Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	8.01e-08	5	41	3	GO:0030156
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	2.46e-05	4	41	2	GO:0001602
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	2.24e-04	11	41	2	GO:0004983
GeneOntologyMolecularFunction	D-mannose binding	MRC1 IGF2R	1.40e-03	27	41	2	GO:0005537
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	GPR84 NPY4R2 NPY4R	2.56e-03	133	41	3	GO:0008528
GeneOntologyMolecularFunction	neuropeptide binding	NPY4R2 NPY4R	2.62e-03	37	41	2	GO:0042923
GeneOntologyMolecularFunction	peptide receptor activity	GPR84 NPY4R2 NPY4R	2.96e-03	140	41	3	GO:0001653
GeneOntologyMolecularFunction	carbohydrate binding	MRC1 IGF2R CLEC20A DCDC1	3.67e-03	310	41	4	GO:0030246
GeneOntologyMolecularFunction	peptide binding	MEMO1 HSPG2 NPY4R2 NPY4R	4.02e-03	318	41	4	GO:0042277
GeneOntologyMolecularFunction	beta-tubulin binding	EML4 BCAS3	4.55e-03	49	41	2	GO:0048487
GeneOntologyBiologicalProcess	neuromuscular synaptic transmission	RIMBP3 RIMBP3C RIMBP3B	4.61e-05	36	40	3	GO:0007274
GeneOntologyBiologicalProcess	cellular response to interleukin-6	PTPN2 SBNO2 MYB	9.06e-05	45	40	3	GO:0071354
GeneOntologyBiologicalProcess	response to interleukin-6	PTPN2 SBNO2 MYB	1.17e-04	49	40	3	GO:0070741
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	2.39e-05	28	42	3	GO:0002177
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	9.34e-06	19	31	3	MP:0009377
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	1.28e-05	21	31	3	MP:0008893
MousePheno	detached acrosome	RIMBP3 RIMBP3C RIMBP3B	1.23e-04	44	31	3	MP:0009231
MousePheno	abnormal manchette morphology	RIMBP3 RIMBP3C RIMBP3B	1.32e-04	45	31	3	MP:0009376
Domain	NPY4_rcpt	NPY4R2 NPY4R	4.25e-06	2	39	2	IPR001933
Domain	NPY_rcpt	NPY4R2 NPY4R	1.52e-04	9	39	2	IPR000611
Domain	-	MRC1 IGF2R	3.27e-04	13	39	2	2.10.10.10
Domain	FN_type2_col-bd	MRC1 IGF2R	3.81e-04	14	39	2	IPR000562
Domain	FN2_2	MRC1 IGF2R	3.81e-04	14	39	2	PS51092
Domain	fn2	MRC1 IGF2R	3.81e-04	14	39	2	PF00040
Domain	FN2_1	MRC1 IGF2R	3.81e-04	14	39	2	PS00023
Domain	FN2	MRC1 IGF2R	3.81e-04	14	39	2	SM00059
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	5.75e-04	78	39	3	PF14604
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	7.64e-04	86	39	3	IPR011511
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	7.64e-04	86	39	3	PF07653
Domain	FN3	RIMBP3 COL7A1 RIMBP3C RIMBP3B	7.68e-04	199	39	4	PS50853
Domain	FN3_dom	RIMBP3 COL7A1 RIMBP3C RIMBP3B	9.22e-04	209	39	4	IPR003961
Domain	Kringle-like	MRC1 IGF2R	2.03e-03	32	39	2	IPR013806
Domain	WD40	WDR27 DCAF4L2 EML4 BCAS3	2.03e-03	259	39	4	PF00400
Domain	WD40	WDR27 DCAF4L2 EML4 BCAS3	2.30e-03	268	39	4	SM00320
Domain	-	RIMBP3 HSPG2 COL7A1 RIMBP3C IGSF1 RIMBP3B	2.35e-03	663	39	6	2.60.40.10
Domain	Myb_DNA-binding	MIDEAS MYB	2.42e-03	35	39	2	PF00249
Domain	WD40_repeat	WDR27 DCAF4L2 EML4 BCAS3	2.42e-03	272	39	4	IPR001680
Domain	WD_REPEATS_1	WDR27 DCAF4L2 EML4 BCAS3	2.62e-03	278	39	4	PS00678
Domain	WD_REPEATS_2	WDR27 DCAF4L2 EML4 BCAS3	2.66e-03	279	39	4	PS50082
Domain	WD_REPEATS_REGION	WDR27 DCAF4L2 EML4 BCAS3	2.66e-03	279	39	4	PS50294
Domain	MYB_LIKE	MIDEAS MYB	2.85e-03	38	39	2	PS50090
Domain	Ig-like_fold	RIMBP3 HSPG2 COL7A1 RIMBP3C IGSF1 RIMBP3B	3.21e-03	706	39	6	IPR013783
Domain	WD40_repeat_dom	WDR27 DCAF4L2 EML4 BCAS3	3.33e-03	297	39	4	IPR017986
Domain	SANT	MIDEAS MYB	4.89e-03	50	39	2	SM00717
Domain	-	WDR27 DCAF4L2 EML4 BCAS3	4.99e-03	333	39	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR27 DCAF4L2 EML4 BCAS3	5.10e-03	335	39	4	IPR015943
Domain	SANT/Myb	MIDEAS MYB	5.27e-03	52	39	2	IPR001005
Domain	Quinoprotein_ADH-like_supfam	WDR27 EML4	5.47e-03	53	39	2	IPR011047
Domain	FN3	COL7A1 RIMBP3C RIMBP3B	6.73e-03	185	39	3	SM00060
Domain	Ig_2	HSPG2 IGSF1	1.02e-02	73	39	2	PF13895
Domain	SH3	RIMBP3 RIMBP3C RIMBP3B	1.03e-02	216	39	3	PS50002
Domain	SH3	RIMBP3 RIMBP3C RIMBP3B	1.03e-02	216	39	3	SM00326
Domain	SH3_domain	RIMBP3 RIMBP3C RIMBP3B	1.08e-02	220	39	3	IPR001452
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	8.09e-09	4	45	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	2.02e-08	5	45	3	17855024
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	7.29e-07	14	45	3	17662146
Pubmed	Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity.	COL7A1 FLG2	1.64e-06	2	45	2	34543471
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	4.91e-06	3	45	2	8643460
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	9.81e-06	4	45	2	7592911
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	1.63e-05	5	45	2	7493937
Pubmed	Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.	MRC1 IGF2R	2.45e-05	6	45	2	32234475
Pubmed	Defining the Hoxb8 cell lineage during murine definitive hematopoiesis.	MRC1 MYB	3.42e-05	7	45	2	35452096
Pubmed	Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling.	HSPG2 CLEC20A	1.47e-04	14	45	2	35677655
Pubmed	Report of the sixth international workshop on human chromosome 3 mapping 1995.	APEH COL7A1	3.38e-04	21	45	2	8641130
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	HSPG2 COL7A1	3.38e-04	21	45	2	27856617
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	BCAS3 ATG2B	4.82e-04	25	45	2	30340022
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	HSPG2 COL7A1	6.50e-04	29	45	2	22613833
Pubmed	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.	HSPG2 COL7A1	9.48e-04	35	45	2	18676816
Pubmed	Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.	DCDC1 BCAS3	1.06e-03	37	45	2	22797727
Pubmed	Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.	PTPN2 SBNO2	1.18e-03	39	45	2	19760754
Pubmed	Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.	MRC1 IGF2R	1.24e-03	40	45	2	36843585
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	HSPG2 DCAF4L2 BCAS3 MYB	1.24e-03	363	45	4	14691545
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	HSPG2 IGF2R ARSK	1.26e-03	164	45	3	32409323
Cytoband	22q11.21	RIMBP3 RIMBP3C RIMBP3B	1.81e-04	111	45	3	22q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	RIMBP3 RIMBP3C RIMBP3B IGLV4-69	7.58e-04	419	45	4	chr22q11
GeneFamily	WD repeat domain containing	WDR27 DCAF4L2 EML4 BCAS3	5.82e-04	262	27	4	362
GeneFamily	C-type lectin domain family	MRC1 CLEC20A	2.23e-03	47	27	2	494
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MIDEAS MYB	2.82e-03	53	27	2	532
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MEMO1 GPR84 ICMT FAM83A MYB	8.30e-07	176	44	5	1510cdfcfb46ce1196a1220c07fb5f3986c81b78
Disease	renal system measurement	DCDC1 BCAS3	3.02e-04	20	38	2	EFO_0004742
Disease	renal system measurement, blood urea nitrogen measurement	DCDC1 BCAS3	3.67e-04	22	38	2	EFO_0004741, EFO_0004742
Disease	Non-Small Cell Lung Carcinoma	COL7A1 XPC EML4	1.07e-03	156	38	3	C0007131
Disease	thioredoxin domain-containing protein 12 measurement	APEH COL7A1	1.16e-03	39	38	2	EFO_0008298
Disease	blood phosphate measurement	HSPG2 DCDC1 BCAS3	1.46e-03	174	38	3	EFO_0010972
Disease	heel bone mineral density, urate measurement	NPY4R2 NPY4R GLDC	1.66e-03	182	38	3	EFO_0004531, EFO_0009270
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	PTPN2 MYB	2.14e-03	53	38	2	C1961099
Disease	cardiovascular disease	DEFB112 DCDC1 BCAS3 MYB	2.76e-03	457	38	4	EFO_0000319
Disease	susceptibility to chronic sinus infection measurement	ADGRE4P NLRP4	3.49e-03	68	38	2	EFO_0008419
Disease	metabolite measurement, diet measurement	GLDC BCAS3	3.79e-03	71	38	2	EFO_0004725, EFO_0008111

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTSGHHSISNRVEAW	ARSK	131	Q6UWY0
WSTEGCSHVHSNGSY	ADGRE4P	151	Q86SQ3
WSSSQCAVHHLYTLH	BCAS3	386	Q9H6U6
GISTTYWHRLCTCTD	PKD1L1-AS1	91	Q9H7B7
AHASVWGCLATVSTH	CREG2	131	Q8IUH2
TTFHVHLWSCALDYR	ATG2B	1236	Q96BY7
RHCTSSSWSRAQLHG	HSPG2	931	P98160
ATSANITWVYSSHRH	RIMBP3B	1006	A6NNM3
ATSANITWVYSSHRH	RIMBP3C	1006	A6NJZ7
SGETRTISHFHYTTW	PTPN2	166	P17706
TCTLSSGHSSYAIAW	IGLV4-69	41	A0A075B6H9
GSQKRYHRSSCGHSW	FLG2	176	Q5D862
CHTLPRYAWQETSHD	DCDC1	1111	M0R2J8
CTESWPLAHHRTIYT	NPY4R	201	P50391
CYTRIWSLRHGHLLT	DCAF4L2	336	Q8NA75
SYSFTWLCGHVHRNI	FAM83A	256	Q86UY5
HSSTSDYSLICWHHI	NLRP4	616	Q96MN2
TCSYPGWHSTTIADH	MYB	321	P10242
FSVDTYLHLHWRTGA	GPR84	76	Q9NQS5
THTLVTSGVYAWFRH	ICMT	196	O60725
TQSHTGSYHCHSWEE	IGSF1	651	Q8N6C5
SEGHHITFSRWKSCT	DEFB112	41	Q30KQ8
SPLTSLQHCYWTSHL	CALHM4	211	Q5JW98
HSTWNCHSLSLYSAT	MIDEAS	131	Q6PJG2
RWYHRAVTGSTEACH	COL7A1	2891	Q02388
RCTGHSSYITHLDWS	EML4	716	Q9HC35
VCREASHAGSWYTAS	MEMO1	6	Q9Y316
HASSGFWSNIHCSSY	MRC1	1336	P22897
DHEWGFCRHSNSYRT	IGF2R	1936	P11717
SKEESAHWVTHTSYC	RTF2	291	Q9BY42
HRGYRTKHWSSSSAS	SRRM3	151	A6NNA2
ATSANITWVYSSHRH	RIMBP3	1006	Q9UFD9
YGWLAHCRHLSTVRT	SGSM2	501	O43147
WESGYALSLTHCSHS	SBNO2	1126	Q9Y2G9
GCLSWSHSETHLLYV	APEH	151	P13798
TILFETYRSHWHSDC	BTG4	36	Q9NY30
TYRSHWHSDCPSKGQ	BTG4	41	Q9NY30
MTWSSALLYCRSHHT	CLEC20A	171	Q6ZU45
YSHFIWATCHTGEST	ERVK-25	671	P63136
TLDHWSSRCEYLSHM	TOMT	101	Q8WZ04
CTESWPLAHHRTIYT	NPY4R2	201	P0DQD5
SSTDLRSHAWYHGRI	SH2D3C	211	Q8N5H7
VWDHCTGSLIYSSSV	WDR27	191	A2RRH5
YSRDCVHTLHSRDTW	XPC	676	Q01831
SLTCVTSSHWDRPYS	GLDC	951	P23378
SAGHAYHWPLTATCR	KIAA1958	51	Q8N8K9