Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	DDX23 CHD2 KIF2A MDN1 ATP11B DYNC2H1 DNAH9 MYO10	1.65e-05	614	38	8	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	DDX23 CHD2 KIF2A MDN1 ATP11B DYNC2H1 DNAH9	1.71e-05	441	38	7	GO:0016887
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF2A DYNC2H1 DNAH9 MYO10	7.32e-05	118	38	4	GO:0003774
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DDX23 CHD2 KIF2A DRG2 MDN1 ATP11B DYNC2H1 DNAH9	8.63e-05	775	38	8	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	DDX23 CHD2 KIF2A DRG2 MDN1 ATP11B DYNC2H1 DNAH9	1.50e-04	839	38	8	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DDX23 CHD2 KIF2A DRG2 MDN1 ATP11B DYNC2H1 DNAH9	1.51e-04	840	38	8	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DDX23 CHD2 KIF2A DRG2 MDN1 ATP11B DYNC2H1 DNAH9	1.51e-04	840	38	8	GO:0016818
GeneOntologyMolecularFunction	microtubule motor activity	KIF2A DYNC2H1 DNAH9	3.19e-04	70	38	3	GO:0003777
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH9	5.29e-04	18	38	2	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DYNC2H1 DNAH9	1.29e-03	28	38	2	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DYNC2H1 DNAH9	2.25e-03	37	38	2	GO:0045505
GeneOntologyMolecularFunction	microtubule binding	NUSAP1 KIF2A NF1 MAP10	2.71e-03	308	38	4	GO:0008017
Domain	ATPase_dyneun-rel_AAA	MDN1 DYNC2H1 DNAH9	2.78e-06	14	38	3	IPR011704
Domain	AAA_5	MDN1 DYNC2H1 DNAH9	2.78e-06	14	38	3	PF07728
Domain	-	GTF2IRD2 GTF2IRD2B	2.41e-05	4	38	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	2.41e-05	4	38	2	IPR004212
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	2.41e-05	4	38	2	PS51139
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	2.41e-05	4	38	2	PF02946
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH9	1.12e-04	8	38	2	IPR013594
Domain	DHC_N1	DYNC2H1 DNAH9	1.12e-04	8	38	2	PF08385
Domain	P-loop_NTPase	DDX23 CHD2 KIF2A DRG2 MDN1 DYNC2H1 DNAH9 MYO10	2.54e-04	848	38	8	IPR027417
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH9	3.61e-04	14	38	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH9	3.61e-04	14	38	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH9	3.61e-04	14	38	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH9	3.61e-04	14	38	2	PF08393
Domain	MT	DYNC2H1 DNAH9	3.61e-04	14	38	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH9	3.61e-04	14	38	2	PF12780
Domain	DHC_fam	DYNC2H1 DNAH9	4.16e-04	15	38	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH9	4.16e-04	15	38	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH9	4.16e-04	15	38	2	PF03028
Domain	AAA+_ATPase	MDN1 DYNC2H1 DNAH9	3.11e-03	144	38	3	IPR003593
Domain	AAA	MDN1 DYNC2H1 DNAH9	3.11e-03	144	38	3	SM00382
Domain	-	DDX23 CHD2 DRG2 MDN1 DYNC2H1 DNAH9	3.69e-03	746	38	6	3.40.50.300
Domain	RNaseH-like_dom	GTF2IRD2 GTF2IRD2B	8.68e-03	69	38	2	IPR012337
Pubmed	NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression.	NUSAP1 KIF2A	1.23e-06	2	39	2	38117947
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2 GTF2IRD2B	1.23e-06	2	39	2	15388857
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2 GTF2IRD2B	3.67e-06	3	39	2	15100712
Pubmed	Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.	GTF2IRD2 GTF2IRD2B	7.34e-06	4	39	2	21328569
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2 GTF2IRD2B	7.34e-06	4	39	2	17823943
Pubmed	Evolution of general transcription factors.	GTF2IRD2 GTF2IRD2B	7.34e-06	4	39	2	23229069
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2 GTF2IRD2B	7.34e-06	4	39	2	22899722
Pubmed	Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma.	LUM PKD2	1.22e-05	5	39	2	19569180
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	NF1 DYNC2H1 DNAH9	2.04e-05	47	39	3	8812413
Pubmed	Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction.	TICAM1 CHUK	4.39e-05	9	39	2	19201871
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NBEA CHD2 NF1 MDN1 FER1L5 DYNC2H1	7.26e-05	638	39	6	31182584
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZNF638 DDX23 CHD2 NF1 MDN1 SDHA	8.24e-05	653	39	6	22586326
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NBEA KIF2A PLCL1 DRG2 NF1 MDN1 KCNJ1	8.66e-05	963	39	7	28671696
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	NXF3 NUSAP1 DDX23 KIF2A MYO10 RPS8	1.44e-04	723	39	6	34133714
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	NBEA DYNC2H1	1.85e-04	18	39	2	27984743
Pubmed	Transcriptional fates of human-specific segmental duplications in brain.	GTF2IRD2 GTF2IRD2B	2.07e-04	19	39	2	30228200
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DDX23 NBEA CHD2 KIF2A MDN1	2.25e-04	497	39	5	36774506
Pubmed	Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.	LUM SDHA	3.33e-04	24	39	2	31241463
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	NBEA KIF2A MDN1	4.13e-04	129	39	3	23022380
Pubmed	Global identification of modular cullin-RING ligase substrates.	NUSAP1 SDHA RPS8	4.62e-04	134	39	3	21963094
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	NBEA DYNC2H1	5.58e-04	31	39	2	25838543
Pubmed	Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.	CHD2 KIF2A	5.58e-04	31	39	2	14684825
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DDX23 CHD2 KIF2A DRG2 MDN1 SDHA RPS8	5.87e-04	1318	39	7	30463901
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZNF638 DDX23 CHD2 KIF2A NF1 MDN1 RPS8	6.85e-04	1353	39	7	29467282
Pubmed	Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.	KCNJ1 PKD2	7.54e-04	36	39	2	33737325
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	NUSAP1 ZNF638 DDX23 KIF2A MDN1 RPS8	7.62e-04	989	39	6	36424410
Pubmed	Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.	KCNJ1 PKD2	7.96e-04	37	39	2	16319116
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZNF638 DDX23 KIF2A NF1 MDN1 RPS8	9.13e-04	1024	39	6	24711643
Pubmed	Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.	DYNC2H1 DNAH9	9.30e-04	40	39	2	32317081
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	ZNF638 DDX23 CHD2 MDN1	9.75e-04	394	39	4	27248496
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	NBEA LUM	9.77e-04	41	39	2	34638806
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	TEPSIN DRG2 MYO10 TICAM1 RPS8 CHUK	9.79e-04	1038	39	6	26673895
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	GTF2IRD2 DDX23 GTF2IRD2B CHD2 MDN1 EFCAB12 CHUK	9.96e-04	1442	39	7	35575683
Cytoband	7q11.23	GTF2IRD2 GTF2IRD2B	3.11e-03	97	39	2	7q11.23
GeneFamily	EF-hand domain containing	RASGRP4 EFCAB12 PKD2	3.71e-03	219	26	3	863
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC9 TTC39A	1.18e-02	115	26	2	769
Disease	QRS duration, response to sulfonylurea	ZNF638 MDN1	3.81e-04	23	37	2	EFO_0005055, EFO_0007922
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	NF1 SDHA	3.81e-04	23	37	2	C1708353
Disease	Malignant neoplasm of breast	NF1 DYNC2H1 DNAH9 KCNJ1 TICAM1 RPS8	2.03e-03	1074	37	6	C0006142
Disease	colon cancer (is_marker_for)	NF1 CHUK	2.50e-03	59	37	2	DOID:219 (is_marker_for)
Disease	response to antipsychotic drug	NBEA DYNC2H1	2.59e-03	60	37	2	GO_0097332

Protein segments in the cluster

Peptide	Gene	Start	Entry
YILAKHRDSLKGPLK	EFCAB12	281	Q6NXP0
KILKDPYLRGELLKH	NXF3	401	Q9H4D5
FKHLAKIGLSYRKGL	MDN1	4131	Q9NU22
LHKRVPKGRLLYGLT	MAP10	486	Q9P2G4
HLLLRKYRVKGLITK	MAGEA11	231	P43364
LKELFGHLSKLLGCK	CHUK	601	O15111
GLGKKRKVSLLFDHL	RASGRP4	186	Q8TDF6
PSRGILKYLKFHLKR	MYO10	1641	Q9HD67
GHGKLKVLKILLYLC	TEPSIN	66	Q96N21
RATKLLKALKGYIKH	NUSAP1	31	Q9BXS6
LKALKGYIKHEARKG	NUSAP1	36	Q9BXS6
ELHAIKERYLGGIKK	DDX23	246	Q9BUQ8
IILRRKGKLHGKFSL	KIF2A	441	O00139
DLKDVIKKGLIHYGR	DYNC2H1	2606	Q8NCM8
YLLKLLRKGLEKKGA	CHD2	1316	O14647
KILGPLSYSKIKHLR	LUM	296	P51884
LGGGLVLLLHHKKYS	GLMP	386	Q8WWB7
GLLKTALDFHKLGKV	DNAH9	451	Q9NYC9
LHELKKGLRKYLLGS	GTF2IRD2	486	Q86UP8
LHELKKGLRKYLLGS	GTF2IRD2B	486	Q6EKJ0
LRPDLGKLKKILYFH	GTDC1	76	Q4AE62
HYALPLGRKKGAKLT	RPS8	116	P62241
SYLLKEKLNILGKLG	NIPA1	111	Q7RTP0
YGVILHSLKKLSQKG	OR4A4P	216	Q8NGN8
LGLGLRHKAYERKLG	CWH43	406	Q9H720
CGKISKLYGDLKHLK	SDHA	536	P31040
HGLGPKKERLALYLL	FER1L5	1651	A0AVI2
LKVLGYFLKHLGHKR	NBEA	766	Q8NFP9
KATEYHLGLLKAKLA	DRG2	21	P55039
GAGLKVLFKKTHRIL	BRINP2	376	Q9C0B6
LLLLYKRHKGRKLTV	CHSY3	541	Q70JA7
KTLGKLERYKLLHIL	ATP11B	556	Q9Y2G3
LHNLGAKEGLKGRKL	PLCL1	1006	Q15111
GAAGQDKLLYLKHKL	TICAM1	16	Q8IUC6
KYHERLLTGLKGSKR	NF1	1691	P21359
SDLIRKGYHKALVKL	PKD2	701	Q13563
LVKLLKGLCLKYLGR	TTC39A	506	Q5SRH9
GLKDILILSSHKKAY	ZNF638	931	Q14966
AIGKYHRALLELKGL	TTC9	76	Q92623
LRKSLLIGSHIYGKL	KCNJ1	216	P48048