Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Kinase-like_dom	EPHB2 STK36 WDR81 TEK MAP3K6 KSR1 CSNK1A1L CSNK1A1 CSNK1G2 ULK4 PRKDC EPHB1	7.67e-05	542	109	12	IPR011009
Domain	HEAT	STK36 PPP2R1B MROH1 PRKDC	1.75e-04	48	109	4	PF02985
Domain	HEAT	STK36 PPP2R1B MROH1 PRKDC	3.65e-04	58	109	4	IPR000357
Domain	Prot_kinase_dom	EPHB2 STK36 TEK MAP3K6 KSR1 CSNK1A1L CSNK1A1 CSNK1G2 ULK4 EPHB1	5.82e-04	489	109	10	IPR000719
Domain	SAM/pointed	EPHB2 ANKS6 PPFIBP2 MAP3K6 EPHB1	6.16e-04	117	109	5	IPR013761
Domain	PROTEIN_KINASE_DOM	EPHB2 STK36 TEK MAP3K6 KSR1 CSNK1A1L CSNK1A1 CSNK1G2 ULK4 EPHB1	6.19e-04	493	109	10	PS50011
Domain	Znf_RING	RAG1 RNF31 MARCHF6 RNF183 KMT2D RNF10 ANKIB1 RNF145	6.52e-04	326	109	8	IPR001841
Domain	SAM_1	EPHB2 ANKS6 PPFIBP2 EPHB1	6.71e-04	68	109	4	PF00536
Domain	HEAT_REPEAT	PPP2R1B MROH1 ULK4 PRKDC	7.48e-04	70	109	4	PS50077
Domain	PROTEIN_KINASE_ATP	EPHB2 STK36 TEK MAP3K6 CSNK1A1L CSNK1A1 CSNK1G2 ULK4 EPHB1	1.47e-03	459	109	9	PS00107
Domain	ZF_RING_1	RAG1 RNF31 RNF183 KMT2D RNF10 ANKIB1 RNF145	1.60e-03	291	109	7	PS00518
Domain	Protein_kinase_ATP_BS	EPHB2 STK36 TEK MAP3K6 CSNK1A1L CSNK1A1 CSNK1G2 EPHB1	1.71e-03	379	109	8	IPR017441
Domain	SAM	EPHB2 ANKS6 PPFIBP2 EPHB1	1.76e-03	88	109	4	SM00454
Domain	ZF_RING_2	RAG1 RNF31 RNF183 KMT2D RNF10 ANKIB1 RNF145	1.83e-03	298	109	7	PS50089
Domain	-	STK36 PPP2R1B MROH1 TELO2 ULK4 PRKDC	1.93e-03	222	109	6	1.25.10.10
Domain	RING	RAG1 RNF31 RNF183 KMT2D RNF10 ANKIB1 RNF145	2.08e-03	305	109	7	SM00184
Domain	SAM_DOMAIN	EPHB2 ANKS6 PPFIBP2 EPHB1	2.32e-03	95	109	4	PS50105
Domain	SAM	EPHB2 ANKS6 PPFIBP2 EPHB1	2.51e-03	97	109	4	IPR001660
Domain	RECEPTOR_TYR_KIN_V_2	EPHB2 EPHB1	2.93e-03	14	109	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB2 EPHB1	2.93e-03	14	109	2	PS00790
Domain	Eph_TM	EPHB2 EPHB1	2.93e-03	14	109	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB2 EPHB1	2.93e-03	14	109	2	IPR001426
Domain	IBR	RNF31 ANKIB1	2.93e-03	14	109	2	SM00647
Domain	EPH_lbd	EPHB2 EPHB1	2.93e-03	14	109	2	SM00615
Domain	Ephrin_lbd	EPHB2 EPHB1	2.93e-03	14	109	2	PF01404
Domain	EphA2_TM	EPHB2 EPHB1	2.93e-03	14	109	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB2 EPHB1	2.93e-03	14	109	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB2 EPHB1	2.93e-03	14	109	2	IPR001090
Domain	IBR	RNF31 ANKIB1	2.93e-03	14	109	2	PF01485
Domain	EPH_LBD	EPHB2 EPHB1	2.93e-03	14	109	2	PS51550
Domain	IBR_dom	RNF31 ANKIB1	3.37e-03	15	109	2	IPR002867
Domain	-	EPHB2 ANKS6 PPFIBP2 EPHB1	3.45e-03	106	109	4	1.10.150.50
Domain	zf-RING_2	RNF183 RNF10 RNF145	3.47e-03	52	109	3	PF13639
Domain	ARM-type_fold	STK36 PPP6R1 PPP2R1B MROH1 TELO2 ULK4 PRKDC	3.74e-03	339	109	7	IPR016024
Domain	Znf_RING-CH	MARCHF6 RNF145	4.33e-03	17	109	2	IPR011016
Domain	MMR_HSR1	NOA1 GTPBP3	4.33e-03	17	109	2	PF01926
Domain	HEAT_type_2	PPP2R1B MROH1	4.33e-03	17	109	2	IPR021133
Domain	RINGv	MARCHF6 RNF145	4.33e-03	17	109	2	SM00744
Domain	-	RAG1 MARCHF6 RNF183 USP5 KMT2D RNF10 ANKIB1 RNF145	4.81e-03	449	109	8	3.30.40.10
Domain	ARM-like	STK36 PPP2R1B MROH1 TELO2 ULK4 PRKDC	5.06e-03	270	109	6	IPR011989
Domain	S_TKc	STK36 TEK MAP3K6 KSR1 CSNK1A1L CSNK1A1 CSNK1G2	5.11e-03	359	109	7	SM00220
Domain	PROTEIN_KINASE_ST	STK36 MAP3K6 KSR1 CSNK1A1L CSNK1A1 CSNK1G2 ULK4	5.34e-03	362	109	7	PS00108
Domain	GTP_binding_domain	NOA1 GTPBP3	5.41e-03	19	109	2	IPR006073
Domain	Znf_RING/FYVE/PHD	RAG1 MARCHF6 RNF183 USP5 KMT2D RNF10 ANKIB1 RNF145	5.47e-03	459	109	8	IPR013083
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	STK36 CSNK1A1L CSNK1A1 CSNK1G2 PTCH2	1.49e-05	56	79	5	M1053
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	CSNK1A1L CSNK1A1 CSNK1G2 PTCH2	9.55e-05	43	79	4	M39706
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2R1B CSNK1A1L CSNK1A1	1.30e-04	18	79	3	MM14759
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TFEB STK36 ANKS6 EPPK1 NTSR1 PPP6R1 CTDNEP1 BIRC6 LDLR MXRA7 TPCN1 KMT2D MROH1 SLC12A4 SBF1 CSNK1G2 ULK4 HES6 PRKDC	1.59e-09	1105	109	19	35748872
Pubmed	The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.	EPHB2 CSNK1A1L CSNK1A1	1.04e-06	7	109	3	17686994
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	EPHB2 SELENBP1 EMC8 COG3 CTDNEP1 LDLR B3GAT3 NUP205 MROH1 SLC12A4 DPY19L4 ANKIB1 EMC10 PRKDC RNF145	1.17e-06	1061	109	15	33845483
Pubmed	Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.	EPHB2 ELOC SPSB4	1.66e-06	8	109	3	28931592
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	RNF31 EMC8 RRBP1 REEP2 MXRA7 SLC12A4 EMC10 CERS4 VAT1 ZC3HAV1	2.30e-06	468	109	10	31056421
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	EHBP1 PPFIBP2 MARCHF6 WDR81 EMC8 BIRC6 CDC42EP3 KSR1 USP5 SLC12A4 TELO2 SCRIB	2.80e-06	719	109	12	35337019
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1A1L CSNK1A1 CSNK1G2	3.54e-06	10	109	3	25500533
Pubmed	Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.	EHBP1 KLK3	9.73e-06	2	109	2	32295536
Pubmed	Cardiac apoptosis in severe relapsing fever borreliosis.	RAG1 PRKDC	9.73e-06	2	109	2	16239571
Pubmed	Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	23354688
Pubmed	Recombinase-activating gene 1-associated expression of the myelin basic protein 1-11-specific transgenic T-cell receptor in H-2b mice.	RAG1 PRKDC	9.73e-06	2	109	2	18752298
Pubmed	During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.	RAG1 PRKDC	9.73e-06	2	109	2	12498815
Pubmed	EphB2 receptor cell-autonomous forward signaling mediates auditory memory recall and learning-driven spinogenesis.	EPHB2 EPHB1	9.73e-06	2	109	2	31633063
Pubmed	Tissue-specific distribution of mouse casein kinase I alpha mRNA.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	9522121
Pubmed	CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	37723657
Pubmed	Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	36929849
Pubmed	Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	35695793
Pubmed	Exploring the role of casein kinase 1α splice variants across cancer cell lines.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	38852281
Pubmed	Polymorphic variants of DNA repair gene XRCC3 and XRCC7 and risk of prostate cancer: a study from North Indian population.	XRCC3 PRKDC	9.73e-06	2	109	2	20590474
Pubmed	Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	23690993
Pubmed	A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity.	NOA1 REST	9.73e-06	2	109	2	21106707
Pubmed	An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment.	RAG1 PRKDC	9.73e-06	2	109	2	22147896
Pubmed	Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	36542875
Pubmed	An obesogenic diet increases atherosclerosis through promoting microbiota dysbiosis-induced gut lymphocyte trafficking into the periphery.	RAG1 LDLR	9.73e-06	2	109	2	37897726
Pubmed	Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody.	RAG1 PRKDC	9.73e-06	2	109	2	16393973
Pubmed	Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	25994086
Pubmed	Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy.	RAG1 TEK	9.73e-06	2	109	2	16314485
Pubmed	ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.	STK36 ULK4	9.73e-06	2	109	2	36989043
Pubmed	Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma.	RUVBL2 PRKDC	9.73e-06	2	109	2	25875766
Pubmed	Novel role of the Ras cascade in memory B cell response.	RAG1 PRKDC	9.73e-06	2	109	2	16111632
Pubmed	The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.	RAG1 PRKDC	9.73e-06	2	109	2	17296939
Pubmed	PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.	PPP6R1 PRKDC	9.73e-06	2	109	2	22298787
Pubmed	Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions.	RAG1 PRKDC	9.73e-06	2	109	2	14662857
Pubmed	Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	34216174
Pubmed	Hypercholesterolemia induces T cell expansion in humanized immune mice.	LDLR PRKDC	9.73e-06	2	109	2	29708512
Pubmed	Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	37108197
Pubmed	Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo.	RAG1 PRKDC	9.73e-06	2	109	2	9278319
Pubmed	Effect of different Ig transgenes on B cell differentiation in scid mice.	RAG1 PRKDC	9.73e-06	2	109	2	9088976
Pubmed	Polymorphisms of XRCC3 and XRCC7 and Colorectal Cancer Risk in Khorasan Razavi Province, Iran.	XRCC3 PRKDC	9.73e-06	2	109	2	31350979
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	EHBP1 RNF183 EMC8 COG3 USP5 TELO2 PRKDC SCRIB ZC3HAV1	1.25e-05	449	109	9	31732153
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	EHBP1 SGSM1 PPFIBP2 TTC21A COG3 RRBP1 CDC42EP3 PCYOX1L PPP2R1B EXD3 CSNK1A1 SPACA6 ANKIB1 ZFHX2 HSD11B2 ZC3HAV1	1.64e-05	1489	109	16	28611215
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	EHBP1 TFEB ANKS6 WDR81 PPP6R1 POGZ XRCC3 RUVBL2 KSR1 TELO2 CSNK1A1 RNF10 ZC3HAV1	2.29e-05	1038	109	13	26673895
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EPHB2 CACNA2D1 MARCHF6 PPP6R1 EMC8 RRBP1 LDLR B3GAT3 TPCN1 PCYOX1L USP5 DPY19L4 EMC10 SCRIB	2.40e-05	1201	109	14	35696571
Pubmed	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.	RUVBL2 TELO2 PRKDC	2.80e-05	19	109	3	20801936
Pubmed	Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice.	RAG1 PRKDC	2.91e-05	3	109	2	26168294
Pubmed	Dense granule protein 3 of Toxoplasma gondii plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8+ T cells during the chronic stage of infection.	RAG1 PRKDC	2.91e-05	3	109	2	37868957
Pubmed	Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.	EPHB2 EPHB1	2.91e-05	3	109	2	9499402
Pubmed	Completing the structural family portrait of the human EphB tyrosine kinase domains.	EPHB2 EPHB1	2.91e-05	3	109	2	24677421
Pubmed	Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	24616378
Pubmed	EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.	RAPGEF3 PRKDC	2.91e-05	3	109	2	18728186
Pubmed	DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.	RAG1 PRKDC	2.91e-05	3	109	2	28467930
Pubmed	Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.	RAG1 LDLR	2.91e-05	3	109	2	27564380
Pubmed	NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.	RAG1 PRKDC	2.91e-05	3	109	2	24798995
Pubmed	Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	25242043
Pubmed	Lymphocytes mediate TNF-alpha-induced endothelial cell adhesion molecule expression: studies on SCID and RAG-1 mutant mice.	RAG1 PRKDC	2.91e-05	3	109	2	9366433
Pubmed	Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	28655862
Pubmed	EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.	EPHB2 EPHB1	2.91e-05	3	109	2	18057206
Pubmed	SR-BI (Scavenger Receptor Class B Type 1) Is Critical in Maintaining Normal T-Cell Development and Enhancing Thymic Regeneration.	RAG1 LDLR	2.91e-05	3	109	2	30354229
Pubmed	Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.	RAG1 PRKDC	2.91e-05	3	109	2	37909039
Pubmed	Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1.	EPHB2 EPHB1	2.91e-05	3	109	2	25051176
Pubmed	Vitamin D receptor signaling inhibits atherosclerosis in mice.	RAG1 LDLR	2.91e-05	3	109	2	22638071
Pubmed	Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis.	RAG1 PRKDC	2.91e-05	3	109	2	10545405
Pubmed	Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons.	RAG1 PRKDC	2.91e-05	3	109	2	11452126
Pubmed	Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency.	RAG1 LDLR	2.91e-05	3	109	2	27903567
Pubmed	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.	RAG1 PRKDC	2.91e-05	3	109	2	21576342
Pubmed	A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.	RAG1 PRKDC	2.91e-05	3	109	2	27699249
Pubmed	Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.	EPHB2 EPHB1	2.91e-05	3	109	2	14691139
Pubmed	A Hitchhiker's guide to humanized mice: new pathways to studying viral infections.	RAG1 PRKDC	2.91e-05	3	109	2	29446074
Pubmed	CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	28878021
Pubmed	Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.	RAG1 PRKDC	2.91e-05	3	109	2	16606667
Pubmed	Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	26811327
Pubmed	Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation.	RAG1 KMT2D	2.91e-05	3	109	2	34613626
Pubmed	A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.	EPHB2 EPHB1	2.91e-05	3	109	2	23143520
Pubmed	Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to Pneumocystis lung infection.	RAG1 PRKDC	2.91e-05	3	109	2	22626807
Pubmed	Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	19805514
Pubmed	Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.	RAG1 PRKDC	2.91e-05	3	109	2	18785974
Pubmed	Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population?	XRCC3 PRKDC	2.91e-05	3	109	2	19815090
Pubmed	Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.	EPHB2 KSR1	2.91e-05	3	109	2	11940661
Pubmed	Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.	RAG1 PRKDC	2.91e-05	3	109	2	23975863
Pubmed	Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.	RAG1 PRKDC	2.91e-05	3	109	2	17015713
Pubmed	EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.	EPHB2 EPHB1	2.91e-05	3	109	2	15722342
Pubmed	A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.	RAG1 PRKDC	2.91e-05	3	109	2	23142821
Pubmed	EphB receptors couple dendritic filopodia motility to synapse formation.	EPHB2 EPHB1	2.91e-05	3	109	2	18614029
Pubmed	Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase.	EPHB2 EPHB1	2.91e-05	3	109	2	29731254
Pubmed	Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.	EPHB2 EPHB1	2.91e-05	3	109	2	35025117
Pubmed	Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.	RAG1 PRKDC	2.91e-05	3	109	2	22246028
Pubmed	Scarless skin repair in immunodeficient mice.	RAG1 PRKDC	2.91e-05	3	109	2	16808805
Pubmed	mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell.	RAG1 PRKDC	2.91e-05	3	109	2	20980458
Pubmed	EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development.	EPHB2 EPHB1	2.91e-05	3	109	2	17668899
Pubmed	Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen.	RAG1 PRKDC	2.91e-05	3	109	2	37352357
Pubmed	Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear.	EPHB2 EPHB1	2.91e-05	3	109	2	27683910
Pubmed	NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.	RAG1 PRKDC	2.91e-05	3	109	2	14557749
Pubmed	A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition.	EPHB2 EPHB1	2.91e-05	3	109	2	22622783
Pubmed	Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues.	EPHB2 EPHB1	2.91e-05	3	109	2	11532925
Pubmed	Genetic variations in DNA-repair genes (XRCC1, 3, and 7) and the susceptibility to hepatocellular carcinoma in a cohort of Egyptians.	XRCC3 PRKDC	2.91e-05	3	109	2	32281666
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RNF31 NOA1 PPP6R1 RRBP1 MAP3K6 RUVBL2 SBF1 ANKIB1 SCRIB ZC3HAV1	3.94e-05	650	109	10	38777146
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SLC43A1 DNAH2 PPP6R1 EMC8 CTDNEP1 B3GAT3 NUP205 USP5 TELO2 EMC10 PRKDC SCRIB	4.10e-05	942	109	12	31073040
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MARCHF6 POGZ RRBP1 NUP205 TPCN1 SBF1 TELO2 RNF10 ANKIB1	4.52e-05	529	109	9	14621295
Pubmed	A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.	RAG1 RUVBL2 PRKDC	5.07e-05	23	109	3	22761313
Pubmed	Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.	RAG1 PRKDC	5.82e-05	4	109	2	21030983
Interaction	TOP3B interactions	TFEB STK36 ANKS6 EPPK1 NTSR1 PPP6R1 CTDNEP1 BIRC6 LDLR MXRA7 TPCN1 KMT2D MROH1 SLC12A4 SBF1 LRRC31 CSNK1A1 CSNK1G2 ULK4 HES6 PRKDC ZC3HAV1	7.80e-06	1470	107	22	int:TOP3B
Interaction	SLC17A2 interactions	SLC43A1 MARCHF6 CTDNEP1 SLC12A4 DPY19L4	1.18e-05	56	107	5	int:SLC17A2
Interaction	OR4N2 interactions	EMC8 SLC12A4 DPY19L4 EMC10	1.61e-05	29	107	4	int:OR4N2
Interaction	TMC4 interactions	TRARG1 MARCHF6 TPCN1 SLC12A4	1.85e-05	30	107	4	int:TMC4
Cytoband	8q24.3	EPPK1 MROH1 GML SCRIB	1.59e-04	113	109	4	8q24.3
Cytoband	14q32.3	AMN XRCC3	2.48e-04	10	109	2	14q32.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ISYNA1 F2RL3 PLPPR3 PGLYRP2 LDLR CSNK1G2 GTPBP3 CERS4	6.49e-04	797	109	8	chr19p13
GeneFamily	Sterile alpha motif domain containing	EPHB2 ANKS6 PPFIBP2 EPHB1	3.76e-04	88	70	4	760
GeneFamily	Ring finger proteins	RAG1 RNF31 MARCHF6 RNF183 RNF10 RNF145	6.80e-04	275	70	6	58
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB2 EPHB1	1.30e-03	14	70	2	1095
GeneFamily	INO80 complex \|SRCAP complex	RUVBL2 NFRKB	1.50e-03	15	70	2	595
ToppCell	COPD-Myeloid-pDC\|COPD / Disease state, Lineage and Cell class	AMN GLT1D1 RRBP1 TTC39A CERS4 EPHB1	4.93e-06	177	109	6	415aa023195a7f961c09529f65cdcc7bb90eaf5d
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE KLK3 LDLR HES6 TTC39A HSD11B2	8.83e-06	196	109	6	847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TTC21A DNAH2 PLPPR3 KCNN3 ZFHX2 ULK4	9.09e-06	197	109	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE KLK3 LDLR HES6 TTC39A HSD11B2	9.09e-06	197	109	6	d624f3a105b19f19a0dd253ce8de3ed13adc1f01
ToppCell	3'-Adult\|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPPK1 SELENBP1 GNE RRBP1 UGT2A3 HSD11B2	9.36e-06	198	109	6	302adb42089ff22fffc4f01af572ca2e151f7ce7
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPTBN5 SLC12A4 PTCH2 DKK3 EPHB1	1.98e-05	134	109	5	6d97fa07f55ae20c17b9d5262e893957cccc6dba
ToppCell	Basal_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	EPHB2 EPPK1 REEP2 HSD11B2 DKK3	5.52e-05	166	109	5	aea2ae12e4746149ebc6da063ef694381c098f80
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STK36 RNF183 SSTR1 TTC39A EPHB1	5.68e-05	167	109	5	5accd0bc7c95089feb2c09376d12cd8bd3773775
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ISYNA1 EXD3 NMT2 UGT2A3 VAT1	6.53e-05	172	109	5	7fb43b3938b9a3b6935ec22d9d853e7d47b82b3c
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GLT1D1 RRBP1 CERS4 ZC3HAV1 EPHB1	7.08e-05	175	109	5	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE CSNK1G2 HES6 TTC39A SCRIB	7.08e-05	175	109	5	019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE CSNK1G2 HES6 TTC39A SCRIB	7.68e-05	178	109	5	9099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SGSM1 GLT1D1 ZFHX2 NALF2 EPHB1	7.88e-05	179	109	5	228d12ed1c8dc92aefbcea4aaf7d108783c22be0
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SGSM1 NUP205 TPCN1 KCNN3 EPHB1	7.88e-05	179	109	5	df4d0b2fe47d2c7def729b3217cb01ced01495ff
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ISYNA1 RAPGEF3 KCNN3 DKK3 VAT1	7.88e-05	179	109	5	ec1d7017da325647b629de703135a404bbdc627d
ToppCell	COPD-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	AMN GLT1D1 TTC39A CERS4 EPHB1	7.88e-05	179	109	5	29b058c5e33fda9f0d738c074bdb67ff16b9b6d5
ToppCell	IPF-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	AMN GLT1D1 TTC39A CERS4 EPHB1	8.09e-05	180	109	5	0f8567aa835d4e3a52f6631ae15216eca18a030c
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PGLYRP2 PCYOX1L RAPGEF3 SUSD5 VAT1	8.30e-05	181	109	5	382337427be3c11ecd03e9fa2c2e831a9674c6a7
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RRBP1 CDC42EP3 HES6 TTC39A HSD11B2	8.30e-05	181	109	5	dae0d106f0eee5dba538617f8ed724925ea35f17
ToppCell	critical-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CACNA2D1 F2RL3 GRIK5 EXD3 NMT2	8.30e-05	181	109	5	f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDC42EP3 RAPGEF3 HES6 TTC39A HSD11B2	8.75e-05	183	109	5	ee9c88be88221b7ad4ea9f890b17d6156fb3432e
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDC42EP3 RAPGEF3 HES6 TTC39A HSD11B2	8.75e-05	183	109	5	c52b84034503d931f7b87312d2ff86daff14152d
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 TRARG1 GRIK5 TEK RAPGEF3	9.44e-05	186	109	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	wk_20-22-Hematologic-Myeloid-Myelocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	GLT1D1 PGLYRP2 TLR8 RAPGEF3 SPACA6	9.44e-05	186	109	5	53b4ce33ae6fa32f1b56cbc62b1d7915e935afc9
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 TRARG1 GRIK5 TEK RAPGEF3	9.44e-05	186	109	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPTBN5 SLC12A4 LRRC31 PTCH2	9.50e-05	97	109	4	0d68bf2dfb9c221375b70b055f735536afb18f65
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGSM1 LGR5 SPACA6 KCNN3 EPHB1	1.04e-04	190	109	5	f50b9814a1beac67dc042a8c27dfd085ceeda3a6
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGSM1 LGR5 SPACA6 KCNN3 EPHB1	1.04e-04	190	109	5	a22a510b4a257eb0eaf09c7ae7978d3d2f07a58c
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGSM1 LGR5 SPACA6 KCNN3 EPHB1	1.04e-04	190	109	5	57c136bf6d7feafb4a220877bed0cc8fdf314db2
ToppCell	hematopoetic_progenitors-CD34+_MEP_2\|hematopoetic_progenitors / Lineage and Cell class	COG3 TPCN1 EXD3 NMT2 VAT1	1.07e-04	191	109	5	3b061dbc10918be7cbbd4453311d2c1ebf18c6b2
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RRBP1 KLK3 LRRC31 HES6 TTC39A	1.12e-04	193	109	5	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RRBP1 KLK3 LRRC31 HES6 TTC39A	1.12e-04	193	109	5	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE RRBP1 LRRC31 TTC39A HSD11B2	1.15e-04	194	109	5	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE RRBP1 LRRC31 TTC39A HSD11B2	1.15e-04	194	109	5	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLK3 LRRC31 HES6 TTC39A HSD11B2	1.18e-04	195	109	5	7ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLK3 LRRC31 HES6 TTC39A HSD11B2	1.18e-04	195	109	5	09605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-goblet\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE RRBP1 LRRC31 TTC39A HSD11B2	1.21e-04	196	109	5	c2d17630f7bfc9e727de55e093c17fddac61b61f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AMN SELENBP1 GNE RNF183 RRBP1	1.21e-04	196	109	5	2c3fbfbb08cd327cd97b3fa5a6f83b6d50771fb7
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GNE RRBP1 LRRC31 TTC39A HSD11B2	1.21e-04	196	109	5	54c30023d04e7265373647f56fc93885804938b0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CACNA2D1 SSTR1 TEK KCNK7 SUSD5	1.24e-04	197	109	5	b8dc192fc98428bbb701cc2ea57fc8ad93397785
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Cortical_neuron\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	CACNA2D1 ISYNA1 CDC42EP3 REEP2 EPHB1	1.33e-04	200	109	5	7bba2ff09349c8db3d1ccf53520b12cbf7b0abac
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT2-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMN SELENBP1 LDLR TTC39A RNF145	1.33e-04	200	109	5	65c83a3f6ee2a10bcb5b95076696232c6373a7b4
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT2-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	AMN SELENBP1 LDLR TTC39A RNF145	1.33e-04	200	109	5	40e969883bc302e8fbc6b6ab9814529dc1472902
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-AT2-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	AMN SELENBP1 LDLR TTC39A RNF145	1.33e-04	200	109	5	ad9cdc82a647d379abc713a56db0e11bb6494106
ToppCell	severe-CD163+_Monocytes_(Sample_ID1_d7)\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EPHB2 GLT1D1 DOK3 CDC42EP3 TLR8	1.33e-04	200	109	5	a3f22826f3d8f917ff0594bdadd93b60763bcaa2
ToppCell	severe-CD163+_Monocytes_(Sample_ID1_d7)\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EPHB2 GLT1D1 DOK3 CDC42EP3 TLR8	1.33e-04	200	109	5	4943fe826d5fcc3dfeb8b99a7415848f3fecc994
Computational	Neighborhood of PRKAG1	EHBP1 CTDNEP1 RUVBL2 USP5 KMT2D CSNK1G2 NFRKB	2.35e-04	224	60	7	MORF_PRKAG1
Computational	Neighborhood of DDB1	EHBP1 CTDNEP1 RUVBL2 USP5 CSNK1G2 NFRKB PRKDC	4.15e-04	246	60	7	MORF_DDB1
Computational	Genes in the cancer module 200.	EPHB2 TEK EPHB1	4.40e-04	27	60	3	MODULE_200
Drug	Prazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	EPHB2 TFEB RNF31 TPCN1 KSR1 USP5 SBF1 ZC3HAV1	4.73e-06	196	109	8	6315_DN
Drug	AC1L1BEB	GNE XRCC3 KLK3 CNDP1	1.24e-05	30	109	4	CID000001402
Drug	CKI-8	CSNK1A1L CSNK1A1 CSNK1G2	1.25e-05	10	109	3	CID000486026
Drug	di-t-butylphosphite	CSNK1A1L CSNK1A1 CSNK1G2	1.25e-05	10	109	3	CID000518693
Drug	2-amino-5-(N-ethylcarboxyamido)-pentanoic acid	CSNK1A1L CSNK1A1 CSNK1G2	1.25e-05	10	109	3	CID000194789
Drug	Asptpsa	CSNK1A1L CSNK1A1 CSNK1G2	1.25e-05	10	109	3	CID000132853
Drug	fullerene C60	EPHB2 AMN SELENBP1 F2RL3 SLC43A1 REST CTDNEP1 MAP3K6 TPCN1 USP5 PPP2R1B TELO2 RAPGEF3 CSNK1G2 SUSD5 NFRKB PTCH2 KCNN3 HSD11B2 FHIP2B	2.60e-05	1498	109	20	ctd:C069837
Drug	5-chloroisoquinoline	CSNK1A1L CSNK1A1 CSNK1G2	2.95e-05	13	109	3	CID000224933
Drug	Loracarbef [121961-22-6]; Up 200; 10.8uM; HL60; HT_HG-U133A	EPHB2 EXO5 RNF31 NTSR1 RRBP1 TPCN1 FHIP2B	4.33e-05	195	109	7	2970_UP
Drug	rapamycin; Down 200; 0.1uM; HL60; HG-U133A	TFEB AMN RRBP1 TLR8 KMT2D NFRKB EPHB1	4.62e-05	197	109	7	362_DN
Drug	Esculetin [305-01-1]; Up 200; 22.4uM; HL60; HT_HG-U133A	EPHB2 CACNA2D1 DOK3 GRIK5 RRBP1 NMT2 ULK4	4.62e-05	197	109	7	3120_UP
Drug	AC1Q5W8U	CSNK1A1L CSNK1A1 CSNK1G2	4.66e-05	15	109	3	CID000006483
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	EPHB2 GRIK5 SSTR1 SPTBN5 GML TTC39A CERS4	4.92e-05	199	109	7	3872_UP
Drug	Arecoline hydrobromide [300-08-3]; Down 200; 17uM; PC3; HT_HG-U133A	TFEB EPPK1 TPCN1 KSR1 EXD3 SBF1 TELO2	4.92e-05	199	109	7	6322_DN
Drug	Atropine-N-oxide hydrochloride [4574-60-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	EHBP1 TFEB GRIK5 XRCC3 RRBP1 SPTBN5 NMT2	4.92e-05	199	109	7	2054_UP
Disease	severe combined immunodeficiency (implicated_via_orthology)	RAG1 PRKDC	3.83e-05	3	106	2	DOID:627 (implicated_via_orthology)
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1A1L CSNK1A1	2.65e-04	7	106	2	DOID:0060807 (implicated_via_orthology)
Disease	response to acetylsalicylate	CACNA2D1 EPHB1	1.48e-03	16	106	2	GO_1903492
Disease	waist-hip ratio	EPHB2 SLC43A1 RREB1 BIRC6 CDC42EP3 REEP2 NUP205 PPP2R1B RAPGEF3 KCNN3 TTC39A HSD11B2	1.51e-03	1226	106	12	EFO_0004343
Disease	Malignant neoplasm of prostate	EPHB2 EHBP1 RAG1 RNF31 PPFIBP2 KLK3 KMT2D PRKDC	1.73e-03	616	106	8	C0376358
Disease	hydrocephalus (implicated_via_orthology)	STK36 ULK4	2.10e-03	19	106	2	DOID:10908 (implicated_via_orthology)
Disease	Severe Combined Immunodeficiency	RAG1 PRKDC	2.33e-03	20	106	2	C0085110
Disease	circadian rhythm	EXD3 RNF10 ANKIB1 EPHB1	2.88e-03	163	106	4	EFO_0004354
Disease	Ovarian Serous Adenocarcinoma	STK36 TEK	3.08e-03	23	106	2	C1335177
Disease	carnosine measurement	GRIK5 CNDP1	3.35e-03	24	106	2	EFO_0010470
Disease	suicidal ideation, suicide behaviour	AMN EXD3	3.35e-03	24	106	2	EFO_0004320, EFO_0007623

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLSQDDLETLVMPTL	PPP2R1B	246	P30154
VDMAGFAVALPLLLD	B3GAT3	251	O94766
AALPLALVLLAMRLA	CERS4	41	Q9HA82
ALTMDLAPLLLAARS	C8orf82	201	Q6P1X6
MLQDILAGELLAPVA	BIRC6	2411	Q9NR09
LILAMLDASDLASPS	GTPBP3	331	Q969Y2
LLGMLALSPAIAEEL	A2ML1	6	A8K2U0
DMLQAPLFTAEALLR	ANKIB1	246	Q9P2G1
VSDMLLPLDGELVLA	AMN	66	Q9BXJ7
LRLAMSDLTPVVDAI	HSD11B2	311	P80365
LDLGPSLLDEVLNVM	CDC42EP3	236	Q9UKI2
LTAILSPLIAEREAM	RAG1	671	P15918
VAAELLNHLLESMPL	HES6	121	Q96HZ4
LLAAPIMLDLALLTE	ISYNA1	421	Q9NPH2
NESPMLELALSLLEE	NUP205	811	Q92621
LMELVFLSLTLSDLP	EXO5	271	Q9H790
LLLLLLASAVAAMEE	EPHB1	6	P54762
LSKAELAAPQLIMLA	REST	36	Q13127
VVDLLAAASIMPLGL	GPR62	56	Q9BZJ7
ILLLESQASLPMLEE	NFRKB	386	Q6P4R8
TPLLDLMSDALILAK	NMT2	431	O60551
SDLLTLLLAMPVELY	NTSR1	111	P30989
AMVLELLGPSLEDLF	CSNK1G2	116	P78368
LLAMLLAVETFSELP	KCNK7	246	Q9Y2U2
MALASRDVEALSPLI	SLC43A1	121	O75387
LDSVELLSPDIIMNL	MAP3K6	266	O95382
RAMLAAVLEQELPAL	MAP3K6	1001	O95382
LLLPLLAAVEETLMD	EPHB2	11	P29323
MARAAPLLAALTALL	PCYOX1L	1	Q8NBM8
ENLLLLVSMASPAAA	FHIP2B	266	Q86V87
ADVDIILSIPMFLRL	KCNN3	401	Q9UGI6
IPRDLTLDALLEMNE	KSR1	126	Q8IVT5
ASLPLLMDSVIQALA	PGLYRP2	21	Q96PD5
LLPMLQSLEVLDLSI	LRRC31	221	Q6UY01
AALMLPTLGDVESLV	MOSPD1	171	Q9UJG1
LLTLPLDMLSTENLL	MARCHF6	126	O60337
LEAAALLLAVTMDPL	DOK3	46	Q7L591
LDTLMGDLLAVVASP	NALF2	221	O75949
NVLVMDLLGPSLEDL	CSNK1A1L	86	Q8N752
SPVALEAMLGLARLV	MROH1	1421	Q8NDA8
LEMLELPQERAALLS	PPFIBP2	61	Q8ND30
LSMVLDPELELADLA	SBF1	336	O95248
MNLAAADLLLALALP	F2RL3	116	Q96RI0
LVDPALLGAASMVLD	GNE	701	Q9Y223
AAILEAMDLEVPVLA	GLT1D1	256	Q96MS3
LLSLTFPRLLEAVEM	CACNA2D1	946	P54289
MAEAALLLLPEAAAE	COG3	1	Q96JB2
LVSPLLSLVAALMLA	DPY19L4	316	Q7Z388
MLLNDPDTELVRLLA	ANKS6	401	Q68DC2
APEIALELLMAANFL	ELOC	96	Q15369
ISRLLEPSDMVLLAI	EHBP1	516	Q8NDI1
LLLLLLMAVAAPSRA	EMC10	11	Q5UCC4
ALAPMLEVALTLIDS	EMC8	66	O43402
MPAELLLLLIVAFAS	GRIK5	1	Q16478
ALPALEEAMRALESL	DNAH2	3091	Q9P225
MALLALASAVPSALL	SPACA6	1	W5XKT8
EMALREPAAAAAALL	DKK3	331	Q9UBP4
LLLAMELPLVAASAT	GML	6	Q99445
LVLYMVDLLDLPDAL	NOA1	216	Q8NC60
LLCALLALTMAAVPL	LGR5	686	O75473
FLNRALESDMAPVLI	RUVBL2	311	Q9Y230
AIADELLMLSVPFLV	SSTR1	101	P30872
VLPSQMLDVEALALR	SUSD5	436	O60279
MLLDDSLLPLASDPL	TFEB	436	P19484
VTDLPTDTAMLALLR	RNF183	71	Q96D59
SLLVEMLALPEAVLE	SPATA21	316	Q7Z572
NVLVMDLLGPSLEDL	CSNK1A1	86	P48729
DLPLSMIVAIDEISL	POGZ	1116	Q7Z3K3
AVMLVFPAILSLDLR	PTCH2	541	Q9Y6C5
VLAGTISPEALLLMD	EPPK1	906	P58107
LPAARLLEDLMDELL	TELO2	781	Q9Y4R8
MPGLITDILLSLDDR	SELENBP1	306	Q13228
LSELILTENLLMALP	SCRIB	291	Q14160
ELGILIASLDMVAPI	SLC12A4	566	Q9UP95
PFALDMDADLLIGVL	STK36	991	Q9NRP7
LEEGLLDTAMLPAQL	SPTBN5	2706	Q9NRC6
EPMADLVALLGSLVD	CNDP1	271	Q96KN2
DTALLNLLPMLDALR	CTDNEP1	211	O95476
NLLPMLDALRFTADV	CTDNEP1	216	O95476
MLQLSEFDPLLREIA	RNF31	186	Q96EP0
ILELLLEAMGPDSSA	RAPGEF3	396	O95398
AFLTMLPRLEILDLS	TLR8	331	Q9NR97
QALILLDEEVMALSP	ZFHX2	331	Q9C0A1
MQDLTLIRDEDALPL	REEP2	151	Q9BRK0
AQTMEALLALLPELS	RRBP1	1061	Q9P2E9
LEQDSIIEALLPLSM	RREB1	596	Q92766
TNEELIPLLMLLSLA	PLPPR3	66	Q6T4P5
FALPDSLLVVLDMDE	SPSB4	171	Q96A44
VAALEQLVLMAPLAK	RNF10	396	Q8N5U6
MCDLLAPLLVILDDE	SGSM1	981	Q2NKQ1
EGAMDLILINSLPLV	TEK	21	Q02763
SLLLGDALMSILEPE	TTC21A	731	Q8NDW8
ELLALDVPNTMLDLF	PPP6R1	376	Q9UPN7
FLDALELSQSPMLLE	PRKDC	1746	P78527
MAVSLDDDVPLILTL	TPCN1	1	Q9ULQ1
LIPEAMTFEEAAALL	VAT1	156	Q99536
DLMAELLAVPFVLTL	UGT2A3	156	Q6UWM9
GSAAFLDLPEMEILL	TRARG1	16	Q8IXB3
MALDALLQEIALSEP	ZC3HAV1	21	Q7Z2W4
SMLEIADPIVLALGA	RNF145	356	Q96MT1
PNALLELALLLMEQD	TTC39A	546	Q5SRH9
MDLDLLDLNPRIIAA	XRCC3	1	O43542
MAELSEEALLSVLPT	USP5	1	P45974
LEILLPFVLSLMSEE	WDR81	921	Q562E7
NLEAALVLMEAAPEL	TRPV5	91	Q9NQA5
NEMAAPLLFSLLDIL	ULK4	1101	Q96C45
MESSLVASELPLLIE	KMT2D	3236	O14686
LMLLRLSEPAELTDA	KLK3	121	P07288
LLAENLLSPEDMVLF	LDLR	641	P01130
MEAPAELLAALPALA	MXRA7	1	P84157
ALDDPLAGLLDMLES	EXD3	51	Q8N9H8