Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF726P1 ZNF727 ZBTB45 KMT2D ZNF142 ZNF30 TFAP2D CSRNP2 ZNF236 ZNF268 ZFP37 NPAS2	7.64e-05	1412	47	12	GO:0000981
Domain	MAGEA3/MAGEA6	MAGEA3 MAGEA6	5.68e-06	2	45	2	IPR030097
Domain	MAGE_N	MAGEA3 MAGEA6	1.05e-03	20	45	2	SM01392
Domain	-	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	1.11e-03	679	45	7	3.30.160.60
Domain	zf-C2H2	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	1.25e-03	693	45	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	1.26e-03	694	45	7	IPR013087
Domain	MAGE_N	MAGEA3 MAGEA6	1.27e-03	22	45	2	PF12440
Domain	MAGE_N	MAGEA3 MAGEA6	1.27e-03	22	45	2	IPR021072
Domain	ZINC_FINGER_C2H2_2	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	2.36e-03	775	45	7	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	2.40e-03	777	45	7	PS00028
Domain	Znf_C2H2-like	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	2.74e-03	796	45	7	IPR015880
Domain	Znf_C2H2	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	2.92e-03	805	45	7	IPR007087
Domain	ZnF_C2H2	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	2.98e-03	808	45	7	SM00355
Domain	MAGE	MAGEA3 MAGEA6	3.03e-03	34	45	2	SM01373
Domain	MAGE	MAGEA3 MAGEA6	3.39e-03	36	45	2	PS50838
Domain	MHD_dom	MAGEA3 MAGEA6	3.39e-03	36	45	2	IPR002190
Domain	MAGE	MAGEA3 MAGEA6	3.39e-03	36	45	2	PF01454
Domain	zf-C2H2_6	ZNF727 ZNF30 ZNF236 ZFP37	6.79e-03	314	45	4	PF13912
Pubmed	miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling.	MAGEA3 MAGEA6	1.79e-06	2	47	2	30056111
Pubmed	A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence.	MAGEA3 MAGEA6	1.79e-06	2	47	2	25564441
Pubmed	Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription.	KMT2D TFAP2D	1.07e-05	4	47	2	18495928
Pubmed	Degradation of AMPK by a cancer-specific ubiquitin ligase.	MAGEA3 MAGEA6	1.07e-05	4	47	2	25679763
Pubmed	Cloning and analysis of MAGE-1-related genes.	MAGEA3 MAGEA6	1.78e-05	5	47	2	8037761
Pubmed	Transmodulation between phospholipase D and c-Src enhances cell proliferation.	PLD1 CSK	2.67e-05	6	47	2	12697812
Pubmed	MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.	MAGEA3 MAGEA6	3.74e-05	7	47	2	22134685
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2D GRIN1	3.74e-05	7	47	2	19556342
Pubmed	Expression of melanoma-associated antigens in oral squamous cell carcinoma.	MAGEA3 MAGEA6	3.74e-05	7	47	2	18197853
Pubmed	AnkG hemizygous mice present cognitive impairment and elevated anxiety/depressive-like traits associated with decreased expression of GABA receptors and postsynaptic density protein.	GRIN1 ANK3	4.98e-05	8	47	2	28821923
Pubmed	MAGE cancer-testis antigens protect the mammalian germline under environmental stress.	MAGEA3 MAGEA6	4.98e-05	8	47	2	31149633
Pubmed	The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice.	MAGEA3 MAGEA6	4.98e-05	8	47	2	27226137
Pubmed	Next-generation sequencing to generate interactome datasets.	SLC41A2 MAGEA6 AP1M1 VPS52 TADA2A TRIP13 ITPRIPL1 EDRF1	1.37e-04	1147	47	8	21516116
Pubmed	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.	ATG2A WIPI2	1.38e-04	13	47	2	28561066
Pubmed	The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.	MAGEA3 MAGEA6	1.61e-04	14	47	2	8575766
Pubmed	Enhancer interaction networks as a means for singular olfactory receptor expression.	OR9G4 OR4E2	1.61e-04	14	47	2	25417106
Pubmed	Structure, chromosomal localization, and expression of 12 genes of the MAGE family.	MAGEA3 MAGEA6	1.86e-04	15	47	2	7927540
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR5AU1 OR4D10 OR9G4 OR4E2	2.21e-04	219	47	4	12213199
Pubmed	An Alternative Splicing Program for Mouse Craniofacial Development.	MYO1B OCRL	3.69e-04	21	47	2	33013468
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	AP1M1 WIPI2	5.26e-04	25	47	2	30340022
Pubmed	MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.	MAGEA3 MAGEA6	8.64e-04	32	47	2	20864041
Pubmed	Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.	MAGEA3 MAGEA6	9.19e-04	33	47	2	31143371
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5AU1 OR4D10 OR9G4 OR4E2	1.15e-03	340	47	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5AU1 OR4D10 OR9G4 OR4E2	1.15e-03	340	47	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5AU1 OR4D10 OR9G4 OR4E2	1.19e-03	343	47	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5AU1 OR4D10 OR9G4 OR4E2	1.23e-03	346	47	4	14611657
Pubmed	A census of human transcription factors: function, expression and evolution.	KMT2D ZNF30 TFAP2D ZNF236 ZNF268 NPAS2	1.34e-03	908	47	6	19274049
Interaction	ARNT2 interactions	AP1M1 VPS52 TADA2A TFAP2D NPAS2	2.49e-06	102	43	5	int:ARNT2
Cytoband	12q13.12	KMT2D FAM186B	7.04e-04	38	47	2	12q13.12
Cytoband	14q11.2	OR5AU1 OR4E2 CMA1	8.47e-04	180	47	3	14q11.2
Cytoband	2q11.2	ITPRIPL1 NPAS2	2.50e-03	72	47	2	2q11.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF727 ZBTB45 ZNF142 ZNF30 ZNF236 ZNF268 ZFP37	2.62e-04	718	33	7	28
GeneFamily	Autophagy related	ATG2A WIPI2	1.65e-03	33	33	2	1022
GeneFamily	MAGE family	MAGEA3 MAGEA6	2.41e-03	40	33	2	1136
Disease	level of Phosphatidylcholine (14:0_18:2) in blood serum	ABHD3 MUSK	2.78e-04	17	43	2	OBA_2045063
Disease	Schizoaffective Disorder	GRIN1 NPAS2	8.21e-04	29	43	2	C0036337
Disease	waist-hip ratio	CUL9 PLD1 TFAP2D ANK3 CSK ZNF268 NPAS2	1.83e-03	1226	43	7	EFO_0004343
Disease	lysophosphatidylcholine measurement	ABHD3 MUSK	3.71e-03	62	43	2	EFO_0010224
Disease	low density lipoprotein cholesterol measurement, physical activity	MUSK DDX18	4.19e-03	66	43	2	EFO_0003940, EFO_0004611

Protein segments in the cluster

Peptide	Gene	Start	Entry
TKLHLMNFTATYTRH	AZI2	271	Q9H6S1
RTHYLHTIMKLELES	CSRNP2	266	Q9H175
SVIEKHSHSRIEYMI	AP1M1	281	Q9BXS5
TSKESYILHMIHLSE	ABHD3	151	Q8WU67
VEHYRIMYHASKLSI	CSK	126	P41240
HYLRSKALELTTTTM	FAM186B	686	Q8IYM0
TLRLHKATLRHYMAL	ATG2A	1066	Q2TAZ0
VLSEMLNYLEKHTTH	TFAP2D	401	Q7Z6R9
QEHSEVYKILSSHML	NPAS2	136	Q99743
RALVETSYVKVLHHM	MAGEA3	276	P43357
RALIETSYVKVLHHM	MAGEA6	276	P43360
ISFLHLKVIYHTATM	MGAM2	991	Q2M2H8
IPYSKSHVSMAVHRI	EDRF1	136	Q3B7T1
STMTKHKSHLYLLVT	MINDY1	321	Q8N5J2
SYHKLMALDSTIAHL	LRRC71	211	Q8N4P6
LKELMTHHVHTYGLI	DDX18	271	Q9NVP1
KSHLLDYVMTTLLFS	TRIP13	146	Q15645
VILIRTDSHLHTPMY	OR9G4	61	Q8NGQ1
RPILTSYHFKTALMH	ITPRIPL1	441	Q6GPH6
INLYMHSLTHSTKSE	DNAH3	3326	Q8TD57
KEETHITTTTRMVYH	ANK3	2241	Q12955
LHRLASMHKDYAVVL	CUL9	1061	Q8IWT3
LLDRVFTTYKLMHTH	MIOX	36	Q9UGB7
ISKPLHYATIMSRDH	OR4D10	126	Q8NGI6
YLLSRHMAHKSEQIL	RHEX	31	Q6ZWK4
HALKMAVVDIYHSRL	TADA2A	201	O75478
KVMRHPDHVSSTVYL	PLD1	446	Q13393
HVSATLHTPMYSLLK	OR5AU1	101	Q8NGC0
LIFLYTIHLMKSGHT	SLC41A2	481	Q96JW4
SLYIHNIRDMKVLHT	WIPI2	136	Q9Y4P8
YDKLSVHVTALTHMP	SIGLEC12	261	Q96PQ1
LNYRSHMELKTSDHK	OCRL	511	Q01968
KYNTSTLHHDIMLLK	CMA1	101	P23946
RTLSMTLKHLDSYLA	VPS52	421	Q8N1B4
RYSSALKVHLRKHMS	ZNF30	606	P17039
YSSTLISHKRIHMEL	ZNF727	351	A8MUV8
SLRDYLLKHMVTHTG	ZBTB45	441	Q96K62
RSKSYLIIHMRTHTG	ZNF268	706	Q14587
TSYMVILVSLRKHSA	OR4E2	216	Q8NGC2
HMKTHYKIRVSSTRS	ZNF236	171	Q9UL36
VSYLSKHMLTHSNTK	ZNF142	441	P52746
MLSHKTQHKSIYTRE	ZNF726P1	1	Q15940
AFKYSSSLTKHMRIH	ZFP37	441	Q9Y6Q3
LTHYKRPHTLNSTSM	KMT2D	5346	O14686
SSDHLIEMATKLYRT	MYO1B	1066	O43795
KTHRGLYRSEMHLLS	MUSK	416	O15146
LTTRMSIYSDKSIHL	GRIN1	121	Q05586