Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of canonical Wnt signaling pathway	APC2 DACT3 FRMD8 TPBGL FRMD8P1 SHISA6	2.79e-05	154	79	6	GO:0090090
Domain	FGF	FGF2 FGF3	3.86e-03	22	79	2	SM00442
Domain	FGF	FGF2 FGF3	3.86e-03	22	79	2	PF00167
Domain	HBGF_FGF	FGF2 FGF3	3.86e-03	22	79	2	PS00247
Domain	Fibroblast_GF_fam	FGF2 FGF3	3.86e-03	22	79	2	IPR002209
Domain	IL-1_fam/FGF_fam	FGF2 FGF3	4.22e-03	23	79	2	IPR028142
Domain	EGF_CA	TPO SCUBE1 NOTCH3	5.79e-03	86	79	3	PF07645
Domain	EGF_Ca-bd_CS	TPO SCUBE1 NOTCH3	8.08e-03	97	79	3	IPR018097
Pathway	REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	NCSTN NEURL1B NOTCH3	1.15e-04	25	54	3	M27879
Pathway	REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3	NCSTN NOTCH3	2.99e-04	7	54	2	MM15612
Pathway	REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3	NCSTN NOTCH3	3.97e-04	8	54	2	M27887
Pathway	REACTOME_FGFR1B_LIGAND_BINDING_AND_ACTIVATION	FGF2 FGF3	3.97e-04	8	54	2	M27063
Pathway	REACTOME_FGFR1B_LIGAND_BINDING_AND_ACTIVATION	FGF2 FGF3	3.97e-04	8	54	2	MM14725
Pathway	REACTOME_FGFR2B_LIGAND_BINDING_AND_ACTIVATION	FGF2 FGF3	3.97e-04	8	54	2	MM14729
Pubmed	The int-2 gene product acts as a growth factor and substitutes for basic fibroblast growth factor in promoting the differentiation of a normal mouse mammary epithelial cell line.	FGF2 FGF3	5.63e-06	2	83	2	1376141
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	CYC1 RCC1L POLG CHDH ACSS1 FDX1 ABCB6 NUBPL MMAB CTU1 NT5M PPOX	7.06e-06	1047	83	12	18614015
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	CYC1 POLG CHDH ACSS1 FDX1 ABCB6 NUBPL MMAB CTU1 NT5M PPOX	1.26e-05	926	83	11	20877624
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	CYC1 RCC1L POLG NADK2 CHDH ACSS1 FDX1 ABCB6 NUBPL MMAB NT5M PPOX	1.59e-05	1136	83	12	34800366
Pubmed	Expression of Apc2 during mouse development.	APC2 NOTCH3	1.69e-05	3	83	2	15018807
Pubmed	Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.	TNFRSF10A CBLB	1.69e-05	3	83	2	22447040
Pubmed	FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.	FRMD8 FRMD8P1	1.69e-05	3	83	2	37527040
Pubmed	The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.	FRMD8 FRMD8P1	1.69e-05	3	83	2	36720499
Pubmed	Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.	COL8A2 ZNF469	3.37e-05	4	83	2	22814818
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	CYC1 RCC1L ATXN2 ACSS1 FDX1 ABCB6 MMAB	3.70e-05	382	83	7	29222160
Pubmed	FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.	FRMD8 FRMD8P1	5.60e-05	5	83	2	29897336
Pubmed	iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.	FRMD8 FRMD8P1	5.60e-05	5	83	2	29897333
Pubmed	A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.	NCSTN NOTCH3	5.60e-05	5	83	2	21562564
Pubmed	A candidate model for Angelman syndrome in the mouse.	MKRN3 OCA2	5.60e-05	5	83	2	9195990
Pubmed	Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7.	FGF3 OCA2	5.60e-05	5	83	2	8499656
Pubmed	FGF signaling in mouse gastrulation and anteroposterior patterning.	FGF2 FGF3	8.39e-05	6	83	2	9598344
Pubmed	Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.	FGF2 FGF3	8.39e-05	6	83	2	8622701
Pubmed	Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse.	MKRN3 OCA2	8.39e-05	6	83	2	8095339
Pubmed	Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.	FRMD8 FRMD8P1	8.39e-05	6	83	2	29776906
Pubmed	Chromosomal localizations of mouse Fgf2 and Fgf5 genes.	FGF2 FGF3	1.17e-04	7	83	2	1543906
Pubmed	MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field.	MEF2B HAND1	1.17e-04	7	83	2	16680724
Pubmed	Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.	POLG NADK2 ACSS1 NUBPL MMAB	1.42e-04	207	83	5	31056398
Pubmed	Establishment of the mouse chromosome 7 region with homology to the myotonic dystrophy region of human chromosome 19q.	PRKCG OCA2	1.56e-04	8	83	2	1970795
Pubmed	Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse.	FGF2 FGF3	2.00e-04	9	83	2	15830353
Pubmed	Embryonic retinoic acid synthesis is essential for early mouse post-implantation development.	FGF3 HAND1	2.00e-04	9	83	2	10192400
Pubmed	The expression of fibroblast growth factors and their receptors in the embryonic and neonatal mouse inner ear.	FGF2 FGF3	2.00e-04	9	83	2	11335076
Pubmed	Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.	HAND1 NOTCH3	2.50e-04	10	83	2	23665443
Pubmed	Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes.	HMX1 NOTCH3	2.50e-04	10	83	2	10198174
Pubmed	Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor.	FGF2 FGF3	3.05e-04	11	83	2	18199118
Pubmed	Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.	MEF2B HAND1	3.05e-04	11	83	2	9162005
Pubmed	Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis.	FGF2 FGF3	3.05e-04	11	83	2	15108315
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	CYC1 TPO POLG NADK2 FDX1 NT5M PPOX	3.21e-04	542	83	7	14651853
Pubmed	Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.	FGF2 PRKCG	3.66e-04	12	83	2	11141237
Pubmed	Fibroblast-growth-factor receptor mutations in human skeletal disorders.	FGF2 FGF3	3.66e-04	12	83	2	8585128
Pubmed	Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q.	PRKCG OCA2	3.66e-04	12	83	2	8288260
Pubmed	A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCR.	FGF2 FGF3	4.31e-04	13	83	2	9385055
Pubmed	Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development.	FGF2 FGF3	4.31e-04	13	83	2	8883961
Pubmed	Receptor specificity of the fibroblast growth factor family.	FGF2 FGF3	4.31e-04	13	83	2	8663044
Pubmed	Nomenclature guidelines for X-linked mental retardation.	IQSEC2 ARX	4.31e-04	13	83	2	1605216
Pubmed	Cis-regulatory control of corticospinal system development and evolution.	SOX12 PRKCG	4.31e-04	13	83	2	22678282
Pubmed	Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.	TPO ATXN2	4.31e-04	13	83	2	24586183
Pubmed	JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.	NCSTN NOTCH3	4.31e-04	13	83	2	34990407
Pubmed	Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells.	FGF2 FGF3	5.03e-04	14	83	2	17133345
Pubmed	NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.	ILF3 ATXN2 KRT82 CHTOP	5.30e-04	155	83	4	33838681
Pubmed	Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.	FGF3 PRKCG	5.79e-04	15	83	2	1460423
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	MBOAT7 POLG NADK2 ACSS1 NUBPL MMAB	6.43e-04	438	83	6	32628020
Pubmed	Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice.	FGF2 FGF3	6.61e-04	16	83	2	11731698
Pubmed	Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.	MKRN3 OCA2	6.61e-04	16	83	2	8601494
Pubmed	Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.	ATXN2 PRKCG	7.48e-04	17	83	2	15148151
Pubmed	Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus.	FGF2 FGF3	7.48e-04	17	83	2	16900517
Pubmed	Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea.	FGF3 ECEL1	7.48e-04	17	83	2	26160903
Pubmed	Foxh1 is essential for development of the anterior heart field.	MEF2B HAND1	8.40e-04	18	83	2	15363409
Pubmed	Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.	HAND1 ECEL1 HMX1	8.44e-04	77	83	3	29445148
Pubmed	Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.	ATXN2 OCA2	9.37e-04	19	83	2	22561518
Pubmed	Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.	FGF2 FGF3	9.37e-04	19	83	2	16597617
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	CYC1 RCC1L PNN ATXN2 CD2BP2 ZBTB10 ZNF768	1.12e-03	670	83	7	22990118
Pubmed	Phospholipase C-gamma as a signal-transducing element.	FGF2 FGF3	1.15e-03	21	83	2	10579907
Pubmed	Notch signaling maintains Leydig progenitor cells in the mouse testis.	ARX NOTCH3	1.15e-03	21	83	2	18927153
Pubmed	Functional phylogeny relates LET-756 to fibroblast growth factor 9.	FGF2 FGF3	1.15e-03	21	83	2	15199049
Pubmed	Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development.	FGF2 FGF3	1.26e-03	22	83	2	11900978
Pubmed	An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.	FGF3 NOTCH3	1.26e-03	22	83	2	29140246
Pubmed	Expression of members of the Fgf family and their receptors during midfacial development.	FGF2 FGF3	1.26e-03	22	83	2	11165488
Pubmed	Expression of FGFs during early mouse tongue development.	FGF2 FGF3	1.26e-03	22	83	2	26748348
Pubmed	Genome-wide association study identifies five new breast cancer susceptibility loci.	FGF3 MYEOV	1.26e-03	22	83	2	20453838
Pubmed	Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development.	ARX NOTCH3	1.38e-03	23	83	2	28036337
Pubmed	FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.	FGF2 FGF3	1.38e-03	23	83	2	23322300
Pubmed	Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.	FGF2 FGF3	1.50e-03	24	83	2	12421715
Pubmed	Spatiotemporal regulation of GLI target genes in the mammalian limb bud.	SCUBE1 PKDCC FRMD8 FRMD8P1	1.55e-03	207	83	4	26238476
Pubmed	Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.	FGF2 FGF3	1.63e-03	25	83	2	11294897
Pubmed	Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.	FGF2 PRKCG	1.63e-03	25	83	2	15689238
Pubmed	Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.	FGF2 HMX1	1.63e-03	25	83	2	11698278
Pubmed	FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation.	FGF2 FGF3	1.63e-03	25	83	2	20040496
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MKRN3 PNN ATXN2 MEX3B NOTCH3	1.69e-03	358	83	5	32460013
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	CDR1 ARX	1.76e-03	26	83	2	10920247
Pubmed	Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.	FGF2 FGF3	1.76e-03	26	83	2	20348033
Pubmed	IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.	FGF2 FGF3	1.76e-03	26	83	2	15071597
Pubmed	Specification of CNS macrophage subsets occurs postnatally in defined niches.	FGF2 NOTCH3	1.90e-03	27	83	2	35444273
Pubmed	Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development.	FGF2 FGF3	1.90e-03	27	83	2	19544582
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	NADK2 NUBPL CHTOP	1.95e-03	103	83	3	29539633
Pubmed	Specification of jaw identity by the Hand2 transcription factor.	HAND1 HMX1	2.04e-03	28	83	2	27329940
Pubmed	Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.	FGF2 HAND1	2.19e-03	29	83	2	17573777
Pubmed	FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system.	FGF2 FGF3	2.19e-03	29	83	2	21876757
Pubmed	Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice.	FGF2 FGF3	2.19e-03	29	83	2	34929174
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SHANK1 MBOAT7 APC2 ARX SIPA1 NOTCH3	2.25e-03	560	83	6	21653829
Pubmed	DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal.	SHANK1 HAND1	2.34e-03	30	83	2	36460641
Cytoband	11q13	FGF3 FRMD8 MYEOV SIPA1	7.15e-05	118	85	4	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	LRFN4 FGF3 FRMD8 MYEOV TPBGL SIPA1	2.05e-04	454	85	6	chr11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	PTPRN SPEG ABCB6	1.81e-03	129	85	3	chr2q35
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SCUBE1 SPEG DACT3 IQCJ-SCHIP1 MEX3B NOTCH3	6.15e-07	159	85	6	7cda111bb98f1241989e49d490bdf51a712ea589
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCUBE1 GRID2IP PTPRN SPEG PKDCC	6.33e-06	136	85	5	a2063abe2d7c3277bfbe1514c8c66363cf04b248
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCUBE1 GRID2IP PTPRN SPEG PKDCC	6.56e-06	137	85	5	8e2fa2ef8becace96a68bb85c002329110902fbb
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CABP1 SPEG FRMD8 LTB CTU1	1.62e-05	165	85	5	475905d608fac628960188ae4a18010b8097417e
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL8A2 MEF2B ACSS1 LTB ALKAL2	1.81e-05	169	85	5	c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL8A2 MEF2B ACSS1 LTB ALKAL2	1.92e-05	171	85	5	20ac3de9c164b409b70a30a8b6544ea491ef7c0e
ToppCell	Mild/Remission-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CDR1 PNN ZBTB10 LTB CBLB	2.03e-05	173	85	5	694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL8A2 SPEG FGF2 OCA2 NOTCH3	2.87e-05	186	85	5	d4e327cc1d7b618654ffe0ff6475fe8e8cc5cb01
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG DACT3 TSKS SHISA6 NOTCH3	2.95e-05	187	85	5	59313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPEG DACT3 TSKS SHISA6 NOTCH3	2.95e-05	187	85	5	2591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CABP1 SPEG DACT3 NEURL1B NOTCH3	3.87e-05	198	85	5	7dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SCUBE1 SPEG DACT3 PKDCC NOTCH3	3.87e-05	198	85	5	1e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CABP1 SPEG ABCB6 MEX3B NOTCH3	3.87e-05	198	85	5	0f1feed8a37293ae02465909f99548ab58dc7ce5
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CABP1 SPEG DACT3 NEURL1B NOTCH3	3.96e-05	199	85	5	2c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Thalamus / BrainAtlas - Mouse McCarroll V32	GRID2IP PRKCG NEURL1B SHISA6	4.05e-05	100	85	4	20675fc2ffc5ab63047d38da083b50d470f3db19
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Thalamus / BrainAtlas - Mouse McCarroll V32	GRID2IP PRKCG NEURL1B SHISA6	4.05e-05	100	85	4	1de3895e16f14ff32b901b18ce14d965afaa7e76
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora\|Thalamus / BrainAtlas - Mouse McCarroll V32	GRID2IP PRKCG NEURL1B SHISA6	4.05e-05	100	85	4	ff1bdb511700a041a90034d1d30dfc25f51d6c82
ToppCell	Sigmoid-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	SOX12 FRMD8 MYEOV NUBPL CBLB	4.06e-05	200	85	5	09deb831fc2c8a8867cc850f3aa094a5e48489ff
Disease	chronic myeloid leukemia (implicated_via_orthology)	NCSTN SIPA1	7.04e-05	5	79	2	DOID:8552 (implicated_via_orthology)
Disease	refractive error, self reported educational attainment	ECEL1 ALKAL2 SHISA6	1.04e-04	34	79	3	EFO_0004784, MONDO_0004892
Disease	Urogenital Abnormalities	APC2 FGD1	1.47e-04	7	79	2	C0042063
Disease	Oxidative Phosphorylation Deficiencies	POLG NUBPL	2.52e-04	9	79	2	C0949856
Disease	Mitochondrial Respiratory Chain Deficiencies	POLG NUBPL	2.52e-04	9	79	2	C0949857
Disease	Electron Transport Chain Deficiencies, Mitochondrial	POLG NUBPL	2.52e-04	9	79	2	C0949855
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	IQSEC2 ARX	2.52e-04	9	79	2	DOID:0050776 (implicated_via_orthology)
Disease	Seizures	POLG RHOBTB2 APC2 FGF2 NOTCH3	3.04e-04	218	79	5	C0036572
Disease	renal sinus adipose tissue measurement	SLC15A4 FDX1	5.42e-04	13	79	2	EFO_0004864
Disease	cataract	MYEOV OCA2 HMX1 MMAB	5.69e-04	141	79	4	MONDO_0005129
Disease	acetate measurement	ATXN2 ACSS1	1.30e-03	20	79	2	EFO_0010112
Disease	response to benznidazole	HAND1 OCA2	1.30e-03	20	79	2	EFO_0600031
Disease	eye measurement	ZNF469 ATXN2	2.38e-03	27	79	2	EFO_0004731

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGRGVGRLLGSLRGL	ACSS1	6	Q9NUB1
LSPLLPRGGGRGSRG	CTAGE1	516	Q96RT6
RAGSSGLLRNRGPGG	FDX1	31	P10109
LPLAGLAGRVGTARG	ABCB6	86	Q9NP58
RGAGLPGARARGLLC	CYC1	16	P08574
RPGDGARLQRVLGLG	CABP1	11	Q9NZU7
RPKLSGRLGLLGRRG	CDR1	156	P51861
SGESLPGAGGRRLRG	CDAN1	141	Q8IWY9
RGLGRPGALARGALG	CHDH	6	Q8NE62
LVAGARLGRRLSGPG	RCC1L	6	Q96I51
RLGRRLSGPGLGRGH	RCC1L	11	Q96I51
LVAGKRRLPRGAGGA	OCA2	31	Q04671
GGSGADPGSRGLLRL	NCSTN	6	Q92542
RPGGLGGSGGLRLLL	PTPRN	6	Q16849
PAARPRLGGDGGGRR	NADK2	31	Q4G0N4
LRGRGARAGPGEQGL	FRMD8	216	Q9BZ67
GNGGGAFRPGSRRLL	ATXN2	81	Q99700
LGRPGRAPRRGAGGH	IQSEC2	1336	Q5JU85
PGARLRRDAGGRGGV	FGF3	21	P11487
GLFAALRGRGARAGP	FRMD8P1	211	Q9BZ68
GGRGGNPRKGRILGI	CBLB	11	Q13191
QARLLALSGPGGGRG	PNN	41	Q9H307
RGGGLDPLIRGLLAR	TPO	531	P07202
ARARALLGPGALGLG	HMX1	81	Q9NP08
SLAQLGGPGRAGLGR	NOTCH3	2136	Q9UM47
VALRSPGRGLLAGAG	MYEOV	201	Q96EZ4
LGLGLALGGGSPSRR	MBOAT7	441	Q96N66
GALRLRGGAPGSAAG	LCA10	26	Q71F78
SPGRLEALGGRLGRR	HAND1	81	O96004
EALGGRLGRRKGSGP	HAND1	86	O96004
GGGRGLRALGCLGSR	KRT82	41	Q9NSB4
RVLALGGRGPGGRPH	PRKCG	401	P05129
RGRGGLRLGLRGPLR	MROH6	511	A6NGR9
LSGRAPGGGRLGERR	HSPA12B	261	Q96MM6
LRRLLARPGGGPGGA	ECEL1	161	O95672
GRRSDLPGGLAGPRG	MEF2B	206	Q02080
VAGALRRLGARGGGK	CD2BP2	171	O95400
AGPGARGGRLGLVRV	APC2	1961	O95996
RRASLLVGGLAGPGG	GRID2IP	261	A4D2P6
LGGRVDRLLRGLGGA	BORCS6	271	Q96GS4
AGRLGPLGRRGPAGG	DACT3	526	Q96B18
GRGGARLPLRRGGPA	B3GAT2	46	Q9NPZ5
DGLNRGRPRLAIGKG	CTU1	306	Q7Z7A3
GRPRLAIGKGRRGLD	CTU1	311	Q7Z7A3
GLRGEPGIRGDQGLR	COL8A2	141	P25067
PPNLRGRGRGGSIRG	ILF3	636	Q12906
RRLYGPGGGRLLQGA	ARX	86	Q96QS3
GSRLGDRGRGRALPG	FGF2	76	P09038
DRGRGRALPGGRLGG	FGF2	81	P09038
GPEGARRGLGVLRAL	FANCE	36	Q9HB96
RGGGALARAAGRGLL	DCBLD1	6	Q8N8Z6
GAGLALGRLLGGGRA	PRDM13	321	Q9H4Q3
LGRLLGGGRACGRPG	PRDM13	326	Q9H4Q3
LGTRGRLAGGSGLPG	SCUBE1	16	Q8IWY4
GGAGERAPLLGARRA	SLC15A4	6	Q8N697
SGLPRSRLGFLGLGG	FAM87A	131	P0C7U9
RLLLFGGVSLRAGGG	NUBPL	6	Q8TB37
LGSRLGLGSRLGLRG	MMAB	6	Q96EY8
LARRVRSDPGGGGLA	MEX3B	456	Q6ZN04
AVPAGRRGAAGGLGL	NT5M	16	Q9NPB1
RRGAAGGLGLAGGRA	NT5M	21	Q9NPB1
AGPGVRRGGLLGRGN	POLG	211	A0A3B3IS91
RRGGLLGRGNLPHIG	POLG	216	A0A3B3IS91
GPGRRGGRGELARQI	PKDCC	46	Q504Y2
LLRGAPGLGVRGGRA	PKDREJ	41	Q9NTG1
PGLGVRGGRALLSLR	PKDREJ	46	Q9NTG1
GRGSGAGLLRALGER	PRR20G	81	P0DPQ3
GLLARRGSGSALGGP	FGD1	41	P98174
LRGNGTGYLPGRGRV	RHOBTB2	371	Q9BYZ6
GGGTALRLALGRLGR	SFT2D3	191	Q587I9
LRLALGRLGRGAGLA	SFT2D3	196	Q587I9
GLPSLGGRRRAAPRG	SIPA1	556	Q96FS4
RAGGALARGGRELNG	SHISA6	46	Q6ZSJ9
GRRSGRGPAAGGLCL	IQCJ-SCHIP1	266	B3KU38
AGLRLRLLAAGCGPG	PHAF1	211	Q9BSU1
KLRGRALGASGGLRP	SHANK1	1756	Q9Y566
GLLLVLGAAGRGRGG	ALKAL2	11	Q6UX46
PIGALARGAIGGRGL	CHTOP	91	Q9Y3Y2
GLPRGGLRGGRATRT	CHTOP	111	Q9Y3Y2
LGPRGIRPAGALGAR	PPOX	56	P50336
HLRRGGLRPAPASGG	MKRN3	66	Q13064
GLRGPLLESLGGRAR	SPEG	2086	Q15772
QLPGRGGRRAAGGPL	SOX12	141	O15370
GGDVLLGINGRPRGR	NEURL1B	391	A8MQ27
LGLTGALRGPGRRGG	ZNF768	236	Q9H5H4
ALRLLGGLGGRVDGF	TSKS	351	Q9UJT2
RKLGPGAGAGFGVLR	PHF23	186	Q9BUL5
SAGRIEPRGGGRGAL	TNFRSF10A	41	O00220
RGQARRSLGDLPGGL	ZNF469	3176	Q96JG9
RALGGGAFRGLPALR	TPBGL	131	P0DKB5
GAGGGANSLLLRRGR	PHLPP1	111	O60346
LGGGAGGPLLAERNR	ZBTB10	106	Q96DT7
GPRGTRAGGLALGRS	TCF23	61	Q7RTU1
RGGRALARPRGGSGL	TMEM271	256	A0A286YF58
LEGRGGRLQGRGSLL	LTB	6	Q06643
ALLVRGRGAGNGRLP	LRFN4	536	Q6PJG9