Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH7 DNAH14 DNAH17 DNAH5 DNAH9	4.45e-09	18	162	6	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DYNC2H1 DNAH7 DNAH14 DNAH17 DNAH5 DNAH9	8.45e-08	28	162	6	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DYNC2H1 DNAH7 DNAH14 DNAH17 DNAH5 DNAH9	4.91e-07	37	162	6	GO:0045505
GeneOntologyMolecularFunction	microtubule motor activity	DYNC2H1 DNAH7 DNAH14 DNAH17 DNAH5 DNAH9	2.22e-05	70	162	6	GO:0003777
GeneOntologyMolecularFunction	calcium ion binding	CACNA1E DSG3 CDHR2 FKBP9 PCDHAC1 ACTN3 PKDREJ DNAH7 RAB44 THBS4 CELSR3 PLCH2 NCAN DSG4 PLCB4 PLCH1 NIN	1.29e-04	749	162	17	GO:0005509
GeneOntologyMolecularFunction	high-density lipoprotein particle binding	ABCA1 APOA1 APOL2	2.22e-04	15	162	3	GO:0008035
GeneOntologyMolecularFunction	cytoskeletal motor activity	DYNC2H1 DNAH7 DNAH14 DNAH17 DNAH5 DNAH9	4.05e-04	118	162	6	GO:0003774
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA1 DYNC2H1 UBA2 DNAH7 DNAH14 EIF4A2 DNAH17 ERCC6L2 TMEM30A DNAH5 DNAH9 ATP2B3 ATP4A ABCC10	4.94e-04	614	162	14	GO:0140657
GeneOntologyCellularComponent	dynein complex	DYNC2H1 DNAH7 DNAH14 DNAH17 DNAH5 DNAH9	4.32e-06	54	166	6	GO:0030286
GeneOntologyCellularComponent	axonemal dynein complex	DNAH7 DNAH17 DNAH5 DNAH9	4.26e-05	25	166	4	GO:0005858
GeneOntologyCellularComponent	outer dynein arm	DNAH17 DNAH5 DNAH9	1.03e-04	12	166	3	GO:0036157
GeneOntologyCellularComponent	TEAD-YAP complex	TEAD2 TEAD1	1.87e-04	3	166	2	GO:0140552
GeneOntologyCellularComponent	microvillus membrane	DPEP1 CDHR2 SLC7A8 SLC6A6	2.29e-04	38	166	4	GO:0031528
GeneOntologyCellularComponent	endoplasmic reticulum exit site	CTAGE6 CTAGE8 CTAGE15 CTAGE4	3.39e-04	42	166	4	GO:0070971
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH7 DNAH14 DNAH5 DNAH9	7.90e-08	14	159	5	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH7 DNAH14 DNAH5 DNAH9	7.90e-08	14	159	5	IPR024743
Domain	MT	DYNC2H1 DNAH7 DNAH14 DNAH5 DNAH9	7.90e-08	14	159	5	PF12777
Domain	AAA_8	DYNC2H1 DNAH7 DNAH14 DNAH5 DNAH9	7.90e-08	14	159	5	PF12780
Domain	DHC_fam	DYNC2H1 DNAH7 DNAH14 DNAH5 DNAH9	1.18e-07	15	159	5	IPR026983
Domain	Dynein_heavy	DYNC2H1 DNAH7 DNAH14 DNAH5 DNAH9	1.18e-07	15	159	5	PF03028
Domain	Dynein_heavy_dom	DYNC2H1 DNAH7 DNAH14 DNAH5 DNAH9	1.18e-07	15	159	5	IPR004273
Domain	TEA_1	TEAD2 TEAD1 TEAD3	2.41e-06	4	159	3	PS00554
Domain	TEA_2	TEAD2 TEAD1 TEAD3	2.41e-06	4	159	3	PS51088
Domain	TEA	TEAD2 TEAD1 TEAD3	2.41e-06	4	159	3	PF01285
Domain	TEA/ATTS_dom	TEAD2 TEAD1 TEAD3	2.41e-06	4	159	3	IPR000818
Domain	TEF_metazoa	TEAD2 TEAD1 TEAD3	2.41e-06	4	159	3	IPR016361
Domain	TEA	TEAD2 TEAD1 TEAD3	2.41e-06	4	159	3	SM00426
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH7 DNAH5 DNAH9	4.74e-06	14	159	4	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH7 DNAH5 DNAH9	4.74e-06	14	159	4	PF08393
Domain	DHC_N1	DYNC2H1 DNAH5 DNAH9	3.29e-05	8	159	3	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH5 DNAH9	3.29e-05	8	159	3	IPR013594
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH5 DNAH9	2.06e-04	14	159	3	IPR011704
Domain	AAA_5	DYNC2H1 DNAH5 DNAH9	2.06e-04	14	159	3	PF07728
Domain	ETS_PEA3_N	ETV1 ETV5	2.15e-04	3	159	2	IPR006715
Domain	ETS_PEA3_N	ETV1 ETV5	2.15e-04	3	159	2	PF04621
Domain	EF-hand_like	PLCH2 PLCB4 PLCH1	2.56e-04	15	159	3	PF09279
Domain	PI-PLC-Y	PLCH2 PLCB4 PLCH1	2.56e-04	15	159	3	PF00387
Domain	PLCYc	PLCH2 PLCB4 PLCH1	2.56e-04	15	159	3	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCH2 PLCB4 PLCH1	2.56e-04	15	159	3	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCH2 PLCB4 PLCH1	2.56e-04	15	159	3	PS50008
Domain	PI-PLC_fam	PLCH2 PLCB4 PLCH1	2.56e-04	15	159	3	IPR001192
Domain	PLC_EF-hand-like	PLCH2 PLCB4 PLCH1	2.56e-04	15	159	3	IPR015359
Domain	Desmoglein	DSG3 DSG4	4.27e-04	4	159	2	IPR009123
Domain	Alk_phosphatase	ALPI ALPG	4.27e-04	4	159	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPI ALPG	4.27e-04	4	159	2	IPR018299
Domain	Alkaline_phosphatase	ALPI ALPG	4.27e-04	4	159	2	IPR001952
Domain	alkPPc	ALPI ALPG	4.27e-04	4	159	2	SM00098
Domain	ALKALINE_PHOSPHATASE	ALPI ALPG	4.27e-04	4	159	2	PS00123
Domain	PI-PLC-X	PLCH2 PLCB4 PLCH1	4.50e-04	18	159	3	PF00388
Domain	PLCXc	PLCH2 PLCB4 PLCH1	4.50e-04	18	159	3	SM00148
Domain	C2_dom	GAK RASA1 RAB11FIP1 BCR PLCH2 PLCB4 PLCH1	5.17e-04	164	159	7	IPR000008
Domain	PIPLC_X_DOMAIN	PLCH2 PLCB4 PLCH1	5.31e-04	19	159	3	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCH2 PLCB4 PLCH1	5.31e-04	19	159	3	IPR000909
Domain	C2	RASA1 RAB11FIP1 BCR PLCH2 PLCB4 PLCH1	9.02e-04	131	159	6	PF00168
Domain	C2	RASA1 RAB11FIP1 BCR PLCH2 PLCB4 PLCH1	1.14e-03	137	159	6	SM00239
Domain	-	PLCH2 PLCB4 PLCH1	1.21e-03	25	159	3	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCH2 PLCB4 PLCH1	1.21e-03	25	159	3	IPR017946
Domain	C2	RASA1 RAB11FIP1 BCR PLCH2 PLCB4 PLCH1	1.37e-03	142	159	6	PS50004
Domain	AAA	ABCA1 DYNC2H1 DNAH7 DNAH5 DNAH9 ABCC10	1.47e-03	144	159	6	SM00382
Domain	AAA+_ATPase	ABCA1 DYNC2H1 DNAH7 DNAH5 DNAH9 ABCC10	1.47e-03	144	159	6	IPR003593
Domain	Desmosomal_cadherin	DSG3 DSG4	1.47e-03	7	159	2	IPR009122
Domain	-	RASA1 RAB11FIP1 BCR PLCH2 PLCB4 PLCH1	1.69e-03	148	159	6	2.60.40.150
Pathway	REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION	TEAD2 TEAD1 TEAD3	1.37e-05	6	126	3	MM15544
Pathway	REACTOME_HDL_ASSEMBLY	ABCA1 APOA1 PRKACB	2.38e-05	7	126	3	MM15560
Pathway	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	TEAD2 TEAD1 TEAD3	3.78e-05	8	126	3	MM14816
Pathway	REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION	TEAD2 TEAD1 TEAD3	3.78e-05	8	126	3	M27823
Pathway	REACTOME_HDL_ASSEMBLY	ABCA1 APOA1 PRKACB	3.78e-05	8	126	3	M27840
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	ITPKC PLCH2 PLCB4 PLCH1	7.81e-05	26	126	4	M27053
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH7 DNAH17 DNAH5 DNAH9	9.11e-05	27	126	4	M47755
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	ITPKC PLCH2 PLCB4 PLCH1	1.06e-04	28	126	4	MM14711
Pathway	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	TEAD2 TEAD1 TEAD3	2.93e-04	15	126	3	M603
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DYNC2H1 NPHP3 NODAL DNAH5	3.54e-07	13	167	4	17884984
Pubmed	A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.	TEAD2 TEAD1 TEAD3	4.33e-07	4	167	3	8702974
Pubmed	Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.	TEAD2 TEAD1 TEAD3	4.33e-07	4	167	3	36516960
Pubmed	Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis.	TEAD2 TEAD1 TEAD3	4.33e-07	4	167	3	9889009
Pubmed	The TEA domain: a novel, highly conserved DNA-binding motif.	TEAD2 TEAD1 TEAD3	4.33e-07	4	167	3	2070413
Pubmed	Tead transcription factors differentially regulate cortical development.	TEAD2 TEAD1 TEAD3	4.33e-07	4	167	3	32170161
Pubmed	Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse.	TEAD2 TEAD1 TEAD3	4.33e-07	4	167	3	9169843
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH7 DNAH17 DNAH5	4.94e-07	14	167	4	9373155
Pubmed	Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.	TEAD2 TEAD1 TEAD3	1.08e-06	5	167	3	9671946
Pubmed	Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.	TEAD2 TEAD1 TEAD3	1.08e-06	5	167	3	21527258
Pubmed	TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.	TEAD2 TEAD1 TEAD3	1.08e-06	5	167	3	19324877
Pubmed	Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.	TEAD2 TEAD1 TEAD3	1.08e-06	5	167	3	22677547
Pubmed	TEAD mediates YAP-dependent gene induction and growth control.	TEAD2 TEAD1 TEAD3	1.08e-06	5	167	3	18579750
Pubmed	TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.	TEAD2 TEAD1 TEAD3	1.08e-06	5	167	3	10518497
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PHLDA1 USP11 TSPYL2 ANGEL1 ZKSCAN2 PPP6R1 RAB11FIP1 BCR SP110 RCOR2 ZNF8 MLKL THADA WIZ BAZ2A CEP295 SIGLEC1 KPNA1 NIN	1.96e-06	1116	167	19	31753913
Pubmed	TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.	TEAD2 TEAD1 TEAD3	2.15e-06	6	167	3	11358867
Pubmed	Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.	TEAD2 TEAD1 TEAD3	2.15e-06	6	167	3	25995450
Pubmed	Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3.	TEAD2 TEAD1 TEAD3	3.75e-06	7	167	3	14736747
Pubmed	Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor.	TEAD2 TEAD1 TEAD3	3.75e-06	7	167	3	16207754
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH17 DNAH5 DNAH9	3.75e-06	7	167	3	31178125
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	DYNC2H1 CCDC39 NPHP3 DNAH5	6.00e-06	25	167	4	27340223
Pubmed	A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.	TEAD2 ETV5 TEAD1 RCOR2	6.00e-06	25	167	4	21536733
Pubmed	Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.	NODAL DNAH5 DNAH9	8.94e-06	9	167	3	27353389
Pubmed	Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases.	DSG3 IGHG3 IGHG4	1.74e-05	11	167	3	16492738
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E FLII ARHGEF12 PPP6R1 PEX5L BCR RCOR2 WIZ ATXN2 PTPRS EIF4A2 NCAN SYNE2 PRKACB DCLK1 KPNA1	1.78e-05	963	167	16	28671696
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLII DYNC2H1 RAB11FIP1 RNF17 BCR CCDC39 POLR1F MMP24 FASN THBS4 WIZ SYNE2 KDM8 KPNA1	1.83e-05	754	167	14	35906200
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MAN2A2 WFS1 FKBP9 PPP6R1 NCAPG2 PAICS NXPE3 SLC6A6 THADA CELSR3 METTL9 PTPRS FDFT1 LOXL1 LRP5 TMEM30A APOL2 IL6ST	2.07e-05	1201	167	18	35696571
Pubmed	Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1.	ABCA1 APOA1	2.29e-05	2	167	2	19258317
Pubmed	First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation.	ABCA1 APOA1	2.29e-05	2	167	2	31945064
Pubmed	Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells.	ABCA1 APOA1	2.29e-05	2	167	2	22389325
Pubmed	Myocardial infarction in a 36-year-old man with combined ABCA1 and APOA-1 deficiency.	ABCA1 APOA1	2.29e-05	2	167	2	26073400
Pubmed	Mutations in APOA-I and ABCA1 in Norwegians with low levels of HDL cholesterol.	ABCA1 APOA1	2.29e-05	2	167	2	20800056
Pubmed	Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I.	ABCA1 APOA1	2.29e-05	2	167	2	12869555
Pubmed	Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles.	ABCA1 APOA1	2.29e-05	2	167	2	12928428
Pubmed	Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I.	ABCA1 APOA1	2.29e-05	2	167	2	16418537
Pubmed	Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux.	ABCA1 APOA1	2.29e-05	2	167	2	12050168
Pubmed	The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease.	ABCA1 APOA1	2.29e-05	2	167	2	14747463
Pubmed	ABCA1 (ATP-Binding Cassette Transporter A1) Mediates ApoA-I (Apolipoprotein A-I) and ApoA-I Mimetic Peptide Mobilization of Extracellular Cholesterol Microdomains Deposited by Macrophages.	ABCA1 APOA1	2.29e-05	2	167	2	27758769
Pubmed	Novel Insights into Concepts and Directionality of Maternal⁻Fetal Cholesterol Transfer across the Human Placenta.	ABCA1 APOA1	2.29e-05	2	167	2	30096856
Pubmed	The lipidation by hepatocytes of human apolipoprotein A-I occurs by both ABCA1-dependent and -independent pathways.	ABCA1 APOA1	2.29e-05	2	167	2	12547832
Pubmed	Expression of protein-tyrosine phosphatases in the major insulin target tissues.	PTPRA PTPRS	2.29e-05	2	167	2	9357975
Pubmed	Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter.	ABCA1 APOA1	2.29e-05	2	167	2	14701824
Pubmed	Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.	ABCA1 APOA1	2.29e-05	2	167	2	14967052
Pubmed	ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I.	ABCA1 APOA1	2.29e-05	2	167	2	14703508
Pubmed	ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes.	ABCA1 APOA1	2.29e-05	2	167	2	14993246
Pubmed	Increased prevalence of clinical and subclinical atherosclerosis in patients with damaging mutations in ABCA1 or APOA1.	ABCA1 APOA1	2.29e-05	2	167	2	29150341
Pubmed	ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology.	ABCA1 APOA1	2.29e-05	2	167	2	15632021
Pubmed	Potential involvement of dissociated apoA-I in the ABCA1-dependent cellular lipid release by HDL.	ABCA1 APOA1	2.29e-05	2	167	2	14729855
Pubmed	A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.	ABCA1 APOA1	2.29e-05	2	167	2	12511593
Pubmed	Characterization and properties of pre beta-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I.	ABCA1 APOA1	2.29e-05	2	167	2	18252847
Pubmed	Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability.	ABCA1 APOA1	2.29e-05	2	167	2	23543682
Pubmed	Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers.	ABCA1 APOA1	2.29e-05	2	167	2	22750655
Pubmed	The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.	ABCA1 APOA1	2.29e-05	2	167	2	12488454
Pubmed	Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport.	ABCA1 APOA1	2.29e-05	2	167	2	15574409
Pubmed	Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains.	ABCA1 APOA1	2.29e-05	2	167	2	11929608
Pubmed	Structure-function analysis of naturally occurring apolipoprotein A-I L144R, A164S and L178P mutants provides insight on their role on HDL levels and cardiovascular risk.	ABCA1 APOA1	2.29e-05	2	167	2	32666307
Pubmed	Correlation Between ABCA1 Gene Polymorphism and aopA-I and HDL-C in Abdominal Aortic Aneurysm.	ABCA1 APOA1	2.29e-05	2	167	2	26774504
Pubmed	Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo.	ABCA1 APOA1	2.29e-05	2	167	2	18622028
Pubmed	The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1.	ABCA1 APOA1	2.29e-05	2	167	2	21889608
Pubmed	Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo.	ABCA1 APOA1	2.29e-05	2	167	2	18033752
Pubmed	ABCA1, ApoA-I and type II DM.	ABCA1 APOA1	2.29e-05	2	167	2	16009332
Pubmed	N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis.	ABCA1 APOA1	2.29e-05	2	167	2	30249788
Pubmed	TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation.	TEAD1 TEAD3	2.29e-05	2	167	2	32142794
Pubmed	Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.	ABCA1 APOA1	2.29e-05	2	167	2	12084722
Pubmed	PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.	PTPRS NCAN	2.29e-05	2	167	2	19833921
Pubmed	Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.	PLCH2 PLCH1	2.29e-05	2	167	2	15583837
Pubmed	Quantitative analysis of ABCA1-dependent compartmentalization and trafficking of apolipoprotein A-I: implications for determining cellular kinetics of nascent high density lipoprotein biogenesis.	ABCA1 APOA1	2.29e-05	2	167	2	18218626
Pubmed	CTRP1 decreases ABCA1 expression and promotes lipid accumulation through the miR-424-5p/FoxO1 pathway in THP-1 macrophage-derived foam cells.	ABCA1 C1QTNF1	2.29e-05	2	167	2	34288211
Pubmed	Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis.	ABCA1 APOA1	2.29e-05	2	167	2	21846716
Pubmed	Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).	ABCA1 APOA1	2.29e-05	2	167	2	14660648
Pubmed	Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I.	ABCA1 APOA1	2.29e-05	2	167	2	16126721
Pubmed	ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels.	ABCA1 APOA1	2.29e-05	2	167	2	24793484
Pubmed	ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments.	ABCA1 APOA1	2.29e-05	2	167	2	18385134
Pubmed	Lysine residues of ABCA1 are required for the interaction with apoA-I.	ABCA1 APOA1	2.29e-05	2	167	2	21749932
Pubmed	Charged Residues in the C-Terminal Domain of Apolipoprotein A-I Modulate Oligomerization.	ABCA1 APOA1	2.29e-05	2	167	2	29578333
Pubmed	ABCA1-Derived Nascent High-Density Lipoprotein-Apolipoprotein AI and Lipids Metabolically Segregate.	ABCA1 APOA1	2.29e-05	2	167	2	29074589
Pubmed	ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells.	ABCA1 APOA1	2.29e-05	2	167	2	19528336
Pubmed	Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation.	ABCA1 APOA1	2.29e-05	2	167	2	19170766
Pubmed	Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles.	ABCA1 APOA1	2.29e-05	2	167	2	17604270
Pubmed	RNF216 regulates meiosis and PKA stability in the testes.	PRKACB RNF216	2.29e-05	2	167	2	33724554
Pubmed	Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages.	ABCA1 APOA1	2.29e-05	2	167	2	14734645
Pubmed	Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles.	ABCA1 APOA1	2.29e-05	2	167	2	15280376
Pubmed	Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts.	ABCA1 APOA1	2.29e-05	2	167	2	15292375
Pubmed	Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1.	ABCA1 APOA1	2.29e-05	2	167	2	30458687
Pubmed	High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion.	VWF APOA1	2.29e-05	2	167	2	26552698
Pubmed	Human immunodeficiency virus impairs reverse cholesterol transport from macrophages.	ABCA1 APOA1	2.29e-05	2	167	2	17076584
Pubmed	An abundant dysfunctional apolipoprotein A1 in human atheroma.	ABCA1 APOA1	2.29e-05	2	167	2	24464187
Pubmed	The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons.	RELN HTR3A	2.29e-05	2	167	2	19366679
Pubmed	Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL.	ABCA1 APOA1	2.29e-05	2	167	2	18583707
Pubmed	ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation.	ABCA1 APOA1	2.29e-05	2	167	2	18617649
Pubmed	Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1.	ABCA1 APOA1	2.29e-05	2	167	2	17510466
Pubmed	Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1.	ABCA1 APOA1	2.29e-05	2	167	2	15051721
Pubmed	Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway.	ABCA1 APOA1	2.29e-05	2	167	2	20378541
Pubmed	ABCA1 and nascent HDL biogenesis.	ABCA1 APOA1	2.29e-05	2	167	2	25359426
Pubmed	Denaturation of human plasma high-density lipoproteins by urea studied by apolipoprotein A-I dissociation.	ABCA1 APOA1	2.29e-05	2	167	2	32961276
Pubmed	On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway.	ABCA1 APOA1	2.29e-05	2	167	2	15520446
Pubmed	PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.	ABCA1 APOA1	2.29e-05	2	167	2	27514935
Pubmed	Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling.	ABCA1 APOA1	2.29e-05	2	167	2	19965585
Pubmed	Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice.	ABCA1 APOA1	2.29e-05	2	167	2	20739292
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 DYNC2H1 GBA2 VPS13D THADA NPHP3 IPO9 DSTYK DNAH17 KLHL14 PLCH1	2.88e-05	493	167	11	15368895
Interaction	CTAGE1 interactions	CTAGE6 CTAGE8 CTAGE15 CTAGE4	8.97e-07	10	166	4	int:CTAGE1
Cytoband	7q35	CTAGE6 CTAGE8 CTAGE15 CTAGE4	4.98e-05	55	167	4	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	CTAGE6 CTAGE8 CTAGE15 CTAGE4	1.02e-04	66	167	4	chr7q35
Cytoband	18q12.1	DSG3 DSG4 KLHL14	1.16e-04	26	167	3	18q12.1
Cytoband	19p12	ZNF208 ZNF676 NCAN ZNF726	3.38e-04	90	167	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr18q12	DSG3 ZSCAN30 DSG4 KLHL14	5.85e-04	104	167	4	chr18q12
Cytoband	19q13.1	ITPKC FCGBP ATP4A	1.08e-03	55	167	3	19q13.1
GeneFamily	Dyneins, axonemal	DNAH7 DNAH14 DNAH17 DNAH5 DNAH9	6.32e-08	17	118	5	536
GeneFamily	TEA domain transcription factors	TEAD2 TEAD1 TEAD3	1.08e-06	4	118	3	1183
GeneFamily	CTAGE family	CTAGE6 CTAGE8 CTAGE15 CTAGE4	2.23e-06	15	118	4	907
GeneFamily	Alkaline phosphatases	ALPI ALPG	2.51e-04	4	118	2	1072
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRA PTPRO PTPRS	3.31e-04	21	118	3	813
GeneFamily	Desmosomal cadherins	DSG3 DSG4	8.68e-04	7	118	2	1188
GeneFamily	Phospholipases	PLCH2 PLCB4 PLCH1	2.58e-03	42	118	3	467
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMCX3 THADA KPNA1	2.77e-03	43	118	3	409
GeneFamily	EF-hand domain containing	CACNA1E FKBP9 DNAH7 PLCH2 PLCH1 NIN	3.15e-03	219	118	6	863
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	IL1RAPL1 PTPRS CNTN5 UNC5C SIGLEC1	4.10e-03	161	118	5	593
GeneFamily	Endogenous ligands\|C1q and TNF related	C1QTNF1 C1QTNF7	6.04e-03	18	118	2	1372
GeneFamily	Armadillo repeat containing\|Importins	IPO9 KPNA1	6.04e-03	18	118	2	596
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	DYNC2H1 ARHGEF12 TEAD1 DNAH7 SYNE2 PLCB4 PLCH1 DNAH5 DNAH9	5.56e-08	195	167	9	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	DYNC2H1 ARHGEF12 TEAD1 DNAH7 SYNE2 PLCB4 PLCH1 DNAH5 DNAH9	5.56e-08	195	167	9	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	DYNC2H1 TEAD1 DNAH7 SYNE2 PLCB4 PLCH1 DNAH5 DNAH9	7.58e-07	195	167	8	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	ARHGEF12 TEAD1 DNAH7 SYNE2 PLCB4 PLCH1 DNAH5 DNAH9	7.88e-07	196	167	8	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	ARHGEF12 TEAD1 DNAH7 SYNE2 PLCB4 PLCH1 DNAH5 DNAH9	7.88e-07	196	167	8	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	facs-Lung-18m-Hematologic-myeloid-leukocyte-proliferating_myeloid_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STIL RNF17 SLC7A8 TGM1 SMPDL3B PLCH2 SIGLEC1	1.84e-06	153	167	7	596bb7cfd1c713708ce73df30d890a0233eae7f7
ToppCell	facs-Lung-18m-Hematologic-myeloid-leukocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STIL RNF17 SLC7A8 TGM1 SMPDL3B PLCH2 SIGLEC1	1.84e-06	153	167	7	8cc2667213bfac37545bb63181e88ef1f1834413
ToppCell	droplet-Thymus-nan-21m-Myeloid-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 HLA-DMA NPHP3 APOBEC2 DNAH17 RASSF3 NODAL	3.42e-06	168	167	7	69dd747be46e7fbcec571cddd6dee374b9c2507a
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 ABCA1 HLA-DMA SLC7A8 SMPDL3B PTPRO SIGLEC1	4.31e-06	174	167	7	1802a52552256d1e25d8b328ba62dcfe41671900
ToppCell	facs-Heart-LA-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 ABCA1 HLA-DMA SLC7A8 SMPDL3B PTPRO SIGLEC1	4.31e-06	174	167	7	30c083fe4711735e83dccfd00fcd746ae673d353
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 ABCA1 HLA-DMA SLC7A8 SMPDL3B PTPRO SIGLEC1	4.31e-06	174	167	7	46d19c1144fff19be682b7ba59d4c3e014f79e15
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 CYRIA SMPDL3B SYNE2 PRKACB RASSF3 NIN	4.48e-06	175	167	7	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	Ciliated_cells-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	DYNC2H1 UBA2 DNAH7 CCDC39 DNAH5 DNAH9 ATP2B3	5.80e-06	182	167	7	e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCell	Basal\|World / shred by cell class for mouse tongue	ABCA1 MAN2A2 RBBP8 FKBP9 PAICS SLC6A6 PTPRS	6.01e-06	183	167	7	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gad2-Fos_(IEG_state,_GABAergic)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	HTR3A PCDHAC1 ACTN3 STIL THBS4	6.61e-06	70	167	5	e1ac00f4a519b6ada89f591e549874bd3eed0ca1
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gad2-Fos_(IEG_state,_GABAergic)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	HTR3A PCDHAC1 ACTN3 STIL THBS4	6.61e-06	70	167	5	27e12c0f43a996bcbed285c5ee668bef5a786d80
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gad2-Fos_(IEG_state,_GABAergic)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	HTR3A PCDHAC1 ACTN3 STIL THBS4	6.61e-06	70	167	5	b6815131e87e81c10e65bc398a84dab5a74b32ac
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	SP110 ADAR PARP10 TGM1 SYNE2 APOL2 IL6ST	7.17e-06	188	167	7	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	droplet-Heart-nan-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FAM161B CITED1 PEX5L RCOR2 IL1RAPL1 BRINP2	7.42e-06	189	167	7	0493f7b79127c207fd7ade778ef4810500495d7e
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PRUNE2 RELN WFS1 RAB11FIP1 THBS4 ABCC10 CEP19	8.22e-06	192	167	7	b016e229300c183e14c0e2bba494bf49c7899112
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PRUNE2 RELN WFS1 RAB11FIP1 THBS4 ABCC10 CEP19	8.22e-06	192	167	7	ac96831492c62ad9e1f7d0b764fbdf7d8a189ad9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RBBP8 DNAH7 LLGL2 SYNE2 MOB3B PLCH1 DNAH5	8.80e-06	194	167	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPEP1 PHLDA1 FKBP9 ETV1 LOXL1 UNC5C C1QTNF7	9.09e-06	195	167	7	cbe518b465b4ef32797ae6b608219207c08493df
ToppCell	PND03-Mesenchymal-Mesenchymal_structural\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPEP1 PHLDA1 FKBP9 ETV1 LOXL1 UNC5C C1QTNF7	9.09e-06	195	167	7	136b06b0931a69b1241101f68c01c44c70365fd9
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Sla\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HLA-DMA WFS1 WIPF3 GLRA3 SMPDL3B SLC16A2	1.06e-05	132	167	6	ddebc0b233fdbb73ceb70187945bbed8fd273f2a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Cilia-bearing_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	DNAH7 CCDC39 SLC7A8 SLC17A8 DNAH5 DNAH9 ATP2B3	1.07e-05	200	167	7	177f9ad8dd8635394c575a2b30140184df0bd51e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SIGLEC9 RNF17 NXPE3 IL1RAPL1 IGHG3 UNC5C	2.04e-05	148	167	6	f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SIGLEC9 RNF17 NXPE3 IL1RAPL1 IGHG3 UNC5C	2.04e-05	148	167	6	55826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SIGLEC9 RNF17 NXPE3 IL1RAPL1 IGHG3 UNC5C	2.04e-05	148	167	6	4b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KLHL1 RASA1 FASN PTPRA SYNE2 IL6ST	2.20e-05	150	167	6	c922dbb4c9c12ccf08bd5f6168b20606c605d052
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RELN DNAH7 CNTN5 C1QTNF7 CLUL1 PLCH1	2.55e-05	154	167	6	4e9203c220a44c70cd7979796a0b461991422257
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RELN DNAH7 CNTN5 C1QTNF7 CLUL1 PLCH1	2.94e-05	158	167	6	8e48952af0831a1fc71ad422e8216b5a92a75991
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RELN DNAH7 CNTN5 C1QTNF7 CLUL1 PLCH1	2.94e-05	158	167	6	e5b55c15a8c99c8d7fc94949f0d3c22e0c3fee7b
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RELN DNAH7 CNTN5 C1QTNF7 CLUL1 PLCH1	2.94e-05	158	167	6	55214d674808584e4d48f8c5e3b8c0e206cb9bb8
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ETV5 NXPE3 ZSCAN29 CDAN1 PEDS1 SIGLEC1	3.51e-05	163	167	6	63b0badaee3b2d827b1f4524510e3384d8f8fcde
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN GLRA3 IL1RAPL1 CNTN5 DNAH9 DCLK1	3.51e-05	163	167	6	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	343B-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DPEP1 CCDC39 SMPDL3B PTPRS IGHG3 IGHG4	3.63e-05	164	167	6	cf62d34ce9dd220fe61748466c84fd70d9ba697c
ToppCell	343B-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DPEP1 CCDC39 SMPDL3B PTPRS IGHG3 IGHG4	3.63e-05	164	167	6	e00549bc8b3a5566f39031f39d7e698b0b107a7f
ToppCell	facs-Heart-LV-24m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 ARHGAP40 HLA-DMA FCGBP SMPDL3B PTPRO	3.75e-05	165	167	6	41707e66542ea27133043740ef9e58ab89b06607
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG3 PCDHAC1 CELSR3 SLC17A8 DSG4 ATP2B3	4.02e-05	167	167	6	95b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG3 PCDHAC1 CELSR3 SLC17A8 DSG4 ATP2B3	4.02e-05	167	167	6	3dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG3 PCDHAC1 CELSR3 SLC17A8 DSG4 ATP2B3	4.02e-05	167	167	6	9480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 GAK RAB44 CYRIA SMPDL3B DSTYK	4.15e-05	168	167	6	e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCell	facs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 HLA-DMA SLC7A8 SMPDL3B PTPRO PEDS1	4.29e-05	169	167	6	8180aeda13c511260d0542a94156059d558848a7
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA1 PHLDA1 DYNC2H1 IL1RAPL1 ADAMTS14 IL6ST	4.29e-05	169	167	6	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 TEAD1 RAB11FIP1 LLGL2 DCLK1 ALPG	4.89e-05	173	167	6	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	FAM161B BCR GBA2 CDAN1 PLCH2 ZNF74	5.05e-05	174	167	6	390bd41ef114464f3db3e0cac4e67fe7571b4c23
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E RELN WIPF3 TEAD1 BCR THBS4	5.21e-05	175	167	6	9d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E RELN WIPF3 TEAD1 BCR THBS4	5.21e-05	175	167	6	f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell	10x5'-blood-Lymphocytic_B_plasma-Plasmablasts\|blood / Manually curated celltypes from each tissue	DPEP1 STIL CDAN1 IGHG3 IGHG4 KLHL14	5.21e-05	175	167	6	2e048bf7961c3d86b6e12a1ebae3b3f2359af457
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 ETV1 SLC7A8 MMP24 CYRIA SIGLEC1	5.55e-05	177	167	6	26bad614560609d318bfc9c235a698bca4e1c22c
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TEAD2 VWF WIPF3 MYRFL SLC16A2 IL6ST	5.55e-05	177	167	6	6f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	PRUNE2 PCDHAC1 TEAD1 PRKACB PLCB4 DCLK1	5.91e-05	179	167	6	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TEAD2 VWF CITED1 ACTN3 MMP24	5.91e-05	179	167	6	b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HTR3A WIPF3 GLRA3 PEX5L CELSR3 CNTN5	5.91e-05	179	167	6	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	facs-Kidney-nan-24m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WIPF3 RAB44 LOXL1 TLE6 C1QTNF1 C1QTNF7	6.09e-05	180	167	6	f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ELMOD2 ANGEL1 MMP24 ATXN2 UNC5C KDM8	6.09e-05	180	167	6	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 RELN MAN2A2 ANGEL1 TEAD1 LOXL1	7.30e-05	186	167	6	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 RELN MAN2A2 ANGEL1 TEAD1 LOXL1	7.30e-05	186	167	6	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 RELN MAN2A2 ANGEL1 TEAD1 LOXL1	7.30e-05	186	167	6	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DPEP1 SLC47A2 SYNE2 PLCB4 DCLK1	7.30e-05	186	167	6	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CDHR2 SLC47A2 SLC6A6 CNTN5 SYNE2	7.30e-05	186	167	6	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	Tuft-tuft-2\|World / Class top	COPRS ETV1 RAB44 CYRIA ATP4A DCLK1	7.52e-05	187	167	6	4ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCell	Endothelial-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	TEAD2 RELN VWF CCDC39 IGHG4 APOL2	7.75e-05	188	167	6	ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PHLDA1 ETV5 PTPRO PTPRS NCAN	7.75e-05	188	167	6	006db2c2c44971ca9241c582bc89f258c785f5ed
ToppCell	severe_COVID-19-Plasmablast\|World / disease group, cell group and cell class (v2)	DPEP1 WFS1 STIL SMPDL3B IGHG3 IGHG4	7.75e-05	188	167	6	25ca19af4ac419a0f5026a6ccbd8b554b268a6f3
ToppCell	Fibroblast-A\|World / shred on cell class and cell subclass (v4)	DPEP1 PHLDA1 FKBP9 ETV1 LOXL1 UNC5C	7.75e-05	188	167	6	6740bed5fb8f45b6eea17041894b804214c2a4ae
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PHLDA1 ETV5 PTPRO PTPRS NCAN	7.75e-05	188	167	6	d0e6fb4a3b3d79d3512b5500062ea285495ae526
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RBBP8 MYRFL DNAH7 DNAH14 LLGL2 DNAH5	8.21e-05	190	167	6	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	DPEP1 WFS1 ETV5 SMPDL3B IGHG3 IGHG4	8.21e-05	190	167	6	ce70336679a2b713836e7497e6dc48aac612b018
ToppCell	droplet-Lung-nan-18m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 FKBP9 ACTN3 LOXL1 C1QTNF7 DCLK1	8.21e-05	190	167	6	72c2b824acdc43139e6635785df3ed3feb58ec46
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PRUNE2 RELN WFS1 RAB11FIP1 CYRIA KLHL14	8.21e-05	190	167	6	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASA1 ETV1 ARHGEF12 SLC6A6 C1QTNF7 NIN	8.21e-05	190	167	6	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 FKBP9 ACTN3 LOXL1 C1QTNF7 DCLK1	8.21e-05	190	167	6	97772e69e6f51ebffbb5433ca7b40f1048723220
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	DPEP1 FKBP9 ETV1 PTPRS LOXL1 C1QTNF7	8.45e-05	191	167	6	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	Enterocyte_Progenitors-C_06\|Enterocyte_Progenitors / shred on cell type and cluster	PRUNE2 ARHGAP40 PHLDA1 FCGBP IGHG3 IGHG4	8.70e-05	192	167	6	b9938e1a929c00628cc6ebfdf10cf285167f445c
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ETV5 DNAH14 ITPKC FASN PLCH1 DNAH5	8.70e-05	192	167	6	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	ETV1 ETV5 DNAH14 FASN PLCH1 DNAH5	8.70e-05	192	167	6	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	Healthy_donor-B_intermediate\|World / disease group, cell group and cell class (v2)	TEAD2 HLA-DMA GLRA3 IGHG3 IGHG4 LRP5	8.70e-05	192	167	6	f77007b284e11f8654ad599eef929df7c6c4ebf0
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP40 RBBP8 DNAH7 LLGL2 SYNE2 DNAH5	8.95e-05	193	167	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 FKBP9 LOXL1 C1QTNF1 C1QTNF7 DCLK1	8.95e-05	193	167	6	160691b671710be10220803d788c2c961c236af1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP40 RBBP8 DNAH7 LLGL2 SYNE2 DNAH5	8.95e-05	193	167	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 FKBP9 THBS4 LOXL1 C1QTNF1 DCLK1	8.95e-05	193	167	6	428b1a3ad87dff7f65de5161d40f102572a9341b
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ABCA1 WIPF3 MYRFL DNAH14 UNC5C PLCB4	8.95e-05	193	167	6	826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 PHLDA1 FKBP9 LOXL1 C1QTNF7 DCLK1	9.21e-05	194	167	6	da926441053b499cb5107ccb116fb1b3844d82b7
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 DNAH7 CCDC39 PLCH1 DNAH5 DNAH9	9.21e-05	194	167	6	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 PHLDA1 FKBP9 LOXL1 C1QTNF7 DCLK1	9.21e-05	194	167	6	f34b3bbdebf56f66ff499e390e5515a4a4093f90
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 TEAD1 SLC47A2 DNAH14 LLGL2 SYNE2	9.21e-05	194	167	6	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	ABCA1 ZNF710 SLC7A8 CYRIA MOB3B SIGLEC1	9.21e-05	194	167	6	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 PHLDA1 FKBP9 LOXL1 C1QTNF7 DCLK1	9.21e-05	194	167	6	54a7f693966b5c02f6b248950ddb5fa32af3ae67
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPEP1 PHLDA1 FKBP9 ETV1 LOXL1 UNC5C	9.47e-05	195	167	6	1c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PEX5L RCOR2 TGM1 ZNF676 IGHG4 C1QTNF1	9.47e-05	195	167	6	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPEP1 PHLDA1 FKBP9 ETV1 LOXL1 UNC5C	9.47e-05	195	167	6	1f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PEX5L RCOR2 TGM1 ZNF676 IGHG4 C1QTNF1	9.47e-05	195	167	6	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	DNAH7 CCDC39 PLCH2 SLC17A8 DNAH5 DNAH9	9.47e-05	195	167	6	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPEP1 PHLDA1 FKBP9 ETV1 LOXL1 UNC5C	9.74e-05	196	167	6	14246f00c90741a5f8683f377e22e3a7c99661b9
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	DPEP1 FKBP9 ETV1 PTPRS LOXL1 C1QTNF7	9.74e-05	196	167	6	54f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPEP1 PHLDA1 FKBP9 ETV1 LOXL1 UNC5C	9.74e-05	196	167	6	2a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	DYNC2H1 TEAD1 DNAH7 PLCH1 DNAH5 DNAH9	9.74e-05	196	167	6	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 DNAH7 CCDC39 PLCH1 DNAH5 DNAH9	1.00e-04	197	167	6	6865f4831eb23794fb88a8649d48d497bbae3f44
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	C14orf93 MAN2A2 CHM SLC6A6 WIZ BAZ2A DNAH17 MOB3B KDM8 IL6ST	1.93e-06	197	166	10	3930_DN
Drug	Trimethoprim [738-70-5]; Up 200; 13.8uM; MCF7; HT_HG-U133A	RELN ELOA2 HTR3A RNF17 VPS13D WIZ PTPRO CNTN5 PLCH1 DCLK1	1.93e-06	197	166	10	2307_UP
Drug	Trimipramine maleate salt [521-78-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A	ELOA2 HTR3A PHLDA1 CDHR2 SLC6A6 WIZ APOBEC2 BRINP2 PLCH1 IL6ST	2.02e-06	198	166	10	3342_UP
Drug	0317956-0000 [391210-11-0]; Down 200; 10uM; MCF7; HT_HG-U133A	PHLDA1 CDHR2 ETV5 ZNF710 SLC6A6 WIZ BRINP2 MOB3B KDM8	1.11e-05	190	166	9	3966_DN
Drug	Rapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A	TSPYL2 ETV5 CHM ITPKC CYRIA BAZ2A APOBEC2 DSTYK IL6ST	1.37e-05	195	166	9	6180_DN
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; HL60; HT_HG-U133A	ELOA2 CDHR2 ANGEL1 PAICS ZNF710 ITPKC VPS13D PTPRO DSTYK	1.49e-05	197	166	9	2569_DN
Drug	Moricizine hydrochloride [31883-05-3]; Down 200; 8.6uM; HL60; HT_HG-U133A	TSPYL2 ST7L CHM PAICS ZNF710 THADA WIZ PTPRO ABCC10	1.55e-05	198	166	9	2959_DN
Drug	Naftopidil dihydrochloride [57149-08-3]; Down 200; 8.6uM; MCF7; HT_HG-U133A	C14orf93 PHLDA1 SP110 VPS13D WIZ CELSR3 BAZ2A PLCH1 APOL2	1.61e-05	199	166	9	7331_DN
Drug	Pyrimethamine [58-14-0]; Up 200; 16uM; MCF7; HT_HG-U133A	RELN MAN2A2 MMP24 VPS13D PTPRA PTPRS DNAH17 BRINP2 APOL2	1.68e-05	200	166	9	1474_UP
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; HL60; HT_HG-U133A	ELOA2 CHM BCR VPS13D THADA DSTYK ZNF74 APOL2 ABCC10	1.68e-05	200	166	9	3010_DN
Disease	Apolipoprotein A-I deficiency	ABCA1 APOA1	2.92e-05	2	160	2	C0342898
Disease	hypolipoproteinemia (is_implicated_in)	ABCA1 APOA1	2.92e-05	2	160	2	DOID:1387 (is_implicated_in)
Disease	Familial hypoalphalipoproteinemia	ABCA1 APOA1	2.92e-05	2	160	2	cv:C1704429
Disease	Hypoalphalipoproteinemia, Familial	ABCA1 APOA1	2.92e-05	2	160	2	C1704429
Disease	Situs ambiguus	NODAL DNAH5 DNAH9	6.79e-05	15	160	3	C0266642
Disease	sensorineural hearing loss (implicated_via_orthology)	SLC7A8 DNAH17 DNAH9	1.42e-04	19	160	3	DOID:10003 (implicated_via_orthology)
Disease	Ciliopathies	DYNC2H1 CCDC39 NPHP3 NODAL DNAH5	3.41e-04	110	160	5	C4277690
Disease	Antiglaucoma preparations and miotics use measurement	ABCA1 FNBP4 LOXL1	3.71e-04	26	160	3	EFO_0009944
Disease	immature platelet fraction	VWF ST7L CYRIA BAZ2A RASSF3	4.02e-04	114	160	5	EFO_0009187
Disease	childhood onset asthma, age at onset, environmental tobacco smoke exposure measurement	KLHL1 NIN	4.32e-04	6	160	2	EFO_0004847, EFO_0008361, MONDO_0005405
Disease	intraocular pressure measurement	RELN ABCA1 DYNC2H1 ETV1 ARHGEF12 ST7L THBS4 THADA NPHP3 ATXN2	4.85e-04	509	160	10	EFO_0004695
Disease	Phencyclidine-Related Disorders	FDFT1 APOL2	6.03e-04	7	160	2	C0236742
Disease	bipolar disorder (implicated_via_orthology)	ETV1 ETV5	6.03e-04	7	160	2	DOID:3312 (implicated_via_orthology)
Disease	glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement	GBA2 SYNE2	6.03e-04	7	160	2	EFO_0800551
Disease	Phencyclidine Abuse	FDFT1 APOL2	6.03e-04	7	160	2	C0031391
Disease	angina pectoris	DYNC2H1 ARHGEF12 IPO9 LOXL1 UNC5C	6.12e-04	125	160	5	EFO_0003913
Disease	t-cell surface glycoprotein CD5 measurement	SIGLEC9 ATXN2	1.03e-03	9	160	2	EFO_0803134
Disease	Situs ambiguous	NODAL DNAH9	1.03e-03	9	160	2	C1167664
Disease	lipoprotein measurement, phospholipid measurement	ABCA1 APOA1 ATXN2 NCAN	1.20e-03	85	160	4	EFO_0004639, EFO_0004732
Disease	Cannabis Abuse	FDFT1 APOL2	1.28e-03	10	160	2	C0006868
Disease	Cannabis-Related Disorder	FDFT1 APOL2	1.28e-03	10	160	2	C0236735
Disease	Hashish Abuse	FDFT1 APOL2	1.28e-03	10	160	2	C0018614
Disease	lipid measurement, lipoprotein measurement	ABCA1 ATXN2 FDFT1 NCAN	1.48e-03	90	160	4	EFO_0004529, EFO_0004732
Disease	Situs Inversus	NODAL DNAH9	1.56e-03	11	160	2	C0037221
Disease	reticulocyte count	ABCA1 VWF FKBP9 THADA PTPRA ATXN2 FDFT1 DSTYK CNTN5 DNAH17 SYNE2 LRP5 RASSF3 HERC1	1.72e-03	1045	160	14	EFO_0007986
Disease	non-high density lipoprotein cholesterol measurement	ZNF627 ABCA1 PARP10 THADA ATXN2 FDFT1 DSTYK NCAN SYNE2 SLC17A8 APOL2	1.83e-03	713	160	11	EFO_0005689
Disease	reticulocyte measurement	ABCA1 VWF SIGLEC9 FKBP9 PTPRA WIZ ATXN2 FDFT1 CNTN5 DNAH17 SYNE2 LRP5 RASSF3 SIGLEC1	1.84e-03	1053	160	14	EFO_0010700
Disease	Primary Ciliary Dyskinesia	CCDC39 DNAH5 DNAH9	2.13e-03	47	160	3	C4551720
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	NPHP3 LRP5	2.55e-03	14	160	2	DOID:898 (implicated_via_orthology)
Disease	Kartagener syndrome (implicated_via_orthology)	CCDC39 DNAH5	2.55e-03	14	160	2	DOID:0050144 (implicated_via_orthology)
Disease	waist-hip ratio	PRUNE2 ABCA1 DYNC2H1 SLC6A6 THADA ATXN2 PTPRS ZSCAN30 LOXL1 DSTYK CNTN5 DNAH17 SYNE2 C1QTNF7 ABCC10	2.83e-03	1226	160	15	EFO_0004343
Disease	platelet component distribution width	PRUNE2 VWF ETV5 ST7L ZNF710 CYRIA ATXN2 BAZ2A CNTN5 SIGLEC1 HERC1	2.84e-03	755	160	11	EFO_0007984
Disease	Behcet's syndrome	GAK THADA CNTN5	3.00e-03	53	160	3	EFO_0003780
Disease	non-alcoholic fatty liver disease, cirrhosis of liver	FDFT1 CNTN5 DCLK1	3.00e-03	53	160	3	EFO_0001422, EFO_0003095
Disease	heel bone mineral density, urate measurement	FKBP9 DNAH14 MLKL RNF216 PLCH1	3.21e-03	182	160	5	EFO_0004531, EFO_0009270
Disease	free cholesterol measurement	ABCA1 FNBP4 APOA1 ATXN2	3.39e-03	113	160	4	EFO_0008591
Disease	Cannabis Dependence	FDFT1 APOL2	3.77e-03	17	160	2	C0006870
Disease	phosphatidylcholine 40:6 measurement	PTPRA DNAH9	3.77e-03	17	160	2	EFO_0010389
Disease	sphingomyelin 14:0 measurement	THADA SYNE2	3.77e-03	17	160	2	EFO_0010390
Disease	immature platelet measurement	VWF ST7L BAZ2A RASSF3	4.08e-03	119	160	4	EFO_0803541
Disease	basophil measurement	RAB44 SLC7A8 THADA	4.27e-03	60	160	3	EFO_0803539
Disease	wellbeing measurement	CACNA1E KLHL1 FNBP4 ZKSCAN2 FASN ATXN2 CNTN5 UNC5C RASSF3 HERC1	4.63e-03	692	160	10	EFO_0007869
Disease	cutaneous melanoma, hair color	BCR DSTYK SYNE2	4.68e-03	62	160	3	EFO_0000389, EFO_0003924
Disease	uterine fibroid	KLHL1 ETV1 ZNF208 TGM1 REV1	4.69e-03	199	160	5	EFO_0000731
Disease	body mass index, high density lipoprotein cholesterol measurement	ETV5 ATXN2	4.70e-03	19	160	2	EFO_0004340, EFO_0004612
Disease	bipolar disorder (is_marker_for)	RELN VWF	4.70e-03	19	160	2	DOID:3312 (is_marker_for)
Disease	factor VIII measurement, Ischemic stroke	VWF ATXN2	4.70e-03	19	160	2	EFO_0004630, HP_0002140
Disease	cholesteryl ester measurement, low density lipoprotein cholesterol measurement	ABCA1 APOA1 ATXN2 NCAN	4.99e-03	126	160	4	EFO_0004611, EFO_0010351
Disease	docosahexaenoic acid measurement	ABCA1 HLA-DMA APOA1 NCAN	5.13e-03	127	160	4	EFO_0007761
Disease	myeloid white cell count	PRUNE2 WIPF3 ETV1 ARHGEF12 TEAD1 CYRIA THADA PTPRA ATXN2 DSTYK CNTN5 RASSF3	5.19e-03	937	160	12	EFO_0007988

Protein segments in the cluster

Peptide	Gene	Start	Entry
QNINPGCQEQWEGEE	LINC00114	121	Q6XXX2
DDEAWNGFVAAAELP	APOL2	31	Q9BQE5
QWAEIGFQGDDPKTD	ELMOD2	151	Q8IZ81
EVNSQWENGANLDDP	CTAGE4	296	Q8IX94
EVNSQWENGANLDDP	CTAGE6	296	Q86UF2
EVNSQWENGANLDDP	CTAGE8	296	P0CG41
EVNSQWENGANLDDP	CTAGE15	296	A4D2H0
QDVSFENIQWSIDPG	RBBP8	646	Q99708
DWIGPNDGITQFDNI	CACNA1E	281	Q15878
EVEFPQDDQLQSCGW	CEP19	141	Q96LK0
PNWNEEFEIELEGSQ	BCR	956	P11274
PSQVVDWNAFEDEQK	AFTPH	566	Q6ULP2
FFEERDTPEGLQWVQ	BAZ2A	621	Q9UIF9
WDNLFESPVEEDGFN	ABCA1	806	O95477
TDEFLQWNPEDFDNI	HTR3A	91	P46098
EQLGPVTQEFWDNLE	APOA1	86	P02647
QAQWPGDFAEELATL	CDAN1	1181	Q8IWY9
FKWEENEPTQNQFGE	ARMCX3	316	Q9UH62
RDFSAGQEPDWDNEN	ATP2B3	651	Q16720
AVQQEWAEPDGDLHN	ADAMTS14	211	Q8WXS8
FVEQEEGESKAFQPW	APOBEC2	191	Q9Y235
EGESKAFQPWEDIQE	APOBEC2	196	Q9Y235
EQFENDLETDPPNWQ	ARHGEF12	756	Q9NZN5
WEDGFAIPVANEENK	CCDC39	11	Q9UFE4
VIAWEPVSEEFQNGE	CNTN5	791	O94779
QASEEAKGPWQEADQ	SLC16A2	6	P36021
DSPVWQDQILENEEA	CHM	71	P24386
EVLQEWEAEQDGAPG	RCOR2	381	Q8IZ40
REGQNPVWSEEFVFD	RASA1	631	P20936
DNDDWDQLLSNFGSP	RAB44	366	Q7Z6P3
EIGEWEAFSLPELQN	RASSF3	186	Q86WH2
FEWQDEAPVQVAEGL	GLRA3	201	O75311
QAEFWTDGQTEPAAA	ITPKC	86	Q96DU7
WLEPKNAFENFQEPD	SLC7A8	216	Q9UHI5
AAVQLPSGEDQNDWV	MOB3B	46	Q86TA1
NEGNWFEIQTDPRTN	DSG3	311	P32926
RADEAEAPFAGQNWL	MMP24	71	Q9Y5R2
QAVPKAWAENGQESD	ABCC10	816	Q5T3U5
EALQDQEKAWGFPEN	ELOA2	101	Q8IYF1
DFENAQPTEGEREIW	CYRIA	21	Q9H0Q0
KQVINEGEEPENFFW	FLII	1131	Q13045
NENFSAQGEDEWPPL	LLGL2	476	Q6P1M3
DMADPGQQFQWLEDV	SMPDL3B	206	Q92485
EALENDVSNGWDPND	ATXN2	386	Q99700
WISENQDSADVDPQE	HERC1	1326	Q15751
VNTEINDPDGIAVDW	LRP5	411	O75197
EEEEITINAWFGPQG	KDM8	301	Q8N371
FGQVPDNWREVAVGD	LOXL1	121	Q08397
WVNDDGLPENEHQLS	DCLK1	646	O15075
NWFDIQTDPQTNEGI	DSG4	316	Q86SJ6
LEDQQGGREFWPQEV	FDFT1	221	P37268
FTWPEFLGSNEVNVE	HMGXB3	911	Q12766
PDQWNQETGEEERFA	IL1RAPL1	416	Q9NZN1
AAILQDPGDAEAWQF	PEX5L	351	Q8IYB4
DPGDAEAWQFLGITQ	PEX5L	356	Q8IYB4
TWLAEAQVPDNDEQF	ETV1	56	P50549
EQPGDLFNEDWDSEL	COPRS	106	Q9NQ92
FENDSDALWQRGQVP	MYRFL	401	Q96LU7
NWPGQQLELDEDEAS	PEDS1	6	A5PLL7
GQNWEEQVNSLPEVF	METTL9	266	Q9H1A3
AEWLGSPASFEQERQ	FAM161B	186	Q96MY7
AWLAEAQVPDDEQFV	ETV5	56	P41161
PISQGASWAQEDQQD	MLKL	126	Q8NB16
QGNWETIPEEDLEVQ	DSTYK	181	Q6XUX3
IQEQWSEEFESQPTG	RELN	416	P78509
NKNNWEEQSGNFPEE	PTPRO	236	Q16827
DPGQQFTWEHSNLEV	PTPRS	1401	Q13332
ENPAFWNRQAAEALD	ALPI	26	P09923
DFEDVWEPGGQLSAQ	PCDHAC1	666	Q9H158
ENPDFWNRQAAEALG	ALPG	26	P10696
FIWNGEVSPNLFEEI	FKBP9	486	O95302
NDAWSEFENQGSRPL	GAK	1296	O14976
PELFQENEWDTFTGV	DYNC2H1	3581	Q8NCM8
VGAQAFWLVAEDQDN	CDHR2	41	Q9BYE9
VLEWDQLPVDVQNGF	IL6ST	536	P40189
WENPTQNNAGLEDFE	PRKACB	31	P22694
ENFLFVLGGEDQWNP	KLHL14	371	Q9P2G3
QGEQQEWEGTEELPS	C1QTNF1	31	Q9BXJ1
NGQWATDDIPDDLNS	ADAR	451	P55265
TDDADVATWNNQGLP	DNAH17	3406	Q9UFH2
TAFDPDSTGQQVWQD	GBA2	351	Q9HCG7
NANEFGNSWEEVVPD	FCGBP	1411	Q9Y6R7
GNANEFGNSWEEVVP	FCGBP	2611	Q9Y6R7
FGPEDQRLWNDVTEE	C14orf93	411	Q9H972
IEQFNAEEEAFGWLP	DNAH7	736	Q8WXX0
RLPEFADWAQEQGDA	HLA-DMA	81	P28067
ADWAQEQGDAPAILF	HLA-DMA	86	P28067
DPDNNGFINEDFIVW	TMEM30A	246	Q9NV96
QDDIGFLPEEEWNIF	DNAH14	2836	Q0VDD8
DGVIESNWNEIVDNF	EIF4A2	21	Q14240
EELPFDNVDGGVWRQ	MAN2A2	136	P49641
KVWTANPQQFVEDED	IPO9	376	Q96P70
DIAVEWESSGQPENN	IGHG3	306	P01860
DIAVEWESNGQPENN	IGHG4	256	P01861
DDADVAAWQNEGLPA	DNAH9	3431	Q9NYC9
PKDFWDILNEQNDES	ERCC6L2	1486	Q5T890
GAAGPWFSSEELQEQ	CELSR3	1341	Q9NYQ7
FLEDVQNWELAEEGP	GRK7	86	Q8WTQ7
GKLPESENLQEFWDN	FASN	11	P49327
LRDWFPNTQDLAGND	CEP295	1776	Q9C0D2
DNWLVDTGDSEPQSQ	DPEP1	176	P16444
GQELPLDEQWREAFQ	ATP4A	536	P20648
PEDEVWLEIFFTDQN	C1QTNF7	241	Q9BXJ2
GTASIWNQPQDVVEE	DNAH5	416	Q8TE73
IAAQGPKEETVNDFW	PTPRA	311	P18433
PWNNLERLAENTGEF	PARP10	816	Q53GL7
VLLRPGDFQSQWDED	RAB11FIP1	246	Q6WKZ4
DNQPVLESLGFWEEV	THADA	1476	Q6YHU6
EDPQVWIDAGTQIFF	SLC6A6	286	P31641
EFNWQKEVPSFLQEG	PLCB4	6	Q15147
WESEFGQPELGSNDI	PRUNE2	716	Q8WUY3
NQGWLKGQEEESPFQ	SLC47A2	176	Q86VL8
VQDIVEQDPGQAQEW	SYNE2	3741	Q8WXH0
NEQSGESQWEFPDGE	FNBP4	616	Q8N3X1
LQAEDVAVDGQNWTF	NODAL	61	Q96S42
EAEGQLRFWNPDDLN	NIN	156	Q8N4C6
AQELGPEVSLFNSDW	NXPE3	486	Q969Y0
EGPFANVNRDDWDIA	NPHP3	266	Q7Z494
EFEDVQEQAVWALGN	KPNA1	181	P52294
PWLNDQENTSVEVSG	PKDREJ	916	Q9NTG1
NTGLQFENWRENQPD	NCAN	1161	O14594
WFREGANTDQDAPVA	SIGLEC9	61	Q9Y336
PLDWAEVQSQGEETN	UBA2	281	Q9UBT2
QESQEPNLENIWGQE	RNF216	261	Q9NWF9
PNLENIWGQEAAEVD	RNF216	266	Q9NWF9
AEGVWSPDIEQSFQE	TEAD2	41	Q15562
PWLQAEAVGQSSDDI	WIPF3	456	A6NGB9
FDWLQDEDEQGSPQD	WIZ	136	O95785
NEDGTWLTPNEFEVE	SP110	491	Q9HB58
PEASSEWENQNPAVE	PROB1	431	E7EW31
NEGSFPDWERTNVDA	BRINP2	606	Q9C0B6
RAAPFNNWLDGAVED	ACTN3	531	Q08043
REWEDFSTQPDAQGL	ANGEL1	221	Q9UNK9
NELPELWLGQNEFDF	CITED1	171	Q99966
PVDGWQVVEAQGEDN	NCAPG2	66	Q86XI2
QFGWVSELANQAPET	CLUL1	381	Q15846
IVPQNSNEGWEEEAK	RNF17	581	Q9BXT8
VELFFKDDANNDPQW	PAICS	126	P22234
EGDAQIDPNWVVLNQ	THBS4	741	P35443
ASLFWNAAGEDQEPD	STIL	796	Q15468
QEFWPEQGIEDSFQK	ZNF676	51	Q8N7Q3
LDQDFGLQENPWSQE	ZSCAN30	31	Q86W11
SDLEDVLQVPNGWAN	TSPYL2	671	Q9H2G4
QLPEEGEAESQWLQD	ARHGAP40	56	Q5TG30
NLQVEEDPVDFGNSW	VWF	1011	P04275
SLWENPDSAQANGID	REV1	486	Q9UBZ9
EIDFRCPQDQGWNAE	PHLDA1	261	Q8WV24
RVVDDNGFNPTWEET	PLCH2	806	O75038
AEGVWSPDIEQSFQE	TEAD3	31	Q99594
KPEQGFVWQEASEFE	ZNF710	241	Q8N1W2
ASVGKQWEDQNIEDP	ZNF627	41	Q7L945
QPWASSGFEENTQDL	ST7L	551	Q8TDW4
DFDAQAVNVQVWPGA	SIGLEC1	1081	Q9BZZ2
LQNTNNANGIWEEEP	POLR1F	261	Q3B726
VVDDNGFNPVWEETL	PLCH1	781	Q4KWH8
SEQQEQWEAFVSGPL	PPP6R1	496	Q9UPN7
FAQDIWPEQGVEDSF	ZNF726	81	A6NNF4
FAQDLWPEQGIEDSF	ZNF208	81	O43345
AVDFTQEEWGQLDPT	ZNF8	31	P17098
LGAAWEVADFQPEQV	ZKSCAN2	146	Q63HK3
DFTQEEWGQLDSPQR	ZNF74	51	Q16587
GFDGWQVVDATPQET	TGM1	451	P22735
AEGVWSPDIEQSFQE	TEAD1	31	P28347
DQDEGEWGLDQEQVF	ZBED1	661	O96006
NWVQEQCPENGEEAV	ZSCAN29	76	Q8IWY8
VILDLWEAQNFPDGN	UNC5C	891	O95185
AGRPDQEVAQEAWQN	USP11	431	P51784
LGEDNQPETQLFWDK	TLE6	136	Q9H808
VDGKPEIQTAQFNWD	SLC17A8	111	Q8NDX2
EIQTAQFNWDPETVG	SLC17A8	116	Q8NDX2
PNLDVEQAEVNFGWN	WFS1	386	O76024
GLSAEQQEQWIPEEI	VPS13D	456	Q5THJ4
EGIDPNALWDLVQFA	KLHL1	256	Q9NR64