQPGKAIGFVKDVAN	CTSH	216	P09668
VQNEQGFVEFKISGP	SLC44A1	366	Q8WWI5
FVANFDENDPKTFEG	GDI1	146	P31150
GGFVPSFQLFEKGDV	GPX5	126	O75715
SGFVPSFQLFEKGDV	GPX6	126	P59796
FKEQGVTFPSGDIQE	FASN	256	P49327
QFGQEKDVFAPRFSN	SCAF8	76	Q9UPN6
EQFKAQFPFGGLLDS	SALL3	641	Q9BXA9
FNDAEPAKGNLFIGV	CFAP47	1476	Q6ZTR5
AQGQFSGPFVIDKGV	PKD1L1	1401	Q8TDX9
VFEVFEETPQGSFVG	CDH19	376	Q9H159
FEKGVFDEKGNFLVP	PHYHD1	81	Q5SRE7
DSDKLFPAFGFGAQV	CPNE1	331	Q99829
LVDPYVQVFFAGQKG	OTOF	451	Q9HC10
PQFKQVFEISSGEGF	PDCL	156	Q13371
GFGTNNKIFLEFEEP	PAOX	316	Q6QHF9
EVNFTFEGETGKNPD	LXN	86	Q9BS40
DFFKPQDQIAVGEDG	NMRK2	36	Q9NPI5
DPEGKITGEAFVQFA	HNRNPF	146	P52597
GEGARKFVFFNIPQI	MRPS25	41	P82663
SQEDFFINGNIKVFP	SPEF2	1431	Q9C093
ALQDFKEGNAIFTFP	SQOR	181	Q9Y6N5
KLAQIFFNGFAVPEA	SMYD4	746	Q8IYR2
QGAFAQPQVSGEEKF	TEX14	1116	Q8IWB6
YQGGKFQFETEVPDA	UBE2F	76	Q969M7
PGNFQGTLDAFFKII	SLC25A40	81	Q8TBP6
VFDGAKAFVEFSRNP	TDRD9	806	Q8NDG6
KGAENFDKFFTRGQP	PRKCA	621	P17252
SQIGGEFQSFPKVFQ	SLC25A51	241	Q9H1U9
GQFFQPFDFKVSDIR	ITIH3	811	Q06033
FLSFKLVQGGVFQEE	OPLAH	881	O14841
FIGQNKSFFGPLELV	RUFY1	166	Q96T51
FRDPFSGKQVSVFQA	EPPK1	1011	P58107
FTDQFQFADGKPGDQ	PLXDC2	21	Q6UX71
NFEGIVADVEPFGFA	SIPA1L2	966	Q9P2F8
NVPFFKVGSGDTNNF	NANS	126	Q9NR45
VVFFGDTVNPDKVDF	SIRT4	231	Q9Y6E7
SQIGGEFQSFPKVFQ	SLC25A52	241	Q3SY17
KPSVFSGLLGFEDNF	OCRL	141	Q01968
ELGFSKVFQAENPFD	RRM2B	296	Q7LG56
GFQEGPLNFAPTFKF	INPP5J	646	Q15735
FAAQGPAGAEKLAAF	VPS51	326	Q9UID3
EGAEGPSDTKQFFLQ	ZNF516	371	Q92618
KEEVFLGAFQFQPEN	SUN5	306	Q8TC36
DSEKDGGPQFAEVFV	YIPF6	111	Q96EC8
VELFPNGQSVGEKIF	SFTPD	251	P35247
KDRVGGFPNFLSNAF	NUDT16L1	151	Q9BRJ7
VPEGQFDSFVVQFKD	TNXB	1696	P22105
FDHFLVQFKNGDGQP	TNXB	2221	P22105
VFGTGASKHFQDFIP	TMEM135	426	Q86UB9
NETHFTGNEVGFFKP	TM2D1	96	Q9BX74
FFPENGVSDFQKAQI	THNSL1	406	Q8IYQ7
ISNFFAKIPFEEANG	SENP6	576	Q9GZR1
GFPEKSDIFDVDAGQ	VPS13C	2446	Q709C8
KVSNIFDDPLNAFGG	WASHC2A	1326	Q641Q2
ETGAISFVQLFDPGF	PLD2	251	O14939
SFVQLFDPGFEVQVG	PLD2	256	O14939
VVDVKFGGAAVFPNQ	TYMP	231	P19971
PGGFISNKFAANRVF	SLC17A8	146	Q8NDX2