Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	interleukin-1 binding	NLRP7 TRIM16 PXDN	4.48e-05	12	120	3	GO:0019966
GeneOntologyBiologicalProcess	microtubule-based process	SPAST STAG1 DYNC2H1 NEK10 CUL9 INO80 MEI1 PRC1 LYST CCDC39 KIAA0753 CEP350 HAUS4 DNAH12 BORCS5 DST TTL KLHL42 CCDC120 CFAP69 KPNB1	7.37e-07	1058	120	21	GO:0007017
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	SPAST STAG1 CUL9 INO80 MEI1 PRC1 CCDC39 KIAA0753 CEP350 HAUS4 DST TTL CCDC120 CFAP69 KPNB1	1.90e-05	720	120	15	GO:0000226
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	DCAF1 KCTD13 CUL9 PRAMEF17 FEM1C KLHL42 ZER1 PRAMEF26	3.12e-05	212	120	8	GO:0031461
GeneOntologyCellularComponent	intracellular protein-containing complex	DCAF1 KCTD13 POLD1 CUL9 MSL1 PRAMEF17 FEM1C CNOT8 BORCS5 HPS4 CNOT7 KLHL42 ZER1 CCDC120 POTEJ PRAMEF26	1.40e-04	972	120	16	GO:0140535
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF17 FEM1C ZER1 PRAMEF26	1.52e-04	47	120	4	GO:0031462
GeneOntologyCellularComponent	transferase complex	DCAF1 KCTD13 NEK10 POLD1 CUL9 MSL1 PRAMEF17 FEM1C SLF2 TBK1 KLHL42 ZER1 POTEJ PRAMEF26 KDM6A	4.12e-04	963	120	15	GO:1990234
GeneOntologyCellularComponent	CCR4-NOT core complex	CNOT8 CNOT7	4.83e-04	6	120	2	GO:0030015
GeneOntologyCellularComponent	chromosome, telomeric region	LRWD1 NLRP7 POLD1 THOC5 ORC5 SLF2	5.41e-04	176	120	6	GO:0000781
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	SPAST DYNC2H1 LMNTD2 HID1 INO80 PRC1 SPECC1 HAUS4 DNAH12 DST SHANK2 TTL POTEJ PACRG	6.50e-04	899	120	14	GO:0099513
GeneOntologyCellularComponent	nuclear origin of replication recognition complex	LRWD1 ORC5	8.95e-04	8	120	2	GO:0005664
GeneOntologyCellularComponent	origin recognition complex	LRWD1 ORC5	8.95e-04	8	120	2	GO:0000808
GeneOntologyCellularComponent	ubiquitin ligase complex	DCAF1 KCTD13 CUL9 PRAMEF17 FEM1C KLHL42 ZER1 PRAMEF26	9.78e-04	352	120	8	GO:0000151
GeneOntologyCellularComponent	microtubule	SPAST DYNC2H1 HID1 INO80 PRC1 HAUS4 DNAH12 DST TTL PACRG	1.01e-03	533	120	10	GO:0005874
GeneOntologyCellularComponent	motile cilium	DYNC2H1 PRAMEF17 CCDC39 DNAH12 DAAM1 TAS2R19 PACRG CFAP69	1.03e-03	355	120	8	GO:0031514
GeneOntologyCellularComponent	NLS-dependent protein nuclear import complex	KPNA6 KPNB1	1.43e-03	10	120	2	GO:0042564
GeneOntologyCellularComponent	spindle	SPAST STAG1 INO80 PRC1 CEP350 HAUS4 TBCK TTL KLHL42	1.60e-03	471	120	9	GO:0005819
GeneOntologyCellularComponent	pi-body	ASZ1 PIWIL2	1.74e-03	11	120	2	GO:0071546
GeneOntologyCellularComponent	nucleocytoplasmic transport complex	KPNA6 KPNB1	2.08e-03	12	120	2	GO:0031074
MousePheno	absent sperm fibrous sheath	CCDC159 CCDC183 CFAP69	1.61e-05	8	94	3	MP:0030591
Domain	ARM-like	MON2 DCAF1 STAG1 NEK10 CUL9 ARMC10 KPNA6 HEATR1 MEI1 ARID1B NBEAL2 ZER1 DAAM1 CFAP69 TARBP1 KPNB1	1.45e-11	270	118	16	IPR011989
Domain	-	LRWD1 NLRP7 SLITRK3 LINGO2 PRAMEF17 NLRC4 NLRP3 PPP1R7 SLIT2 PXDN SLIT3 PPP1R37 NLRC5 ZER1 LRRC8B DMAC2L NLRP8	1.90e-11	321	118	17	3.80.10.10
Domain	L_dom-like	LRWD1 NLRP7 SLITRK3 LINGO2 PRAMEF17 NLRC4 NLRP3 PPP1R7 SLIT2 PXDN SLIT3 PPP1R37 NLRC5 ZER1 LRRC8B DMAC2L NLRP8	2.67e-11	328	118	17	IPR032675
Domain	ARM-type_fold	MON2 DCAF1 STAG1 NEK10 CUL9 ARMC10 KPNA6 HEATR1 MEI1 LYST NBEAL2 ZER1 DAAM1 CFAP69 UNC79 TARBP1 KPNB1	4.49e-11	339	118	17	IPR016024
Domain	-	MON2 DCAF1 NEK10 CUL9 ARMC10 KPNA6 HEATR1 ARID1B ZER1 DAAM1 CFAP69 KPNB1	1.67e-08	222	118	12	1.25.10.10
Domain	Leu-rich_rpt	LRWD1 SLITRK3 LINGO2 NLRP3 PPP1R7 SLIT2 PXDN SLIT3 PPP1R37 NLRC5 LRRC8B NLRP8	1.49e-07	271	118	12	IPR001611
Domain	NACHT	NLRP7 NLRC4 NLRP3 NLRC5 NLRP8	2.84e-07	23	118	5	PS50837
Domain	NACHT_NTPase	NLRP7 NLRC4 NLRP3 NLRC5 NLRP8	2.84e-07	23	118	5	IPR007111
Domain	LRR	LRWD1 LINGO2 PPP1R7 SLIT2 PXDN SLIT3 PPP1R37 NLRC5 LRRC8B	5.26e-06	201	118	9	PS51450
Domain	LRR_1	LRWD1 SLITRK3 LINGO2 PPP1R7 SLIT2 PXDN SLIT3 NLRC5 LRRC8B	1.05e-05	219	118	9	PF00560
Domain	Leu-rich_rpt_typical-subtyp	LRWD1 SLITRK3 LINGO2 PPP1R7 SLIT2 PXDN SLIT3 LRRC8B	1.67e-05	177	118	8	IPR003591
Domain	LRR_TYP	LRWD1 SLITRK3 LINGO2 PPP1R7 SLIT2 PXDN SLIT3 LRRC8B	1.67e-05	177	118	8	SM00369
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH12 MDN1	8.51e-05	14	118	3	IPR011704
Domain	AAA_5	DYNC2H1 DNAH12 MDN1	8.51e-05	14	118	3	PF07728
Domain	ARM_REPEAT	NEK10 ARMC10 KPNA6 ZER1	1.16e-04	40	118	4	PS50176
Domain	-	POLD1 PIWIL2 CNOT8 CNOT7	2.19e-04	47	118	4	3.30.420.10
Domain	c-SKI_SMAD4-bd_dom	SKOR2 SKOR1	2.36e-04	4	118	2	IPR014890
Domain	Tscrpt_reg_SKI_SnoN	SKOR2 SKOR1	2.36e-04	4	118	2	IPR023216
Domain	c-SKI_SMAD_bind	SKOR2 SKOR1	2.36e-04	4	118	2	PF08782
Domain	c-SKI_SMAD_bind	SKOR2 SKOR1	2.36e-04	4	118	2	SM01046
Domain	Cys-rich_flank_reg_C	SLITRK3 LINGO2 SLIT2 PXDN SLIT3	2.65e-04	90	118	5	IPR000483
Domain	LRRCT	SLITRK3 LINGO2 SLIT2 PXDN SLIT3	2.65e-04	90	118	5	SM00082
Domain	AAA+_ATPase	ABCC4 SPAST DYNC2H1 DNAH12 MDN1 MCM9	3.07e-04	144	118	6	IPR003593
Domain	AAA	ABCC4 SPAST DYNC2H1 DNAH12 MDN1 MCM9	3.07e-04	144	118	6	SM00382
Domain	-	NLRP7 FAS NLRC4 NLRP3 NLRP8	3.08e-04	93	118	5	1.10.533.10
Domain	DAPIN	NLRP7 NLRP3 NLRP8	3.47e-04	22	118	3	PS50824
Domain	PYRIN	NLRP7 NLRP3 NLRP8	3.47e-04	22	118	3	PF02758
Domain	DAPIN	NLRP7 NLRP3 NLRP8	3.47e-04	22	118	3	IPR004020
Domain	PYRIN	NLRP7 NLRP3 NLRP8	3.47e-04	22	118	3	SM01289
Domain	CAF1	CNOT8 CNOT7	3.91e-04	5	118	2	PF04857
Domain	RNase_CAF1	CNOT8 CNOT7	3.91e-04	5	118	2	IPR006941
Domain	LRRNT	SLITRK3 LINGO2 SLIT2 PXDN SLIT3	3.93e-04	98	118	5	IPR000372
Domain	LRRNT	SLITRK3 LINGO2 SLIT2 PXDN SLIT3	3.93e-04	98	118	5	SM00013
Domain	LRR_6	NLRP3 PPP1R37 NLRC5 NLRP8	4.03e-04	55	118	4	PF13516
Domain	DEATH-like_dom	NLRP7 FAS NLRC4 NLRP3 NLRP8	4.12e-04	99	118	5	IPR011029
Domain	Ank_2	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	4.35e-04	215	118	7	PF12796
Domain	PH_BEACH	LYST NBEAL2	5.84e-04	6	118	2	PF14844
Domain	Ank	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	6.17e-04	228	118	7	PF00023
Domain	LRR_8	SLITRK3 LINGO2 SLIT2 PXDN SLIT3 LRRC8B	7.63e-04	171	118	6	PF13855
Domain	Ski_Sno	SKOR2 SKOR1	8.14e-04	7	118	2	PF02437
Domain	-	SKOR2 SKOR1	8.14e-04	7	118	2	3.10.260.20
Domain	Transform_Ski	SKOR2 SKOR1	8.14e-04	7	118	2	IPR003380
Domain	-	ABCC4 SPAST NLRP7 DYNC2H1 INO80 NLRC4 ORC5 DNAH12 MDN1 ERAL1 MCM9 NLRC5 NLRP8	8.69e-04	746	118	13	3.40.50.300
Domain	P-loop_NTPase	ABCC4 SPAST NLRP7 DYNC2H1 INO80 NLRC4 NLRP3 ORC5 DNAH12 MDN1 ERAL1 MCM9 NLRC5 NLRP8	9.25e-04	848	118	14	IPR027417
Domain	RNaseH-like_dom	POLD1 PIWIL2 CNOT8 CNOT7	9.54e-04	69	118	4	IPR012337
Domain	-	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	1.01e-03	248	118	7	1.25.40.20
Domain	PH-BEACH_dom	LYST NBEAL2	1.08e-03	8	118	2	IPR023362
Domain	-	LYST NBEAL2	1.08e-03	8	118	2	2.30.29.40
Domain	PH_BEACH	LYST NBEAL2	1.08e-03	8	118	2	PS51783
Domain	ANK	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	1.08e-03	251	118	7	SM00248
Domain	ANK_REPEAT	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	1.13e-03	253	118	7	PS50088
Domain	Ankyrin_rpt-contain_dom	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	1.16e-03	254	118	7	IPR020683
Domain	ANK_REP_REGION	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	1.16e-03	254	118	7	PS50297
Domain	BEACH_dom	LYST NBEAL2	1.38e-03	9	118	2	IPR000409
Domain	BEACH	LYST NBEAL2	1.38e-03	9	118	2	PS50197
Domain	Beach	LYST NBEAL2	1.38e-03	9	118	2	PF02138
Domain	-	LYST NBEAL2	1.38e-03	9	118	2	1.10.1540.10
Domain	Beach	LYST NBEAL2	1.38e-03	9	118	2	SM01026
Domain	Ankyrin_rpt	ACAP1 ASZ1 POTEG FEM1C POTEM POTEJ POTEH	1.39e-03	262	118	7	IPR002110
Domain	Leu-rich_rpt_4	LRWD1 NLRC5	1.72e-03	10	118	2	IPR025875
Domain	LRR_4	LRWD1 NLRC5	1.72e-03	10	118	2	PF12799
Domain	ARM	KPNA6 ZER1 KPNB1	2.05e-03	40	118	3	SM00185
Domain	DNA-bd_dom_put	SKOR2 SKOR1	2.10e-03	11	118	2	IPR009061
Domain	-	SKOR2 SKOR1	2.51e-03	12	118	2	3.10.390.10
Domain	SAND_dom-like	SKOR2 SKOR1	2.51e-03	12	118	2	IPR010919
Domain	WD40_repeat_dom	DCAF1 LRWD1 LYST RFWD3 ARHGEF10L NBEAL2 HERC1	2.81e-03	297	118	7	IPR017986
Domain	Armadillo	KPNA6 ZER1 KPNB1	3.26e-03	47	118	3	IPR000225
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH12	3.43e-03	14	118	2	IPR024317
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH12	3.43e-03	14	118	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH12	3.43e-03	14	118	2	PF08393
Domain	AAA_8	DYNC2H1 DNAH12	3.43e-03	14	118	2	PF12780
Domain	DHC_fam	DYNC2H1 DNAH12	3.94e-03	15	118	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH12	3.94e-03	15	118	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH12	3.94e-03	15	118	2	PF03028
Domain	LRRNT	LINGO2 SLIT2 SLIT3	4.58e-03	53	118	3	PF01462
Domain	Kelch-typ_b-propeller	KBTBD3 KLHL23 KLHL42	5.08e-03	55	118	3	IPR015915
Domain	-	DCAF1 LRWD1 LYST RFWD3 ARHGEF10L NBEAL2 HERC1	5.25e-03	333	118	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DCAF1 LRWD1 LYST RFWD3 ARHGEF10L NBEAL2 HERC1	5.42e-03	335	118	7	IPR015943
Domain	CTCK_1	SLIT2 SLIT3	5.67e-03	18	118	2	PS01185
Domain	Kelch	KBTBD3 KLHL23 KLHL42	5.89e-03	58	118	3	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KBTBD3 KLHL23 KLHL42	6.18e-03	59	118	3	IPR011043
Pathway	REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION	KPNA6 ORC5 KPNB1	1.50e-05	9	81	3	MM15358
Pathway	WP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY	ACAP1 NLRP7 NLRC4 NLRP3	8.71e-05	41	81	4	M39698
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NRIP1 SPAST STAG1 CUL9 KPNA6 EYA3 SPECC1 CNOT8 CEP350 DST FCGR1A NF2 SLF2 HPS4 LNX1 KDM6A PREX1 TARBP1 KPNB1	1.35e-07	1285	123	19	35914814
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DCAF1 LRWD1 STAG1 KPNA6 MSL1 PRC1 NRIP3 SPECC1 CNOT8 TASOR2 CEP350 PPP1R7 ORC5 HAUS4 ARID1B CNOT7 KLHL42 KPNB1	1.38e-07	1155	123	18	20360068
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 LRWD1 CUL9 INO80 LYST ARHGEF10L HAUS4 DST MDN1 SHANK2 NF2 NBEAL2 PIGW NLRC5 ZER1 HERC1 PREX1	3.81e-07	1105	123	17	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SPAST RALGAPB SPECC1 LYST KIAA0753 CEP350 BORCS5 DST MDN1 KCNQ5 SLF2 TET1 SEC24B DYRK1B DOP1A	4.18e-07	861	123	15	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SPAST INO80 FEM1C ARHGEF10L ARID1B DST NBEAL2 HPS4 TET1 SLIT3 KLHL42 DAAM1	4.22e-07	529	123	12	14621295
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEG POTEM POTEH	8.57e-07	6	123	3	17171436
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KBTBD3 NRIP1 ABCC4 RALGAPB SLITRK3 TASOR2 PXDN SHANK2 KCNQ5 NF2 TBK1 TBCK KLHL23 NLRC5 DAAM1 PACRG CFAP69 KDM6A DOP1A	1.25e-06	1489	123	19	28611215
Pubmed	Fas-mediated inflammatory response in Listeria monocytogenes infection.	FAS NLRC4 NLRP3	1.50e-06	7	123	3	23509366
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NLRP7 STAG1 MSL1 HEATR1 LYST TASOR2 TRIM16 DST MDN1 PXDN SHANK2 NOSTRIN POTEJ CFAP69 PREX1 CCDC158 DOP1A KPNB1	3.33e-06	1442	123	18	35575683
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MON2 MOSPD2 RALGAPB KPNA6 HID1 KIAA0753 CEP350 PPP1R7 ARID1B NF2 SEC24B PPP1R37 HERC1 KDM6A KPNB1	4.74e-06	1049	123	15	27880917
Pubmed	NODs: intracellular proteins involved in inflammation and apoptosis.	NLRP7 NLRP3 NLRP8	9.28e-06	12	123	3	12766759
Pubmed	Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis.	NLRC4 NLRP3	1.24e-05	2	123	2	30658261
Pubmed	Conservation of the deadenylase activity of proteins of the Caf1 family in human.	CNOT8 CNOT7	1.24e-05	2	123	2	15769875
Pubmed	Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis.	NLRC4 NLRP3	1.24e-05	2	123	2	33848452
Pubmed	The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses.	NLRC4 NLRP3	1.24e-05	2	123	2	30368901
Pubmed	NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma.	NLRC4 NLRP3	1.24e-05	2	123	2	32342103
Pubmed	Actions of the NLRP3 and NLRC4 inflammasomes overlap in bone resorption.	NLRC4 NLRP3	1.24e-05	2	123	2	34383985
Pubmed	Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.	NLRP3 NLRC5	1.24e-05	2	123	2	23815151
Pubmed	NAIP/NLRC4 inflammasome participates in macrophage responses to Trypanosoma cruzi by a mechanism that relies on cathepsin-dependent caspase-1 cleavage.	NLRC4 NLRP3	1.24e-05	2	123	2	38124741
Pubmed	Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals.	NLRC4 NLRP3	1.24e-05	2	123	2	31244842
Pubmed	CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.	CNOT8 CNOT7	1.24e-05	2	123	2	35248544
Pubmed	The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.	CNOT8 CNOT7	1.24e-05	2	123	2	19605561
Pubmed	Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.	DCAF1 NF2	1.24e-05	2	123	2	24706749
Pubmed	Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL.	SKOR2 SKOR1	1.24e-05	2	123	2	31530634
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP7 NLRP3 NLRP8	1.53e-05	14	123	3	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP7 NLRP3 NLRP8	1.53e-05	14	123	3	12563287
Pubmed	Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.	NLRC4 NLRP3 NLRC5	1.53e-05	14	123	3	26320999
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NRIP1 DYNC2H1 CNOT8 CEP350 ARID1B DNAH12 MDN1 POTEJ KDM6A PREX1 TARBP1	1.75e-05	638	123	11	31182584
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEG POTEM POTEJ	1.90e-05	15	123	3	16824795
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	LRWD1 POLD1 RALGAPB MSL1 HEATR1 INO80 SPECC1 CNOT8 ORC5 DST MDN1 PXDN SHANK2 SEC24B CNOT7 DAAM1 PREX1	2.17e-05	1497	123	17	31527615
Pubmed	Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.	NLRC4 NLRP3	3.71e-05	3	123	2	20490635
Pubmed	Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons.	SLIT2 SLIT3	3.71e-05	3	123	2	10102269
Pubmed	Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.	NLRC4 NLRP3	3.71e-05	3	123	2	24798340
Pubmed	Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.	NLRC4 NLRP3	3.71e-05	3	123	2	21118981
Pubmed	Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.	SLIT2 SLIT3	3.71e-05	3	123	2	9813312
Pubmed	Function of Slit/Robo signaling in breast cancer.	SLIT2 SLIT3	3.71e-05	3	123	2	26542734
Pubmed	Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.	NLRC4 NLRP3	3.71e-05	3	123	2	25422455
Pubmed	A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.	NLRC4 NLRP3	3.71e-05	3	123	2	22174673
Pubmed	Karyopherins and nuclear import.	KPNA6 KPNB1	3.71e-05	3	123	2	11751052
Pubmed	Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.	SLIT2 SLIT3	3.71e-05	3	123	2	16840550
Pubmed	The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.	CNOT8 CNOT7	3.71e-05	3	123	2	37767629
Pubmed	Artificial Loading of ASC Specks with Cytosolic Antigens.	NLRC4 NLRP3	3.71e-05	3	123	2	26258904
Pubmed	Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.	DYNC2H1 DNAH12	3.71e-05	3	123	2	8666668
Pubmed	Nuclear targeting of proteins: how many different signals?	KPNA6 KPNB1	3.71e-05	3	123	2	10822175
Pubmed	β-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.	NLRC4 NLRP3	3.71e-05	3	123	2	25582856
Pubmed	The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis.	NLRP3 NLRC5	3.71e-05	3	123	2	31186034
Pubmed	Aberrant expression of NLRP3, NLRC4 and NLRP6 inflammasomes in patients with primary immune thrombocytopenia.	NLRC4 NLRP3	3.71e-05	3	123	2	30802690
Pubmed	Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.	NLRC4 NLRP3	3.71e-05	3	123	2	17599094
Pubmed	Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.	CNOT8 CNOT7	3.71e-05	3	123	2	33021411
Pubmed	Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.	SLIT2 SLIT3	3.71e-05	3	123	2	24065825
Pubmed	Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma.	NLRP7 NLRP3	3.71e-05	3	123	2	37273114
Pubmed	Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.	SLIT2 SLIT3	3.71e-05	3	123	2	16162649
Pubmed	Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice.	FAS LYST	3.71e-05	3	123	2	11359810
Pubmed	Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria.	NLRC4 NLRP3	3.71e-05	3	123	2	19364881
Pubmed	Latent Upregulation of Nlrp3, Nlrc4 and Aim2 Differentiates between Asymptomatic and Symptomatic Trichomonas vaginalis Infection.	NLRC4 NLRP3	3.71e-05	3	123	2	33866944
Pubmed	G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.	NLRC4 NLRP3	3.71e-05	3	123	2	25271165
Pubmed	Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.	SLIT2 SLIT3	3.71e-05	3	123	2	10349621
Pubmed	Evaluation of NLRC4, NLRP1, and NLRP3, as Components of Inflammasomes, in Chronic Hepatitis B Virus-Infected Patients.	NLRC4 NLRP3	3.71e-05	3	123	2	27750030
Pubmed	Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.	DCAF1 NF2	3.71e-05	3	123	2	24912773
Pubmed	Conserved modularity and potential for alternate splicing in mouse and human Slit genes.	SLIT2 SLIT3	3.71e-05	3	123	2	12141424
Pubmed	Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.	NLRC4 NLRP3	3.71e-05	3	123	2	20603313
Pubmed	Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome.	NLRC4 NLRP3	3.71e-05	3	123	2	19684085
Pubmed	The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.	CNOT8 CNOT7	3.71e-05	3	123	2	27605379
Pubmed	NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins.	NLRC4 NLRP3	3.71e-05	3	123	2	38453949
Pubmed	CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.	CNOT8 CNOT7	3.71e-05	3	123	2	20065043
Pubmed	TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.	NLRP3 TBK1	3.71e-05	3	123	2	34518217
Pubmed	Cutting edge: Necrosis activates the NLRP3 inflammasome.	NLRC4 NLRP3	3.71e-05	3	123	2	19596994
Pubmed	Association of Inflammasome Components in Background Liver with Poor Prognosis After Curatively-resected Hepatocellular Carcinoma.	NLRC4 NLRP3	3.71e-05	3	123	2	28011505
Pubmed	The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.	NLRC4 NLRP3	3.71e-05	3	123	2	19362023
Pubmed	Influence of the lpr environment on the lymph node cell phenotypes in C57BL/6 nubg and nulpr chimeras.	FAS LYST	3.71e-05	3	123	2	7875735
Pubmed	Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.	MON2 DOP1A	3.71e-05	3	123	2	16301316
Pubmed	The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.	CNOT8 CNOT7	3.71e-05	3	123	2	25944446
Pubmed	TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.	NLRP3 TRIM16	3.71e-05	3	123	2	36208489
Pubmed	A role for mitochondria in NLRP3 inflammasome activation.	NLRC4 NLRP3	3.71e-05	3	123	2	21124315
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MON2 PRAMEF17 ABHD4 DST MDN1 NF2 TBCK CNOT7	4.73e-05	363	123	8	14691545
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MON2 NRIP1 DYNC2H1 CUL9 KPNA6 EYA3 HAUS4 SLF2 TBK1 POTEJ	4.80e-05	588	123	10	38580884
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MON2 DYNC2H1 POLD1 KPNA6 HEATR1 ORC5 MDN1 ERAL1 TBK1 DYRK1B	6.17e-05	606	123	10	36538041
Pubmed	Defining the membrane proteome of NK cells.	ACAP1 ABCC4 MOSPD2 POLD1 KPNA6 HEATR1 CEP350 MDN1 NF2 NBEAL2 CNOT7 DAAM1 ITPRIPL1 KPNB1	6.90e-05	1168	123	14	19946888
Pubmed	Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.	NLRC4 NLRP3	7.41e-05	4	123	2	19222370
Pubmed	Expression and roles of Slit/Robo in human ovarian cancer.	SLIT2 SLIT3	7.41e-05	4	123	2	21465248
Pubmed	Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.	NLRC4 NLRP3	7.41e-05	4	123	2	18070936
Pubmed	Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.	CNOT8 CNOT7	7.41e-05	4	123	2	11136725
Pubmed	NLRP3 recruitment by NLRC4 during Salmonella infection.	NLRC4 NLRP3	7.41e-05	4	123	2	27139490
Pubmed	Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.	NLRC4 NLRP3	7.41e-05	4	123	2	18490757
Pubmed	Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.	NLRC4 NLRP3	7.41e-05	4	123	2	21957143
Pubmed	Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan.	NLRC4 NLRP3	7.41e-05	4	123	2	20007575
Pubmed	Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.	NLRC4 NLRP3	7.41e-05	4	123	2	20333626
Pubmed	NLRP3 inflammasome mediates interleukin-1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in mice.	NLRC4 NLRP3	7.41e-05	4	123	2	28032341
Pubmed	Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract.	SLIT2 SLIT3	7.41e-05	4	123	2	16828733
Pubmed	Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome.	NLRC4 NLRP3	7.41e-05	4	123	2	18768827
Pubmed	Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA.	NLRC4 NLRP3	7.41e-05	4	123	2	26687278
Pubmed	Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection.	NLRC4 NLRP3	7.41e-05	4	123	2	21037094
Pubmed	AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.	NLRC4 NLRP3	7.41e-05	4	123	2	25775556
Pubmed	The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.	NLRC4 NLRP3	7.41e-05	4	123	2	20385749
Pubmed	Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF.	NLRC4 NLRP3	7.41e-05	4	123	2	19717512
Pubmed	Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila.	NLRC4 NLRP3	7.41e-05	4	123	2	19237518
Pubmed	Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.	NLRC4 NLRP3	7.41e-05	4	123	2	29326099
Pubmed	The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.	ASZ1 PIWIL2	7.41e-05	4	123	2	23924633
Pubmed	Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.	NLRC4 NLRP3	7.41e-05	4	123	2	20808838
Pubmed	Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.	DCAF1 NF2	7.41e-05	4	123	2	21750658
Interaction	FCHSD2 interactions	ACAP1 MSL1 CCDC120 CCDC183 LNX1 CCDC158	2.68e-06	65	122	6	int:FCHSD2
Interaction	NPTN interactions	MON2 KCTD13 STAG1 DYNC2H1 HEATR1 MDN1 NBEAL2 LNX1 TARBP1 DOP1A	7.52e-06	278	122	10	int:NPTN
GeneFamily	NLR family	NLRP7 NLRC4 NLRP3 NLRC5 NLRP8	8.92e-08	25	83	5	666
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEG POTEM POTEJ POTEH	2.86e-07	13	83	4	685
GeneFamily	Ankyrin repeat domain containing	ACAP1 ASZ1 POTEG FEM1C ANKRD18B SHANK2 POTEM POTEJ POTEH	1.65e-06	242	83	9	403
GeneFamily	SKI transcriptional corepressors	SKOR2 SKOR1	1.24e-04	4	83	2	748
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP7 NLRP3 NLRP8	1.99e-04	25	83	3	994
GeneFamily	WD repeat domain containing\|BEACH domain containing	LYST NBEAL2	7.34e-04	9	83	2	1230
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC10 KPNA6 KPNB1	1.01e-03	43	83	3	409
GeneFamily	CCR4-NOT transcription complex	CNOT8 CNOT7	1.11e-03	11	83	2	1023
GeneFamily	Armadillo repeat containing\|Importins	KPNA6 KPNB1	3.04e-03	18	83	2	596
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2B NOSTRIN	4.95e-03	23	83	2	1288
GeneFamily	PRAME family	PRAMEF17 PRAMEF26	5.38e-03	24	83	2	686
GeneFamily	WD repeat domain containing	LRWD1 LYST RFWD3 NBEAL2 HERC1	7.13e-03	262	83	5	362
Coexpression	GSE11961_FOLLICULAR_BCELL_VS_MEMORY_BCELL_DAY7_DN	ABCC4 ORC5 TCP11L2 KLHL23 TTL KLHL42 DAAM1 FASTKD3	4.86e-06	200	123	8	M9339
CoexpressionAtlas	alpha beta T cells, T.8Nve.PP, TCRb+ CD8+ CD44low CD62L high, Peyer's Patch, avg-1	HID1 ALS2CL TASOR2 CEP350 MDN1 TCP11L2 TET1 NLRC5 HERC1 DOP1A	1.72e-05	336	117	10	GSM538413_500
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEK10 ITGA2 SPECC1 CCDC39 TASOR2 DNAH12 CFAP69	6.03e-07	176	123	7	87de432c680b80555342afac864599bbc002c040
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 CCDC39 DNAH12 SHANK2 PACRG CFAP69	8.43e-07	185	123	7	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACAP1 HID1 NLRC5 UNC79 PREX1 TARBP1	5.55e-06	160	123	6	6b0faaa371650563f585722f5b2fb319e124ec38
ToppCell	390C-Endothelial_cells-Endothelial-E-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ITGA2 ALS2CL PXDN NOSTRIN ACKR1 UNC79	1.02e-05	178	123	6	804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell	390C-Endothelial_cells-Endothelial-E\|390C / Donor, Lineage, Cell class and subclass (all cells)	ITGA2 ALS2CL PXDN NOSTRIN ACKR1 UNC79	1.02e-05	178	123	6	ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	ACAP1 ARID1B BORCS5 SRGAP2B HERC1 KDM6A	1.12e-05	181	123	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.31e-05	186	123	6	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DYNC2H1 GRIK4 FAS SLIT2 DST SLIT3	1.43e-05	189	123	6	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MON2 ABCC4 HEATR1 LYST MCM9 TBCK	1.52e-05	191	123	6	9454f642c3621370fa23640b631301346b300950
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MON2 ARID1B TCP11L2 TBCK DAAM1 KDM6A	1.57e-05	192	123	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 SHANK2 PACRG CFAP69	1.57e-05	192	123	6	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.62e-05	193	123	6	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 ITGA2 CCDC39 ANKRD18B CFAP69	1.62e-05	193	123	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.66e-05	194	123	6	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 SHANK2 PACRG CFAP69	1.66e-05	194	123	6	958e648138676d46698090b4046cb484083ae449
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 NEK10 CCDC39 ANKRD18B DNAH12 CFAP69	1.66e-05	194	123	6	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 SHANK2 PACRG CFAP69	1.71e-05	195	123	6	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 SHANK2 PACRG CFAP69	1.71e-05	195	123	6	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	S100Z LYST NLRC4 NLRP3 FCGR1A PREX1	1.71e-05	195	123	6	10ce1b6961f10372d1f65388cbf3626a5fcd6840
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 SHANK2 PACRG CFAP69	1.71e-05	195	123	6	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.71e-05	195	123	6	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.71e-05	195	123	6	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	BL-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.71e-05	195	123	6	07a6bcef6af93ed87df455dee624037cb75e011a
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.76e-05	196	123	6	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.76e-05	196	123	6	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 SHANK2 PACRG CFAP69	1.76e-05	196	123	6	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DYNC2H1 NRIP3 SLIT2 DST SLIT3 CFAP69	1.81e-05	197	123	6	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.81e-05	197	123	6	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.81e-05	197	123	6	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 NEK10 CCDC39 DNAH12 SHANK2 CFAP69	1.81e-05	197	123	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.81e-05	197	123	6	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.81e-05	197	123	6	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG CFAP69	1.87e-05	198	123	6	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 SHANK2 KCNQ5 HERC1 UNC79 TARBP1	1.87e-05	198	123	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MON2 STAG1 ARID1B SHANK2 HERC1 KDM6A	1.92e-05	199	123	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	DYNC2H1 NEK10 ANKRD18B DNAH12 PACRG CFAP69	1.97e-05	200	123	6	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	LINGO2 SHANK2 KCNQ5 HERC1 UNC79 TARBP1	1.97e-05	200	123	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_B2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	HID1 ALS2CL CCDC39 ANKRD18B LNX1	5.51e-05	147	123	5	b2196046656157d7fcf5b5d1cec7bf521b1e5d8e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMNTD2 PIWIL2 SPECC1 LYST CCDC158	5.88e-05	149	123	5	48fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	INO80 S100Z PXDN ERAL1 TTL	7.99e-05	159	123	5	1472536eea61d4f13033efe42f128bae1614fa74
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABCC4 HID1 ITGA2 PRC1 CEP350	7.99e-05	159	123	5	ba82d1f55dd77c4b2183981b76cab1480fba75ad
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	NEK10 CCDC39 ANKRD18B DNAH12 PACRG	9.25e-05	164	123	5	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	DCAF1 KIAA0753 ARID1B TCP11L2 CFAP69	9.79e-05	166	123	5	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	lung-Ciliated_Epithelia\|lung / shred on tissue and cell subclass	DYNC2H1 NEK10 CCDC39 DNAH12 CFAP69	1.01e-04	167	123	5	26cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell	VE-Treg-exh_CD4\|VE / Condition, Cell_class and T cell subcluster	NEK10 ITGA2 S100Z THOC5 ITPRIPL1	1.01e-04	167	123	5	1036ac1ef9440612500137af9d1929672b077e4d
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF1 POLD1 MDN1 TET1 ITPRIPL1	1.25e-04	175	123	5	bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 ALS2CL SLIT2 SLIT3 LNX1	1.36e-04	178	123	5	ccea3c8908d72f5fecd151a133048c8e9758304c
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	FBLN7 NLRC4 NLRP3 PXDN FCGR1A	1.39e-04	179	123	5	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NEK10 CCDC39 DNAH12 PACRG CCDC158	1.43e-04	180	123	5	5c9d2d44d840cd4ec7d42d43446ba2b689e7ec43
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NEK10 CCDC39 DNAH12 PACRG CCDC158	1.43e-04	180	123	5	c60e74fbbd815a0251253a19dc520a254b2e1762
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP3 KLHL23 LRRC8B DAAM1 NOSTRIN	1.47e-04	181	123	5	1db1eb7d330a7e5090994007ae287e11f0a74450
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP3 KLHL23 LRRC8B DAAM1 NOSTRIN	1.47e-04	181	123	5	06174ce9240c9261c0f51a1b0d875335d60722e5
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7\|TCGA-Prostate / Sample_Type by Project: Shred V9	KCTD13 PRC1 PIGW TARBP1 KPNB1	1.51e-04	182	123	5	af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 NEK10 CCDC39 DNAH12 CFAP69	1.58e-04	184	123	5	2df903924df9cb71039159416bcbe6a6614e21fe
ToppCell	Ciliated_cells-B-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DYNC2H1 NEK10 CCDC39 DNAH12 CFAP69	1.63e-04	185	123	5	f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell	Control-T_cells-NK_cells\|Control / group, cell type (main and fine annotations)	NLRP7 LINGO2 KCNQ5 NLRC5 PREX1	1.63e-04	185	123	5	755c0998c729f462399f1d5e88adf4bfae31be30
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 SLIT2 DST DAAM1 PACRG	1.67e-04	186	123	5	a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NEK10 CCDC39 DNAH12 PACRG CFAP69	1.67e-04	186	123	5	85787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell	Ciliated_cells-B-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.71e-04	187	123	5	2b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ACAP1 HEATR1 ARID1B KCNQ5 PPP1R37	1.71e-04	187	123	5	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	21-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	NEK10 CCDC39 DNAH12 PACRG CFAP69	1.71e-04	187	123	5	1a2178a195d078d1963947b327c6d0d4f2f48341
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MON2 TASOR2 ARID1B HERC1 KDM6A	1.75e-04	188	123	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	343B-Lymphocytic-ILC-ILC-1\|343B / Donor, Lineage, Cell class and subclass (all cells)	HEATR1 TASOR2 CCDC159 TET1 LRRC8B	1.75e-04	188	123	5	8f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell	21-Trachea-Epithelial-Multiciliated_cell\|Trachea / Age, Tissue, Lineage and Cell class	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.75e-04	188	123	5	803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.75e-04	188	123	5	82c006f43c93f4a867953a446864f02b44536a23
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.75e-04	188	123	5	da59b5c0a4b11690a39a964c1a0a83e66aa0972b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 SLIT2 DST DAAM1 PACRG	1.75e-04	188	123	5	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-F_(Ciliated)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.75e-04	188	123	5	5ba5cbb403518026e9040379fb5d99339ea977d8
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.80e-04	189	123	5	57ab947b81dbd9d3e896be89e28c4a62cf720837
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.80e-04	189	123	5	ebc16b8eab84167d74446783d7e802acedc6b9c6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLITRK3 SPECC1 SLIT2 DST KCNQ5	1.84e-04	190	123	5	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.84e-04	190	123	5	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)\|343B / Donor, Lineage, Cell class and subclass (all cells)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.84e-04	190	123	5	169e600e95878000acf5d11f813f9028c7249646
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	MON2 ORC5 HAUS4 NLRC5 ITPRIPL1	1.84e-04	190	123	5	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.84e-04	190	123	5	0cc36117c793d83cf4a1f66f47758a07d6712bd3
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.84e-04	190	123	5	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLITRK3 SPECC1 SLIT2 DST KCNQ5	1.84e-04	190	123	5	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NEK10 CCDC39 DNAH12 PACRG CFAP69	1.88e-04	191	123	5	2a8e6d560907e71e9f6e190ca0667da804e25641
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEK10 CCDC39 DNAH12 PACRG CFAP69	1.88e-04	191	123	5	46c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	MOSPD2 FEM1C BORCS5 MCM9 ZER1	1.88e-04	191	123	5	d7920f4a602b50d0ef064eb47001e71939695ed2
ToppCell	Mild_COVID-19-Epithelial-Ciliated\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	NEK10 CCDC39 DNAH12 PACRG CFAP69	1.88e-04	191	123	5	995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEK10 CCDC39 DNAH12 PACRG CFAP69	1.88e-04	191	123	5	a37f20172b85566b9039254a89680e37fd503fd5
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NEK10 CCDC39 DNAH12 PACRG CFAP69	1.88e-04	191	123	5	2d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACAP1 LINGO2 GRIK4 KCNQ5 NLRC5	1.88e-04	191	123	5	6345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GRIK4 ITGA2 SLIT2 DST SLIT3	1.88e-04	191	123	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DYNC2H1 NEK10 DNAH12 PACRG CFAP69	1.88e-04	191	123	5	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GRIK4 ITGA2 SLIT2 DST SLIT3	1.93e-04	192	123	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	MS-Treg-exh_CD4\|MS / Condition, Cell_class and T cell subcluster	STAG1 MSL1 BORCS5 SLF2 ZER1	1.93e-04	192	123	5	c6722bf142c84ccedd99c1a3344085aecb4cbab4
ToppCell	multiciliated\|World / shred by cell class for turbinate	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.93e-04	192	123	5	0f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRWD1 NEK10 CCDC39 DNAH12 PACRG	1.93e-04	192	123	5	1b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 PACRG CFAP69	1.93e-04	192	123	5	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	Bronchial_Brush\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.98e-04	193	123	5	3e693ac4c92576e3f2c9efdd3f1d96d3d336e260
ToppCell	15-Trachea-Epithelial-Multiciliated_cell\|Trachea / Age, Tissue, Lineage and Cell class	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	1.98e-04	193	123	5	aa3acc7571405169efb656d214f3a8cbf988362e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DYNC2H1 NEK10 DNAH12 PACRG CFAP69	1.98e-04	193	123	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	MON2 ARID1B TCP11L2 TBCK KDM6A	1.98e-04	193	123	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACAP1 LINGO2 GRIK4 KCNQ5 PREX1	1.98e-04	193	123	5	1cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	2.03e-04	194	123	5	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GRIK4 SLIT2 DST SLF2 SLIT3	2.03e-04	194	123	5	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 NEK10 CCDC39 DNAH12 PACRG	2.03e-04	194	123	5	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GRIK4 SPECC1 DST SLIT3 DAAM1	2.03e-04	194	123	5	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
Drug	Levocabastine hydrochloride [79547-78-7]; Down 200; 8.8uM; HL60; HT_HG-U133A	SPAST KCTD13 DYNC2H1 RALGAPB FAS NLRP3 PPP1R7 NF2 DMAC2L	1.35e-06	200	122	9	2948_DN
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	NRIP1 SPAST STAG1 CEP350 MDN1 SEC24B LRRC8B DAAM1	6.59e-06	183	122	8	7498_DN
Drug	tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA	NRIP1 CEP350 MDN1 TBK1 SEC24B LRRC8B DAAM1 DOP1A	7.14e-06	185	122	8	1114_DN
Drug	0198306-0000 [212631-61-3]; Down 200; 10uM; PC3; HT_HG-U133A	DCAF1 STAG1 DYNC2H1 ARHGEF10L CNOT8 NF2 HPS4 LRRC8B	1.13e-05	197	122	8	7069_DN
Disease	male infertility (biomarker_via_orthology)	FAS CNOT7	4.20e-05	3	111	2	DOID:12336 (biomarker_via_orthology)
Disease	amino acid measurement	ABCC4 STAG1 LINGO2 ITGA2 SLIT2 ORC5 DNAH12 PXDN MCM9 SLIT3 TTL	5.14e-05	678	111	11	EFO_0005134
Disease	Malignant neoplasm of breast	NRIP1 ACAP1 SPAST DYNC2H1 PRC1 FEM1C ALS2CL THOC5 ARID1B NF2 NLRC5 FASTKD3 DOP1A NLRP8	5.19e-05	1074	111	14	C0006142
Disease	Cryopyrin-Associated Periodic Syndromes	NLRC4 NLRP3	8.37e-05	4	111	2	C2316212
Disease	Chronic Infantile Neurological, Cutaneous, and Articular Syndrome	NLRC4 NLRP3	8.37e-05	4	111	2	C0409818
Disease	gestational trophoblastic neoplasm (is_implicated_in)	NLRP7 MEI1	8.37e-05	4	111	2	DOID:3590 (is_implicated_in)
Disease	Familial Cold Autoinflammatory Syndrome 1	NLRC4 NLRP3	8.37e-05	4	111	2	C4551895
Disease	Familial cold urticaria	NLRC4 NLRP3	8.37e-05	4	111	2	C0343068
Disease	Familial cold autoinflammatory syndrome	NLRC4 NLRP3	8.37e-05	4	111	2	cv:C0343068
Disease	Complete hydatidiform mole	NLRP7 MEI1	8.37e-05	4	111	2	C0678213
Disease	Muckle-Wells Syndrome	NLRC4 NLRP3	1.39e-04	5	111	2	C0268390
Disease	Hereditary Autoinflammatory Diseases	NLRC4 NLRP3	2.91e-04	7	111	2	C0751422
Disease	asphyxiating thoracic dystrophy (is_implicated_in)	DYNC2H1 KIAA0753	2.91e-04	7	111	2	DOID:0050592 (is_implicated_in)
Disease	Myopia	NRIP1 RFWD3 ARID1B KCNQ5 TCP11L2 ZER1 NLRP8	6.48e-04	385	111	7	HP_0000545
Disease	pulse pressure measurement	NRIP1 DYNC2H1 NEK10 INO80 MEI1 FAS KIAA0753 ARID1B KCNQ5 TET1 SLIT3 KLHL42 LNX1 CFAP69	7.39e-04	1392	111	14	EFO_0005763
Disease	nervous system disease (implicated_via_orthology)	SKOR2 SKOR1	9.03e-04	12	111	2	DOID:863 (implicated_via_orthology)
Disease	11beta-hydroxyandrosterone glucuronide measurement	SPAST NLRC4	9.03e-04	12	111	2	EFO_0800573
Disease	alpha-hydroxybutyric acid measurement	ABCC4 NOSTRIN	9.03e-04	12	111	2	EFO_0010458
Disease	urinary nitrogen measurement	POLD1 SPECC1	1.24e-03	14	111	2	EFO_0005190
Disease	Kartagener syndrome (implicated_via_orthology)	CCDC39 SLIT2	1.24e-03	14	111	2	DOID:0050144 (implicated_via_orthology)
Disease	malignant pleural mesothelioma (is_marker_for)	NF2 KDM6A	1.24e-03	14	111	2	DOID:7474 (is_marker_for)
Disease	Down syndrome (implicated_via_orthology)	DYRK1B DOP1A	1.43e-03	15	111	2	DOID:14250 (implicated_via_orthology)
Disease	platelet storage pool deficiency (implicated_via_orthology)	LYST HPS4	1.43e-03	15	111	2	DOID:2223 (implicated_via_orthology)
Disease	dermatomyositis (is_marker_for)	FAS SLIT2	1.84e-03	17	111	2	DOID:10223 (is_marker_for)
Disease	age at menarche	KCTD13 MYO1H INO80 DST SKOR2 SLIT3 NOSTRIN UNC79	1.85e-03	594	111	8	EFO_0004703
Disease	alcoholic hepatitis (biomarker_via_orthology)	FAS NLRP3	2.06e-03	18	111	2	DOID:12351 (biomarker_via_orthology)
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	KCTD13 STAG1 LINGO2 TET1 SKOR1 UNC79	2.59e-03	364	111	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	interleukin 18 measurement	SPAST NLRC4 NOSTRIN	2.98e-03	76	111	3	EFO_0004581
Disease	Self-injurious behavior	LINGO2 ARID1B DAAM1	3.21e-03	78	111	3	HP_0100716
Disease	airway responsiveness measurement	ABCC4 LINGO2	3.67e-03	24	111	2	EFO_0006897
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	SLIT2 SLIT3	3.67e-03	24	111	2	DOID:3827 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALQQKRETLSPLCLI	KCTD13	136	Q8WZ19
CLRLLQQLHKSSQQL	ALS2CL	46	Q60I27
LNKLLTSGQRQLLLC	ARHGEF10L	526	Q9HCE6
VQVVTLLLDRKCQIN	ANKRD18B	81	A2A2Z9
REKLLNIQQQLTCSL	SPECC1	481	Q5M775
SQLKNVEARILQCLQ	ABHD4	26	Q8TB40
VRSKLLLLSTCLAQQ	ACKR1	266	Q16570
LLLSTCLAQQALDLL	ACKR1	271	Q16570
STLQSQLLKVLQRLI	DOP1A	1576	Q5JWR5
KSCLLQADSERLLQL	ACAP1	336	Q15027
LCKLSIQDNNVDLIL	ARID1B	2156	Q8NFD5
CLLRLSQLENLQKTI	DMAC2L	141	Q99766
LNLTRKLAQQLCTAL	DYRK1B	211	Q9Y463
ILLRVLTLFQNIKNC	ARMC10	276	Q8N2F6
EQILKCVELLLSRNA	ASZ1	126	Q8WWH4
LQLERLTLECNQKRK	CCDC39	176	Q9UFE4
ALNLRNRQVICVTLK	PACRG	156	Q96M98
LQLQVLTDKCTRLQR	RFWD3	381	Q6PCD5
SLLLIQSRKNCVNVL	EYA3	466	Q99504
KILLQFQCRNRLLLT	INO80	666	Q9ULG1
IKSINLVNCLQLLSI	KBTBD3	146	Q8NAB2
KLLCRLTQLQELDLS	LRWD1	41	Q9UFC0
LQLNKALSIILHLIC	FEM1C	436	Q96JP0
NCLSKQQLLSAIRQL	FBLN7	26	Q53RD9
FLKLSCVQLLLQLIS	DCAF1	591	Q9Y4B6
LNCSILNPLLTLLTK	KPNA6	206	O60684
RQCVLSTLAQLLLDK	MDN1	41	Q9NU22
LKDCQIQDSQLRVLL	PRAMEF17	356	Q5VTA0
LLLQIQKSRCLRNLM	NLRC4	321	Q9NPP4
QCKLQKLLLRRVNST	NLRP8	731	Q86W28
QLLRLLNTTQKCFLD	DST	3596	Q03001
LCRIKSLQTRVDQIL	KCNQ5	561	Q9NR82
RLLACKNLELIQTRS	HERC1	1306	Q15751
LLDLLCSQLKNLLSQ	HERC1	1841	Q15751
AKLLVQLCTQNLISA	HERC1	3281	Q15751
LLLLKAARILQTCQR	HPS4	171	Q9NQG7
LLRTLKQCQTLREAL	KDM6A	1296	O15550
LSLKLQELRKVCLQE	CCDC120	46	Q96HB5
RLRCLLNVQSSKQQL	NEK10	31	Q6ZWH5
TRNQLSPQLLRCLTK	ERAL1	211	O75616
NLNELQKIIILRCLR	DNAH12	2441	Q6ZR08
SILVNKLLNKLLVTC	LNX1	91	Q8TBB1
LKQLLLSENCVRDLS	NRIP1	936	P48552
LLSLEQLTLEKCNLT	LINGO2	176	Q7L985
LQNLQKSCLLQLARS	LMNTD2	156	Q8IXW0
RLKQLECVLQILQSQ	MON2	881	Q7Z3U7
SSQAACLKQILLLQL	MSL1	216	Q68DK7
ITLVNKNAQIILKLC	ITGA2	666	P17301
QSLKRNCLIVEENLL	LRRC8B	771	Q6P9F7
QSRSLTLRLQKCQLQ	NLRC5	841	Q86WI3
NSSKLRVNKLILQLC	NF2	286	P35240
ITTQLKLEQTIRCLL	MEI1	121	Q5TIA1
TKELQINCLGLLRQL	MEI1	236	Q5TIA1
LLKFNCSLQILDLRN	PPP1R37	271	O75864
CLARAILRKNQILII	ABCC4	1186	O15439
KCLQIILSLRQHQSL	ITPRIPL1	421	Q6GPH6
CNILLSRLKLSNDEI	DAAM1	696	Q9Y4D1
LLTILDQLQRCQKSL	DYNC2H1	1401	Q8NCM8
RCNVDLLKIIQLGLT	CNOT7	66	Q9UIV1
LQRSCLLTENKIRSL	KLHL23	241	Q8NBE8
LEKLDSQQVLQLCLR	BORCS5	81	Q969J3
LKTITQLQEQCRALQ	CCDC183	16	Q5T5S1
CTPLLDLLTREKNQL	CEP350	2716	Q5VT06
NALLLLLQILNSCSK	LYST	2446	Q99698
QSLLCATLQNVLRKV	KPNB1	581	Q14974
NLVTLSCETKLLLQR	FCGR1A	206	P12314
EQKRNLLSCLLVRIL	CUL9	1866	Q8IWT3
RCNVDLLKIIQLGLT	CNOT8	66	Q9UFF9
LSCLIVLLQRQKPES	HEATR1	301	Q9H583
CRKLQNRLESLQTLV	CCDC158	1066	Q5M9N0
QVLLRCLTLLQRLLQ	HAUS4	236	Q9H6D7
CLLNLEKLLRQFLIS	GRIK4	171	Q16099
VIQQLSNLECLLALK	CFAP69	276	A5D8W1
KTLCLRQNLIKCIEN	PPP1R7	101	Q15435
LTILCQSLLENLDKL	SEC24B	696	O95487
LLCNRIDISQLVITK	POLD1	871	P28340
LENLLSHTIILKNLC	PRAMEF26	301	H0Y7S4
LLRCELESLKSQLQA	CCDC159	31	P0C7I6
SILELEKERIQLLCN	NOSTRIN	211	Q8IVI9
QCELILEKLELQSLL	MCM9	631	Q9NXL9
LSCKISQQIRLELLK	NLRP3	596	Q96P20
LGLQTLRSLKCIINL	NRIP3	196	Q9NQ35
CLQLSRLLESNRKLE	MOSPD2	471	Q8NHP6
NLRTQQSKLVLLLCQ	TAS2R19	251	P59542
ERLCLAQISNTLLKN	SKOR1	96	P84550
LFSCINLLRLLNKLT	STRIP2	661	Q9ULQ0
LNQLKIIACLSLITN	TCP11L2	336	Q8N4U5
RSVAQKILLQINCKL	PIWIL2	711	Q8TC59
CFTLRLLLEQILNKL	ORC5	66	O43913
LLLNLVAECQNRLRK	FASTKD3	196	Q14CZ7
LLKLFIILCRNLENI	NBEAL2	81	Q6ZNJ1
KQIVLNCSRLLTRVL	HID1	91	Q8IV36
NLSKLRVLILNDNLI	SLITRK3	171	O94933
SLENIATLQKLLRQL	PRC1	211	O43663
VVKLLLDRRCQLNVL	POTEJ	151	P0CG39
QLLLALLKCTDTELQ	PREX1	1306	Q8TCU6
LQRCQQLQSRLSTLK	SRGAP2B	366	P0DMP2
KLQTLVLQQCSITKL	NLRP7	876	Q8WX94
RQLRQCLSLVIISKL	SLF2	1011	Q8IX21
EETRLLLLKNLLCKQ	SPAST	511	Q9UBP0
LLEVQRLQKELSSCI	KIAA0753	216	Q2KHM9
PSLCLITALNRKQLI	PIGW	436	Q7Z7B1
RILCTLTQSLKDVLN	SHANK2	86	Q9UPX8
SLNKVIPDLNLRNCL	TET1	301	Q8NFU7
LQLLLLNANKINCLR	SLIT3	381	O75094
RCNQLLRALKLVITA	ZER1	386	Q7Z7L7
ANLCTLAEKIQTIIL	FAS	301	P25445
QLTQIKQTSLARILC	PXDN	1261	Q92626
LLLQRELTEFLSCQK	S100Z	36	Q8WXG8
RNQLTFLLLLLEKCQ	SRRD	156	Q9UH36
KIQCAKTLILSLQQL	STAG1	916	Q8WVM7
LLLLNANKINCLRVD	SLIT2	376	O94813
VTLSLCQLRNRLKDV	TBCK	381	Q8TEA7
SQIRLCLQVLRAIQK	RALGAPB	136	Q86X10
RLCLAQISNTLLKNF	SKOR2	61	Q2VWA4
LQCTQLDLERKLKLN	TRIM16	176	O95361
TKAEILKCLLNLQIQ	TASOR2	2366	Q5VWN6
LKTDRCLQLLLKLLN	TARBP1	686	Q13395
LLTNQLQRLCVLLDV	THOC5	621	Q13769
LLLDRRCQLNILDNK	POTEG	191	Q6S5H5
VKLLLDRRCQLNILD	POTEH	226	Q6S545
LLLDRRCQLNILDNK	POTEM	191	A6NI47
SSILLQIKHIIRNCL	TTL	281	Q8NG68
LRKQLLSLTNQCFDI	TBK1	626	Q9UHD2
TVTQLKEGLNRILCL	UNC79	596	Q9P2D8
SLLQLLLSQVRLNNC	KLHL42	116	Q9P2K6
CNEKLQQLLIERTLK	MYO1H	411	Q8N1T3