Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2B6 CYP2C8 CYP2C18	1.70e-05	24	42	3	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2B6 CYP2C8 CYP2C18	2.44e-05	27	42	3	GO:0008391
GeneOntologyMolecularFunction	aromatase activity	CYP2B6 CYP2C8 CYP2C18	5.40e-05	35	42	3	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2B6 CYP2C8 CYP2C18	1.49e-04	49	42	3	GO:0016712
GeneOntologyMolecularFunction	heme binding	NOX4 CYP2B6 CYP2C8 CYP2C18	3.03e-04	154	42	4	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	NOX4 CYP2B6 CYP2C8 CYP2C18	3.85e-04	164	42	4	GO:0046906
GeneOntologyMolecularFunction	retinoic acid 4-hydroxylase activity	CYP2C8 CYP2C18	3.87e-04	14	42	2	GO:0008401
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2B6 CYP2C8 CYP2C18	1.01e-05	22	40	3	GO:0019373
GeneOntologyBiologicalProcess	xenobiotic catabolic process	CYP2B6 CYP2C8 UGT2B11	5.02e-05	37	40	3	GO:0042178
Domain	Cyt_P450_E_grp-I	CYP2B6 CYP2C8 CYP2C18	1.31e-04	45	41	3	IPR002401
Domain	Cyt_P450_CS	CYP2B6 CYP2C8 CYP2C18	2.13e-04	53	41	3	IPR017972
Domain	CYTOCHROME_P450	CYP2B6 CYP2C8 CYP2C18	2.65e-04	57	41	3	PS00086
Domain	-	CYP2B6 CYP2C8 CYP2C18	2.79e-04	58	41	3	1.10.630.10
Domain	p450	CYP2B6 CYP2C8 CYP2C18	2.79e-04	58	41	3	PF00067
Domain	SAND_dom-like	SKOR1 SP110	3.06e-04	12	41	2	IPR010919
Domain	-	SKOR1 SP110	3.06e-04	12	41	2	3.10.390.10
Domain	Cyt_P450	CYP2B6 CYP2C8 CYP2C18	3.08e-04	60	41	3	IPR001128
Domain	BROMODOMAIN_1	SP110 BRD9	2.98e-03	37	41	2	PS00633
Domain	BROMODOMAIN_2	SP110 BRD9	3.65e-03	41	41	2	PS50014
Domain	BROMO	SP110 BRD9	3.83e-03	42	41	2	SM00297
Domain	Bromodomain	SP110 BRD9	3.83e-03	42	41	2	IPR001487
Domain	-	SP110 BRD9	3.83e-03	42	41	2	1.20.920.10
Pathway	KEGG_RETINOL_METABOLISM	CYP2B6 CYP2C8 CYP2C18 UGT2B11	5.36e-06	64	26	4	M9488
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	CYP2B6 CYP2C8 CYP2C18 UGT2B11	7.67e-06	70	26	4	M16794
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	CYP2B6 CYP2C8 CYP2C18 UGT2B11	8.59e-06	72	26	4	M9257
Pathway	REACTOME_XENOBIOTICS	CYP2B6 CYP2C8 CYP2C18	9.63e-06	23	26	3	M5372
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY	CYP2C8 CYP2C18	1.17e-04	9	26	2	M39819
Pathway	KEGG_ARACHIDONIC_ACID_METABOLISM	CYP2B6 CYP2C8 CYP2C18	1.61e-04	58	26	3	M5410
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2B6 CYP2C8	1.78e-04	11	26	2	M27130
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP2B6 CYP2C8 CYP2C18	1.96e-04	62	26	3	M39653
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2B6 CYP2C8	2.13e-04	12	26	2	MM14847
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2B6 CYP2C8 CYP2C18	2.15e-04	64	26	3	M5650
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	CYP2B6 CYP2C8 CYP2C18 UGT2B11	3.29e-04	183	26	4	M39588
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	ABCD4 GABRQ NOX4 PLCG1 SIRT3	4.88e-04	367	26	5	M48346
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	CYP2B6 CYP2C8 CYP2C18 UGT2B11	6.59e-04	220	26	4	M10320
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2B6 CYP2C8 CYP2C18	8.96e-04	104	26	3	M738
Pathway	REACTOME_XENOBIOTICS	CYP2B6 CYP2C8	9.56e-04	25	26	2	MM14846
Pathway	WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY	NOX4 COL1A1	1.20e-03	28	26	2	M42541
Pathway	KEGG_LINOLEIC_ACID_METABOLISM	CYP2C8 CYP2C18	1.29e-03	29	26	2	M2920
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	LAMC1 COL1A1	1.38e-03	30	26	2	M27772
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	LAMC1 COL1A1	1.38e-03	30	26	2	M39641
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	LAMC1 COL1A1	1.38e-03	30	26	2	MM15812
Pubmed	Gene expression in distinct regions of the heart.	CYP2B6 CYP2C8 CYP2C18	6.54e-09	4	42	3	10768437
Pubmed	CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.	CYP2B6 CYP2C8 CYP2C18	3.58e-07	12	42	3	15319333
Pubmed	Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.	CYP2B6 CYP2C8 CYP2C18	5.91e-07	14	42	3	19290787
Pubmed	A novel type of myosin encoded by the mouse deafness gene shaker-2.	LLGL1 MYO15A	1.42e-06	2	42	2	9703981
Pubmed	Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs.	CYP2C8 CYP2C18	1.42e-06	2	42	2	10487415
Pubmed	{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.	NOX4 SIRT3	1.42e-06	2	42	2	25961022
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2B6 CYP2C8 CYP2C18	1.84e-06	20	42	3	9890157
Pubmed	The human CYP2C locus: a prototype for intergenic and exon repetition splicing events.	CYP2C8 CYP2C18	4.27e-06	3	42	2	10704292
Pubmed	Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.	NOX4 CYP2C8 CYP2C18	4.69e-06	27	42	3	28167773
Pubmed	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	CYP2B6 CYP2C8 CYP2C18	6.50e-06	30	42	3	20529763
Pubmed	Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.	CYP2C8 CYP2C18	8.53e-06	4	42	2	2009263
Pubmed	Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.	CYP2C8 CYP2C18	8.53e-06	4	42	2	21798861
Pubmed	Biochemistry and molecular biology of the human CYP2C subfamily.	CYP2C8 CYP2C18	8.53e-06	4	42	2	7704034
Pubmed	Genetic and physical delineation of the region of the mouse deafness mutation shaker-2.	LLGL1 MYO15A	8.53e-06	4	42	2	9168970
Pubmed	Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.	CYP2C8 CYP2C18	8.53e-06	4	42	2	23755828
Pubmed	Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.	CYP2C8 CYP2C18	8.53e-06	4	42	2	19706858
Pubmed	Direct sequencing and comprehensive screening of genetic polymorphisms on CYP2 family genes (CYP2A6, CYP2B6, CYP2C8, and CYP2E1) in five ethnic populations.	CYP2B6 CYP2C8	8.53e-06	4	42	2	24988984
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	LAMC1 BTBD7 COL1A1	1.24e-05	37	42	3	34323105
Pubmed	Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.	CYP2C8 CYP2C18	1.42e-05	5	42	2	9797707
Pubmed	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.	CYP2C8 CYP2C18	1.42e-05	5	42	2	11093772
Pubmed	Nidogen-2: a new basement membrane protein with diverse binding properties.	LAMC1 COL1A1	2.13e-05	6	42	2	9733643
Pubmed	HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1.	NOX4 CYP2B6	2.98e-05	7	42	2	24113184
Pubmed	The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression.	ABCD4 PEX2	2.98e-05	7	42	2	10504404
Pubmed	Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.	CYP2B6 CYP2C8	6.37e-05	10	42	2	19651758
Pubmed	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.	CYP2B6 CYP2C8	6.37e-05	10	42	2	12865317
Pubmed	Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.	CYP2B6 CYP2C8	7.78e-05	11	42	2	16538176
Pubmed	Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.	CYP2B6 CYP2C8	7.78e-05	11	42	2	15039299
Pubmed	Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.	FCHSD2 COL1A1	7.78e-05	11	42	2	15101818
Pubmed	Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.	CYP2B6 CYP2C8	7.78e-05	11	42	2	15469410
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP2B6 CYP2C8 CYP2C18	8.47e-05	70	42	3	15128046
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCD4 CYP2B6 CYP2C8 UGT2B11	8.72e-05	193	42	4	19343046
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	LLGL1 MYO15A	1.10e-04	13	42	2	10049592
Pubmed	The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.	LAMC1 COL1A1	1.10e-04	13	42	2	36350252
Pubmed	Toward personalized medicine in renal transplantation.	CYP2B6 CYP2C8	1.28e-04	14	42	2	20970553
Pubmed	SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.	HSDL2 SIRT3	1.48e-04	15	42	2	31108370
Pubmed	Association of warfarin dose with genes involved in its action and metabolism.	CYP2C8 CYP2C18	1.69e-04	16	42	2	17048007
Pubmed	Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip.	CYP2B6 CYP2C8	1.69e-04	16	42	2	20136364
Pubmed	PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.	PLCG1 LLGL1 ANK3	2.03e-04	94	42	3	32062451
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	ABCD4 LAMC1 TMEM161A EPS15L1 LLGL1 YBEY	2.13e-04	719	42	6	35337019
Pubmed	Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.	LAMC1 COL1A1	2.15e-04	18	42	2	11311202
Pubmed	Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs.	LAMC1 COL1A1	2.15e-04	18	42	2	12571105
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMC1 COL1A1	2.15e-04	18	42	2	39040056
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	FARSA CYP2C8 CYP2C18	3.32e-04	111	42	3	21163940
Pubmed	Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse.	LLGL1 MYO15A	3.86e-04	24	42	2	11997338
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	PEX2 HSDL2	4.54e-04	26	42	2	30378028
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMC1 COL1A1	4.54e-04	26	42	2	34189436
Pubmed	Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.	CYP2B6 CYP2C8	4.90e-04	27	42	2	20173083
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	PEX2 HSDL2	5.28e-04	28	42	2	22002062
Pubmed	Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.	VWDE COL1A1	5.28e-04	28	42	2	23006423
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	LAMC1 ITIH2 COL1A1	5.88e-04	135	42	3	28675934
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	LAMC1 ITIH2 COL1A1	8.45e-04	153	42	3	25037231
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMC1 ITIH2 COL1A1	1.09e-03	167	42	3	22159717
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	PRR22 TMEM161A FARSA EPS15L1 REXO1	7.78e-04	797	42	5	chr19p13
Cytoband	2q37.1	DIS3L2 SP110	1.74e-03	67	42	2	2q37.1
Cytoband	19p13.11	TMEM161A EPS15L1	2.06e-03	73	42	2	19p13.11
GeneFamily	Cytochrome P450 family 2	CYP2B6 CYP2C8 CYP2C18	2.88e-05	35	31	3	1001
Computational	Cytochrome P450.	CYP2B6 CYP2C8 CYP2C18	3.50e-06	14	24	3	MODULE_106
Computational	Genes in the cancer module 135.	CYP2B6 CYP2C8 CYP2C18	2.18e-05	25	24	3	MODULE_135
Drug	4',5-dihydroxydiclofenac	CYP2B6 CYP2C8 CYP2C18	1.16e-07	6	42	3	CID003052567
Drug	3'-hydroxydiclofenac	CYP2B6 CYP2C8 CYP2C18	1.16e-07	6	42	3	CID000112230
Drug	11-H-14,15-EETA	GABRQ CYP2B6 CYP2C8 CYP2C18	2.65e-07	30	42	4	CID011954058
Drug	15-H-11,12-EETA	GABRQ CYP2B6 CYP2C8 CYP2C18	5.64e-07	36	42	4	CID011954042
Drug	11,14,15-THET	GABRQ CYP2B6 CYP2C8 CYP2C18	7.85e-07	39	42	4	CID006439531
Drug	11,12,15-trihydroxyeicosatrienoic acid	GABRQ CYP2B6 CYP2C8 CYP2C18	1.06e-06	42	42	4	CID006439610
Drug	5-hydroxydiclofenac	CYP2B6 CYP2C8 CYP2C18	1.27e-06	12	42	3	CID003052566
Drug	sulindac; Up 200; 50uM; MCF7; HG-U133A	NDNF TMEM161A FCHSD2 PLCG1 LLGL1 SIRT3	1.62e-06	198	42	6	307_UP
Drug	2'-(glutathion-S-yl)-deschlorodiclofenac	CYP2B6 CYP2C8 CYP2C18	2.62e-06	15	42	3	ctd:C586542
Drug	triazolam	GABRQ CYP2B6 CYP2C8 CYP2C18	2.96e-06	54	42	4	CID000005556
Drug	hexobarbital	GABRQ CYP2B6 CYP2C8 CYP2C18 UGT2B11	3.60e-06	127	42	5	CID000003608
Drug	Azamulinum	CYP2B6 CYP2C8 CYP2C18	4.67e-06	18	42	3	CID003086060
Drug	D 703	CYP2B6 CYP2C8 CYP2C18	4.67e-06	18	42	3	CID000054088
Drug	D 617	CYP2B6 CYP2C8 CYP2C18	5.54e-06	19	42	3	CID000093168
Drug	hydroxytolbutamide	CYP2B6 CYP2C8 CYP2C18	5.54e-06	19	42	3	CID000003656
Drug	3C etc	CYP2B6 CYP2C8 CYP2C18	6.51e-06	20	42	3	CID000164045
Drug	4-bromophenol	NT5C1A CYP2B6 CYP2C8 CYP2C18	8.39e-06	70	42	4	CID000007808
Drug	etizolam	GABRQ CYP2B6 CYP2C18	8.77e-06	22	42	3	CID000003307
Drug	1,2-dibromoethane	GABRQ CYP2B6 CYP2C8 CYP2C18	8.88e-06	71	42	4	CID000007839
Drug	2,2,2-trichloroethanol	CYP2B6 CYP2C8 CYP2C18 UGT2B11	9.93e-06	73	42	4	CID000008259
Drug	3-hydroxymethylantipyrine	CYP2B6 CYP2C8 CYP2C18	1.01e-05	23	42	3	CID000123963
Drug	C20H32O4	GABRQ CYP2B6 CYP2C8 CYP2C18	1.29e-05	78	42	4	CID000001440
Drug	ebastine	GABRQ CYP2B6 CYP2C8	1.31e-05	25	42	3	CID000003191
Drug	1,4-naphthoquinone	CYP2B6 CYP2C8 CYP2C18	1.47e-05	26	42	3	ctd:C035342
Drug	C14845	CYP2B6 CYP2C8 CYP2C18	1.66e-05	27	42	3	CID011954064
Drug	BP-9,10-oxide	CYP2B6 CYP2C8 CYP2C18	1.66e-05	27	42	3	CID000037456
Drug	Brn 4136738	CYP2B6 CYP2C8 CYP2C18	1.66e-05	27	42	3	CID000050331
Drug	9-OH-BaP-4,5-oxide	CYP2B6 CYP2C8 CYP2C18	1.85e-05	28	42	3	CID000115064
Drug	norverapamil	CYP2B6 CYP2C8 CYP2C18	1.85e-05	28	42	3	CID000104972
Drug	7-ethoxycoumarin	CYP2B6 CYP2C8 CYP2C18 UGT2B11	1.90e-05	86	42	4	CID000035703
Drug	clotiazepam	GABRQ CYP2B6 CYP2C18	2.06e-05	29	42	3	CID000002811
Drug	4-hydroxyantipyrine	CYP2B6 CYP2C8 CYP2C18	2.06e-05	29	42	3	CID000098889
Drug	tofisopam	GABRQ CYP2B6 CYP2C18	2.06e-05	29	42	3	CID000005502
Drug	19-hydroxytestosterone	CYP2B6 CYP2C8 CYP2C18	2.29e-05	30	42	3	CID000150968
Drug	Levonordefrin [829-74-3]; Up 200; 21.8uM; PC3; HT_HG-U133A	ABCD4 CYP2B6 RAMP2 LLGL1 SIRT3	2.36e-05	187	42	5	5854_UP
Drug	2-naphthol	CYP2B6 CYP2C8 CYP2C18 UGT2B11	2.59e-05	93	42	4	CID000008663
Drug	C75; Down 200; 10uM; MCF7; HT_HG-U133A	CYP2B6 MYO15A BTBD7 SIRT3 COL1A1	2.74e-05	193	42	5	6394_DN
Drug	BP-7,8-oxide	CYP2B6 CYP2C8 CYP2C18	2.79e-05	32	42	3	CID000037455
Drug	walrycin A	CYP2B6 CYP2C8 CYP2C18	2.79e-05	32	42	3	ctd:C574123
Drug	ethoxyresorufin	CYP2B6 CYP2C8 CYP2C18 UGT2B11	2.82e-05	95	42	4	CID000003294
Drug	Nefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A	PLCG1 SP110 BTBD7 SIRT3 COL1A1	2.88e-05	195	42	5	2317_DN
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	PLCG1 ANK3 SP110 BTBD7 COL1A1	2.95e-05	196	42	5	1684_DN
Drug	Diprophylline [479-18-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A	RAMP2 LLGL1 BTBD7 SIRT3 COL1A1	3.02e-05	197	42	5	5482_UP
Drug	Minaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	FARSA PLCG1 SP110 BTBD7 SIRT3	3.02e-05	197	42	5	4814_DN
Drug	1-naphthol	CYP2B6 CYP2C8 UGT2B11	3.06e-05	33	42	3	ctd:C029350
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A	PLCG1 ANK3 SP110 BTBD7 SIRT3	3.17e-05	199	42	5	7338_DN
Drug	PCB 77	CYP2B6 CYP2C8 CYP2C18 COL1A1	3.19e-05	98	42	4	CID000036187
Drug	1-hydroxy-2,3,5-trimethoxyxanthone	CYP2B6 CYP2C8	3.31e-05	5	42	2	ctd:C478004
Drug	DEDTC	CYP2B6 CYP2C8 CYP2C18	3.36e-05	34	42	3	CID000032064
Drug	12(13)-EpOME	CYP2B6 CYP2C8 CYP2C18	3.36e-05	34	42	3	CID000001416
Drug	TCEO	CYP2B6 CYP2C8 CYP2C18	3.36e-05	34	42	3	CID000028167
Drug	AC1O5XSP	CYP2B6 CYP2C8 CYP2C18	3.36e-05	34	42	3	CID006442739
Drug	AC1L1CJI	CYP2B6 CYP2C8 CYP2C18	3.67e-05	35	42	3	CID000001929
Drug	AC1L3NGJ	CYP2B6 CYP2C8 CYP2C18	3.99e-05	36	42	3	CID000092121
Drug	Aroclor 1254	CYP2B6 LIMS1 CYP2C8 CYP2C18 UGT2B11	4.39e-05	213	42	5	CID000040470
Drug	mono-OH	CYP2B6 CYP2C18	4.96e-05	6	42	2	CID000183679
Drug	furafylline	CYP2B6 CYP2C8 CYP2C18	5.93e-05	41	42	3	CID000003433
Drug	AC1Q7AUJ	CYP2B6 CYP2C8 CYP2C18 UGT2B11	6.38e-05	117	42	4	CID000003303
Drug	alpha-naphthoflavone	CYP2B6 CYP2C8 CYP2C18 UGT2B11	6.59e-05	118	42	4	CID000011790
Drug	benzphetamine	CYP2B6 CYP2C8 CYP2C18 UGT2B11	6.81e-05	119	42	4	CID000002341
Drug	5-fluorotryptamine	CYP2B6 CYP2C8	6.94e-05	7	42	2	ctd:C034536
Drug	trichloroacetyl chloride	CYP2B6 CYP2C8	6.94e-05	7	42	2	CID000006420
Drug	5-hydroxydiclofenac	CYP2B6 CYP2C18	6.94e-05	7	42	2	ctd:C117715
Drug	sulfaphenazole	CYP2B6 CYP2C8 CYP2C18	7.33e-05	44	42	3	CID000005335
Drug	polybrominated biphenyl	CYP2B6 CYP2C8 CYP2C18	7.33e-05	44	42	3	CID000042948
Drug	3 -hydroxypregn-5-en-20-one	GABRQ CYP2B6 CYP2C8 CYP2C18 UGT2B11	7.43e-05	238	42	5	CID000001027
Drug	naphthalene-1,2-dihydrodiol	CYP2B6 CYP2C8 CYP2C18	7.85e-05	45	42	3	CID000000362
Drug	C14802	CYP2B6 CYP2C8 CYP2C18	8.94e-05	47	42	3	CID011954053
Drug	3-hydroxycarbamazepine	CYP2B6 CYP2C8	9.24e-05	8	42	2	CID000135290
Drug	5-bromotryptamine	CYP2B6 CYP2C8	9.24e-05	8	42	2	ctd:C040997
Drug	clobazam	CYP2B6 CYP2C18	9.24e-05	8	42	2	ctd:C012255
Drug	chloral hydrate	GABRQ CYP2B6 CYP2C8 CYP2C18	9.32e-05	129	42	4	CID000002707
Drug	C14800	CYP2B6 CYP2C8 CYP2C18	9.53e-05	48	42	3	CID011954051
Drug	2cgu	CYP2B6 CYP2C8 COL1A1	9.53e-05	48	42	3	CID003506204
Drug	nitro-L	CYP2B6 CYP2C8 CYP2C18	9.53e-05	48	42	3	CID000006849
Drug	19-HETE	CYP2B6 CYP2C8 CYP2C18	1.01e-04	49	42	3	CID006439528
Drug	bromobenzene-3,4-oxide	CYP2B6 CYP2C8 CYP2C18	1.01e-04	49	42	3	CID000108121
Drug	bromobenzene-2,3-oxide	CYP2B6 CYP2C8 CYP2C18	1.08e-04	50	42	3	CID003036760
Drug	6-hydroxymelatonin	CYP2B6 CYP2C8 CYP2C18	1.08e-04	50	42	3	CID000001864
Drug	1,1-dichloroethylene epoxide	CYP2B6 CYP2C8 CYP2C18	1.08e-04	50	42	3	CID000119521
Drug	naphthalene epoxide	CYP2B6 CYP2C8 CYP2C18	1.14e-04	51	42	3	CID000108063
Drug	Ro 21-5104	CYP2B6 CYP2C8	1.19e-04	9	42	2	ctd:C057006
Drug	4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide	CYP2B6 CYP2C18	1.19e-04	9	42	2	ctd:C545880
Drug	trifluoroacetyl chloride	CYP2B6 CYP2C8	1.19e-04	9	42	2	CID000061106
Drug	des-CIC	CYP2B6 CYP2C8	1.19e-04	9	42	2	CID006918281
Drug	5-chlorotryptamine	CYP2B6 CYP2C8	1.19e-04	9	42	2	ctd:C529169
Drug	5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid	CYP2B6 CYP2C8	1.19e-04	9	42	2	ctd:C000588958
Drug	Tryptamines	CYP2B6 CYP2C8	1.19e-04	9	42	2	ctd:D014363
Drug	N-desmethylclobazam	CYP2B6 CYP2C18	1.19e-04	9	42	2	CID000089657
Drug	usnic acid	CYP2B6 CYP2C18	1.19e-04	9	42	2	CID000005646
Drug	9-hydroxybenzo(a)pyrene	CYP2B6 CYP2C8 CYP2C18	1.28e-04	53	42	3	CID000028598
Drug	aniline	CYP2B6 CYP2C8 CYP2C18 UGT2B11	1.35e-04	142	42	4	CID000006115
Drug	dichloroacetaldehyde	CYP2B6 CYP2C8 CYP2C18	1.36e-04	54	42	3	CID000006576
Drug	chloroacetyl chloride	CYP2B6 CYP2C8 CYP2C18	1.43e-04	55	42	3	CID000006577
Drug	2 E1	CYP2B6 CYP2C8 CYP2C18 UGT2B11	1.46e-04	145	42	4	CID006102788
Drug	2-hydroxycarbamazepine	CYP2B6 CYP2C8	1.48e-04	10	42	2	CID000129274
Drug	4-cresol sulfate	NOX4 COL1A1	1.48e-04	10	42	2	ctd:C408690
Drug	norketobemidone	CYP2B6 CYP2C8	1.48e-04	10	42	2	CID000161154
Drug	1,2-dihydroxynaphthalene	CYP2B6 CYP2C8 CYP2C18	1.59e-04	57	42	3	CID000011318
Drug	bromoacetaldehyde	CYP2B6 CYP2C8 CYP2C18	1.68e-04	58	42	3	CID000105131
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	CYP2C18 UGT2B11	7.08e-05	9	42	2	EFO_0600040
Disease	gliosarcoma	CYP2B6 CYP2C18	2.34e-04	16	42	2	C0206726
Disease	X-24947 measurement	CYP2C8 UGT2B11	4.49e-04	22	42	2	EFO_0800910
Disease	Sezary Syndrome	PLCG1 BRD9	6.79e-04	27	42	2	C0036920
Disease	tuberculosis (is_implicated_in)	CYP2B6 SP110	7.30e-04	28	42	2	DOID:399 (is_implicated_in)
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	SIRT3 COL1A1	1.21e-03	36	42	2	DOID:0080208 (implicated_via_orthology)
Disease	response to serotonin-norephinephrine reuptake inhibitor	FCHSD2 ANK3	1.21e-03	36	42	2	EFO_0006325
Disease	testosterone measurement	PEX2 CYP2C8 PLCG1 MYO15A ANK3 UGT2B11 REXO1	1.98e-03	1275	42	7	EFO_0004908
Disease	Kidney Failure, Chronic	NOX4 CYP2B6	2.14e-03	48	42	2	C0022661
Disease	depressive disorder (biomarker_via_orthology)	CYP2B6 CYP2C18	2.51e-03	52	42	2	DOID:1596 (biomarker_via_orthology)
Disease	health literacy measurement	NOX4 FCHSD2	2.60e-03	53	42	2	EFO_0010104
Disease	ecosanoids measurement	CYP2C8 CYP2C18	2.80e-03	55	42	2	EFO_0020044

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPFHEHLKAGEFPQP	YBEY	66	P58557
HLKAGEFPQPDFPDD	YBEY	71	P58557
NGAPFPAAFPKDNIH	ZNF280B	231	Q86YH2
PPLDFKHLLAFHFNG	ZNF385C	26	Q66K41
PFKGDPFQNDPFAEQ	EPS15L1	636	Q9UBC2
LHDPHYFEKPDAFNP	CYP2B6	396	P20813
HENEPFSPGPAFPFV	NT5C1A	86	Q9BXI3
QLQRKDPHGFFAFPV	BRD9	151	Q9H8M2
HDDKEFPNPNIFDPG	CYP2C8	396	P10632
FPNPNIFDPGHFLDK	CYP2C8	401	P10632
FGPHGVLFLPQKPFF	ABCD4	451	O14678
IGFDPEPQEKFHPVF	C7orf31	311	Q8N865
NPKKFHEAFIPSPDG	DIS3L2	76	Q8IYB7
AQDLPHFPGPFSINE	CDHR4	171	A6H8M9
PGKHEFPFRFQLPSE	ARRDC4	111	Q8NCT1
EHFAELFDLGFPNPL	RAMP2	101	O60895
HGFPNQPSALAFDPE	LLGL1	31	Q15334
VHFFAPDNLDPIPKN	ITIH2	296	P19823
EPLGFLPFEDEAPFH	MYO15A	201	Q9UKN7
AEGNYPSPIPKFHFE	GABRQ	21	Q9UN88
PAFVKNHGLLPQPEF	MGAT5B	506	Q3V5L5
FHGFKPGLLARFEPE	PEX2	41	P28328
PKPGLDFSPFDFAHF	NDNF	241	Q8TB73
AIKPGHPLQPDFFLD	HSDL2	261	Q6YN16
FPQPQHFDSFGLRLP	POGK	141	Q9P215
HFHEPFPEGFSKPAE	NOX4	246	Q9NPH5
SEPNPFPFHEGKMFE	ANK3	3596	Q12955
LQNPHKFFPDERFGD	BTBD7	706	Q9P203
DGFFGNPLAPNPADK	LAMC1	866	P11047
FPNPEMFDPGHFLDK	CYP2C18	401	P33260
AVFHKPQPFQFQPCD	FCHSD2	291	O94868
PSGNPHAKPTDFDFL	SGK3	151	Q96BR1
QDQLKENGYPFPHPE	REXO1	936	Q8N1G1
FLGEHKPPKLPENFA	SKOR1	166	P84550
PFKPYNFLAHGVLPD	FARSA	206	Q9Y285
KPIARDFLHQPPFGE	TMEM161A	286	Q9NX61
PEAIFELPFFFHNPK	SIRT3	176	Q9NTG7
PLIFKNDPYHPDHFN	LIMS1	146	P48059
AIHKPFPFFEGLLDN	SP110	26	Q9HB58
FDFSFLPQPPQEKAH	COL1A1	1196	P02452
FNFKALDEEQPPHPG	PRR22	356	Q8IZ63
KRQNFHEFPPLFAFP	VWDE	751	Q8N2E2
PAKPFHFQISNPEFA	PLCG1	1141	P19174
FPHPFLPNVDFVGGF	UGT2B11	266	O75310
LLNFSFKDNFPFDPP	UBE2Q1	316	Q7Z7E8