Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	4.51e-11	431	100	17	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 HRH2 OR13C7 PTGDR2	1.26e-08	884	100	20	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8H3 HTR7 OR4C11 OR13C5 NTRK3 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 HRH2 OR13C7 PTGDR2 FCMR	7.11e-07	1353	100	22	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR8H3 OR8H1 OR2C1 OR12D2 OR12D1	4.47e-04	127	100	5	GO:0005549
GeneOntologyMolecularFunction	centromeric DNA binding	MLH3 ZW10	5.13e-04	7	100	2	GO:0019237
GeneOntologyMolecularFunction	D-glucose:sodium symporter activity	SLC5A2 SLC5A3	5.13e-04	7	100	2	GO:0005412
GeneOntologyBiologicalProcess	sensory perception of smell	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 IGF1 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	9.14e-12	465	100	18	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	2.84e-11	432	100	17	GO:0050911
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 IGF1 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	4.28e-11	582	100	19	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 IGF1 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	1.31e-10	547	100	18	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	1.72e-10	485	100	17	GO:0050907
GeneOntologyBiologicalProcess	sensory perception	OR8H3 HTR7 OR4C11 MYO6 EPYC SOBP OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 IGF1 OR13C9 ALMS1 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 CRYBG3 OR13C7	2.11e-10	1072	100	24	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	5.61e-10	524	100	17	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 IGF1 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 OR13C7	1.60e-09	722	100	19	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR13C6P OR2C1 OR10D3 OR13C9 OR12D2 OR12D1 OR10G3 OR10G2 OR13C2 HRH2 OR13C7 PTGDR2	1.02e-05	1395	100	20	GO:0007186
Domain	Olfact_rcpt	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2	8.39e-08	393	94	13	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2 HRH2 PTGDR2	2.14e-07	670	94	16	IPR017452
Domain	7tm_1	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2 HRH2 PTGDR2	2.46e-07	677	94	16	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2 HRH2 PTGDR2	2.88e-07	685	94	16	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2 HRH2 PTGDR2	3.23e-07	691	94	16	PS50262
Domain	GPCR_Rhodpsn	OR8H3 HTR7 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2 HRH2 PTGDR2	3.30e-07	692	94	16	IPR000276
Domain	Haptoglobin	HP HPR	2.51e-05	2	94	2	IPR008292
Domain	ARM-type_fold	MON2 NBEAL1 USP9X PSMD1 USP9Y LYST PPP4R4 AP2A1 XPO6	5.28e-05	339	94	9	IPR016024
Domain	ZF_CR	DNAJA4 DNAJA1	1.49e-04	4	94	2	PS51188
Domain	DnaJ	DNAJA4 DNAJA1	1.49e-04	4	94	2	IPR012724
Domain	DnaJ_CXXCXGXG	DNAJA4 DNAJA1	1.49e-04	4	94	2	PF00684
Domain	-	DNAJA4 DNAJA1	1.49e-04	4	94	2	2.10.230.10
Domain	HSP_DnaJ_Cys-rich_dom	DNAJA4 DNAJA1	2.48e-04	5	94	2	IPR001305
Domain	PH_BEACH	NBEAL1 LYST	3.71e-04	6	94	2	PF14844
Domain	ARM-like	MON2 USP9X PSMD1 USP9Y PPP4R4 AP2A1 XPO6	4.28e-04	270	94	7	IPR011989
Domain	PH-BEACH_dom	NBEAL1 LYST	6.88e-04	8	94	2	IPR023362
Domain	-	NBEAL1 LYST	6.88e-04	8	94	2	2.30.29.40
Domain	Na/solute_symporter_CS	SLC5A2 SLC5A3	6.88e-04	8	94	2	IPR018212
Domain	PH_BEACH	NBEAL1 LYST	6.88e-04	8	94	2	PS51783
Domain	BEACH_dom	NBEAL1 LYST	8.82e-04	9	94	2	IPR000409
Domain	DnaJ_C	DNAJA4 DNAJA1	8.82e-04	9	94	2	IPR002939
Domain	DnaJ_C	DNAJA4 DNAJA1	8.82e-04	9	94	2	PF01556
Domain	BEACH	NBEAL1 LYST	8.82e-04	9	94	2	PS50197
Domain	Beach	NBEAL1 LYST	8.82e-04	9	94	2	PF02138
Domain	-	NBEAL1 LYST	8.82e-04	9	94	2	1.10.1540.10
Domain	HSP40/DnaJ_pept-bd	DNAJA4 DNAJA1	8.82e-04	9	94	2	IPR008971
Domain	Beach	NBEAL1 LYST	8.82e-04	9	94	2	SM01026
Domain	-	MON2 USP9X PSMD1 PPP4R4 AP2A1 XPO6	8.99e-04	222	94	6	1.25.10.10
Domain	NA_SOLUT_SYMP_1	SLC5A2 SLC5A3	1.34e-03	11	94	2	PS00456
Domain	NA_SOLUT_SYMP_2	SLC5A2 SLC5A3	1.60e-03	12	94	2	PS00457
Domain	SSF	SLC5A2 SLC5A3	1.60e-03	12	94	2	PF00474
Domain	Na/solute_symporter	SLC5A2 SLC5A3	1.60e-03	12	94	2	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A2 SLC5A3	1.60e-03	12	94	2	PS50283
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR10D3 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2	1.98e-08	417	72	14	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2	7.14e-08	389	72	13	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	GPC1 OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR10D3 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2	5.85e-07	636	72	15	M41834
Pubmed	Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.	OR13C5 OR13C4 OR13C6P OR13C9 OR13C2 OR13C7	4.99e-13	12	102	6	12906860
Pubmed	The human olfactory receptor gene family.	OR8H3 OR4C11 OR13C5 OR13C4 OR2G3 OR8H1 OR2T11 OR2C1 OR10D3 OR13C9 OR12D2 OR10G3 OR10G2 OR13C2	6.99e-10	541	102	14	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8H3 OR4C11 OR8H1 OR2C1 OR10D3 OR12D2 OR12D1 OR10G3 OR10G2 OR13C7	6.72e-08	340	102	10	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8H3 OR4C11 OR8H1 OR2C1 OR10D3 OR12D2 OR12D1 OR10G3 OR10G2 OR13C7	6.72e-08	340	102	10	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8H3 OR4C11 OR8H1 OR2C1 OR10D3 OR12D2 OR12D1 OR10G3 OR10G2 OR13C7	7.29e-08	343	102	10	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8H3 OR4C11 OR8H1 OR2C1 OR10D3 OR12D2 OR12D1 OR10G3 OR10G2 OR13C7	7.90e-08	346	102	10	14611657
Pubmed	Local and cis effects of the H element on expression of odorant receptor genes in mouse.	OR2C1 OR10G3 OR10G2	2.44e-07	5	102	3	17662950
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MON2 MYCBP2 PMPCB DSP USP9X BMS1 PSMD1 DUSP22 PPP4R4 ARHGAP1 FBXO3 PHLPP1 CRYBG3 DNAJA1 TNS3	4.25e-07	1049	102	15	27880917
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR4C11 OR12D2 OR12D1 OR10G3 OR13C7	2.70e-06	74	102	5	15081110
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	MYCBP2 DSP PSMD1 MCM7 KEAP1 RREB1 ALMS1 CRYBG3 ZMYM3	4.10e-06	418	102	9	34709266
Pubmed	Personal receptor repertoires: olfaction as a model.	OR2T11 OR12D2 OR12D1 OR13C7	4.77e-06	38	102	4	22908908
Pubmed	Haptoglobin is degraded by iron in C57BL/6 mice: a possible link with endoplasmic reticulum stress.	HP HPR	8.52e-06	2	102	2	17644369
Pubmed	Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus.	HP HPR	8.52e-06	2	102	2	19176700
Pubmed	Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage.	HP HPR	8.52e-06	2	102	2	17962599
Pubmed	Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis.	CYP24A1 SPO11	8.52e-06	2	102	2	10622720
Pubmed	Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus.	HP HPR	8.52e-06	2	102	2	15852445
Pubmed	Plasma protein haptoglobin modulates renal iron loading.	HP HPR	8.52e-06	2	102	2	15793279
Pubmed	Haptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic mice.	HP HPR	8.52e-06	2	102	2	19490627
Pubmed	Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation.	HP HPR	8.52e-06	2	102	2	32101700
Pubmed	Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring.	HP HPR	8.52e-06	2	102	2	12039846
Pubmed	Haptoglobin polymorphisms in Latin American populations.	HP HPR	8.52e-06	2	102	2	32792581
Pubmed	Novel role of zonulin in the pathophysiology of gastro-duodenal transit: a clinical and translational study.	HP HPR	8.52e-06	2	102	2	34789790
Pubmed	Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus.	HP HPR	8.52e-06	2	102	2	16742000
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	8.52e-06	2	102	2	12895410
Pubmed	Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes.	HP HPR	8.52e-06	2	102	2	30790555
Pubmed	Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo.	HP HPR	8.52e-06	2	102	2	17082477
Pubmed	Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.	HP HPR	8.52e-06	2	102	2	2987228
Pubmed	Species-specific changes in regulatory elements of mouse haptoglobin genes.	HP HPR	8.52e-06	2	102	2	8294478
Pubmed	Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype.	HP HPR	8.52e-06	2	102	2	18599520
Pubmed	Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells.	HP HPR	8.52e-06	2	102	2	8945641
Pubmed	Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.	HP HPR	8.52e-06	2	102	2	31573976
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	8.52e-06	2	102	2	8922996
Pubmed	Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus.	HP HPR	8.52e-06	2	102	2	22749805
Pubmed	A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations.	HP HPR	8.52e-06	2	102	2	29077717
Pubmed	Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.	HP HPR	8.52e-06	2	102	2	21708824
Pubmed	Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4-IFN-β Axis.	HP HPR	8.52e-06	2	102	2	31076532
Pubmed	Aneurysm formation in proinflammatory, transgenic haptoglobin 2-2 mice.	HP HPR	8.52e-06	2	102	2	23096414
Pubmed	Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo.	HP HPR	8.52e-06	2	102	2	15667571
Pubmed	Haptoglobin deficiency facilitates the development of autoimmune inflammation.	HP HPR	8.52e-06	2	102	2	19795414
Pubmed	Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release.	HP HPR	8.52e-06	2	102	2	12562322
Pubmed	Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system.	HP HPR	8.52e-06	2	102	2	23564505
Pubmed	Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model.	HP HPR	8.52e-06	2	102	2	28423466
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	8.52e-06	2	102	2	12925892
Pubmed	Pharmacogenomic interaction between the Haptoglobin genotype and vitamin E on atherosclerotic plaque progression and stability.	HP HPR	8.52e-06	2	102	2	25618031
Pubmed	Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration.	PSEN1 APBB2	8.52e-06	2	102	2	36498839
Pubmed	Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma.	HP HPR	8.52e-06	2	102	2	14697247
Pubmed	Characterization of the mouse haptoglobin gene.	HP HPR	8.52e-06	2	102	2	8288241
Pubmed	Tissue, temporal and inducible expression pattern of haptoglobin in mice.	HP HPR	8.52e-06	2	102	2	9300815
Pubmed	Haptoglobin is required to prevent oxidative stress and muscle atrophy.	HP HPR	8.52e-06	2	102	2	24959824
Pubmed	Obesity-associated hepatosteatosis and impairment of glucose homeostasis are attenuated by haptoglobin deficiency.	HP HPR	8.52e-06	2	102	2	21873550
Pubmed	Haptoglobin levels in serum of various strains of mice.	HP HPR	8.52e-06	2	102	2	6059653
Pubmed	Structure and expression of the human haptoglobin locus.	HP HPR	8.52e-06	2	102	2	4018023
Pubmed	The acute phase protein haptoglobin regulates host immunity.	HP HPR	8.52e-06	2	102	2	18436583
Pubmed	The haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque.	HP HPR	8.52e-06	2	102	2	19775690
Pubmed	Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei.	HP HPR	8.52e-06	2	102	2	39114668
Pubmed	Haptoglobin and the Th1/Th2 balance: hints from in vitro and in vivo studies.	HP HPR	8.52e-06	2	102	2	11865978
Pubmed	Haptoglobin, an inflammation-inducible plasma protein.	HP HPR	8.52e-06	2	102	2	11865981
Pubmed	Consequences of haemolysis without haptoglobin.	HP HPR	8.52e-06	2	102	2	11865980
Pubmed	Cell type-specific and inflammatory-induced expression of haptoglobin gene in lung.	HP HPR	8.52e-06	2	102	2	7564277
Pubmed	Mechanisms regulating repression of haptoglobin production by peroxisome proliferator-activated receptor-gamma ligands in adipocytes.	HP HPR	8.52e-06	2	102	2	19952271
Pubmed	Junctions between genes in the haptoglobin gene cluster of primates.	HP HPR	8.52e-06	2	102	2	1478675
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GPC1 MAGEA4 AIMP2 MYCBP2 MYO6 PMPCB DSP BMS1 PSMD1 MCM7 AP2A1 BOP1 DNAJA1 ZMYM3 TNS3	9.54e-06	1353	102	15	29467282
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	GPC1 TANC2 CACNA2D1 ACTR3C DSP USP9X RPS6KC1 NWD2 BOP1	1.14e-05	475	102	9	31040226
Pubmed	Olfactory receptors and signalling elements in the Grueneberg ganglion.	OR8H3 OR8H1 OR2C1	1.62e-05	17	102	3	16805845
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	MON2 USP9X AP2A1 XPO6 ZW10 DNAJA1	1.73e-05	183	102	6	23956138
Pubmed	The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation.	HP HPR	2.55e-05	3	102	2	28464519
Pubmed	Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy.	HP HPR	2.55e-05	3	102	2	28440464
Pubmed	Haptoglobin modifies the hemochromatosis phenotype in mice.	HP HPR	2.55e-05	3	102	2	15613548
Pubmed	Ultraviolet-induced cyclobutane pyrimidine dimers are selectively removed from transcriptionally active genes in the epidermis of the hairless mouse.	HP HPR	2.55e-05	3	102	2	8453636
Pubmed	Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility.	FER1L4 FER1L5	2.55e-05	3	102	2	36696506
Pubmed	The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity.	PSEN1 DNAJA1	2.55e-05	3	102	2	35373908
Pubmed	Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque.	HP HPR	2.55e-05	3	102	2	17068284
Pubmed	Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency.	PSEN1 IGF1	2.55e-05	3	102	2	22230888
Pubmed	Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol.	HP HPR	2.55e-05	3	102	2	22433445
Pubmed	Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5).	HP HPR	2.55e-05	3	102	2	8786117
Pubmed	Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.	HP HPR	2.55e-05	3	102	2	12393471
Pubmed	Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.	HP HPR	2.55e-05	3	102	2	25582460
Pubmed	Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.	HP HPR	2.55e-05	3	102	2	27294203
Pubmed	Haptoglobin enhances cardiac transplant rejection.	HP HPR	2.55e-05	3	102	2	25801896
Pubmed	Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.	HP HPR	2.55e-05	3	102	2	17919498
Pubmed	Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin.	HP HPR	2.55e-05	3	102	2	30771488
Pubmed	A unique form of haptoglobin produced by murine hematopoietic cells supports B-cell survival, differentiation and immune response.	HP HPR	2.55e-05	3	102	2	23548836
Pubmed	A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.	HP HPR	2.55e-05	3	102	2	22403646
Pubmed	Increased susceptibility in Hp knockout mice during acute hemolysis.	HP HPR	2.55e-05	3	102	2	9731043
Pubmed	Haptoglobin, inflammation, and tumorigenesis in the MIN mouse.	HP HPR	2.55e-05	3	102	2	11865977
Pubmed	Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice.	HP HPR	2.55e-05	3	102	2	30194503
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	MON2 CACNA2D1 MYO6 PMPCB USP9X PSMD1 MCM7	3.98e-05	313	102	7	38270169
Pubmed	Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis.	MYO6 AP2A1	5.09e-05	4	102	2	11447109
Pubmed	IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.	HP HPR	5.09e-05	4	102	2	28286877
Pubmed	Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes.	HP HPR	5.09e-05	4	102	2	7774933
Pubmed	Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, intramural hemorrhage and impaired wound healing after myocardial infarction.	HP HPR	5.09e-05	4	102	2	23274064
Pubmed	Restricted growth and insulin-like growth factor-1 deficiency in mice lacking presenilin-1 in the neural crest cell lineage.	PSEN1 IGF1	5.09e-05	4	102	2	19665542
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GPC1 MAGEA4 AIMP2 MYO6 PMPCB DSP BMS1 MCM7 KEAP1 ARHGAP1 AP2A1 BOP1 DNAJA1	8.00e-05	1257	102	13	36526897
Pubmed	Protein interaction and microRNA network analysis in osteoarthritis meniscal cells.	DSP IGF1	8.47e-05	5	102	2	23546957
Pubmed	Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.	SPO11 MLH3	8.47e-05	5	102	2	24390283
Pubmed	Linkage of the gene for uncoupling protein to esterase-1,2 and haptoglobin in the rat.	HP HPR	8.47e-05	5	102	2	8228167
Pubmed	Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein.	HP HPR	8.47e-05	5	102	2	19433579
Pubmed	Hsp40 chaperones promote degradation of the HERG potassium channel.	DNAJA4 DNAJA1	8.47e-05	5	102	2	19940115
Pubmed	The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.	ACTN3 ALMS1	1.27e-04	6	102	2	22693585
Pubmed	Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography.	OR2C1 OR13C7	1.27e-04	6	102	2	26450880
Cytoband	9q31.1	OR13C5 OR13C4 OR13C9 OR13C2	2.18e-06	41	102	4	9q31.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q31	OR13C5 OR13C4 NR4A3 OR13C9 OR13C2	1.45e-05	137	102	5	chr9q31
Cytoband	6p22.2-p21.31	OR12D2 OR12D1	4.87e-05	5	102	2	6p22.2-p21.31
Cytoband	14q24.3	PSEN1 ISM2 MLH3 VRTN	5.76e-05	93	102	4	14q24.3
Cytoband	9p13.3	OR13C6P OR13C7 DNAJA1	6.40e-04	75	102	3	9p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	PSEN1 ISM2 MLH3 VRTN	1.06e-03	200	102	4	chr14q24
GeneFamily	Olfactory receptors, family 13	OR13C5 OR13C4 OR13C6P OR13C9 OR13C2 OR13C7	3.08e-10	23	72	6	162
GeneFamily	Olfactory receptors, family 12	OR12D2 OR12D1	4.68e-05	3	72	2	160
GeneFamily	Ferlin family	FER1L4 FER1L5	2.32e-04	6	72	2	828
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 LYST	5.53e-04	9	72	2	1230
GeneFamily	Olfactory receptors, family 10	OR10D3 OR10G3 OR10G2	2.32e-03	66	72	3	157
GeneFamily	Lipases\|Arylacetamide deacetylase family	LIPM LIPH	3.43e-03	22	72	2	464
ToppCell	(2)_5-FU-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)\|(2)_5-FU / Stress and Cell class	GPC1 MYCBP2 SLC5A3 IGF1 HP TNS3	4.34e-06	187	101	6	6bbf0f7fe203274dae8d582652f35cd3187c0065
ToppCell	(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells\|(0)_Normal/No_Treatment / Stress and Cell class	GPC1 APBB2 SLC5A3 IGF1 HP TNS3	5.06e-06	192	101	6	7a2ad0bdae647b88e799e62767605f2f3c5a426f
Drug	CP-320650-01 [172079-28-6]; Up 200; 10uM; PC3; HT_HG-U133A	NTRK3 CYP24A1 APBB2 USP9Y MAPK8IP3 SLC5A2 SLC5A3 DNAJA4	2.03e-06	199	96	8	3822_UP
Disease	Pick's disease (is_implicated_in)	PSEN1 MAP2K6	3.14e-05	3	96	2	DOID:11870 (is_implicated_in)
Disease	level of izumo sperm-egg fusion protein 4 in blood serum	HP HPR	6.26e-05	4	96	2	OBA_2044625
Disease	lung cancer (biomarker_via_orthology)	HP HPR	6.26e-05	4	96	2	DOID:1324 (biomarker_via_orthology)
Disease	level of haptoglobin in blood serum	HP HPR	6.26e-05	4	96	2	OBA_2041919
Disease	hepatocellular adenoma (biomarker_via_orthology)	HP HPR	1.04e-04	5	96	2	DOID:0050868 (biomarker_via_orthology)
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	FER1L4 FER1L5	2.18e-04	7	96	2	DOID:11724 (implicated_via_orthology)
Disease	heparin cofactor 2 measurement	HP HPR	2.18e-04	7	96	2	EFO_0008150
Disease	glucose measurement	MYCBP2 RREB1 SLC5A3 ARHGAP1 GALNT9 BOP1 CDHR4	2.48e-04	380	96	7	EFO_0004468
Disease	anemia (phenotype), response to ribavirin	CYP24A1 DNAH17	3.72e-04	9	96	2	EFO_0004272, GO_1901559
Disease	cholestasis (biomarker_via_orthology)	IGF1 HP HPR	5.52e-04	49	96	3	DOID:13580 (biomarker_via_orthology)
Disease	pulmonary embolism (biomarker_via_orthology)	HP HPR	6.77e-04	12	96	2	DOID:9477 (biomarker_via_orthology)
Disease	Alzheimer's disease (implicated_via_orthology)	PSEN1 DNAJA4 DNAJA1	8.60e-04	57	96	3	DOID:10652 (implicated_via_orthology)
Disease	diastolic blood pressure, body mass index	KEAP1 EFHC2	1.22e-03	16	96	2	EFO_0004340, EFO_0006336
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	IGF1 HP HPR	1.26e-03	65	96	3	DOID:0080208 (biomarker_via_orthology)
Disease	hypertrophic cardiomyopathy (is_marker_for)	DSP IGF1	1.38e-03	17	96	2	DOID:11984 (is_marker_for)
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	HP HPR	1.73e-03	19	96	2	DOID:9744 (biomarker_via_orthology)
Disease	atherosclerosis (biomarker_via_orthology)	HP HPR	1.92e-03	20	96	2	DOID:1936 (biomarker_via_orthology)
Disease	haptoglobin measurement	HP HPR	2.11e-03	21	96	2	EFO_0004640
Disease	pulmonary embolism	RPS6KC1 DNAH17	2.99e-03	25	96	2	EFO_0003827
Disease	apolipoprotein L1 measurement	HP HPR	2.99e-03	25	96	2	EFO_0021854

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLCPRQRKMRVNVDP	BOP1	371	Q14137
YLINDIRPPCIKEQM	FAM222A	411	Q5U5X8
ACMLRYQKCLVARPP	APBB2	701	Q92870
QTLRCNPRPGKMVIY	CRYBG3	2286	Q68DQ2
NRMCPLPKRVFLAIQ	ALMS1	4091	Q8TCU4
CLLRLYKASPDLVPM	AP2A1	171	O95782
LRCVRDEGMPIYKAP	DNAJA4	301	Q8WW22
NPKRICIMRYSVPIL	DPY19L3	516	Q6ZPD9
PRAKVVRVCQALMDY	DEPDC7	91	Q96QD5
KCVLNEGMPIYRRPY	DNAJA1	301	P31689
RPGMYVRIEIENVPC	BMS1	881	Q14692
KMSCQIPQEPQRLIY	CDHR4	571	A6H8M9
YIELIPRDRKMCSQV	NWD2	566	Q9ULI1
IQKGQYMRTLRPPCE	NBEAL1	2521	Q6ZS30
LRELTVYGNPICRKM	LRRC9	1321	Q6ZRR7
MLCYNRRIPIPELEA	PMPCB	426	O75439
ICNPLRYPIIMNKVV	OR13C4	126	Q8NGS5
AICNPLRYPVVMSKA	OR13C6P	126	Q8NH95
AICNPLRYPVVMSKA	OR13C7	126	P0DN81
MLERVIKNYKRCFPV	MAGEA4	136	P43358
RVMPICLPSKDYAEV	HP	261	P00738
MKNVPVPVYCRPLVE	MAPK8IP3	686	Q9UPT6
RPRVCPKEVYDVMLG	NTRK3	791	Q16288
PRCVPNMVCLHKYII	RPS6KC1	381	Q96S38
KCNQPTPVRYRVRDM	LIPM	331	Q5VYY2
PLGPECSRAVMKLVY	GPC1	241	P35052
RSIPDYRPRKCRQMS	GALNT9	131	Q9HCQ5
NERVMPICLPSKNYA	HPR	201	P00739
QNCPIDVRRPLYKME	ACTR3C	176	Q9C0K3
RALAAPRVKLMEDPY	FER1L4	851	A9Z1Z3
CPEDPYMKIRREVVE	EFHC2	191	Q5JST6
INLSKTPQAYMCLPR	EPYC	301	Q99645
DDLKKYLEPRCPRMV	FBXO3	101	Q9UK99
YLEPRCPRMVLSLKE	FBXO3	106	Q9UK99
IKYLSQMLRDLPSCP	ISM2	416	Q6H9L7
LFYQLPVRRKCMDPR	MLH3	151	Q9UHC1
PLKRDPLQDICRRYM	PGM2L1	226	Q6PCE3
RYCAVMDPLRYPVLV	HRH2	116	P25021
PERPQLCRYDLVLME	LIPH	421	Q8WWY8
PVEKPYFPICMRLLR	MON2	301	Q7Z3U7
AICQPLRYPVLMTAK	OR10G3	126	Q8NGC4
KPLRYTVIMNPQLCT	OR12D2	126	P58182
ICNPLRYPIIMSKDA	OR13C5	126	Q8NGS8
KPLRYPTIMSQQVCI	OR4C11	126	Q6IEV9
VCRPLRYTAIMNPQL	OR2C1	126	O95371
ICNPLRYPIIMSKDA	OR13C2	126	Q8NGS9
YRKPEVCVMERRLPL	OVOS2	666	Q6IE36
VCVMERRLPLPKPLY	OVOS2	671	Q6IE36
MGRLLQLQPEPRICY	PLA2G4F	541	Q68DD2
PVLYVLTCPDMLRKL	PTGDR2	301	Q9Y5Y4
RYIAMCREKQPMVPE	MCM7	561	P33993
MPKRLCLALITGPYV	OR8H3	136	Q8N146
KPLRYTVIMNPQLCT	OR12D1	126	P0DN82
QCPIRGLYKERMTEL	PREP	56	P48147
YRRPYPVMRKICQVV	PAQR8	201	Q8TEZ7
PRAEDLRNMPYLKAC	CYP24A1	366	Q07973
IPVDRMETKNIYECP	DNAH17	4411	Q9UFH2
MVKQPRYRKGPDVCF	CACNA2D1	1046	P54289
CLMRAELIVQPELKY	DSP	81	P15924
ARPMLEGVKYLCIPA	DUSP22	41	Q9NRW4
YKEGQLTPMPREVCR	LYST	1976	Q99698
ARDICVIQVPPEMRY	MALSU1	106	Q96EH3
VMPCRAPKVGRLIYT	KEAP1	316	Q14145
DLRRLEMYCAPLKPA	IGF1	101	P05019
RRAYPAQITPKMCLL	DUS2	361	Q9NX74
PLVILMPAKFVRCAY	SLC13A5	26	Q86YT5
ICYPLRYTVIMNPRI	OR10D3	126	Q8NH80
DPKLCARPMYILLGV	OR10G2	56	Q8NGC3
VAVCNPLRYPVLMNR	OR2T11	121	Q8NH01
CSPLRYPVIMSKRLC	OR8H1	126	Q8NGG4
CKPYMAPERINPELN	MAP2K6	216	P52564
VCKPLHYVVIMNPRL	OR2G3	126	Q8NGZ4
ICNPLRYPIIMSKNA	OR13C9	126	Q8NGT0
LKPSCVYQMQRPLIK	NR4A3	71	Q92570
RYMPDICVIRAIQKI	USP9X	1231	Q93008
DPVANVRMKLCYLLP	PPP4R4	616	Q6NUP7
YDLVAVLCPKGPLRM	PSEN1	256	P49768
DFPQPCLVRVYMVRA	FER1L5	1481	A0AVI2
YGRKIIVFSACRMPP	ARHGAP1	81	Q07960
PAQLKVLTMPETCRY	PSMD1	886	Q99460
CSNIAYPRLVMKLVP	SLC5A3	346	P53794
QQMEIPLKPAYERSC	TANC2	1806	Q9HCD6
LPVKMPCLYLQTLAR	MYCBP2	3386	O75592
VCRPFLKLYQAMQPV	TNS3	196	Q68CZ2
RPLTYPVRQNGKCMA	HTR7	186	P34969
LRVELPTCMYRLPNV	AIMP2	16	Q13155
LPAKQAEYCIRRMVP	ACTN3	861	Q08043
QMKLDSILRRPYVTC	SPO11	336	Q9Y5K1
CSNIAYPRLVVKLMP	SLC5A2	361	P31639
PAMRKVLYPCRFCNQ	RREB1	636	Q92766
YQPPVTRCLRDILQM	SPIDR	626	Q14159
MACLNPVPKLYRSVI	GTF2A1L	1	Q9UNN4
NINYKRPIPLCSVVM	THEM4	181	Q5T1C6
YALRMLPKTGCVIQP	SOBP	816	A7XYQ1
PDPIKRCIYQVSCML	SPRED1	356	Q7Z699
KCPLPEMHVRIYLCR	FCMR	36	O60667
SRYMPDICVIRAIQK	USP9Y	1231	O00507
CYVKMVCLREPPQLV	TXNRD2	446	Q9NNW7
CRNGKPLPLSRSYIM	PHLPP1	1296	O60346
ALCMEQVYPIIAERP	XPO6	916	Q96QU8
YPEDAPRNMLPLVCK	VRTN	66	Q9H8Y1
RENRMNPLRCPVKFY	ZMYM3	1286	Q14202
QMLLKYILRPLASCP	ZW10	246	O43264
YMPDKLARLDPRLFC	MYO6	721	Q9UM54