Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

LRRC8E LRRC8C GABRP ABCC4 SLC38A10 CLCN4 KCNF1 SLC38A9 SLC35E2A KCNJ6 SLC22A2 SLC2A14 KCNN1 LRRC8A SV2C KCNS2 ABCC2 SLC35E2B MFSD4B ATP10D SLC12A5

2.80e-0912897221GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

LRRC8E LRRC8C GABRP ABCC4 SLC38A10 CLCN4 KCNF1 SLC38A9 SLC35E2A KCNJ6 SLC22A2 SLC2A14 KCNN1 LRRC8A SV2C KCNS2 ABCC2 SLC35E2B MFSD4B SLC12A5

3.76e-0911807220GO:0022857
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

VN1R3 GABRP OR13C9 GPR50 OR56B1 PTPRK OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 KIR2DS1 OPN1SW KIR3DL2 PTGER3 OR4K3 KIT LPAR1

9.99e-0713537218GO:0004888
GeneOntologyMolecularFunctionvolume-sensitive anion channel activity

LRRC8E LRRC8C LRRC8A

3.72e-069723GO:0005225
GeneOntologyMolecularFunctionG protein-coupled receptor activity

VN1R3 OR13C9 GPR50 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW PTGER3 OR4K3 LPAR1

1.44e-058847213GO:0004930
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

LRRC8E LRRC8C GABRP CLCN4 LRRC8A SLC12A5

1.75e-05151726GO:0008509
GeneOntologyMolecularFunctionchannel activity

LRRC8E LRRC8C GABRP CLCN4 KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2 SLC12A5

1.80e-055257210GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

LRRC8E LRRC8C GABRP CLCN4 KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2 SLC12A5

1.83e-055267210GO:0022803
GeneOntologyMolecularFunctionmonoatomic anion channel activity

LRRC8E LRRC8C GABRP CLCN4 LRRC8A

3.52e-05103725GO:0005253
GeneOntologyMolecularFunctionmonoatomic ion channel activity

LRRC8E LRRC8C GABRP CLCN4 KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2

3.91e-05459729GO:0005216
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCC4 SLC38A10 SLC38A9 SLC22A2 SLC2A14 LRRC8A ABCC2

8.89e-05293727GO:0008514
GeneOntologyMolecularFunctionguanine nucleotide transmembrane transporter activity

ABCC4 LRRC8A

1.27e-045722GO:0001409
GeneOntologyMolecularFunctionolfactory receptor activity

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

1.58e-04431728GO:0004984
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCC4 SLC22A2 ABCC2

2.48e-0434723GO:0042910
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCC4 CLCN4 SLC35E2A SLC22A2 ABCC2 SLC35E2B MFSD4B SLC12A5

3.14e-04477728GO:0022804
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNF1 KCNJ6 KCNN1 KCNS2 SLC12A5

3.43e-04167725GO:0015079
GeneOntologyMolecularFunctionABC-type glutathione S-conjugate transporter activity

ABCC4 ABCC2

3.54e-048722GO:0015431
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GABRP ABCC4 CLCN4 ABCC2 SLC12A5

3.82e-04171725GO:0015103
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNF1 KCNJ6 KCNN1 KCNS2

5.06e-04102724GO:0005249
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CLCN4 KCNF1 KCNJ6 KCNN1 KCNS2

5.08e-04182725GO:0005244
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

LRRC8E LRRC8C GABRP CLCN4 KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2 SLC12A5

5.32e-047937210GO:0015075
GeneOntologyMolecularFunctionvoltage-gated channel activity

CLCN4 KCNF1 KCNJ6 KCNN1 KCNS2

5.34e-04184725GO:0022832
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC4 ABCC2

5.66e-0410722GO:0043225
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

ABCC4 SLC38A10 SLC38A9 SLC22A2 ABCC2

9.09e-04207725GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

ABCC4 SLC38A10 SLC38A9 SLC22A2 ABCC2

9.29e-04208725GO:0005342
GeneOntologyMolecularFunctionL-arginine transmembrane transporter activity

SLC38A9 SLC22A2

9.75e-0413722GO:0061459
GeneOntologyMolecularFunctionprostaglandin transmembrane transporter activity

ABCC4 SLC22A2

1.13e-0314722GO:0015132
GeneOntologyMolecularFunctionpotassium channel activity

KCNF1 KCNJ6 KCNN1 KCNS2

1.18e-03128724GO:0005267
GeneOntologyMolecularFunctionnucleobase-containing compound transmembrane transporter activity

ABCC4 SLC22A2 LRRC8A

1.26e-0359723GO:0015932
GeneOntologyMolecularFunctiongated channel activity

GABRP CLCN4 KCNF1 KCNJ6 KCNN1 KCNS2

1.29e-03334726GO:0022836
GeneOntologyMolecularFunctionicosanoid transmembrane transporter activity

ABCC4 SLC22A2

1.31e-0315722GO:0071714
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC4 ABCC2

1.31e-0315722GO:0008559
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

ABCC4 SLC22A2 ABCC2

1.39e-0361723GO:1901682
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCC4 SLC22A2

1.49e-0316722GO:0015562
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRP ABCC4 CLCN4 KCNF1 KCNJ6 KCNN1 KCNS2 ABCC2 SLC12A5

1.56e-03758729GO:0015318
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC38A10 SLC38A9 SLC22A2

2.16e-0371723GO:0015179
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNF1 KCNJ6 KCNN1 KCNS2

2.22e-03152724GO:0022843
GeneOntologyMolecularFunctionbasic amino acid transmembrane transporter activity

SLC38A9 SLC22A2

2.34e-0320722GO:0015174
GeneOntologyMolecularFunctionD-glucose transmembrane transporter activity

SLC2A14 MFSD4B

3.65e-0325722GO:0055056
GeneOntologyMolecularFunctionhexose transmembrane transporter activity

SLC2A14 MFSD4B

3.65e-0325722GO:0015149
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC2A14 MFSD4B

4.25e-0327722GO:0015145
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

CLCN4 SLC35E2A SLC35E2B MFSD4B SLC12A5

4.31e-03296725GO:0015291
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNJ6 KCNN1

4.56e-0328722GO:0005242
GeneOntologyMolecularFunctionpurine nucleotide transmembrane transporter activity

ABCC4 LRRC8A

4.89e-0329722GO:0015216
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC2A14 MFSD4B

4.89e-0329722GO:0051119
GeneOntologyMolecularFunctionprotein tyrosine phosphatase activity

PTPN3 PTPN4 PTPRK

6.14e-03103723GO:0004725
GeneOntologyMolecularFunctionnucleotide transmembrane transporter activity

ABCC4 LRRC8A

6.30e-0333722GO:0015215
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC38A10 SLC38A9 SLC22A2

6.48e-03105723GO:0015171
GeneOntologyMolecularFunctionvitamin transmembrane transporter activity

SLC22A2 SLC2A14

7.46e-0336722GO:0090482
GeneOntologyMolecularFunctionorganophosphate ester transmembrane transporter activity

ABCC4 LRRC8A

8.72e-0339722GO:0015605
GeneOntologyBiologicalProcessguanine nucleotide transmembrane transport

LRRC8E LRRC8C ABCC4 LRRC8A

2.66e-0810714GO:1903790
GeneOntologyBiologicalProcesscyclic nucleotide transport

LRRC8E LRRC8C ABCC4 LRRC8A

4.18e-0811714GO:0070729
GeneOntologyBiologicalProcessguanine nucleotide transport

LRRC8E LRRC8C ABCC4 LRRC8A

4.18e-0811714GO:0001408
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

LRRC8E LRRC8C GABRP ABCC4 CLCN4 LRRC8A ABCC2 SLC12A5

5.46e-08153718GO:0098656
GeneOntologyBiologicalProcessmonoatomic anion transport

LRRC8E LRRC8C GABRP ABCC4 CLCN4 LRRC8A ABCC2 SLC12A5

2.18e-07183718GO:0006820
GeneOntologyBiologicalProcesspurine-containing compound transmembrane transport

LRRC8E LRRC8C ABCC4 SLC22A2 LRRC8A

2.51e-0740715GO:0072530
GeneOntologyBiologicalProcessmonoatomic ion transport

LRRC8E LRRC8C GABRP PTPN3 ABCC4 CLCN4 KCNF1 KCNJ6 SLC22A2 KCNN1 LRRC8A KCNS2 CTNNB1 ABCC2 MFSD4B PTGER3 ATP10D SLC12A5

6.25e-0713747118GO:0006811
GeneOntologyBiologicalProcesscyclic-GMP-AMP transmembrane import across plasma membrane

LRRC8E LRRC8C LRRC8A

2.16e-068713GO:0140361
GeneOntologyBiologicalProcessamino acid transmembrane transport

LRRC8E LRRC8C SLC38A10 SLC38A9 SLC22A2 LRRC8A

3.60e-06120716GO:0003333
GeneOntologyBiologicalProcessnucleotide transmembrane transport

LRRC8E LRRC8C ABCC4 LRRC8A

3.78e-0631714GO:1901679
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

LRRC8E LRRC8C GABRP PTPN3 ABCC4 CLCN4 KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2 ABCC2 PTGER3 ATP10D SLC12A5

4.71e-0611157115GO:0034220
GeneOntologyBiologicalProcessorganic anion transport

LRRC8E LRRC8C ABCC4 SLC38A10 SLC38A9 SLC22A2 SLC2A14 LRRC8A ABCC2 PTGER3

1.02e-055157110GO:0015711
GeneOntologyBiologicalProcesspurine ribonucleotide transport

LRRC8E LRRC8C ABCC4 LRRC8A

1.07e-0540714GO:0015868
GeneOntologyBiologicalProcessregulation of colon smooth muscle contraction

PTGER3 KIT

1.17e-052712GO:1904341
GeneOntologyBiologicalProcesspositive regulation of colon smooth muscle contraction

PTGER3 KIT

1.17e-052712GO:1904343
GeneOntologyBiologicalProcesscolon smooth muscle contraction

PTGER3 KIT

1.17e-052712GO:1990765
GeneOntologyBiologicalProcessadenine nucleotide transport

LRRC8E LRRC8C ABCC4 LRRC8A

1.31e-0542714GO:0051503
GeneOntologyBiologicalProcesspurine nucleotide transport

LRRC8E LRRC8C ABCC4 LRRC8A

1.58e-0544714GO:0015865
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

LRRC8E LRRC8C SLC38A10 SLC38A9 SLC22A2 LRRC8A

2.08e-05163716GO:1905039
GeneOntologyBiologicalProcessorganic acid transmembrane transport

LRRC8E LRRC8C SLC38A10 SLC38A9 SLC22A2 LRRC8A

2.39e-05167716GO:1903825
GeneOntologyBiologicalProcessnucleotide transport

LRRC8E LRRC8C ABCC4 LRRC8A

2.63e-0550714GO:0006862
GeneOntologyBiologicalProcessdetection of stimulus

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 CTNNB1 OPN1SW OR4K3 KIT

3.39e-057227111GO:0051606
GeneOntologyBiologicalProcessamino acid transport

LRRC8E LRRC8C SLC38A10 SLC38A9 SLC22A2 LRRC8A

5.68e-05195716GO:0006865
GeneOntologyBiologicalProcessaspartate transmembrane transport

LRRC8E LRRC8C LRRC8A

5.74e-0522713GO:0015810
GeneOntologyBiologicalProcessxenobiotic transport

ABCC4 SLC22A2 ABCC2 CLDN1

7.01e-0564714GO:0042908
GeneOntologyBiologicalProcesssulfur compound transport

LRRC8C ABCC4 SLC22A2 LRRC8A

7.45e-0565714GO:0072348
GeneOntologyBiologicalProcesscarboxylic acid transport

LRRC8E LRRC8C ABCC4 SLC38A10 SLC38A9 SLC22A2 LRRC8A ABCC2

8.11e-05410718GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

LRRC8E LRRC8C ABCC4 SLC38A10 SLC38A9 SLC22A2 LRRC8A ABCC2

8.39e-05412718GO:0015849
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

VN1R3 OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

1.05e-04547719GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

1.16e-04432718GO:0050911
GeneOntologyBiologicalProcessC4-dicarboxylate transport

LRRC8E LRRC8C LRRC8A

1.34e-0429713GO:0015740
GeneOntologyBiologicalProcessimport across plasma membrane

LRRC8E LRRC8C KCNJ6 SLC22A2 LRRC8A SLC12A5

1.41e-04230716GO:0098739
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

KCNF1 KCNJ6 KCNN1 KCNS2 PTGER3 SLC12A5

1.48e-04232716GO:0071805
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3 KIT

1.67e-04582719GO:0050906
GeneOntologyBiologicalProcessxenobiotic transport across blood-brain barrier

SLC22A2 ABCC2

1.74e-046712GO:1990962
GeneOntologyBiologicalProcesssensory perception of smell

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

1.93e-04465718GO:0007608
GeneOntologyBiologicalProcessprostaglandin transport

ABCC4 SLC22A2 ABCC2

2.17e-0434713GO:0015732
GeneOntologyBiologicalProcessorganophosphate ester transport

LRRC8E LRRC8C ABCC4 LRRC8A ATP10D

2.41e-04162715GO:0015748
GeneOntologyBiologicalProcesspositive regulation of gastro-intestinal system smooth muscle contraction

PTGER3 KIT

2.43e-047712GO:1904306
GeneOntologyBiologicalProcessleukotriene transport

ABCC4 ABCC2

2.43e-047712GO:0071716
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

2.56e-04485718GO:0050907
GeneOntologyBiologicalProcesssensory perception

VN1R3 OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 CLDN19 OPN1SW OR4K3 KIT

2.73e-0410727112GO:0007600
GeneOntologyBiologicalProcessalkanesulfonate transmembrane transport

LRRC8C LRRC8A

3.23e-048712GO:0042918
GeneOntologyBiologicalProcesstaurine transmembrane transport

LRRC8C LRRC8A

3.23e-048712GO:0015734
GeneOntologyBiologicalProcesscarbohydrate derivative transport

LRRC8E LRRC8C ABCC4 LRRC8A

3.37e-0496714GO:1901264
GeneOntologyBiologicalProcesspotassium ion transport

KCNF1 KCNJ6 KCNN1 KCNS2 PTGER3 SLC12A5

3.48e-04272716GO:0006813
GeneOntologyBiologicalProcesscell volume homeostasis

LRRC8E LRRC8A SLC12A5

4.08e-0442713GO:0006884
GeneOntologyBiologicalProcessregulation of gastro-intestinal system smooth muscle contraction

PTGER3 KIT

4.14e-049712GO:1904304
GeneOntologyBiologicalProcessprotein hexamerization

LRRC8C LRRC8A

4.14e-049712GO:0034214
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

4.30e-04524718GO:0009593
GeneOntologyBiologicalProcessintestine smooth muscle contraction

PTGER3 KIT

5.16e-0410712GO:0014827
GeneOntologyBiologicalProcessmonoatomic cation transport

PTPN3 KCNF1 KCNJ6 SLC22A2 KCNN1 KCNS2 CTNNB1 ABCC2 MFSD4B PTGER3 ATP10D SLC12A5

5.44e-0411577112GO:0006812
GeneOntologyBiologicalProcessprotein complex oligomerization

LRRC8C KCNF1 MAT1A LRRC8A KCNS2 CLDN1

5.44e-04296716GO:0051259
GeneOntologyBiologicalProcesschloride transmembrane transport

GABRP CLCN4 LRRC8A SLC12A5

6.05e-04112714GO:1902476
GeneOntologyBiologicalProcessresponse to osmotic stress

LRRC8E LRRC8C LRRC8A SLC12A5

6.26e-04113714GO:0006970
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

GABRP PTPN3 CLCN4 KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2 ABCC2 PTGER3 SLC12A5

6.72e-0410177111GO:0098660
GeneOntologyBiologicalProcessdicarboxylic acid transport

LRRC8E LRRC8C LRRC8A ABCC2

7.84e-04120714GO:0006835
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

VN1R3 OR13C9 GPR50 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW PTGER3 OR4K3 LPAR1

8.54e-0413957113GO:0007186
GeneOntologyBiologicalProcesschloride transport

GABRP CLCN4 LRRC8A SLC12A5

9.97e-04128714GO:0006821
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

GABRP CLCN4 LRRC8A SLC12A5

1.18e-03134714GO:0098661
GeneOntologyBiologicalProcessL-arginine transmembrane transport

SLC38A9 SLC22A2

1.19e-0315712GO:1903826
GeneOntologyBiologicalProcessgastro-intestinal system smooth muscle contraction

PTGER3 KIT

1.19e-0315712GO:0014831
GeneOntologyBiologicalProcessnegative regulation of insulin secretion

KCNJ6 HMGCR PTGER3

1.28e-0362713GO:0046676
GeneOntologyBiologicalProcessintracellular chloride ion homeostasis

ABCC2 SLC12A5

1.36e-0316712GO:0030644
GeneOntologyBiologicalProcessintracellular monoatomic anion homeostasis

ABCC2 SLC12A5

1.54e-0317712GO:0030002
GeneOntologyCellularComponentmonoatomic ion channel complex

LRRC8E LRRC8C GABRP KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2

4.63e-05378728GO:0034702
GeneOntologyCellularComponenttransporter complex

LRRC8E LRRC8C GABRP KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2 ATP10D

1.10e-04550729GO:1990351
GeneOntologyCellularComponentapical plasma membrane

GABRP ABCC4 SLC22A2 NOX4 CTNNB1 ABCC2 MFSD4B CLDN1

2.65e-04487728GO:0016324
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNF1 KCNJ6 KCNN1 KCNS2

2.76e-0491724GO:0008076
GeneOntologyCellularComponenttransmembrane transporter complex

LRRC8E LRRC8C GABRP KCNF1 KCNJ6 KCNN1 LRRC8A KCNS2

4.27e-04523728GO:1902495
GeneOntologyCellularComponentpotassium channel complex

KCNF1 KCNJ6 KCNN1 KCNS2

4.59e-04104724GO:0034705
GeneOntologyCellularComponentcell-cell junction

LIM2 PTPRK CD53 CLDN19 CTNNB1 ABCC2 KIT CLDN1

9.50e-04591728GO:0005911
GeneOntologyCellularComponentapical part of cell

GABRP ABCC4 SLC22A2 NOX4 CTNNB1 ABCC2 MFSD4B CLDN1

9.60e-04592728GO:0045177
GeneOntologyCellularComponentbicellular tight junction

LIM2 CLDN19 CTNNB1 CLDN1

1.09e-03131724GO:0005923
GeneOntologyCellularComponenttight junction

LIM2 CLDN19 CTNNB1 CLDN1

1.36e-03139724GO:0070160
GeneOntologyCellularComponentapical junction complex

LIM2 CLDN19 CTNNB1 CLDN1

2.17e-03158724GO:0043296
DomainLRRC8_Pannexin-like

LRRC8E LRRC8C LRRC8A

4.59e-075683IPR021040
DomainPannexin_like

LRRC8E LRRC8C LRRC8A

4.59e-075683PF12534
DomainG_PROTEIN_RECEP_F1_1

VN1R3 OR13C9 GPR50 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW PTGER3 LPAR1

5.96e-066856812PS00237
DomainG_PROTEIN_RECEP_F1_2

VN1R3 OR13C9 GPR50 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW PTGER3 LPAR1

6.51e-066916812PS50262
DomainGPCR_Rhodpsn

VN1R3 OR13C9 GPR50 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW PTGER3 LPAR1

6.60e-066926812IPR000276
DomainTyr_Pase_non-rcpt_typ-3/4

PTPN3 PTPN4

1.31e-052682IPR012151
DomainGPCR_Rhodpsn_7TM

OR13C9 GPR50 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW PTGER3 LPAR1

2.78e-056706811IPR017452
Domain7tm_1

OR13C9 GPR50 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW PTGER3 LPAR1

3.06e-056776811PF00001
DomainSugar_transporter_CS

SLC22A2 SLC2A14 SV2C

2.12e-0432683IPR005829
DomainK_chnl_volt-dep_Kv9

KCNF1 KCNS2

2.71e-047682IPR003971
DomainMFS_sugar_transport-like

SLC22A2 SLC2A14 SV2C

3.02e-0436683IPR005828
DomainSugar_tr

SLC22A2 SLC2A14 SV2C

3.02e-0436683PF00083
DomainPTPc

PTPN3 PTPN4 PTPRK

3.02e-0436683SM00194
DomainTYR_PHOSPHATASE_PTP

PTPN3 PTPN4 PTPRK

3.84e-0439683PS50055
DomainPMP22_Claudin

LIM2 CLDN19 CLDN1

4.14e-0440683PF00822
DomainPTPase_domain

PTPN3 PTPN4 PTPRK

4.46e-0441683IPR000242
DomainY_phosphatase

PTPN3 PTPN4 PTPRK

4.46e-0441683PF00102
DomainOlfact_rcpt

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3

5.57e-04393687IPR000725
DomainSugar_P_trans_dom

SLC35E2A SLC35E2B

5.77e-0410682IPR004853
DomainTPT

SLC35E2A SLC35E2B

5.77e-0410682PF03151
DomainPMP22/EMP/MP20/Claudin

LIM2 CLDN19 CLDN1

5.87e-0445683IPR004031
Domainig

PTPRK IGSF1 KIR2DS1 KIR3DL2 KIT

6.41e-04190685PF00047
DomainImmunoglobulin

PTPRK IGSF1 KIR2DS1 KIR3DL2 KIT

6.41e-04190685IPR013151
DomainPTPc_motif

PTPN3 PTPN4 PTPRK

1.30e-0359683SM00404
DomainTyr_Pase_cat

PTPN3 PTPN4 PTPRK

1.30e-0359683IPR003595
DomainMFS_dom

SLC22A2 SLC2A14 SV2C MFSD4B

1.45e-03134684IPR020846
DomainSUGAR_TRANSPORT_2

SLC22A2 SLC2A14

1.71e-0317682PS00217
DomainAa_trans

SLC38A10 SLC38A9

1.71e-0317682PF01490
DomainAA_transpt_TM

SLC38A10 SLC38A9

1.71e-0317682IPR013057
DomainTyr_Pase_AS

PTPN3 PTPN4 PTPRK

2.39e-0373683IPR016130
DomainEz/rad/moesin-like

PTPN3 PTPN4

2.62e-0321682IPR000798
DomainTetraspanin_CS

TSPAN6 CD53

2.62e-0321682IPR018503
DomainClaudin_CS

CLDN19 CLDN1

2.88e-0322682IPR017974
DomainCLAUDIN

CLDN19 CLDN1

2.88e-0322682PS01346
DomainSUGAR_TRANSPORT_1

SLC22A2 SLC2A14

3.42e-0324682PS00216
DomainABC_membrane

ABCC4 ABCC2

3.42e-0324682PF00664
DomainFERM_CS

PTPN3 PTPN4

3.42e-0324682IPR019747
DomainTYR_PHOSPHATASE_1

PTPN3 PTPN4 PTPRK

3.81e-0386683PS00383
DomainTYR_PHOSPHATASE_2

PTPN3 PTPN4 PTPRK

3.93e-0387683PS50056
DomainTYR_PHOSPHATASE_dom

PTPN3 PTPN4 PTPRK

3.93e-0387683IPR000387
DomainTM4_1

TSPAN6 CD53

4.01e-0326682PS00421
DomainFERM_C

PTPN3 PTPN4

4.01e-0326682PF09380
DomainK_chnl_volt-dep_Kv

KCNF1 KCNS2

4.32e-0327682IPR003968
DomainFERM_C

PTPN3 PTPN4

4.32e-0327682SM01196
DomainFERM_PH-like_C

PTPN3 PTPN4

4.32e-0327682IPR018980
Domain-

PTPN3 PTPN4 PTPRK

4.60e-03926833.90.190.10
DomainABC_TM1F

ABCC4 ABCC2

4.64e-0328682PS50929
DomainClaudin

CLDN19 CLDN1

4.64e-0328682IPR006187
DomainABC1_TM_dom

ABCC4 ABCC2

4.64e-0328682IPR011527
DomainProt-tyrosine_phosphatase-like

PTPN3 PTPN4 PTPRK

5.64e-0399683IPR029021
DomainTetraspanin

TSPAN6 CD53

6.04e-0332682IPR000301
DomainTetraspanin_EC2

TSPAN6 CD53

6.04e-0332682IPR008952
DomainTetraspannin

TSPAN6 CD53

6.41e-0333682PF00335
DomainFERM_N

PTPN3 PTPN4

6.41e-0333682PF09379
DomainTetraspanin/Peripherin

TSPAN6 CD53

6.41e-0333682IPR018499
DomainVG_K_chnl

KCNF1 KCNS2

6.41e-0333682IPR028325
DomainFERM_N

PTPN3 PTPN4

6.41e-0333682IPR018979
DomainMFS

SLC22A2 SLC2A14 SV2C

7.18e-03108683PS50850
PathwayWP_SMALL_LIGAND_GPCRS

GPR50 PTGER3 LPAR1

5.50e-0519563M39728
PathwayWP_CHOLESTASIS

ABCC4 HMGCR ABCC2

5.50e-0519563M45520
PathwayWP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING

ABCC4 MAPK12 ABCC2

9.94e-0523563M39709
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

LRRC8E LRRC8C ABCC4 CLCN4 SLC22A2 SLC2A14 LRRC8A ABCC2 MFSD4B ATP10D SLC12A5

1.26e-047365611M27287
PathwayREACTOME_MISCELLANEOUS_TRANSPORT_AND_BINDING_EVENTS

LRRC8E LRRC8C LRRC8A

1.28e-0425563MM15172
PathwayREACTOME_MISCELLANEOUS_TRANSPORT_AND_BINDING_EVENTS

LRRC8E LRRC8C LRRC8A

1.45e-0426563M27424
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

2.24e-04417568M4072
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

LRRC8E LRRC8C ABCC4 CLCN4 SLC22A2 SLC2A14 LRRC8A ABCC2 ATP10D SLC12A5

3.07e-046815610MM14985
PathwayREACTOME_POTASSIUM_CHANNELS

KCNF1 KCNJ6 KCNN1 KCNS2

6.11e-0498564MM14545
PathwayREACTOME_POTASSIUM_CHANNELS

KCNF1 KCNJ6 KCNN1 KCNS2

7.38e-04103564M1073
PathwayREACTOME_SENSORY_PERCEPTION

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OPN1SW OR4K3

8.28e-04636569M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3

8.35e-04389567M14091
Pubmed

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

LRRC8E LRRC8C LRRC8A

3.40e-08472326824658
Pubmed

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.

LRRC8E LRRC8C LRRC8A

3.40e-08472333171122
Pubmed

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.

LRRC8E LRRC8C LRRC8A

8.48e-08572335777784
Pubmed

LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.

LRRC8E LRRC8C LRRC8A

8.48e-08572315094057
Pubmed

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

LRRC8E LRRC8C LRRC8A

8.48e-08572324790029
Pubmed

Ion channel expression in the developing enteric nervous system.

CLCN4 KCNF1 KCNJ6 KCNN1

1.06e-063772425798587
Pubmed

Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.

OR13C9 OR13C5 OR13C2

1.85e-061272312906860
Pubmed

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

LRRC8E LRRC8C LRRC8A

1.85e-061272332277911
Pubmed

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

PTPN3 PTPRK CTNNB1 KIT

2.81e-064772419167335
Pubmed

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.

PTPN4 MAPK12

4.23e-06272225158884
Pubmed

PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.

PTPN3 MAPK12

4.23e-06272220332238
Pubmed

Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation.

PTPN3 MAPK12

4.23e-06272225314968
Pubmed

KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia.

CTNNB1 KIT

4.23e-06272217949810
Pubmed

LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.

LRRC8E LRRC8A

4.23e-06272233139539
Pubmed

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

PTPN4 MAPK12

4.23e-06272227246854
Pubmed

The WNT/MYB pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation.

CTNNB1 KIT

4.23e-06272227161149
Pubmed

Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers.

CTNNB1 CLDN1

4.23e-06272211939410
Pubmed

SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.

SLC35E2A SLC35E2B

4.23e-06272235247439
Pubmed

Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

ABCC4 ABCC2

4.23e-06272217083032
Pubmed

Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin.

KANK1 CTNNB1

4.23e-06272216968744
Pubmed

Influence of ABCC2 and ABCC4 polymorphisms on tenofovir plasma concentrations in Thai HIV-infected patients.

ABCC4 ABCC2

4.23e-06272225801567
Pubmed

The expression of claudin 1 correlates with β-catenin and is a prognostic factor of poor outcome in gastric cancer.

CTNNB1 CLDN1

4.23e-06272224535143
Pubmed

Structure of a volume-regulated anion channel of the LRRC8 family.

LRRC8C LRRC8A

4.23e-06272229769723
Pubmed

Chemotherapeutic alteration of β-catenin and c-kit expression by imatinib in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro.

CTNNB1 KIT

4.23e-06272221993766
Pubmed

Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.

ABCC4 ABCC2

4.23e-06272223222202
Pubmed

p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.

PTPN3 MAPK12

4.23e-06272222730326
Pubmed

E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway.

CTNNB1 PTGER3

4.23e-06272228254818
Pubmed

Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor.

CTNNB1 PTGER3

4.23e-06272226058972
Pubmed

Structure of a volume-regulated heteromeric LRRC8A/C channel.

LRRC8C LRRC8A

4.23e-06272236522427
Pubmed

Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.

PTPN3 PTPN4 PTPRK

4.67e-06167238875997
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CLCN4 KCNF1 KCNJ6 KCNN1 KCNS2

1.07e-0513972516985003
Pubmed

Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients.

SLC22A2 ABCC2

1.27e-05372227590272
Pubmed

Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice.

ABCC4 ABCC2

1.27e-05372217273943
Pubmed

Expression of c-kit, a proto-oncogene of the murine W locus, in cerebella of normal and neurological mutant mice: immunohistochemical and in situ hybridization analysis.

KCNJ6 KIT

1.27e-0537221282111
Pubmed

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.

ABCC4 ABCC2

1.27e-05372225952649
Pubmed

Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.

ABCC4 ABCC2

1.27e-05372219480556
Pubmed

Nox2 and Nox4 influence neonatal c-kit(+) cardiac precursor cell status and differentiation.

NOX4 KIT

1.27e-05372223832701
Pubmed

The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.

PTPN3 PTPN4

1.27e-05372219107198
Pubmed

Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.

ABCC4 ABCC2

1.27e-05372217578901
Pubmed

Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells.

CTNNB1 CLDN1

1.27e-05372220937153
Pubmed

Immunohistochemical and molecular analysis of tyrosine kinase activity in desmoid tumors.

CTNNB1 KIT

1.27e-05372221195420
Pubmed

PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells.

PTPRK CTNNB1

1.27e-05372218276111
Pubmed

Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.

PTPRK CTNNB1

1.27e-0537228663237
Pubmed

Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides.

ABCC4 ABCC2

1.27e-05372217485564
Pubmed

The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cells.

PTPRK CTNNB1

1.27e-05372221690299
Pubmed

The human olfactory receptor gene family.

OR13C9 OR56B1 OR10H3 OR4C6 OR13C5 OR13C2 OR2B3 OR4K3

1.63e-0554172814983052
Pubmed

Hematopoietic stem cell development requires transient Wnt/β-catenin activity.

CTNNB1 KIT

2.53e-05472222802352
Pubmed

Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China.

CTNNB1 KIT

2.53e-05472212824925
Pubmed

Upregulated epithelial junction expression represents a novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosa.

CTNNB1 CLDN1

2.53e-05472229675597
Pubmed

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis.

CLCN4 KCNF1

2.53e-05472226546361
Pubmed

Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.

ABCC4 ABCC2

2.53e-05472218690847
Pubmed

Expression and significance of tumor drug resistance related proteins and beta-catenin in esophageal squamous cell carcinoma.

CTNNB1 ABCC2

2.53e-05472220193114
Pubmed

Mast cells are an essential hematopoietic component for polyp development.

CTNNB1 KIT

2.53e-05472218077429
Pubmed

Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin.

CTNNB1 CLDN1

2.53e-05472219184060
Pubmed

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

LRRC8E LRRC8A

2.53e-05472228193731
Pubmed

Pancreatic islet and progenitor cell surface markers with cell sorting potential.

SLC38A10 TSPAN6 CD53 KIT

3.15e-058672421947380
Pubmed

Age-induced reprogramming of mast cell degranulation.

PTGER3 KIT

4.21e-05572216237060
Pubmed

A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.

CTNNB1 KIT

4.21e-05572231685822
Pubmed

Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal.

CTNNB1 KIT

4.21e-05572221768263
Pubmed

NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.

KIT ADAM28

4.21e-05572232499443
Pubmed

Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.

ABCC4 ABCC2

4.21e-05572219400747
Pubmed

Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.

PTGER3 KIT LPAR1

4.44e-053372339002541
Pubmed

Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.

PTGER3 KIT

6.31e-05672224342806
Pubmed

Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study.

ABCC4 ABCC2

6.31e-05672216791115
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

ABCC4 SLC22A2 ABCC2 CLDN1

6.89e-0510572430280653
Pubmed

TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.

CTNNB1 KIT

8.82e-05772212060722
Pubmed

Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.

ABCC4 ABCC2

8.82e-05772220922799
Pubmed

HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability.

NOX4 CTNNB1

1.17e-04872224965120
Pubmed

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

ABCC4 ABCC2

1.17e-04872215802388
Pubmed

Human diversity in killer cell inhibitory receptor genes.

KIR2DS1 KIR3DL2

1.17e-0487229430221
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

PTPN3 ABCC4 SLC38A10 SPPL2A SLC38A9 ZDHHC6 ABCC2 MFSD4B

1.20e-0471972835337019
Pubmed

Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged.

CTNNB1 CLDN1

1.51e-04972220089884
Pubmed

Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population.

KIR2DS1 KIR3DL2

1.51e-04972218074414
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

ABCC4 SLC22A2 ABCC2

1.75e-045272326590417
Pubmed

Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.

KIR2DS1 KIR3DL2

1.88e-041072212559621
Pubmed

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.

CTNNB1 KIT

1.88e-041072226418893
Pubmed

Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse.

LIM2 KIT

2.30e-04117228812411
Pubmed

Temporal control of neural crest lineage generation by Wnt/β-catenin signaling.

CTNNB1 KIT

2.30e-041172222573620
Pubmed

Identification of potential bladder progenitor cells in the trigone.

CTNNB1 KIT

2.75e-041272224992712
Pubmed

[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.].

KIR2DS1 KIR3DL2

2.75e-041272220137308
Pubmed

Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients.

ABCC4 ABCC2

3.25e-041372219696793
Pubmed

Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.

SLC22A2 HMGCR ABCC2

3.54e-046672320679960
Pubmed

Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

KIR2DS1 KIR3DL2

3.78e-041472219875891
Pubmed

Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.

CTNNB1 KIT

3.78e-041472224036309
Pubmed

[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].

KIR2DS1 KIR3DL2

3.78e-041472219489269
Pubmed

A targeted mutation of Nkd1 impairs mouse spermatogenesis.

CTNNB1 KIT

3.78e-041472215546883
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.

KIR2DS1 KIR3DL2

3.78e-041472215896204
Pubmed

Fibroblast growth factor receptor-mediated activation of AKT-β-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells.

MAT1A CTNNB1

3.78e-041472223308088
Pubmed

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.

KIR2DS1 KIR3DL2

3.78e-041472218945962
Pubmed

Subcellular localization of intracellular protein tyrosine phosphatases in T cells.

PTPN3 PTPN4

3.78e-041472210940933
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.

KIR2DS1 KIR3DL2

4.36e-041572220082646
Pubmed

[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].

KIR2DS1 KIR3DL2

4.36e-041572220356536
Pubmed

Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.

SLC38A10 SLC38A9

4.36e-041572223506890
Pubmed

Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.

KIR2DS1 KIR3DL2

4.36e-041572219926642
Pubmed

Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.

KIR2DS1 KIR3DL2

4.36e-041572220643584
Pubmed

KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.

KIR2DS1 KIR3DL2

4.36e-041572217498266
Pubmed

Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.

KIR2DS1 KIR3DL2

4.36e-041572219326408
Pubmed

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.

HMGCR CTNNB1 CLDN1

4.96e-047472326332085
Pubmed

Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.

KIR2DS1 KIR3DL2

4.98e-041672219897003
Pubmed

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.

CTNNB1 KIT

4.98e-041672210932191
InteractionTSPAN15 interactions

LRRC8E LRRC8C YIPF5 SLC38A10 TM9SF3 TSPAN6 LRRC8A SCAMP2 LPAR1

3.18e-07276679int:TSPAN15
InteractionLPAR1 interactions

LRRC8E ABCC4 GPR50 TM9SF3 LRRC8A SCAMP2 HMGCR LPAR1

4.68e-07210678int:LPAR1
InteractionLGALS8 interactions

LRRC8E LRRC8C ABCC4 SPPL2A PTPRK SLC38A9 LRRC8A

1.78e-06174677int:LGALS8
InteractionCD63 interactions

ABCC4 YIPF5 ZDHHC6 SLC22A2 TM4SF18 KIT

2.16e-06114676int:CD63
InteractionLGALS3 interactions

LIM2 C1GALT1C1 ABCC4 PTPRK SLC38A9 CTNNB1 ABCC2 LPAR1

1.66e-05340678int:LGALS3
InteractionCLEC2D interactions

LRRC8E SLC38A10 GPR50 TM9SF3 CLDN19 TM4SF18

4.92e-05197676int:CLEC2D
InteractionOR10H2 interactions

LRRC8E LRRC8C ABCC4 LRRC8A

9.68e-0572674int:OR10H2
CytobandEnsembl 112 genes in cytogenetic band chr9q31

PTPN3 OR13C9 OR13C5 OR13C2 LPAR1

2.62e-06137725chr9q31
Cytoband1p36.33

FNDC10 SLC35E2A CFAP74 SLC35E2B

6.90e-06777241p36.33
Cytoband9q31.1

OR13C9 OR13C5 OR13C2

3.78e-05417239q31.1
Cytoband19q13.4

LIM2 KIR2DS1 KIR3DL2

2.68e-047972319q13.4
Cytoband19p13.1

OR10H3 KCNN1

2.61e-034872219p13.1
Cytoband20q13.12

WFDC11 SLC12A5

4.05e-036072220q13.12
GeneFamilyVolume regulated anion channel subunits

LRRC8E LRRC8C LRRC8A

3.12e-0755831158
GeneFamilyOlfactory receptors, family 13

OR13C9 OR13C5 OR13C2

5.30e-0523583162
GeneFamilySolute carriers

SLC38A10 SLC38A9 SLC35E2A SLC22A2 SLC2A14 SLC35E2B SLC12A5

2.59e-04395587752
GeneFamilyATP binding cassette subfamily C

ABCC4 ABCC2

7.71e-0413582807
GeneFamilyProtein tyrosine phosphatases, non-receptor type

PTPN3 PTPN4

1.50e-0318582812
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DS1 KIR3DL2

1.50e-0318582620
GeneFamilyClaudins

CLDN19 CLDN1

2.45e-0323582488
GeneFamilyCD molecules|Tetraspanins

TSPAN6 CD53

5.01e-0333582768
GeneFamilyPotassium voltage-gated channels

KCNF1 KCNS2

7.30e-0340582274
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

SLC38A10 SPPL2A PTPRK SLC35E2A TM9SF3 TSPAN6 SCAMP2 HMGCR SLC35E2B ATP10D

1.48e-057036910MM1055
CoexpressionMILI_PSEUDOPODIA_CHEMOTAXIS_DN

LRRC8C C1GALT1C1 SLC38A10 SPPL2A CLCN4 SCAMP2 HMGCR CTNNB1

2.65e-05457698M1613
CoexpressionMILI_PSEUDOPODIA_CHEMOTAXIS_DN

LRRC8C C1GALT1C1 SLC38A10 SPPL2A CLCN4 SCAMP2 HMGCR CTNNB1

3.23e-05470698MM1053
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 PTPRK SLC22A2 NOX4 ACMSD

5.32e-071897063b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAA4 MAT1A ACMSD ABCC2 CLDN1

2.70e-0613970582bf5ba69a907fbd9b4e2b2dd1dd27b8c4c75f25
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAA4 MAT1A ACMSD ABCC2 CLDN1

2.70e-06139705fc9ac09c2106e88104a52575832d71d17765eec8
ToppCellfacs-Liver-Hepatocytes-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAA4 MAT1A ACMSD ABCC2 CLDN1

2.70e-06139705fc4b39ac9a10cf0acacfebbc4295edf324d930d5
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAA4 MAT1A ACMSD ABCC2 CLDN1

2.70e-061397054ddfbc36a0560fb70594627178bff652ab1ea3e9
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)--|Striatum / BrainAtlas - Mouse McCarroll V32

GPR50 MROH7 CLDN19 OPN1SW

8.16e-0681704c9145c994abcf49e5492270b18b0580a3d771ccf
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)-|Striatum / BrainAtlas - Mouse McCarroll V32

GPR50 MROH7 CLDN19 OPN1SW

8.16e-068170434d2a2c30c749bd2ad447dfb1e43444953d9b154
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)|Striatum / BrainAtlas - Mouse McCarroll V32

GPR50 MROH7 CLDN19 OPN1SW

8.16e-0681704f84bfa55c6b9548f8829b16a145690d207a7bfc1
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

PTPN3 SLC22A2 NOX4 ACMSD ABCC2

9.51e-06180705864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

PTPN3 SLC22A2 ACMSD ABCC2 PTGER3

1.00e-051827059d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 PTPRK NOX4 CLDN1

1.11e-05186705b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

ABCC4 SLC22A2 NOX4 ACMSD ABCC2

1.14e-05187705d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

PTPN3 SLC22A2 ACMSD ABCC2 PTGER3

1.14e-05187705d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 SLC22A2 NOX4 ACMSD

1.20e-0518970528b502611829e4a24caff2562545c7db97686099
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

ABCC4 SLC22A2 NOX4 ACMSD ABCC2

1.20e-051897050be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 SLC22A2 NOX4 ABCC2

1.27e-051917053c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 SLC22A2 NOX4 ABCC2

1.27e-051917051c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN3 ABCC4 KANK1 PTPRK NOX4

1.36e-051947057002937e8903e037332a215d00fbc7c7843b33f2
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GABRP PTPRK LRRC8A ADAM28 CLDN1

1.51e-05198705270cecff42b87b7e03f09dd9f99547b287b4598c
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GABRP ABCC4 LRRC8A ADAM28 CLDN1

1.51e-0519870519d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GABRP PTPRK LRRC8A ADAM28 CLDN1

1.51e-051987058b3f4effaaccf8777cde854d5d8a765962f7312b
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GABRP PTPN3 LRRC8A ADAM28 CLDN1

1.54e-05199705f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCellSevere-Epithelial-Epithelial-|Severe / Condition, Lineage, Cell class and cell subclass

GABRP PTPN3 PTPRK TSPAN6 CLDN1

1.58e-052007058669ce08f93eefb8ac970e30cdc4b1f908023c54
ToppCellSevere-Epithelial|Severe / Condition, Lineage, Cell class and cell subclass

GABRP PTPN3 PTPRK TSPAN6 CLDN1

1.58e-052007056ead9db88568bb829d564a6d8e85f71fd765bac0
ToppCellSevere-Epithelial-Epithelial|Severe / Condition, Lineage, Cell class and cell subclass

GABRP PTPN3 PTPRK TSPAN6 CLDN1

1.58e-052007053bd1ce2793651c9badd69f011d2531183594e5f4
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SV2C ABCC2 KIT CLDN1

2.20e-05104704b5ca6e589f414e549f4990fe334d4ee54829b298
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pax5_(SN/VTA_(SNr))--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GABRP ACMSD ADAM28

7.99e-0553703ef2fa0364d7807cec2c0a45f940837cac6d22e43
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pax5_(SN/VTA_(SNr))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GABRP ACMSD ADAM28

7.99e-0553703974757404e411d7a0d762d21db07f9632a838be3
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pax5_(SN/VTA_(SNr))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GABRP ACMSD ADAM28

7.99e-0553703ad3eac1ffca39ace1ea1284441c60fe55b1a8470
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NOX4 IGSF1 KIT CLDN1

8.04e-0514570478f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Rasd1_(Presubiculum,_Col5a2+)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MAT1A ABCC2 KIR3DL2

8.45e-0554703e40294b708b06f7eee1c099fc67f53a3bb76e306
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Rasd1_(Presubiculum,_Col5a2+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MAT1A ABCC2 KIR3DL2

8.45e-0554703a1b3f38a90ca975a3e9c4dadfe3cd4e701a6cb1e
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

SLC22A2 NOX4 TM4SF18 ACMSD

9.41e-05151704e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-lymphoid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAA4 KCNJ6 EML6 ABCC2

9.65e-05152704acfafdb64bd5b0eb7371b04cfef51ed2798e9b30
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-common_lymphoid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAA4 KCNJ6 EML6 ABCC2

9.65e-051527049d6c88ceca0569dbeb12e488acec7fcb7f972f03
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ABCC4 KCNN1 KIT ADAM28

1.07e-041567040f2147abcf31a26ee5b2f4d8c5d72232612a33f0
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ABCC4 KCNN1 KIT ADAM28

1.07e-04156704cb87f12443fdc5538b856f765fcbac9406044e10
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KIR3DL2 PTGER3 KIT

1.18e-04160704174a4ab27114efcc63be36929b80680be3c35c9b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTPRK OR4C6 CD53 SV2C

1.21e-04161704ad9df577fea05d9d4924076d39e1454ddcfc5bab
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ABCC4 MAPK12 PTPRK LPAR1

1.23e-041627042d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRRC8E MROH7 LRRC8A KIT

1.23e-0416270480619a93c57fe16daf91dc571874ef9ac888953d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTPRK OR4C6 CD53 SV2C

1.26e-041637040a62ab956d30e5a055afdf59d5b29ca64782f2b6
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPN4 FNDC10 SLC35E2A KIT

1.29e-0416470474bf6080abd9191e3db8ee892fce84f1dcc4b775
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|367C / Donor, Lineage, Cell class and subclass (all cells)

LIM2 PTPN4 CD53 KIR3DL2

1.29e-041647044a834a7908d8aa643a2096c52430dad795898474
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GABRP FNDC10 MAT1A ADAM28

1.29e-041647046ea188e17895961cd112152fb111d08641cc5e45
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 TMPRSS7 PTGER3 KIT

1.32e-04165704a6c6de17fec678ad0cac3138dde3a14cc39ffd26
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CD53 SCAMP2 MFSD4B ADAM28

1.39e-04167704942134bbabe9972fae80cbc4ed4e94da52f55dc3
ToppCellControl-Epithelial_airway-Club_cells-Airway|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GABRP IGSF1 ADAM28 CLDN1

1.42e-04168704ce87981f4da2779de952c2e5d2bbcdabb265e705
ToppCellControl-Epithelial_airway-Club_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GABRP IGSF1 ADAM28 CLDN1

1.42e-04168704e85bc5398eb36b2b0773a8a7082e3ba740452165
ToppCelldroplet-Lung-nan-18m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPK12 TMPRSS7 PTGER3 CLDN1

1.45e-04169704f2e20049a17eee533d49bd5f24a51962d123d132
ToppCelldroplet-Lung-nan-18m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPK12 TMPRSS7 PTGER3 CLDN1

1.45e-041697044c6892551e9dec94fc62b3beab1e6d424639a1e9
ToppCellBasal_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

TSPAN6 MROH7 ADAM28 CLDN1

1.49e-04170704776d4224a682b6c648041827efd69794f88906f0
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD53 ABCC2 PTGER3 CLDN1

1.59e-041737048ca650542655c27516029e5bace97ff1b9dcc256
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPK12 TMPRSS7 PTGER3 CLDN1

1.59e-0417370453e97835d7a518c278e7b90a0734eb0095d6aa33
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAPK12 TMPRSS7 PTGER3 CLDN1

1.59e-04173704117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCelldroplet-Lung-LUNG-1m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPK12 TMPRSS7 PTGER3 CLDN1

1.59e-04173704889a880de5fc19d26b82cfef3067869a28ef17ca
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAPK12 TMPRSS7 PTGER3 CLDN1

1.59e-0417370401df9baeedf30e3a4891738554cdd300394dbb96
ToppCell10x5'-blood-Mast-Mast_cells|blood / Manually curated celltypes from each tissue

PTGER3 KIT ADAM28 ATP10D

1.62e-04174704a5838821bba2be790d32331ff529d466e9974268
ToppCell10x5'-blood-Mast|blood / Manually curated celltypes from each tissue

PTGER3 KIT ADAM28 ATP10D

1.62e-041747043a8a253213b207e3ff56f94a74996b8d9ad47aa1
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRK KIT ADAM28 SLC12A5

1.66e-0417570431f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KANK1 MAT1A TSPAN6 TMPRSS7

1.66e-04175704f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KANK1 MAT1A TSPAN6 TMPRSS7

1.66e-041757047bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCellfacs-Skin-Telogen-3m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD53 KIR3DL2 PTGER3 KIT

1.70e-041767043d372c1d527fcc118d1e5809f2524fc387682472
ToppCellfacs-Skin-Telogen-3m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD53 KIR3DL2 PTGER3 KIT

1.70e-041767047b3f3d9b33770edf294cee0eccaf8a46f9331461
ToppCellfacs-Skin-Telogen-3m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD53 KIR3DL2 PTGER3 KIT

1.70e-041767049c0fb2c6ae84febdf7c3d4e648985f597dcffe7a
ToppCellfacs-Skin-Anagen-3m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC8C CD53 KIR3DL2 PTGER3

1.73e-041777047853430fb0d1a18d835e8956777e0616c5d7d412
ToppCellfacs-Skin-Anagen-3m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC8C CD53 KIR3DL2 PTGER3

1.73e-04177704395f005f019aabb18738d3a10a04c37f216deda3
ToppCellfacs-Skin-Anagen-3m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC8C CD53 KIR3DL2 PTGER3

1.73e-041777049a5bf67a801826d094f679dd2189b62296c9694f
ToppCellICU-NoSEP-Myeloid-cDC1|ICU-NoSEP / Disease, Lineage and Cell Type

CLCN4 TSPAN6 KIT ADAM28

1.73e-0417770433cd2c183ee8b597012efcbcae72131ac6beaf4e
ToppCelldroplet-Tongue-nan-24m-Myeloid-basal_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIM2 CD53 SV2C KIR3DL2

1.77e-041787049423e209de94d26e96117581c95dc069850225d3
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC22A2 NOX4 ACMSD ABCC2

1.77e-0417870423a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC22A2 NOX4 ACMSD ABCC2

1.85e-04180704358923e4228035a3e90e2957392089219e90dcd7
ToppCell10x5'-bone_marrow-Mast-Mast_cell_lympho|bone_marrow / Manually curated celltypes from each tissue

SLC35E2A PTGER3 KIT ATP10D

1.89e-0418170456fa77ae31f3b7de6e441a439c33a11353b6573a
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC22A2 NOX4 ACMSD ABCC2

1.89e-041817046980ea624151da32b7f537f263e40fcb87a02e81
ToppCellIPF-Myeloid-DC_Langerhans|World / Disease state, Lineage and Cell class

ABCC4 PTGER3 ADAM28 CLDN1

1.93e-041827040e8cfbd8ea196f27a227dbb4d2eb93bc48d27922
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC8E GABRP CLDN19 PTGER3

1.93e-04182704b8be66a867ea1bbae0820b26dbd55b68611f5ad5
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC8E GABRP CLDN19 PTGER3

1.93e-04182704cb488f9a9b200e2557335ccf22535cd247512cdc
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

KCNS2 PTGER3 KIT ATP10D

2.01e-0418470467164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

SLC22A2 NOX4 ACMSD ABCC2

2.01e-04184704dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellIPF-Myeloid-DC_Langerhans|IPF / Disease state, Lineage and Cell class

ABCC4 PTGER3 ADAM28 CLDN1

2.05e-04185704f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KANK1 PTPRK SLC2A14 ABCC2

2.05e-041857041d874608aa2062024323512f68889219471b2f00
ToppCellIPF-Myeloid-DC_Langerhans|Myeloid / Disease state, Lineage and Cell class

ABCC4 PTGER3 ADAM28 CLDN1

2.05e-04185704ced17f69486591c3cbbdc852a3e82c3f3a4a30d7
ToppCellCOVID-19-kidney-Mito-rich_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC22A2 NOX4 ACMSD ABCC2

2.05e-041857041bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRP CFAP74 CLDN19 PTGER3

2.10e-041867048eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 SLC22A2 NOX4

2.14e-041877049d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellCOVID-19-kidney-Mito-rich_PCT|kidney / Disease (COVID-19 only), tissue and cell type

SLC22A2 NOX4 ACMSD ABCC2

2.14e-04187704738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

SLC22A2 NOX4 ACMSD ABCC2

2.14e-04187704acd305475f3609800af0d7bc68d83ef41228080b
ToppCellCOPD-Myeloid-DC_Mature|COPD / Disease state, Lineage and Cell class

ABCC4 KCNN1 KIT LPAR1

2.18e-04188704de93ccb53edb8599da9e312db0e3af604c21f673
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC22A2 NOX4 ACMSD ABCC2

2.18e-04188704f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCellNS-critical-d_07-13-Epithelial-IRC-IFNG_responsive_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SAA4 LRRC8A PTGER3 CLDN1

2.18e-041887046ee2e7fa80f48e4a7f3321b0776a4f697469bc61
ToppCell15-Distal-RBC|Distal / Age, Tissue, Lineage and Cell class

SAA4 MAT1A SLC2A14 CLDN1

2.18e-04188704c68ccb1c5c21d13ddac09b16e7d466f0530bbda5
ToppCell15-Distal-RBC-RBC|Distal / Age, Tissue, Lineage and Cell class

SAA4 MAT1A SLC2A14 CLDN1

2.18e-041887042534684e4932c1255c24a26ca2277ac7af0a118b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC22A2 NOX4 ACMSD ABCC2

2.18e-041887040792432cd4c564dea1102241ea9884f7ced7658c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC22A2 NOX4 ACMSD ABCC2

2.23e-04189704204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 EML6 CLDN1

2.23e-04189704904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC22A2 NOX4 ACMSD ABCC2

2.23e-0418970413fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

PTPN3 KANK1 PTPRK CLDN1

2.27e-04190704ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PTPN3 ABCC4 KANK1 PTPRK

2.32e-0419170434cc997e4e5c727495f321e6807a84aa124da486
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 KANK1 EML6 CLDN1

2.32e-04191704d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell368C-Myeloid-Dendritic-cDC2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRRC8C PTGER3 ADAM28 CLDN1

2.32e-0419170485dba3a8a52307df52d1d78a6f278501298f3067
Drug0-to

PTPN3 MAPK12 NOX4 HMGCR PTGER3 LPAR1

4.80e-06141706CID000002051
Diseasemetabolite measurement

ABCC4 MAPK12 SLC22A2 ACMSD ABCC2 MFSD4B ATP10D SLC12A5

3.50e-05560668EFO_0004725
Diseasecognitive inhibition measurement

HIVEP2 OR13C9 OR13C2

1.94e-0450663EFO_0007969
Diseasehepatoblastoma (is_marker_for)

CTNNB1 CLDN1

5.08e-0415662DOID:687 (is_marker_for)
Diseasetriacylglycerol 50:5 measurement

LRRC8E YIPF5

5.79e-0416662EFO_0010412
Diseasenon-alcoholic steatohepatitis (biomarker_via_orthology)

NOX4 CLDN1

6.56e-0417662DOID:0080547 (biomarker_via_orthology)
Diseaseextrahepatic cholestasis (biomarker_via_orthology)

ABCC4 SLC22A2

6.56e-0417662DOID:13619 (biomarker_via_orthology)
DiseasePseudopelade

ABCC2 CLDN1

8.22e-0419662C0086873
Diseasecumulative dose response to bevacizumab

PTPN4 SV2C

8.22e-0419662EFO_0005944
Diseaseend stage renal disease (implicated_via_orthology)

HMGCR ABCC2

9.12e-0420662DOID:783 (implicated_via_orthology)
Diseasemigraine disorder

KANK1 ZDHHC6 SV2C MFSD4B ADAM28

1.23e-03357665MONDO_0005277
DiseaseNeoplasm of the genitourinary tract

CTNNB1 KIT

1.32e-0324662cv:C0042065
DiseaseDrug-Induced Stevens Johnson Syndrome

CTNNB1 PTGER3

1.92e-0329662C1274933
DiseaseToxic Epidermal Necrolysis

CTNNB1 PTGER3

1.92e-0329662C0014518
DiseaseMycoplasma-Induced Stevens-Johnson Syndrome

CTNNB1 PTGER3

1.92e-0329662C3658301
DiseaseStevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

CTNNB1 PTGER3

1.92e-0329662C3658302
DiseaseStevens-Johnson Syndrome

CTNNB1 PTGER3

2.06e-0330662C0038325

Protein segments in the cluster

PeptideGeneStartEntry
SIIMVVAFLGCMGSI

CD53

61

P19397
LAGTTVGLAFMSTMC

ADAM28

301

Q9UKQ2
IAICSMIMGGVFEKF

ACMSD

201

Q8TDX5
GFVAMVLSVVGMKCT

CLDN19

91

Q8N6F1
GGVTRMTVSLVVIMF

CLCN4

526

P51793
MTVSLVVIMFELTGG

CLCN4

531

P51793
GVMLGSIFCALITML

C1GALT1C1

11

Q96EU7
VMLLVIMCLTGAVGH

ATP10D

326

Q9P241
FIGSLVPCMESIMTE

MROH7

1221

Q68CQ1
IGRTGVLVTMETAMC

PTPN3

846

P26045
IGRTGVLITMETAMC

PTPN4

856

P29074
MSLTVVSMACVGFFL

KIR3DL2

1

P43630
ISIVMLMIAVFGGTL

LRRC8A

31

Q8IWT6
MMVCQVGGIEALVRT

CTNNB1

436

P35222
TITIFGNVSIMMVCI

OR2B3

36

O76000
SALCAISGIIMGIMA

LIM2

71

P55344
SCMGVLLVSMVVLFI

GRINA

281

Q7Z429
LIGFVIVAGMMCIIV

KIT

526

P10721
VILEGMVEATGMTCQ

KCNJ6

306

P48051
IVCGTVMAGELSLMA

HMGCR

841

P04035
LIFGMFGIVVMVTET

KCNN1

111

Q92952
MFCAMVITIVVDLIG

GPR50

31

Q13585
LVMGLGITVCIFIML

LPAR1

51

Q92633
GVFMISTSGMIALVC

OR4K3

196

Q96R72
ITTETAIQLMGIMCV

PTGER3

276

P43115
ILSILVVMGSIITMC

KCNS2

191

Q9ULS6
FLGILCMVDMGLATT

OR56B1

71

Q8NGI3
CGVSVTEAMLGVMTE

KANK1

436

Q14678
CLMLLILVGVMGTTA

LMLN2

741

A0A1B0GTW7
KTGMVLLCGEITSMA

MAT1A

61

Q00266
FLGIISTLVMICMAT

ABCC2

1106

Q92887
STLVMICMATPVFTI

ABCC2

1111

Q92887
LTVAMLMIGVFGCTL

LRRC8E

31

Q6NSJ5
MFLSLAMGTTECVLL

OR13C5

101

Q8NGS8
AMGTTECVLLGVMAF

OR13C5

106

Q8NGS8
MFLGLAMGTTECVLL

OR13C2

101

Q8NGS9
IGLGGMAFCSTLMTV

SLC2A14

361

Q8TDB8
ILLTVMMSIFGVSIG

MFSD4B

86

Q5TF39
GLTGVCMVVVLFLMI

NOX4

161

Q9NPH5
GSKTSSVIMGVMLVC

OR10H3

191

O60404
MEIGISCLAGMAVLI

ABCC4

231

O15439
FTVLLFCIRMSLGMT

IGSF1

16

Q8N6C5
GVIAIFVATVGMKCM

CLDN1

91

O95832
AMTAVGGSICVMLVV

FNDC10

186

F2Z333
TFGSVGKLETMMCVS

EML6

856

Q6ZMW3
MRLFTGIVFCSLVMG

SAA4

1

P35542
SCLGRMGITMAYEIV

SLC22A2

436

O15244
GFTTGMCVIILMGLL

SLC38A9

146

Q8NBW4
ETSMIGLMLGTCIAF

SLC38A10

86

Q9HBR0
TLTLMGTGVASMITC

CFAP74

1331

Q9C0B2
SMITCSIEGSVLNMG

CFAP74

1341

Q9C0B2
CIGVTTVLSMTTLMI

GABRP

276

O00591
GRSGMFCAIGIVVEM

PTPRK

1381

Q15262
VVGIAGIMESFCMVF

SLC12A5

146

Q9H2X9
MSLTVVSMACVGFFL

KIR2DS1

1

Q14954
MFLGLAMGTTECVLL

OR13C9

101

Q8NGT0
EVSRMVVVMVGSFCV

OPN1SW

246

P03999
SGMMCVAIFLILIAS

OR4C6

201

Q8NH72
KVFGCSIVMVMGITD

CARS2

106

Q9HA77
TMLGGSMVLSGISCF

SV2C

611

Q496J9
MLGAVQMLSTTVIGC

SLC35E2A

106

P0CK97
ISVIMMVVAGFFTLC

SCAMP2

261

O15127
IALGVIAICSTMAMI

ZDHHC6

26

Q9H6R6
YGIITSRMLCAGIMS

TMPRSS7

766

Q7RTY8
EGICFSGIMMLIVTT

TM4SF18

51

Q96CE8
SVMSVCLMPVSILGF

SPPL2A

396

Q8TCT8
GCFIKVMTIIESEMG

TSPAN6

196

O43657
MLGAVQMLSTTVIGC

SLC35E2B

106

P0CK96
LLNLMSMTGVSFGCV

YIPF5

166

Q969M3
MAVFSTALGIMCGAI

TM9SF3

556

Q9HD45
SMGLCVLGIIVMAST

TMEM42

66

Q69YG0
VLCLGLMTLASGSMV

VN1R3

191

Q9BXE9
MICSSIVSTPVGIMA

HIVEP2

711

P31629
MLMTFFCTVLLSVLG

WFDC11

11

Q8NEX6
LILVSSVVMCMGTIP

KCNF1

191

Q9H3M0
SVGCIMAEMITGKTL

MAPK12

211

P53778
LSVAMLMIGVFGCTL

LRRC8C

31

Q8TDW0