Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine-type endopeptidase activity

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

5.53e-06190727GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

9.68e-06207727GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

1.13e-05212727GO:0017171
GeneOntologyMolecularFunctionendopeptidase activity

HGFAC CASP12 KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

1.55e-04430728GO:0004175
GeneOntologyCellularComponenthistone deacetylase complex

HDAC3 HDAC5 RERE SRCAP

2.36e-0485744GO:0000118
DomainWD40

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

6.38e-082597310PF00400
DomainWD40

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

8.78e-082687310SM00320
DomainWD40_repeat

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

1.01e-072727310IPR001680
DomainWD_REPEATS_1

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

1.24e-072787310PS00678
DomainWD_REPEATS_2

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

1.28e-072797310PS50082
DomainWD_REPEATS_REGION

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

1.28e-072797310PS50294
DomainTRYPSIN_SER

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

1.86e-07106737PS00135
DomainTRYPSIN_HIS

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

1.98e-07107737PS00134
DomainWD40_repeat_dom

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

2.28e-072977310IPR017986
DomainPeptidase_S1A

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

2.88e-07113737IPR001314
DomainTRYPSIN_DOM

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

3.25e-07115737PS50240
DomainTryp_SPc

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

3.66e-07117737SM00020
DomainTrypsin

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

4.60e-07121737PF00089
DomainTrypsin_dom

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

4.60e-07121737IPR001254
DomainPeptidase_S1_PA

HGFAC KLK10 PAMR1 KLK8 TMPRSS4 KLKB1 F11

5.14e-07123737IPR009003
Domain-

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

6.51e-0733373102.130.10.10
DomainWD40/YVTN_repeat-like_dom

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

6.88e-073357310IPR015943
DomainTRYPSIN_HIS

HGFAC KLK10 KLK8 TMPRSS4 KLKB1 F11

3.07e-06103736IPR018114
DomainAPPLE

KLKB1 F11

1.51e-052732SM00223
DomainAPPLE

KLKB1 F11

1.51e-052732PS00495
DomainApple

KLKB1 F11

1.51e-052732IPR000177
DomainTRYPSIN_SER

HGFAC KLK8 TMPRSS4 KLKB1 F11

2.69e-0590735IPR033116
DomainWD40_repeat_CS

TBC1D31 EML5 DPH7 EML6 WDR49 PHIP

4.38e-05164736IPR019775
DomainQuinoprotein_ADH-like_supfam

EML5 WDR6 EML6 PHIP

5.44e-0553734IPR011047
DomainSR

SSC5D CD163L1 TMPRSS4

1.24e-0425733SM00202
Domain-

SSC5D CD163L1 TMPRSS4

1.24e-04257333.10.250.10
DomainSRCR_1

SSC5D CD163L1 TMPRSS4

1.40e-0426733PS00420
DomainSRCR_2

SSC5D CD163L1 TMPRSS4

1.40e-0426733PS50287
DomainSRCR-like_dom

SSC5D CD163L1 TMPRSS4

1.40e-0426733IPR017448
DomainSRCR

SSC5D CD163L1 TMPRSS4

1.57e-0427733IPR001190
DomainHELP

EML5 EML6

2.24e-046732PF03451
DomainHELP

EML5 EML6

2.24e-046732IPR005108
DomainAnk

FEM1B ANKRD42 ASB5 PPP1R12A ASB3 ANKRD23

2.67e-04228736PF00023
DomainPAN

KLKB1 F11

3.12e-047732PS50948
DomainPan_app

KLKB1 F11

3.12e-047732IPR003609
DomainPAN_1

KLKB1 F11

3.12e-047732PF00024
DomainANK

FEM1B ANKRD42 ASB5 PPP1R12A ASB3 ANKRD23

4.45e-04251736SM00248
DomainANK_REPEAT

FEM1B ANKRD42 ASB5 PPP1R12A ASB3 ANKRD23

4.64e-04253736PS50088
DomainAnkyrin_rpt-contain_dom

FEM1B ANKRD42 ASB5 PPP1R12A ASB3 ANKRD23

4.74e-04254736IPR020683
DomainANK_REP_REGION

FEM1B ANKRD42 ASB5 PPP1R12A ASB3 ANKRD23

4.74e-04254736PS50297
DomainAnkyrin_rpt

FEM1B ANKRD42 ASB5 PPP1R12A ASB3 ANKRD23

5.58e-04262736IPR002110
DomainHist_deacetyl

HDAC3 HDAC5

8.10e-0411732PF00850
DomainHis_deacetylse_dom

HDAC3 HDAC5

8.10e-0411732IPR023801
Domain-

HDAC3 HDAC5

8.10e-04117323.40.800.20
DomainHis_deacetylse

HDAC3 HDAC5

8.10e-0411732IPR000286
DomainCUB

PAMR1 ATRNL1 CDCP2

9.28e-0449733PF00431
DomainCUB

PAMR1 ATRNL1 CDCP2

9.84e-0450733SM00042
Domain-

PAMR1 ATRNL1 CDCP2

1.10e-03527332.60.120.290
DomainCUB

PAMR1 ATRNL1 CDCP2

1.17e-0353733PS01180
DomainCUB_dom

PAMR1 ATRNL1 CDCP2

1.44e-0357733IPR000859
DomainAnk_2

FEM1B ANKRD42 ASB5 PPP1R12A ANKRD23

1.54e-03215735PF12796
DomainLH2

LOXHD1 ALOX15

2.21e-0318732SM00308
DomainEGF

HGFAC PAMR1 ATRNL1 LAMA2 NPNT

2.27e-03235735SM00181
DomainApc4_WD40_dom

EML5 EML6

2.74e-0320732IPR024977
DomainANAPC4_WD40

EML5 EML6

2.74e-0320732PF12894
Domain-

FEM1B ANKRD42 ASB5 PPP1R12A ANKRD23

2.86e-032487351.25.40.20
DomainEGF-like_dom

HGFAC PAMR1 ATRNL1 LAMA2 NPNT

2.91e-03249735IPR000742
DomainPLAT

LOXHD1 ALOX15

3.02e-0321732PS50095
Domain-

LOXHD1 ALOX15

3.02e-03217322.60.60.20
DomainSRCR

SSC5D CD163L1

3.02e-0321732PF00530
DomainPLAT

LOXHD1 ALOX15

3.02e-0321732PF01477
DomainPLAT/LH2_dom

LOXHD1 ALOX15

3.02e-0321732IPR001024
DomainEGF_1

HGFAC PAMR1 ATRNL1 LAMA2 NPNT

3.22e-03255735PS00022
DomainEGF-like_CS

HGFAC PAMR1 ATRNL1 LAMA2 NPNT

3.56e-03261735IPR013032
DomainEGF_2

HGFAC PAMR1 ATRNL1 LAMA2 NPNT

3.79e-03265735PS01186
Domain-

CASP12 TNFRSF10A NLRP3

5.78e-03937331.10.533.10
DomainEGF_LAM_2

ATRNL1 LAMA2

6.11e-0330732PS50027
DomainEGF_LAM_1

ATRNL1 LAMA2

6.11e-0330732PS01248
DomainDEATH-like_dom

CASP12 TNFRSF10A NLRP3

6.87e-0399733IPR011029
Pubmed

Identification of Restriction Factors by Human Genome-Wide RNA Interference Screening of Viral Host Range Mutants Exemplified by Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus K1L-C7L- Mutant.

SAMD9 WDR6

4.47e-06274226242627
Pubmed

The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.

SRPK1 SRPK2

4.47e-06274232817937
Pubmed

Serine-arginine protein kinases: a small protein kinase family with a large cellular presence.

SRPK1 SRPK2

4.47e-06274221205200
Pubmed

Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.

SRPK1 SRPK2

4.47e-06274212134018
Pubmed

Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles.

SRPK1 SRPK2

4.47e-0627429446799
Pubmed

The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells.

KLKB1 F11

4.47e-06274212944405
Pubmed

Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase.

SRPK1 SRPK2

4.47e-06274220498328
Pubmed

Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340).

SRPK1 SRPK2

4.47e-06274226244849
Pubmed

Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen.

KLKB1 F11

4.47e-06274228124063
Pubmed

Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.

SRPK1 SRPK2

4.47e-06274216122776
Pubmed

Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.

KLKB1 F11

4.47e-0627423636155
Pubmed

Activation of the zymogen of hepatocyte growth factor activator by thrombin.

HGFAC KLKB1

1.34e-0537428226803
Pubmed

METTL3-deficiency m6A-dependently degrades MALAT1 to suppress NLRP3-mediated pyroptotic cell death and inflammation in Mycobacterium tuberculosis (H37Ra strain)-infected mouse macrophages.

METTL3 NLRP3

1.34e-05374238458103
Pubmed

Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway.

SRPK1 SRPK2

1.34e-05374212417631
Pubmed

Hageman-factor-dependent fibrinolysis: generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen.

KLKB1 F11

1.34e-05374289876
Pubmed

Antigen levels of coagulation factor XII, coagulation factor XI and prekallikrein, and the risk of myocardial infarction and ischemic stroke in young women.

KLKB1 F11

1.34e-05374224977287
Pubmed

HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy.

HDAC5 NLRP3

1.34e-05374236183679
Pubmed

Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain.

KLKB1 F11

1.34e-053742291905
Pubmed

SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.

SRPK1 SRPK2

1.34e-05374223197718
Pubmed

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain.

KLKB1 F11

1.34e-05374230591525
Pubmed

Genetic variants associated with deep vein thrombosis: the F11 locus.

KLKB1 F11

1.34e-05374219583818
Pubmed

Histone deacetylase 3 associates with and represses the transcription factor GATA-2.

HDAC3 HDAC5

1.34e-05374211567998
Pubmed

Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes.

CASP12 NLRP3

1.34e-05374232788872
Pubmed

The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs).

SRPK1 SRPK2

1.34e-05374210196197
Pubmed

LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease.

HDAC3 HDAC5

2.67e-05474234119632
Pubmed

Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor.

KLKB1 F11

2.67e-0547428555184
Pubmed

Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy.

HDAC3 HDAC5

2.67e-05474223615070
Pubmed

Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.

SRPK1 SRPK2

2.67e-05474228076779
Pubmed

Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5.

HDAC3 HDAC5

2.67e-05474210655483
Pubmed

WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.

WDR6 WDR49

2.67e-05474211814058
Pubmed

Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.

CASP12 NLRP3

2.67e-05474226582949
Pubmed

HDAC1/3-dependent moderate liquid-liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation.

HDAC3 METTL3

2.67e-05474236424383
Pubmed

Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity.

KLK10 KLK8

2.67e-05474219085836
Pubmed

SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.

SRPK1 SRPK2

2.67e-05474233602301
Pubmed

Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.

KLKB1 F11

2.67e-0547422844223
Pubmed

METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance.

METTL3 HDAC5

2.67e-05474236257380
Pubmed

Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.

SRPK1 SRPK2 SRPK3

3.98e-053174316140986
Pubmed

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.

HDAC3 HDAC5

4.45e-05574210983972
Pubmed

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.

CASP12 NLRP3

4.45e-05574220818395
Pubmed

Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease.

KLKB1 F11

4.45e-05574210962009
Pubmed

Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.

HDAC3 HDAC5

4.45e-05574215194749
Pubmed

Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa.

KLKB1 F11

4.45e-05574212372819
Pubmed

Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A.

SRPK1 SRPK2

4.45e-05574212565863
Pubmed

Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy.

HDAC3 HDAC5

4.45e-05574223624624
Pubmed

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.

SRPK1 SRPK2

4.45e-05574221157427
Pubmed

The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis.

KLKB1 F11

4.45e-05574226153520
Pubmed

The histone deacetylase-3 complex contains nuclear receptor corepressors.

HDAC3 HDAC5

4.45e-05574210860984
Pubmed

Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation.

HDAC3 HDAC5

4.45e-05574222730529
Pubmed

Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation.

HDAC3 HDAC5

4.45e-05574214668799
Pubmed

Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome.

SFTPB GYS1

6.66e-05674233219378
Pubmed

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

NLRP3 ALOX15

6.66e-05674223809162
Pubmed

TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.

HDAC3 HDAC5

6.66e-05674218245468
Pubmed

Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.

HDAC3 HDAC5

6.66e-05674217873065
Pubmed

The balance between acetylation and deacetylation controls Smad7 stability.

HDAC3 HDAC5

6.66e-05674215831498
Pubmed

Histone deacetylase 3 binds to and regulates the GCMa transcription factor.

HDAC3 HDAC5

6.66e-05674216528103
Pubmed

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

DCAF12L1 DCAF12L2 PHIP

6.82e-053774316949367
Pubmed

Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.

HDAC3 RERE

9.31e-05774216481466
Pubmed

Purification and characterization of plasma protein C inhibitor.

KLKB1 F11

9.31e-0577422551064
Pubmed

Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.

KLK10 KLK8

9.31e-05774210969073
Pubmed

Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.

HDAC3 HDAC5

9.31e-05774211022042
Pubmed

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.

HDAC3 HDAC5

9.31e-05774211804585
Pubmed

m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome.

METTL3 NLRP3

9.31e-05774236461592
Pubmed

A serine kinase regulates intracellular localization of splicing factors in the cell cycle.

SRPK1 SRPK2

9.31e-0577428208298
Pubmed

Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion.

HDAC3 HDAC5

9.31e-05774223867755
Pubmed

Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow.

HDAC3 HDAC5

9.31e-05774222308472
Pubmed

Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.

HDAC3 HDAC5

9.31e-05774217075044
Pubmed

HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF.

HDAC3 HDAC5

9.31e-05774215467736
Pubmed

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.

HDAC3 HDAC5

9.31e-05774210869435
Pubmed

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.

HDAC3 HDAC5

1.59e-04974211466315
Pubmed

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.

HDAC3 HDAC5

1.59e-04974215367668
Pubmed

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

HDAC3 HDAC5

1.59e-04974212150997
Pubmed

The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.

HDAC3 HDAC5

1.59e-04974222989952
Pubmed

Identification of a nuclear domain with deacetylase activity.

HDAC3 HDAC5

1.59e-04974210984530
Pubmed

Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators.

HDAC3 HDAC5

1.59e-04974215184363
Pubmed

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.

HDAC3 HDAC5

1.59e-04974211641275
Pubmed

Class II histone deacetylases: versatile regulators.

HDAC3 HDAC5

1.99e-041074212711221
Pubmed

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.

NLRP3 ALOX15

1.99e-041074219734227
Pubmed

BCoR, a novel corepressor involved in BCL-6 repression.

HDAC3 HDAC5

1.99e-041074210898795
Pubmed

Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.

KLK10 KLK8

1.99e-041074219558318
Pubmed

Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes.

SRPK1 SRPK2

1.99e-041074210198174
Pubmed

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.

HDAC3 HDAC5

1.99e-041074215619633
Pubmed

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

HDAC3 HDAC5

1.99e-041074211931768
Pubmed

Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.

HDAC3 HDAC5

1.99e-041074228028172
Pubmed

Functional analysis of Asb-1 using genetic modification in mice.

ASB5 ASB3

2.43e-041174211509662
Pubmed

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

HDAC3 HDAC5

2.43e-041174222649097
Pubmed

SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.

SRPK1 SRPK2

2.43e-04117429472028
Pubmed

Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.

HDAC3 HDAC5

2.91e-041274215140878
Pubmed

Histone deacetylase 1 and p300 can directly associate with chromatin and compete for binding in a mutually exclusive manner.

HDAC3 HDAC5

2.91e-041274224722339
Pubmed

Human tissue kallikreins: physiologic roles and applications in cancer.

KLK10 KLK8

3.43e-041374215192120
Pubmed

A molecular dissection of the repression circuitry of Ikaros.

HDAC3 HDAC5

4.00e-041474212015313
Pubmed

Histone deacetylase expression patterns in developing murine optic nerve.

HDAC3 HDAC5

4.00e-041474225011550
Pubmed

Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains.

KLK10 KLK8

4.00e-041474225666037
Pubmed

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.

HDAC3 HDAC5

4.00e-041474215601857
Pubmed

Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

KLK10 KLK8

4.00e-041474211054574
Pubmed

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.

HDAC3 HDAC5

4.00e-041474215537544
Pubmed

Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.

ABLIM1 PPP1R12A

4.00e-041474215570572
Pubmed

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.

KLK10 KLK8

4.61e-041574215203212
Pubmed

Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005.

KLK10 KLK8

4.61e-041574216800723
Pubmed

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.

KLK10 KLK8

4.61e-041574216800724
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SAMD9 WDR6 ASB3 SRPK1 SRPK2 IFT122 CMTR2

4.70e-0465074738777146
Cytoband4q35

KLKB1 F11

2.65e-04157424q35
GeneFamilyWD repeat domain containing

TBC1D31 EML5 DCAF12L1 DPH7 WDR6 EML6 IFT122 DCAF12L2 WDR49 PHIP

4.70e-092625410362
GeneFamilyKallikreins

KLK10 KLK8 KLKB1

1.37e-0516543616
GeneFamilyAnkyrin repeat domain containing

FEM1B ANKRD42 ASB5 PPP1R12A ASB3 ANKRD23

8.16e-05242546403
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SSC5D CD163L1

2.93e-03275421253
GeneFamilyMethyltransferase like

METTL3 ETFBKMT

4.36e-0333542963
GeneFamilyZinc fingers CCCH-type

ZGPAT UNKL

4.89e-033554273
CoexpressionGSE9650_NAIVE_VS_EXHAUSTED_CD8_TCELL_UP

ABLIM1 HDAC5 EML5 KLK8 SRPK1 RERE SRCAP

1.58e-06200747M5821
CoexpressionKAECH_NAIVE_VS_DAY15_EFF_CD8_TCELL_UP

ABLIM1 METTL3 HDAC5 EML5 WDR6 KLK8 SRCAP

1.58e-06200747M3014
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BNC2 SSC5D PAMR1 NPTXR LAMA2 NPNT

5.76e-07181746b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

SFTPB TMPRSS4 DLEC1 WDR49 ALOX15

5.33e-061517458216462e723fec2797387929dde095370947e10a
ToppCellIonocyte|World / shred by cell class for nasal brushing

BNC2 SFTPB ASB5 ZFP57 SRPK3

5.86e-061547456b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

BNC2 SSC5D PAMR1 ATRNL1 LAMA2

1.03e-051737451f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SSC5D NPTXR LAMA2 DLEC1 CREB3L1

1.03e-05173745ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_progenitors|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KLK10 SFTPB TMPRSS4 WDR49 NPNT

1.39e-05184745fcb5dd4fb3fa79f3b6029fad32a474cacde35a3b
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D PAMR1 ATRNL1 LAMA2

1.43e-051857453b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

BNC2 SSC5D PAMR1 ATRNL1 LAMA2

1.58e-0518974544e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BNC2 PAMR1 MARCHF3 LAMA2 CREB3L1

1.62e-051907450fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BNC2 PAMR1 MARCHF3 CREB3L1 CDON

1.62e-051907454f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BNC2 PAMR1 LAMA2 CREB3L1 CDON

1.70e-051927458d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BNC2 PAMR1 MARCHF3 CREB3L1 CDON

1.75e-05193745cd45118ced91b10baed3b1068d4673ec99824b86
ToppCellCOPD-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

ABLIM1 PAMR1 MARCHF3 LAMA2 CDON

1.88e-051967454930eeb303d174c28fd91021723e26fdf1af9170
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3|Hippocampus / BrainAtlas - Mouse McCarroll V32

KLK10 LOXHD1 NPTXR KLK8

5.98e-051277449bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

BNC2 EML6 TNFRSF10A KLKB1

1.29e-04155744c4dc0fa1d0e657753a56939eb4829fb60382c17f
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD163L1 CLDND2 ZFP57 NPNT

1.39e-0415874412661763d1c309106801cb710c04cd2b62d16cba
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD163L1 CLDND2 ZFP57 NPNT

1.39e-04158744e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD163L1 CLDND2 ZFP57 NPNT

1.39e-041587440792c39e6fc0745095af7812de2d50949540d60f
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD163L1 TMEM39B NLRP3 ALOX15

1.57e-041637447af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

BNC2 SSC5D ASB5 ATRNL1

1.61e-04164744e3983f655cdba308fb192182829f17bef99ce0ba
ToppCellCOVID-19-lung-Mesothelial|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATRNL1 DLEC1 ALOX15 CDON

1.61e-0416474483303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CACNG6 DLEC1 WDR49 NPNT

1.64e-041657440c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CACNG6 DLEC1 WDR49 NPNT

1.64e-0416574482530f96aaefe28a13bad0474bbad043f127a86c
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

KLK10 PAMR1 KLK8 ALOX15

1.68e-041667441ed3788257e14f097862b999f020bfe2a57de52b
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM1 WDR6 KLK8 SARDH

1.76e-04168744182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM1 CLDND2 KLK8 DLEC1

1.80e-0416974418ba8fc2ba8838484d3b223428cd41568e2ccb10
ToppCelldroplet-Lung-nan-21m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM1 CLDND2 KLK8 DLEC1

1.80e-0416974447a63afd80cb7ba2258ba57d3084d8b2a7bc4e8d
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM1 ASB5 PPP1R12A KLK8

1.84e-04170744aff226a84e397ab58204325aa9d8b396a881986e
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM1 ASB5 PPP1R12A KLK8

1.84e-041707446af16e6f276aec6389ece99505ba13c7edc4c4fa
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

KLK10 ATRNL1 KLK8 ALOX15

1.97e-04173744e05cddf5bf63cf419343ff229453327519765be8
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

KLK10 ATRNL1 KLK8 ALOX15

1.97e-0417374474ad5ed33821b8816c9c8e67c50ee4496ba18e2f
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BNC2 PAMR1 DCAF12L2 CDON

1.97e-0417374430d67738633493d47f06ae452424382f069b6c0a
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

UNKL ANKRD23 SRCAP NLRP3

2.01e-04174744a1f745962a104c6f4b86b7e482da8755384c773a
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BNC2 PAMR1 DCAF12L2 CDON

2.01e-04174744a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BNC2 SYNJ1 PAMR1 CDON

2.01e-041747444da79da7a09ee1e345102c5331675ebcdbe56171
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

UNKL ANKRD23 SRCAP NLRP3

2.06e-0417574478a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCellnormal_Lung-Fibroblasts-Mesothelial_cells|normal_Lung / Location, Cell class and cell subclass

ATRNL1 KLK8 ALOX15 CDON

2.10e-04176744f31d7234053085a82cf9d55aeedd1e04d34789c3
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

BNC2 SSC5D ATRNL1 LAMA2

2.15e-04177744b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

ABLIM1 HDAC5 TNFRSF10A PCDH12

2.15e-04177744c9f269765c7d5d29caab75910e51645606ed562e
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BNC2 PAMR1 KLK8 ALOX15

2.15e-041777440912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D PAMR1 ATRNL1

2.24e-0417974402c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

BNC2 SFTPB ASB5 SRPK3

2.29e-041807448af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCellCiliated_cells-A-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

KLK10 TMPRSS4 DLEC1 ALOX15

2.29e-04180744d9be152773fe9f2160edad9246fa03c03afeafd6
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

BNC2 PAMR1 ATRNL1 LAMA2

2.29e-0418074401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABLIM1 CD163L1 KLK8 SRPK1

2.34e-041817446a32eb83aa39484ca43c91e6b58302d8dea84b7e
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BNC2 DCAF12L1 PAMR1 CDON

2.39e-041827449966f42c338cbd471efa8ffc765a6ce93693aa75
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D PAMR1 ATRNL1

2.44e-041837447eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D ATRNL1 LAMA2

2.44e-0418374412daaea821e49bc94a01e2496331e92a80d27339
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BNC2 PAMR1 CREB3L1 NPNT

2.44e-04183744274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCellwk_20-22-Mesenchymal-Mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KLK10 KLK8 ALOX15 CDON

2.49e-04184744804f8a41cd6b1361448872bf352bf0a38a0fac66
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BNC2 PAMR1 CREB3L1 CDON

2.49e-04184744607b55022de21ddb6a2d75e085df76df7abf6624
ToppCellwk_20-22-Mesenchymal-Mesothelial-Late_mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KLK10 KLK8 ALOX15 CDON

2.49e-0418474460dd055c2e2e92b838ac649c12e8cccd9c3b1b71
ToppCelltumor_Lung-Fibroblasts-Mesothelial_cells|tumor_Lung / Location, Cell class and cell subclass

BNC2 KLK8 ALOX15 CDON

2.49e-04184744b0a251030d127858e68cf164be158f209a4d720f
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D PAMR1 LAMA2 CREB3L1

2.54e-041857443cd0686a14e734a0f243070ab939adcb4c454478
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D PAMR1 LAMA2 CREB3L1

2.54e-0418574400258f458cbf6d36449db95528a6b5038d731d2d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D PAMR1 LAMA2 CREB3L1

2.54e-04185744a94694e226856bc5b168464f52d76004145717a5
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

BNC2 SSC5D PAMR1 LAMA2

2.54e-04185744fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

BNC2 PAMR1 MARCHF3 LAMA2

2.54e-04185744a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BNC2 SSC5D LAMA2 NPNT

2.54e-041857449f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KLK10 KLK8 ALOX15 CDON

2.54e-04185744492529121cb9e88bd3c0db6b54af3cd2979572bc
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D PAMR1 ATRNL1

2.54e-04185744e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC CLDND2 KLK8

2.55e-04747430288a3f4eafbc359d01cde4ba58f946dd07c77cb
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC CLDND2 KLK8

2.55e-047474357884ade66fe39398351685189df5efd7aea0aab
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC CLDND2 KLK8

2.55e-047474313093139a75bfe11f6b032c9fb402efcc703551c
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-Inhba_(CA3_Principal_cells)|Hippocampus / BrainAtlas - Mouse McCarroll V32

KLK10 SFTPB LDHAL6B

2.55e-047474329d94713d97ac44e0f83d2f3609a719650e20d0f
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC CLDND2 KLK8

2.55e-04747437f7de9e8142d2435391ee965cee5628e412f0705
ToppCell21-Trachea-Epithelial-Goblet-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

KLK10 SFTPB ZNF552 CREB3L1

2.60e-04186744f8cddad28896f0edf10a8645fa49a011b22b120d
ToppCellwk_15-18-Mesenchymal-Mesothelial-Late_mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KLK10 KLK8 ALOX15 CDON

2.70e-0418874438a53f99f1876359983936403aefca93281d10fd
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D PAMR1 ATRNL1

2.70e-041887443177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KLK10 KLK8 ALOX15 CDON

2.70e-041887449655a4c47b644a870017d349b99063e17dbae572
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABLIM1 KLK10 TMPRSS4 CREB3L1

2.70e-041887445901b276f2379abf486b8285957277e95f08464e
ToppCell(2)_Fibroblasts-(20)_Fibro-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

BNC2 SSC5D ABLIM1 LAMA2

2.70e-04188744409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BNC2 ASB5 ATRNL1 NPNT

2.76e-04189744ab7ece0a517499b70b7754720d3e434765363af6
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

BNC2 SFTPB ASB5 SRPK3

2.76e-041897446011b747e27d61d222380a7bffdd921a68e9b657
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D PAMR1 ATRNL1

2.76e-0418974445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATRNL1 SRPK3 CDON NPNT

2.81e-04190744e102622f05c7f3e1bd8b224ea159d57033793ee0
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D LAMA2 DCAF12L2 CREB3L1

2.81e-04190744f61e21d53f2f7804ac6e40ab6c7f69838aa94d6a
ToppCelldroplet-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D LAMA2 DCAF12L2 CREB3L1

2.81e-041907442abeb013bb83c578e67dcb985ba44ca63134950b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 PAMR1 ATRNL1 LAMA2

2.81e-041907442306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP12 LAMA2 CREB3L1 CDON

2.81e-04190744947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 PAMR1 ATRNL1 LAMA2

2.81e-041907441f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCellBL-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KLK10 KLK8 TMPRSS4 CREB3L1

2.81e-04190744f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCell15-Distal-Mesenchymal-Mesenchyme_SERPINF1-high|Distal / Age, Tissue, Lineage and Cell class

BNC2 PAMR1 SRPK3 CREB3L1

2.81e-04190744b47472dc9fe6ed99c2365203a3d8a59879e74a70
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 PAMR1 ATRNL1 LAMA2

2.87e-04191744a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATRNL1 PPP1R12A SRPK3 CDON

2.87e-04191744de2cd94ee88a7754f86d39469e38374d668210c7
ToppCellwk_15-18-Mesenchymal-Mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KLK10 KLK8 ALOX15 CDON

2.87e-04191744b5374674312ff5803a1d369f5533027532344679
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-fibroblast|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP12 PAMR1 ALOX15 CDON

2.87e-041917449214655dca96d766737c9f30b624d7fe7050342e
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

KLK10 SFTPB TMPRSS4 NPNT

2.87e-0419174423776c7302cead3881b39127398f3b3e0d27885e
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

KLK10 SFTPB TMPRSS4 NPNT

2.87e-041917443c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellfacs-Trachea-nan-18m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM1 PAMR1 LAMA2 CDON

2.87e-04191744783e8c436de90623bb1bc4117270d60c8c8a9461
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BNC2 PAMR1 CREB3L1 CDON

2.87e-04191744156b467187331ac6ca390d6ca861d9670bb7b956
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 SSC5D PAMR1 ATRNL1

2.87e-04191744b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 PAMR1 ATRNL1 LAMA2

2.93e-041927449093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PAMR1 LAMA2 DCAF12L2 CDON

2.93e-041927444ed5040594ba2d0639f0990697504ecef872ca70
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BNC2 LAMA2 CREB3L1 CDON

2.93e-04192744c3707243c5590d852c9f28429c96f50a1fa6b0dc
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PAMR1 LAMA2 DCAF12L2 CDON

2.93e-04192744d4f5d6653564c2c5d0f5f7c932d89cb1b1412844
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

KLK10 SFTPB TMPRSS4 NPNT

2.93e-04192744d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 PAMR1 ATRNL1 LAMA2

2.93e-041927449ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D PAMR1 LAMA2 CREB3L1

2.93e-04192744beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell18-Distal-Epithelial-Secretory_progenitor|Distal / Age, Tissue, Lineage and Cell class

KLK10 SFTPB TMPRSS4 SRCAP

2.93e-041927449fae988ecd2ef1231bfd42a678a4903517694cbe
Diseasekallikrein-8 measurement

KLK10 KLK8

8.51e-056712EFO_0020516
Diseaseage-related hearing impairment

BNC2 SAMD9 LOXHD1 ASB3 TMPRSS4 DLEC1

1.32e-04324716EFO_0005782
Diseasefactor XI measurement

KLKB1 F11

1.58e-048712EFO_0004694
Diseasekallikrein-11 measurement

KLK10 KLK8

2.03e-049712EFO_0010573
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

HGFAC F11 NLRP3

3.38e-0456713EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Diseasevenous thromboembolism, fibrinogen measurement

HGFAC F11 NLRP3

5.73e-0467713EFO_0004286, EFO_0004623
DiseaseHoloprosencephaly

PPP1R12A CDON

7.58e-0417712C0079541
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

ANKRD42 ATRNL1 ASB3

1.27e-0388713EFO_0803332
Diseasepartial thromboplastin time

KLKB1 F11

1.52e-0324712EFO_0004310
Diseaseaggressive behavior

SAMD9 F11

1.65e-0325712EFO_0003015
Diseasebrain ischemia (biomarker_via_orthology)

CASP12 NPTXR ALOX15

1.93e-03102713DOID:2316 (biomarker_via_orthology)
Diseaseglomerular filtration rate, response to platinum based chemotherapy

MARCHF3 RERE

2.07e-0328712EFO_0004647, EFO_0005208
Diseasecongestive heart failure (biomarker_via_orthology)

CASP12 NPTXR ALOX15

2.22e-03107713DOID:6000 (biomarker_via_orthology)
Diseasefibrinogen measurement

HGFAC PHIP NLRP3

2.34e-03109713EFO_0004623
Diseasefactor XI measurement, venous thromboembolism

CREB3L1 F11

2.38e-0330712EFO_0004286, EFO_0004694

Protein segments in the cluster

PeptideGeneStartEntry
DAEHGAWALGHKLCS

CREB3L1

111

Q96BA8
TALHWACLKGHSQLV

ANKRD23

146

Q86SG2
GQALLALDKQWHLGC

ABLIM1

236

O14639
QCKHGWVAHALDKLS

BNC2

136

Q6ZN30
CHWVIRAAGPAHVKL

CDCP2

171

Q5VXM1
SEEAPLLGNWCGHHL

CDCP2

326

Q5VXM1
HLGRVGCWALHFLLD

GPR31

81

O00270
ASNLECHLWHILEGK

CMTR2

486

Q8IYT2
ELKIQGRWGTVCHHK

CD163L1

276

Q9NR16
SHSILNGICGTKHWD

CASP12

171

Q6UXS9
NGSAVCEAAHLGLWK

CACNG6

71

Q9BXT2
KAAGQGHIECLQWLI

ANKRD42

276

Q8N9B4
HGGLKGVAHLWQEFV

RAB3GAP1

471

Q15042
LDSGHNGLVHCWLSQ

PCDH12

381

Q9NPG4
NGLVHCWLSQELGHF

PCDH12

386

Q9NPG4
EHVKAIEICGDHGWV

IFT122

776

Q9HBG6
HGLCGWIREKDNDLH

NPNT

426

Q6UXI9
GHLCKLRVWHDNKGI

LOXHD1

1741

Q8IVV2
CLGDRHGHKDWIFAV

DCAF12L2

186

Q5VW00
ALWCAAGAGHFEVVK

FEM1B

91

Q9UK73
GLLWGQLTHALACRH

C9orf131

16

Q5VYM1
KLGIHSESCHGWILG

LDHAL6B

226

Q9BYZ2
GQWAGAKLLDHGCVE

GHDC

411

Q8N2G8
CTGQHASVHLGQLDW

ALOX15

536

P16050
VPGHLCDGQWHKVTA

LAMA2

3016

P24043
LAHCHGAVLGTSWQL

MON2

686

Q7Z3U7
CLHHDQGLTELAWGT

KIF25-AS1

31

Q9Y6Z4
AGHKCQIAGWGHLDE

HGFAC

531

Q04756
PLSLKDNGWHHICIA

NPTXR

371

O95502
KICDIAINWAGGLHH

HDAC3

121

O15379
RTGHWLNHGKEHCLV

METTL3

471

Q86U44
HECLGCIWGQGHLKG

RGL4

241

Q8IZJ4
CIWGQGHLKGNEHMA

RGL4

246

Q8IZJ4
CALHLAASQGHWKIV

ASB3

81

Q9Y575
WCHIPVAGHALLGLA

DPH7

96

Q9BTV6
LLGHHGLASAKFLWC

GUCY2F

21

P51841
WLHNGKTLDGNLEHV

CDON

61

Q4KMG0
GGPLSCKHNEVWHLV

F11

576

P03951
ASKGHHECLDILISW

ASB5

176

Q8WWX0
QALPAHLCGEGWSHI

ATRNL1

741

Q5VV63
ISGWLCLRGAVDHLH

MARCHF3

161

Q86UD3
VLVGGNWVLTAAHCK

KLK8

61

O60259
GSLIGHQWVLTAAHC

KLKB1

421

P03952
CLGDRHGHKDWIFAV

DCAF12L1

186

Q5VU92
HKAHWAVSAGVLLGV

C19orf54

231

Q5BKX5
QGHCEGELWALAVHP

EML5

321

Q05BV3
QGHCEGELWALALHP

EML6

321

Q6ZMW3
GWKAHRNHCGLLLQA

ETFBKMT

6

Q8IXQ9
VGKVLIVDWDIHHGN

HDAC5

861

Q9UQL6
VAHFHEWLAGVGLCL

GYS1

176

P13807
QFHWGKLLGHQAEFC

DLEC1

1001

Q9Y238
LNAHCEWTIHAKPGF

PAMR1

146

Q6UXH9
HDGSLHKGAWFLVCS

PAMR1

476

Q6UXH9
GSQEHGLCAHLWGLC

NLRP3

456

Q96P20
GPWLGQLQELLHHCD

RSAD1

206

Q9HA92
AGGKSNHLHLWCLEA

TBC1D31

231

Q96DN5
ALGHCLQEVWGHVGA

SFTPB

51

P07988
LHLKHYGVNCDDWLL

SYNJ1

166

O43426
ICVHPHIFQGWKDLL

SAMD9

576

Q5K651
VEHILWHVGLSACLG

PIGQ

366

Q9BRB3
KDWHHGGRENILLCT

RERE

516

Q9P2R6
ADLGNACWVHKHFTE

SRPK1

496

Q96SB4
LLAHLACEKGNWGPH

SRCAP

656

Q6ZRS2
PWGKHNCAHNEDVGV

SSC5D

551

A1L4H1
LGGGCGQELAHWIIH

SARDH

416

Q9UL12
KIADLGNACWVHKHF

SRPK3

406

Q9UPE1
EGHSGLWQECNHGIC

CLDND2

36

Q8NHS1
SSHHKCRVILGQWLG

ZFP57

386

Q9NU63
KHVVWKGSALAALHC

PHIP

116

Q8WWQ0
VKIADLGNACWVHKH

SRPK2

526

P78362
LGNACWVHKHFTEDI

SRPK2

531

P78362
WKGGIQHHDDILCAA

WDR49

276

Q8IV35
KQHVCGGSILDPHWV

TMPRSS4

226

Q9NRS4
EKLHIVNCGGGHRSW

WDR6

646

Q9NNW5
HKESGNGHNIWVILV

TNFRSF10A

231

O00220
SLGMVNEWGCHDLHL

UNKL

311

Q9H9P5
GTHHKQKLHRCEAWG

ZNF552

111

Q9H707
GSACLAKHQDGLWHA

ZGPAT

221

Q8N5A5
LLHKAAAHLGCWQKV

TMEM39B

346

Q9GZU3
HCGNKPLWARVGDDH

KLK10

86

O43240
LHAAAHWGKEEACRI

PPP1R12A

236

O14974