Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled acetylcholine receptor activity	CHRM2 CHRM3 CHRM5	3.72e-07	7	45	3	GO:0016907
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity	CHRM2 CHRM3 CHRM5	3.01e-06	13	45	3	GO:0099528
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	CHRM2 CHRM3 CHRM5	1.60e-05	22	45	3	GO:0004993
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRM2 CHRM3 CHRM5	1.84e-05	23	45	3	GO:0015464
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	CHRM2 CHRM3 CHRM5	1.07e-04	41	45	3	GO:0008227
GeneOntologyMolecularFunction	complement component C3b binding	CFHR4 CFHR3	3.23e-04	12	45	2	GO:0001851
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP2 OLR1	5.84e-04	16	45	2	GO:0005041
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	CHRM2 CHRM3 CHRM5	6.45e-04	75	45	3	GO:0098960
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP2 OLR1	1.01e-03	21	45	2	GO:0030228
GeneOntologyMolecularFunction	opsonin binding	CFHR4 CFHR3	1.44e-03	25	45	2	GO:0001846
GeneOntologyMolecularFunction	neurotransmitter receptor activity	CHRM2 CHRM3 CHRM5	1.48e-03	100	45	3	GO:0030594
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	CHRM3 CHRM5	1.56e-03	26	45	2	GO:0004435
GeneOntologyMolecularFunction	phospholipase C activity	CHRM3 CHRM5	1.94e-03	29	45	2	GO:0004629
GeneOntologyMolecularFunction	complement binding	CFHR4 CFHR3	2.36e-03	32	45	2	GO:0001848
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	CHRM2 CHRM3 CHRM5	6.57e-07	8	48	3	GO:0007197
GeneOntologyBiologicalProcess	G protein-coupled serotonin receptor signaling pathway	CHRM2 CHRM3 CHRM5	2.03e-05	23	48	3	GO:0098664
GeneOntologyBiologicalProcess	G protein-coupled acetylcholine receptor signaling pathway	CHRM2 CHRM3 CHRM5	2.62e-05	25	48	3	GO:0007213
GeneOntologyBiologicalProcess	positive regulation of oligodendrocyte progenitor proliferation	LRP2 SHH	7.91e-05	6	48	2	GO:0070447
GeneOntologyCellularComponent	receptor complex	PLA2R1 PTPRA TRBV11-3 TRBV11-2 TRBV11-1 LRP2 PKD1L3 OLR1	4.80e-05	581	48	8	GO:0043235
GeneOntologyCellularComponent	dendrite	ZMYND8 BRINP2 LRP2 SHH PLEC CHRM2 CHRM3 CHRM5	6.84e-04	858	48	8	GO:0030425
GeneOntologyCellularComponent	dendritic tree	ZMYND8 BRINP2 LRP2 SHH PLEC CHRM2 CHRM3 CHRM5	6.95e-04	860	48	8	GO:0097447
Domain	Musac_Ach_rcpt	CHRM2 CHRM3 CHRM5	1.39e-07	5	46	3	IPR000995
Domain	Lectin_C	PLA2R1 PKD1L3 OLR1	1.16e-03	84	46	3	PF00059
Domain	C-type_lectin-like	PLA2R1 PKD1L3 OLR1	1.24e-03	86	46	3	IPR001304
Domain	-	PLA2R1 PKD1L3 OLR1	1.75e-03	97	46	3	3.10.100.10
Domain	C-type_lectin-like/link	PLA2R1 PKD1L3 OLR1	1.86e-03	99	46	3	IPR016186
Domain	CTDL_fold	PLA2R1 PKD1L3 OLR1	2.32e-03	107	46	3	IPR016187
Domain	Sushi	CFHR4 CFHR3	7.28e-03	52	46	2	PF00084
Domain	CCP	CFHR4 CFHR3	7.83e-03	54	46	2	SM00032
Domain	SUSHI	CFHR4 CFHR3	8.40e-03	56	46	2	PS50923
Domain	Sushi_SCR_CCP_dom	CFHR4 CFHR3	8.69e-03	57	46	2	IPR000436
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM2 CHRM3 CHRM5	9.60e-08	5	31	3	M27300
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM2 CHRM3 CHRM5	9.60e-08	5	31	3	MM15006
Pathway	WP_MONOAMINE_GPCRS	CHRM2 CHRM3 CHRM5	4.15e-05	31	31	3	MM15871
Pathway	WP_MONOAMINE_GPCRS	CHRM2 CHRM3 CHRM5	5.02e-05	33	31	3	M39585
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFHR4 CFHR3	6.98e-05	6	31	2	M47880
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	CHRM2 CHRM3 CHRM5	1.04e-04	42	31	3	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	CHRM2 CHRM3 CHRM5	1.04e-04	42	31	3	MM14971
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	LRP2 SHH	1.67e-04	9	31	2	M47893
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	CHRM3 CHRM5	8.68e-04	20	31	2	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	CHRM3 CHRM5	9.58e-04	21	31	2	M47689
Pathway	PID_HEDGEHOG_2PATHWAY	LRP2 SHH	1.05e-03	22	31	2	M211
Pubmed	Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C.	CHRM2 CHRM3 CHRM5	1.05e-08	4	49	3	8576254
Pubmed	Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	20940295
Pubmed	Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	26084221
Pubmed	Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	15919709
Pubmed	Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	12675128
Pubmed	Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	15913791
Pubmed	Muscarinic acetylcholine receptor subtypes: localization and structure/function.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	8248499
Pubmed	The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	30914695
Pubmed	Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	15661360
Pubmed	Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	24695732
Pubmed	Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	7648406
Pubmed	Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	15574798
Pubmed	Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	11306684
Pubmed	Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	12151512
Pubmed	Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	29401598
Pubmed	Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	19213795
Pubmed	The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	18755247
Pubmed	Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	20463237
Pubmed	Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.	CHRM2 CHRM3 CHRM5	2.62e-08	5	49	3	19940190
Pubmed	The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.	CHRM2 CHRM3 CHRM5	5.24e-08	6	49	3	19182865
Pubmed	Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.	CHRM2 CHRM3 CHRM5	5.24e-08	6	49	3	31914675
Pubmed	A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development.	CHRM2 CHRM3 CHRM5	9.16e-08	7	49	3	35427599
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRM2 CHRM3 CHRM5	3.13e-07	10	49	3	10336173
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	CHRM2 CHRM3 CHRM5	1.76e-06	17	49	3	10549128
Pubmed	Calcium mobilization by activation of M(3)/M(5) muscarinic receptors in the human retinoblastoma.	CHRM3 CHRM5	1.94e-06	2	49	2	17951979
Pubmed	Cholinergic responses of ophthalmic arteries in M3 and M5 muscarinic acetylcholine receptor knockout mice.	CHRM3 CHRM5	1.94e-06	2	49	2	19407017
Pubmed	Roles of M2 and M3 muscarinic receptors in the generation of rhythmic motor activity in mouse small intestine.	CHRM2 CHRM3	1.94e-06	2	49	2	23889852
Pubmed	Muscarinic suppression of ATP-sensitive K+ channels mediated by the M3/Gq/11/phospholipase C pathway contributes to mouse ileal smooth muscle contractions.	CHRM2 CHRM3	1.94e-06	2	49	2	30001145
Pubmed	M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gbetagamma-mediated inhibition of large conductance Ca2+-activated K+ channel activity.	CHRM2 CHRM3	1.94e-06	2	49	2	18524769
Pubmed	Histological determination of the areas enriched in cholinergic terminals and M2 and M3 muscarinic receptors in the mouse central auditory system.	CHRM2 CHRM3	1.94e-06	2	49	2	20665816
Pubmed	Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice.	CHRM2 CHRM3	1.94e-06	2	49	2	17099717
Pubmed	Gastric body cholinergic contractile signal transduction in M2 and M3 receptor knockout mice.	CHRM2 CHRM3	1.94e-06	2	49	2	23786223
Pubmed	[Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization].	CHRM2 CHRM3	1.94e-06	2	49	2	22610841
Pubmed	Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable.	CHRM2 CHRM3	1.94e-06	2	49	2	12486155
Pubmed	Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice.	CHRM2 CHRM3	1.94e-06	2	49	2	33477687
Pubmed	Muscarinic receptor-mediated bronchoconstriction is coupled to caveolae in murine airways.	CHRM2 CHRM3	1.94e-06	2	49	2	20023174
Pubmed	Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors.	CHRM2 CHRM3	1.94e-06	2	49	2	14977875
Pubmed	Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination.	CHRM2 CHRM3	1.94e-06	2	49	2	12694864
Pubmed	Cigarette smoking promotes inflammation in patients with COPD by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor 3 and 5 expression.	CHRM3 CHRM5	1.94e-06	2	49	2	25375131
Pubmed	Muscarinic receptor expression increases following exposure to intravesical pressures of < or =40 cm-H2O: a possible mechanism for pressure-induced cell proliferation.	CHRM2 CHRM3	1.94e-06	2	49	2	18563417
Pubmed	Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to acetylcholine.	CHRM2 CHRM3	1.94e-06	2	49	2	15130910
Pubmed	The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization.	CHRM3 CHRM5	1.94e-06	2	49	2	20398705
Pubmed	Sequence and expression of a novel human T-cell receptor beta-chain variable gene segment subfamily.	TRBV11-3 TRBV11-1	1.94e-06	2	49	2	2272661
Pubmed	Mutation screening of the muscarinic m2 and m3 receptor genes in asthmatics, outgrow subjects, and normal controls.	CHRM2 CHRM3	1.94e-06	2	49	2	12381439
Pubmed	Further characterization of the synergistic activation mechanism of cationic channels by M2 and M3 muscarinic receptors in mouse intestinal smooth muscle cells.	CHRM2 CHRM3	1.94e-06	2	49	2	31875697
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRM2 CHRM3 CHRM5	2.51e-06	19	49	3	17373692
Pubmed	The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling.	CHRM2 CHRM3	5.83e-06	3	49	2	17065150
Pubmed	Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells.	CHRM2 CHRM3	5.83e-06	3	49	2	17463038
Pubmed	Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin.	CFHR4 CFHR3	5.83e-06	3	49	2	10622723
Pubmed	Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.	CHRM2 CHRM3	5.83e-06	3	49	2	12713643
Pubmed	Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.	CHRM3 CHRM5	5.83e-06	3	49	2	16956767
Pubmed	Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice.	CHRM2 CHRM3	5.83e-06	3	49	2	14645675
Pubmed	Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.	CHRM2 CHRM5	5.83e-06	3	49	2	23649821
Pubmed	Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility.	CHRM2 CHRM3	5.83e-06	3	49	2	11961069
Pubmed	Localization of muscarinic receptors M1R, M2R and M3R in the human colon.	CHRM2 CHRM3	5.83e-06	3	49	2	20146726
Pubmed	CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.	CHRM2 CHRM3	5.83e-06	3	49	2	24430298
Pubmed	M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.	CHRM3 CHRM5	5.83e-06	3	49	2	15146045
Pubmed	Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.	CHRM2 CHRM3	5.83e-06	3	49	2	26516777
Pubmed	Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.	CHRM2 CHRM3	5.83e-06	3	49	2	24156289
Pubmed	M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: Findings obtained with muscarinic-receptor knockout mouse.	CHRM2 CHRM3	5.83e-06	3	49	2	17008557
Pubmed	Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors.	CHRM2 CHRM3	5.83e-06	3	49	2	15933222
Pubmed	Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice.	CHRM2 CHRM3	5.83e-06	3	49	2	18078830
Pubmed	Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics.	CHRM2 CHRM3	5.83e-06	3	49	2	27923235
Pubmed	Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.	CHRM3 CHRM5	5.83e-06	3	49	2	1905013
Pubmed	Two factor H-related proteins from the mouse: expression analysis and functional characterization.	CFHR4 CFHR3	5.83e-06	3	49	2	17028856
Pubmed	Expression and distribution of cholinergic receptors in the human urothelium.	CHRM2 CHRM3	5.83e-06	3	49	2	17335853
Pubmed	Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors.	CHRM2 CHRM3	5.83e-06	3	49	2	16110248
Pubmed	Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.	CHRM3 CHRM5	5.83e-06	3	49	2	3272174
Pubmed	Localization of complement factor H gene expression and protein distribution in the mouse outer retina.	CFHR4 CFHR3	5.83e-06	3	49	2	25684976
Pubmed	Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene.	CHRM2 CHRM3	5.83e-06	3	49	2	2848036
Pubmed	Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice.	CHRM2 CHRM3	5.83e-06	3	49	2	17878406
Pubmed	Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization.	CHRM2 CHRM3	5.83e-06	3	49	2	16368694
Pubmed	M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.	CHRM3 CHRM5	5.83e-06	3	49	2	19657040
Pubmed	Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.	CFHR4 CFHR3	5.83e-06	3	49	2	21637784
Pubmed	M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.	CHRM2 CHRM3	5.83e-06	3	49	2	17192665
Pubmed	Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.	CHRM2 CHRM3	5.83e-06	3	49	2	23397297
Pubmed	M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice.	CHRM2 CHRM3	5.83e-06	3	49	2	15965495
Pubmed	Distinct mixtures of muscarinic receptor subtypes mediate inhibition of noradrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice.	CHRM2 CHRM3	5.83e-06	3	49	2	15965496
Pubmed	Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice.	CHRM3 CHRM5	5.83e-06	3	49	2	15691866
Pubmed	Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice.	CHRM3 CHRM5	5.83e-06	3	49	2	21335473
Pubmed	Ultrasonic vocalizations induced by sex and amphetamine in M2, M4, M5 muscarinic and D2 dopamine receptor knockout mice.	CHRM2 CHRM5	1.16e-05	4	49	2	18382674
Pubmed	Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.	CHRM3 CHRM5	1.16e-05	4	49	2	8063729
Pubmed	Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes.	CHRM2 CHRM5	1.16e-05	4	49	2	11855742
Pubmed	Muscarinic receptor subtypes. Physiology and clinical implications.	CHRM2 CHRM3	1.16e-05	4	49	2	2674717
Pubmed	Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes.	CHRM2 CHRM3	1.16e-05	4	49	2	18348264
Pubmed	Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes.	CHRM2 CHRM3	1.16e-05	4	49	2	2739737
Pubmed	Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells.	CHRM2 CHRM3	1.16e-05	4	49	2	17851256
Pubmed	Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors.	CHRM2 CHRM3	1.16e-05	4	49	2	9603968
Pubmed	Identification of a family of muscarinic acetylcholine receptor genes.	CHRM2 CHRM3	1.16e-05	4	49	2	3037705
Pubmed	Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling.	CHRM2 CHRM3	1.16e-05	4	49	2	15147302
Pubmed	Ciliary activity in the oviduct of cycling, pregnant, and muscarinic receptor knockout mice.	CHRM3 CHRM5	1.16e-05	4	49	2	22302687
Pubmed	CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.	CFHR4 CFHR3	1.16e-05	4	49	2	36793547
Pubmed	Muscarinic acetylcholine receptors in the mouse esophagus: focus on intraganglionic laminar endings (IGLEs).	CHRM2 CHRM3	1.16e-05	4	49	2	23742744
Pubmed	β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints.	CHRM2 CHRM3	1.16e-05	4	49	2	27978539
Pubmed	Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.	CHRM2 CHRM3	1.16e-05	4	49	2	3443095
Pubmed	M(1)/M(3) and M(2)/M(4) muscarinic receptor double-knockout mice present distinct respiratory phenotypes.	CHRM2 CHRM3	1.16e-05	4	49	2	18206430
Pubmed	Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response.	CHRM2 CHRM3	1.16e-05	4	49	2	19183167
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	NDC1 UBR5 NOC2L HASPIN PLEC	1.18e-05	210	49	5	16565220
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	PLA2R1 PTPRA LRP2 OLR1	1.28e-05	101	49	4	23382219
Pubmed	Factor H-related proteins determine complement-activating surfaces.	CFHR4 CFHR3	1.94e-05	5	49	2	25979655
Interaction	GPRASP1 interactions	LRP2 CHRM2 CHRM3 CHRM5	1.64e-05	67	46	4	int:GPRASP1
Interaction	UPK1A interactions	LMF2 NDC1 SLC49A4 ALG8 CERS6	2.29e-05	150	46	5	int:UPK1A
Interaction	RGS7 interactions	CHRM2 CHRM3 CHRM5	2.47e-05	25	46	3	int:RGS7
Cytoband	7q34	TRBV11-3 TRBV11-2 TRBV11-1	7.70e-04	167	49	3	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV11-3 TRBV11-2 TRBV11-1	1.03e-03	185	49	3	chr7q34
Cytoband	1q32	CFHR4 CFHR3	1.27e-03	49	49	2	1q32
Cytoband	Ensembl 112 genes in cytogenetic band chr7q33	SLC35B4 CHRM2	1.78e-03	58	49	2	chr7q33
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFHR4 CFHR3	2.95e-03	75	49	2	chr1q31
GeneFamily	Cholinergic receptors muscarinic	CHRM2 CHRM3 CHRM5	6.63e-08	5	35	3	180
GeneFamily	T cell receptor beta locus at 7q34	TRBV11-3 TRBV11-2 TRBV11-1	6.30e-04	87	35	3	372
GeneFamily	Complement system\|Sushi domain containing	CFHR4 CFHR3	2.20e-03	36	35	2	492
GeneFamily	C-type lectin domain family	PLA2R1 OLR1	3.73e-03	47	35	2	494
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFHR4 CFHR3	5.44e-03	57	35	2	1179
Drug	Botiacrine	CHRM2 CHRM3 CHRM5	3.08e-08	4	46	3	CID000071202
Drug	AC1NSJZ2	CHRM2 CHRM3 CHRM5 GNL3	3.40e-08	17	46	4	CID005311091
Drug	tripitramine	CHRM2 CHRM3 CHRM5 GNL3	4.37e-08	18	46	4	CID000132947
Drug	Atropine	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB00572
Drug	Fesoterodine	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB06702
Drug	Darifenacin	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB00496
Drug	Metixene	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB00340
Drug	Trihexyphenidyl	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB00376
Drug	Solifenacin	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB01591
Drug	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	ctd:C568516
Drug	Pipecuronium	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	ctd:D017300
Drug	N-Methylscopolamine	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	ctd:D019832
Drug	eucatropine	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	CID000007534
Drug	Tolterodine	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB01036
Drug	Cryptenamine	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB00785
Drug	Homatropine Methylbromide	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	DB00725
Drug	Quinuclidinyl Benzilate	CHRM2 CHRM3 CHRM5	7.70e-08	5	46	3	ctd:D011813
Drug	lofepramine	PLEC CHRM2 CHRM3 CHRM5	1.26e-07	23	46	4	CID000003947
Drug	Nsc34399	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	CID000003622
Drug	Gallamine Triethiodide	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	ctd:D005703
Drug	Dactil	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	CID000004839
Drug	4-diphenylacetoxy-1,1-dimethylpiperidinium	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	ctd:C042375
Drug	brucine N-oxide	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	ctd:C083067
Drug	Brompheniramine	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	DB00835
Drug	Benzquinamide	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	DB00767
Drug	Scopolamine	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	DB00747
Drug	Crotalid Venoms	CHRM2 CHRM3 CHRM5	1.54e-07	6	46	3	ctd:D003435
Drug	Tiotropium Bromide	CHRM2 CHRM3 CHRM5	2.69e-07	7	46	3	ctd:D000069447
Drug	secoverine	CHRM2 CHRM3 CHRM5	4.29e-07	8	46	3	CID000042470
Drug	Maprotiline	CHRM2 CHRM3 CHRM5	4.29e-07	8	46	3	DB00934
Drug	Paroxetine	CHRM2 CHRM3 CHRM5	4.29e-07	8	46	3	DB00715
Drug	Rilapinum	CHRM2 CHRM3 CHRM5	6.43e-07	9	46	3	CID006446980
Drug	Trest	CHRM2 CHRM3 CHRM5	6.43e-07	9	46	3	CID000004167
Drug	sila-hexocyclium	CHRM2 CHRM3 CHRM5	6.43e-07	9	46	3	CID000130169
Drug	AC1L1AYE	CHRM2 CHRM3 CHRM5 GNL3	8.19e-07	36	46	4	CID000001205
Drug	Promethazine	CHRM2 CHRM3 CHRM5	9.17e-07	10	46	3	DB01069
Drug	tenilapine	CHRM2 CHRM3 CHRM5	9.17e-07	10	46	3	CID006450478
Drug	homatropin	CHRM2 CHRM3 CHRM5	1.26e-06	11	46	3	CID000003623
Drug	Imipramine	CHRM2 CHRM3 CHRM5	1.26e-06	11	46	3	DB00458
Drug	Pancuronium	CHRM2 CHRM3 CHRM5	1.26e-06	11	46	3	ctd:D010197
Drug	cyclopentolate	CHRM2 CHRM3 CHRM5	1.26e-06	11	46	3	CID000002905
Drug	dicyclomine	CHRM2 CHRM3 CHRM5	1.26e-06	11	46	3	CID000003042
Drug	rocuronium	CHRM2 CHRM3 CHRM5	1.26e-06	11	46	3	ctd:C061870
Drug	Nortriptyline	CHRM2 CHRM3 CHRM5	1.68e-06	12	46	3	DB00540
Drug	AQ-RA 741	CHRM2 CHRM3 CHRM5	1.68e-06	12	46	3	CID000129989
Drug	Chlorprothixene	CHRM2 CHRM3 CHRM5	1.68e-06	12	46	3	DB01239
Drug	Vecuronium Bromide	CHRM2 CHRM3 CHRM5	1.68e-06	12	46	3	ctd:D014673
Drug	Tropicamide	CHRM2 CHRM3 CHRM5	1.68e-06	12	46	3	ctd:D014331
Drug	Desipramine	CHRM2 CHRM3 CHRM5	2.18e-06	13	46	3	DB01151
Drug	propiomazine	CHRM2 CHRM3 CHRM5	2.77e-06	14	46	3	CID000004940
Drug	Promazine	CHRM2 CHRM3 CHRM5	2.77e-06	14	46	3	DB00420
Drug	methoctramine	CHRM2 CHRM3 CHRM5	2.77e-06	14	46	3	ctd:C054938
Drug	Propiomazine	CHRM2 CHRM3 CHRM5	2.77e-06	14	46	3	DB00777
Drug	Nicardipine	CHRM2 CHRM3 CHRM5	2.77e-06	14	46	3	DB00622
Drug	NSC172130	CHRM2 CHRM3 CHRM5	3.45e-06	15	46	3	CID000003155
Drug	N-chloromethylbrucine	CHRM2 CHRM3	3.99e-06	2	46	2	ctd:C118330
Drug	caracurine	CHRM2 CHRM3	3.99e-06	2	46	2	ctd:C006890
Drug	dimethyl-W84	CHRM2 CHRM5	3.99e-06	2	46	2	ctd:C113497
Drug	PGW5 compound	CHRM2 CHRM3 CHRM5	5.15e-06	17	46	3	ctd:C000593032
Drug	Amitriptyline	CHRM2 CHRM3 CHRM5	6.17e-06	18	46	3	DB00321
Drug	aprophen	CHRM2 CHRM3 CHRM5	6.17e-06	18	46	3	CID000071128
Drug	Methotrimeprazine	CHRM2 CHRM3 CHRM5	7.31e-06	19	46	3	DB01403
Drug	femoxitine	CHRM2 CHRM3 CHRM5	7.31e-06	19	46	3	CID000043103
Drug	methoctramine	CHRM2 CHRM3 CHRM5 GNL3	7.96e-06	63	46	4	CID000004108
Drug	bromperidol	CHRM2 CHRM3 CHRM5	8.59e-06	20	46	3	CID000002448
Drug	Doxepin	CHRM2 CHRM3 CHRM5	8.59e-06	20	46	3	DB01142
Drug	telenzepine	CHRM2 CHRM3 CHRM5	1.16e-05	22	46	3	CID000005387
Drug	Anisotropine Methylbromide	CHRM2 CHRM3	1.20e-05	3	46	2	DB00517
Drug	Tridihexethyl	CHRM2 CHRM3	1.20e-05	3	46	2	DB00505
Drug	Methylscopolamine	CHRM2 CHRM3	1.20e-05	3	46	2	DB00462
Drug	Ipratropium bromide	CHRM2 CHRM3	1.20e-05	3	46	2	DB00332
Drug	Oxyphencyclimine	CHRM2 CHRM3	1.20e-05	3	46	2	DB00383
Drug	bromomethane;[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate	CHRM2 CHRM3	1.20e-05	3	46	2	CID011954288
Drug	Tiotropium	CHRM2 CHRM3	1.20e-05	3	46	2	DB01409
Drug	Pipecuronium	CHRM2 CHRM3	1.20e-05	3	46	2	DB01338
Drug	Pancuronium	CHRM2 CHRM3	1.20e-05	3	46	2	DB01337
Drug	Diphenidol	CHRM2 CHRM3	1.20e-05	3	46	2	DB01231
Drug	Pilocarpine	CHRM2 CHRM3	1.20e-05	3	46	2	DB01085
Drug	Oxybutynin	CHRM2 CHRM3	1.20e-05	3	46	2	DB01062
Drug	(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine	CHRM2 CHRM3	1.20e-05	3	46	2	ctd:C425227
Drug	oxyphencyclimine	CHRM2 CHRM3	1.20e-05	3	46	2	CID000004642
Drug	darifenacin	CHRM2 CHRM3	1.20e-05	3	46	2	ctd:C101207
Drug	biperiden	CHRM2 CHRM3 CHRM5	1.33e-05	23	46	3	CID000002381
Drug	procyclidine	CHRM2 CHRM3 CHRM5	1.52e-05	24	46	3	CID000004919
Drug	Olanzapine	CHRM2 CHRM3 CHRM5	1.72e-05	25	46	3	DB00334
Drug	Ziprasidone	CHRM2 CHRM3 CHRM5	1.72e-05	25	46	3	DB00246
Drug	Aripiprazole	CHRM2 CHRM3 CHRM5	1.72e-05	25	46	3	DB01238
Drug	benzquinamide	CHRM2 CHRM3 CHRM5	1.94e-05	26	46	3	CID000002342
Drug	Clozapine	CHRM2 CHRM3 CHRM5	1.94e-05	26	46	3	DB00363
Drug	tardan	CHRM2 CHRM3 CHRM5	1.94e-05	26	46	3	CID000002729
Drug	Quetiapine	CHRM2 CHRM3 CHRM5	1.94e-05	26	46	3	DB01224
Drug	T15550	CHRM2 CHRM3 CHRM5	1.94e-05	26	46	3	CID000005454
Drug	cyamemazine	CHRM2 CHRM3 CHRM5	1.94e-05	26	46	3	CID000062865
Drug	fluperlapine	CHRM2 CHRM3 CHRM5	2.18e-05	27	46	3	CID000049381
Drug	furtrethonium	CHRM2 CHRM3	2.39e-05	4	46	2	ctd:C028530
Drug	Hyoscyamine	CHRM2 CHRM3	2.39e-05	4	46	2	DB00424
Drug	Procyclidine	CHRM2 CHRM3	2.39e-05	4	46	2	DB00387
Drug	Disopyramide	CHRM2 CHRM3	2.39e-05	4	46	2	DB00280
Drug	hexocyclium	CHRM2 CHRM5	2.39e-05	4	46	2	CID000024199
Drug	5-methylfurtrethonium	CHRM2 CHRM3	2.39e-05	4	46	2	ctd:C008446
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFHR4 CFHR3	1.42e-05	4	46	2	EFO_0803292
Disease	Drug habituation	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C0013170
Disease	Substance-Related Disorders	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C0236969
Disease	Drug abuse	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C0013146
Disease	Drug Use Disorders	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C0013222
Disease	Drug Dependence	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C1510472
Disease	Substance Dependence	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C0038580
Disease	Substance Use Disorders	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C0029231
Disease	Prescription Drug Abuse	PLA2R1 CERS6 SLC2A13 CHRM2	3.15e-05	115	46	4	C4316881
Disease	Substance abuse problem	PLA2R1 CERS6 SLC2A13 CHRM2	3.26e-05	116	46	4	C0740858
Disease	Hemolytic-uremic syndrome	CFHR4 CFHR3	8.50e-05	9	46	2	cv:C0019061
Disease	Atypical hemolytic-uremic syndrome	CFHR4 CFHR3	8.50e-05	9	46	2	cv:C2931788
Disease	insomnia measurement	MTA3 UBR5 SLC35B4 ZMYND8 SLC2A13	6.16e-04	443	46	5	EFO_0007876
Disease	apolipoprotein L1 measurement	CPN2 PKD1L3	6.97e-04	25	46	2	EFO_0021854
Disease	corpus callosum central volume measurement	SHH PLEC	8.76e-04	28	46	2	EFO_0010296
Disease	Age related macular degeneration	CFHR4 CFHR3	1.01e-03	30	46	2	C0242383
Disease	Complement deficiency disease	CFHR4 CFHR3	1.22e-03	33	46	2	C0272242
Disease	pack-years measurement, systolic blood pressure	DCHS1 LRP2	1.29e-03	34	46	2	EFO_0006335, EFO_0006526

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYYAPHLDQTGNWPW	EPC1	411	Q9H2F5
PWQCDCHLAYLFNWL	CPN2	396	P22792
QLWISGLYTSAYWCG	ABCA6	1046	Q8N139
WNLGYWLCYINSTVN	CHRM3	526	P20309
HYWNAWLPLLSSAVY	CFAP46	1036	Q8IYW2
CIPNTVWTIGYWLCY	CHRM2	416	P08172
WYNACAHSNLNGVWY	ANGPTL1	441	O95841
PYSWHYAPWTKCSAQ	ADAMTS10	826	Q9H324
YNWDYLLSWCPQFQP	DCHS1	3161	Q96JQ0
QTGLYIGWRCPHYLW	FAM221B	246	A6H8Z2
PCQGYLYWADWDTHA	LRP2	2516	P98164
LALHPQYGYLYWADW	LRP2	3326	P98164
GLQFLYSPWWCLAAA	OLR1	26	P78380
QSVYNWQYVHCLFLW	NOC2L	401	Q9Y3T9
YSPWGQEFSICNYWH	PPT2	166	Q9UMR5
YWDYIHCTQNGWSPA	CFHR3	66	Q02985
YCHVEEWLLSPNYAW	IGSF3	781	O75054
YLVCNYSPKGNWWGH	CRISPLD1	201	Q9H336
TFYHTELSWFNWCLP	SLC49A4	436	Q96SL1
LHLSWYYLFAWGPAI	FRRS1L	221	Q9P0K9
TPWLWNTRHCWYNYP	CERS6	156	Q6ZMG9
SYWDYIHCTQDGWSP	CFHR4	66	Q92496
NRWGEYHPYSNVLWL	HASPIN	731	Q8TF76
WSEWTGASLAYYCHP	GNL3	391	Q9BVP2
WNTSYCDYPCQQAHW	ZMYND8	1041	Q9ULU4
QVHEWLWQSYCGYLT	FAM8A1	116	Q9UBU6
LWQSYCGYLTWHSGL	FAM8A1	121	Q9UBU6
AQYWPDQGCWTYGNI	PTPRA	351	P18433
AYHGSYLWLQKLWIC	MAP4K1	76	Q92918
SCYATQSHQWYSWGP	MTA3	381	Q9BTC8
WAYNFCPTPYSWTAL	SLC2A13	496	Q96QE2
HNWTYWQCGQYLGVG	RSAD1	286	Q9HA92
LYFQNPFTLWHWLGT	SLC35B4	286	Q969S0
GIHWYSQLLYQIGTW	SHH	431	Q15465
YPSNYNAWSHRIWVL	PTAR1	191	Q7Z6K3
CPAWWGLTALTYHYE	LMF2	191	Q9BU23
YYWEIHNQTWSSAGC	PKD1L3	636	Q7Z443
WKYYATHCEPGWNPY	PLA2R1	371	Q13018
YWWNRIQSLLYCGES	BRINP2	416	Q9C0B6
CVPVTLWHLGYWLCY	CHRM5	471	P08912
LWHLGYWLCYVNSTV	CHRM5	476	P08912
LCHAYWAPNFWALYN	ALG8	276	Q9BVK2
YLSGLEYWNDIHWSC	TASL	6	Q9HAI6
KCSPNYLGSDWYNTW	SMRP1	96	Q8NCR6
WCNPISGHATLYWYQ	TRBV11-2	41	A0A584
WCNPISGHNTLYWYL	TRBV11-3	41	A0A5A6
AWCHFYWYLTNEGIA	PLEC	66	Q15149
WCDPISGHATLYWYR	TRBV11-1	41	A0A0K0K1C0
SWYLCPYSQAWVSLG	TBC1D28	191	Q2M2D7
EVCWPQLLYPWTQYY	TCTN2	646	Q96GX1
HGLSGNWLAYWQYEI	WDR81	1611	Q562E7
LYTCAQLENSLYWWG	UBR5	481	O95071
YHVWLCGVFLLTTWY	NDC1	271	Q9BTX1