Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	amide transmembrane transporter activity	SLC38A7 ABCC5 ABCD1	1.78e-04	42	52	3	GO:0042887
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	7.38e-06	187	52	6	GO:0007156
Domain	Cadherin_tail	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	7.52e-10	37	52	6	PF15974
Domain	Cadherin_CBD	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	7.52e-10	37	52	6	IPR031904
Domain	Cadherin_C_2	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	1.68e-09	42	52	6	PF16492
Domain	Cadherin_C	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	1.68e-09	42	52	6	IPR032455
Domain	Cadherin_N	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	2.52e-08	65	52	6	IPR013164
Domain	Cadherin_2	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	2.52e-08	65	52	6	PF08266
Domain	Cadherin_CS	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	5.63e-07	109	52	6	IPR020894
Domain	Cadherin	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	6.96e-07	113	52	6	PF00028
Domain	CADHERIN_1	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	6.96e-07	113	52	6	PS00232
Domain	CADHERIN_2	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	7.34e-07	114	52	6	PS50268
Domain	-	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	7.34e-07	114	52	6	2.60.40.60
Domain	CA	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	7.72e-07	115	52	6	SM00112
Domain	Cadherin-like	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	8.13e-07	116	52	6	IPR015919
Domain	Cadherin	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	8.99e-07	118	52	6	IPR002126
Domain	LEM/LEM-like_dom	LEMD2 ANKLE2	1.58e-04	7	52	2	IPR011015
Domain	LEM_dom	LEMD2 ANKLE2	1.58e-04	7	52	2	IPR003887
Domain	LEM	LEMD2 ANKLE2	1.58e-04	7	52	2	PS50954
Domain	-	LEMD2 ANKLE2	1.58e-04	7	52	2	1.10.720.40
Domain	LEM	LEMD2 ANKLE2	1.58e-04	7	52	2	PF03020
Domain	Ion_trans_dom	TPTE2 KCNMA1 HVCN1 CNGA3	2.84e-04	114	52	4	IPR005821
Domain	Ion_trans	TPTE2 KCNMA1 HVCN1 CNGA3	2.84e-04	114	52	4	PF00520
Domain	IQ	IQCF5 MYO9A MYH14	1.02e-03	71	52	3	PF00612
Domain	IQ	IQCF5 MYO9A MYH14	1.49e-03	81	52	3	SM00015
Domain	IQ_motif_EF-hand-BS	IQCF5 MYO9A MYH14	2.02e-03	90	52	3	IPR000048
Domain	IQ	IQCF5 MYO9A MYH14	2.21e-03	93	52	3	PS50096
Domain	ABC_TM1F	ABCC5 ABCD1	2.74e-03	28	52	2	PS50929
Domain	ABC1_TM_dom	ABCC5 ABCD1	2.74e-03	28	52	2	IPR011527
Domain	MYOSIN_MOTOR	MYO9A MYH14	5.01e-03	38	52	2	PS51456
Domain	Myosin_head	MYO9A MYH14	5.01e-03	38	52	2	PF00063
Domain	Myosin_head_motor_dom	MYO9A MYH14	5.01e-03	38	52	2	IPR001609
Domain	MYSc	MYO9A MYH14	5.01e-03	38	52	2	SM00242
Domain	ABC_transporter_CS	ABCC5 ABCD1	6.10e-03	42	52	2	IPR017871
Domain	ABC_TRANSPORTER_2	ABCC5 ABCD1	7.90e-03	48	52	2	PS50893
Domain	ABC_tran	ABCC5 ABCD1	7.90e-03	48	52	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCC5 ABCD1	8.22e-03	49	52	2	PS00211
Domain	ABC_transporter-like	ABCC5 ABCD1	8.55e-03	50	52	2	IPR003439
Domain	P-loop_NTPase	MYO9A MYH14 RAB40AL ABCC5 ABCD1 GAL3ST2 DHX34	8.75e-03	848	52	7	IPR027417
Domain	Channel_four-helix_dom	TPTE2 HVCN1	1.10e-02	57	52	2	IPR027359
Domain	-	TPTE2 HVCN1	1.10e-02	57	52	2	1.20.120.350
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	2.21e-11	15	54	5	23515096
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	7.14e-10	28	54	5	15347688
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	1.07e-09	68	54	6	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	1.52e-09	72	54	6	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	1.80e-09	74	54	6	10817752
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	2.01e-09	34	54	5	22884324
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	2.29e-09	77	54	6	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	2.89e-09	80	54	6	10716726
Pubmed	A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	7.74e-09	44	54	5	19029045
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	2.94e-08	57	54	5	32633719
Pubmed	Differential expression of individual gamma-protocadherins during mouse brain development.	PCDHGA12 PCDHGA4 PCDHGA3	1.23e-07	7	54	3	15964765
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	2.07e-06	58	54	4	30377227
Pubmed	Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity.	MPO HVCN1	7.09e-06	3	54	2	25885273
Pubmed	Defining the membrane proteome of NK cells.	MAGED2 SPN MYH14 LEMD2 ABCD1 LTB4R2 CD320 ANKLE2 DHX34 PIGO	1.10e-05	1168	54	10	19946888
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	IQCF5 MAGED2 MYH14 PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 ABCC5 ANKLE2	1.11e-05	1442	54	11	35575683
Pubmed	LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist.	LEMD2 ANKLE2	1.42e-05	4	54	2	28684548
Pubmed	Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE.	TPTE2 KCNMA1	2.36e-05	5	54	2	28498403
Pubmed	Repair of nuclear ruptures requires barrier-to-autointegration factor.	LEMD2 ANKLE2	3.54e-05	6	54	2	31147383
Pubmed	Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.	PCDHGA12 PCDHGA6	8.46e-05	9	54	2	19956686
Pubmed	Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.	JAG2 DTX1	1.55e-04	12	54	2	15465494
Pubmed	Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.	MYO9A MYH14	2.13e-04	14	54	2	8022818
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FZD1 JAG2 LONRF1 ABCD1 DHX34 ADCY7 ANO8 MXRA7	2.88e-04	1105	54	8	35748872
Pubmed	Lunatic fringe null female mice are infertile due to defects in meiotic maturation.	JAG2 PTGER2	3.56e-04	18	54	2	15659488
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCC5 ABCD1	5.86e-04	23	54	2	10708515
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	SEC22C PCDHGA12 PPCDC CD320 HVCN1 PCSK4 PIGO	7.95e-04	985	54	7	12975309
Pubmed	Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.	LTB4R2 PTGER2	8.10e-04	27	54	2	23624557
Pubmed	Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice.	PCDHGA7 PCDHGA3	8.72e-04	28	54	2	33523829
Pubmed	pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.	FZD1 JAG2	1.00e-03	30	54	2	17257418
Pubmed	The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.	B3GALT4 CD320	1.07e-03	31	54	2	26618355
Pubmed	Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.	LTB4R2 PTGER2	1.21e-03	33	54	2	39002541
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	PCDHGA4 CD320 DHX34 TPBG	1.33e-03	307	54	4	37499664
Pubmed	Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.	B3GALT4 CD320	1.44e-03	36	54	2	15112104
Interaction	PCDHGA4 interactions	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	3.14e-10	34	53	6	int:PCDHGA4
Interaction	PCDHGA7 interactions	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4	5.29e-09	25	53	5	int:PCDHGA7
Interaction	PCDHGA6 interactions	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4	4.36e-07	24	53	4	int:PCDHGA6
Interaction	PCDHGA9 interactions	PCDHGA12 PCDHGA5 PCDHGA4 PCDHGA3	1.65e-06	33	53	4	int:PCDHGA9
Interaction	PCDHGA12 interactions	PCDHGA12 PCDHGA7 PCDHGA4	2.03e-06	10	53	3	int:PCDHGA12
Interaction	SLC30A2 interactions	TNFRSF12A SLC38A7 ABCC5 ANKLE2 PIGO	7.12e-06	102	53	5	int:SLC30A2
Interaction	ATP2B2 interactions	PCDHGA7 SPRING1 LEMD2 ABCD1 GAL3ST2 PIGO	1.30e-05	198	53	6	int:ATP2B2
Interaction	PCDHGA5 interactions	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4	2.26e-05	63	53	4	int:PCDHGA5
Interaction	ATP2A3 interactions	PCDHGA5 LEMD2 ABCD1 ANKLE2 CNGA3 PIGO	3.19e-05	232	53	6	int:ATP2A3
Interaction	PCDHGA8 interactions	PCDHGA5 PCDHGA4	6.75e-05	5	53	2	int:PCDHGA8
Interaction	PCDHA9 interactions	PCDHGA12 PCDHGA6 PCDHGA4	8.07e-05	32	53	3	int:PCDHA9
Interaction	H2BC5 interactions	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	2.25e-04	331	53	6	int:H2BC5
Interaction	PCDHGA3 interactions	PCDHGA4 PCDHGA3	2.41e-04	9	53	2	int:PCDHGA3
Cytoband	5q31	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	5.07e-09	115	54	6	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	1.41e-06	298	54	6	chr5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr12q24	NAA25 DTX1 SPRING1 ANKLE2 HVCN1	1.29e-04	415	54	5	chr12q24
Cytoband	12q24.13	NAA25 DTX1	4.00e-04	25	54	2	12q24.13
GeneFamily	Clustered protocadherins	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	6.32e-09	64	41	6	20
GeneFamily	LEM domain containing	LEMD2 ANKLE2	1.05e-04	7	41	2	1087
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	TNFRSF12A SPN CD320 FCAMR	1.19e-02	394	41	4	471
Coexpression	GSE32423_IL7_VS_IL4_MEMORY_CD8_TCELL_UP	TNFRSF12A SEC22C SPN ABCC5 HVCN1 ADCY7	3.49e-06	200	54	6	M5093
Coexpression	GSE30083_SP1_VS_SP4_THYMOCYTE_DN	SPN DTX1 ABCD1 HVCN1 ADCY7	5.74e-05	200	54	5	M5030
Coexpression	GSE30083_SP1_VS_SP3_THYMOCYTE_DN	DTX1 ABCD1 PTGER2 HVCN1 FCAMR	5.74e-05	200	54	5	M5026
Coexpression	GSE7852_LN_VS_THYMUS_TREG_UP	SPN PTGER2 ANKLE2 HVCN1 ADCY7	5.74e-05	200	54	5	M5737
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JAG2 TNFRSF12A LTB4R2 MXRA7 TPBG	4.17e-06	198	54	5	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
Disease	Sarcosine measurement	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	4.58e-10	23	52	5	EFO_0021668
Disease	mental development measurement	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	7.22e-10	25	52	5	EFO_0008230
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3	2.92e-09	71	52	6	EFO_0007878, EFO_0007979
Disease	lymphocyte count	PLXDC1 PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 ABCC5 PPCDC ABCD1 ANKLE2	3.98e-05	1464	52	11	EFO_0004587
Disease	2-hydroxyglutarate measurement	PLD5 GAL3ST2	3.60e-04	16	52	2	EFO_0021506
Disease	mean platelet volume	PCDHGA12 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 ABCC5 HSD11B2	3.87e-04	1020	52	8	EFO_0004584
Disease	Carcinoma, Pancreatic Ductal	JAG2 DTX1	8.20e-04	24	52	2	C0887833
Disease	coffee consumption	NAA25 PPCDC	1.46e-03	32	52	2	EFO_0004330
Disease	Growth Disorders	RAB40AL KCNMA1	1.85e-03	36	52	2	C0018273
Disease	eye disease	PCDHGA5 KCNMA1	2.87e-03	45	52	2	EFO_0003966

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASVLLIAVRWLVRRL	ANKLE2	21	Q86XL3
LKAVWLGRLRLTRLL	ANKRD34C	16	P0C6C1
FRRLLLAALLLVIVW	B3GALT4	6	O96024
ECLLRRWLRALALLT	ADCY7	86	P51828
AWLLVAARALLQLLR	HSD11B2	11	P80365
WELARALLGLLSLRR	ANO8	506	Q9HCE9
ARIVLLRHRLNWLGR	RAB40AL	171	P0C0E4
AFVLVLLALRLRRWH	PCDHGA7	706	Q9Y5G6
LLALRLRRWHKSRLL	PCDHGA7	711	Q9Y5G6
AFVIVLLVLRLRRWH	PCDHGA5	706	Q9Y5G8
LLVLRLRRWHKSRLL	PCDHGA5	711	Q9Y5G8
AFVILLLALRLRRWH	PCDHGA12	706	O60330
LLALRLRRWHKSRLL	PCDHGA12	711	O60330
LWLLRLLFPRVLCRE	ABCD1	76	P33897
LAFVTVLLALKLRRW	PCDHGA4	736	Q9Y5G9
LLALRLQRWHKSRLL	PCDHGA6	711	Q9Y5G7
RTRLAAWARRALLSL	MAGED2	231	Q9UNF1
RSWLGLRFLRALRLI	KCNMA1	266	Q12791
AVIVLVALLLLWRRR	SPN	266	P16150
EVGRRLERWLSRLLL	LEMD2	201	Q8NC56
LAVLRISLLGRSWLL	LCN12	141	Q6JVE5
RRLLLLLALWVQAAR	JAG2	11	Q9Y219
ERWELLLRRGELLAL	LONRF1	46	Q17RB8
TLLLLSWLRAQERLR	CD320	246	Q9NPF0
EALGLLILLRLWRVA	HVCN1	196	Q96D96
LILLRLWRVARIING	HVCN1	201	Q96D96
LFRWLVLRLNRALDR	MYH14	451	Q7Z406
IALWLRLVLALALVR	PCSK4	6	Q6UW60
VLGNLIALALLARRW	PTGER2	36	P43116
VALDLLERKLRSLWR	MPO	121	P05164
LVRRTLLHAALRAWI	IQCF5	26	A8MTL0
KVLRLLITAWERRLI	DTX1	546	Q86Y01
VLGSLIWLRRVYLLR	IGF2BP2-AS1	91	Q96M15
AFVIVLLALRLRRWH	PCDHGA3	706	Q9Y5H0
LLALRLRRWHKSRLL	PCDHGA3	711	Q9Y5H0
RWLAVRLDLISIALI	ABCC5	1096	O15440
VDPRRLARQLLLLLW	FZD1	46	Q9UP38
DESLVLLRRRLRWAL	GAL3ST2	231	Q9H3Q3
LLLLWRQVVGFRRLV	CROCC	296	Q5TZA2
ALVLLQRKLWRRRTS	FCAMR	466	Q8WWV6
AIRLLAASLRLRARW	DHX34	936	Q14147
LEWRRRLKSLALRLA	SEC22C	31	Q9BRL7
TRRRVRALIAVLWAV	MLNR	151	O43193
RLLRKRWVLALVFGL	SPRING1	11	Q9H741
LVLRSVRVRLLLSFW	PLD5	371	Q8N7P1
RPLLLSLLRRVRWLD	RNF151	176	Q2KHN1
ALARRLLLAVWLAAL	LTB4R2	136	Q9NPC1
LLWLELLRRLRTGNL	PRODH	581	O43272
ERRRRVLQTLVWFLL	SLC38A7	366	Q9NVC3
ARLSRLIFLLRRWAA	CNGA3	71	Q16281
VLHIDLRRWADLLLV	PPCDC	86	Q96CD2
LRRLLRLLVLGLWLA	TNFRSF12A	6	Q9NP84
RLLVLGLWLALLRSV	TNFRSF12A	11	Q9NP84
ALVALLAAVRLWLRR	PIGO	676	Q8TEQ8
RWTHLVRLLRLIILI	TPTE2	171	Q6XPS3
LRLARLALVLLGWVS	TPBG	16	Q13641
WLLVLVLREAARALS	PLXDC1	6	Q8IUK5
TALALLLAWLLVRRG	MXRA7	16	P84157
RRIILLQRWFRVLLC	MYO9A	1021	B2RTY4
WLRIRSLTLRLISGL	NAA25	686	Q14CX7