Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	intraciliary transport particle A	WDR19 IFT140	1.88e-04	8	55	2	GO:0030991
MousePheno	absent lens vesicle	MAB21L2 MAB21L1	2.39e-05	3	40	2	MP:0009725
MousePheno	abnormal macrophage apoptosis	GSDMD PELI2 FAS	4.78e-05	25	40	3	MP:0011073
Domain	WD40_repeat_dom	WDR19 IFT140 NWD1 TAF1C GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	9.48e-09	297	53	10	IPR017986
Domain	-	WDR19 IFT140 NWD1 TAF1C GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	2.80e-08	333	53	10	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR19 IFT140 NWD1 TAF1C GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	2.97e-08	335	53	10	IPR015943
Domain	WD40	WDR19 IFT140 NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	4.30e-08	259	53	9	PF00400
Domain	WD40	WDR19 IFT140 NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	5.76e-08	268	53	9	SM00320
Domain	WD40_repeat	WDR19 IFT140 NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	6.54e-08	272	53	9	IPR001680
Domain	WD_REPEATS_1	WDR19 IFT140 NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	7.88e-08	278	53	9	PS00678
Domain	WD_REPEATS_2	WDR19 IFT140 NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	8.12e-08	279	53	9	PS50082
Domain	WD_REPEATS_REGION	WDR19 IFT140 NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	8.12e-08	279	53	9	PS50294
Domain	WD40_repeat_CS	NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDR47	6.82e-06	164	53	6	IPR019775
Domain	Mab-21-like_1/2	MAB21L2 MAB21L1	7.86e-05	5	53	2	IPR020950
Domain	Chond_GalNAc	CHPF2 B4GALNT3	2.19e-04	8	53	2	IPR008428
Domain	CHGN	CHPF2 B4GALNT3	2.19e-04	8	53	2	PF05679
Domain	LRRcap	LRRC56 NXF1	4.27e-04	11	53	2	SM00446
Domain	U2A'_phosphoprotein32A_C	LRRC56 NXF1	4.27e-04	11	53	2	IPR003603
Domain	Mab-21	MAB21L2 MAB21L1	5.12e-04	12	53	2	PF03281
Domain	Mab-21	MAB21L2 MAB21L1	5.12e-04	12	53	2	SM01265
Domain	Mab-21_dom	MAB21L2 MAB21L1	5.12e-04	12	53	2	IPR024810
Domain	Apc4_WD40_dom	NWD1 WDR47	1.45e-03	20	53	2	IPR024977
Domain	ANAPC4_WD40	NWD1 WDR47	1.45e-03	20	53	2	PF12894
Domain	LRR	IGFALS LRRC56 LRRC61 NXF1	2.53e-03	201	53	4	PS51450
Domain	LRR_1	IGFALS LRRC56 LRRC61 NXF1	3.44e-03	219	53	4	PF00560
Pubmed	Genomic cloning and chromosomal localization of the mouse Mab21l2 locus.	MAB21L2 MAB21L1	2.55e-06	2	56	2	10516425
Pubmed	The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.	MAB21L2 MAB21L1	2.55e-06	2	56	2	27558071
Pubmed	Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation.	MAB21L2 MAB21L1	2.55e-06	2	56	2	11857508
Pubmed	Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.	DNHD1 ARHGEF40 TNKS1BP1	2.65e-06	17	56	3	12693554
Pubmed	Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous.	IGKV1-33 IGKV1D-33	7.63e-06	3	56	2	1940382
Pubmed	MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode.	MAB21L2 MAB21L1	2.54e-05	5	56	2	34779479
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	WDR90 PAK1IP1 WDTC1	3.74e-05	40	56	3	25011449
Pubmed	WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.	IFT140 WDTC1 WDR47	3.74e-05	40	56	3	29078390
Pubmed	Cranioectodermal Dysplasia	WDR19 IFT140	3.80e-05	6	56	2	24027799
Pubmed	An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.	MAB21L2 MAB21L1	3.80e-05	6	56	2	19482073
Pubmed	Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.	WDR19 IFT140	3.80e-05	6	56	2	29220510
Pubmed	Role for the IFT-A Complex in Selective Transport to the Primary Cilium.	WDR19 IFT140	3.80e-05	6	56	2	27806291
Pubmed	Role of growth hormone (GH) in liver regeneration.	GH2 IGFALS	5.32e-05	7	56	2	15242989
Pubmed	Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors.	WDR19 IFT140	5.32e-05	7	56	2	27932497
Pubmed	Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development.	MAB21L2 MAB21L1	5.32e-05	7	56	2	10556287
Pubmed	A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.	GSDMD FAS	9.10e-05	9	56	2	32268091
Pubmed	TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.	WDR19 IFT140	9.10e-05	9	56	2	20889716
Pubmed	Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA.	IFT140 IGFALS	1.14e-04	10	56	2	10899141
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	RNF213 TNKS1BP1 PAK1IP1 DHX29 NXF1	1.97e-04	332	56	5	25693804
Pubmed	T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.	GSDMD FAS	2.29e-04	14	56	2	31848486
Pubmed	Cell-autonomous involvement of Mab21l1 is essential for lens placode development.	MAB21L2 MAB21L1	2.29e-04	14	56	2	12642482
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	THADA ARHGEF40 DNAJC14 LRRC56 TNKS1BP1 WDR90 HCFC1 GGA3	3.72e-04	1105	56	8	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	IFT140 THADA ARHGEF40 HMCN2 TAF1C RNF213 CHPF2 WDTC1	3.97e-04	1116	56	8	31753913
Pubmed	Requirement for Mab21l2 during development of murine retina and ventral body wall.	MAB21L2 MAB21L1	4.28e-04	19	56	2	15385160
Pubmed	GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.	DNHD1 THADA	6.30e-04	23	56	2	23725790
Pubmed	Interaction of S100A6 Protein with the Four-Helical Cytokines.	GH2 FLT3LG	9.37e-04	28	56	2	37759746
GeneFamily	WD repeat domain containing	WDR19 IFT140 NWD1 GNB1L WDR90 WDR41 PAK1IP1 WDTC1 WDR47	3.56e-09	262	39	9	362
GeneFamily	Fibulins	FBLN5 HMCN2	1.26e-04	8	39	2	556
GeneFamily	Beta 4-glycosyltransferases	CHPF2 B4GALNT3	6.04e-04	17	39	2	425
GeneFamily	Intraflagellar transport proteins\|Tetratricopeptide repeat domain containing	WDR19 IFT140	1.21e-03	24	39	2	615
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#1	FLT3LG GSDMD DACT3 RNF213 MAB21L2 PEAK1 MAB21L1	3.63e-05	371	53	7	Facebase_RNAseq_e9.5_Maxillary Arch_1000_K1
Drug	Vinpocetine [42971-09-5]; Up 200; 11.4uM; PC3; HT_HG-U133A	CAPN9 USP5 IGFALS TAF1C GAL3ST4 WDTC1	7.11e-06	197	54	6	5859_UP
Drug	Adiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; MCF7; HT_HG-U133A	IFT140 USP5 TAF1C LRRC61 HCFC1 WDR47	7.11e-06	197	54	6	7037_DN
Disease	aplastic anemia (is_marker_for)	FLT3LG FAS	1.05e-04	9	51	2	DOID:12449 (is_marker_for)
Disease	Jeune thoracic dystrophy	WDR19 IFT140	1.59e-04	11	51	2	C0265275
Disease	ficolin-3 measurement	B4GALNT3 WDTC1	1.91e-04	12	51	2	EFO_0020392
Disease	retinitis pigmentosa (is_implicated_in)	WDR19 IFT140	2.30e-03	41	51	2	DOID:10584 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTENIGDSGLCFELW	ARHGEF40	1326	Q8TER5
LLEQGDLGSWDLLIC	CPED1	141	A4D0V7
DWIDLSCNTSGNLLL	B4GALNT3	651	Q6L9W6
APAWVLLDECGLELG	GSDMD	436	P57764
WDYSGLDGLEELELC	GPR25	16	O00155
LEDGLFEGLGSLWDL	IGFALS	161	P35858
LRGLWDCLPADLVGE	ANKRD35	701	Q8N283
TNVELGLGCEELQWL	DNHD1	3691	Q96M86
WLCLNLSDDALPEGF	DHX29	161	Q7Z478
AGLILSQLGDLSSWC	ASTN1	1226	O14525
GSEDALLCLWDLQAR	NWD1	1406	Q149M9
LVCDSSDGLLLGGWE	RGS3	426	P49796
GELILLCALLGTLWE	PCDHGA8	11	Q9Y5G5
GCRLGDLWTLDIDTL	HCFC1	226	P51610
LGLWGAEELCQLGQA	DNAJC14	236	Q6Y2X3
GLLLLWLSGARCDIQ	IGKV1D-33	11	P01593
LAELCGQTWQGDGLL	LDLRAD2	31	Q5SZI1
QGRDLKLCLWDLAEG	GNB1L	86	Q9BYB4
ECLGLEWLDLSGNAL	LRRC61	51	Q9BV99
EVLGLAGADVELQCW	HMCN2	1446	Q8NDA2
ASNLQDEELCGGLWR	FLT3LG	61	P49771
DEELCGGLWRLVLAQ	FLT3LG	66	P49771
KLEELWLDGNSLCDT	NXF1	316	Q9UBU9
LDREGGISLEDWLCA	PEAK1	1711	Q9H792
ALSWLDEELLCLGLA	GGA3	386	Q9NZ52
LVLLADALCWGLDDV	GAL3ST4	311	Q96RP7
CALPLGDAWLSLEAQ	LACTBL1	446	A8MY62
LRGWLEGSLAGLCEL	DACT3	16	Q96B18
GACDSLLWIREELGN	ERICH4	46	A6NGS2
WDESCLGDRLNGILL	MAB21L2	291	Q9Y586
LCALLSLLAGHGWAD	KLK9	6	Q9UKQ9
GLLLLWLSGARCDIQ	IGKV1-33	11	P01594
TDGYWLLEGQCLDID	FBLN5	156	Q9UBX5
QGELGDCWLLAAIAS	CAPN9	91	O14815
NCLLSGDRLGVLLLW	IFT140	116	Q96RY7
LQLTLAWILLEACGG	RTBDN	16	Q9BSG5
ILLGWLLGESDDLVA	THADA	1801	Q6YHU6
LWLARCGLADLDGIA	LRRC56	121	Q8IYG6
WDESCLGDRLNGILL	MAB21L1	291	Q13394
RWEQLLLDEACTGGA	TAF1C	201	Q15572
QDGSLIDLCGATLLW	PELI2	241	Q9HAT8
CWNAENLLALGGEDK	WDR19	146	Q8NEZ3
DEWLGRCLIDSLGVG	CHPF2	256	Q9P2E5
DLHLQEQGSGIDWCL	PLEKHS1	281	Q5SXH7
LAFGLLCLSWLQEGS	GH2	11	P01242
EKIELLLEGSLDWLC	RNF213	631	Q63HN8
GCDDLDLSLLSWLQN	WDR47	236	O94967
NCLEWNEKGDLLASG	WDTC1	51	Q8N5D0
ELSGLLNTTDLACWG	ZNF488	191	Q96MN9
CEDLGVEGTDLWLAA	WDR90	1581	Q96KV7
KEEGSRSNLGWLCLL	FAS	166	P25445
WGNNLGLRDLEVTCD	TNKS1BP1	1311	Q9C0C2
LISGAEDGLICIWDA	PAK1IP1	96	Q9NWT1
KEGLLSCGISLDWDE	STARD4	126	Q96DR4
ENLWLNLTDGSILCG	USP5	206	P45974
GGNDLCVWNRKLDLL	WDR41	151	Q9HAD4
VNGDKLWLVLELCSG	MYO3A	91	Q8NEV4