Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	PTW/PP1 phosphatase complex	PPP1CA PPP1CC	3.89e-05	7	29	2	GO:0072357
GeneOntologyCellularComponent	protein phosphatase type 1 complex	PPP1CA PPP1CC	3.13e-04	19	29	2	GO:0000164
Domain	STPPase_N	PPP1CA PPP1CC	7.99e-06	3	31	2	PF16891
Domain	STPPase_N	PPP1CA PPP1CC	7.99e-06	3	31	2	IPR031675
Domain	Ser/Thr-sp_prot-phosphatase	PPP1CA PPP1CC	2.06e-04	13	31	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP1CA PPP1CC	2.06e-04	13	31	2	PS00125
Domain	PP2Ac	PPP1CA PPP1CC	2.06e-04	13	31	2	SM00156
Domain	Calcineurin-like_PHP_ApaH	PPP1CA PPP1CC	9.81e-04	28	31	2	IPR004843
Domain	Metallophos	PPP1CA PPP1CC	9.81e-04	28	31	2	PF00149
Domain	Metallo-depent_PP-like	PPP1CA PPP1CC	1.13e-03	30	31	2	IPR029052
Domain	-	PPP1CA PPP1CC	1.13e-03	30	31	2	3.60.21.10
Domain	ZnF_C3H1	MKRN4P MKRN1	2.87e-03	48	31	2	SM00356
Domain	zf-CCCH	MKRN4P MKRN1	2.99e-03	49	31	2	PF00642
Domain	Znf_CCCH	MKRN4P MKRN1	4.16e-03	58	31	2	IPR000571
Domain	LIM	LHX2 ISL1	5.84e-03	69	31	2	PF00412
Domain	-	LHX2 ISL1	6.00e-03	70	31	2	2.10.110.10
Domain	LIM_DOMAIN_2	LHX2 ISL1	6.17e-03	71	31	2	PS50023
Domain	Znf_LIM	LHX2 ISL1	6.17e-03	71	31	2	IPR001781
Domain	LIM_DOMAIN_1	LHX2 ISL1	6.17e-03	71	31	2	PS00478
Domain	LIM	LHX2 ISL1	6.17e-03	71	31	2	SM00132
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	PPP1CA PPP1CC	7.09e-05	8	23	2	M47933
Pathway	KEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX	PPP1CA PPP1CC	1.66e-04	12	23	2	M47887
Pathway	KEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE	PPP1CA PPP1CC	1.66e-04	12	23	2	M47891
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	MKRN4P MKRN1	1.66e-04	12	23	2	MM14777
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION	PPP1CA PPP1CC	3.01e-04	16	23	2	M48235
Pathway	REACTOME_TRIGLYCERIDE_CATABOLISM	PPP1CA PPP1CC	6.88e-04	24	23	2	M10064
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	PPP1CA PPP1CC	8.08e-04	26	23	2	M628
Pubmed	Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma.	MKRN4P MKRN1	7.69e-07	2	31	2	19604354
Pubmed	The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans.	MKRN4P MKRN1	7.69e-07	2	31	2	16882727
Pubmed	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation.	MKRN4P MKRN1	7.69e-07	2	31	2	30143610
Pubmed	An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.	MKRN4P MKRN1	7.69e-07	2	31	2	12721631
Pubmed	Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.	PPP1CA PPP1CC	7.69e-07	2	31	2	9882500
Pubmed	PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.	PPP1CA PPP1CC	7.69e-07	2	31	2	23176181
Pubmed	Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals.	MKRN4P MKRN1	7.69e-07	2	31	2	16415359
Pubmed	The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.	MKRN4P MKRN1	2.31e-06	3	31	2	10843807
Pubmed	The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.	PPP1CA PPP1CC	2.31e-06	3	31	2	12138106
Pubmed	Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.	PPP1CA PPP1CC	2.31e-06	3	31	2	7857673
Pubmed	Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.	MKRN4P MKRN1	2.31e-06	3	31	2	24336050
Pubmed	Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.	PPP1CA PPP1CC	2.31e-06	3	31	2	11739654
Pubmed	Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.	PPP1CA PPP1CC	2.31e-06	3	31	2	19074462
Pubmed	Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.	PPP1CA PPP1CC	2.31e-06	3	31	2	11588169
Pubmed	Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF.	MKRN4P MKRN1	2.31e-06	3	31	2	23104211
Pubmed	1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.	PPP1CA PPP1CC	2.31e-06	3	31	2	25073485
Pubmed	Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.	PPP1CA PPP1CC	2.31e-06	3	31	2	21712997
Pubmed	NOM1 targets protein phosphatase I to the nucleolus.	PPP1CA PPP1CC	2.31e-06	3	31	2	17965019
Pubmed	Characterization of protein phosphatases in mouse oocytes.	PPP1CA PPP1CC	2.31e-06	3	31	2	9882488
Pubmed	Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.	PPP1CA PPP1CC	4.61e-06	4	31	2	23499489
Pubmed	Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.	PPP1CA PPP1CC	4.61e-06	4	31	2	16131488
Pubmed	Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.	PPP1CA PPP1CC	4.61e-06	4	31	2	10194355
Pubmed	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.	PPP1CA PPP1CC	4.61e-06	4	31	2	23277204
Pubmed	NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.	PPP1CA PPP1CC	4.61e-06	4	31	2	10880350
Pubmed	Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.	MKRN4P MKRN1	4.61e-06	4	31	2	11597136
Pubmed	The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.	PPP1CA PPP1CC	4.61e-06	4	31	2	12016225
Pubmed	Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.	PPP1CA PPP1CC	4.61e-06	4	31	2	12221103
Pubmed	Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.	PPP1CA PPP1CC	4.61e-06	4	31	2	15226296
Pubmed	Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.	PPP1CA PPP1CC	4.61e-06	4	31	2	22768081
Pubmed	Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.	PPP1CA PPP1CC	4.61e-06	4	31	2	12226088
Pubmed	Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.	PPP1CA PPP1CC	4.61e-06	4	31	2	17202132
Pubmed	Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.	PPP1CA PPP1CC	4.61e-06	4	31	2	10807923
Pubmed	A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.	PPP1CA PPP1CC	4.61e-06	4	31	2	12036952
Pubmed	N-CoR controls differentiation of neural stem cells into astrocytes.	PPP1CA PPP1CC	4.61e-06	4	31	2	12410313
Pubmed	Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.	PPP1CA PPP1CC	4.61e-06	4	31	2	24902662
Pubmed	Nuclear protein phosphatase-1 regulates HIV-1 transcription.	PPP1CA PPP1CC	4.61e-06	4	31	2	12788939
Pubmed	SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.	PPP1CA PPP1CC	7.68e-06	5	31	2	20424263
Pubmed	Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.	PPP1CA PPP1CC	7.68e-06	5	31	2	23197154
Pubmed	Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.	PPP1CA PPP1CC	7.68e-06	5	31	2	12624094
Pubmed	Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.	PPP1CA PPP1CC	7.68e-06	5	31	2	19581931
Pubmed	The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.	PPP1CA PPP1CC	7.68e-06	5	31	2	12016208
Pubmed	Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.	PPP1CA PPP1CC	7.68e-06	5	31	2	22801782
Pubmed	Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.	PPP1CA PPP1CC	7.68e-06	5	31	2	11551964
Pubmed	The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.	PPP1CA PPP1CC	7.68e-06	5	31	2	28615442
Pubmed	Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.	PPP1CA PPP1CC	7.68e-06	5	31	2	10209101
Pubmed	The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.	PPP1CA PPP1CC	7.68e-06	5	31	2	17511879
Pubmed	A PP1-PP2A phosphatase relay controls mitotic progression.	PPP1CA PPP1CC	7.68e-06	5	31	2	25487150
Pubmed	The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.	PPP1CA PPP1CC	7.68e-06	5	31	2	24116158
Pubmed	A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.	LHX2 ISL1	1.15e-05	6	31	2	9192866
Pubmed	Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).	PPP1CA PPP1CC	1.15e-05	6	31	2	25785436
Pubmed	Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.	PPP1CA PPP1CC	1.15e-05	6	31	2	21998301
Pubmed	Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.	MKRN4P MKRN1	1.15e-05	6	31	2	19536131
Pubmed	Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.	PPP1CA PPP1CC	1.15e-05	6	31	2	23088536
Pubmed	Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.	PPP1CA PPP1CC	1.15e-05	6	31	2	18641122
Pubmed	SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.	PPP1CA PPP1CC	1.15e-05	6	31	2	14640981
Pubmed	Differential expression of LIM-homeodomain genes in the embryonic murine brain.	LHX2 ISL1	1.15e-05	6	31	2	8817562
Pubmed	CIN85 interacting proteins in B cells-specific role for SHIP-1.	RTKN2 PPP1CA PPP1CC	1.54e-05	54	31	3	21725061
Pubmed	GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.	LHX2 ISL1	1.61e-05	7	31	2	18577233
Pubmed	Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.	PPP1CA PPP1CC	1.61e-05	7	31	2	18689497
Pubmed	SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.	PPP1CA PPP1CC	1.61e-05	7	31	2	17123353
Pubmed	Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.	LAMB2 ISL1	1.61e-05	7	31	2	17418794
Pubmed	Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.	PPP1CA PPP1CC	1.61e-05	7	31	2	33537097
Pubmed	A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.	PPP1CA PPP1CC	1.61e-05	7	31	2	12147701
Pubmed	Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.	PPP1CA PPP1CC	1.61e-05	7	31	2	10637318
Pubmed	A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.	PPP1CA PPP1CC	2.15e-05	8	31	2	12036313
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP1CA PPP1CC	2.15e-05	8	31	2	16262633
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	PPP1CA PPP1CC	2.15e-05	8	31	2	21930935
Pubmed	Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.	MKRN4P MKRN1	2.15e-05	8	31	2	15522233
Pubmed	Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.	LHX2 ISL1	2.76e-05	9	31	2	24643061
Pubmed	RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.	PPP1CA PPP1CC	2.76e-05	9	31	2	20926688
Pubmed	Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.	PPP1CA PPP1CC	2.76e-05	9	31	2	21566083
Pubmed	The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.	LHX2 ISL1	3.44e-05	10	31	2	30843071
Pubmed	Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons.	LHX2 ISL1	3.44e-05	10	31	2	11502254
Pubmed	Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation.	LHX2 ISL1	4.21e-05	11	31	2	11944941
Pubmed	BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.	LHX2 ISL1	4.21e-05	11	31	2	22609550
Pubmed	Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.	LHX2 ISL1	5.05e-05	12	31	2	16234809
Pubmed	RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.	LHX2 ISL1	5.05e-05	12	31	2	10431247
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PPP1CA PPP1CC	5.05e-05	12	31	2	10830164
Pubmed	Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons.	LHX2 ISL1	5.96e-05	13	31	2	9315901
Pubmed	The expression analysis of Sfrs10 and Celf4 during mouse retinal development.	LAMB2 ISL1	5.96e-05	13	31	2	23932931
Pubmed	Tlx controls proliferation and patterning of lateral telencephalic progenitor domains.	LHX2 ISL1	5.96e-05	13	31	2	14627641
Pubmed	Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.	LHX2 ISL1	5.96e-05	13	31	2	11877374
Pubmed	Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus.	LHX2 ISL1	5.96e-05	13	31	2	11306624
Pubmed	Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.	LHX2 ISL1	5.96e-05	13	31	2	22159578
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP1CA PPP1CC	6.95e-05	14	31	2	16048649
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	TRANK1 OPA1 HPR KCMF1 PPP1CA	7.30e-05	497	31	5	36774506
Pubmed	BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.	PPP1CA PPP1CC	8.02e-05	15	31	2	12931191
Pubmed	Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.	LHX2 ISL1	8.02e-05	15	31	2	9230312
Pubmed	Transcriptional ontogeny of the developing liver.	MKRN4P MKRN1	8.02e-05	15	31	2	22260730
Pubmed	BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord.	LHX2 ISL1	9.16e-05	16	31	2	22307612
Pubmed	Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance.	PPP1CA PPP1CC	9.16e-05	16	31	2	17683050
Pubmed	Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification.	LHX2 ISL1	9.16e-05	16	31	2	10693795
Pubmed	Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.	SFI1 PPP1CA	9.16e-05	16	31	2	29764992
Pubmed	Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.	LHX2 ISL1	9.16e-05	16	31	2	24333658
Pubmed	Proprioceptor pathway development is dependent on Math1.	LHX2 ISL1	9.16e-05	16	31	2	11395003
Pubmed	Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.	PPP1CA PPP1CC	9.16e-05	16	31	2	36484700
Pubmed	Boc is a receptor for sonic hedgehog in the guidance of commissural axons.	LHX2 ISL1	9.16e-05	16	31	2	17086203
Pubmed	Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb.	LHX2 ISL1	9.16e-05	16	31	2	19109910
Pubmed	Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord.	LHX2 ISL1	9.16e-05	16	31	2	11502253
Pubmed	Contribution of Hox genes to the diversity of the hindbrain sensory system.	LHX2 ISL1	1.04e-04	17	31	2	14960494
Interaction	PPP1R2C interactions	PPP1CA PPP1CC	1.37e-05	4	31	2	int:PPP1R2C
Interaction	CSRNP2 interactions	PPP1CA PPP1CC	2.28e-05	5	31	2	int:CSRNP2
Interaction	RASSF9 interactions	KCMF1 PPP1CA PPP1CC	2.90e-05	39	31	3	int:RASSF9
Interaction	SFRP5 interactions	PPP1CA PPP1CC	3.42e-05	6	31	2	int:SFRP5
Interaction	BCL9L interactions	LHX2 ISL1 PPP1CA	5.44e-05	48	31	3	int:BCL9L
GeneFamily	LIM class homeoboxes	LHX2 ISL1	8.42e-05	12	21	2	522
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP1CA PPP1CC	9.95e-05	13	21	2	693
Disease	mood instability measurement	LAMB2 TMEM120B HTR4 NCOA5	8.48e-06	128	30	4	EFO_0008475
Disease	periprosthetic osteolysis, disease progression measurement	CEMIP OTUD7A	1.04e-04	15	30	2	EFO_0008336, EFO_0009761
Disease	congestive heart failure (biomarker_via_orthology)	OPA1 HPR PPP1CC	1.75e-04	107	30	3	DOID:6000 (biomarker_via_orthology)
Disease	chronic kidney disease (biomarker_via_orthology)	OPA1 HPR	3.72e-04	28	30	2	DOID:784 (biomarker_via_orthology)
Disease	cholesterol in very small VLDL measurement	TDRD15 HPR	7.61e-04	40	30	2	EFO_0022231
Disease	free cholesterol in medium LDL measurement	TDRD15 HPR	7.61e-04	40	30	2	EFO_0022268
Disease	triglycerides in large LDL measurement	TDRD15 HPR	8.79e-04	43	30	2	EFO_0022319
Disease	cholesterol in medium VLDL measurement	TDRD15 HPR	9.21e-04	44	30	2	EFO_0022225
Disease	concentration of large LDL particles measurement	TDRD15 HPR	9.21e-04	44	30	2	EFO_0022160
Disease	free cholesterol in very small VLDL measurement	TDRD15 HPR	1.05e-03	47	30	2	EFO_0022275
Disease	phospholipids in medium LDL measurement	TDRD15 HPR	1.14e-03	49	30	2	EFO_0022183
Disease	free cholesterol in LDL measurement	TDRD15 HPR	1.19e-03	50	30	2	EFO_0022266
Disease	free cholesterol in large LDL measurement	TDRD15 HPR	1.24e-03	51	30	2	EFO_0022176
Disease	phospholipids in IDL measurement	TDRD15 HPR	1.28e-03	52	30	2	EFO_0022164
Disease	total lipids in LDL measurement	TDRD15 HPR	1.28e-03	52	30	2	EFO_0022308
Disease	free cholesterol in small LDL measurement	TDRD15 HPR	1.33e-03	53	30	2	EFO_0022271
Disease	phospholipids in large LDL measurement	TDRD15 HPR	1.33e-03	53	30	2	EFO_0022174
Disease	total lipids in medium VLDL	TDRD15 HPR	1.38e-03	54	30	2	EFO_0022153
Disease	triglycerides in medium VLDL measurement	TDRD15 HPR	1.44e-03	55	30	2	EFO_0022155
Disease	triglycerides in LDL measurement	TDRD15 HPR	1.49e-03	56	30	2	EFO_0022320
Disease	free cholesterol to total lipids in large HDL percentage	TDRD15 NCOA5	1.49e-03	56	30	2	EFO_0022279
Disease	parental longevity	LAMB2 SFI1 CEMIP OTUD7A	1.51e-03	494	30	4	EFO_0007796
Disease	total lipids in large LDL	TDRD15 HPR	1.54e-03	57	30	2	EFO_0022163
Disease	cholesterol in large LDL measurement	TDRD15 HPR	1.54e-03	57	30	2	EFO_0021901
Disease	phospholipids in LDL measurement	TDRD15 HPR	1.59e-03	58	30	2	EFO_0022294
Disease	phospholipids in small LDL measurement	TDRD15 HPR	1.65e-03	59	30	2	EFO_0022297
Disease	phospholipids in VLDL measurement	TDRD15 HPR	1.65e-03	59	30	2	EFO_0022301
Disease	total lipids in IDL	TDRD15 HPR	1.71e-03	60	30	2	EFO_0022161
Disease	total lipids in VLDL measurement	TDRD15 HPR	1.71e-03	60	30	2	EFO_0022314
Disease	free cholesterol in VLDL measurement	TDRD15 HPR	1.76e-03	61	30	2	EFO_0022276
Disease	triglycerides in medium LDL measurement	TDRD15 HPR	1.82e-03	62	30	2	EFO_0022322
Disease	cholesterol in large VLDL measurement	TDRD15 HPR	2.00e-03	65	30	2	EFO_0021902

Protein segments in the cluster

Peptide	Gene	Start	Entry
YERGRIYFDNYRRCV	DCAF17	61	Q5H9S7
RCSTYFLRYKNCRRF	CHCHD7	36	Q9BUK0
CDSRFAYRYPDCKYN	DIPK2B	416	Q9H7Y0
FRDAGCQFRALYCYY	CAMSAP1	1516	Q5T5Y3
QDYRFACYDRGRACR	CEMIP	381	Q8WUJ3
KIIYRRYAGLYFCIC	AP2S1	56	P53680
KYFQRGCCVYGDRCR	MKRN4P	126	Q13434
VKRLRYCEYLGKYFC	RUBCNL	446	Q9H714
EHLFRYQCKNYYRLR	HPR	46	P00739
CYLRALDRCYTSYRK	HMGCS2	261	P54868
YCRRKDDSYFDRYRD	NCOA5	136	Q9HCD5
YYALYELVVRGNCFC	LAMB2	271	P55268
YCKEDYYRRFSVQRC	LHX2	101	P50458
YCSYCYREELRRRRE	OTUD7A	906	Q8TE49
NRIYGFYDECKRRYN	PPP1CA	131	P62136
NHCNLCRRGFYYYQR	OPA1	851	O60313
LDRYYAICCQPLVYR	HTR4	116	Q13639
NFRGRRYKCLICYDY	KCMF1	16	Q9P0J7
KYFQRGYCIYGDRCR	MKRN1	91	Q9UHC7
RRLYCVLRGGKLYCF	RTKN2	306	Q8IZC4
LCVRADCHYRYYLYN	SFI1	141	A8K8P3
RCERCGKVFTYKYYR	PRDM14	401	Q9GZV8
FLQYYYQRGCLYRLR	TMEM120B	231	A0PK00
LFCCARYSKDRRFYR	TDRD15	536	B5MCY1
DRRCLKNYQYVCYLF	SLC16A12	341	Q6ZSM3
YCKRDYIRLYGIKCA	ISL1	66	P61371
GGSYMCHRSYCYRYR	SUMF1	331	Q8NBK3
ERGYCCIYCRRGNRY	TNMD	261	Q9H2S6
NRIYGFYDECKRRYN	PPP1CC	131	P36873
YFYKRSQCYKDAFRC	TRANK1	1801	O15050
YRPLRCYMYKLGFCR	TTLL1	206	O95922