Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DHX16 DDX23 ACIN1 EFL1 CRACR2A SRCAP ATAD2 DDX54	8.63e-05	775	38	8	GO:0017111
GeneOntologyMolecularFunction	ATP-dependent activity	DHX16 DDX23 ACIN1 SRCAP ATAD2 DNAH17 DDX54	1.38e-04	614	38	7	GO:0140657
GeneOntologyMolecularFunction	pyrophosphatase activity	DHX16 DDX23 ACIN1 EFL1 CRACR2A SRCAP ATAD2 DDX54	1.50e-04	839	38	8	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DHX16 DDX23 ACIN1 EFL1 CRACR2A SRCAP ATAD2 DDX54	1.51e-04	840	38	8	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DHX16 DDX23 ACIN1 EFL1 CRACR2A SRCAP ATAD2 DDX54	1.51e-04	840	38	8	GO:0016818
GeneOntologyMolecularFunction	ATP hydrolysis activity	DHX16 DDX23 ACIN1 SRCAP ATAD2 DDX54	1.70e-04	441	38	6	GO:0016887
GeneOntologyMolecularFunction	helicase activity	DHX16 DDX23 SRCAP DDX54	2.26e-04	158	38	4	GO:0004386
GeneOntologyMolecularFunction	RNA helicase activity	DHX16 DDX23 DDX54	4.38e-04	78	38	3	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DHX16 DDX23 DDX54	4.72e-04	80	38	3	GO:0008186
GeneOntologyMolecularFunction	molecular adaptor activity	BCLAF3 DHX16 PHF14 ACTN4 SORBS1 TCHH ZZZ3 SRCAP DDX54	8.08e-04	1356	38	9	GO:0060090
GeneOntologyMolecularFunction	histone reader activity	PHF14 ZZZ3	1.11e-03	26	38	2	GO:0140566
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	BCLAF3 PHF14 ACTN4 SORBS1 TCHH ZZZ3 SRCAP DDX54	1.30e-03	1160	38	8	GO:0030674
GeneOntologyMolecularFunction	histone binding	PHF14 ZZZ3 SRCAP ATAD2	1.57e-03	265	38	4	GO:0042393
GeneOntologyMolecularFunction	bHLH transcription factor binding	USF1 USF2	2.25e-03	37	38	2	GO:0043425
GeneOntologyMolecularFunction	chromatin-protein adaptor activity	PHF14 ZZZ3	2.76e-03	41	38	2	GO:0140463
GeneOntologyBiologicalProcess	late viral transcription	USF1 USF2	1.87e-05	4	37	2	GO:0019086
GeneOntologyBiologicalProcess	positive regulation of transcription from RNA polymerase II promoter by glucose	USF1 USF2	6.54e-05	7	37	2	GO:0000432
GeneOntologyBiologicalProcess	positive regulation of transcription by glucose	USF1 USF2	8.71e-05	8	37	2	GO:0046016
GeneOntologyBiologicalProcess	regulation of transcription from RNA polymerase II promoter by glucose	USF1 USF2	8.71e-05	8	37	2	GO:0000430
GeneOntologyBiologicalProcess	carbon catabolite activation of transcription from RNA polymerase II promoter	USF1 USF2	8.71e-05	8	37	2	GO:0000436
GeneOntologyBiologicalProcess	carbon catabolite regulation of transcription from RNA polymerase II promoter	USF1 USF2	1.12e-04	9	37	2	GO:0000429
GeneOntologyBiologicalProcess	carbon catabolite activation of transcription	USF1 USF2	1.12e-04	9	37	2	GO:0045991
GeneOntologyBiologicalProcess	carbon catabolite regulation of transcription	USF1 USF2	1.40e-04	10	37	2	GO:0045990
GeneOntologyBiologicalProcess	regulation of transcription by glucose	USF1 USF2	2.04e-04	12	37	2	GO:0046015
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	WT1 FSIP2 SPEF2 DNAH17	5.30e-04	210	37	4	GO:0060294
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	WT1 FSIP2 SPEF2 DNAH17	5.79e-04	215	37	4	GO:0001539
GeneOntologyBiologicalProcess	cilium-dependent cell motility	WT1 FSIP2 SPEF2 DNAH17	5.79e-04	215	37	4	GO:0060285
MousePheno	sporadic seizures	CACNA1A USF1 USF2	2.79e-05	27	31	3	MP:0000951
MousePheno	pericardial effusion	WT1 ACTN4 MYO18B CYP51A1	1.00e-04	111	31	4	MP:0005312
Domain	P-loop_NTPase	DHX16 DDX23 EFL1 MYO18B SRCAP ATAD2 HS6ST3 SPEF2 DDX54	2.45e-05	848	36	9	IPR027417
Domain	Helicase_C	DHX16 DDX23 SRCAP DDX54	5.21e-05	107	36	4	PF00271
Domain	HELICc	DHX16 DDX23 SRCAP DDX54	5.21e-05	107	36	4	SM00490
Domain	Helicase_C	DHX16 DDX23 SRCAP DDX54	5.40e-05	108	36	4	IPR001650
Domain	-	MYCL NHLH1 USF1 USF2	5.60e-05	109	36	4	4.10.280.10
Domain	HELICASE_CTER	DHX16 DDX23 SRCAP DDX54	5.60e-05	109	36	4	PS51194
Domain	HELICASE_ATP_BIND_1	DHX16 DDX23 SRCAP DDX54	5.60e-05	109	36	4	PS51192
Domain	DEXDc	DHX16 DDX23 SRCAP DDX54	5.60e-05	109	36	4	SM00487
Domain	Helicase_ATP-bd	DHX16 DDX23 SRCAP DDX54	5.80e-05	110	36	4	IPR014001
Domain	HLH	MYCL NHLH1 USF1 USF2	6.01e-05	111	36	4	PF00010
Domain	HLH	MYCL NHLH1 USF1 USF2	7.14e-05	116	36	4	SM00353
Domain	BHLH	MYCL NHLH1 USF1 USF2	7.38e-05	117	36	4	PS50888
Domain	bHLH_dom	MYCL NHLH1 USF1 USF2	7.63e-05	118	36	4	IPR011598
Domain	DEAD	DHX16 DDX23 DDX54	3.73e-04	73	36	3	PF00270
Domain	DEAD/DEAH_box_helicase_dom	DHX16 DDX23 DDX54	3.73e-04	73	36	3	IPR011545
Domain	-	DHX16 DDX23 EFL1 SRCAP ATAD2 SPEF2 DDX54	4.78e-04	746	36	7	3.40.50.300
Domain	DEAD_ATP_HELICASE	DDX23 DDX54	1.62e-03	31	36	2	PS00039
Domain	RNA-helicase_DEAD-box_CS	DDX23 DDX54	1.84e-03	33	36	2	IPR000629
Domain	EF-hand-dom_pair	ACTN4 TCHH CRACR2A SPEF2	2.18e-03	287	36	4	IPR011992
Domain	RNA_helicase_DEAD_Q_motif	DDX23 DDX54	2.31e-03	37	36	2	IPR014014
Domain	Q_MOTIF	DDX23 DDX54	2.31e-03	37	36	2	PS51195
Domain	EF_Hand_1_Ca_BS	ACTN4 TCHH CRACR2A	4.60e-03	175	36	3	IPR018247
Domain	Zinc_finger_PHD-type_CS	PHF14 PHF3	6.96e-03	65	36	2	IPR019786
Domain	EF_HAND_1	ACTN4 TCHH CRACR2A	7.03e-03	204	36	3	PS00018
Domain	CH	ACTN4 SPEF2	8.71e-03	73	36	2	PS50021
Domain	PHD	PHF14 PHF3	9.18e-03	75	36	2	PF00628
Domain	CH-domain	ACTN4 SPEF2	9.18e-03	75	36	2	IPR001715
Domain	EF_HAND_2	ACTN4 TCHH CRACR2A	9.87e-03	231	36	3	PS50222
Domain	EF_hand_dom	ACTN4 TCHH CRACR2A	9.99e-03	232	36	3	IPR002048
Domain	Znf_PHD-finger	PHF14 PHF3	1.01e-02	79	36	2	IPR019787
Domain	PHD	PHF14 PHF3	1.27e-02	89	36	2	SM00249
Domain	Znf_PHD	PHF14 PHF3	1.33e-02	91	36	2	IPR001965
Domain	-	ACTN4 TCHH CRACR2A	1.37e-02	261	36	3	1.10.238.10
Domain	ZF_PHD_2	PHF14 PHF3	1.44e-02	95	36	2	PS50016
Domain	ZF_PHD_1	PHF14 PHF3	1.47e-02	96	36	2	PS01359
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DHX16 DDX23 ACIN1 ZFR ACTN4 SORBS1 ZZZ3 SRCAP PHF3	3.05e-09	506	38	9	30890647
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DDX23 ACIN1 PHF14 ZFR ZZZ3 USF1 SRCAP USF2 PHF3 DDX54 RAVER1	8.65e-08	1294	38	11	30804502
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	WT1 MYCL ACIN1 PHF14 ZFR USF1 SRCAP USF2 ATAD2	1.68e-07	808	38	9	20412781
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	DHX16 FSIP2 PHF14 USF1 SRCAP ATAD2 PHF3 DDX54	2.57e-07	608	38	8	36089195
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 DDX23 ACIN1 ZFR ACTN4 ATAD2 PHF3 DDX54	4.40e-07	653	38	8	22586326
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	DDX23 ACIN1 PHF14 ZFR EIF3A ATAD2 PHF3 CYP51A1 DDX54	9.10e-07	989	38	9	36424410
Pubmed	Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation.	USF1 USF2	1.16e-06	2	38	2	12663044
Pubmed	Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse.	USF1 USF2	1.16e-06	2	38	2	7774954
Pubmed	Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1).	USF1 USF2	1.16e-06	2	38	2	18845576
Pubmed	H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression.	USF1 USF2	1.16e-06	2	38	2	20180799
Pubmed	The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo.	USF1 USF2	1.16e-06	2	38	2	9053857
Pubmed	Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.	USF1 USF2	1.16e-06	2	38	2	8576131
Pubmed	Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease.	USF1 USF2	1.16e-06	2	38	2	16870626
Pubmed	Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose.	USF1 USF2	1.16e-06	2	38	2	9685363
Pubmed	Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription.	USF1 USF2	1.16e-06	2	38	2	15242350
Pubmed	Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells.	USF1 USF2	1.16e-06	2	38	2	8127680
Pubmed	Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.	USF1 USF2	1.16e-06	2	38	2	7852331
Pubmed	Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice.	USF1 USF2	1.16e-06	2	38	2	9520440
Pubmed	[USF as a key regulatory element of gene expression].	USF1 USF2	1.16e-06	2	38	2	16386222
Pubmed	USF inhibits cell proliferation through delay in G2/M phase in FRTL-5 cells.	USF1 USF2	1.16e-06	2	38	2	17379962
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 ACIN1 PHF14 FAM13A ATAD2 PHF3 ANKS1A RAVER1	1.57e-06	774	38	8	15302935
Pubmed	Upstream stimulatory factors are involved in the P1 promoter directed transcription of the A beta H-J-J locus.	USF1 USF2	3.48e-06	3	38	2	19087304
Pubmed	Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1.	USF1 USF2	3.48e-06	3	38	2	12611894
Pubmed	Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2.	USF1 USF2	3.48e-06	3	38	2	18758746
Pubmed	O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2.	USF1 USF2	3.48e-06	3	38	2	16199862
Pubmed	USF-1 and USF-2 trans-repress IL-1beta-induced iNOS transcription in mesangial cells.	USF1 USF2	3.48e-06	3	38	2	12225970
Pubmed	Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter.	USF1 USF2	3.48e-06	3	38	2	21813151
Pubmed	Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.	USF1 USF2	3.48e-06	3	38	2	23653383
Pubmed	Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.	USF1 USF2	3.48e-06	3	38	2	22547438
Pubmed	Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor.	USF1 USF2	3.48e-06	3	38	2	12970752
Pubmed	Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2.	USF1 USF2	3.48e-06	3	38	2	11945176
Pubmed	Upstream stimulating factors regulate the expression of RORγT in human lymphocytes.	USF1 USF2	3.48e-06	3	38	2	22891280
Pubmed	Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes.	USF1 USF2	3.48e-06	3	38	2	15187018
Pubmed	Identification of upstream stimulatory factor binding sites in the human IGFBP3 promoter and potential implication of adjacent single-nucleotide polymorphisms and responsiveness to insulin.	USF1 USF2	3.48e-06	3	38	2	17823260
Pubmed	Archaic structure of the gene encoding transcription factor USF.	USF1 USF2	3.48e-06	3	38	2	7523363
Pubmed	Expressions of heparanase and upstream stimulatory factor in hepatocellular carcinoma.	USF1 USF2	3.48e-06	3	38	2	25149140
Pubmed	Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells.	USF1 USF2	3.48e-06	3	38	2	23749757
Pubmed	In vivo regulation of follicle-stimulating hormone receptor by the transcription factors upstream stimulatory factor 1 and upstream stimulatory factor 2 is cell specific.	USF1 USF2	3.48e-06	3	38	2	18566134
Pubmed	Control of the calcitonin gene-related peptide enhancer by upstream stimulatory factor in trigeminal ganglion neurons.	USF1 USF2	3.48e-06	3	38	2	18167349
Pubmed	Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.	USF1 USF2	3.48e-06	3	38	2	33001025
Pubmed	Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis.	USF1 USF2	3.48e-06	3	38	2	18165439
Pubmed	An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells.	USF1 USF2	3.48e-06	3	38	2	19008453
Pubmed	Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1.	USF1 USF2	3.48e-06	3	38	2	15983197
Pubmed	TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF.	USF1 USF2	3.48e-06	3	38	2	15767439
Pubmed	Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.	MYCL NHLH1 USF1 USF2	4.06e-06	98	38	4	18557763
Pubmed	Differential configurations involving binding of USF transcription factors and Twist1 regulate Alx3 promoter activity in mesenchymal and pancreatic cells.	USF1 USF2	6.96e-06	4	38	2	23181698
Pubmed	Combinatorial gene control involving E2F and E Box family members.	USF1 USF2	6.96e-06	4	38	2	15014447
Pubmed	Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells.	USF1 USF2	6.96e-06	4	38	2	25040025
Pubmed	Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene.	USF1 USF2	6.96e-06	4	38	2	14644095
Pubmed	Cooperative E-box regulation of human GLI1 by TWIST and USF.	USF1 USF2	6.96e-06	4	38	2	11948912
Pubmed	Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiation.	USF1 USF2	6.96e-06	4	38	2	12663664
Pubmed	Analysis of NPHS1, NPHS2, ACTN4, and WT1 in Japanese patients with congenital nephrotic syndrome.	WT1 ACTN4	6.96e-06	4	38	2	15780077
Pubmed	NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.	USF1 USF2	6.96e-06	4	38	2	12791656
Pubmed	Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation.	USF1 USF2	6.96e-06	4	38	2	18817855
Pubmed	Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.	USF1 USF2	6.96e-06	4	38	2	14531897
Pubmed	Interaction of USF1/USF2 and alpha-Pal/Nrf1 to Fmr-1 promoter increases in mouse brain during aging.	USF1 USF2	6.96e-06	4	38	2	18782566
Pubmed	Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver.	USF1 USF2	6.96e-06	4	38	2	9890958
Pubmed	Paralog Studies Augment Gene Discovery: DDX and DHX Genes.	DHX16 DDX54	6.96e-06	4	38	2	31256877
Pubmed	Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2.	USF1 USF2	6.96e-06	4	38	2	15864740
Pubmed	Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.	USF1 USF2	6.96e-06	4	38	2	18762192
Pubmed	USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia.	USF1 USF2	6.96e-06	4	38	2	12917334
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	WT1 MYCL PHF14 ZFR ZZZ3 USF1 USF2	1.03e-05	709	38	7	22988430
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DHX16 DDX23 ACIN1 EFL1 PHF14 ZFR EIF3A PHF3	1.14e-05	1014	38	8	32416067
Pubmed	DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.	USF1 USF2	1.16e-05	5	38	2	22287717
Pubmed	The IGF2 receptor is a USF2-specific target in nontumorigenic mammary epithelial cells but not in breast cancer cells.	USF1 USF2	1.16e-05	5	38	2	12857727
Pubmed	Antagonistic regulation of beta-globin gene expression by helix-loop-helix proteins USF and TFII-I.	USF1 USF2	1.16e-05	5	38	2	16943425
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX16 DDX23 ACIN1 ZFR ACTN4 EIF3A SRCAP ATAD2 DDX54	1.17e-05	1353	38	9	29467282
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX16 DDX23 ACIN1 ZFR ACTN4 EIF3A SRCAP DDX54	1.23e-05	1024	38	8	24711643
Pubmed	Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site.	USF1 USF2	1.74e-05	6	38	2	15466854
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DHX16 DDX23 ACIN1 ZFR EIF3A DDX54 RAVER1	2.38e-05	807	38	7	22681889
Pubmed	Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.	ACTN4 RAVER1	2.43e-05	7	38	2	11724819
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	DHX16 ACIN1 PHF14 ATAD2 DDX54	2.98e-05	332	38	5	25693804
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ACIN1 ZFR ACTN4 EIF3A ATAD2 PHF3 DDX54	3.24e-05	847	38	7	35850772
Pubmed	Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.	USF1 USF2	3.24e-05	8	38	2	15358760
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	DDX23 ACIN1 PHF14 ZFR EIF3A DDX54	4.65e-05	605	38	6	28977666
Pubmed	A role of DNA-PK for the metabolic gene regulation in response to insulin.	USF1 USF2	5.20e-05	10	38	2	19303849
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX16 ACIN1 ZFR ACTN4 EIF3A PHF3 DDX54 RAVER1	5.30e-05	1257	38	8	36526897
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DDX23 ACIN1 SORBS1 EIF3A TCHH USF1 USF2 ANKS1A	6.15e-05	1284	38	8	17353931
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	DDX23 PHF14 ZFR SRCAP DDX54	6.71e-05	394	38	5	27248496
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	DDX23 ACIN1 ZFR GIGYF1 DDX54 RAVER1	7.21e-05	655	38	6	35819319
Pubmed	Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G.	USF1 USF2	7.62e-05	12	38	2	12907752
Pubmed	Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1.	NHLH1 USF1	7.62e-05	12	38	2	9933565
Pubmed	Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.	WT1 ACTN4	9.00e-05	13	38	2	29114040
Pubmed	The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development.	USF1 USF2	9.00e-05	13	38	2	11230134
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	DDX23 ACIN1 ZFR RAVER1	9.71e-05	220	38	4	35785414
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	SRCAP PHF3	1.05e-04	14	38	2	28263302
Pubmed	A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad.	WT1 SORBS1	1.05e-04	14	38	2	15836771
Pubmed	Structural basis and specificity of human otubain 1-mediated deubiquitination.	DDX23 DDX54	1.21e-04	15	38	2	18954305
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DHX16 ACIN1 ZFR ACTN4 EIF3A MYO18B ATAD2 DDX54	1.27e-04	1425	38	8	30948266
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	DDX23 ACIN1 ZFR	1.28e-04	89	38	3	22446626
Pubmed	Human transcription factor protein interaction networks.	NHLH1 ZFR EIF3A GIGYF1 ZZZ3 SRCAP DDX54 RAVER1	1.29e-04	1429	38	8	35140242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	DDX23 ACIN1 PHF14 ZFR ACTN4 EIF3A SRCAP SPEF2	1.38e-04	1442	38	8	35575683
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	DDX23 ZFR EIF3A RAVER1	1.38e-04	241	38	4	23125841
Pubmed	Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.	USF1 USF2	1.56e-04	17	38	2	21653943
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	DDX23 ACIN1 ZFR DDX54	1.61e-04	251	38	4	31076518
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	WT1 DDX23 ZFR ACTN4 USF1 USF2 RAVER1	1.69e-04	1103	38	7	34189442
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	WT1 USF1 USF2	1.76e-04	99	38	3	19730683
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	USF1 USF2	1.76e-04	18	38	2	17846119
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	SRCAP PHF3	1.76e-04	18	38	2	25363768
Pubmed	Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.	MYCL TCHH	1.96e-04	19	38	2	16901790
Interaction	ACTC1 interactions	DHX16 DDX23 ACIN1 ZFR ACTN4 SORBS1 ZZZ3 SRCAP PHF3	4.30e-06	694	38	9	int:ACTC1
Interaction	CFDP1 interactions	NHLH1 PHF14 EIF3A SRCAP	1.46e-05	79	38	4	int:CFDP1
Interaction	TOP1 interactions	DHX16 DDX23 ACIN1 PHF14 ZFR EIF3A SRCAP PHF3	3.79e-05	696	38	8	int:TOP1
Interaction	LZTS2 interactions	DHX16 SORBS1 IGFN1 GIGYF1 USF2 CEP164 RAVER1	4.18e-05	512	38	7	int:LZTS2
Interaction	SIRT7 interactions	DHX16 DDX23 ACIN1 ZFR ACTN4 ATAD2 PHF3 DDX54	6.08e-05	744	38	8	int:SIRT7
Interaction	FHL2 interactions	WT1 ZFR ZZZ3 USF1 USF2 RAVER1	8.99e-05	396	38	6	int:FHL2
Cytoband	19q13	ACTN4 USF2	3.06e-04	31	38	2	19q13
GeneFamily	Basic helix-loop-helix proteins	MYCL NHLH1 USF1 USF2	2.04e-05	110	27	4	420
GeneFamily	DEAD-box helicases	DDX23 DDX54	1.78e-03	42	27	2	499
GeneFamily	PHD finger proteins	PHF14 PHF3	7.93e-03	90	27	2	88
Drug	CP-690334-01 [459212-38-5]; Down 200; 1uM; PC3; HT_HG-U133A	MYCL SORBS1 SRCAP USF2 CEP164 DDX54	9.04e-07	199	38	6	4561_DN
Drug	Prampine [inn:ban]	WT1 ACTN4	1.62e-05	4	38	2	CID003083997
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; PC3; HT_HG-U133A	MYCL SRCAP USF2 FAM13A DYRK3	1.66e-05	193	38	5	4285_DN
Drug	Sulfadoxine [2447-57-6]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MYCL ZFR SRCAP PHF3 DYRK3	1.79e-05	196	38	5	3547_DN
Drug	cde1	USF1 USF2	4.05e-05	6	38	2	CID000092428
Drug	palinavir	EIF3A ATAD2	5.67e-05	7	38	2	CID000072981
Drug	O-Mn	WT1 ACTN4	9.69e-05	9	38	2	CID000448564
Drug	kalinin	USF1 USF2 CYP51A1	1.06e-04	55	38	3	CID000032518
Drug	MBMP	USF1 USF2	1.48e-04	11	38	2	CID000150994
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	ACIN1 ZFR ZZZ3 USF2	2.12e-04	177	38	4	6340_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	WT1 DDX23 ACIN1 ZZZ3	2.21e-04	179	38	4	5822_DN
Drug	Clenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; HL60; HG-U133A	MYCL SRCAP FAM13A DNAH17	2.31e-04	181	38	4	1613_UP
Drug	Resveratrol [501-36-0]; Down 200; 17.6uM; PC3; HT_HG-U133A	WT1 ZFR USF2 CEP164	2.72e-04	189	38	4	5084_DN
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A	BICDL1 SRCAP PHF3 DNAH17	2.78e-04	190	38	4	5579_UP
Drug	Antimycin A [1397-94-0]; Down 200; 7.2uM; PC3; HT_HG-U133A	WT1 ZFR USF2 DDX54	2.95e-04	193	38	4	2098_DN
Drug	Chloroprene	WT1 MYCL PHF14 SORBS1 EIF3A FAM13A EPSTI1 CYP51A1 DYRK3	2.97e-04	1348	38	9	ctd:D002737
Drug	Nilutamide [63612-50-0]; Up 200; 12.6uM; MCF7; HT_HG-U133A	MYCL TCHH USF2 CEP164	3.01e-04	194	38	4	5362_UP
Drug	Albendazole [54965-21-8]; Up 200; 15uM; MCF7; HT_HG-U133A	MYCL BICDL1 SRCAP USF2	3.01e-04	194	38	4	7164_UP
Drug	H-89, Dihydrochloride; Up 200; 0.5uM; PC3; HT_HG-U133A	ZFR USF2 PHF3 DDX54	3.01e-04	194	38	4	6921_UP
Drug	Clobetasol propionate [25122-46-7]; Up 200; 8.6uM; MCF7; HT_HG-U133A	CACNA1A SORBS1 SRCAP USF2	3.01e-04	194	38	4	6835_UP
Drug	Amyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MYCL CACNA1A SRCAP DDX54	3.01e-04	194	38	4	4169_DN
Drug	Methacholine chloride [62-51-1]; Up 200; 20.4uM; MCF7; HT_HG-U133A	TCHH SRCAP CEP164 DDX54	3.07e-04	195	38	4	3452_UP
Drug	Spaglumic acid [4910-46-7]; Down 200; 13.2uM; HL60; HT_HG-U133A	SRCAP USF2 FAM13A DYRK3	3.07e-04	195	38	4	2962_DN
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; HL60; HT_HG-U133A	CACNA1A SRCAP USF2 DDX54	3.13e-04	196	38	4	3069_DN
Drug	Indomethacin [53-86-1]; Up 200; 11.2uM; MCF7; HT_HG-U133A	MYCL SRCAP USF2 DNAH17	3.13e-04	196	38	4	7409_UP
Drug	Trihexyphenidyl-D,L Hydrochloride [58947-95-8]; Down 200; 11.8uM; HL60; HT_HG-U133A	CACNA1A SRCAP USF2 PHF3	3.13e-04	196	38	4	2158_DN
Drug	Glibenclamide [10238-21-8]; Up 200; 8uM; HL60; HG-U133A	CACNA1A USF2 PHF3 DDX54	3.13e-04	196	38	4	1546_UP
Drug	Butamben [94-25-7]; Down 200; 20.6uM; HL60; HT_HG-U133A	CACNA1A USF2 PHF3 DNAH17	3.13e-04	196	38	4	2531_DN
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	MYCL SRCAP USF2 CEP164	3.13e-04	196	38	4	3783_DN
Drug	Scoulerine [6451-73-6]; Up 200; 12.2uM; PC3; HT_HG-U133A	MYCL PHF14 SORBS1 DNAH17	3.13e-04	196	38	4	5111_UP
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; PC3; HT_HG-U133A	SRCAP USF2 PHF3 DDX54	3.13e-04	196	38	4	4656_DN
Drug	Lobeline alpha (-) hydrochoride [134-63-4]; Up 200; 10.6uM; HL60; HG-U133A	CACNA1A USF2 PHF3 DDX54	3.13e-04	196	38	4	1770_UP
Drug	Triamterene [396-01-0]; Down 200; 15.8uM; PC3; HT_HG-U133A	EIF3A SRCAP USF2 PHF3	3.13e-04	196	38	4	1819_DN
Drug	Phenindione [83-12-5]; Up 200; 18uM; HL60; HG-U133A	WT1 CACNA1A BICDL1 SRCAP	3.19e-04	197	38	4	1718_UP
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MYCL DNAH17 DYRK3 DDX54	3.19e-04	197	38	4	5244_DN
Drug	Mafenide hydrochloride [138-37-4]; Up 200; 18uM; MCF7; HT_HG-U133A	BICDL1 SRCAP FAM13A CEP164	3.19e-04	197	38	4	5499_UP
Drug	Isoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SRCAP USF2 CEP164 DYRK3	3.19e-04	197	38	4	1485_DN
Drug	Mianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; HL60; HG-U133A	ZFR SRCAP USF2 PHF3	3.19e-04	197	38	4	1385_UP
Drug	Folinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; MCF7; HT_HG-U133A	BICDL1 PHF3 DYRK3 DDX54	3.19e-04	197	38	4	3442_UP
Drug	Zaprinast [37762-06-4]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MYCL PHF3 CEP164 DYRK3	3.19e-04	197	38	4	3226_DN
Drug	Cefuroxime sodium salt [56238-63-2]; Down 200; 9uM; HL60; HT_HG-U133A	CACNA1A USF2 CEP164 DDX54	3.19e-04	197	38	4	2526_DN
Drug	alpha-estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A_EA	USF2 PHF3 DYRK3 DDX54	3.19e-04	197	38	4	1048_UP
Drug	Allantoin [97-59-6]; Up 200; 25.2uM; HL60; HT_HG-U133A	ZFR ACTN4 SRCAP USF2	3.19e-04	197	38	4	1842_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	MYCL CACNA1A SRCAP DNAH17	3.19e-04	197	38	4	3930_DN
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; PC3; HT_HG-U133A	WT1 SRCAP USF2 FAM13A	3.25e-04	198	38	4	5729_DN
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; MCF7; HT_HG-U133A	MYCL BICDL1 TCHH CEP164	3.25e-04	198	38	4	2294_UP
Drug	Betazole hydrochloride; Down 200; 27uM; PC3; HT_HG-U133A	ZFR SRCAP USF2 PHF3	3.25e-04	198	38	4	1812_DN
Drug	Quinethazone [73-49-4]; Up 200; 13.8uM; PC3; HT_HG-U133A	WT1 SORBS1 FAM13A DNAH17	3.25e-04	198	38	4	4529_UP
Drug	Nitrendipine [39562-70-4]; Down 200; 11uM; HL60; HT_HG-U133A	MYCL ZFR PHF3 CEP164	3.25e-04	198	38	4	3087_DN
Drug	Sulfadimethoxine [122-11-2]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MYCL USF2 PHF3 CEP164	3.25e-04	198	38	4	3441_DN
Drug	Cephapirin sodium salt [24356-60-3]; Down 200; 9uM; HL60; HT_HG-U133A	MYCL SRCAP USF2 PHF3	3.25e-04	198	38	4	2730_DN
Drug	aspirin, USP; Up 200; 100uM; PC3; HT_HG-U133A	MYCL CACNA1A SRCAP USF2	3.25e-04	198	38	4	4428_UP
Drug	Hydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; PC3; HT_HG-U133A	ZFR SRCAP USF2 PHF3	3.25e-04	198	38	4	4282_DN
Drug	Fluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; PC3; HT_HG-U133A	MYCL SRCAP PHF3 CEP164	3.25e-04	198	38	4	3995_UP
Drug	Sulfathiazole [72-14-0]; Up 200; 15.6uM; HL60; HG-U133A	BICDL1 ACTN4 SRCAP USF2	3.25e-04	198	38	4	1963_UP
Drug	Amiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; MCF7; HT_HG-U133A	PHF14 DNAH17 DYRK3 DDX54	3.25e-04	198	38	4	5253_DN
Drug	Etidronic acid, disodium salt [7414-83-7]; Up 200; 16uM; MCF7; HT_HG-U133A	MYCL TCHH PHF3 CEP164	3.25e-04	198	38	4	3325_UP
Drug	Nisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; HL60; HT_HG-U133A	CACNA1A USF2 PHF3 DYRK3	3.25e-04	198	38	4	3117_DN
Drug	Antipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; PC3; HT_HG-U133A	BICDL1 TCHH SRCAP PHF3	3.25e-04	198	38	4	4095_UP
Drug	Antipyrine [60-80-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A	SRCAP PHF3 CEP164 DYRK3	3.31e-04	199	38	4	1489_DN
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Down 200; 9uM; HL60; HT_HG-U133A	MYCL USF2 FAM13A PHF3	3.31e-04	199	38	4	3089_DN
Drug	DAPH; Up 200; 10uM; PC3; HG-U133A	EIF3A SRCAP FAM13A DDX54	3.31e-04	199	38	4	578_UP
Drug	Nitrofurantoin [67-20-9]; Up 200; 16.8uM; HL60; HT_HG-U133A	MYCL SRCAP PHF3 DDX54	3.31e-04	199	38	4	2341_UP
Drug	Chloroquine diphosphate [50-63-5]; Down 200; 7.8uM; HL60; HG-U133A	EFL1 ACTN4 USF2 DDX54	3.31e-04	199	38	4	1719_DN
Drug	Yohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	MYCL SRCAP USF2 DNAH17	3.38e-04	200	38	4	4082_DN
Drug	Azaguanine-8 [134-58-7]; Up 200; 26.2uM; MCF7; HT_HG-U133A	BICDL1 SRCAP USF2 DYRK3	3.38e-04	200	38	4	7444_UP
Drug	Idoxuridine [54-42-2]; Up 200; 11.2uM; HL60; HG-U133A	SRCAP USF2 FAM13A ATAD2	3.38e-04	200	38	4	1980_UP
Disease	Hereditary Nephrotic Syndromes, Autosomal Dominant	WT1 ACTN4	8.82e-05	11	38	2	cv:CN043612
Disease	Familial idiopathic steroid-resistant nephrotic syndrome	WT1 ACTN4	1.25e-04	13	38	2	cv:C4273714
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	WT1 ACTN4	6.87e-04	30	38	2	C1868672
Disease	chronic rhinosinusitis	SPEF2 ANKS1A	8.83e-04	34	38	2	EFO_1000024
Disease	migraine disorder	CACNA1A ACTN4 SORBS1 DYRK3	1.12e-03	357	38	4	MONDO_0005277
Disease	hematocrit	BCLAF3 WT1 SORBS1 FAM13A CEP164 CYP51A1	1.72e-03	1011	38	6	EFO_0004348
Disease	pulse pressure measurement	WT1 ACTN4 SRCAP FAM13A HS6ST3 CEP164 CYP51A1	1.79e-03	1392	38	7	EFO_0005763
Disease	mean platelet volume	BCLAF3 ACTN4 SORBS1 SRCAP FAM13A ANKS1A	1.80e-03	1020	38	6	EFO_0004584
Disease	developmental disorder of mental health (implicated_via_orthology)	GIGYF1 SRCAP	1.83e-03	49	38	2	DOID:0060037 (implicated_via_orthology)
Disease	Small cell carcinoma of lung	MYCL MYO18B	2.22e-03	54	38	2	C0149925

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNRQLEREKRREHSR	ACIN1	1271	Q9UKV3
DKERRHRRRKENQGS	CACNA1A	1021	O00555
RRERARQRHAEKLAA	EFL1	441	Q7Z2Z2
RRLERLDHLAEKFRQ	ACTN4	406	O43707
FLRERNKHLRDERDI	CRACR2A	371	Q9BSW2
RAERFRIQEEHREAK	ANKS1A	896	Q92625
SEDEQHFERRRKRSR	ATAD2	366	Q6PL18
FAERVRQRDKDRTRN	DHX16	181	O60231
EQEKHELRRRFENRE	BICDL1	146	Q6ZP65
KRLEHTERQFRNRRK	RAVER1	46	Q8IY67
REHGERRRKFEFDLR	GIGYF1	241	O75420
AKRRREEARQRDQEF	DDX54	666	Q8TDD1
KRLQENLRREAFREH	EPSTI1	171	Q96J88
RLFLMDREERRQREH	FSIP2	226	Q5CZC0
DREERRQREHTRRKL	FSIP2	231	Q5CZC0
RRRTRHLNDRKFVFE	DDX23	261	Q9BUQ8
RQRRRQSKEQDEVRH	FAM13A	406	O94988
EKHEERVPRERRQRQ	PHF14	841	O94880
EHQRDRQKRREERRL	HS6ST3	426	Q8IZP7
KDLQHLSREERRRRR	NHLH1	56	Q02575
PNDLRHDIERRRKER	BCLAF3	551	A2AJT9
QFELKQHEFRERFRR	DNAH17	1206	Q9UFH2
ERHNRLEERKRQRKE	EIF3A	786	Q14152
FRRRDRAHREIKDIF	CYP51A1	256	Q16850
RKNRKRHREPQEDLR	IGFN1	126	Q86VF2
RNEKRFHRQAAEEIR	DYRK3	241	O43781
RIFREKQHEERRLKD	SPEF2	366	Q9C093
RHHEEQRQKEERARR	SRCAP	171	Q6ZRS2
EDLRRRHREQERKLQ	CEP164	911	Q9UPV0
HNFLERKRRNDLRSR	MYCL	286	P12524
RRRHDDKEKLLADQR	SORBS1	731	Q9BX66
ERRFSRSDQLKRHQR	WT1	361	P19544
QESERHRRRDRSQDK	PHF3	1941	Q92576
RRAQHNEVERRRRDK	USF2	236	Q15853
HRDFDVEKRLRRDLR	MYO18B	1791	Q8IUG5
RFNIHNNRKRRRDSD	ZFR	1041	Q96KR1
QERDRKFREEELRHQ	TCHH	1356	Q07283
EEQQLRQERHRKFRE	TCHH	1451	Q07283
RQERHRKFREEEQLL	TCHH	1456	Q07283
REEQQLHRQERDRKF	TCHH	1631	Q07283
EREQQLRHDRDRKFR	TCHH	1656	Q07283
LRHDRDRKFREEEQL	TCHH	1661	Q07283
NFEREFKNRKRHTRR	ZZZ3	576	Q8IYH5
RDEKRRAQHNEVERR	USF1	196	P22415
RAQHNEVERRRRDKI	USF1	201	P22415