Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	beta-catenin binding	PSEN1 TRPC4 KDM6B SHROOM2 AR NUMB MED12 CDH15	1.33e-05	120	180	8	GO:0008013
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DENND4A MYO9B ARHGEF5 IQSEC2 ARHGEF12 DENND1A TIAM2 SH3BP4 ARFGEF3 TBC1D10B TBC1D4 ARHGAP31 SGSM2 FGD1 RIMS1 RASAL2	1.50e-05	507	180	16	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DENND4A MYO9B ARHGEF5 IQSEC2 ARHGEF12 DENND1A TIAM2 SH3BP4 ARFGEF3 TBC1D10B TBC1D4 ARHGAP31 SGSM2 FGD1 RIMS1 RASAL2	1.50e-05	507	180	16	GO:0030695
GeneOntologyBiologicalProcess	limb development	ZNF219 B4GALNT1 PSEN1 MAP3K20 RUNX2 FREM2 C2CD3 ZNRF3 FGFR2 CTNNB1	2.47e-05	224	177	10	GO:0060173
GeneOntologyBiologicalProcess	appendage development	ZNF219 B4GALNT1 PSEN1 MAP3K20 RUNX2 FREM2 C2CD3 ZNRF3 FGFR2 CTNNB1	2.47e-05	224	177	10	GO:0048736
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	SPRY2 DENND4A MYO9B ARHGEF5 IQSEC2 ARHGEF12 PRAG1 DENND1A TIAM2 ARFGEF3 ARHGAP31 FGD1	3.22e-05	333	177	12	GO:0051056
GeneOntologyCellularComponent	cell cortex	PSEN1 MYO9B TRPC4 IQSEC2 MYRIP SPIRE1 SHROOM2 WASH6P RIMS1 FGFR2 CTNNB1 PARD3	9.40e-05	371	180	12	GO:0005938
GeneOntologyCellularComponent	lamellipodium	CARMIL2 MYO9B CARMIL3 TIAM2 WASH6P ARHGAP31 FGD1 SCRIB CTNNB1	1.77e-04	230	180	9	GO:0030027
GeneOntologyCellularComponent	Scrib-APC-beta-catenin complex	SCRIB CTNNB1	2.20e-04	3	180	2	GO:0034750
GeneOntologyCellularComponent	anchoring junction	MAGI1 KIF23 CARMIL2 ARHGEF5 TRPC4 ADGRB1 ATAT1 SHROOM2 PRAG1 UBA1 ARHGAP31 SVIL SORBS3 NUMB PRKCH SCRIB CTNNB1 PARD3 TNS1 CDH15	2.96e-04	976	180	20	GO:0070161
Domain	ZnF_C2HC	FAM90A14 FAM90A1 ZNF34 FAM90A18 FAM90A9 FAM90A8	1.08e-05	55	171	6	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A1 ZNF34 FAM90A18 FAM90A9 FAM90A8	1.08e-05	55	171	6	IPR001878
Pathway	PID_HES_HEY_PATHWAY	RUNX2 AR MAML2 SPEN GAA	3.77e-05	48	112	5	M288
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SPRY2 ZNF48 MYO9B SPEG KMT5C SPIRE1 PAPLN IRS1 SFI1 EDC4 FBXL19 KDM6B PRAG1 ZNF865 DENND1A ABCA7 AHDC1 RNF43 REXO1 TIAM2 SH3BP4 TAOK2 C2CD3 MAP1S ZNRF3 SGSM2 KANK3 MCM3AP SORBS3 FGFR2 ZNF579 SPEN MED12 SOWAHB PKN3	2.29e-17	1105	187	35	35748872
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A1 FAM90A17 FAM90A19 FAM90A23 FAM90A18 FAM90A9 FAM90A8 FAM90A16	5.87e-15	25	187	9	17684299
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAGI1 DENND4A KIF23 CARMIL2 ARHGEF5 IQSEC2 MAP3K20 SPIRE1 IRS1 GIGYF1 EDC4 ATAT1 PRAG1 DENND1A FAM53C SH3BP4 ARFGEF3 TBC1D10B C2CD3 TBC1D4 PRRC2C STARD9 SVIL ANKRD17 NUMB SCRIB PARD3 RASAL2	2.64e-14	861	187	28	36931259
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A19 FAM90A23 FAM90A9 FAM90A8 FAM90A16	2.65e-11	23	187	7	18602769
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	MAGI1 KIF23 ARHGEF5 MAP3K20 SPIRE1 APLP2 IRS1 PRAG1 SH3BP4 PARD3	2.20e-10	102	187	10	15778465
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TLK2 IRF2BP2 KIF23 USP24 FAM53C REXO1 MYO3A TBC1D10B UBA1 TBC1D4 MAP1S SVIL SORBS3 ANKRD17 RIMS1 SCRIB ZNF579 PARD3 SPEN UNC5D	8.43e-09	774	187	20	15302935
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	IRF2BP2 GIGYF1 C2CD3 FBN1 ARHGAP31 MCM3AP SVIL LZTS2 SPEN RASAL2	6.76e-08	184	187	10	32908313
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	KIF23 USP24 MAP3K20 GIGYF1 ADAR SH3BP4 UBA1 TBC1D4 SSH3 SORBS3 NUMB SCRIB ZNF579 SPEN JPT2	1.09e-07	503	187	15	16964243
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MAGI1 CDC42BPG RTEL1 UVSSA MYRIP SPIRE1 KATNAL1 ATAT1 SHROOM2 DENND1A AHDC1 AR BRWD3 DNAH14 HNRNPL SH3BP4 ARFGEF3 TBC1D4 SGSM2 ANKRD17 NUMB RIMS1 LZTS2 PARD3 NFAT5 CDH15	1.31e-07	1489	187	26	28611215
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A1 FAM90A17 KANK3 FAM90A19 FAM90A23 SMPD1 FAM90A9 FAM90A8	2.86e-07	164	187	9	22967998
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF219 P3H3 GIGYF1 FAM53C ABCA7 RNF43 BRWD3 SNIP1 RSBN1 TBC1D10B ZNRF3 CBY2 MCM3AP ANKRD17 TRAF3IP3 SCRIB ZNF579 LZTS2 PARD3 UNC5D CDH15	7.16e-07	1116	187	21	31753913
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TLK2 MAGI1 KIF23 ZNF219 TRPC4 IQSEC2 ARHGEF12 EDC4 TAOK2 UBA1 PRRC2C SVIL ANKRD17 RIMS1 SCRIB CTNNB1 PARD3 TNS1 RASAL2	1.25e-06	963	187	19	28671696
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	DENND4A KIF23 MAP3K20 IRS1 SHROOM2 SH3BP4 TBC1D4 SVIL PARD3 RASAL2	1.36e-06	255	187	10	15324660
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	DENND4A KIF23 MAP3K20 ARHGEF12 ZNF593 CCDC88B ARFGEF3 SNIP1 MAP1S PRRC2C SPEN	4.62e-06	361	187	11	26167880
Pubmed	Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.	SCRIB CTNNB1 PARD3	5.27e-06	7	187	3	28369449
Pubmed	A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.	RNF43 ZNRF3 CTNNB1	5.27e-06	7	187	3	30692207
Pubmed	The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis.	NUMB FGFR2 CTNNB1 PARD3	5.49e-06	22	187	4	19923290
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TRIM25 ZNF48 MAP3K20 PUSL1 ARHGEF12 ETV6 SPIRE1 APLP2 EDC4 ZNF593 DENND1A AHDC1 TAOK2 SNIP1 RSBN1 BYSL ANKRD17 NUMB ZNF579 LZTS2 PARD3 SPEN MED12	6.26e-06	1497	187	23	31527615
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	SPRY2 ADGRB1 GPRIN3 SH3BP4 TBC1D10B ARHGAP31 NUMB SCRIB CTNNB1 LZTS2 RASAL2	6.96e-06	377	187	11	38117590
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	DENND4A KIF23 SHROOM2 FAM53C TBC1D4 PARD3	7.84e-06	87	187	6	17979178
Pubmed	NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.	RNF43 ZNRF3 CTNNB1	8.40e-06	8	187	3	34079124
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TLK2 MAGI1 CCHCR1 DENND4A IQSEC2 SPIRE1 APLP2 GIGYF1 FBXL19 DENND1A FAM53C USP21 SH3BP4 EFHC2 UBA1 TBC1D4 NUMB CTNNB1 PARD3 PKN3 RASAL2	9.81e-06	1321	187	21	27173435
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SPEG ARHGEF12 ARFGEF3 RSBN1 PRRC2C STARD9 SGSM2 MCM3AP SCRIB SPEN NFAT5	1.42e-05	407	187	11	12693553
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	DENND4A ARHGEF12 EDC4 ARFGEF3 TBC1D4 SCRIB LZTS2 RASAL2	1.89e-05	209	187	8	36779422
Pubmed	JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.	RUNX2 KDM6B CTNNB1	2.45e-05	11	187	3	25587042
Pubmed	RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.	RNF43 ZNRF3	2.88e-05	2	187	2	27661107
Pubmed	CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.	CCHCR1 EDC4	2.88e-05	2	187	2	24858563
Pubmed	Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase.	TYR TH	2.88e-05	2	187	2	10212311
Pubmed	Linking beta-catenin to androgen-signaling pathway.	AR CTNNB1	2.88e-05	2	187	2	11792709
Pubmed	KIF23, under regulation by androgen receptor, contributes to nasopharyngeal carcinoma deterioration by activating the Wnt/β-catenin signaling pathway.	KIF23 AR	2.88e-05	2	187	2	37010644
Pubmed	ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.	RNF43 ZNRF3	2.88e-05	2	187	2	34129813
Pubmed	The prognostic significance of androgen receptor and β-catenin immunohistochemical expression in urothelial carcinoma with and without detrusor muscle invasion from an Egyptian institution.	AR CTNNB1	2.88e-05	2	187	2	30509050
Pubmed	ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress.	ADAR FGFR2	2.88e-05	2	187	2	30573948
Pubmed	Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor.	AR TH	2.88e-05	2	187	2	16356647
Pubmed	Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.	KDM6B CTNNB1	2.88e-05	2	187	2	23856522
Pubmed	IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.	TRIM25 ADAR	2.88e-05	2	187	2	35935998
Pubmed	E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors.	RNF43 ZNRF3	2.88e-05	2	187	2	38969364
Pubmed	A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms.	THSD4 PAPLN	2.88e-05	2	187	2	19734141
Pubmed	Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.	PSEN1 SPEG	2.88e-05	2	187	2	10962005
Pubmed	Sprouty2 correlates with favorable prognosis of gastric adenocarcinoma via suppressing FGFR2-induced ERK phosphorylation and cancer progression.	SPRY2 FGFR2	2.88e-05	2	187	2	28002800
Pubmed	Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape.	TYR FGFR2	2.88e-05	2	187	2	3181757
Pubmed	ZNRF3 is downregulated in papillary thyroid carcinoma and suppresses the proliferation and invasion of papillary thyroid cancer cells.	ZNRF3 CTNNB1	2.88e-05	2	187	2	27448298
Pubmed	Short-term application of dexamethasone on stem cells derived from human gingiva reduces the expression of RUNX2 and β-catenin.	RUNX2 CTNNB1	2.88e-05	2	187	2	28459354
Pubmed	Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells.	AR CTNNB1	2.88e-05	2	187	2	11916967
Pubmed	Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1.	MAGI1 ADGRB1	2.88e-05	2	187	2	9647739
Pubmed	ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation.	THSD4 FBN1	2.88e-05	2	187	2	19940141
Pubmed	Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer.	PSEN1 MAML2	2.88e-05	2	187	2	30055028
Pubmed	IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina.	IQSEC2 ARHGEF12	2.88e-05	2	187	2	19811534
Pubmed	Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients.	IRS1 CTNNB1	2.88e-05	2	187	2	29749571
Pubmed	Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.	NUMB PARD3	2.88e-05	2	187	2	17609107
Pubmed	Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin.	CTNNB1 CDH15	2.88e-05	2	187	2	9545347
Pubmed	ADAMTSL6β protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.	THSD4 FBN1	2.88e-05	2	187	2	21880733
Pubmed	Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT.	RUNX2 CTNNB1	2.88e-05	2	187	2	32535615
Pubmed	Direct association of presenilin-1 with beta-catenin.	PSEN1 CTNNB1	2.88e-05	2	187	2	9738936
Pubmed	Mutual transactivational repression of Runx2 and the androgen receptor by an impairment of their normal compartmentalization.	RUNX2 AR	2.88e-05	2	187	2	17627815
Pubmed	Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.	AR CTNNB1	2.88e-05	2	187	2	10987273
Pubmed	Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling.	SPRY2 FGFR2	2.88e-05	2	187	2	30160357
Pubmed	Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis.	PSEN1 CTNNB1	2.88e-05	2	187	2	12297048
Pubmed	Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.	TYR TH	2.88e-05	2	187	2	16447258
Pubmed	P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation.	RUNX2 FGFR2	2.88e-05	2	187	2	15389579
Pubmed	Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.	PSEN1 CTNNB1	2.88e-05	2	187	2	9852041
Pubmed	RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.	RNF43 ZNRF3	2.88e-05	2	187	2	35039505
Pubmed	Insulin receptor substrate 1 modulates the transcriptional activity and the stability of androgen receptor in breast cancer cells.	IRS1 AR	2.88e-05	2	187	2	18521741
Pubmed	Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/β-catenin pathway.	KIF23 CTNNB1	2.88e-05	2	187	2	37162618
Pubmed	Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA.	RUNX2 AR	2.88e-05	2	187	2	19389811
Pubmed	M-cadherin-inhibited phosphorylation of ß-catenin augments differentiation of mouse myoblasts.	CTNNB1 CDH15	2.88e-05	2	187	2	23138569
Pubmed	PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.	TIAM2 PARD3	2.88e-05	2	187	2	15723051
Pubmed	Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology.	RUNX2 FGFR2 CTNNB1	3.25e-05	12	187	3	19389359
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	MAGI1 DENND4A MAP3K20 GIGYF1 DENND1A TBC1D4 MAP1S CTNNB1 LZTS2 PARD3 RASAL2	3.29e-05	446	187	11	24255178
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KIF23 USP24 EDC4 ADAR UBA1 PRRC2C NUMB SCRIB LZTS2 PARD3 SPEN MED12	4.65e-05	549	187	12	38280479
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CDC42BPG SPRY2 ZNF775 IQSEC2 ADGRB1 IRS1 FAM186B DNAH14 HNRNPL FREM2 TBC1D4 FBXO10 MCM3AP SCRIB	4.93e-05	736	187	14	29676528
Pubmed	Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1.	SPRY2 RUNX2 FGFR2	5.33e-05	14	187	3	22395741
Pubmed	Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung.	SPRY2 FGFR2 CTNNB1	5.33e-05	14	187	3	16989802
Pubmed	Epicardial spindle orientation controls cell entry into the myocardium.	NUMB CTNNB1 PARD3	5.33e-05	14	187	3	20643355
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	USP24 APLP2 EDC4 RTN2 RNF43 TAOK2 ARFGEF3 TMUB1 TBC1D10B ZNRF3 BYSL ANKRD17 SCRIB CTNNB1 HSPA14 GAA	5.48e-05	942	187	16	31073040
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CDC42BPG DENND4A ARHGEF5 PAPLN GIGYF1 SH3BP4 WASH6P FREM2 TBC1D10B PRRC2C ANKRD17 SCRIB RASAL2	5.56e-05	650	187	13	38777146
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CACNA1B CARMIL3 USP24 ARHGEF12 GPRIN3 HNRNPL WASH6P TBC1D10B PRRC2C PARD3 NFAT5	5.79e-05	475	187	11	31040226
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	MAGI1 TRIM25 ARHGEF12 TBC1D10B SSH3 SVIL NUMB SCRIB CTNNB1 LZTS2 PARD3 JPT2	6.12e-05	565	187	12	25468996
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	MAGI1 CARMIL2 JPH2 APLP2 ATP10D TBC1D10B ARHGAP31 NUMB SCRIB CTNNB1 PARD3 RASAL2	6.54e-05	569	187	12	30639242
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SHROOM2 SCRIB PARD3	6.64e-05	15	187	3	34835087
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	SPRY2 NECAB2 FAM131C NPAS3 AR TAOK2 EFHC2 CBY2 SORBS3 LZTS2	7.01e-05	402	187	10	24722188
Pubmed	14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.	SPEG GIGYF1 TH TBC1D4	7.72e-05	42	187	4	23444366
Pubmed	Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.	SCRIB CTNNB1 PARD3	8.14e-05	16	187	3	32460029
Pubmed	Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis.	AR SCRIB CTNNB1 PARD3	8.48e-05	43	187	4	32294451
Pubmed	Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.	TLK2 GIGYF1 FAM53C CTNNB1	8.48e-05	43	187	4	36950384
Pubmed	MiR-138-5p targets RUNX2 to inhibit osteogenic differentiation of aortic valve interstitial cells via Wnt/β-catenin signaling pathway.	RUNX2 CTNNB1	8.60e-05	3	187	2	35109802
Pubmed	Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.	PSEN1 APLP2	8.60e-05	3	187	2	20693289
Pubmed	Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.	PSEN1 APLP2	8.60e-05	3	187	2	29018038
Pubmed	Tyrosinase: a developmentally specific major determinant of peripheral dopamine.	TYR TH	8.60e-05	3	187	2	12832289
Pubmed	Tumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain.	IRS1 SMPD1	8.60e-05	3	187	2	15721320
Pubmed	Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization.	AR CTNNB1	8.60e-05	3	187	2	26636186
Pubmed	Androgen signaling is a confounding factor for β-catenin-mediated prostate tumorigenesis.	AR CTNNB1	8.60e-05	3	187	2	25893287
Pubmed	Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.	SCRIB CTNNB1	8.60e-05	3	187	2	16611247
Pubmed	Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071.	PSEN1 CTNNB1	8.60e-05	3	187	2	10092585
Pubmed	Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer.	RUNX2 FGFR2	8.60e-05	3	187	2	26551078
Pubmed	Numb confers to inhibit epithelial mesenchymal transition via β-catenin/Lin28 signaling pathway in breast cancer.	NUMB CTNNB1	8.60e-05	3	187	2	31095937
Pubmed	Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance.	MAGI1 SCRIB	8.60e-05	3	187	2	21489588
Pubmed	Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis.	AR CTNNB1	8.60e-05	3	187	2	12944908
Pubmed	ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma.	ZNRF3 CTNNB1	8.60e-05	3	187	2	23504200
Pubmed	A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4.	AR CTNNB1	8.60e-05	3	187	2	12799378
Interaction	TOP3B interactions	SPRY2 KIF23 TRIM25 ZNF48 RTEL1 MYO9B SPEG KMT5C SPIRE1 PAPLN IRS1 SFI1 EDC4 FBXL19 KDM6B PRAG1 ZNF865 DENND1A ABCA7 AHDC1 RNF43 REXO1 TIAM2 SH3BP4 TAOK2 C2CD3 MAP1S ZNRF3 SGSM2 KANK3 MCM3AP SVIL SORBS3 BYSL ANKRD17 FGFR2 ZNF579 SPEN MED12 SOWAHB PKN3	1.58e-11	1470	175	41	int:TOP3B
Interaction	YWHAG interactions	MAGI1 BNIP5 DENND4A KIF23 CARMIL2 ARHGEF5 SPEG IQSEC2 USP24 MAP3K20 SPIRE1 IRS1 GIGYF1 EDC4 ATAT1 SHROOM2 PRAG1 DENND1A FAM53C USP21 SH3BP4 TAOK2 SNIP1 TBC1D10B UBA1 C2CD3 TBC1D4 PRRC2C STARD9 SVIL ANKRD17 NUMB SCRIB LZTS2 PARD3 RASAL2	1.42e-10	1248	175	36	int:YWHAG
Interaction	YWHAZ interactions	TLK2 CDC42BPG BNIP5 DENND4A KIF23 TRIM25 CARMIL2 PDE7A ARHGEF5 SPEG IQSEC2 MAP3K20 SPIRE1 IRS1 GIGYF1 ATAT1 DENND1A FAM53C AR HNRNPL USP21 SH3BP4 TH MYO3A UBA1 TBC1D4 ANKRD34B STARD9 SSH3 SVIL ANKRD17 NUMB SCRIB CTNNB1 PARD3 TNS1 RASAL2	1.64e-10	1319	175	37	int:YWHAZ
Interaction	YWHAH interactions	MAGI1 CDC42BPG DENND4A KIF23 CARMIL2 ARHGEF5 SPEG IQSEC2 MAP3K20 SPIRE1 IRS1 GIGYF1 EDC4 ATAT1 PRAG1 DENND1A FAM53C USP21 SH3BP4 ARFGEF3 TBC1D10B UBA1 C2CD3 TBC1D4 PRRC2C STARD9 SVIL ANKRD17 NUMB RIMS1 SCRIB PARD3 RASAL2	3.70e-10	1102	175	33	int:YWHAH
Interaction	PLEKHA7 interactions	MAGI1 CCHCR1 GIGYF1 DENND1A FAM53C RNF43 USP21 CTNNB1 LZTS2 PARD3 SOWAHB RASAL2	5.33e-10	119	175	12	int:PLEKHA7
Interaction	SH3PXD2A interactions	MAGI1 DENND4A TRIM25 GIGYF1 DENND1A FAM53C HNRNPL USP21 SH3BP4 SVIL FGD1 RASAL2	1.25e-09	128	175	12	int:SH3PXD2A
Interaction	MAGI1 interactions	MAGI1 DENND4A ADGRB1 GIGYF1 DENND1A FAM53C HNRNPL USP21 SH3BP4 CTNNB1 PARD3 RASAL2	6.11e-09	147	175	12	int:MAGI1
Interaction	SFN interactions	MAGI1 DENND4A KIF23 TRIM25 ARHGEF5 MAP3K20 SPIRE1 APLP2 IRS1 CHST1 GIGYF1 EDC4 DENND1A FAM53C SH3BP4 TBC1D4 PRRC2C SVIL ANKRD17 NUMB SCRIB CTNNB1 PARD3 RASAL2	7.77e-09	692	175	24	int:SFN
Interaction	YWHAB interactions	MAGI1 DENND4A KIF23 TRIM25 CARMIL2 PDE7A ARHGEF5 SPEG IQSEC2 MAP3K20 SPIRE1 IRS1 GIGYF1 ATAT1 DENND1A FAM53C RNF43 SH3BP4 TH TBC1D10B TBC1D4 STARD9 SVIL ANKRD17 NUMB FGFR2 SCRIB PARD3 RASAL2	1.40e-08	1014	175	29	int:YWHAB
Interaction	AGAP1 interactions	MAGI1 TRIM25 GIGYF1 DENND1A FAM53C HNRNPL USP21 SH3BP4 LZTS2 RASAL2	7.54e-08	117	175	10	int:AGAP1
Interaction	FAM53C interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 SH3BP4 SORBS3 RASAL2	1.31e-07	68	175	8	int:FAM53C
Interaction	SH3BP4 interactions	MAGI1 TRIM25 ARHGEF12 GIGYF1 DENND1A FAM53C HNRNPL USP21 SH3BP4 PARD3	2.04e-07	130	175	10	int:SH3BP4
Interaction	SRSF12 interactions	MAGI1 DENND4A KIF23 GIGYF1 DENND1A FAM53C USP21 SH3BP4 SNIP1 RASAL2	2.04e-07	130	175	10	int:SRSF12
Interaction	DENND1A interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C HNRNPL USP21 SH3BP4 RASAL2	2.40e-07	101	175	9	int:DENND1A
Interaction	EIF4E2 interactions	MAGI1 SPRY2 DENND4A NECAB2 GIGYF1 DENND1A FAM53C USP21 SH3BP4 CBY2 ANKRD17 LZTS2 RASAL2	2.48e-07	246	175	13	int:EIF4E2
Interaction	ANKRD34A interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	3.63e-07	53	175	7	int:ANKRD34A
Interaction	SIPA1L1 interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C USP21 SH3BP4 CTNNB1 LZTS2 PARD3 RASAL2	3.65e-07	174	175	11	int:SIPA1L1
Interaction	YWHAE interactions	BNIP5 DENND4A KIF23 TRIM25 CARMIL2 PDE7A ARHGEF5 IQSEC2 MAP3K20 SPIRE1 IRS1 GIGYF1 ATAT1 SHROOM2 PRAG1 DENND1A FAM53C RNF43 HNRNPL USP21 SH3BP4 TAOK2 UBA1 TBC1D4 SVIL ANKRD17 NUMB CTNNB1 PARD3 RASAL2	3.99e-07	1256	175	30	int:YWHAE
Interaction	YWHAQ interactions	DENND4A KIF23 TRIM25 CARMIL2 ARHGEF5 SPEG IQSEC2 MAP3K20 SPIRE1 IRS1 GIGYF1 ATAT1 DENND1A FAM53C RNF43 AR HNRNPL SH3BP4 TH TBC1D4 STARD9 SVIL ANKRD17 NUMB SCRIB CTNNB1 PARD3 RASAL2	4.01e-07	1118	175	28	int:YWHAQ
Interaction	PHLDB2 interactions	MAGI1 KIF23 GIGYF1 DENND1A FAM53C USP21 CTNNB1 LZTS2 PARD3 RASAL2	4.98e-07	143	175	10	int:PHLDB2
Interaction	CBY1 interactions	MAGI1 DENND4A TRIM25 SPIRE1 GIGYF1 DENND1A FAM53C USP21 SH3BP4 CTNNB1 RASAL2	5.72e-07	182	175	11	int:CBY1
Interaction	PPM1H interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C HNRNPL USP21 UBA1 RASAL2	1.29e-06	123	175	9	int:PPM1H
Interaction	AFDN interactions	MAGI1 TRIM25 GIGYF1 DENND1A FAM53C USP21 TAOK2 SORBS3 NUMB SCRIB CTNNB1 LZTS2 PARD3 RASAL2	1.34e-06	333	175	14	int:AFDN
Interaction	DCLK1 interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C USP21 SH3BP4 EFHC2 RASAL2	1.68e-06	127	175	9	int:DCLK1
Interaction	FAM110B interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	1.85e-06	67	175	7	int:FAM110B
Interaction	MAST3 interactions	MAGI1 DENND4A TRIM25 USP24 GIGYF1 DENND1A FAM53C USP21 RASAL2	1.92e-06	129	175	9	int:MAST3
Interaction	TESK2 interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	2.06e-06	97	175	8	int:TESK2
Interaction	ZNF638 interactions	MAGI1 DENND4A GIGYF1 ADAR DENND1A FAM53C RNF43 HNRNPL USP21 SH3BP4 SCRIB RASAL2	3.13e-06	261	175	12	int:ZNF638
Interaction	DGCR6 interactions	SPRY2 NECAB2 REXO1 EFHC2 TBC1D4 CBY2 LZTS2	3.32e-06	73	175	7	int:DGCR6
Interaction	GIGYF1 interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C RNF43 USP21 SH3BP4 LZTS2 RASAL2	3.47e-06	177	175	10	int:GIGYF1
Interaction	FLOT1 interactions	CA9 MAGI1 KIF23 ARHGEF12 ETV6 GPRIN3 FAM90A1 AR SVIL SORBS3 NUMB SCRIB CTNNB1 LZTS2 PARD3 RASAL2	4.15e-06	475	175	16	int:FLOT1
Interaction	KIF13B interactions	MAGI1 DENND4A KIF23 GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	4.24e-06	142	175	9	int:KIF13B
Interaction	SYDE1 interactions	MAGI1 APLP2 GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	5.31e-06	110	175	8	int:SYDE1
Interaction	MTCL2 interactions	KIF23 NECAB2 ZNF219 TRIM25 JPH2 HNRNPL EFHC2 LZTS2	6.93e-06	114	175	8	int:MTCL2
Interaction	RTKN interactions	MAGI1 DENND4A ARHGEF12 GIGYF1 DENND1A FAM53C USP21 RASAL2	7.39e-06	115	175	8	int:RTKN
Interaction	DVL2 interactions	ELOA2 ZBTB48 RTEL1 IRS1 RUNX2 FAM90A1 ADAR RNF43 SH3BP4 TAOK2 SNIP1 ZNRF3 SORBS3 BYSL NUMB CTNNB1 PARD3	7.58e-06	557	175	17	int:DVL2
Interaction	HDAC4 interactions	CACNA1B MAGI1 DENND4A CARMIL3 USP24 GPRIN3 GIGYF1 RUNX2 DENND1A FAM53C AR HNRNPL USP21 EFHC2 TBC1D10B MAP1S PRRC2C CTNNB1 PARD3 RASAL2	7.66e-06	744	175	20	int:HDAC4
Interaction	SRGAP2 interactions	MAGI1 DENND4A GIGYF1 KDM6B DENND1A FAM53C HNRNPL USP21 SH3BP4 RASAL2	8.96e-06	197	175	10	int:SRGAP2
Interaction	RASAL2 interactions	MAGI1 TRIM25 GIGYF1 DENND1A FAM53C RNF43 USP21 PARD3 RASAL2	1.01e-05	158	175	9	int:RASAL2
Interaction	VASP interactions	MAGI1 IRF2BP2 TRIM25 FRS3 ARHGEF12 ARFGEF3 TBC1D10B SVIL NUMB CTNNB1 LZTS2 PARD3	1.05e-05	294	175	12	int:VASP
Interaction	AIRIM interactions	CCHCR1 NECAB2 GIGYF1 KATNAL1 CCDC88B HNRNPL CBY2 SORBS3 LZTS2	1.06e-05	159	175	9	int:AIRIM
Interaction	ZBTB21 interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C AR USP21 SH3BP4 RASAL2	1.18e-05	161	175	9	int:ZBTB21
Interaction	PARD3 interactions	MAGI1 TRIM25 RNF43 TIAM2 HNRNPL SH3BP4 NUMB SCRIB CTNNB1 LZTS2 PARD3 RASAL2	1.20e-05	298	175	12	int:PARD3
Interaction	LRFN1 interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	1.29e-05	124	175	8	int:LRFN1
Interaction	KIFC3 interactions	CCHCR1 KIF23 NECAB2 GIGYF1 FAM90A1 CBY2 MCM3AP SVIL SORBS3 BYSL LZTS2	1.33e-05	252	175	11	int:KIFC3
Interaction	PIPSL interactions	KIF23 TRIM25 KMT5C PUSL1 SFI1 ATAT1 ZNF865 DNAH14 TAOK2 FBXO10 VWA5A	1.33e-05	252	175	11	int:PIPSL
Interaction	TBC1D25 interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 SH3BP4	1.34e-05	60	175	6	int:TBC1D25
Interaction	CETN1 interactions	CCHCR1 SFI1 DNAH14 SH3BP4 SGSM2 MCM3AP	1.77e-05	63	175	6	int:CETN1
Interaction	RCOR3 interactions	CCHCR1 NECAB2 FOXQ1 AR HNRNPL PRDM1 EFHC2 CBY2 LZTS2	2.00e-05	172	175	9	int:RCOR3
Interaction	KSR1 interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	2.03e-05	132	175	8	int:KSR1
Interaction	CDC25B interactions	MAGI1 GIGYF1 DENND1A FAM53C AR USP21 SH3BP4 RASAL2	2.27e-05	134	175	8	int:CDC25B
Interaction	UBXN6 interactions	CDC42BPG TRIM25 RTEL1 ARHGEF5 ARHGEF12 AR UBA1 TBC1D4 MAP1S MCM3AP GPAT2 HSPA14	2.84e-05	325	175	12	int:UBXN6
Interaction	CSNK1A1 interactions	KIF23 TRIM25 IRS1 GIGYF1 RNF43 AR HNRNPL SH3BP4 ANKRD17 CTNNB1 LZTS2 MED12 RASAL2	2.99e-05	381	175	13	int:CSNK1A1
Interaction	ZMIZ1 interactions	TRIM25 AR HNRNPL TBC1D4 CTNNB1	3.85e-05	44	175	5	int:ZMIZ1
Interaction	THBS3 interactions	PDE7A RTEL1 IQSEC2 RUNX2 SH3BP4 C5orf34	4.47e-05	74	175	6	int:THBS3
Interaction	DEPDC1B interactions	MAGI1 ARHGEF12 GIGYF1 ADAR DENND1A FAM53C USP21 CTNNB1 PARD3	4.74e-05	192	175	9	int:DEPDC1B
Interaction	PARD3B interactions	TRIM25 HNRNPL CTNNB1 PARD3 GAA	4.79e-05	46	175	5	int:PARD3B
Interaction	CGN interactions	MAGI1 DENND4A TRIM25 GIGYF1 DENND1A AR LZTS2 RASAL2	5.58e-05	152	175	8	int:CGN
Interaction	GSK3A interactions	DENND4A TRIM25 ARHGEF12 C11orf87 EDC4 AHDC1 AR ARFGEF3 TBC1D4 PRKCH SCRIB CTNNB1 LZTS2 RASAL2	5.63e-05	464	175	14	int:GSK3A
Interaction	KIAA1217 interactions	RNF43 AR HNRNPL SORBS3 CTNNB1 LZTS2 PARD3	6.58e-05	115	175	7	int:KIAA1217
Interaction	NADK interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 RASAL2	6.95e-05	80	175	6	int:NADK
Interaction	USP21 interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 SH3BP4 CTNNB1 RASAL2	8.37e-05	161	175	8	int:USP21
Interaction	KIF1C interactions	MAGI1 TRIM25 GIGYF1 DENND1A FAM53C USP21 RASAL2	8.61e-05	120	175	7	int:KIF1C
Interaction	KCTD3 interactions	MAGI1 DENND4A TRIM25 GIGYF1 DENND1A FAM53C USP21 RASAL2	9.52e-05	164	175	8	int:KCTD3
Interaction	ALMS1 interactions	THSD4 KIF23 TRIM25 ARHGEF12 ETV6 RNF43 TFR2 LZTS2	9.52e-05	164	175	8	int:ALMS1
Interaction	FRS3 interactions	SPRY2 FRS3 SLC22A18AS CBY2 NUMB TGM7 TNS1	9.56e-05	122	175	7	int:FRS3
Interaction	PBX1 interactions	FOXQ1 MAP3K20 ZNF593 FAM90A1 HNRNPL VWA5A	9.76e-05	85	175	6	int:PBX1
Interaction	CCDC57 interactions	SFI1 GIGYF1 FAM90A1 GPKOW HNRNPL EFHC2 CBY2 SORBS3	9.93e-05	165	175	8	int:CCDC57
Interaction	TLE3 interactions	IRF2BP2 FOXQ1 ETV6 TPRX2 AHDC1 AR HNRNPL PRDM1 TBC1D4 MCM3AP CTNNB1 SPEN	1.15e-04	376	175	12	int:TLE3
Interaction	RUNX1T1 interactions	SPRY2 NECAB2 EFHC2 CBY2 SORBS3 LZTS2 SPEN	1.23e-04	127	175	7	int:RUNX1T1
Interaction	SH3RF3 interactions	MAGI1 TRIM25 GIGYF1 DENND1A HNRNPL	1.24e-04	56	175	5	int:SH3RF3
Interaction	GIPC2 interactions	TRIM25 ARHGEF12 SH3BP4 LZTS2	1.26e-04	30	175	4	int:GIPC2
Interaction	TJP1 interactions	MAGI1 KIF23 TRPC4 RNF43 AR HNRNPL TAOK2 CTNNB1 LZTS2 PARD3 SOWAHB	1.33e-04	325	175	11	int:TJP1
Interaction	CTDSPL interactions	GPRIN3 HNRNPL TBC1D10B TBC1D4 NUMB FGFR2	1.51e-04	92	175	6	int:CTDSPL
Interaction	PPP1R13B interactions	CCHCR1 TRIM25 FAM90A1 RNF43 CBY2 CTNNB1 LZTS2 PARD3	1.55e-04	176	175	8	int:PPP1R13B
Interaction	CDK16 interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 SH3BP4 RASAL2	1.56e-04	132	175	7	int:CDK16
Interaction	GRIK2 interactions	TRIM25 GRIK4 HNRNPL CTNNB1	1.63e-04	32	175	4	int:GRIK2
Interaction	KAT6B interactions	ETV6 RUNX2 HNRNPL SNIP1	2.08e-04	34	175	4	int:KAT6B
Interaction	DENND4C interactions	MAGI1 DENND4A GIGYF1 DENND1A FAM53C USP21 RASAL2	2.25e-04	140	175	7	int:DENND4C
Interaction	LATS2 interactions	MAGI1 KIF23 GIGYF1 RNF43 AR HNRNPL CTNNB1 LZTS2 PARD3 RASAL2	2.25e-04	289	175	10	int:LATS2
Interaction	CTNNA1 interactions	CA9 MAGI1 TRIM25 PSEN1 AR NUMB SCRIB CTNNB1 LZTS2 PARD3 CDH15	2.34e-04	347	175	11	int:CTNNA1
Interaction	ZC2HC1C interactions	FAM90A1 CCDC88B CBY2 SORBS3 BYSL LZTS2	2.39e-04	100	175	6	int:ZC2HC1C
Interaction	CCNC interactions	CCHCR1 TRIM25 FBXL19 FAM90A1 TRAF3IP3 LZTS2 SPEN MED12	2.44e-04	188	175	8	int:CCNC
Interaction	TRIML2 interactions	CCHCR1 NECAB2 FAM90A1 CBY2 SPEN	2.53e-04	65	175	5	int:TRIML2
Interaction	INPP5E interactions	MAGI1 DENND4A GIGYF1 DENND1A RASAL2	2.53e-04	65	175	5	int:INPP5E
Interaction	FMR1 interactions	MAGI1 KIF23 NECAB2 ZNF219 IQSEC2 EDC4 ADAR HNRNPL PRRC2C ANKRD17 SCRIB CTNNB1 PARD3 TNS1	2.54e-04	536	175	14	int:FMR1
Interaction	FAM110A interactions	MAGI1 GIGYF1 DENND1A FAM53C USP21 SH3BP4	2.66e-04	102	175	6	int:FAM110A
Interaction	RSPO1 interactions	RNF43 ZNRF3 ZNF579	2.71e-04	15	175	3	int:RSPO1
Interaction	ZNF609 interactions	THSD4 TRIM25 FOXQ1 TPRX2 AR HNRNPL PRDM1	2.91e-04	146	175	7	int:ZNF609
Interaction	FXR1 interactions	SPRY2 KIF23 NECAB2 ZNF219 FOXQ1 EDC4 FAM90A1 AR WASH6P PRRC2C SORBS3 BYSL ANKRD17 SCRIB CTNNB1 LZTS2	2.94e-04	679	175	16	int:FXR1
Interaction	RND1 interactions	FRS3 SH3BP4 UBA1 NUMB SCRIB CTNNB1 PARD3 NFAT5 RASAL2	3.09e-04	246	175	9	int:RND1
Interaction	NFAT5 interactions	TRIM25 HNRNPL TBC1D4 NFAT5	3.22e-04	38	175	4	int:NFAT5
Interaction	WWTR1 interactions	KIF23 TRIM25 USP24 EDC4 RUNX2 ADAR UBA1 PRRC2C NUMB SCRIB LZTS2 PARD3	3.31e-04	422	175	12	int:WWTR1
Interaction	DCAF7 interactions	TRIM25 TPRX2 FBXL19 KDM6B FAM53C AR SVIL NUMB LZTS2 PARD3 SOWAHB	3.86e-04	368	175	11	int:DCAF7
Interaction	CSNK1D interactions	KIF23 TRIM25 HNRNPL SNIP1 BYSL CTNNB1 LZTS2 JPT2 RASAL2	3.90e-04	254	175	9	int:CSNK1D
Interaction	SRCIN1 interactions	HNRNPL TAOK2 SORBS3 CTNNB1	3.93e-04	40	175	4	int:SRCIN1
Interaction	SOCS3 interactions	ETV6 IRS1 RUNX2 AR TFR2 MAP1S	4.00e-04	110	175	6	int:SOCS3
Interaction	FBXO16 interactions	EDC4 HNRNPL CTNNB1	4.00e-04	17	175	3	int:FBXO16
Interaction	C11orf52 interactions	MAGI1 GPRIN3 SH3BP4 TBC1D10B NUMB SCRIB CTNNB1 LZTS2 PARD3 RASAL2	4.03e-04	311	175	10	int:C11orf52
Interaction	TNS1 interactions	FRS3 AR SORBS3 TNS1	4.33e-04	41	175	4	int:TNS1
Cytoband	8p23.1	FAM90A14 PRAG1 FAM90A17 FAM90A19 FAM90A23 FAM90A18 FAM90A9 FAM90A8 FAM90A16	1.62e-08	154	187	9	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 PRAG1 FAM90A17 FAM90A19 FAM90A23 FAM90A18 FAM90A9 FAM90A8 FAM90A16	5.75e-07	234	187	9	chr8p23
GeneFamily	PDZ domain containing	MAGI1 ARHGEF12 SHROOM2 TIAM2 RIMS1 SCRIB PARD3	3.14e-05	152	106	7	1220
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF5 ARHGEF12 TIAM2 FGD1	6.08e-04	66	106	4	722
GeneFamily	ADAMTS like	THSD4 PAPLN	7.01e-04	7	106	2	947
GeneFamily	C2 domain containing protein kinases	PRKCH PKN3	1.49e-03	10	106	2	835
Coexpression	GSE6092_UNSTIM_VS_IFNG_STIM_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_DN	NECAB2 NPY5R CARMIL3 KCP JPH2 SFI1 TIAM2 TFR2 FBN1 GAA	1.14e-06	200	177	10	M6715
Coexpression	HALLMARK_APICAL_JUNCTION	SPEG MAP3K20 IRS1 SHROOM2 SLC30A3 TAOK2 FBN1 SORBS3 CDH15	9.28e-06	200	177	9	M5915
Coexpression	GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_DN	TLK2 USB1 KDM6B CCDC88B FAM53C RSBN1 PRRC2C SPEN	2.13e-05	170	177	8	M6855
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 ACADL DNAH14 ARFGEF3 FREM2 ZNRF3 SORCS2 FGFR2 PARD3 SLC22A31	5.81e-09	191	179	10	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 ACADL RNF43 FREM2 ZNRF3 SORCS2 FGFR2 PARD3 SLC22A31	5.85e-08	183	179	9	6847c1252d6bb105524f812658112517fd351eab
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 ACADL ARFGEF3 FREM2 ZNRF3 SORCS2 FGFR2 PARD3 SLC22A31	8.45e-08	191	179	9	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	MAGI1 ACADL DNAH14 ARFGEF3 FREM2 ZNRF3 FGFR2 PARD3 SLC22A31	8.83e-08	192	179	9	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	THSD4 DENND4A MYO9B ETV6 DENND1A ANKRD17 MAML2 NFAT5 RASAL2	9.23e-08	193	179	9	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACADL SPIRE1 ARFGEF3 FREM2 TBC1D4 ZNRF3 SORCS2 FGFR2 SLC22A31	1.15e-07	198	179	9	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, Lineage and Cell Type	CCHCR1 ZNF775 RUNX2 HSD11B1L AHDC1 RTN2 AR NTAN1	3.62e-07	165	179	8	8728f927502e56f2768b4224e9111939d3d7815a
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF775 PRAG1 RTN2 SNIP1 FBXO10 KANK3 NFAT5 RASAL2	8.61e-07	185	179	8	efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF775 PRAG1 RTN2 SNIP1 FBXO10 KANK3 NFAT5 RASAL2	8.61e-07	185	179	8	642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	THSD4 MAGI1 ACADL DNAH14 ARFGEF3 FREM2 FGFR2 PARD3	9.71e-07	188	179	8	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	THSD4 CACNA1B MAGI1 SPEG MAP3K20 IRS1 PRAG1 RNF43	1.01e-06	189	179	8	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 DNAH14 TBC1D4 FGFR2 MAML2 PARD3 NFAT5 UNC5D	1.09e-06	191	179	8	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAGI1 ACADL PRAG1 DNAH14 FREM2 ZNRF3 FGFR2 SLC22A31	1.09e-06	191	179	8	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	MAGI1 ACADL ARFGEF3 FREM2 ZNRF3 SORCS2 FGFR2 SLC22A31	1.14e-06	192	179	8	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACADL SPIRE1 ARFGEF3 FREM2 ZNRF3 FGFR2 PARD3 SLC22A31	1.18e-06	193	179	8	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACADL SPIRE1 ARFGEF3 FREM2 ZNRF3 FGFR2 PARD3 SLC22A31	1.18e-06	193	179	8	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAGI1 ACADL DNAH14 ARFGEF3 FREM2 FGFR2 PARD3 SLC22A31	1.18e-06	193	179	8	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAGI1 ACADL DNAH14 ARFGEF3 FREM2 FGFR2 PARD3 SLC22A31	1.23e-06	194	179	8	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 ACADL SPIRE1 ARFGEF3 FREM2 SORCS2 PARD3 SLC22A31	1.23e-06	194	179	8	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	COVID-19-kidney-T-cells-1\|kidney / Disease (COVID-19 only), tissue and cell type	IL10RA PDE7A GPRIN3 RUNX2 CCDC88B PRDM1 PRKCH TRAF3IP3	1.38e-06	197	179	8	9bb7faf4ef63cca4d06c60e6c05a9616fdb6b98e
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SPIRE1 ARFGEF3 FREM2 TBC1D4 ZNRF3 SORCS2 FGFR2 SLC22A31	1.43e-06	198	179	8	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THSD4 MAGI1 ACADL DNAH14 ARFGEF3 FREM2 FGFR2 PARD3	1.49e-06	199	179	8	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THSD4 MAGI1 ACADL DNAH14 ARFGEF3 FREM2 FGFR2 PARD3	1.49e-06	199	179	8	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Sepsis-Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, condition lineage and cell class	CCHCR1 ZNF775 RUNX2 HSD11B1L AHDC1 RTN2 USP21 NTAN1	1.49e-06	199	179	8	a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ACADL TRPC4 FAM131C KCP RUNX2 PRDM1 VWA5A PARD3	1.54e-06	200	179	8	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ACADL TRPC4 MAP3K20 FAM131C TH ANKRD34B STARD9	2.45e-06	149	179	7	1e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCell	10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3\|Liver / Manually curated celltypes from each tissue	ZNF219 B4GALNT1 SHROOM2 DNAH14 SH3BP4 EFHC2 SVIL	4.43e-06	163	179	7	7f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FOXQ1 ARHGEF5 KCP PRDM1 KANK3 PRKCH PKN3	4.80e-06	165	179	7	7d319a112b9062efee428bef6f4534d2ce782e04
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	SPRY2 MYRIP RUNX2 DNAH14 EFHC2 VWA5A STARD9	6.31e-06	172	179	7	980e8b9e1ceeb0dec9eb9ef95c139e5ffe99b6e4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPC4 RUNX2 PRDM1 ANKRD34B SVIL PRKCH FGFR2	8.80e-06	181	179	7	af92b8b7f455210dab502ef6964f3a0162180759
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	MAGI1 SPIRE1 ARFGEF3 FREM2 SVIL FGFR2 PARD3	8.80e-06	181	179	7	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	IPF-Epithelial-ATII\|IPF / Disease state, Lineage and Cell class	MAGI1 ACADL ARFGEF3 FREM2 FGFR2 PARD3 SLC22A31	1.01e-05	185	179	7	563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCell	IPF-Epithelial-ATII\|World / Disease state, Lineage and Cell class	MAGI1 ACADL ARFGEF3 FREM2 FGFR2 PARD3 SLC22A31	1.05e-05	186	179	7	6a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	RUNX2 MCM3AP SORBS3 PRKCH TRAF3IP3 GAA	1.05e-05	123	179	6	511b7c20a4a85e49980936d52af7dbca19bb848e
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IL10RA GPRIN3 PRDM1 TBC1D4 NTAN1 TRAF3IP3 FUT7	1.09e-05	187	179	7	9fdfca5b70f585843ef9d810154674a8e561e765
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IL10RA GPRIN3 PRDM1 TBC1D4 NTAN1 TRAF3IP3 FUT7	1.09e-05	187	179	7	a525753a8a908ee1ef0b8f06e68855e4af27bf86
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	MAGI1 ACADL ARFGEF3 FREM2 FGFR2 PARD3 SLC22A31	1.13e-05	188	179	7	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACADL TRPC4 FAM131C ETV6 RUNX2 PRDM1 ANKRD34B	1.13e-05	188	179	7	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SPEG MAP3K20 JPH2 PAPLN IRS1 SORCS2 RIMS1	1.17e-05	189	179	7	b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE7A PAPLN AR MYO3A PARD3 TNS1 UNC5D	1.17e-05	189	179	7	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACADL TRPC4 FAM131C ETV6 RUNX2 PRDM1 FGFR2	1.17e-05	189	179	7	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 MAGI1 TBC1D4 SORCS2 ANKRD17 MAML2 NFAT5	1.17e-05	189	179	7	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THSD4 ARHGEF12 SH3BP4 STARD9 KANK3 PRKCH RASAL2	1.21e-05	190	179	7	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACADL TRPC4 FAM131C RUNX2 AR PRDM1 UNC5D	1.21e-05	190	179	7	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	MAGI1 ACADL DNAH14 FREM2 FGFR2 PARD3 SLC22A31	1.25e-05	191	179	7	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 MAGI1 SPIRE1 SH3BP4 TBC1D4 SORCS2 NFAT5	1.29e-05	192	179	7	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	THSD4 MAGI1 DNAH14 ARFGEF3 FGFR2 PARD3 SLC22A31	1.29e-05	192	179	7	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAGI1 DNAH14 FREM2 ZNRF3 SORCS2 FGFR2 SLC22A31	1.29e-05	192	179	7	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 PDE7A DENND1A SVIL ANKRD17 MAML2 PARD3	1.29e-05	192	179	7	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	THSD4 MAGI1 SPEG MAP3K20 JPH2 PRAG1 MYO3A	1.34e-05	193	179	7	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 TMC7 MYRIP FBN1 ARHGAP31 PRKCH PKN3	1.34e-05	193	179	7	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	SPRY2 MYRIP RUNX2 DNAH14 SH3BP4 EFHC2 VWA5A	1.34e-05	193	179	7	826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF12 APLP2 TAOK2 KANK3 NUMB PRKCH RASAL2	1.43e-05	195	179	7	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FOXQ1 TRPC4 MAP3K20 ARHGEF12 FBN1 SVIL TNS1	1.48e-05	196	179	7	cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THSD4 ARHGEF12 SHROOM2 ARHGAP31 STARD9 KANK3 PRKCH	1.48e-05	196	179	7	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FOXQ1 TRPC4 MAP3K20 ARHGEF12 FBN1 SVIL TNS1	1.48e-05	196	179	7	44e2df1b61e3819eae7e482bef0a733afe852d67
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	IL10RA MYO9B ETV6 APLP2 KDM6B ADAR PRRC2C	1.58e-05	198	179	7	61ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THSD4 MAGI1 ACADL DNAH14 FREM2 FGFR2 PARD3	1.63e-05	199	179	7	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_intermediate\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SPRY2 ZNF219 ACADL AR FREM2 ZNRF3 FGFR2	1.63e-05	199	179	7	debdd7dba774d9ccff7effc3f4c132393d203dfa
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MAGI1 ACADL TRPC4 FAM131C RUNX2 PRDM1 FGFR2	1.68e-05	200	179	7	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPC4 RUNX2 PRDM1 ANKRD34B SVIL PRKCH FGFR2	1.68e-05	200	179	7	8c1d4fffa5abe89ee2ff84fed2dfa97c779bde04
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RA PDE7A GPRIN3 RUNX2 PRDM1 PRKCH TRAF3IP3	1.68e-05	200	179	7	be9a43acc2f926b9433ab3f018b911b03896a924
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPC4 RUNX2 PRDM1 ANKRD34B SVIL PRKCH FGFR2	1.68e-05	200	179	7	1026b4ede4ea61d01ea942164b37a08c8c8234ff
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-Treg\|COVID-19_Mild / Disease, condition lineage and cell class	IL10RA GPRIN3 PRDM1 RSBN1 TBC1D4 TRAF3IP3 FUT7	1.68e-05	200	179	7	c6ae15f7deba26008af5b647855675003bb2ebcd
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RA PDE7A GPRIN3 RUNX2 PRDM1 PRKCH TRAF3IP3	1.68e-05	200	179	7	20ffb3436d08042f77800513e6ddb3bbc38ae6fe
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RA PDE7A GPRIN3 RUNX2 PRDM1 PRKCH TRAF3IP3	1.68e-05	200	179	7	e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RA PDE7A GPRIN3 RUNX2 PRDM1 PRKCH TRAF3IP3	1.68e-05	200	179	7	c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MAGI1 ACADL TRPC4 FAM131C RUNX2 PRDM1 FGFR2	1.68e-05	200	179	7	fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MAGI1 ACADL TRPC4 FAM131C RUNX2 PRDM1 FGFR2	1.68e-05	200	179	7	c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPC4 RUNX2 PRDM1 ANKRD34B SVIL PRKCH FGFR2	1.68e-05	200	179	7	72c9cd872074b60f62685a95eab83c41e609eb6e
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CARMIL3 BRWD3 SLC22A18AS ARHGAP31 BRWD1-AS2 PARD3	3.63e-05	153	179	6	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	THSD4 CACNA1B MAP3K20 IRS1 PRAG1 RNF43	4.19e-05	157	179	6	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ACADL DNAH14 FREM2 SORCS2 FGFR2 SLC22A31	4.50e-05	159	179	6	e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CA9 KIF23 P3H3 IRS1 ZNRF3 HSPA14	4.66e-05	160	179	6	5cd4fbbd2ce671a8377416eff94041a111375dee
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPRY2 PAPLN SHROOM2 PRAG1 SORCS2 MAML2	5.34e-05	164	179	6	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CARMIL2 GPRIN3 RUNX2 PRDM1 PRKCH TRAF3IP3	5.52e-05	165	179	6	8dbd03795fff060cd2e4d5d97348f5b63515e030
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CARMIL2 GPRIN3 RUNX2 PRDM1 PRKCH TRAF3IP3	5.52e-05	165	179	6	5fc5e34cc805df44c020256729256ef761790152
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CARMIL2 GPRIN3 RUNX2 PRDM1 PRKCH TRAF3IP3	5.52e-05	165	179	6	64c7c45383afde1d050934938705e47aa615755f
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PDE7A KATNAL1 NTAN1 SCRIB ZNF579 GPAT2	6.11e-05	168	179	6	8459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRS3 C2CD3 FBXO10 MAP1S FGD1 CFAP157	6.11e-05	168	179	6	b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CARMIL3 FAM131C NPAS3 ANKRD34B PRRC2C GAA	6.31e-05	169	179	6	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCHCR1 BNIP5 GFRA4 FAM83C AR TBC1D4	6.52e-05	170	179	6	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THSD4 MAGI1 ACADL RNF43 FREM2 FGFR2	7.18e-05	173	179	6	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	droplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPRY2 FOXQ1 RNF43 TFR2 TBC1D4 FUT7	7.41e-05	174	179	6	009e88a6c79689a5d88b0af50aa89aa03b33f800
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT1 GPRIN3 ZNF865 PRDM1 PRKCH TRAF3IP3	7.41e-05	174	179	6	6ca9433d398aa3b48ecdc522dd545119e7c77dd4
ToppCell	droplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPRY2 FOXQ1 RNF43 TFR2 TBC1D4 FUT7	7.41e-05	174	179	6	e9e4532a474b4b0938a50ff85c9508aca53cd3ae
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A SPIRE1 HNRNPL PRRC2C NUMB MAML2	7.65e-05	175	179	6	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K20 FAM131C KCP RUNX2 ANKRD34B SVIL	7.90e-05	176	179	6	95d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT1 PDE7A GPRIN3 RNF43 PRDM1 PRKCH	8.15e-05	177	179	6	6d86b2f97426b552dff5ce6ddf0ead1285ed618e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACADL TRPC4 ETV6 RUNX2 PRDM1 FGFR2	8.15e-05	177	179	6	91706bd0d4dda8d98843fb00b898d5aca4d66b64
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT1 PDE7A GPRIN3 RNF43 PRDM1 PRKCH	8.15e-05	177	179	6	d8b1bbc224d062a57a6ad40b4b2af5d6e0fe63b3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 ACADL TBC1D4 BYSL NFAT5 UNC5D	8.40e-05	178	179	6	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MYRIP ARHGAP31 CROCC2 KANK3 PRKCH RASAL2	8.67e-05	179	179	6	8f9e538c822940785130297712b75131812a4603
ToppCell	facs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 TRPC4 MAP3K20 JPH2 C11orf87 FREM2	8.94e-05	180	179	6	0059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCell	facs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 TRPC4 MAP3K20 JPH2 C11orf87 FREM2	8.94e-05	180	179	6	dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACADL TRPC4 ETV6 RUNX2 PRDM1 ANKRD34B	9.21e-05	181	179	6	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD4 SPEG MAP3K20 FAM131C JPH2 IRS1	9.21e-05	181	179	6	25915e2500430a902db37d79a749ce2990b69810
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPC4 IRS1 SHROOM2 MYO3A STARD9 TNS1	9.21e-05	181	179	6	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K20 FAM131C KCP RUNX2 ANKRD34B SVIL	9.21e-05	181	179	6	7704f236831cffe4f2a75d4c461eb88b4177e206
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACADL TRPC4 KCP RUNX2 AR PRDM1	9.49e-05	182	179	6	f00eec1f434d92d44787d3d3343476c98c3de5b4
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A	CA9 ELOA2 IQSEC2 ADGRB1 SFI1 RTN2 AR FBN1 MCM3AP PARD3 SPEN	4.46e-07	200	175	11	2648_UP
Drug	Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; HL60; HT_HG-U133A	PSEN1 USP24 ETV6 ATP10D TAOK2 TBC1D4 C11orf71 PARD3 NFAT5 TNS1	3.25e-06	198	175	10	2560_DN
Drug	Deltaline [6836-11-9]; Up 200; 7.8uM; HL60; HT_HG-U133A	MAGI1 RTEL1 ADGRB1 FRS3 TFR2 TAOK2 SORBS3 FGD1 PRKCH RASAL2	3.25e-06	198	175	10	2171_UP
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	TRIM25 RTEL1 KDM6B RNF43 TAOK2 SLC22A18AS VWA5A FGD1 TNS1	2.01e-05	194	175	9	3354_DN
Drug	Cefoperazone dihydrate; Down 200; 5.8uM; MCF7; HT_HG-U133A	SPRY2 ELOA2 RTEL1 MYO9B TBC1D4 MAP1S VWA5A SORBS3 PARD3	2.09e-05	195	175	9	5424_DN
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A	TRIM25 ZBTB48 MYO9B ARHGEF12 AHDC1 TBC1D10B SGSM2 SSH3 MED12	2.18e-05	196	175	9	4793_DN
Drug	Guanfacine hydrochloride [29110-48-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A	ELOA2 IQSEC2 ETV6 TAOK2 ZNF34 SGSM2 SSH3 SORBS3 RASAL2	2.36e-05	198	175	9	5621_DN
Drug	Fursultiamine Hydrochloride [2105-43-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TRIM25 USB1 RTEL1 MYO9B AHDC1 TAOK2 TBC1D4 MAP1S SORBS3	2.36e-05	198	175	9	7349_DN
Drug	Guanfacine hydrochloride [29110-48-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A	MAGI1 DENND4A USB1 ATP10D TAOK2 VWA5A MCM3AP FGD1 RASAL2	2.36e-05	198	175	9	2634_UP
Drug	Metaraminol bitartrate [33402-03-8]; Up 200; 8.6uM; MCF7; HT_HG-U133A	TRPC4 SFI1 SLC30A3 RTN2 TFR2 TH SSH3 FGD1 TNS1	2.45e-05	199	175	9	2298_UP
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A	TRIM25 MYO9B AHDC1 AR SVIL SORBS3 PRKCH FGFR2 MED12	2.45e-05	199	175	9	7338_DN
Drug	Methamphetamine	MAGI1 CCHCR1 ZNF775 SPEG PUSL1 SFI1 GIGYF1 EDC4 KDM6B GFRA4 AR REXO1 PRDM1 TAOK2 TH UBA1 TBC1D4 PRRC2C KANK3 SVIL CTNNB1 LZTS2 PARD3 NFAT5 TNS1 PKN3	2.65e-05	1401	175	26	ctd:D008694
Disease	Nonorganic psychosis	NPAS3 GRIK4 TYR FGFR2 MED12	5.28e-05	69	172	5	C0349204
Disease	Adrenocortical carcinoma	ZNRF3 CTNNB1 MED12	1.49e-04	18	172	3	C0206686
Disease	non-melanoma skin carcinoma	CCDC88B FAM83C TYR RSBN1 BPIFB4 PARD3 CDH15 SLC22A31	1.73e-04	265	172	8	EFO_0009260
Disease	skin sensitivity to sun	KATNAL1 TYR PARD3	1.76e-04	19	172	3	EFO_0004795
Disease	FG syndrome	FGD1 MED12	2.01e-04	4	172	2	cv:C0220769
Disease	severe acute respiratory syndrome, COVID-19	THSD4 MAGI1 ZNF775 P3H3 MYRIP REXO1 FBXO10 SORCS2 MAML2 PARD3	3.12e-04	447	172	10	EFO_0000694, MONDO_0100096
Disease	Psychotic Disorders	NPAS3 GRIK4 TYR FGFR2 MED12	3.20e-04	101	172	5	C0033975
Disease	cancer	CCHCR1 RTEL1 MYO9B FAM83C TYR FGFR2 PARD3 CDH15 SLC22A31	5.97e-04	400	172	9	MONDO_0004992
Disease	Mental Retardation, X-Linked	IQSEC2 BRWD3 FGD1	6.36e-04	29	172	3	C1136249
Disease	Alzheimer disease	PSEN1 ABCA7	9.24e-04	8	172	2	cv:C0002395
Disease	NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO	SCRIB PARD3	9.24e-04	8	172	2	C3891448
Disease	prostate cancer (implicated_via_orthology)	AR FGFR2 CTNNB1	9.34e-04	33	172	3	DOID:10283 (implicated_via_orthology)
Disease	influenza A severity measurement	PRAG1 MAML2	1.18e-03	9	172	2	EFO_0007743
Disease	interleukin 25 measurement	ARHGEF12 GRIK4	1.18e-03	9	172	2	EFO_0008182
Disease	Nerve Degeneration	PSEN1 APLP2 TH CTNNB1	1.43e-03	83	172	4	C0027746
Disease	Odontome	RUNX2 FGFR2	1.47e-03	10	172	2	C0524730
Disease	decadienedioic acid (C10:2-DC) measurement	PAPLN NUMB	1.47e-03	10	172	2	EFO_0800598
Disease	Tooth Abnormalities	RUNX2 FGFR2	1.47e-03	10	172	2	C0040427
Disease	stomach cancer (is_marker_for)	ADGRB1 ADAR RNF43 FGFR2 CTNNB1	1.50e-03	142	172	5	DOID:10534 (is_marker_for)
Disease	Malignant neoplasm of breast	FOXQ1 TRPC4 SHROOM2 ADAR AR HNRNPL C5orf34 FGFR2 CTNNB1 LZTS2 SPEN TNS1 HSPA14 MED12 RASAL2	1.62e-03	1074	172	15	C0006142
Disease	invasive ductal carcinoma (is_marker_for)	ADGRB1 AR FGD1	1.64e-03	40	172	3	DOID:3008 (is_marker_for)
Disease	gastric adenocarcinoma (is_implicated_in)	RTEL1 RNF43	1.79e-03	11	172	2	DOID:3717 (is_implicated_in)
Disease	nevus count, cutaneous melanoma	FOXQ1 RTEL1 TYR CDH15	2.01e-03	91	172	4	EFO_0000389, EFO_0004632
Disease	autism spectrum disorder (implicated_via_orthology)	KMT5C TRPC4 TAOK2 RIMS1 CTNNB1	2.02e-03	152	172	5	DOID:0060041 (implicated_via_orthology)
Disease	Bipolar Disorder	CACNA1B MAGI1 NPAS3 GRIK4 TH STARD9 SORCS2 RIMS1 FGFR2	2.02e-03	477	172	9	C0005586
Disease	event free survival time, type 1 diabetes mellitus, autoantibody measurement	RSBN1 TH	2.15e-03	12	172	2	EFO_0000482, EFO_0004866, MONDO_0005147
Disease	stomach carcinoma (is_implicated_in)	RNF43 FGFR2	2.15e-03	12	172	2	DOID:5517 (is_implicated_in)
Disease	Craniofacial Abnormalities	SPRY2 RUNX2 FGD1 FGFR2 CTNNB1	2.26e-03	156	172	5	C0376634
Disease	FEV/FEC ratio	THSD4 SPRY2 SPEG MAP3K20 ETV6 RUNX2 FREM2 C5orf34 FBN1 ARHGAP31 CROCC2 SVIL FGFR2 MAML2 PARD3 TNS1	2.30e-03	1228	172	16	EFO_0004713
Disease	Gastric Adenocarcinoma	TLK2 SPEG CTNNB1	2.31e-03	45	172	3	C0278701
Disease	Adenocarcinoma of large intestine	RNF43 ZNRF3 PRKCH CTNNB1	2.44e-03	96	172	4	C1319315
Disease	chronic obstructive pulmonary disease	THSD4 USB1 SPEG MAP3K20 NPAS3 RUNX2 C5orf34 SVIL MAML2 TNS1 SPPL2C	2.45e-03	688	172	11	EFO_0000341
Disease	serum gamma-glutamyl transferase measurement	THSD4 PSEN1 FAM131C FBXL19 GFRA4 SLC30A3 USP21 MAP1S SVIL FGFR2 LZTS2 PARD3 PKN3	2.82e-03	914	172	13	EFO_0004532
Disease	Arthritis, Psoriatic	RUNX2 FBXL19	2.94e-03	14	172	2	C0003872
Disease	developmental disorder of mental health (implicated_via_orthology)	GIGYF1 PARD3 RASAL2	2.95e-03	49	172	3	DOID:0060037 (implicated_via_orthology)
Disease	intraocular pressure measurement	NPAS3 ARHGEF12 GRIK4 RUNX2 TYR EFHC2 FBN1 ZNRF3 TNS1	3.11e-03	509	172	9	EFO_0004695
Disease	ulcerative colitis	CCHCR1 RTEL1 KCP PRDM1 BPIFB4 MAML2 CDH15	3.62e-03	335	172	7	EFO_0000729
Disease	colorectal mucinous adenocarcinoma	FOXQ1 ETV6	3.84e-03	16	172	2	EFO_0009361
Disease	central nervous system disease (implicated_via_orthology)	IRF2BP2 TAOK2	3.84e-03	16	172	2	DOID:331 (implicated_via_orthology)
Disease	Dyskeratosis Congenita	USB1 RTEL1	3.84e-03	16	172	2	C0265965
Disease	platelet crit	RTEL1 MYO9B ARHGEF12 JPH2 KDM6B TFR2 SH3BP4 SVIL NUMB GAA PKN3 CDH15 RASAL2	3.97e-03	952	172	13	EFO_0007985
Disease	clonal hematopoiesis mutation measurement	SH3BP4 TBC1D4 FGFR2	4.09e-03	55	172	3	EFO_0020949
Disease	hepatocellular carcinoma (is_implicated_in)	RNF43 HNRNPL PRDM1 FGFR2 CTNNB1	4.27e-03	181	172	5	DOID:684 (is_implicated_in)
Disease	Multiple congenital anomalies	FGFR2 CTNNB1	4.34e-03	17	172	2	C0000772
Disease	Drug habituation	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C0013170
Disease	Drug abuse	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C0013146
Disease	Prescription Drug Abuse	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C4316881
Disease	Substance-Related Disorders	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C0236969
Disease	Drug Use Disorders	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C0013222
Disease	Drug Dependence	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C1510472
Disease	Substance Dependence	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C0038580
Disease	Substance Use Disorders	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	THSD4 ETV6 TIAM2 PRKCH	4.67e-03	115	172	4	C0029231
Disease	Substance abuse problem	THSD4 ETV6 TIAM2 PRKCH	4.81e-03	116	172	4	C0740858
Disease	Malignant neoplasm of endometrium	FGFR2 CTNNB1	4.86e-03	18	172	2	C0007103
Disease	level of Sphingomyelin (d34:1) in blood serum	USP24 ANKRD17	4.86e-03	18	172	2	OBA_2045175
Disease	Carcinoma in situ of endometrium	FGFR2 CTNNB1	4.86e-03	18	172	2	C0346191
Disease	PROSTATE CANCER, HEREDITARY, 1	MYO9B ATAT1 RNF43	5.22e-03	60	172	3	C4722327
Disease	diet measurement, HOMA-B	MAGI1 NFAT5	5.41e-03	19	172	2	EFO_0004469, EFO_0008111
Disease	emphysema pattern measurement	SVIL SOWAHB	5.41e-03	19	172	2	EFO_0005850
Disease	level of Sphingomyelin (d38:2) in blood serum	KANK3 ANKRD17	5.41e-03	19	172	2	OBA_2045179
Disease	facial asymmetry measurement	NPAS3 FAM53C	5.41e-03	19	172	2	EFO_0009751
Disease	level of Sterol ester (27:1/20:3) in blood serum	USP24 NTAN1	5.41e-03	19	172	2	OBA_2045199
Disease	cutaneous melanoma	FOXQ1 RTEL1 TYR PARD3	5.58e-03	121	172	4	EFO_0000389
Disease	red blood cell density measurement	THSD4 IRF2BP2 DENND4A ZNF219 ETV6 KDM6B TFR2 TBC1D4 ZNRF3 SORCS2 TRAF3IP3 MAML2	5.64e-03	880	172	12	EFO_0007978

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRQHTRPPPQERGSG	BRWD1-AS2	56	P59051
GQAPHPRLARRGTLP	ANKRD34C	336	P0C6C1
PGDTPRQRFRQRHPG	CCDC88B	1411	A6NC98
RDEVPRAQLPTHRPG	CXorf49;	401	A8MYA2
LDQPQARHVSRRPNP	C2orf78	726	A6NCI8
RVLGGHRAPRQLPAA	ACADL	11	P28330
EAAFTIRIRHPPNPR	B4GALNT1	246	Q00973
RLHRRELQPGEIPPG	BPIFB4	146	P59827
RRQQPPQHDGLRPRA	ADGRB1	146	O14514
PQGHPARLHRIVPRL	SMPD1	66	P17405
LAGQPLRHPTRARPR	CARMIL2	1011	Q6F5E8
LPQASDPAVARQHRP	ARHGEF5	776	Q12774
VNPPARPHLENSLRR	FBXO10	906	Q9UK96
PHPTKFQRLVPGREN	BRWD3	596	Q6RI45
PVRPQPQGIHRFREA	SLC22A18AS	46	Q8N1D0
PASLPRDQLRGHPDI	FAM186B	871	Q8IYM0
RRLEPQQPLGHCPLA	AHDC1	346	Q5TGY3
PPSHDLNRAPRVPVQ	ANKRD17	736	O75179
TSRPRQPEHRGVPLQ	HSD11B1L	226	Q7Z5J1
TQRTQDAPHEARPPL	CACNA1B	1941	Q00975
PRQVHIPPNPQDLRL	CFAP157	466	Q5JU67
APNQPRQKIRHPSLG	ATP10D	601	Q9P241
SNAILRAHLPPGPAR	ABCA7	1491	Q8IZY2
QLPPLPELRLRNNGH	CA9	186	Q16790
LGPPRRPSRHDNSAI	ARHGEF12	601	Q9NZN5
QLERHVVRPPPRSPE	FBXL19	396	Q6PCT2
PQRPRILVQLSPHDN	DENND4A	361	Q7Z401
IRQPEGTPLNHFRRI	EDC4	221	Q6P2E9
SPEPPSRRHQRVQDK	P3H3	711	Q8IVL6
GPQRPHSFSEALRRP	CDC42BPG	1476	Q6DT37
SDPPRPHRILQALRR	APLP2	481	Q06481
LENIPPGPLSRRNHA	ANKRD34B	411	A5PLL1
PQPAVRHQGREPLLV	FAM90A23	211	A8MXZ1
RLSPAERAQGPRPHQ	ETV6	211	P41212
RSPHRPILQAGLPAN	FGFR2	251	P21802
PEHRRTARRTPPGQQ	ELOA2	126	Q8IYF1
PANHAPLREQGAIPR	CTNNB1	521	P35222
GLPQPPRESPQLHER	JPH2	461	Q9BR39
HPRPGQERPGVARKE	MAP1S	491	Q66K74
REQRAHNAHLRGPPP	LZTS2	111	Q9BRK4
VPEVRAGPDRRQHPS	MAGI1	1256	Q96QZ7
PREPARAQAPNHRVQ	GIGYF1	791	O75420
VSPVPPLRRQQHLRS	KMT5C	36	Q86Y97
REAPPLSQRPHRTQG	KAAG1	51	Q9UBP8
RPRPQDPQRKALLHI	FAM90A1	106	Q86YD7
VPDPNRPQRLGLHQR	IQSEC2	981	Q5JU85
RLGPRPRSHNKVLNP	JPT2	166	Q9H910
DRTKRQIPHGRAPPD	FREM2	3081	Q5SZK8
SRGDHPPDKRPVRLN	MCM3AP	316	O60318
GSAPPERQEQRHSLP	KDM6B	296	O15054
LRHQTQGRPRPPRTT	CARMIL3	971	Q8ND23
IRRHRITLPPPDEDQ	EFHC2	131	Q5JST6
PQPAVRHQGREPLLV	FAM90A14	211	P0C7W9
PLDRPVPQHVLSRRG	PDE7A	11	Q13946
RRSHLPLAQRPRGQP	FUT7	101	Q11130
RHQRARDPAPTNFPL	FAM157C	326	P0CG43
QVRRPLHPALNQPGG	RASAL2	761	Q9UJF2
PDRHIPLALPRQNST	RASAL2	851	Q9UJF2
IPLIQNGHRRQPPAR	GPKOW	71	Q92917
NPTLVDPTRHLQQRP	MED12	1981	Q93074
HPQADRTLGNREPPV	IL10RA	341	Q13651
REVIQNPGPRHPEAA	AR	31	P10275
PQPAVRHQGREPLLV	FAM90A17	211	P0DV74
APPRVAALVHRQPEN	PRSS38	26	A1L453
IINPIRRHPQRVDPN	IRS1	646	P35568
PQPAVRHQGREPLLV	FAM90A16	211	P0DV73
RPDNLLPGRAESVHP	NFAT5	856	O94916
PQPAVRHQGREPLLV	FAM90A19	211	P0DV76
PHRGNDQGKPRSRLP	RIMS1	956	Q86UR5
DRRRPPSPRIQIQHA	RIMS1	1141	Q86UR5
PQDQINRHLSRPPPD	MAML2	786	Q8IZL2
PQPAVRHQGREPLLV	FAM90A8	211	A6NJQ4
PQRGTAEPFPRLHNL	CBY2	51	Q8NA61
QTQQRPLCPRERPRH	CEFIP	1216	Q711Q0
RRPRGKEGISQHPEP	BNIP5	121	P0C671
SSPERAVNPHLPRQG	C2CD3	2131	Q4AC94
RGFQHPSPRGRSLPQ	ADAR	106	P55265
LVHPSAQRPRRLPAG	GFRA4	166	Q9GZZ7
RRPLRSPQRATSPHQ	CROCC2	371	H7BZ55
LPRSRPLLQFHRGAP	FAM83C	446	Q9BQN1
AQPHPCRRGFIPNIR	FBN1	226	P35555
RNSHPAELDLPRAPQ	FRS3	121	O43559
PRGQDSPLLQRPQHL	ARFGEF3	2056	Q5TH69
AGIPQPPSPELQHRR	FAM131C	231	Q96AQ9
PPSPELQHRRRLPGA	FAM131C	236	Q96AQ9
QRILGHIQAPPRPFL	GPAT2	146	Q6NUI2
PLVQPPGHQDVSERR	CCHCR1	36	Q8TD31
PHLPGTQDPLRRVRD	DNAH14	91	Q0VDD8
RDAQAHPGRPRAVPT	GAA	66	P10253
KRSPRDLHQPNTIPG	MAP3K20	731	Q9NYL2
TVLDQHLRPPARRPG	ATAT1	16	Q5SQI0
DRRPITVHFGQVRPP	DENND1A	486	Q8TEH3
NKRQRQPPLLGDHPA	HNRNPL	301	P14866
PRAPVRNPRVEHTLR	KANK3	121	Q6NY19
RQPPHRRPCLPTAQA	FAM90A20P	361	A6NIJ5
QDSIHPRRRRAAVPP	GRIK4	856	Q16099
GEPQAASPRHRPALL	GPRIN3	26	Q6ZVF9
PVSAHPLEQPERIRQ	C5orf34	41	Q96MH7
PQPAVRHQGREPLLV	FAM90A5P	211	A8MXJ8
LHLRPPSRGNSPKEQ	FAM53C	76	Q9NYF3
GRPRQDHLPLLPPSN	SLC22A31	531	A6NKX4
PLRRDAPQGRLHPQP	CDH15	686	P55291
LNRQSPNPRRGHAVP	IRF2BP2	171	Q7Z5L9
RLQPHPQLSPEIRRE	BYSL	406	Q13895
PQPAVRHQGREPLLV	FAM90A24P	211	P0C7X0
ALQAASVRRPGPHLP	FOXQ1	381	Q9C009
TVQRAPRLNHPPEQI	PARD3	401	Q8TEW0
TLNGDIPFHRPRPRI	PARD3	901	Q8TEW0
EQLPPAHPLRSRVTR	PKN3	241	Q6P5Z2
PLPARRQHTLQAPGS	HSPA14	421	Q0VDF9
FQPDQNAPPIRLRHR	KIF23	796	Q02241
IPRRHAPIEQLARQG	NUMB	261	P49757
GLRAARPTSPPQDHR	NUTM2D	636	Q5VT03
AHLDVQRRSGRPPFP	PUSL1	76	Q8N0Z8
AAAAVPRLRPPHDNR	RUNX2	86	Q13950
ERLAVPPVLTHRAPQ	RTEL1	1151	Q9NZ71
PRPQGRSVSEPRDQH	RTN2	86	O75298
RRSRQHPGPLPPTNA	RSBN1	116	Q5VWQ0
EHRAPPQIRRPNREV	KATNAL1	106	Q9BW62
APGEKRRIAHIPNPR	REXO1	726	Q8N1G1
RRIAHIPNPRLAAAP	REXO1	731	Q8N1G1
RPHFLLEPAQSQRPQ	SFI1	1011	A8K8P3
AAQLRQLRDHLPPPS	UVSSA	461	Q2YD98
QERLSPEVAPPAHRR	SNIP1	31	Q8TAD8
RRSLGHPEPLSNGRP	PSEN1	41	P49768
PVTNGLHAEPPVRRD	SH3BP4	221	Q9P0V3
PRRGSLERANPPITH	SVIL	996	O95425
PQPEGPPSLRCHRRQ	KCP	1046	Q6ZWJ8
VLPAPERPSQENHSR	NPY5R	296	Q15761
PQPAVRHEGREPLLV	FAM90A12P	211	A8MX19
PQPAVRHQGREPLLV	FAM90A9	211	A6NNJ1
PQPAVRHQGREPLLV	FAM90A13P	211	P0C7W8
QSLEPHPEGPQRLRS	FGD1	121	P98174
HAQLTRVPRSPPAGR	SORCS2	61	Q96PQ0
PRAEHIPSGPLRQRE	PRRC2C	1226	Q9Y520
PRAAHPRAPGEQQRL	RNF43	391	Q68DV7
LVQRHRIRGPPTRQD	SGSM2	201	O43147
PHQAQLRSPSQRPLR	SPPL2C	76	Q8IUH8
QALHGIPRDKPERPR	SHROOM2	816	Q13796
GPRRRNPRTTQHPLA	TAOK2	1131	Q9UL54
DPSRRERITAQHPLP	NPAS3	11	Q8IXF0
PSDGARRLLQPEHPR	PRDM1	471	O75626
RHQERLRVQSPEPPA	SCRIB	1466	Q14160
VQSRLLPPPLRHRSQ	STARD9	4011	Q9P2P6
LPPPLRHRSQRLGNS	STARD9	4016	Q9P2P6
RLPQSAGDLVRAHPP	NTAN1	11	Q96AB6
ARHPQVPEARDQGPI	SOWAHB	311	A6NEL2
PQPAVRHQGREPLLV	FAM90A15P	211	P0C7V4
RLHGLPEHRQPPRLQ	SPRY2	81	O43597
RHVQELRPIARPNPG	SSH3	441	Q8TE77
SPQHSLSNPLPRRVE	TLK2	111	Q86UE8
PPPVNHTTDRIFRRG	CHST1	141	O43916
PHGPRRASQDPQLLA	C10orf126	36	Q8N4M7
PEAIHLGPRQAVRPS	C11orf71	46	Q6IPW1
PRPGRQAPTHAKETR	C11orf87	116	Q6NUJ2
PRDQEPRGSHSPQRP	ZBTB48	161	P10074
HPQAREQGPSRRPGQ	TRAF3IP3	81	Q9Y228
IKHQRTHRGEQPPRP	ZNF48	236	Q96MX3
LRHQRAHEPPRPELR	ZNF865	976	P0CJ78
EHRLGRTREPPVNIQ	USP21	6	Q9UK80
ENQDPPPRSLARHLS	TIAM2	1081	Q8IVF5
PIERSQSPVHLRRPQ	SPEN	721	Q96T58
PPQTPPRRHRGLQAA	SPEG	2841	Q15772
PRRHRGLQAARPAEP	SPEG	2846	Q15772
AIPSSHPQPANRLRL	PAPLN	1031	O95428
QPERRQPPQRRHSIE	SPIRE1	511	Q08AE8
QDHPLQPPVRDLLRR	TRIM25	141	Q14258
RPPPRQQERAHLESL	TNS1	661	Q9HBL0
PLRRNPGNHDKSRTP	TYR	296	P14679
QQHRGLPPRQTMGRP	ZNF775	46	Q96BV0
AIHEERRRQQPPLGP	TBC1D10B	641	Q4KMP7
NKPVQGPLAHRDVPR	VWA5A	596	O00534
PRDPRHLGAQQRPAH	SORBS3	171	O60504
DRSHLQGAQARPPPE	ARHGAP31	416	Q2M1Z3
HRRGQSPLPRQRFPV	USB1	31	Q9BQ65
HLRIRECTAPPPRNG	UNC5D	326	Q6UXZ4
LRSDHQLVAGPPQPR	PRAG1	36	Q86YV5
AQHGRPPRPRNEEDA	UBA1	341	P22314
RLRHRLPNKQQPPDI	TBC1D4	936	O60343
PPFQNQQRPPRRGHR	PRR4	86	Q16378
QQRPPRRGHRQLSLP	PRR4	91	Q16378
PPPGLTPERLHARRQ	SLC30A3	61	Q99726
IHRELRPQGSARPQP	ZNF593	31	O00488
SPRPHRPNNDRLSIL	USP24	2081	Q9UPU5
ARARIQHRPPRQPTE	ZNRF3	201	Q9ULT6
TPSLRHRGQAAQPEP	TMUB1	71	Q9BVT8
RQGPTVLRGSRHPQP	THSD4	131	Q6ZMP0
NAISPQVPPHRRPGE	THSD4	531	Q6ZMP0
RIQRVPDSTHPRGPI	TGM7	511	Q96PF1
PRTFPEPAQLRRHLA	ZNF579	106	Q8NAF0
LGPGPRLRLVVNNHR	TFR2	391	Q9UP52
GAQDPGLQRRPRHRI	WASH6P	91	Q9NQA3
THQPERPRSPAARLL	ZNF219	106	Q9P2Y4
HIDRSDLNRQGPPPT	TRPC4	386	Q9UBN4
HLQGPPLALDPPRRQ	TPRX2	6	P0DV77
LPNPHPQLQLRGKRA	nan	21	Q6ZTC4
PGRPSRQPAVHPENL	TMC7	11	Q7Z402
NLRLLSRPVPDQRPH	ZNF34	181	Q8IZ26
TRPAQRPRAGGPHLE	TH	146	P07101
PQPAVRHQGREPLLV	FAM90A18	211	P0DV75
PPTNGLPHTQDRTKR	KIAA1522	991	Q9P206
QLNHRQIEPPFRPRI	PRKCH	621	P24723
PKEHSPSLRERRPQQ	MYO3A	1551	Q8NEV4
RREPPARRPDQIHSV	MYO9B	2096	Q13459
EAPSRQPRDQGQHPR	MYRIP	311	Q8NFW9
AGAHRLLREPPQQGR	NECAB2	11	Q7Z6G3