Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainAP3_beta

AP3B1 AP3B2

3.07e-0521042IPR026740
DomainAP3B_C

AP3B1 AP3B2

3.07e-0521042IPR029390
DomainAP3B1_C

AP3B1 AP3B2

3.07e-0521042PF14796
DomainAP3B1_C

AP3B1 AP3B2

3.07e-0521042SM01355
DomainTIR

IL18R1 TLR3 IL1R1

2.07e-04211043SM00255
DomainTIR

IL18R1 TLR3 IL1R1

2.39e-04221043PF01582
Domain-

IL18R1 TLR3 IL1R1

2.74e-042310433.40.50.10140
DomainAP_beta

AP3B1 AP3B2

3.04e-0451042IPR026739
DomainTIR

IL18R1 TLR3 IL1R1

3.12e-04241043PS50104
DomainTIR_dom

IL18R1 TLR3 IL1R1

3.53e-04251043IPR000157
DomainIL-1_rcpt_I/II-typ

IL18R1 IL1R1

4.54e-0461042IPR004074
Pubmed

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis.

CASP5 IL18R1 IL1R1

5.95e-076109331076358
Pubmed

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.

CASP5 IL18R1 IL1R1

2.48e-069109330170814
Pubmed

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.

IL18R1 TLR3 IL1R1

3.54e-0610109317992263
Pubmed

Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.

ELP1 IL18R1 JAK2 TLR3 IL1R1 MUC7 ALOX5

3.87e-06204109720503287
Pubmed

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.

ELP1 IL18R1 JAK2 TLR3 IL1R1 MUC7 ALOX5

4.00e-06205109719258923
Pubmed

Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.

ELP1 IL18R1 JAK2 TLR3 IL1R1 MUC7 ALOX5

4.26e-06207109717703412
Pubmed

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.

IL18R1 TLR3 IL1R1

4.85e-0611109317572686
Pubmed

Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.

CASP5 TLR3 IL1R1

8.37e-0613109328504245
Pubmed

Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.

HOXA2 HOXB2

9.73e-062109228052248
Pubmed

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells.

IL18R1 IL1R1

9.73e-062109230093707
Pubmed

Cutting Edge: IL-1R1 Mediates Host Resistance to Mycobacterium tuberculosis by Trans-Protection of Infected Cells.

PTPRC IL1R1

9.73e-062109230068597
Pubmed

Structure and function of Semaphorin-5A glycosaminoglycan interactions.

SEMA5A PLXNA2

9.73e-062109238548715
Pubmed

IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model.

IL18R1 IL1R1

9.73e-062109236766797
Pubmed

Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-beta deposition in N2a cells.

MYH10 APP

9.73e-062109217727819
Pubmed

Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.

APP RYR2

9.73e-062109232966798
Pubmed

Replication study of RAD54B and GREB1 polymorphisms and risk of PCOS in Han Chinese.

RAD54B GREB1

9.73e-062109223876972
Pubmed

Protein kinase C-dependent alpha-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B.

MYH10 APP

9.73e-062109219103644
Pubmed

JAK2 and PTPRC mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

JAK2 PTPRC

9.73e-062109231760539
Pubmed

MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.

IL18R1 TLR3 IL1R1

1.06e-0514109316886064
Pubmed

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

IL18R1 TLR3 IL1R1

2.36e-0518109322541070
Pubmed

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

PIWIL2 DNMT3L

2.91e-053109218922463
Pubmed

IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model.

IL18R1 IL1R1

2.91e-053109236758176
Pubmed

The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.

AP3B1 AP3B2

2.91e-053109210930456
Pubmed

Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera.

JAK2 PROC

2.91e-053109218768782
Pubmed

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.

APP RYR2

2.91e-053109228476886
Pubmed

Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.

APP ALOX5

2.91e-053109223951061
Pubmed

The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.

IL18R1 IL1R1

2.91e-053109224842757
Pubmed

Arthritogenic properties of double-stranded (viral) RNA.

TLR3 IL1R1

2.91e-053109215100310
Pubmed

Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.

HOXA2 HOXB2

2.91e-053109217676642
Pubmed

Role for MyD88 signaling in murine gammaherpesvirus 68 latency.

TLR3 IL1R1

2.91e-053109218256152
Pubmed

Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes.

TLR3 IL1R1

2.91e-053109228659487
Pubmed

Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms.

JAK2 PTPRC

2.91e-053109235365653
Pubmed

Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.

APP DNMT3L

2.91e-053109226911678
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

FLII APP HOXA2 HOXB2 LRPPRC NFRKB ZMYM1 SEC23A

3.81e-05398109835016035
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

CASP5 APP IL18R1 TLR3 NFRKB HRH4 ADGRE5 SPARCL1 C8A IL1R1 EPHX4

5.76e-058241091120237496
Pubmed

Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.

APP IL18R1

5.82e-054109230127003
Pubmed

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.

PIWIL2 DNMT3L

5.82e-054109218381894
Pubmed

Regulation of large dense-core vesicle volume and neurotransmitter content mediated by adaptor protein 3.

AP3B1 AP3B2

5.82e-054109216788073
Pubmed

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.

JAK2 PTPRC

5.82e-054109211201744
Pubmed

Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus.

IL18R1 IL1R1

5.82e-054109228895072
Pubmed

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.

IL18R1 IL1R1

5.82e-054109226367276
Pubmed

Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ.

CASP5 IL18R1

5.82e-054109225367751
Pubmed

Increased Δ5- and Δ6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis.

FADS2 ALOX5

5.82e-054109221605700
Pubmed

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

IL18R1 IL1R1

5.82e-054109210653850
Pubmed

Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1-42 and Enhances Aβ1-42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death.

CASP5 APP

5.82e-054109230402707
Pubmed

The Leukotriene B4 and its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita.

PTPRC ALOX5

5.82e-054109228108297
Pubmed

Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.

IL18R1 IL1R1

5.82e-054109228895840
Pubmed

IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection.

IL18R1 IL1R1

5.82e-054109217617611
Pubmed

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

IL18R1 IL1R1

5.82e-054109224439266
Pubmed

Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.

FLII CASP5

5.82e-054109218411310
Pubmed

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.

AP3B1 LRPPRC PI4KA SNRNP200

7.97e-0572109436376293
Pubmed

Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.

LGMN APP

9.67e-055109228826672
Pubmed

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles.

CASP5 IL1R1

9.67e-055109236652908
Pubmed

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.

PIWIL2 DNMT3L

9.67e-055109227856912
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

SEMA5A PLXNA2

9.67e-055109225313870
Pubmed

Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts.

IL18R1 IL1R1

9.67e-055109235670567
Pubmed

Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.

AP3B1 AP3B2

9.67e-055109237812725
Pubmed

Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.

CASP5 IL1R1

9.67e-055109224093676
Pubmed

Association analysis between schizophrenia and the AP-3 complex genes.

AP3B1 AP3B2

9.67e-055109219481122
Pubmed

Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.

IL18R1 IL1R1

9.67e-055109229515025
Pubmed

Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.

IL18R1 IL1R1

9.67e-055109210191101
Pubmed

Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.

IL18R1 TLR3

9.67e-055109218654661
Pubmed

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.

CASP5 IL18R1

9.67e-055109237993714
Pubmed

Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion.

TLR3 IL1R1

9.67e-055109220956347
Pubmed

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

ZPBP IL18R1 JAK2 FADS2 UBAC2 IL1R1 TRIB1

1.06e-04342109723128233
Pubmed

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

APP TF

1.45e-046109218813964
Pubmed

Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.

TLR3 IL1R1

1.45e-046109218295350
Pubmed

PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.

SEMA5A PLXNA2

1.45e-046109229320740
Pubmed

Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.

AP3B1 AP3B2

1.45e-046109215537701
Pubmed

A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene.

HOXA2 HOXB2

1.45e-04610927903601
Pubmed

Protective effect of IL-18 on kainate- and IL-1 beta-induced cerebellar ataxia in mice.

IL18R1 IL1R1

1.45e-046109218250441
Pubmed

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.

CASP5 APP

1.45e-046109238326859
Pubmed

Contrasting roles of the IL-1 and IL-18 receptors in MyD88-dependent contact hypersensitivity.

IL18R1 IL1R1

1.45e-046109219657352
Pubmed

Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication.

CASP5 IL1R1

1.45e-046109231063608
Pubmed

Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.

IL18R1 IL1R1

1.45e-046109222058415
Pubmed

MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.

IL18R1 IL1R1

1.45e-046109219079579
Pubmed

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

CASP5 PHAF1 FRY NFRKB IL1R1 PRIMPOL

1.87e-04263109619773279
Pubmed

Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.

HOXA2 HOXB2

2.02e-04710928898234
Pubmed

Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.

IL18R1 IL1R1

2.02e-047109216983331
Pubmed

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.

TLR3 IL1R1

2.02e-047109225964372
Pubmed

Characterization of the adaptor-related protein complex, AP-3.

AP3B1 AP3B2

2.02e-04710929151686
Pubmed

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

CASP5 TLR3

2.02e-047109229520027
Pubmed

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure.

CASP5 IL1R1

2.02e-047109231836429
Pubmed

Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice.

PTPRC PROC

2.02e-047109210749569
Pubmed

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

TLR3 IL1R1

2.02e-047109227542117
Pubmed

Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity.

CASP5 IL1R1

2.02e-047109225198773
Pubmed

Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection.

CASP5 IL1R1

2.02e-047109226682985
Pubmed

Effects of chronically increased VEGF-A on the aging heart.

CASP5 IL1R1

2.02e-047109229146733
Pubmed

Hoxa1 and Krox-20 synergize to control the development of rhombomere 3.

HOXA2 HOXB2

2.02e-04710929806922
Pubmed

Genome-wide association study to identify genetic determinants of severe asthma.

IL18R1 IL1R1

2.02e-047109222561531
Pubmed

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.

IL18R1 IL1R1

2.02e-047109224084736
Pubmed

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.

APP TF

2.02e-047109218353773
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

GLB1L3 BCAS3 SEMA5A ADGRV1 GTDC1 RYR2 BTBD3 GREB1 SPAG16 TRIB1

2.48e-048141091023251661
Pubmed

Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules.

CASP5 IL1R1

2.69e-048109227939674
Pubmed

Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice.

TLR3 IL1R1

2.69e-048109225050810
Pubmed

Unprocessed Interleukin-36α Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1.

CASP5 IL1R1

2.69e-048109226203636
Pubmed

Association of the AP-3 adaptor complex with clathrin.

AP3B1 AP3B2

2.69e-04810929545220
Pubmed

Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant.

TLR3 IL1R1

2.69e-048109227328989
Pubmed

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism.

IL18R1 IL1R1

2.69e-048109226231118
Pubmed

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.

IL18R1 JAK2

2.69e-048109219249008
GeneFamilyOlfactory receptors, family 12

OR12D3 OR12D1

4.55e-053712160
CoexpressionGSE22601_DOUBLE_POSITIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_UP

YPEL3 RIPOR2 LIMD1 AHCYL2 PHAF1 NFRKB UBAC2

1.97e-052001087M6253
CoexpressionGSE36392_TYPE_2_MYELOID_VS_EOSINOPHIL_IL25_TREATED_LUNG_DN

YPEL3 RNF144A PIWIL2 IL18R1 JAK2 PTPRC UBAC2

1.97e-052001087M5271
CoexpressionGSE3982_EOSINOPHIL_VS_EFF_MEMORY_CD4_TCELL_UP

RIN3 RNF144A IL18R1 JAK2 HRH4 TRIB1 ALOX5

1.97e-052001087M5416
CoexpressionGSE2128_C57BL6_VS_NOD_THYMOCYTE_DN

FLII MYH10 HOXA2 PI4KA TLR3 SPARCL1 C8A

1.97e-052001087M6187
CoexpressionPARENT_MTOR_SIGNALING_UP

FLII BCAS3 PIWIL2 AP3B1 PAPSS1 TF JAK2 PI4KA CTDP1 DNAAF1 IL1R1

2.29e-0556710811M16909
CoexpressionBERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN

SFRP1 OMD TF SPARCL1

3.89e-05461084M14142
CoexpressionCOLLIS_PRKDC_SUBSTRATES

DCLRE1C CTDP1 SNRNP200

4.44e-05171083M4495
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN

LGMN MYH10 SKIDA1 TSN PAPSS1 SULF1 PI4KA SPARCL1 IL1R1

5.23e-054111089M1351
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN

LGMN MYH10 SKIDA1 TSN PAPSS1 SULF1 PI4KA SPARCL1 IL1R1

5.74e-054161089MM1002
CoexpressionGSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_2H_DN

SFRP1 ZPBP RNF144A VPS8 SEMA5A TLR3

5.78e-051621086M6084
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRV1 RYR2 SULF1 WDR17 DNAH9 UNC80 PDZRN4

1.48e-071601107c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRV1 RYR2 SULF1 WDR17 DNAH9 UNC80 PDZRN4

1.48e-07160110725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

MYH10 SEMA5A RYR2 FRY SULF1 SPARCL1 PDZRN4

4.25e-071871107464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RIN3 RIPOR2 CASP5 PTPRC ADGRE5 KYNU ALOX5

5.63e-07195110710ce1b6961f10372d1f65388cbf3626a5fcd6840
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RIN3 RIPOR2 PTPRC ADGRE5 KYNU ALOX5

4.56e-0617311060a0127bcb1d7b2b6125faef576dd843055095528
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN ADGRV1 RYR2 DNAH9 UNC80 PDZRN4

4.87e-061751106887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C11orf97 SPAG16 DNAAF1 EPHX4 DNAH9 PROC

7.12e-06187110604dba2ed09ee4180830bdf0191921696697ea234
ToppCellfacs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C11orf97 SPAG16 DNAAF1 EPHX4 DNAH9 PROC

7.12e-061871106805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RIN3 RIPOR2 PTPRC ADGRE5 KYNU ALOX5

7.34e-0618811064e27ada1bda88811b73376c8a6136cbfc83bfdb9
ToppCellFetal_29-31_weeks-Immune-monocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RIN3 IL18R1 PTPRC ADGRE5 KYNU ALOX5

7.80e-061901106ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCellCOVID-19-kidney-Myeloid|kidney / Disease (COVID-19 only), tissue and cell type

RIPOR2 IL18R1 PTPRC ADGRE5 IL1R1 ALOX5

8.28e-061921106441cd1ec171f643b28e1f6f9c04def629cc7391b
ToppCellCOVID-19-kidney-Myeloid|COVID-19 / Disease (COVID-19 only), tissue and cell type

RIPOR2 IL18R1 PTPRC ADGRE5 IL1R1 ALOX5

8.28e-0619211060b9d22a222f1201e375f8e55cace9ef939febae4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYH10 RYR2 JAK2 FRY SPARCL1 PDZRN4

8.78e-0619411065c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYH10 RYR2 JAK2 FRY SPARCL1 PDZRN4

8.78e-061941106ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RIN3 RIPOR2 PTPRC ADGRE5 KYNU ALOX5

9.04e-0619511061d58585557bf8e9ce4d514e128d3a902b526331d
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DEPTOR PAPSS1 IL18R1 FRY HRH4 ALOX5

9.04e-061951106fbedb9978ded857fd35c2a8664f7579f42edaa36
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SFRP1 SEMA5A RYR2 SULF1 FADS2 SPARCL1

9.31e-061961106525d6c8a277364e624e7cc586275f8a891436b57
ToppCellCOPD-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

SFRP1 OMD CYP4Z2P SULF1 GREB1 PDZRN4

9.31e-0619611064930eeb303d174c28fd91021723e26fdf1af9170
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYH10 RYR2 FRY SULF1 SPARCL1 PDZRN4

9.58e-061971106bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SFRP1 OMD SULF1 SPARCL1 GREB1 PDZRN4

1.01e-051991106f835e7ffe976843b0edbf695762d463da85793f3
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SFRP1 OMD SULF1 SPARCL1 GREB1 PDZRN4

1.01e-051991106993fa050a095017135a6e723c77cd38b9d782e58
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYH10 RYR2 FRY SULF1 SPARCL1 PDZRN4

1.04e-052001106a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SEMA5A TEKT5 LLGL2 TRIB1 PDZRN4

2.07e-0513411056d97fa07f55ae20c17b9d5262e893957cccc6dba
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RIPOR2 OMD SULF1 UBAC2 SPARCL1

3.56e-051501105909ccab92855f5f049dc29593aadab1ea973297b
ToppCellTracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RIN3 IL18R1 PTPRC RAD54B ADGRE5

3.67e-051511105535872e231ac0ee7b4fc4d02a260752cbbf50a2b
ToppCellfacs-Trachea-nan-24m-Myeloid-granulocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIN3 NPHS2 PTPRC HRH4 ALOX5

3.67e-05151110526fd55efb647c41436416d45952ee97b050e632c
ToppCellfacs-Marrow-KLS-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHCYL2 LLGL2 TLR3 FADS2 KYNU

4.42e-0515711055d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCellfacs-Marrow-KLS-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHCYL2 LLGL2 TLR3 FADS2 KYNU

4.42e-051571105ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCellfacs-Trachea-24m-Hematologic-myeloid-granulocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RIN3 NPHS2 PTPRC HRH4 ALOX5

4.42e-051571105188d2f85babcd4eefe20e7a392d851b2e1185bab
ToppCellfacs-Lung-nan-3m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 ZPBP IL18R1 PTPRC HRH4

4.98e-051611105ae1cee34361dde9964581cca99a29578c3b3bd99
ToppCellfacs-Lung-nan-3m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 ZPBP IL18R1 PTPRC HRH4

4.98e-05161110533de3e8b3238fcfc66dfbf89a913a07d464d6c35
ToppCelldroplet-Fat-Gat-18m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 ELP1 PTPRC TRIB1 ALOX5

5.60e-051651105c3ca2b35299294a5e3d1881fd11617e3ab720692
ToppCelldroplet-Fat-Gat-18m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 ELP1 PTPRC TRIB1 ALOX5

5.60e-051651105af32eae9324ef053f4f76e2144fb84c6e264c482
ToppCellfacs-Marrow-T_cells-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL18R1 JAK2 HRH4 ALOX5 UNC80

5.76e-051661105c22b0f3bf990d94b615a3aacee5de548da2db628
ToppCellfacs-Marrow-T_cells-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL18R1 JAK2 HRH4 ALOX5 UNC80

5.76e-0516611050975fc165bcc7e85f053d9d0244fffe407c23571
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RIPOR2 IL18R1 PTPRC ADGRE5 ALOX5

6.27e-0516911052e15a9317da4017757d184f7cc91bd66b072ac51
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Basophil|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPOR2 IL18R1 JAK2 HRH4 ALOX5

6.45e-051701105bca78719c17355772ad6c53ee75e459faf1d089f
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPOR2 IL18R1 JAK2 HRH4 ALOX5

6.45e-05170110540d863554ec98ae43f76511c1112859688846613
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

RIPOR2 PTPRC CTDP1 TRIB1 ALOX5

6.63e-0517111052b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

RIPOR2 PTPRC CTDP1 TRIB1 ALOX5

6.63e-051711105dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCelldroplet-Marrow-nan-3m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 ELP1 PTPRC TRIB1 ALOX5

6.82e-051721105cfcfa7eeff1805bedf10a3c07826459914c3e872
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RIPOR2 IL18R1 PTPRC ADGRE5 ALOX5

7.01e-0517311059eaec30f9a3655b53ece1b66848201a7f85bbdf5
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNF183 ADGRV1 BTBD3 FNDC11 AP3B2

7.20e-051741105a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PAPSS1 FRY FNDC11 HRH4 ALOX5

7.40e-051751105ba1befc4e5f0167452f9ceace39377d16136dfa9
ToppCellControl-Lymphoid-pDC|Control / Condition, Lineage and Cell class

LGMN APP IL18R1 FADS2 PROC

7.60e-0517611055de16ff65476bde8b23322a44e11412e14f1bafe
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_early_2|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

PTPRC SULF1 SPARCL1 C11orf97 DNAAF1

7.60e-0517611058e0ac3ad5e47614b4befabd674a40e3eaae553f3
ToppCell5'-Adult-LargeIntestine-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RIPOR2 IL18R1 PTPRC ADGRE5 EPHX4

8.02e-051781105a96941fef62c2f4533c557ef825ae3265f8f52db
ToppCelldroplet-Bladder-nan-24m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP1 HRH4 SPARCL1 SPAG16 UNC80

8.23e-051791105dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRRC63 RIN3 SPARCL1 PLXNA2 DNMT3L

8.45e-051801105455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

RNF144A OMD SULF1 AP3B2 FADS2

8.45e-051801105886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

MYH10 RYR2 SULF1 SPARCL1 PDZRN4

8.45e-051801105d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RIN3 RIPOR2 PTPRC ADGRE5 ALOX5

8.67e-0518111058657d35cd3dff6c89d0fde67d7e7e81e1d6c8884
ToppCellfacs-GAT-Fat-3m-Epithelial-epithelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT5 C11orf97 SPAG16 DNAH9 PROC

8.67e-051811105e97cbaafb93fdbee8e3cf4a06e6bcf121d941403
ToppCellfacs-GAT-Fat-3m-Epithelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT5 C11orf97 SPAG16 DNAH9 PROC

8.67e-05181110511cb84528f7ca084f0a92eda4f2e18e63a428fe9
ToppCellfacs-GAT-Fat-3m-Epithelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEKT5 C11orf97 SPAG16 DNAH9 PROC

8.67e-0518111055ffeca29e4d31a20c110d27af128ed024a79ad56
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

RIPOR2 PTPRC CTDP1 TRIB1 ALOX5

8.90e-051821105dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCellsevere-Myeloid-Neutrophils_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

YPEL3 RIPOR2 FRY PTPRC IL1R1

9.13e-05183110560a6112aa4fc4f5debda4c7e81b37539ba2e4e6e
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

MYH10 FRY ADGRE5 SPARCL1 PDZRN4

9.13e-051831105818fd886e0188091310825f9145fa53328f2c979
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A FRY NPHS2 SULF1 DNAH9

9.13e-0518311053c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A FRY NPHS2 SULF1 DNAH9

9.13e-0518311059c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

MYH10 FRY ADGRE5 SPARCL1 PDZRN4

9.13e-051831105cae2ee08f985a6f005b4b8e959e465350315156a
ToppCellLPS-IL1RA|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AP3B1 IL18R1 JAK2 TDRD10 PLXNA2

9.37e-051841105c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCellNS-moderate-d_07-13-Myeloid-Neutrophil|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

YPEL3 RIPOR2 CASP5 PTPRC TRIB1

9.37e-0518411054c7d05f1a4556b13cedbaaf88d67ac32d09b109b
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ANKRD31 DEPTOR FADS2 ALOX5 PROC

9.37e-0518411051c56378b3888c46258d446b47de4d6282fe74b0d
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ANKRD31 DEPTOR FADS2 ALOX5 PROC

9.37e-051841105a45980306c4e697a2703bed72a7b48fb23d942f4
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MYH10 LIMD1 DNAJC27 PHAF1 KYNU

9.86e-05186110577bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A RYR2 SULF1 WDR17 PDZRN4

9.86e-0518611054780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MYH10 LIMD1 DNAJC27 PHAF1 KYNU

9.86e-05186110513bc41c60fd628af31899a5e8b480e06cc4781be
ToppCelltumor_Lung-Epithelial_cells-tS3|Epithelial_cells / Location, Cell class and cell subclass

RIPOR2 SFRP1 C11orf97 DNAAF1 DNAH9

1.01e-0418711053cea677279e71fdb9879530dea10a5e6393beacd
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP1 HOXA2 SULF1 HRH4 SPARCL1

1.01e-0418711050f90bce2087aecfdbb377e6f46c6e468efbb6e28
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP1 HOXA2 SULF1 HRH4 SPARCL1

1.01e-04187110576c957b2976d38adb45e07bcf96c689442e1fc20
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP1 HOXA2 SULF1 HRH4 SPARCL1

1.01e-04187110590a1078b0303799fba5d2ca4fa12076fd75b78b1
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

MYH10 RYR2 FRY ADGRE5 PDZRN4

1.04e-04188110534e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellE12.5-Mesenchymal|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MYH10 SFRP1 HOXA2 HOXB2 SPARCL1

1.04e-0418811059778dadc2bd7ded3a723e717d1c8cd3160e99c6c
ToppCellControl-Myeloid-Monocytes|Control / group, cell type (main and fine annotations)

RIN3 RIPOR2 PTPRC KYNU ALOX5

1.06e-0418911053335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RYR2 JAK2 FRY SPARCL1 PDZRN4

1.06e-041891105127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

MYH10 FRY SULF1 ADGRE5 PDZRN4

1.06e-0418911056b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RYR2 JAK2 FRY SPARCL1 PDZRN4

1.06e-0418911052cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

LGMN RIN3 PTPRC KYNU ALOX5

1.06e-0418911052586f4088721c5debec86c2b211b739fd33713eb
ToppCell(1)_T_cells-(1)_T_CD4_reg|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

LGMN BCAS3 HOXB2 IL1R1 TRIB1

1.09e-041901105ff42af092173c2d4472bb9a02f5a334c272e05a0
ToppCellControl-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

OMD SULF1 SPARCL1 IL1R1 PDZRN4

1.09e-0419011054e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RIPOR2 PTPRC DNAAF1 KYNU ALOX5

1.14e-041921105d44f46352bac414b45cc749f7cbdc3a159bd7ae8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RYR2 JAK2 FRY SPARCL1 PDZRN4

1.14e-041921105bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RYR2 JAK2 FRY SPARCL1 PDZRN4

1.14e-041921105b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

CYP4Z2P C11orf97 SPAG16 DNAAF1 DNAH9

1.14e-041921105eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellNon-neuronal-Non-dividing-Radial_Glia-oRG-34|World / Primary Cells by Cluster

SFRP1 SEMA5A ADGRV1 SPARCL1 SPAG16

1.17e-041931105d55f792eb3db10452347681131e07e041348fd89
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADGRV1 SPARCL1 DNAAF1 DNAH9 PLXNA2

1.17e-041931105ea345d34440b25f65358a53dc72831998d1c3620
ToppCellcontrol-Myeloid-Neutrophils_3|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

YPEL3 RIPOR2 IL18R1 TRIB1 ALOX5

1.17e-04193110556daf3c59a124dd068af5409113913d9ee81a454
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RIPOR2 PTPRC DNAAF1 KYNU ALOX5

1.17e-041931105b044fca95f519ff2ceb378afe40a95911931a29e
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MYH10 BCAS3 RYR2 SPARCL1 PLXNA2

1.17e-0419311055896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellNon-neuronal-Non-dividing|World / Primary Cells by Cluster

SFRP1 SEMA5A ADGRV1 SPARCL1 SPAG16

1.20e-0419411050add09d97192b34bd506209ab5f1a77182f498fc
ToppCellIPF-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

SFRP1 OMD CYP4Z2P GREB1 PDZRN4

1.20e-041941105da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCellIPF-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

IL18R1 SULF1 SPARCL1 IL1R1 PDZRN4

1.20e-041941105e8a9005963704286bcc50785bda8d7d63ec001b1
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DEPTOR TF EPHX4 MUC7 UNC80

1.20e-041941105a8238f312a973cadf6eb29c1e02ba898c0a20412
ToppCellcontrol-Myeloid-Neutrophils_3|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

YPEL3 RIPOR2 IL18R1 TRIB1 ALOX5

1.20e-0419411052218e6677dc6781a6e4ef3a315f2298cc2cd9df2
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

SEMA5A RYR2 FRY SPARCL1 PDZRN4

1.20e-0419411055e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

YPEL3 ADGRV1 SULF1 DNAH9 UNC80

1.23e-041951105d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SFRP1 OMD SULF1 SPARCL1 GREB1

1.23e-041951105f54bc4454270ff06e85596f98199372b50d0179f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RIN3 IL18R1 PTPRC KYNU ALOX5

1.23e-0419511059c6bed8414633813e1655bbeaab682fb296958a9
ToppCellIPF-Stromal-Fibroblast|World / Disease state, Lineage and Cell class

SFRP1 OMD SULF1 SPARCL1 GREB1

1.23e-0419511059c32756edb54f0c211185d9a98073fe01fd1526a
Drughaloperidol; Down 200; 10uM; HL60; HT_HG-U133A

FLII JADE3 TSN AHCYL2 GTDC1 CTDP1 NFRKB FADS2 SEC23A

3.88e-0719510891144_DN
Diseaseasthma (is_implicated_in)

ELP1 IL18R1 TLR3 MUC7 ALOX5 PROC

2.52e-051571086DOID:2841 (is_implicated_in)
Diseaselysophosphatidylethanolamine 20:4 measurement

SFRP1 FADS2 SEC23A

1.63e-04291083EFO_0010370
DiseaseCrohn's disease

IL18R1 JAK2 PTPRC SULF1 FADS2 UBAC2 IL1R1 TRIB1

2.23e-044411088EFO_0000384
Diseaseinflammatory bowel disease

IL18R1 JAK2 GLMN PTPRC FADS2 UBAC2 TRIB1 PLXNA2

2.52e-044491088EFO_0003767
Diseasebasophil count, eosinophil count

RIN3 IL18R1 JAK2 PTPRC FADS2 UBAC2

2.67e-042411086EFO_0004842, EFO_0005090
DiseaseInherited susceptibility to asthma

MUC7 ALOX5

3.66e-0481082cv:C1869116
DiseaseASTHMA, SUSCEPTIBILITY TO

MUC7 ALOX5

3.66e-0481082600807
DiseaseInhalant adrenergic use measurement

IL18R1 PTPRC FADS2 UBAC2

4.35e-04961084EFO_0009941
Diseaseinterleukin 1 receptor-like 1 measurement

IL18R1 IL1R1

7.14e-04111082EFO_0008168
Diseaseserum ST2 measurement

IL18R1 IL1R1

7.14e-04111082EFO_0005416
DiseaseSitus Inversus

ANKS6 DNAH9

7.14e-04111082C0037221
Diseaseankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis

IL18R1 JAK2 GLMN UBAC2 IL1R1 TRIB1

7.74e-042951086EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
Diseaseomega-6:omega-3 polyunsaturated fatty acid ratio

FADS2 UBAC2 TRIB1

8.25e-04501083EFO_0010732
DiseaseThromboembolism

JAK2 PROC

8.55e-04121082C0040038
Diseasetotal cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement

ANKRD31 FADS2 TRIB1

8.74e-04511083EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Diseasecholesterol to total lipids in small VLDL percentage

ANKRD31 FADS2 TRIB1

8.74e-04511083EFO_0022242
Diseasecholesterol to total lipids in large HDL percentage

ETFDH FADS2 TRIB1

1.09e-03551083EFO_0022234
Diseasefree cholesterol to total lipids in very large HDL percentage

ETFDH FADS2 TRIB1

1.09e-03551083EFO_0022288
Diseasesevere combined immunodeficiency (is_implicated_in)

PTPRC DCLRE1C

1.17e-03141082DOID:627 (is_implicated_in)
Diseasetriglycerides to total lipids in small VLDL percentage

ANKRD31 FADS2 TRIB1

1.27e-03581083EFO_0022338
Diseasecholesteryl esters to total lipids in large HDL percentage

ETFDH FADS2 TRIB1

1.34e-03591083EFO_0022248
Diseaseinterleukin 18 receptor 1 measurement

IL18R1 IL1R1

1.35e-03151082EFO_0008178
Diseasethrombosis (is_implicated_in)

JAK2 PROC

1.35e-03151082DOID:0060903 (is_implicated_in)
Diseasetriglycerides to total lipids in large HDL percentage

ETFDH FADS2 TRIB1

1.40e-03601083EFO_0022330
Diseasefree cholesterol in very large VLDL measurement

ANKRD31 FADS2 TRIB1

1.47e-03611083EFO_0022274
Diseasemonocyte percentage of leukocytes

ETFDH JAK2 GLMN OR52I2 PTPRC PI4KA CTDP1 FADS2 TRIB1

1.48e-037311089EFO_0007989
Diseaseserum albumin measurement

RIN3 SKIDA1 ETFDH ADGRV1 TF FRY FADS2 TRIB1

1.52e-035921088EFO_0004535
Diseasevitamin C measurement

BCAS3 FADS2

1.54e-03161082EFO_0600003
Diseaseeosinophil percentage of leukocytes

RIN3 ZPBP IL18R1 JAK2 PTPRC FADS2 UBAC2 TRIB1 DNMT3L

1.70e-037461089EFO_0007991
Diseaseeosinophil percentage of granulocytes

IL18R1 JAK2 PTPRC UBAC2 DNMT3L

1.73e-032341085EFO_0007996
Diseasetotal lipids in very large HDL measurement

ETFDH FADS2 TRIB1

1.85e-03661083EFO_0022312
Diseasephospholipids in very large HDL measurement

ETFDH FADS2 TRIB1

1.85e-03661083EFO_0022298
Diseasephosphatidylcholine 36:4 measurement

RIPOR2 FADS2

1.95e-03181082EFO_0010382
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

ANKRD31 ETFDH FADS2 TRIB1

1.97e-031441084EFO_0004611, EFO_0020943
Diseasefree cholesterol in large VLDL measurement

ANKRD31 FADS2 TRIB1

2.01e-03681083EFO_0022265
Diseasetotal cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer

ANKRD31 FADS2 TRIB1

2.10e-03691083EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Diseasecholesterol in very large HDL measurement

ETFDH FADS2 TRIB1

2.10e-03691083EFO_0022229
Diseaseportal hypertension (implicated_via_orthology)

JAK2 ALOX5

2.18e-03191082DOID:10762 (implicated_via_orthology)
Diseasesodium-coupled monocarboxylate transporter 1 measurement

FADS2 TRIB1

2.18e-03191082EFO_0802076
DiseaseOmenn Syndrome

PTPRC DCLRE1C

2.18e-03191082C2700553
Diseaseiron biomarker measurement, transferrin measurement

TF FADS2

2.42e-03201082EFO_0004461, EFO_0006341
DiseaseSevere Combined Immunodeficiency

PTPRC DCLRE1C

2.42e-03201082C0085110
Diseasenucleotide measurement

GTDC1 SULF1 PLXNA2

2.46e-03731083EFO_0010513
Diseasetotal lipids in large HDL

ETFDH FADS2 TRIB1

2.56e-03741083EFO_0022189
Diseasefree cholesterol to total lipids in small VLDL percentage

ANKRD31 FADS2 TRIB1

2.66e-03751083EFO_0022287
DiseaseST2 protein measurement

IL18R1 IL1R1

2.66e-03211082EFO_0010599
DiseaseDeep Vein Thrombosis

JAK2 PROC

2.66e-03211082C0149871
DiseaseVenous Thrombosis

JAK2 PROC

2.66e-03211082C0042487
Diseasesaturated fatty acids to total fatty acids percentage

FADS2 TRIB1

2.66e-03211082EFO_0022305
Diseasein situ carcinoma (is_marker_for)

SFRP1 ALOX5

2.66e-03211082DOID:8719 (is_marker_for)
Diseaseasthma, response to diisocyanate

RIPOR2 AP3B1 CTDP1 GREB1 PDZRN4

2.77e-032611085EFO_0006995, MONDO_0004979
DiseaseLung diseases

AP3B1 ADGRE5 DNAAF1

2.97e-03781083C0024115
Diseasecitrate measurement

RNF144A FADS2 TRIB1

3.08e-03791083EFO_0010114
Diseasefree cholesterol in large HDL measurement

ETFDH FADS2 TRIB1

3.08e-03791083EFO_0022157
Diseaseeosinophil count

RIN3 ZPBP DNAJC27 IL18R1 JAK2 GLMN PTPRC FADS2 UBAC2 IL1R1 SNRNP200 TRIB1 DNMT3L

3.09e-03148810813EFO_0004842
Diseasecholesterol in large HDL measurement

ETFDH FADS2 TRIB1

3.19e-03801083EFO_0021900
Diseasenephrotic syndrome (implicated_via_orthology)

NPHS2 ALOX5

3.48e-03241082DOID:1184 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
FNIHDPDYVKILLKR

CYP4Z2P

91

Q8N1L4
RPHCKDFLEKIAKLY

CTDP1

226

Q9Y5B0
FPCQDKKYRHRSLLQ

C8A

51

P07357
TKLVKNCFLPLREYF

DNMT3L

361

Q9UJW3
ALLVPDKCKFLHQER

APP

126

P05067
FLYLLHCLLNKKVRE

ADGRE5

781

P48960
FYEILCSLINPKRKD

ADGRV1

5691

Q8WXG9
KKYIVPHLARACVNF

BTBD3

201

Q9Y2F9
IQFKTPIYDLHCNKR

BCAS3

181

Q9H6U6
RCLPFKHKLEIYISE

CIAO2A

106

Q9H5X1
PDRIDLIHKNYRKLC

AP3B1

216

O00203
PERIDLIHKNYRKLC

AP3B2

211

Q13367
LRPHQKEGIIFLYEC

RAD54B

296

Q9Y620
LELKCKIRNHGEYDL

PDZRN4

631

Q6ZMN7
PKCIRAKIQDYHILT

JAK2

211

O60674
KRLLERYIPKHQKCL

ANKRD31

601

Q8N7Z5
LCAKHGIEYQEKPLL

FADS2

406

O95864
PRVLEKHFGYKLCIF

IL18R1

401

Q13478
CYLPEELAALQKLEH

FLII

46

Q13045
DDPRLGIQKIFLCKY

LLGL2

501

Q6P1M3
NKIYCVRDYHKVLAP

LIMD1

581

Q9UGP4
ALDRLHYEKDPCVKY

NFRKB

626

Q6P4R8
DLELFKKLPFDYIIH

GREB1

1401

Q4ZG55
AYRKLAVLLHPDKCV

DNAJC27

236

Q9NZQ0
PIHRQNYKLDCLITD

EPHX4

136

Q8IUS5
NKDLHIPELRDCRYL

GLB1L3

491

Q8NCI6
IDNPQDLKVHLYKCA

PLXNA2

791

O75051
INHYFCDLVPLLKLA

OR4X2

166

Q8NGF9
QHKDCVVPYLLRLLK

PI4KA

91

P42356
LPCLDTYHKVDLRLQ

NPHS2

156

Q9NP85
IDCYEKYKVLPRIHD

LRPPRC

846

P42704
EHYVNCLDLVNKRLP

POLG2

191

Q9UHN1
CLRTPHLEKRYKIQF

ELP1

476

O95163
DLHYFPTEILCLKNL

LRRC63

356

Q05C16
HCPEKISENKFLKYL

MTPAP

81

Q9NVV4
LDFCILLLYAQPKAK

MGAT4D

236

A6NG13
DFLLIHYDKGPCRNK

RNF144A

221

P50876
KLNHFFYDVKPLLEL

OR12D3

171

Q9UGF7
RIYHFFCDVKPLLKL

OR12D1

171

P0DN82
YIPKLLQLFHTCENL

PPP4R3C

171

Q6ZMV5
LELEKEFHFNKYLCR

HOXB2

156

P14652
YKLGDDLLQCHPAVK

PROC

166

P04070
LLAHQKPFIRKSYKC

MUC7

51

Q8TAX7
PLHVCEQRDVKGLYK

PAPSS1

161

O43252
FHALKIKKNYLPLCA

ETFDH

16

Q16134
KSAVQLFEKHPCLYI

CEPT1

306

Q9Y6K0
FLRLCKKNHDEIYPI

CASP5

171

P51878
LPKREHLQYLYEKLA

DCLRE1C

661

Q96SD1
LRKCSYYIEVLPKHL

FNDC11

71

Q9BVV2
HLKTYPNCFVAKELI

DEPTOR

56

Q8TB45
LLPLVHQCYLKKSKR

GLRX2

146

Q9NS18
LDCKHRDLVDYLDPL

ANKS6

266

Q68DC2
LCKQHKLYITPALND

DNAAF1

96

Q8NEP3
AYRKLALKFHPDKNC

DNAJC18

101

Q9H819
HKVDFILQREPYCRD

KHNYN

651

O15037
ENIHENCLKAIRPYL

DNAH9

3231

Q9NYC9
KECEYNPKFRLILHT

DNAH9

3541

Q9NYC9
EEKQLELCQRLYKLH

FRY

2821

Q5TBA9
QNFCKRPDIIRKHLY

GTDC1

416

Q4AE62
KYEQELFKLALPCLS

RYR2

2656

Q92736
YKDCKPLLLDNIHFS

IL1R1

161

P14778
VKDVLFIRPRKYIHC

JADE3

101

Q92613
PRQLKDKADFCIIHY

MYH10

566

P35580
KSRKNLLHCYEVIPE

PRIMPOL

91

Q96LW4
HCIKGYLLRSEPKRD

RIN3

941

Q8TB24
KLKQAFYIPRNLEHL

OMD

291

Q99983
LELEKEFHFNKYLCR

HOXA2

156

O43364
DRYVAICKPLHYKRI

OR52I2

151

Q8NH67
KEHPRDLKFSIDYIL

FOXL3

186

A0A1W2PRP0
YFLIFDLLVKLCNPK

GLMN

86

Q92990
LLYPLCHKRFQKAFL

HRH4

356

Q9H3N8
LQRLYRLHKDCPKVQ

SERAC1

301

Q96JX3
KDLFHCKPKEILYVC

SLFN14

611

P0C7P3
HRLYQLSKAGKLCVP

AHCYL2

341

Q96HN2
HQLCLKDQPKSRYFL

RNF183

96

Q96D59
IDAKCHKDLPRDIQF

ALOX5

156

P09917
LKKFYEVNHCLPEKI

PIWIL2

796

Q8TC59
LYLLKDFNPLDVHKI

TDRD10

51

Q5VZ19
EEYEPHLFTNKLKCE

SKIDA1

696

Q1XH10
PLQVALECLYHREKR

TEKT5

186

Q96M29
IPDNELHLIKLCAFY

WDR17

1046

Q8IZU2
EILFHYADRALKKCP

VPS8

551

Q8N3P4
IYHRCEFKIPLAIKK

PHAF1

321

Q9BSU1
IPADLRLCHNVGYKK

SFRP1

61

Q8N474
LLLALEPHKEQYKEF

RIPOR2

611

Q9Y4F9
IRLCQKFGEYHKDDP

SEC23A

551

Q15436
REHVVKIPLKRCQFY

SEMA5A

476

Q13591
KQHDCDYKILPALGV

TET1

136

Q8NFU7
HCVLPKDQSILLKYQ

CCDC15

431

Q0P6D6
KFLYCEPHKRIKEVL

C11orf97

51

A0A1B0GVM6
VHLEVLNARQPYKCK

ZNF561

186

Q8N587
FLEEIPDYKLNHALC

TLR3

851

O15455
TEFYKHCGPRLKILQ

UNC80

2501

Q8N2C7
ELRCKVFPIKHYQDK

TRIB1

116

Q96RU8
RKPVDEYKDCHLAQV

TF

251

P02787
KRPENYFKHIKEACI

RINT1

721

Q6NUQ1
DHPIDLLLRDFKKNY

SPARCL1

571

Q14515
DYKLKNIFRLHELPV

SPAG16

341

Q8N0X2
HNCEPYKRLFKAKNL

ZPBP

251

Q9BS86
RQRFLHCTEKDLIPY

SNRNP200

1586

O75643
EKPYRYIECDKALNH

ZNF415

261

Q09FC8
YLKFIELPLTQRKFC

ZCCHC4

111

Q9H5U6
AEFKKEEPRALYIHC

ZMYM1

731

Q5SVZ6
ALLLPHCQKLFVYDL

UBAC2

31

Q8NBM4
YPEINRFLKLLHQCK

TYW1

491

Q9NV66
QSNHLPKYERVKELC

SULF1

431

Q8IWU6
HKRCPDYIIQKLNIV

PTPRC

786

P08575
FQDIPKRCLKAREHF

TSN

51

Q15631
KPKTFQAYLDDCHRR

YPEL3

6

P61236
EDKLRHFRECFYIPK

KYNU

36

Q16719
ALRHLYVLVNLCEKP

LGMN

401

Q99538