Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor activity	GABRA1 GABRA2 GABRA3	8.22e-06	11	75	3	GO:0008503
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRA1 GABRA2 GABRA3	3.99e-05	18	75	3	GO:0022851
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRA1 GABRA2 GABRA3	4.72e-05	19	75	3	GO:0004890
GeneOntologyMolecularFunction	GABA receptor activity	GABRA1 GABRA2 GABRA3	7.45e-05	22	75	3	GO:0016917
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GABRA1 GABRA2 GABRA3	9.73e-05	24	75	3	GO:0099507
GeneOntologyMolecularFunction	transcription coregulator activity	PTPN14 BCLAF1 DYRK1B MED12L DYRK1A ACTL6A TADA2A CREBBP DDX1	2.50e-04	562	75	9	GO:0003712
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	CUL3 PTPN14 BCLAF1 DYRK1B MED12L DYRK1A AP1M1 ACTL6A TADA2A KBTBD2 CREBBP ARPC4 DDX1	3.51e-04	1160	75	13	GO:0030674
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	BRAF DYRK1B DYRK1A	7.33e-04	47	75	3	GO:0004712
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	GABRA1 GABRA2 GABRA3	8.79e-04	50	75	3	GO:0099095
GeneOntologyMolecularFunction	transcription coactivator activity	DYRK1B MED12L DYRK1A ACTL6A TADA2A CREBBP	9.72e-04	303	75	6	GO:0003713
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRA1 GABRA2 GABRA3	1.29e-03	57	75	3	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GABRA1 GABRA2 GABRA3	1.49e-03	60	75	3	GO:0099529
GeneOntologyMolecularFunction	molecular adaptor activity	CUL3 PTPN14 BCLAF1 DYRK1B MED12L DYRK1A AP1M1 ACTL6A TADA2A KBTBD2 CREBBP ARPC4 DDX1	1.50e-03	1356	75	13	GO:0060090
GeneOntologyMolecularFunction	transmitter-gated channel activity	GABRA1 GABRA2 GABRA3	1.88e-03	65	75	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GABRA1 GABRA2 GABRA3	1.88e-03	65	75	3	GO:0022824
GeneOntologyCellularComponent	intracellular protein-containing complex	DOCK1 CUL3 LIG4 ATG3 CCDC47 PIH1D2 ACTL6A TADA2A TAF2 ELP3 CREBBP TRAPPC2L DDX1	3.28e-05	972	74	13	GO:0140535
GeneOntologyCellularComponent	GABA-A receptor complex	GABRA1 GABRA2 GABRA3	3.96e-05	19	74	3	GO:1902711
GeneOntologyCellularComponent	GABA receptor complex	GABRA1 GABRA2 GABRA3	5.41e-05	21	74	3	GO:1902710
GeneOntologyCellularComponent	histone acetyltransferase complex	ACTL6A TADA2A TAF2 CREBBP	3.47e-04	94	74	4	GO:0000123
GeneOntologyCellularComponent	protein acetyltransferase complex	ACTL6A TADA2A TAF2 CREBBP	5.09e-04	104	74	4	GO:0031248
GeneOntologyCellularComponent	inner dynein arm	DNAI7 DNAH1	5.46e-04	10	74	2	GO:0036156
GeneOntologyCellularComponent	acetyltransferase complex	ACTL6A TADA2A TAF2 CREBBP	6.08e-04	109	74	4	GO:1902493
GeneOntologyCellularComponent	dendrite membrane	GABRA1 GABRA2 GABRA3	1.03e-03	56	74	3	GO:0032590
GeneOntologyCellularComponent	chloride channel complex	GABRA1 GABRA2 GABRA3	1.09e-03	57	74	3	GO:0034707
HumanPheno	Short attention span	PPP1R21 LIG4 ZBTB20 MED12L DYRK1A SPG11 CREBBP YWHAG ARPC4 MAB21L1 GABRA1 GABRA2	2.43e-05	517	31	12	HP:0000736
HumanPheno	Reduced attention regulation	PPP1R21 LIG4 ZBTB20 MED12L DYRK1A SPG11 CREBBP YWHAG ARPC4 MAB21L1 GABRA1 GABRA2	2.90e-05	526	31	12	HP:5200044
HumanPheno	Hyperactivity	CUL3 PPP1R21 LIG4 ZBTB20 MED12L DYRK1A CREBBP YWHAG ARPC4 MAB21L1 GABRA1 GABRA2	5.26e-05	558	31	12	HP:0000752
HumanPheno	Cerebral visual impairment	BRAF CCDC47 TBCK DOCK7 ARPC4 TRAPPC2L GABRA2	7.57e-05	179	31	7	HP:0100704
HumanPheno	Narrow forehead	PPP1R21 LIG4 BRAF CCDC47 TBCK DOCK7 DYRK1A	9.01e-05	184	31	7	HP:0000341
HumanPheno	Attention deficit hyperactivity disorder	PPP1R21 LIG4 ZBTB20 MED12L DYRK1A YWHAG ARPC4 MAB21L1 GABRA1 GABRA2	1.03e-04	413	31	10	HP:0007018
HumanPheno	Premature thelarche	BRAF DYRK1A CREBBP	1.31e-04	17	31	3	HP:0010314
HumanPheno	Abnormal pulmonary valve morphology	CUL3 BRAF DSG1 TBCK DYRK1A CREBBP ARPC4	1.43e-04	198	31	7	HP:0001641
HumanPheno	Pulmonic stenosis	CUL3 BRAF DSG1 TBCK CREBBP ARPC4	1.49e-04	138	31	6	HP:0001642
HumanPheno	Facial hypertrichosis	ZBTB20 CCDC47 TBCK DOCK7 CREBBP MAB21L1 GABRA3	1.83e-04	206	31	7	HP:0002219
Domain	GABAAa_rcpt	GABRA1 GABRA2 GABRA3	1.18e-06	6	74	3	IPR001390
Domain	MAGEA3/MAGEA6	MAGEA3 MAGEA6	1.55e-05	2	74	2	IPR030097
Domain	PDEase_PDE8	PDE8A PDE8B	1.55e-05	2	74	2	IPR013938
Domain	SNX5/SNX6/SNX32	SNX6 SNX32	4.63e-05	3	74	2	IPR014637
Domain	Teashirt_fam	TSHZ3 TSHZ2	4.63e-05	3	74	2	IPR027008
Domain	GABAA/Glycine_rcpt	GABRA1 GABRA2 GABRA3	9.99e-05	23	74	3	IPR006028
Domain	Vps5	SNX6 SNX32	1.54e-04	5	74	2	PF09325
Domain	Vps5_C	SNX6 SNX32	1.54e-04	5	74	2	IPR015404
Domain	Haem_d1	STXBP5 EML6	2.30e-04	6	74	2	IPR011048
Domain	Cullin	CUL3 CACUL1	6.83e-04	10	74	2	PF00888
Domain	CULLIN_2	CUL3 CACUL1	6.83e-04	10	74	2	PS50069
Domain	Cullin_N	CUL3 CACUL1	6.83e-04	10	74	2	IPR001373
Domain	CULLIN_1	CUL3 CACUL1	6.83e-04	10	74	2	PS01256
Domain	Neurotransmitter_ion_chnl_CS	GABRA1 GABRA2 GABRA3	7.52e-04	45	74	3	IPR018000
Domain	Neur_chan_memb	GABRA1 GABRA2 GABRA3	8.02e-04	46	74	3	PF02932
Domain	DOCK_C	DOCK1 DOCK7	8.32e-04	11	74	2	IPR010703
Domain	DHR-1_domain	DOCK1 DOCK7	8.32e-04	11	74	2	IPR027007
Domain	DHR_2	DOCK1 DOCK7	8.32e-04	11	74	2	PS51651
Domain	DHR_1	DOCK1 DOCK7	8.32e-04	11	74	2	PS51650
Domain	DOCK-C2	DOCK1 DOCK7	8.32e-04	11	74	2	PF14429
Domain	DHR-2	DOCK1 DOCK7	8.32e-04	11	74	2	IPR027357
Domain	DHR-2	DOCK1 DOCK7	8.32e-04	11	74	2	PF06920
Domain	DOCK	DOCK1 DOCK7	8.32e-04	11	74	2	IPR026791
Domain	Neur_chan_LBD	GABRA1 GABRA2 GABRA3	8.54e-04	47	74	3	PF02931
Domain	NEUROTR_ION_CHANNEL	GABRA1 GABRA2 GABRA3	8.54e-04	47	74	3	PS00236
Domain	Neurotrans-gated_channel_TM	GABRA1 GABRA2 GABRA3	8.54e-04	47	74	3	IPR006029
Domain	-	GABRA1 GABRA2 GABRA3	8.54e-04	47	74	3	2.70.170.10
Domain	Neur_channel	GABRA1 GABRA2 GABRA3	8.54e-04	47	74	3	IPR006201
Domain	Neur_chan_lig-bd	GABRA1 GABRA2 GABRA3	8.54e-04	47	74	3	IPR006202
Domain	Cullin_repeat-like_dom	CUL3 CACUL1	9.96e-04	12	74	2	IPR016159
Domain	Znf_ZZ	TADA2A CREBBP	2.54e-03	19	74	2	IPR000433
Domain	PDEase	PDE8A PDE8B	2.54e-03	19	74	2	IPR023088
Domain	ZnF_ZZ	TADA2A CREBBP	2.54e-03	19	74	2	SM00291
Domain	MAGE_N	MAGEA3 MAGEA6	2.81e-03	20	74	2	SM01392
Domain	PDEase_I	PDE8A PDE8B	3.10e-03	21	74	2	PF00233
Domain	PDEASE_I	PDE8A PDE8B	3.10e-03	21	74	2	PS00126
Domain	PDEase_CS	PDE8A PDE8B	3.10e-03	21	74	2	IPR023174
Domain	MAGE_N	MAGEA3 MAGEA6	3.40e-03	22	74	2	PF12440
Domain	-	PDE8A PDE8B	3.40e-03	22	74	2	1.10.1300.10
Domain	MAGE_N	MAGEA3 MAGEA6	3.40e-03	22	74	2	IPR021072
Domain	PDEase_catalytic_dom	PDE8A PDE8B	3.71e-03	23	74	2	IPR002073
Domain	HDc	PDE8A PDE8B	4.04e-03	24	74	2	SM00471
Domain	HD/PDEase_dom	PDE8A PDE8B	4.04e-03	24	74	2	IPR003607
Domain	PAS	PDE8A PDE8B	4.38e-03	25	74	2	PF00989
Domain	PAS_fold	PDE8A PDE8B	4.38e-03	25	74	2	IPR013767
Domain	HormR	CALCR ADGRB2	4.38e-03	25	74	2	SM00008
Domain	Longin-like_dom	AP1M1 TRAPPC2L	5.48e-03	28	74	2	IPR011012
Domain	HRM	CALCR ADGRB2	5.48e-03	28	74	2	PF02793
Domain	zf-C2H2	RLF ZNF384 TSHZ3 ZNF276 ZBTB20 TSHZ2 ZBTB47 ZNF121	6.02e-03	693	74	8	PF00096
Pathway	BIOCARTA_FLUMAZENIL_PATHWAY	GABRA1 GABRA2 GABRA3	2.04e-06	9	42	3	M22034
Pathway	BIOCARTA_GABA_PATHWAY	GABRA1 GABRA2 GABRA3	2.91e-06	10	42	3	M477
Pathway	BIOCARTA_GABA_PATHWAY	GABRA1 GABRA2 GABRA3	2.91e-06	10	42	3	MM1401
Pathway	WP_GABA_RECEPTOR_SIGNALING	GABRA1 GABRA2 GABRA3	1.04e-04	31	42	3	M39369
Pathway	WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION	GABRA1 GABRA2 GABRA3	1.93e-04	38	42	3	M39854
Pubmed	Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.	GABRA1 GABRA2 GABRA3	9.63e-09	3	75	3	16835366
Pubmed	Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits.	GABRA1 GABRA2 GABRA3	9.63e-09	3	75	3	15304513
Pubmed	The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development.	GABRA1 GABRA2 GABRA3	9.63e-09	3	75	3	1356407
Pubmed	Specific GABAA circuits for visual cortical plasticity.	GABRA1 GABRA2 GABRA3	9.63e-09	3	75	3	15017002
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MEMO1 RLF ZNF384 PTPN14 DSG1 CCDC47 PYGB AP1M1 RAI14 ACTL6A TAF2 ELP3 CREBBP YWHAG ARPC4 DDX1	2.47e-08	1353	75	16	29467282
Pubmed	Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.	GABRA1 GABRA2 GABRA3	3.85e-08	4	75	3	25865415
Pubmed	Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.	GABRA1 GABRA2 GABRA3	3.85e-08	4	75	3	25080596
Pubmed	The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development.	GABRA1 GABRA2 GABRA3	3.85e-08	4	75	3	26518133
Pubmed	GABA(A) receptor downregulation in brains of subjects with autism.	GABRA1 GABRA2 GABRA3	3.85e-08	4	75	3	18821008
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	CCDC47 BCLAF1 DOCK7 DYRK1A AP1M1 RAI14 ACTL6A ELP3 FMNL2 YWHAG DDX1	6.75e-08	601	75	11	33658012
Pubmed	Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.	GABRA1 GABRA2 GABRA3	9.60e-08	5	75	3	30104684
Pubmed	GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in mice.	GABRA1 GABRA2 GABRA3	1.92e-07	6	75	3	20457185
Pubmed	Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5.	GABRA1 GABRA2 GABRA3	1.92e-07	6	75	3	15033447
Pubmed	Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system.	GABRA1 GABRA2 GABRA3	3.35e-07	7	75	3	16101898
Pubmed	Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia.	GABRA1 GABRA2 GABRA3	3.35e-07	7	75	3	20843900
Pubmed	Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).	GABRA1 GABRA2 GABRA3	3.35e-07	7	75	3	35228700
Pubmed	gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.	GABRA1 GABRA2 GABRA3	5.35e-07	8	75	3	8175718
Pubmed	GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.	GABRA1 GABRA2 GABRA3	5.35e-07	8	75	3	11528422
Pubmed	Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons.	GABRA1 GABRA2 GABRA3	1.14e-06	10	75	3	36733270
Pubmed	Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.	GABRA1 GABRA2 GABRA3	1.14e-06	10	75	3	21789198
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	PTPN14 BRAF BCLAF1 DOCK7 DYRK1A RAI14 YWHAG	1.36e-06	255	75	7	15324660
Pubmed	Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis.	GABRA1 GABRA2 GABRA3	1.57e-06	11	75	3	9924185
Pubmed	Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.	GABRA1 GABRA2 GABRA3	1.57e-06	11	75	3	38894703
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	LIG4 SNX6 CCDC47 BCLAF1 DYRK1A RAI14 TADA2A DNAI7 CREBBP ZNF121	1.77e-06	670	75	10	22990118
Pubmed	Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.	GABRA1 GABRA2 GABRA3	2.09e-06	12	75	3	2561974
Pubmed	Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.	GABRA1 GABRA2 GABRA3	2.71e-06	13	75	3	22569571
Pubmed	Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning.	GABRA1 GABRA2 GABRA3	2.71e-06	13	75	3	22640814
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CUL3 PTPN14 PDE8A DDHD1 PTPRQ DOCK7 DYRK1A RAI14 FMNL2 CREBBP ARPC4 TRAPPC2L DDX1	4.57e-06	1321	75	13	27173435
Pubmed	cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.	PDE8A PDE8B	4.59e-06	2	75	2	22232524
Pubmed	Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward.	GABRA2 GABRA3	4.59e-06	2	75	2	22763624
Pubmed	Transient expression of GABAA receptor alpha2 and alpha3 subunits in differentiating cerebellar neurons.	GABRA2 GABRA3	4.59e-06	2	75	2	14766194
Pubmed	Molecular and neuronal substrate for the selective attenuation of anxiety.	GABRA2 GABRA3	4.59e-06	2	75	2	11021797
Pubmed	miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling.	MAGEA3 MAGEA6	4.59e-06	2	75	2	30056111
Pubmed	Consequences of prenatal exposure to diazepam on the respiratory parameters, respiratory network activity and gene expression of alpha1 and alpha2 subunits of GABA(A) receptor in newborn rat.	GABRA1 GABRA2	4.59e-06	2	75	2	18085262
Pubmed	Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens.	GABRA2 GABRA3	4.59e-06	2	75	2	24553732
Pubmed	Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling.	GABRA1 GABRA2	4.59e-06	2	75	2	21073549
Pubmed	The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.	PDE8A PDE8B	4.59e-06	2	75	2	21187369
Pubmed	Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.	DYRK1B DYRK1A	4.59e-06	2	75	2	34969768
Pubmed	Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.	GABRA2 GABRA3	4.59e-06	2	75	2	23147414
Pubmed	α2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations.	GABRA1 GABRA2	4.59e-06	2	75	2	23109109
Pubmed	Functional expression of the GABA(A) receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala.	GABRA2 GABRA3	4.59e-06	2	75	2	22666188
Pubmed	Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.	GABRA1 GABRA3	4.59e-06	2	75	2	23744069
Pubmed	Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers.	TSHZ3 TSHZ2	4.59e-06	2	75	2	21423795
Pubmed	Functional mapping of GABA A receptor subtypes in the amygdala.	GABRA2 GABRA3	4.59e-06	2	75	2	15341600
Pubmed	Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.	GABRA2 GABRA3	4.59e-06	2	75	2	8391122
Pubmed	Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.	GABRA1 GABRA2	4.59e-06	2	75	2	21056629
Pubmed	GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis.	GABRA1 GABRA2	4.59e-06	2	75	2	18973555
Pubmed	Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome.	MAGEA6 GABRA3	4.59e-06	2	75	2	31593956
Pubmed	Reversal of pathological pain through specific spinal GABAA receptor subtypes.	GABRA2 GABRA3	4.59e-06	2	75	2	18202657
Pubmed	A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence.	MAGEA3 MAGEA6	4.59e-06	2	75	2	25564441
Pubmed	Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.	PDE8A PDE8B	4.59e-06	2	75	2	12681444
Pubmed	Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.	DYRK1B DYRK1A	4.59e-06	2	75	2	30501876
Pubmed	Dissecting the role of diazepam-sensitive γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat.	GABRA2 GABRA3	4.59e-06	2	75	2	23067879
Pubmed	Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.	GABRA1 GABRA3	4.59e-06	2	75	2	9655866
Pubmed	Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.	GABRA2 GABRA3	4.59e-06	2	75	2	26973458
Pubmed	cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.	PDE8A PDE8B	4.59e-06	2	75	2	36277728
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	RLF CUL3 ATG3 ACTL6A TAF2 PAK1IP1 ARPC4 TRAPPC2L	6.23e-06	454	75	8	33226137
Pubmed	Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.	GABRA1 GABRA2 GABRA3	7.68e-06	18	75	3	19078961
Pubmed	GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.	GABRA1 GABRA2 GABRA3	7.68e-06	18	75	3	18985723
Pubmed	Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.	GABRA1 GABRA2 GABRA3	1.25e-05	21	75	3	25708312
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	BCLAF1 DOCK7 RAI14 ACTL6A TADA2A YWHAG ARPC4 DDX1	1.36e-05	506	75	8	30890647
Pubmed	BCLAF1-induced HIF-1α accumulation under normoxia enhances PD-L1 treatment resistances via BCLAF1-CUL3 complex.	CUL3 BCLAF1	1.37e-05	3	75	2	37906282
Pubmed	Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.	DYRK1B DYRK1A	1.37e-05	3	75	2	32640193
Pubmed	Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development.	TSHZ3 TSHZ2	1.37e-05	3	75	2	16631416
Pubmed	Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.	GABRA1 GABRA2	1.37e-05	3	75	2	18063661
Pubmed	Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.	ZNF384 CREBBP	1.37e-05	3	75	2	27903646
Pubmed	PIK3CA mutation occurs in nasopharyngeal carcinoma but does not significantly influence the disease-specific survival.	BRAF RASA1	1.37e-05	3	75	2	19012001
Pubmed	Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.	TSHZ3 TSHZ2	1.37e-05	3	75	2	19745106
Pubmed	DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.	DYRK1B DYRK1A	1.37e-05	3	75	2	30496304
Pubmed	GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.	GABRA1 GABRA2	1.37e-05	3	75	2	18818659
Pubmed	The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels.	GABRA2 GABRA3	1.37e-05	3	75	2	27128218
Pubmed	GABAA receptor subunits in the human amygdala and hippocampus: Immunohistochemical distribution of 7 subunits.	GABRA1 GABRA3	1.37e-05	3	75	2	29023704
Pubmed	Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptors.	GABRA1 GABRA2	1.37e-05	3	75	2	15254090
Pubmed	DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.	DYRK1B DYRK1A	1.37e-05	3	75	2	21777625
Pubmed	Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas.	BRAF RASA1	1.37e-05	3	75	2	20702649
Pubmed	Candidate genes for alcohol dependence: A genetic association study from India.	GABRA1 GABRA2	1.37e-05	3	75	2	28361821
Pubmed	Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.	GABRA1 GABRA3	1.37e-05	3	75	2	34433078
Pubmed	Gene expression meta-analysis reveals the down-regulation of three GABA receptor subunits in the superior temporal gyrus of patients with schizophrenia.	GABRA1 GABRA2	1.37e-05	3	75	2	32376074
Pubmed	Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.	TSHZ3 TSHZ2	1.37e-05	3	75	2	14973285
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	LAMA4 GABRA1 GABRA3	1.44e-05	22	75	3	35245678
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CUL3 PTPN14 DSG1 BCLAF1 DOCK7 AP1M1 RAI14 ACTL6A PAK1IP1 YWHAG ARPC4 DDX1	1.50e-05	1257	75	12	36526897
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FSIP2 PTPN14 BRAF DYRK1B DOCK7 DYRK1A AP1M1 RAI14 YWHAG DDX1	1.59e-05	861	75	10	36931259
Pubmed	Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression.	CUL3 SNX6	2.75e-05	4	75	2	34510437
Pubmed	Association study between GABA receptor genes and anxiety spectrum disorders.	GABRA2 GABRA3	2.75e-05	4	75	2	19842164
Pubmed	Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice.	GABRA1 GABRA2	2.75e-05	4	75	2	36277219
Pubmed	The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2.	DYRK1B DYRK1A	2.75e-05	4	75	2	27307198
Pubmed	Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.	DYRK1B DYRK1A	2.75e-05	4	75	2	35165364
Pubmed	Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.	DYRK1B DYRK1A	2.75e-05	4	75	2	14593110
Pubmed	Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons.	GABRA1 GABRA2	2.75e-05	4	75	2	14715953
Pubmed	Degradation of AMPK by a cancer-specific ubiquitin ligase.	MAGEA3 MAGEA6	2.75e-05	4	75	2	25679763
Pubmed	Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex.	GABRA1 GABRA3	2.75e-05	4	75	2	20692323
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DSG1 BCLAF1 ADGRB2 DOCK7 PYGB AP1M1 ZDBF2 SLC30A1 YWHAG GABRA1 GABRA2	3.19e-05	1139	75	11	36417873
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZNF384 BCLAF1 DYRK1B DYRK1A ZDBF2 ACTL6A YWHAG DDX1	3.74e-05	583	75	8	29844126
Pubmed	Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.	DSG1 BCLAF1 DOCK7 RAI14 ARPC4 DDX1	3.89e-05	289	75	6	37132043
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	DOCK1 BRAF DOCK7 YWHAG	4.24e-05	89	75	4	27034005
Pubmed	The Rab5 effector FERRY links early endosomes with mRNA localization.	PPP1R21 TBCK	4.57e-05	5	75	2	37267905
Pubmed	Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors.	TADA2A CREBBP	4.57e-05	5	75	2	9649342
Pubmed	Cloning and analysis of MAGE-1-related genes.	MAGEA3 MAGEA6	4.57e-05	5	75	2	8037761
Pubmed	cAMP-response element binding protein (CREB) positively regulates mouse adiponectin gene expression in 3T3-L1 adipocytes.	ATG3 CREBBP	4.57e-05	5	75	2	19932681
Pubmed	γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.	GABRA1 GABRA2	4.57e-05	5	75	2	27129275
Interaction	GPRASP2 interactions	CUL3 TSHZ3 CALCR PIH1D2 PYGB AP1M1 YWHAG	4.40e-07	126	75	7	int:GPRASP2
Interaction	GLCCI1 interactions	CUL3 DYRK1B DYRK1A YWHAG	1.48e-06	23	75	4	int:GLCCI1
Interaction	KIF24 interactions	DYRK1B DYRK1A PYGB AP1M1	8.49e-06	35	75	4	int:KIF24
Interaction	FAM117A interactions	DYRK1B DYRK1A YWHAG	1.75e-05	14	75	3	int:FAM117A
Interaction	PPP1R3F interactions	DYRK1B DYRK1A PYGB	2.18e-05	15	75	3	int:PPP1R3F
Interaction	CDK2 interactions	ZBTB20 BRAF DSG1 BCLAF1 DYRK1B DOCK7 RAI14 ACTL6A CINP CREBBP YWHAG DDX1	3.00e-05	783	75	12	int:CDK2
Interaction	FBXW7 interactions	LIG4 BRAF CCDC47 BCLAF1 DOCK7 DYRK1A AP1M1 RAI14 ACTL6A TADA2A CINP ELP3 FMNL2 YWHAG DDX1	3.45e-05	1215	75	15	int:FBXW7
Interaction	PDLIM7 interactions	CUL3 PTPN14 DYRK1A RAI14 TADA2A ARPC4 TRAPPC2L	5.68e-05	264	75	7	int:PDLIM7
Interaction	RFX7 interactions	DYRK1B DYRK1A YWHAG	6.27e-05	21	75	3	int:RFX7
Interaction	LYN interactions	PTPN14 PDE8A RASA1 DSG1 TBCK DOCK7 RAI14 TADA2A SLC30A1 FMNL2 CREBBP	6.84e-05	720	75	11	int:LYN
Interaction	JUP interactions	PTPN14 BRAF RASA1 DSG1 TSHZ2 PTPRQ FMNL2 CREBBP YWHAG	7.72e-05	485	75	9	int:JUP
Interaction	ATG3 interactions	CUL3 ATG3 ACTL6A TAF2 PAK1IP1 CREBBP TRAPPC2L	8.59e-05	282	75	7	int:ATG3
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRA1 GABRA2 GABRA3	2.23e-05	19	53	3	563
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	RLF ZNF384 TSHZ3 ZNF276 ZBTB20 TSHZ2 ZNF862 ZBTB47 ZNF121	2.16e-04	718	53	9	28
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX6 SNX32	5.46e-04	12	53	2	1290
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 TSHZ2	8.64e-04	15	53	2	529
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	ELP3 CREBBP	1.11e-03	17	53	2	486
GeneFamily	Phosphodiesterases	PDE8A PDE8B	2.23e-03	24	53	2	681
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX6 SNX32	3.25e-03	29	53	2	754
GeneFamily	MAGE family	MAGEA3 MAGEA6	6.12e-03	40	53	2	1136
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB20 ZBTB47 KBTBD2	7.12e-03	134	53	3	861
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RLF ZBTB20 BRAF BCLAF1 DDHD1 DYRK1A	7.79e-07	188	75	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	ZBTB20 BRAF RASA1 DDHD1 GOLGA8A	8.01e-06	162	75	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, Lineage and Cell Type	LGMN PDE8B ZNF862 MED12L ZDBF2	1.33e-05	180	75	5	be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 PTPN14 ZBTB20 EML6 STPG2	1.69e-05	189	75	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ZBTB20 PDE8A BRAF RASA1 FMNL2	1.87e-05	193	75	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	B4GALNT4 TSHZ2 LAMA4 RAI14 MAB21L1	1.87e-05	193	75	5	cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	B4GALNT4 TSHZ2 LAMA4 RAI14 MAB21L1	1.87e-05	193	75	5	e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	B4GALNT4 TSHZ2 LAMA4 RAI14 MAB21L1	1.87e-05	193	75	5	6ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell	Sepsis-ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, condition lineage and cell class	LGMN PDE8B ZNF862 MED12L ZDBF2	2.16e-05	199	75	5	90ddd686b8f39c6f6134b9b048396cebcf8d0448
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 ZBTB20 STXBP5 DYRK1A FMNL2	2.16e-05	199	75	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Drug	Zolpidem	GABRA1 GABRA2 GABRA3	3.30e-08	3	74	3	DB00425
Drug	Flumazenil	GABRA1 GABRA2 GABRA3	1.32e-07	4	74	3	DB01205
Drug	Eszopiclone	GABRA1 GABRA2 GABRA3	3.28e-07	5	74	3	DB00402
Drug	Zopiclone	GABRA1 GABRA2 GABRA3	3.28e-07	5	74	3	DB01198
Drug	Lorazepam	GABRA1 GABRA2 GABRA3	3.28e-07	5	74	3	ctd:D008140
Drug	Meprobamate	GABRA1 GABRA2 GABRA3	6.55e-07	6	74	3	DB00371
Drug	Quazepam	GABRA1 GABRA2 GABRA3	1.14e-06	7	74	3	DB01589
Drug	Adinazolam	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	DB00546
Drug	Fludiazepam	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	DB01567
Drug	Clotiazepam	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	DB01559
Drug	Cinolazepam	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	DB01594
Drug	Prazepam	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	DB01588
Drug	Estazolam	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	DB01215
Drug	Halazepam	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	DB00801
Drug	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	GABRA1 GABRA2 GABRA3	1.82e-06	8	74	3	ctd:C091518
Drug	tiotidine	GABRA1 GABRA2 GABRA3	2.73e-06	9	74	3	ctd:C023990
Drug	Ethchlorvynol	GABRA1 GABRA2 GABRA3	2.73e-06	9	74	3	DB00189
Drug	Diazepam	GABRA1 GABRA2 GABRA3	2.73e-06	9	74	3	DB00829
Drug	Secobarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00418
Drug	Chlordiazepoxide	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00475
Drug	Metharbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00463
Drug	Pentobarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00312
Drug	Talbutal	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00306
Drug	Clobazam	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00349
Drug	Butalbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00241
Drug	Butabarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00237
Drug	Bromazepam	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01558
Drug	Barbituric acid derivative	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01496
Drug	Barbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01483
Drug	Hexobarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01355
Drug	Aprobarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01352
Drug	Amobarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01351
Drug	Heptabarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01354
Drug	Butethal	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01353
Drug	Clonazepam	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB01068
Drug	Methylphenobarbital	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00849
Drug	Oxazepam	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00842
Drug	Primidone	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00794
Drug	Midazolam	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00683
Drug	Flurazepam	GABRA1 GABRA2 GABRA3	3.89e-06	10	74	3	DB00690
Drug	Thiopental	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB00599
Drug	Alprazolam	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB00404
Drug	Temazepam	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB00231
Drug	Nitrazepam	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB01595
Drug	Lorazepam	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB00186
Drug	Phenobarbital	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB01174
Drug	Triazolam	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB00897
Drug	Clorazepate	GABRA1 GABRA2 GABRA3	5.34e-06	11	74	3	DB00628
Drug	lithium acetoacetate	CALCR IDI2	1.04e-05	2	74	2	CID002724246
Drug	dihydroxyaflavinine	GABRA1 GABRA2 GABRA3	2.17e-05	17	74	3	CID000156857
Drug	triazolam	CYP2B6 GABRA1 GABRA2 GABRA3	2.87e-05	54	74	4	CID000005556
Drug	E 4021	PDE8A PDE8B	3.12e-05	3	74	2	ctd:C091517
Drug	chlordiazepoxide	DOCK1 ZNF384 GABRA1 GABRA2 GABRA3	3.52e-05	114	74	5	CID000002712
Drug	propofol	LGMN CYP2B6 PYGB GABRA1 GABRA2 GABRA3	3.72e-05	191	74	6	CID000004943
Drug	flunitrazepam	LGMN GABRA1 GABRA2 GABRA3	4.09e-05	59	74	4	CID000003380
Drug	Flunitrazepam	GABRA1 GABRA2 GABRA3	4.20e-05	21	74	3	ctd:D005445
Drug	5 beta-pregnanediol	CYP2B6 GABRA1 GABRA2 GABRA3	4.37e-05	60	74	4	CID000012547
Drug	phenobarbital quinidine	CYP2B6 GABRA1 GABRA3	4.85e-05	22	74	3	ctd:C033457
Drug	etizolam	CYP2B6 GABRA1 GABRA2	4.85e-05	22	74	3	CID000003307
Drug	gamma-Aminobutyric Acid	CALCR GABRA1 GABRA2 GABRA3	4.97e-05	62	74	4	ctd:D005680
Drug	tert-butylbicyclo-2-benzoate	GABRA1 GABRA2	6.23e-05	4	74	2	ctd:C046308
Drug	etizolam	GABRA2 GABRA3	6.23e-05	4	74	2	ctd:C044610
Drug	methohexital	GABRA1 GABRA2 GABRA3	6.35e-05	24	74	3	CID000009034
Drug	Testosterone Propionate	ZNF276 TSHZ2 GABRA1 GABRA2	7.15e-05	68	74	4	ctd:D043343
Drug	enflurane	LGMN GABRA1 GABRA2 GABRA3	7.15e-05	68	74	4	CID000003226
Drug	etomidate	LGMN GABRA1 GABRA2 GABRA3	8.47e-05	71	74	4	CID000036339
Drug	mephobarbital	CYP2B6 GABRA1 GABRA2	1.02e-04	28	74	3	CID000008271
Drug	Quinidine barbiturate	GABRA1 GABRA2	1.04e-04	5	74	2	DB01346
Drug	tert-butylbicyclophosphorothionate	GABRA1 GABRA2	1.04e-04	5	74	2	ctd:C037476
Drug	alphaxalone	GABRA1 GABRA2	1.04e-04	5	74	2	ctd:C006477
Drug	clotiazepam	CYP2B6 GABRA1 GABRA2	1.13e-04	29	74	3	CID000002811
Drug	tofisopam	CYP2B6 GABRA1 GABRA2	1.13e-04	29	74	3	CID000005502
Drug	3-isothujone	GABRA1 GABRA2 GABRA3	1.26e-04	30	74	3	CID000011027
Drug	lindane	DOCK1 CYP2B6 GABRA1 GABRA2 GABRA3	1.47e-04	154	74	5	CID000000727
Drug	clonazepam	ZNF384 GABRA1 GABRA2 GABRA3	1.48e-04	82	74	4	CID000002802
Drug	Flunitrazepam	GABRA2 GABRA3	1.55e-04	6	74	2	DB01544
Drug	isoborneol	CYP2B6 GABRA1	1.55e-04	6	74	2	ctd:C022871
Drug	2,2-dimethyl-3-hydroxybutyric acid	LIG4 PYGB	1.55e-04	6	74	2	CID000152984
Drug	CGS 8216	GABRA1 GABRA2 GABRA3	1.68e-04	33	74	3	CID000104916
Drug	AC1L2FYN	GABRA1 GABRA2 GABRA3	1.68e-04	33	74	3	CID000071333
Drug	temazepam	CYP2B6 GABRA1 GABRA2	1.83e-04	34	74	3	CID000005391
Drug	meprobamate	CUL3 PYGB GABRA1 GABRA2	1.95e-04	88	74	4	CID000004064
Drug	endosulfan	CYP2B6 GABRA1 GABRA2 GABRA3	1.95e-04	88	74	4	CID000003224
Drug	flurazepam	GABRA1 GABRA2 GABRA3	2.00e-04	35	74	3	CID000003393
Drug	secobarbital	GABRA1 GABRA2 GABRA3	2.37e-04	37	74	3	CID000005193
Drug	DMCM	GABRA1 GABRA2 GABRA3	2.56e-04	38	74	3	CID000104999
Drug	zaleplon	GABRA1 GABRA2 GABRA3	2.77e-04	39	74	3	CID000005719
Drug	Flurothyl	SLC30A1 GABRA1	2.88e-04	8	74	2	ctd:D005481
Drug	Methoxyflurane	CYP2B6 GABRA2	2.88e-04	8	74	2	ctd:D008733
Drug	Gabrene	GABRA1 GABRA2 GABRA3	2.99e-04	40	74	3	CID005361323
Drug	zopiclone	CINP GABRA1 GABRA2	2.99e-04	40	74	3	CID000005735
Drug	gaboxadol	GABRA1 GABRA2 GABRA3	3.21e-04	41	74	3	CID000003448
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	PDE8A RASA1 DYRK1A RAI14 CREBBP	3.27e-04	183	74	5	7498_DN
Drug	5 beta-alphaxalone	GABRA1 GABRA2 GABRA3	3.45e-04	42	74	3	CID000068930
Drug	zolpidem	GABRA1 GABRA2 GABRA3	3.70e-04	43	74	3	CID000005732
Drug	sevoflurane	LGMN GABRA1 GABRA2 GABRA3	3.83e-04	105	74	4	CID000005206
Drug	lorazepam	GABRA1 GABRA2 GABRA3	3.97e-04	44	74	3	CID000003958
Drug	Ro 5-4864	ZNF384 GABRA1 GABRA2	3.97e-04	44	74	3	CID000001688
Drug	endrine	CYP2B6 GABRA1 GABRA2 GABRA3	3.98e-04	106	74	4	CID000003048
Drug	midazolam	CYP2B6 GABRA1 GABRA2 GABRA3	4.12e-04	107	74	4	CID000004192
Disease	Intellectual Disability	CCDC47 MED12L ACTL6A TAF2 YWHAG MAB21L1 GABRA2	1.10e-04	447	72	7	C3714756
Disease	alpha wave measurement, electroencephalogram measurement	METTL21C DNAH1	2.61e-04	10	72	2	EFO_0004357, EFO_0006870
Disease	Small cell carcinoma of lung	BCLAF1 ZDBF2 CREBBP	3.16e-04	54	72	3	C0149925
Disease	Global developmental delay	CCDC47 ACTL6A MAB21L1 GABRA2	3.20e-04	133	72	4	C0557874
Disease	Down syndrome (implicated_via_orthology)	DYRK1B DYRK1A	6.04e-04	15	72	2	DOID:14250 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	DYRK1B DYRK1A	6.89e-04	16	72	2	DOID:0050888 (implicated_via_orthology)
Disease	Noonan-Like Syndrome With Loose Anagen Hair	BRAF RASA1	9.77e-04	19	72	2	C3501846
Disease	Costello syndrome (disorder)	BRAF RASA1	9.77e-04	19	72	2	C0587248
Disease	Noonan syndrome-like disorder with loose anagen hair	BRAF RASA1	9.77e-04	19	72	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	BRAF RASA1	9.77e-04	19	72	2	C1275081
Disease	LEOPARD Syndrome	BRAF RASA1	1.31e-03	22	72	2	C0175704
Disease	Down syndrome (is_marker_for)	DYRK1A ARPC4	1.31e-03	22	72	2	DOID:14250 (is_marker_for)
Disease	colorectal health	DOCK1 LIG4 DSG1 STPG2	1.50e-03	201	72	4	EFO_0008460
Disease	Noonan Syndrome	BRAF RASA1	1.57e-03	24	72	2	C0028326
Disease	Sezary Syndrome	BRAF CREBBP	1.98e-03	27	72	2	C0036920
Disease	myeloid white cell count	SNX32 STXBP5 EML6 MED12L DYRK1A RAI14 TADA2A FMNL2	2.00e-03	937	72	8	EFO_0007988
Disease	Pigmented Basal Cell Carcinoma	PTPN14 RASA1	2.13e-03	28	72	2	C1368275
Disease	Carcinoma, Basal Cell	PTPN14 RASA1	2.28e-03	29	72	2	C4721806

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKAYSEAHEISKEHM	YWHAG	151	P61981
FEKVMHTRKRHSELY	ADGRB2	1471	O60241
SLYHHLHIIETKFEM	BRAF	536	P15056
DTYLLHMEKEKSNAH	CYP2B6	266	P20813
HEAESHMYLKAVKAT	CALCR	331	P30988
AILDHTYKMHVKSEA	ACTL6A	101	O96019
TYKMHVKSEASLHPV	ACTL6A	106	O96019
HSHSRIEYMIKAKSQ	AP1M1	286	Q9BXS5
LYATMEKHKEVFFVI	CREBBP	1621	Q92793
NKHDTEMKYYIVHLK	DYRK1A	211	Q13627
DTEMKYYIVHLKRHF	DYRK1B	166	Q9Y463
HMYEDISQDHVKKTV	ATG3	231	Q9NT62
LFTEHVAEKHIYSLM	CACUL1	251	Q86Y37
VTAEYIHKAEHEKLM	RAI14	671	Q9P0K7
YMKATATQFVHHALK	RASA1	801	P20936
HYSKDHDVKMEIFSP	MED12L	646	Q86YW9
TSYVKVLHHMVKISG	MAGEA3	281	P43357
TSYVKVLHHMVKISG	MAGEA6	281	P43360
HEASFLSALYMHAKK	FSIP2	1631	Q5CZC0
EYTVMTAHFHLKRKI	GABRA2	236	P47869
KMVHFLTHYADKIES	CCDC47	316	Q96A33
HSFDVKKLSEKIMHF	DDX1	411	Q92499
LATEMTKHFEHVNKF	PDE8A	666	O60658
ATEMTKHFEHVNKFV	PDE8B	726	O95263
KTAVMKELYSFLHHQ	ENDOU	236	P21128
SAKRMVEHKFTAVYH	KBTBD2	151	Q8IY47
EYVVMTTHFHLKRKI	GABRA3	261	P34903
EYVVMTTHFHLKRKI	GABRA1	236	P14867
LHGFHDVMKDISKHY	PPP1R21	431	Q6ZMI0
EFHHSIMSQYKLKAS	DSG1	356	Q02413
KVYSFKIHEHETDTI	PTPRQ	1316	Q9UMZ3
VYHHYFLDKLLTTMV	METTL21C	196	Q5VZV1
RAMHKYHFVAKAVEP	DNAH1	3041	Q9P2D7
EDIVFMTIYHHKAKS	IDI2	126	Q9BXS1
HYAHLIKTFGKMRTD	DOCK1	946	Q14185
VKSMVHHLYFNDKLE	DOCK7	1016	Q96N67
IEHIEKDMKHQSFYI	LIG4	256	P49917
EFKTHHEMKEYSGFA	BCLAF1	776	Q9NYF8
AYTMVLHKHGEKLYT	CUL3	61	Q13618
LKEETEFHSTLYHMV	DNAI7	666	Q6TDU7
EYTMHDHNTLLKEFI	FMNL2	916	Q96PY5
FHLAKDSGFKVVAHM	ELP3	271	Q9H9T3
VSFHHRKEMISDIKF	EML6	1076	Q6ZMW3
VALFLLTFMYKHEHD	DDHD1	876	Q8NEL9
YHEISIIYHNDKKMI	LAMA4	1136	Q16363
HLPYTAKAMESHKDE	MEMO1	136	Q9Y316
HMKHSLRYFEEESKD	GOLGA8A	171	A7E2F4
LKFHYMVHTSLDVVD	TRAPPC2L	26	Q9UL33
EYKKHQSDHTYEIMT	TADA2A	51	O75478
NYHMKTLVSYECEKH	MAB21L1	271	Q13394
VETVYTHDMRKKTFH	TAF2	221	Q6P1X5
QYHHKKTFSDATMLI	PTPN14	691	Q15678
SFSKHAHEIMLKYKD	STXBP5	1131	Q5T5C0
LYTDESALKMDHVAH	B4GALNT4	281	Q76KP1
FHTEQMYKHKLVDFV	ARPC4	121	P59998
PTTHFYEVSHKLLEM	CINP	141	Q9BW66
TYVAHVDLALHKEDM	SPG11	231	Q96JI7
KMPAYELKIVHDHSE	PIH1D2	231	Q8WWB5
TFYSKSEMQIHSKSH	ZNF384	236	Q8TF68
AVFYTFNKLKHHLME	RLF	1416	Q13129
YDVHKSYEMSQVKHK	STPG2	356	Q8N412
SSMFDVHVKRIHEYK	PYGB	561	P11216
YHMTKHKAETELDFA	ZNF276	541	Q8N554
HTKEHMYLENKSVFE	ZDBF2	941	Q9HCK1
VAKHTAEFAAHLVKM	TBCK	851	Q8TEA7
DETIHIYDMKKKIEH	PAK1IP1	61	Q9NWT1
SLQDLSVHMIKTKHY	TSHZ2	286	Q9NRE2
KQYFDEHMKTHTGEK	ZBTB47	616	Q9UFB7
SLQDLSVHMIKTKHY	TSHZ3	286	Q63HK5
AEYLAIFKKTVAMHE	SNX6	131	Q9UNH7
SLKDYLIKHMVTHTG	ZBTB20	616	Q9HC78
FKVETLKYHEVSKAH	ZNF862	511	O60290
HAVSVKMHTVEKPYE	ZNF121	131	P58317
YMEVAKTIKDVFHNH	SLC30A1	396	Q9Y6M5
EYLAIFKKTVAMHEV	SNX32	126	Q86XE0
LHVKDLNETIHYMYK	LGMN	161	Q99538