Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ankyrin binding	SPTBN4 SPTB SPTBN1	7.88e-05	23	73	3	GO:0030506
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTB SPTBN1	3.38e-06	9	73	3	GO:0008091
GeneOntologyCellularComponent	cytoplasmic stress granule	DDX19B PRKAA2 TRIM21 KPNB1	3.57e-04	96	73	4	GO:0010494
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTB SPTBN1	4.26e-04	9	73	2	GO:0014731
Domain	Spectrin_bsu	SPTBN4 SPTB SPTBN1	2.19e-07	4	72	3	IPR016343
Domain	Spectrin	SPTBN4 TRIO SPTB SPTBN1	1.70e-06	23	72	4	PF00435
Domain	Spectrin_repeat	SPTBN4 TRIO SPTB SPTBN1	4.48e-06	29	72	4	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN4 TRIO SPTB SPTBN1	6.73e-06	32	72	4	IPR018159
Domain	SPEC	SPTBN4 TRIO SPTB SPTBN1	6.73e-06	32	72	4	SM00150
Domain	Actinin_actin-bd_CS	SPTBN4 SPTB SPTBN1	9.20e-05	23	72	3	IPR001589
Domain	ACTININ_2	SPTBN4 SPTB SPTBN1	9.20e-05	23	72	3	PS00020
Domain	ACTININ_1	SPTBN4 SPTB SPTBN1	9.20e-05	23	72	3	PS00019
Domain	CH	SPTBN4 SPTB SPTBN1 ASPM	1.15e-04	65	72	4	SM00033
Domain	CH	SPTBN4 SPTB SPTBN1 ASPM	1.54e-04	70	72	4	PF00307
Domain	-	SPTBN4 SPTB SPTBN1 ASPM	1.62e-04	71	72	4	1.10.418.10
Domain	CH	SPTBN4 SPTB SPTBN1 ASPM	1.81e-04	73	72	4	PS50021
Domain	CH-domain	SPTBN4 SPTB SPTBN1 ASPM	2.01e-04	75	72	4	IPR001715
Domain	KRAB	ZNF729 ZNF182 ZNF718 ZNF43 ZNF254 ZNF99 ZNF730	4.53e-04	358	72	7	PS50805
Domain	KRAB	ZNF729 ZNF182 ZNF718 ZNF43 ZNF254 ZNF99 ZNF730	4.53e-04	358	72	7	PF01352
Domain	PH_dom-spectrin-type	SPTBN4 SPTBN1	5.18e-04	9	72	2	IPR001605
Domain	KRAB	ZNF729 ZNF182 ZNF718 ZNF43 ZNF254 ZNF99 ZNF730	5.43e-04	369	72	7	SM00349
Domain	KRAB	ZNF729 ZNF182 ZNF718 ZNF43 ZNF254 ZNF99 ZNF730	5.52e-04	370	72	7	IPR001909
Domain	zf-C2H2_6	ZNF729 ZNF182 ZNF718 ZNF43 ZNF99 ZNF730	1.33e-03	314	72	6	PF13912
Domain	SEA	MUC16 ADGRF1	3.22e-03	22	72	2	PF01390
Domain	SEA	MUC16 ADGRF1	3.52e-03	23	72	2	PS50024
Domain	SEA_dom	MUC16 ADGRF1	3.52e-03	23	72	2	IPR000082
Domain	JmjC	KDM5D HR	3.83e-03	24	72	2	PF02373
Domain	HECT	SMURF1 SMURF2	4.83e-03	27	72	2	PF00632
Domain	HECTc	SMURF1 SMURF2	4.83e-03	27	72	2	SM00119
Domain	HECT_dom	SMURF1 SMURF2	4.83e-03	27	72	2	IPR000569
Domain	HECT	SMURF1 SMURF2	4.83e-03	27	72	2	PS50237
Domain	zf-C2H2	ZNF729 ZNF182 ZNF718 ZNF43 ZNF254 ADNP ZNF99 ZNF730	5.10e-03	693	72	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF182 ZNF718 ZNF43 ZNF254 ADNP ZNF99 ZNF730	5.14e-03	694	72	8	IPR013087
Domain	Ig-like_fold	FNDC3B CD2 MYLK TRIO IGHD CRLF3 IGSF5 NCR3LG1	5.69e-03	706	72	8	IPR013783
Domain	Arm	ODAD2 KPNB1	6.34e-03	31	72	2	PF00514
Domain	JMJC	KDM5D HR	6.75e-03	32	72	2	PS51184
Domain	JmjC_dom	KDM5D HR	6.75e-03	32	72	2	IPR003347
Domain	JmjC	KDM5D HR	7.16e-03	33	72	2	SM00558
Domain	GPS	ADGRF1 ADGRD1	7.59e-03	34	72	2	SM00303
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTB SPTBN1	7.77e-06	10	58	3	MM15112
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF355P ZNF718 ZNF43 ZNF254 ZNF99	4.06e-11	29	76	6	14563677
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF355P ZNF43 ZNF254 ZNF99	1.29e-10	15	76	5	15885501
Pubmed	A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.	SPTBN4 SPTB SPTBN1	1.00e-08	3	76	3	11294830
Pubmed	β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.	SPTBN4 SPTB SPTBN1	1.00e-08	3	76	3	32425157
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF43 ZNF99	1.19e-06	10	76	3	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF43 ZNF99	1.63e-06	11	76	3	15469996
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTBN4 SPTB SPTBN1	1.63e-06	11	76	3	17607528
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF43 ZNF99	2.82e-06	13	76	3	19850934
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN4 SPTB SPTBN1	2.82e-06	13	76	3	18796539
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF355P ZNF43 ZNF99	4.14e-06	49	76	4	9630514
Pubmed	The functions and regulation of Smurfs in cancers.	SMURF1 SMURF2	4.71e-06	2	76	2	31899247
Pubmed	SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.	SMURF1 SMURF2	4.71e-06	2	76	2	33090007
Pubmed	Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.	SMURF1 SMURF2	4.71e-06	2	76	2	18927080
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN4 SPTB SPTBN1	7.99e-06	18	76	3	12119179
Pubmed	The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.	SMURF1 SMURF2	1.41e-05	3	76	2	23475958
Pubmed	USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.	SMURF1 SMURF2	1.41e-05	3	76	2	30244169
Pubmed	Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.	SMURF1 SMURF2	1.41e-05	3	76	2	15173588
Pubmed	MMP3 in Comparison to CA 125, HE4 and the ROMA Algorithm in Differentiation of Ovarian Tumors.	MUC16 MMP3	1.41e-05	3	76	2	27268637
Pubmed	The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.	SPTB SPTBN1	1.41e-05	3	76	2	8479293
Pubmed	Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.	SMURF1 SMURF2	1.41e-05	3	76	2	37537194
Pubmed	Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.	SMURF1 SMURF2	1.41e-05	3	76	2	25051198
Pubmed	Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity.	SPTBN4 SPTB	1.41e-05	3	76	2	32052742
Pubmed	Developmental expression of brain beta-spectrin isoform messenger RNAs.	SPTB SPTBN1	1.41e-05	3	76	2	1467942
Pubmed	Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.	SMURF1 SMURF2	1.41e-05	3	76	2	24925320
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SPTBN4 EPRS1 LARP6 COMMD1 TRIO SPTB SPTBN1 TUBGCP5 SMURF2 CNOT3 DOP1B KPNB1	2.15e-05	1285	76	12	35914814
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTBN4 SPTB SPTBN1	2.23e-05	25	76	3	8493579
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TRPM6 ZNF355P EPRS1 NRDE2 ZNF182 SPTBN1 ZNF254 SMURF1 CUBN NLRP4 VPS13B	2.30e-05	1084	76	11	11544199
Pubmed	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation.	SMURF1 SMURF2	2.82e-05	4	76	2	27086113
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTB SPTBN1	2.82e-05	4	76	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTB SPTBN1	2.82e-05	4	76	2	3862089
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTB SPTBN1	2.82e-05	4	76	2	21412925
Pubmed	Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.	SMURF1 SMURF2	2.82e-05	4	76	2	30566427
Pubmed	Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.	SMURF1 SMURF2	2.82e-05	4	76	2	34370213
Pubmed	The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.	SMURF1 TRIM21	2.82e-05	4	76	2	37481723
Pubmed	Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.	SMURF1 SMURF2	2.82e-05	4	76	2	16373342
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTB SPTBN1	2.82e-05	4	76	2	12820899
Pubmed	The WW1 Domain Enhances Autoinhibition in Smurf Ubiquitin Ligases.	SMURF1 SMURF2	2.82e-05	4	76	2	31628949
Pubmed	Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.	SMURF1 SMURF2	4.69e-05	5	76	2	20937913
Pubmed	An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.	SMURF1 SMURF2	4.69e-05	5	76	2	28839186
Pubmed	Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.	SMURF1 SMURF2	4.69e-05	5	76	2	14722617
Pubmed	Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.	SMURF1 SMURF2	4.69e-05	5	76	2	21402695
Pubmed	NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.	SMURF1 SMURF2	4.69e-05	5	76	2	28798345
Pubmed	Large-scale discovery of novel genetic causes of developmental disorders.	TRIO ADNP	4.69e-05	5	76	2	25533962
Pubmed	Inhibition of HECT E3 ligases as potential therapy for COVID-19.	SMURF1 SMURF2	4.69e-05	5	76	2	33762578
Pubmed	ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.	SMURF1 SMURF2	7.03e-05	6	76	2	28049720
Pubmed	Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.	SMURF1 SMURF2	7.03e-05	6	76	2	19318350
Pubmed	The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.	ZNF355P ZNF254	7.03e-05	6	76	2	30846446
Pubmed	Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.	SMURF1 SMURF2	7.03e-05	6	76	2	23781096
Pubmed	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.	SMURF1 SMURF2	7.03e-05	6	76	2	21897371
Pubmed	Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.	SMURF1 SMURF2	7.03e-05	6	76	2	22921829
Pubmed	Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.	SMURF1 SMURF2	7.03e-05	6	76	2	32361710
Pubmed	CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.	SMURF1 SMURF2	9.83e-05	7	76	2	14701756
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	SMURF1 SMURF2	9.83e-05	7	76	2	30587574
Pubmed	SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.	SMURF1 SMURF2	9.83e-05	7	76	2	27292644
Pubmed	The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.	SMURF1 SMURF2	9.83e-05	7	76	2	28169289
Pubmed	Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively.	SPTB LAMA1	9.83e-05	7	76	2	8276400
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	SMURF1 SMURF2	1.31e-04	8	76	2	19307600
Pubmed	Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.	SMURF1 SMURF2	1.31e-04	8	76	2	28881580
Pubmed	Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.	SMURF1 SMURF2	1.31e-04	8	76	2	20484049
Pubmed	Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.	SMURF1 SMURF2	1.68e-04	9	76	2	29659741
Pubmed	Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons.	SPTBN1 UGT8	1.68e-04	9	76	2	16551741
Pubmed	Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).	SMURF1 SMURF2	2.10e-04	10	76	2	15221015
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTB SPTBN1	2.10e-04	10	76	2	22159418
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	SMURF1 SMURF2	2.10e-04	10	76	2	25092867
Pubmed	A B-Myb complex containing clathrin and filamin is required for mitotic spindle function.	SPTBN1 MYBL2	2.10e-04	10	76	2	18548008
Pubmed	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.	SMURF1 SMURF2	2.10e-04	10	76	2	15138260
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	SMURF1 SMURF2	2.56e-04	11	76	2	17996703
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	SMURF1 SMURF2	2.56e-04	11	76	2	22773947
Pubmed	Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.	EPRS1 SPTBN1	2.56e-04	11	76	2	24337748
Pubmed	AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.	PRKAA2 KPNB1	2.56e-04	11	76	2	27430620
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MYO10 SMURF1 VPS13B SENP7 DOP1B WDR48	2.71e-04	407	76	6	12693553
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	SMURF1 SMURF2	3.07e-04	12	76	2	24107629
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF355P MAS1 ZNF254	3.29e-04	61	76	3	8662221
Pubmed	The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection.	TRIM21 SMURF2	3.62e-04	13	76	2	36379255
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ZNF182 FRRS1 MYO10 CRLF3 SPTBN1 ASPM MRNIP TRIM21 ADGRD1 DOP1B	3.65e-04	1242	76	10	30973865
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF729 ZNF718 ZNF43 ZNF254 KDM5D ZNF99 DOP1B MYBL2	3.84e-04	808	76	8	20412781
Pubmed	TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.	SMURF1 SMURF2	4.22e-04	14	76	2	21791611
Pubmed	Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development.	LAMA1 MMP3	4.22e-04	14	76	2	32109382
Pubmed	Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.	ZNF182 ZNF43	4.22e-04	14	76	2	2014798
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	SMURF1 SMURF2	4.22e-04	14	76	2	26147758
Pubmed	Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer.	SMURF1 SMURF2	4.22e-04	14	76	2	29263404
Pubmed	The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex.	COMMD1 TRAPPC8 TUBGCP5	5.37e-04	72	76	3	33726789
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FNDC3B EPRS1 NRDE2 SLC30A5 CMTR2 HR WDR48	5.53e-04	650	76	7	38777146
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF43 ZNF99	5.54e-04	16	76	2	8467795
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	SMURF1 SMURF2	5.54e-04	16	76	2	25723849
Pubmed	Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.	CRLF3 SPTBN1	5.54e-04	16	76	2	23870131
Pubmed	Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.	SPTBN4 SPTBN1	5.54e-04	16	76	2	21745462
Pubmed	Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.	ASPM MYBL2	5.54e-04	16	76	2	32469866
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	SMURF1 SMURF2	6.27e-04	17	76	2	28292929
Pubmed	Changes in thyroid status during perinatal development of MCT8-deficient male mice.	HR SLC16A10	7.05e-04	18	76	2	23696569
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	FNDC3B TRIO XIRP2 SPTB SPTBN1 KPNB1	7.76e-04	497	76	6	23414517
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	SMURF1 SMURF2	7.87e-04	19	76	2	21572392
Pubmed	Lhx2-/- mice develop liver fibrosis.	LAMA1 MMP3	7.87e-04	19	76	2	15536133
Pubmed	Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.	SPTB SPTBN1	8.73e-04	20	76	2	18723693
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF355P ZNF254	8.73e-04	20	76	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF355P ZNF254	8.73e-04	20	76	2	2542606
Pubmed	A quantitative survey of gravity receptor function in mutant mouse strains.	SPTBN4 HR	8.73e-04	20	76	2	16235133
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	SMURF1 SMURF2	9.63e-04	21	76	2	37005481
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	TRPM6 MYLK AK5 SMURF1 MMP3 GALNT5 SMURF2	1.09e-03	730	76	7	34857952
Pubmed	Bone morphogenetic proteins.	SMURF1 SMURF2	1.16e-03	23	76	2	15621726
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF43 ZNF254 ZNF99 ZNF730	1.94e-06	122	76	5	chr19p12
Cytoband	19p12	ZNF729 ZNF254 ZNF99 ZNF730	1.59e-05	90	76	4	19p12
Cytoband	1p31	AK5 PRKAA2	5.56e-04	21	76	2	1p31
Cytoband	21q22.2	IGSF5 DOP1B	1.38e-03	33	76	2	21q22.2
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTB SPTBN1	9.24e-07	7	55	3	1113
Coexpression	TERAO_AOX4_TARGETS_SKIN_DN	ZNF729 ZNF43 MRNIP ZNF99	1.27e-06	28	76	4	MM925
Coexpression	GSE25088_CTRL_VS_IL4_STIM_STAT6_KO_MACROPHAGE_UP	EPRS1 PRKAA2 CCDC168 CUBN ZNF99 KPNB1	2.36e-05	197	76	6	M7930
Coexpression	GSE11057_NAIVE_VS_EFF_MEMORY_CD4_TCELL_UP	TBC1D32 ZNF43 AK5 CRLF3 SPTBN1 SLC16A10	2.43e-05	198	76	6	M3104
ToppCell	severe_influenza-B_cell\|severe_influenza / disease group, cell group and cell class (v2)	CCDC71 IGHD UGT8 MRNIP MYBL2	2.71e-06	128	76	5	92b250186d6bb08ce4f2f5cc4fb93928f6b92d3a
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPM6 AK5 HASPIN ASPM DOP1B	1.08e-05	170	76	5	cf22a843ae2d9cd6693507fed2b7c6a45abea10e
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TDRD15 HASPIN ASPM MUC16 MYBL2	1.28e-05	176	76	5	dc4e939a07bad21ab36181f9588df3fa662f9a92
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CRACR2A IGSF5 MUC16 MMP3 ADGRF1	1.31e-05	177	76	5	a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CRACR2A IGSF5 MUC16 MMP3 ADGRF1	1.31e-05	177	76	5	363e07b0f347f3716d530a28ead854b98e27d37c
ToppCell	severe_influenza-B_cell\|World / disease group, cell group and cell class (v2)	CCDC71 IGHD UGT8 MYBL2	1.44e-05	86	76	4	7b595bcba4bcb72b7de7c06e19f690f0c739c529
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LARP6 DYTN MMP3 ADGRD1 SLC16A10	1.58e-05	184	76	5	d754c3de621429b220ae4ac426cdfc619e848462
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	1.94e-05	192	76	5	8dc3016601148243196e925641c9507e9d58c9e0
ToppCell	Control-Lymphoid-Proliferating_CD4_T_cells\|Control / Condition, Lineage and Cell class	SPTBN1 HASPIN ASPM ZNF730 MYBL2	1.99e-05	193	76	5	33d409d6ed1c606337248587ad997ac5f67f081d
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRPM6 LARP6 MYLK CLCN4 UGT8	1.99e-05	193	76	5	947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.20e-05	197	76	5	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.25e-05	198	76	5	bdabdb11217ea16e5863aa6bfb0f04d48b17f81e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.30e-05	199	76	5	214a6a267e77e5508867b9eb48c4fbc7855ed0a0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.36e-05	200	76	5	acdef0b9096c774040948fc75621ff2b08ea2ee8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.36e-05	200	76	5	091a18d6efed81cab99955c3047f172170f70476
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRACR2A PRKAA2 MUC16 GALNT5 DOP1B	2.36e-05	200	76	5	ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.36e-05	200	76	5	3b8513defe25262ab4b492345b2628570eaefd17
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.36e-05	200	76	5	0bfd41c12887479ceb62c3db0a3c3ba5007eb62b
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.36e-05	200	76	5	159377d904394d91e09913131e9a93e08189955a
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP6 MYLK CLCN4 AK5 UGT8	2.36e-05	200	76	5	d30316836494f33ca46d4e415fd2ed179e9cb5ee
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRACR2A PRKAA2 UGT8 MUC16 DOP1B	2.36e-05	200	76	5	85c0f038bcfb42669dca2b80273b0f8a1421405e
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN4 SPTB SPTBN1	6.05e-08	4	74	3	DOID:0050882 (implicated_via_orthology)
Disease	Sjogren's syndrome (is_marker_for)	MUC16 MMP3	1.65e-03	24	74	2	DOID:12894 (is_marker_for)
Disease	coronary artery disease (is_implicated_in)	MYLK MMP3 CUBN	2.06e-03	100	74	3	DOID:3393 (is_implicated_in)
Disease	primary biliary cholangitis (biomarker_via_orthology)	MAS1 MMP3	2.25e-03	28	74	2	DOID:12236 (biomarker_via_orthology)
Disease	visceral heterotaxy (implicated_via_orthology)	TBC1D32 ODAD2	3.90e-03	37	74	2	DOID:0050545 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WKSDIASHFSNKRKK	ADNP	796	Q9H2P0
HESIAKAWKKTSLLS	TBC1D32	636	Q96NH3
SEVRAAFKHKTKVWS	ADGRD1	811	Q6QNK2
WKQIKKSQTSHTRRI	ADGRF1	611	Q5T601
AVKKAKWHLGIRSQS	PRKAA2	396	P54646
KLSQRVITHKWTTSL	CD2	166	P06729
VITHKWTTSLSAKFK	CD2	171	P06729
HKKSLQKLVSDWNTL	SH3BP1	141	Q9Y3L3
KHLSRNNWLVKKSSI	CMTR2	411	Q8IYT2
KAAKANTAASRASWK	CRACR2A	391	Q9BSW2
HRKITSKSKESIWEF	CLCN4	46	P51793
WDTIKKKKISASTSH	ASPM	151	Q8IZT6
LAAKALKKQSWRFHT	CNOT3	686	O75175
RLFQAHQVKKSVKWT	MRNIP	16	Q6NTE8
SLTDKSKHKTETWVS	MUC16	3381	Q8WXI7
AWVTVHEKKSSRKSE	MYLK	596	Q15746
VVKIRKNTWASHSSK	MAS1	211	P04201
LLRKKIHSTSSNRKW	AK5	166	Q9Y6K8
ILKHWNSFDTQTLKK	NCR3LG1	301	Q68D85
VAAVWSRKKAQRHSK	DOP1B	1691	Q9Y3R5
QVLTAHSWREKASKT	KDM5D	1061	Q9BY66
HSWREKASKTFLKKN	KDM5D	1066	Q9BY66
NAKKVTHTLKSNSWL	MMP3	461	P08254
HTKLKKTWLTRHSEQ	HR	376	O43593
EKLWSFTKKASHIQL	CRLF3	126	Q8IUI8
WEGTSTEKKHSRKQV	NRDE2	206	Q9H7Z3
SLKLKKRWFVLTHNS	MYO10	1411	Q9HD67
LLTSFKKVKHLTRDW	LARP6	131	Q9BRS8
LQRALSAVSTWHKKA	GOLGA6L2	181	Q8N9W4
KFVIHSDLSKAASWK	TUBGCP5	71	Q96RT8
AHAKQKFSRLWSSKS	NLRP4	101	Q96MN2
WQKSVHKLRKVSATS	FAM182B	61	Q5T319
TIISHSNKLWLKFKS	CUBN	1131	O60494
KAVHSWSRISTAGKK	CCDC71	11	Q8IV32
VATWKSLKARKSATV	IGSF5	216	Q9NSI5
TRIHKLKTNQDSLWT	DYTN	356	A2CJ06
SHRSASKKTEIKVYW	FRRS1	116	Q6ZNA5
RNKGLKWLHKSTSVF	GALNT5	876	Q7Z7M9
KLAHRSKSSLTLQWK	FNDC3B	386	Q53EP0
RKIKSLWSRNKHSTV	UGT8	501	Q16880
HTRKTASWLAAELSK	DDX19B	341	Q9UMR2
VQHTASKSKKEIFRW	IGHD	86	P01880
RRSKTNKAKTLATWA	KPNB1	851	Q14974
WTKTRASFSFHKKKI	HASPIN	381	Q8TF76
AAVISKFWKSHKTKI	COMMD1	91	Q8N668
HKRRTSKWKKSVFSH	CCDC168	3571	Q8NDH2
WEVKLKTHRQFSKTN	SENP7	961	Q9BQF6
YKKTTKVTWLAETTH	EPRS1	601	P07814
CLAKSKNTLKWHRSK	TDRD15	1581	B5MCY1
AVKNHWNSTIKRKVD	MYBL2	171	P10244
WSCSKSHTNKEAIRK	ODAD2	616	Q5T2S8
KWHTLQANKSKHRIT	LAMA1	2976	P25391
VQIKHKWSSSLRSIA	SLC9B2	166	Q86UD5
SEKGKQHKRRSWSIS	SHLD3	121	Q6ZNX1
GKTDSITISVWNHKK	SMURF1	71	Q9HCE7
QKKTFTKWVNSHLAR	SPTBN1	56	Q01082
TIWKKAVERLHKSFT	C11orf16	216	Q9NQ32
KSDSVTISVWNHKKI	SMURF2	71	Q9HAU4
TLKSLKESSHRWKES	XIRP2	1696	A4UGR9
FKWSSKLTVHKVIHT	ZNF99	406	A8MXY4
KAFKWSSHLTRHKVI	ZNF99	656	A8MXY4
AFKWSSKLTVHKVIH	ZNF99	741	A8MXY4
KAFNWSSILTKHKRI	ZNF718	206	Q3SXZ3
KTFSKKSHLIVHWRT	ZNF182	241	P17025
TTKSTVNKWTLKGIH	WDR48	316	Q8TAF3
KESEQWSVEKHTTKS	TRPM6	76	Q9BX84
EESRKHINTWVSKKT	SERPINB9	126	P50453
AVQKKTFTKWVNSHL	SPTBN4	61	Q9H254
QKKTFTKWVNSHLAR	SPTB	56	P11277
DWKKTVETQKSRIHA	TRIM21	166	P19474
FKWSSTLTKHKRIHN	ZNF730	321	Q6ZMV8
GKVFNWSSRLTTHKK	ZNF43	236	P17038
GKAFKWSSTLTKHKI	ZNF43	656	P17038
TKDLHSTKWLNESRK	VPS13B	901	Q7Z7G8
FSSGKTITKHQWIKI	SLC30A5	81	Q8TAD4
SSSSKHWKLQKSVNL	TRAPPC8	1126	Q9Y2L5
KAFKWSSNLTIHKRI	ZNF355P	191	Q9NSJ1
KAFIWSSTLTEHKKI	ZNF254	301	O75437
KAFIWSSTLTKHKRI	ZNF254	441	O75437
LKKSTSWHTALRLRK	TRIO	2626	O75962
KAFKWSSKLTVHKVI	ZNF729	551	A6NN14
FKWSSKLTVHKVIHT	ZNF729	721	A6NN14
WIHSKKQREISKTTG	SLC16A10	471	Q8TF71