Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXJ2 MSX2 HOXB6 TCF7L2 NEUROD1 SOX30 SKOR1 GBX2 ZNF683 EVX1 PAX2 BCOR HOXB13 TBX6	8.93e-06	1459	50	14	GO:0000977
GeneOntologyMolecularFunction	transcription factor binding	MSX2 ZNF703 TCF7L2 NEUROD1 GBX2 PAX2 BCL3 BCOR CRTC2 TBX6	1.43e-05	753	50	10	GO:0008134
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXJ2 MSX2 HOXB6 TCF7L2 NEUROD1 SOX30 SKOR1 ZNF683 EVX1 PAX2 HOXB13 TBX6	4.31e-05	1244	50	12	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXJ2 MSX2 HOXB6 TCF7L2 NEUROD1 SOX30 SKOR1 ZNF683 EVX1 PAX2 HOXB13 TBX6	5.31e-05	1271	50	12	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	ZNF703 TCF7L2 NEUROD1 GBX2 BCL3 BCOR CRTC2 TBX6	9.05e-05	582	50	8	GO:0140297
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXJ2 MSX2 HOXB6 TCF7L2 NEUROD1 SOX30 SKOR1 GBX2 EVX1 PAX2 HOXB13 TBX6	1.46e-04	1412	50	12	GO:0000981
GeneOntologyMolecularFunction	Wnt receptor activity	ROR1 PKD1	8.16e-04	17	50	2	GO:0042813
GeneOntologyMolecularFunction	fatty acyl-CoA hydrolase activity	BAAT ACOT4	2.07e-03	27	50	2	GO:0047617
GeneOntologyMolecularFunction	acyl-CoA hydrolase activity	BAAT ACOT4	2.23e-03	28	50	2	GO:0016289
GeneOntologyBiologicalProcess	embryo development	MSX2 HOXB6 TCF7L2 NEUROD1 PKD1 LAMA5 GBX2 EVX1 PAX2 BCOR CPLANE1 CCNK TBX6	1.30e-05	1437	47	13	GO:0009790
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	MSX2 PKD1 LAMA5 GBX2 PAX2 HOXB13	1.53e-05	236	47	6	GO:0061138
GeneOntologyBiologicalProcess	animal organ morphogenesis	MSX2 HOXB6 TCF7L2 NEUROD1 PKD1 LAMA5 GBX2 PAX2 BCOR HOXB13 AGTPBP1 TBX6	1.95e-05	1269	47	12	GO:0009887
GeneOntologyBiologicalProcess	pattern specification process	MSX2 HOXB6 NEUROD1 LAMA5 GBX2 PAX2 BCOR TBX6	2.22e-05	526	47	8	GO:0007389
GeneOntologyBiologicalProcess	morphogenesis of a branching structure	MSX2 PKD1 LAMA5 GBX2 PAX2 HOXB13	2.52e-05	258	47	6	GO:0001763
GeneOntologyBiologicalProcess	embryonic morphogenesis	MSX2 HOXB6 TCF7L2 NEUROD1 LAMA5 GBX2 PAX2 CPLANE1 TBX6	2.81e-05	713	47	9	GO:0048598
GeneOntologyBiologicalProcess	signal transduction involved in regulation of gene expression	MSX2 NEUROD1 TBX6	3.49e-05	28	47	3	GO:0023019
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	FOXJ2 TCF7L2 NEUROD1 SOX30 PKD1 GBX2 EVX1 PAX2 BCL3 CCNK CRTC2 TBX6	4.79e-05	1390	47	12	GO:0045944
GeneOntologyBiologicalProcess	mesenchymal cell differentiation	MSX2 ZNF703 TCF7L2 LAMA5 GBX2 PAX2	5.44e-05	296	47	6	GO:0048762
GeneOntologyBiologicalProcess	regulation of DNA-binding transcription factor activity	MSX2 TCF7L2 NEUROD1 ROR1 BCL3 CRTC2 TBX6	6.55e-05	449	47	7	GO:0051090
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	MSX2 PKD1 LAMA5 GBX2 PAX2 CPLANE1 HOXB13 TBX6	7.03e-05	619	47	8	GO:0002009
GeneOntologyBiologicalProcess	epithelium development	FOXJ2 MSX2 ZNF703 TCF7L2 NEUROD1 PKD1 LAMA5 GBX2 PAX2 CPLANE1 HOXB13 TBX6	8.19e-05	1469	47	12	GO:0060429
GeneOntologyBiologicalProcess	branching morphogenesis of an epithelial tube	MSX2 PKD1 LAMA5 GBX2 PAX2	8.57e-05	198	47	5	GO:0048754
GeneOntologyBiologicalProcess	regionalization	MSX2 HOXB6 NEUROD1 LAMA5 GBX2 PAX2 TBX6	9.69e-05	478	47	7	GO:0003002
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	HOXB6 TCF7L2 NEUROD1 GBX2 PAX2 TBX6	1.39e-04	351	47	6	GO:0048562
GeneOntologyBiologicalProcess	negative regulation of type B pancreatic cell apoptotic process	TCF7L2 NEUROD1	1.41e-04	8	47	2	GO:2000675
GeneOntologyBiologicalProcess	tube morphogenesis	FOXJ2 MSX2 TCF7L2 JMJD8 CSPG4 PKD1 LAMA5 GBX2 PAX2 TBX6	1.83e-04	1125	47	10	GO:0035239
GeneOntologyBiologicalProcess	mesenchyme development	MSX2 ZNF703 TCF7L2 LAMA5 GBX2 PAX2	1.90e-04	372	47	6	GO:0060485
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	HOXB6 TCF7L2 PKD1 GBX2 EVX1 PAX2 BCOR CCNK TBX6	2.14e-04	929	47	9	GO:0009792
GeneOntologyBiologicalProcess	anterior/posterior pattern specification	MSX2 HOXB6 NEUROD1 GBX2 TBX6	2.41e-04	247	47	5	GO:0009952
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	MSX2 ZNF703 TCF7L2 SOX30 SKOR1 PAX2 BCL3 BCOR HOXB13 ZNF503 TBX6	2.41e-04	1399	47	11	GO:0045892
GeneOntologyBiologicalProcess	gland development	MSX2 ZNF703 TCF7L2 BAAT PKD1 LAMA5 HOXB13	2.51e-04	558	47	7	GO:0048732
GeneOntologyBiologicalProcess	embryonic organ development	HOXB6 TCF7L2 NEUROD1 PKD1 GBX2 PAX2 TBX6	2.60e-04	561	47	7	GO:0048568
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	MSX2 ZNF703 TCF7L2 SOX30 SKOR1 PAX2 BCL3 BCOR HOXB13 ZNF503 TBX6	2.63e-04	1413	47	11	GO:1902679
GeneOntologyBiologicalProcess	tissue morphogenesis	MSX2 PKD1 LAMA5 GBX2 PAX2 CPLANE1 HOXB13 TBX6	2.63e-04	750	47	8	GO:0048729
GeneOntologyBiologicalProcess	cerebellum development	NEUROD1 GBX2 CPLANE1 AGTPBP1	2.81e-04	139	47	4	GO:0021549
GeneOntologyBiologicalProcess	neuron development	FRY NEUROD1 ROR1 CSPG4 LAMA5 GBX2 EVX1 PAX2 DCC AGTPBP1 TBX6	3.55e-04	1463	47	11	GO:0048666
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	MSX2 PKD1 LAMA5 GBX2 PAX2 TBX6	3.69e-04	421	47	6	GO:0060562
GeneOntologyBiologicalProcess	odontogenesis	MSX2 TCF7L2 LAMA5 BCOR	3.85e-04	151	47	4	GO:0042476
GeneOntologyBiologicalProcess	mesodermal cell fate specification	PAX2 TBX6	3.90e-04	13	47	2	GO:0007501
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	FOXJ2 MSX2 JMJD8 SOX30 CSPG4 PKD1 GBX2 PAX2 BCL3 AGTPBP1 TBX6	3.99e-04	1483	47	11	GO:0048646
GeneOntologyBiologicalProcess	metencephalon development	NEUROD1 GBX2 CPLANE1 AGTPBP1	4.05e-04	153	47	4	GO:0022037
GeneOntologyBiologicalProcess	regulation of type B pancreatic cell apoptotic process	TCF7L2 NEUROD1	5.24e-04	15	47	2	GO:2000674
GeneOntologyBiologicalProcess	neuron projection development	FRY NEUROD1 ROR1 CSPG4 LAMA5 GBX2 EVX1 PAX2 DCC TBX6	5.29e-04	1285	47	10	GO:0031175
GeneOntologyBiologicalProcess	stem cell differentiation	MSX2 LAMA5 GBX2 PAX2 CCNK	6.41e-04	306	47	5	GO:0048863
GeneOntologyBiologicalProcess	regulation of mesenchymal cell apoptotic process	MSX2 PAX2	6.76e-04	17	47	2	GO:2001053
GeneOntologyBiologicalProcess	type B pancreatic cell apoptotic process	TCF7L2 NEUROD1	7.60e-04	18	47	2	GO:0097050
GeneOntologyBiologicalProcess	mesenchymal cell apoptotic process	MSX2 PAX2	8.48e-04	19	47	2	GO:0097152
GeneOntologyBiologicalProcess	negative regulation of DNA-binding transcription factor activity	MSX2 TCF7L2 BCL3 TBX6	8.78e-04	188	47	4	GO:0043433
GeneOntologyBiologicalProcess	chordate embryonic development	HOXB6 TCF7L2 PKD1 GBX2 PAX2 BCOR CCNK TBX6	9.21e-04	906	47	8	GO:0043009
GeneOntologyBiologicalProcess	tube development	FOXJ2 MSX2 TCF7L2 JMJD8 CSPG4 PKD1 LAMA5 GBX2 PAX2 TBX6	1.04e-03	1402	47	10	GO:0035295
GeneOntologyBiologicalProcess	blood vessel development	FOXJ2 TCF7L2 JMJD8 CSPG4 PKD1 GBX2 CPLANE1 TBX6	1.08e-03	929	47	8	GO:0001568
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	MSX2 ZNF703 TCF7L2 SKOR1 PMEPA1	1.12e-03	347	47	5	GO:0090092
GeneOntologyBiologicalProcess	anatomical structure maturation	MSX2 CSPG4 PAX2 HOXB13 TBX6	1.23e-03	354	47	5	GO:0071695
GeneOntologyBiologicalProcess	mesodermal cell fate commitment	PAX2 TBX6	1.25e-03	23	47	2	GO:0001710
GeneOntologyBiologicalProcess	hindbrain development	NEUROD1 GBX2 CPLANE1 AGTPBP1	1.28e-03	208	47	4	GO:0030902
GeneOntologyBiologicalProcess	circulatory system development	FOXJ2 MSX2 TCF7L2 JMJD8 CSPG4 PKD1 GBX2 BCOR CPLANE1 TBX6	1.29e-03	1442	47	10	GO:0072359
GeneOntologyBiologicalProcess	vasculature development	FOXJ2 TCF7L2 JMJD8 CSPG4 PKD1 GBX2 CPLANE1 TBX6	1.42e-03	969	47	8	GO:0001944
GeneOntologyBiologicalProcess	central nervous system neuron development	GBX2 DCC AGTPBP1	1.49e-03	99	47	3	GO:0021954
MousePheno	decreased cochlea coiling	ROR1 GBX2 PAX2	1.55e-05	17	41	3	MP:0003148
MousePheno	abnormal primary cilium morphology	CEP78 PKD1 CPLANE1 AGTPBP1 TBX6	1.96e-05	114	41	5	MP:0013203
MousePheno	abnormal nonmotile primary cilium morphology	CEP78 PKD1 CPLANE1 AGTPBP1	5.08e-05	70	41	4	MP:0013205
MousePheno	double outlet right ventricle	TCF7L2 PKD1 LAMA5 GBX2 CPLANE1	7.30e-05	150	41	5	MP:0000284
MousePheno	absent cochlear ganglion	GBX2 PAX2	8.35e-05	5	41	2	MP:0003146
MousePheno	abnormal pancreatic islet number	NEUROD1 PKD1 PAX2	9.00e-05	30	41	3	MP:0009166
MousePheno	ventricular septal defect	TCF7L2 CYP51A1 PKD1 LAMA5 GBX2 CPLANE1	1.04e-04	261	41	6	MP:0010402
MousePheno	abnormal intestinal enteroendocrine cell morphology	TCF7L2 NEUROD1	1.25e-04	6	41	2	MP:0010802
MousePheno	kidney cyst	PKD1 LAMA5 PAX2 CPLANE1 TBX6	1.59e-04	177	41	5	MP:0003675
MousePheno	absent vestibular saccule	GBX2 PAX2	1.75e-04	7	41	2	MP:0004315
MousePheno	perinatal lethality, complete penetrance	CACNB1 TCF7L2 NEUROD1 ROR1 PKD1 GBX2 PAX2 DCC ZNF503	1.77e-04	712	41	9	MP:0011089
MousePheno	abnormal forebrain morphology	ATXN2L TCF7L2 NEUROD1 CSPG4 PKD1 GBX2 PAX2 DCC BCOR AGTPBP1 ZNF503	1.90e-04	1072	41	11	MP:0000783
MousePheno	abnormal metencephalon morphology	MSX2 NEUROD1 GBX2 PAX2 DCC CPLANE1 AGTPBP1	1.95e-04	420	41	7	MP:0000847
MousePheno	abnormal cyst	PKD1 LAMA5 GBX2 PAX2 CPLANE1 TBX6	1.99e-04	294	41	6	MP:0031310
MousePheno	abnormal right subclavian artery morphology	TCF7L2 LAMA5 GBX2	2.15e-04	40	41	3	MP:0010487
MousePheno	abnormal innervation	ROR1 GBX2 PAX2 DCC HOXB13	2.38e-04	193	41	5	MP:0002184
MousePheno	abnormal heart and great artery attachment	TCF7L2 PKD1 LAMA5 GBX2 CPLANE1	3.15e-04	205	41	5	MP:0010426
MousePheno	kidney failure	PKD1 LAMA5 PAX2	3.26e-04	46	41	3	MP:0003606
MousePheno	abnormal heart and great vessel attachment	TCF7L2 PKD1 LAMA5 GBX2 CPLANE1	3.37e-04	208	41	5	MP:0010425
MousePheno	abnormal pons morphology	GBX2 DCC AGTPBP1	3.93e-04	49	41	3	MP:0000848
MousePheno	abnormal aortic arch morphology	TCF7L2 LAMA5 GBX2 CPLANE1	3.96e-04	119	41	4	MP:0004113
MousePheno	abnormal interventricular septum morphology	TCF7L2 CYP51A1 PKD1 LAMA5 GBX2 CPLANE1	4.48e-04	342	41	6	MP:0000281
MousePheno	abnormal photoreceptor connecting cilium morphology	CEP78 AGTPBP1	4.54e-04	11	41	2	MP:0014059
MousePheno	absent cerebellum	GBX2 PAX2	4.54e-04	11	41	2	MP:0000850
MousePheno	abnormal optic nerve innervation	PAX2 DCC	4.54e-04	11	41	2	MP:0001332
MousePheno	abnormal common crus morphology	GBX2 PAX2	4.54e-04	11	41	2	MP:0004922
MousePheno	pulmonary artery hypoplasia	LAMA5 CPLANE1	4.54e-04	11	41	2	MP:0010460
MousePheno	abnormal hindbrain morphology	MSX2 NEUROD1 GBX2 PAX2 DCC CPLANE1 AGTPBP1	4.68e-04	485	41	7	MP:0000841
MousePheno	abnormal aorta morphology	TCF7L2 PKD1 LAMA5 GBX2 CPLANE1	4.83e-04	225	41	5	MP:0000272
MousePheno	absent kidney	TCF7L2 LAMA5 PAX2	4.95e-04	53	41	3	MP:0000520
MousePheno	abnormal subclavian artery morphology	TCF7L2 LAMA5 GBX2	5.83e-04	56	41	3	MP:0003395
MousePheno	abnormal retina layer morphology	MSX2 NEUROD1 CEP78 SOX30 PAX2 DCC AGTPBP1	5.89e-04	504	41	7	MP:0003727
MousePheno	abnormal somatic nervous system morphology	HOXB6 NEUROD1 CEP78 ROR1 GBX2 PAX2 DCC HOXB13 AGTPBP1 ZNF503	5.93e-04	1025	41	10	MP:0002752
MousePheno	abnormal cardiac outflow tract development	TCF7L2 PKD1 LAMA5 CPLANE1	6.21e-04	134	41	4	MP:0006126
MousePheno	abnormal thoracic aorta morphology	TCF7L2 LAMA5 GBX2 CPLANE1	6.21e-04	134	41	4	MP:0010468
MousePheno	right aortic arch	LAMA5 GBX2 CPLANE1	7.14e-04	60	41	3	MP:0004158
MousePheno	abnormal enteroendocrine cell morphology	TCF7L2 NEUROD1	7.47e-04	14	41	2	MP:0004141
MousePheno	kidney medulla cyst	PKD1 PAX2	7.47e-04	14	41	2	MP:0011307
MousePheno	abnormal nervous system development	MSX2 NEUROD1 ROR1 PKD1 LAMA5 GBX2 PAX2 DCC BCOR HOXB13 TBX6	7.48e-04	1257	41	11	MP:0003861
MousePheno	neonatal lethality, complete penetrance	TCF7L2 ROR1 PKD1 GBX2 PAX2 DCC ZNF503	8.29e-04	534	41	7	MP:0011087
MousePheno	abnormal somatic sensory system morphology	NEUROD1 CEP78 ROR1 GBX2 PAX2 DCC HOXB13 AGTPBP1	8.50e-04	702	41	8	MP:0000959
MousePheno	abnormal midbrain-hindbrain boundary morphology	GBX2 PAX2	8.60e-04	15	41	2	MP:0012132
MousePheno	abnormal heart septum morphology	TCF7L2 CYP51A1 PKD1 LAMA5 GBX2 CPLANE1	8.69e-04	388	41	6	MP:0006113
MousePheno	abnormal cerebellum morphology	MSX2 NEUROD1 GBX2 PAX2 CPLANE1 AGTPBP1	8.81e-04	389	41	6	MP:0000849
MousePheno	micrognathia	CYP51A1 PKD1 CPLANE1	1.03e-03	68	41	3	MP:0002639
MousePheno	abnormal neurocranium morphology	MSX2 TCF7L2 PKD1 LAMA5 GBX2	1.08e-03	269	41	5	MP:0000074
MousePheno	abnormal embryonic tissue morphology	TCF7L2 POLD1 PKD1 LAMA5 GBX2 EVX1 PAX2 BCOR HOXB13 TBX6	1.15e-03	1116	41	10	MP:0002085
MousePheno	chondrodystrophy	MSX2 PKD1	1.25e-03	18	41	2	MP:0002657
Domain	Tscrpt_rep_NocA-like	ZNF703 ZNF503	6.74e-06	2	49	2	IPR022129
Domain	nlz1	ZNF703 ZNF503	6.74e-06	2	49	2	PF12402
Domain	Bile_Hydr_Trans	BAAT ACOT4	4.03e-05	4	49	2	PF04775
Domain	Thio_Ohase/aa_AcTrfase	BAAT ACOT4	4.03e-05	4	49	2	IPR006862
Domain	Acyl-CoA_thioEstase_long-chain	BAAT ACOT4	4.03e-05	4	49	2	IPR016662
Domain	BAAT_C	BAAT ACOT4	6.71e-05	5	49	2	IPR014940
Domain	BAAT_C	BAAT ACOT4	6.71e-05	5	49	2	PF08840
Domain	Homeobox_metazoa	MSX2 HOXB6 GBX2 EVX1	9.05e-05	90	49	4	IPR020479
Domain	-	MSX2 HOXB6 GBX2 EVX1 PAX2 HOXB13	9.29e-05	283	49	6	1.10.10.60
Domain	Homeobox_CS	MSX2 HOXB6 GBX2 EVX1 HOXB13	1.24e-04	186	49	5	IPR017970
Domain	Homeodomain-like	MSX2 HOXB6 GBX2 EVX1 PAX2 HOXB13	2.21e-04	332	49	6	IPR009057
Domain	Homeobox	MSX2 HOXB6 GBX2 EVX1 HOXB13	3.60e-04	234	49	5	PF00046
Domain	HOMEOBOX_1	MSX2 HOXB6 GBX2 EVX1 HOXB13	3.74e-04	236	49	5	PS00027
Domain	HOX	MSX2 HOXB6 GBX2 EVX1 HOXB13	3.82e-04	237	49	5	SM00389
Domain	Homeobox_dom	MSX2 HOXB6 GBX2 EVX1 HOXB13	3.97e-04	239	49	5	IPR001356
Domain	HOMEOBOX_2	MSX2 HOXB6 GBX2 EVX1 HOXB13	3.97e-04	239	49	5	PS50071
Domain	LAM_G_DOMAIN	CSPG4 LAMA5	4.46e-03	38	49	2	PS50025
Domain	Laminin_G_2	CSPG4 LAMA5	4.94e-03	40	49	2	PF02210
Domain	LamG	CSPG4 LAMA5	5.95e-03	44	49	2	SM00282
Domain	HMG_box	TCF7L2 SOX30	8.53e-03	53	49	2	PF00505
Domain	HMG_BOX_2	TCF7L2 SOX30	8.85e-03	54	49	2	PS50118
Domain	HMG	TCF7L2 SOX30	8.85e-03	54	49	2	SM00398
Domain	-	TCF7L2 SOX30	9.16e-03	55	49	2	1.10.30.10
Domain	Laminin_G	CSPG4 LAMA5	1.02e-02	58	49	2	IPR001791
Pathway	REACTOME_GASTRULATION	TCF7L2 GBX2 PAX2 TBX6	2.23e-04	129	33	4	M46433
Pathway	REACTOME_FORMATION_OF_THE_POSTERIOR_NEURAL_PLATE	GBX2 TBX6	2.36e-04	10	33	2	M48036
Pathway	WP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION	MSX2 CSPG4 EVX1 FUT4	2.43e-04	132	33	4	M48110
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXJ2 MSX2 HOXB6 NEUROD1 SOX30 SKOR1 GBX2 EVX1 PAX2 HOXB13 TBX6	2.67e-10	544	50	11	28473536
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXJ2 MSX2 HOXB6 TCF7L2 NEUROD1 SOX30 SKOR1 GBX2 EVX1 PAX2 HOXB13 TBX6	4.55e-09	908	50	12	19274049
Pubmed	Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development.	TCF7L2 GBX2 PAX2	9.75e-08	7	50	3	17366625
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	FOXJ2 MSX2 HOXB6 TCF7L2 GBX2 PAX2 HOXB13	9.88e-08	263	50	7	20932939
Pubmed	DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function.	EVX1 PAX2 DCC	1.56e-07	8	50	3	22521513
Pubmed	Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development.	TCF7L2 GBX2 PAX2	4.58e-07	11	50	3	21246658
Pubmed	Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors.	ZNF703 GBX2 ZNF503	6.09e-07	12	50	3	27793834
Pubmed	Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development.	NEUROD1 GBX2 PAX2	7.92e-07	13	50	3	15652707
Pubmed	Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear.	NEUROD1 GBX2 PAX2	1.01e-06	14	50	3	19540218
Pubmed	The lineage contribution and role of Gbx2 in spinal cord development.	GBX2 EVX1 PAX2	1.26e-06	15	50	3	21698205
Pubmed	Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis.	NEUROD1 GBX2 PAX2	1.55e-06	16	50	3	30504125
Pubmed	The role of Pax2 in mouse inner ear development.	NEUROD1 GBX2 PAX2	1.87e-06	17	50	3	15242798
Pubmed	Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus.	MSX2 GBX2 PAX2	1.87e-06	17	50	3	16900517
Pubmed	Increased β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics.	TCF7L2 GBX2 PAX2	1.87e-06	17	50	3	22102609
Pubmed	Requirement of TCF7L2 for TGF-beta-dependent transcriptional activation of the TMEPAI gene.	TCF7L2 PMEPA1	2.03e-06	2	50	2	20889500
Pubmed	Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease.	PKD1 PAX2	2.03e-06	2	50	2	17082250
Pubmed	Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.	ATXN2L TCF7L2 CEP78	2.25e-06	18	50	3	28689657
Pubmed	Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation.	GBX2 EVX1 TBX6	2.25e-06	18	50	3	17507393
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ATXN2L CACNB1 KIAA1549L BCOR PMEPA1 PRRC2A CCNK AGTPBP1	2.34e-06	608	50	8	16713569
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ATXN2L ZNF703 BCOR CCNK ZNF503	2.70e-06	152	50	5	38360978
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MSX2 TNRC18 CSPG4 PKD1 LAMA5 GBX2 PAX2 HOXB13 PLEKHH3 ZNF503	3.26e-06	1105	50	10	35748872
Pubmed	Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.	GBX2 EVX1 TBX6	3.65e-06	21	50	3	10421635
Pubmed	Specification of the mammalian cochlea is dependent on Sonic hedgehog.	NEUROD1 GBX2 PAX2	4.22e-06	22	50	3	12231626
Pubmed	A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.	GBX2 EVX1 TBX6	4.22e-06	22	50	3	10021340
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	ATXN2L FRY FAM120A POLD1 OTUD4 PRRC2A PLEKHH3	4.25e-06	462	50	7	31138677
Pubmed	Emx2 directs the development of diencephalon in cooperation with Otx2.	TCF7L2 GBX2 PAX2	5.54e-06	24	50	3	11493561
Pubmed	The copy number variation landscape of congenital anomalies of the kidney and urinary tract.	PAX2 TBX6	6.07e-06	3	50	2	30578417
Pubmed	Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1-/- mutant mouse embryos: an investigation of the feasibility of renal cyst prevention in the foetus.	PKD1 PAX2	6.07e-06	3	50	2	22725947
Pubmed	Wnt signals mediate a fate decision between otic placode and epidermis.	NEUROD1 GBX2 PAX2	6.29e-06	25	50	3	16452098
Pubmed	Redundant functions of Rac GTPases in inner ear morphogenesis.	NEUROD1 GBX2 PAX2	7.10e-06	26	50	3	22182523
Pubmed	Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2.	GBX2 EVX1 PAX2	7.98e-06	27	50	3	21925604
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	MSX2 TCF7L2 SKOR1 GBX2 HOXB13	8.22e-06	191	50	5	24146773
Pubmed	Identification of Arx transcriptional targets in the developing basal forebrain.	SKOR1 GBX2 ZNF503	8.93e-06	28	50	3	18799476
Pubmed	The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution.	MSX2 ROR1	1.21e-05	4	50	2	12754255
Pubmed	Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation.	ROR1 PAX2	1.21e-05	4	50	2	26840931
Pubmed	LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1.	PAX2 FUT4	1.21e-05	4	50	2	16458284
Pubmed	Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear.	NEUROD1 PAX2	1.21e-05	4	50	2	11793341
Pubmed	GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear.	NEUROD1 PAX2	1.21e-05	4	50	2	15003631
Pubmed	BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary.	LAMA5 GBX2	1.21e-05	4	50	2	11863370
Pubmed	Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice.	PKD1 PAX2	1.21e-05	4	50	2	22835934
Pubmed	The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration.	GBX2 PAX2 DCC	1.22e-05	31	50	3	30470704
Pubmed	Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.	EVX1 PAX2 DCC	1.35e-05	32	50	3	26758845
Pubmed	Abnormalities in neural crest cell migration in laminin alpha5 mutant mice.	NEUROD1 LAMA5	2.02e-05	5	50	2	16316641
Pubmed	Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.	PAX2 DCC	2.02e-05	5	50	2	9331350
Pubmed	Impaired intermediate formation in mouse embryos expressing reduced levels of Tbx6.	PAX2 TBX6	2.02e-05	5	50	2	30548789
Pubmed	Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.	ZNF703 ZNF503	2.02e-05	5	50	2	25640223
Pubmed	Gbx1 and Gbx2 Are Essential for Normal Patterning and Development of Interneurons and Motor Neurons in the Embryonic Spinal Cord.	GBX2 PAX2	2.02e-05	5	50	2	32244588
Pubmed	Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.	TCF7L2 GBX2 ZNF503	2.66e-05	40	50	3	27657450
Pubmed	Serotonin modulates the response of embryonic thalamocortical axons to netrin-1.	GBX2 DCC	3.03e-05	6	50	2	17450135
Pubmed	PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development.	EVX1 PAX2	3.03e-05	6	50	2	9409667
Pubmed	Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice.	CSPG4 PAX2	3.03e-05	6	50	2	12809690
Pubmed	Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.	PKD1 PAX2	4.23e-05	7	50	2	29107072
Pubmed	Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear.	NEUROD1 PAX2	4.23e-05	7	50	2	15329890
Pubmed	Region- and cell type-selective expression of the evolutionarily conserved Nolz-1/zfp503 gene in the developing mouse hindbrain.	PAX2 ZNF503	4.23e-05	7	50	2	21945624
Pubmed	FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.	GBX2 DCC	4.23e-05	7	50	2	24560577
Pubmed	Wnt signaling mediates regional specification in the vertebrate face.	MSX2 TCF7L2	5.64e-05	8	50	2	17699607
Pubmed	Revisiting the role of Dcc in visual system development with a novel eye clearing method.	PAX2 DCC	5.64e-05	8	50	2	32096760
Pubmed	DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans.	PAX2 DCC	5.64e-05	8	50	2	29386099
Pubmed	Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8.	GBX2 PAX2	5.64e-05	8	50	2	11704761
Pubmed	Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.	EVX1 PAX2	5.64e-05	8	50	2	23816521
Pubmed	Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation.	HOXB6 EVX1	5.64e-05	8	50	2	18562676
Pubmed	Expression of mouse Foxi class genes in early craniofacial development.	NEUROD1 PAX2	5.64e-05	8	50	2	15376323
Pubmed	Dual-mode operation of neuronal networks involved in left-right alternation.	EVX1 PAX2	5.64e-05	8	50	2	23812590
Pubmed	Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.	FRY PKD1	5.64e-05	8	50	2	25907116
Pubmed	OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.	GBX2 PAX2	5.64e-05	8	50	2	12915318
Pubmed	Msx genes delineate a novel molecular map of the developing cerebellar neuroepithelium.	MSX2 PAX2	5.64e-05	8	50	2	38742226
Pubmed	Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.	MSX2 PAX2	5.64e-05	8	50	2	9501086
Pubmed	Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.	GBX2 DCC	5.64e-05	8	50	2	18479186
Pubmed	The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes.	GBX2 PAX2	7.25e-05	9	50	2	25178196
Pubmed	The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse.	EVX1 FUT4	7.25e-05	9	50	2	15750184
Pubmed	Tissue-specific requirements for FGF8 during early inner ear development.	NEUROD1 PAX2	7.25e-05	9	50	2	19619645
Pubmed	Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm.	CSPG4 PAX2	7.25e-05	9	50	2	31731293
Pubmed	Msx1 is expressed in retina endothelial cells at artery branching sites.	MSX2 CSPG4	7.25e-05	9	50	2	23213427
Pubmed	Msx1 and Msx2 are expressed in sub-populations of vascular smooth muscle cells.	MSX2 CSPG4	7.25e-05	9	50	2	18627106
Pubmed	FGF8 initiates inner ear induction in chick and mouse.	GBX2 PAX2	7.25e-05	9	50	2	15741321
Pubmed	Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud.	MSX2 EVX1	7.25e-05	9	50	2	7588050
Pubmed	Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord.	EVX1 PAX2	7.25e-05	9	50	2	9858722
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ATXN2L ZNF703 FAM120A CEP78 OTUD4 PRRC2A AGTPBP1	7.55e-05	724	50	7	36232890
Pubmed	Origins and control of the differentiation of inhibitory interneurons and glia in the cerebellum.	CSPG4 PAX2	9.05e-05	10	50	2	19217896
Pubmed	V1 spinal neurons regulate the speed of vertebrate locomotor outputs.	EVX1 PAX2	9.05e-05	10	50	2	16525473
Pubmed	Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.	GBX2 PAX2	9.05e-05	10	50	2	11731459
Pubmed	Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia.	TCF7L2 PAX2	9.05e-05	10	50	2	33735101
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	ATXN2L TCF7L2 FAM120A OTUD4 PRRC2A	9.79e-05	321	50	5	32098917
Pubmed	Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.	SKOR1 PAX2	1.10e-04	11	50	2	19141316
Pubmed	The homeobox containing gene Lbx1 is required for correct dorsal-ventral patterning of the neural tube.	MSX2 EVX1	1.10e-04	11	50	2	12358782
Pubmed	Vax genes ventralize the embryonic eye.	NEUROD1 PAX2	1.10e-04	11	50	2	15905411
Pubmed	Msx1 is required for dorsal diencephalon patterning.	MSX2 GBX2	1.10e-04	11	50	2	12874124
Pubmed	Suppression of neural fate and control of inner ear morphogenesis by Tbx1.	NEUROD1 PAX2	1.10e-04	11	50	2	15084464
Pubmed	Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord.	PAX2 DCC	1.10e-04	11	50	2	15788454
Pubmed	Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure.	PAX2 ZNF503	1.10e-04	11	50	2	36326727
Pubmed	Role of Pax6 in development of the cerebellar system.	PAX2 DCC	1.10e-04	11	50	2	10409504
Pubmed	Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.	TCF7L2 GBX2	1.10e-04	11	50	2	15201223
Pubmed	Fgf3 and Fgf10 are required for mouse otic placode induction.	GBX2 PAX2	1.10e-04	11	50	2	12810586
Pubmed	Commissural axonal corridors instruct neuronal migration in the mouse spinal cord.	EVX1 DCC	1.10e-04	11	50	2	25960414
Pubmed	Pax2/5 and Pax6 subdivide the early neural tube into three domains.	GBX2 PAX2	1.10e-04	11	50	2	10354469
Pubmed	A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations.	HOXB6 HOXB13	1.10e-04	11	50	2	10885747
Pubmed	Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.	NEUROD1 GBX2 PAX2	1.15e-04	65	50	3	33795231
Pubmed	Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer.	GBX2 PAX2	1.32e-04	12	50	2	16530751
Pubmed	Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.	GBX2 PAX2	1.32e-04	12	50	2	9486536
Pubmed	A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.	POLD1 TBX6	1.32e-04	12	50	2	35876795
Interaction	TLE3 interactions	FOXJ2 ZNF703 TNRC18 TCF7L2 OTUD4 PAX2 BCOR CRTC2 ZNF503	2.65e-07	376	49	9	int:TLE3
Interaction	ALG13 interactions	ZNF703 TCF7L2 FAM120A OTUD4 BCOR PRRC2A CCNK	2.83e-07	183	49	7	int:ALG13
Interaction	CLEC11A interactions	TCF7L2 CEP78 OTUD4 BCOR PLEKHH3	3.57e-06	96	49	5	int:CLEC11A
Interaction	PRR20E interactions	TCF7L2 ZNF683 BCOR CCNK TBX6	4.58e-06	101	49	5	int:PRR20E
Interaction	EYA4 interactions	FOXJ2 ATXN2L ZNF703 BCOR CCNK ZNF503	2.62e-05	243	49	6	int:EYA4
Interaction	TOP3B interactions	MSX2 TNRC18 FAM120A CSPG4 PKD1 OTUD4 LAMA5 GBX2 PAX2 PRRC2A HOXB13 PLEKHH3 ZNF503	3.44e-05	1470	49	13	int:TOP3B
Interaction	DLX5 interactions	FOXJ2 MSX2 HOXB13	4.72e-05	29	49	3	int:DLX5
Interaction	PRDM1 interactions	ZNF703 TCF7L2 BCOR ZNF503	5.16e-05	84	49	4	int:PRDM1
Interaction	GSC interactions	ZNF703 TNRC18 TCF7L2 ZNF503	5.92e-05	87	49	4	int:GSC
Interaction	PRR20B interactions	TCF7L2 ZNF683 CCNK TBX6	6.76e-05	90	49	4	int:PRR20B
Interaction	PRR20C interactions	TCF7L2 ZNF683 CCNK TBX6	6.76e-05	90	49	4	int:PRR20C
Interaction	PRR20D interactions	TCF7L2 ZNF683 CCNK TBX6	6.76e-05	90	49	4	int:PRR20D
Interaction	FOXI1 interactions	ZNF703 TCF7L2 BCOR ZNF503	7.36e-05	92	49	4	int:FOXI1
Interaction	KRTAP6-2 interactions	TCF7L2 ZNF683 CCNK ZNF503 TBX6	8.93e-05	187	49	5	int:KRTAP6-2
Interaction	GATA2 interactions	MSX2 ZNF703 TCF7L2 BCOR ZNF503	1.20e-04	199	49	5	int:GATA2
Interaction	PRR20A interactions	TCF7L2 ZNF683 CCNK TBX6	1.42e-04	109	49	4	int:PRR20A
Interaction	TBR1 interactions	ZNF703 TCF7L2 BCOR ZNF503	1.63e-04	113	49	4	int:TBR1
Interaction	PAX7 interactions	ZNF703 TCF7L2 BCOR ZNF503	2.34e-04	124	49	4	int:PAX7
Interaction	HSFY2 interactions	CCNK TBX6	3.14e-04	11	49	2	int:HSFY2
GeneFamily	HOXL subclass homeoboxes	HOXB6 GBX2 EVX1 HOXB13	2.06e-06	52	32	4	518
Coexpression	CYCLIN_D1_UP.V1_UP	KIAA1549L PKD1 EVX1 PAX2 PRRC2A HOXB13	1.49e-06	187	50	6	M2654
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	GJA3 HOXB6 GBX2 EVX1 PAX2 BCL3	1.28e-05	272	50	6	M1938
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	GJA3 HOXB6 GBX2 EVX1 PAX2 BCL3	1.57e-05	282	50	6	MM822
Coexpression	IBRAHIM_NRF1_DOWN	CACNB1 HOXB6 TNRC18 BCOR PLEKHH3	1.66e-05	167	50	5	M42512
Coexpression	BENPORATH_EED_TARGETS	MSX2 HOXB6 NEUROD1 GBX2 EVX1 PAX2 FUT4 DCC HOXB13 ZNF503	2.62e-05	1059	50	10	M7617
Coexpression	NUYTTEN_NIPP1_TARGETS_DN	TCF7L2 FAM120A ROR1 LAMA5 GBX2 SLC43A3 FUT4 HOXB13 ZNF503	2.76e-05	845	50	9	M18090
Coexpression	BENPORATH_PRC2_TARGETS	HOXB6 NEUROD1 GBX2 PAX2 FUT4 DCC HOXB13 ZNF503	2.93e-05	650	50	8	M8448
Coexpression	GSE22045_TREG_VS_TCONV_DN	TCF7L2 JMJD8 CPLANE1 PMEPA1 CCNK	3.17e-05	191	50	5	M4401
Coexpression	BENPORATH_ES_WITH_H3K27ME3	MSX2 HOXB6 NEUROD1 GBX2 EVX1 PAX2 FUT4 DCC HOXB13 ZNF503	4.05e-05	1115	50	10	M10371
Coexpression	FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN	TPMT TNRC18 OTUD4 EVX1 PROB1 CPLANE1 AGTPBP1 PRR27	7.74e-05	746	50	8	M40863
Coexpression	TABULA_MURIS_SENIS_BROWN_ADIPOSE_TISSUE_MYELOID_CELL_AGEING	ATXN2L ZNF703 TCF7L2 SLC43A3 PRRC2A	9.35e-05	240	50	5	MM3678
Coexpression	BENPORATH_SUZ12_TARGETS	ZNF703 HOXB6 NEUROD1 GBX2 PAX2 FUT4 DCC HOXB13 ZNF503	1.31e-04	1035	50	9	M9898
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF703 TCF7L2 SKOR1 ACOT4 IGFLR1	1.06e-06	162	50	5	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATXN2L ZNF703 BCL3 PMEPA1 PRRC2A	2.08e-06	186	50	5	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATXN2L ZNF703 BCL3 PMEPA1 PRRC2A	2.25e-06	189	50	5	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	Cerebellum\|World / BrainAtlas - Mouse McCarroll V32	MSX2 NEUROD1 SKOR1 PAX2	2.24e-05	147	50	4	dd730224e39571ca2c35042e242a908a02ee377d
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF703 TCF7L2 ACOT4 IGFLR1	2.97e-05	158	50	4	6811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FRY ACOT4 DCC ZNF503	3.36e-05	163	50	4	0ab043b68e8739adcedda01165a3758cd0d22728
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GJA3 BAAT GBX2	4.23e-05	60	50	3	aa75fef294803ec6396c7d2c1f51d52bc4a5b43f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GJA3 BAAT GBX2	4.23e-05	60	50	3	069fbabfd0e48e5809ff01a026439fd0bd017779
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-2\|TCGA-Colorectal / Sample_Type by Project: Shred V9	GJA3 KIAA1549L ZNF683 SLC43A3	4.53e-05	176	50	4	1870860a9ebe7a655c4ea8898427e1097ee23113
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HOXB6 CEP78 OTUD4 PMEPA1	6.22e-05	191	50	4	cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRY CSPG4 PMEPA1 PLEKHH3	6.22e-05	191	50	4	239c1e68eb1cbe3e137a99fbd6eeb8d64c919ffd
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ROR1 BAAT LAMA5 PMEPA1	6.74e-05	195	50	4	b65511770ed67f7447847e2187555b362988af45
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ROR1 BAAT LAMA5 PMEPA1	6.74e-05	195	50	4	07a3ef6b0f1201fe2bcb9ea426b8f7a69beb4904
ToppCell	(7)_Epithelial-I_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ROR1 BAAT LAMA5 PMEPA1	6.88e-05	196	50	4	150554fa06868d29b0608189862eef6505ba757f
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ROR1 BAAT LAMA5 PMEPA1	7.01e-05	197	50	4	69d5b8588046d119b5dff9a7fd6f49e97e00a5b7
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ROR1 BAAT LAMA5 PMEPA1	7.01e-05	197	50	4	e6cbfa267eb2e05b441fd034786faae07bb0e081
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	ROR1 BAAT LAMA5 PMEPA1	7.29e-05	199	50	4	5a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Glia_progenitor_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	TCF7L2 CSPG4 PPP1R3F PMEPA1	7.44e-05	200	50	4	4b937b1d0179d1d0e51931f35720e205d460a07e
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SOX30 BAAT DCC	8.91e-05	77	50	3	a799ccdb84014e978d9fbccf3d2fee8fbeac7b0c
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GJA3 SOX30 GBX2	9.62e-05	79	50	3	03c5af851b53800eced1c74e9da374c71092bcd4
Drug	BM-1	CYP51A1 BCL3 FUT4 PRRC2A	1.34e-05	66	50	4	CID000159986
Drug	lomustine; Down 200; 100uM; PC3; HT_HG-U133A	TPMT TCF7L2 GBX2 PMEPA1 HOXB13	5.70e-05	188	50	5	7050_DN
Drug	Propantheline bromide [50-34-0]; Up 200; 9uM; MCF7; HT_HG-U133A	TPMT CACNB1 HOXB6 SOX30 PAX2	6.62e-05	194	50	5	4798_UP
Drug	Bromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A	ATXN2L CSPG4 BAAT CPLANE1 TBX6	6.78e-05	195	50	5	5665_UP
Drug	rofecoxib; Up 200; 10uM; MCF7; HG-U133A	ATXN2L TCF7L2 PAX2 IGFLR1 PRRC2A	6.78e-05	195	50	5	166_UP
Drug	MoCl3	NEUROD1 BCL3	7.05e-05	6	50	2	CID000083515
Drug	clofibroyl-CoA	BAAT ACOT4	7.05e-05	6	50	2	CID000175978
Drug	AC1L2KCZ	BAAT ACOT4	7.05e-05	6	50	2	CID000022414
Drug	Ebselen [60940-34-3]; Down 200; 14.6uM; PC3; HT_HG-U133A	TPMT MSX2 KIAA1549L SLC43A3 IGFLR1	7.12e-05	197	50	5	5778_DN
Drug	Clozapine [5786-21-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A	TPMT ATXN2L CACNB1 PAX2 DCC	7.12e-05	197	50	5	5630_UP
Drug	N-phenylanthranilic acid; Up 200; 10uM; MCF7; HG-U133A	TPMT ATXN2L TCF7L2 PAX2 CCNK	7.29e-05	198	50	5	317_UP
Drug	Arcaine sulfate [14923-17-2]; Up 200; 14.8uM; HL60; HT_HG-U133A	ATXN2L ROR1 CSPG4 PAX2 CCNK	7.29e-05	198	50	5	3010_UP
Drug	Ethoxyquin [91-53-2]; Up 200; 18.4uM; PC3; HT_HG-U133A	ATXN2L CACNB1 KIAA1549L ROR1 CCNK	7.47e-05	199	50	5	3764_UP
Drug	Suramin sodium salt; Up 200; 10uM; PC3; HT_HG-U133A	HOXB6 TCF7L2 OTUD4 SLC43A3 FUT4	7.65e-05	200	50	5	7501_UP
Drug	Carbenoxolone disodium salt [7421-40-1]; Up 200; 6.6uM; MCF7; HT_HG-U133A	HOXB6 CSPG4 SLC43A3 FUT4 TBX6	7.65e-05	200	50	5	4173_UP
Drug	ReCl5	NEUROD1 BCL3	9.86e-05	7	50	2	CID000083602
Drug	WCl5	NEUROD1 BCL3	9.86e-05	7	50	2	CID000139469
Drug	TaCl5	NEUROD1 BCL3	9.86e-05	7	50	2	CID000024394
Disease	Glycosuria	TCF7L2 NEUROD1	5.88e-05	7	50	2	HP_0003076
Disease	neuroimaging measurement	MSX2 ATXN2L TCF7L2 ROR1 PKD1 DCC PMEPA1 PLEKHH3 CRTC2	6.84e-05	1069	50	9	EFO_0004346
Disease	irritable bowel syndrome	TCF7L2 FAM120A DCC PRRC2A	7.29e-05	131	50	4	EFO_0000555
Disease	insulin metabolic clearance rate measurement, glucose homeostasis measurement	SLC43A3 DCC	2.53e-04	14	50	2	EFO_0006830, EFO_0006896
Disease	chenodeoxycholate measurement	TCF7L2 DCC	2.91e-04	15	50	2	EFO_0010471
Disease	grip strength measurement	ATXN2L TCF7L2 PKD1 PAX2 PRRC2A	3.12e-04	350	50	5	EFO_0006941
Disease	health study participation	ATXN2L TCF7L2 FAM120A PRRC2A	3.36e-04	195	50	4	EFO_0010130
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	ATXN2L TCF7L2 SKOR1 PMEPA1 PRRC2A	3.73e-04	364	50	5	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	cortical surface area measurement	MSX2 ATXN2L TCF7L2 ROR1 PKD1 PAX2 PMEPA1 PRRC2A TBX6	3.82e-04	1345	50	9	EFO_0010736
Disease	Female Urogenital Diseases	MSX2 PAX2	4.23e-04	18	50	2	C1720887
Disease	multisite chronic pain	FAM120A DCC PMEPA1	5.68e-04	95	50	3	EFO_0010100
Disease	Anophthalmia-microphthalmia syndrome	PAX2 BCOR	5.79e-04	21	50	2	cv:C5680330
Disease	neurotic disorder	FAM120A DCC PMEPA1	6.79e-04	101	50	3	EFO_0004257
Disease	TYPE 2 DIABETES MELLITUS	TCF7L2 NEUROD1	1.03e-03	28	50	2	125853
Disease	Type 2 diabetes mellitus	TCF7L2 NEUROD1	1.03e-03	28	50	2	cv:C0011860
Disease	age at first birth measurement	TCF7L2 PRRC2A CRTC2	1.12e-03	120	50	3	EFO_0009101
Disease	colorectal cancer (is_implicated_in)	TCF7L2 DCC BCOR	1.15e-03	121	50	3	DOID:9256 (is_implicated_in)
Disease	body fat percentage	ATXN2L TCF7L2 SKOR1 PMEPA1 PRRC2A	1.39e-03	488	50	5	EFO_0007800
Disease	verbal-numerical reasoning measurement	ATXN2L FAM120A DCC	1.44e-03	131	50	3	EFO_0008394

Protein segments in the cluster

Peptide	Gene	Start	Entry
SYPGAGHLIEPPYSP	BAAT	356	Q14032
PYFSPLYTFPIHIGG	CSPG4	881	Q6UVK1
HEYPGELGQPPGLYP	CACNB1	466	Q02641
HLPLPYYSPVGLGAA	EVX1	276	P49640
PSYGALPPAYGPPAH	CCNK	456	O75909
YYAPAPLPPGVSGFL	CEP78	376	Q5JTW2
GERFLYLPPPHYVGP	BCOR	241	Q6W2J9
VAYPDYFGHIPPPFK	AGTPBP1	646	Q9UPW5
STPSPYPYIGHPQGE	ATXN2L	1016	Q8WWM7
VPIAPPFFPHVWYGY	OTUD4	851	Q01804
YPGILPSPTCGYPHP	DCC	1261	P43146
GYLYPRSHPGDPPSG	FUT4	331	P22083
PGFTGYFIPTPPSSY	KIAA1549L	1721	Q6ZVL6
YPASAYPRHFGPVPP	FAM120A	866	Q9NZB2
YGHPQAPHLYPGPSP	FOXJ2	516	Q9P0K8
FYVGGYPSTFTPPPL	LAMA5	2876	O15230
YPPHVPPTGQGSYPT	PAX2	341	Q02962
EGPPPTYSEVIGHYP	PMEPA1	226	Q969W9
SPGFPYVYHIRGFPL	PRR27	81	Q6MZM9
GYADPLRHYPAPYGP	HOXB6	31	P17509
PPQPSPGHFVYTGYP	GBX2	31	P52951
GLVPFGLYLPAPPLY	CPLANE1	1146	Q9H799
GRQSHYGTPYPPGPS	CRTC2	526	Q53ET0
SPPYIFSPIPFLGHA	CYP51A1	66	Q16850
PYPYPGLVCGVPNTH	IGFLR1	196	Q9H665
GSILYGTHGPLPPLY	FRY	1301	Q5TBA9
PPAVAIGFPPYYAHT	GJA3	261	Q9Y6H8
IGFPPYYAHTAAPLG	GJA3	266	Q9Y6H8
PSRPTEFAFYPGYPG	HOXB13	121	Q92826
GPPHGLARPEALYYP	BCL3	71	P20749
IHGFAPYFYTPAPPG	POLD1	141	P28340
PYFYTPAPPGFGPEH	POLD1	146	P28340
TPEPHYVPGYAGFFP	FAM166A	11	Q6J272
FYPHPLPSPGGVLYT	PKD1	1146	P98161
YGASYPFHRPVLPIP	MSX2	236	P35548
PLFPHPYGFPTAFGL	SKOR1	391	P84550
LLPLPYGVSAPGPGY	PLEKHH3	246	Q7Z736
PAGGVLYPPPSFLYS	PRRC2A	1916	P48634
GHIPYPLPPNYSYGL	SLC43A3	211	Q8NBI5
GLGLYPPAYGPIPSL	PROB1	936	E7EW31
YFLPGPHYFPSSTCP	SOX30	616	O94993
PGTGHYIEPPYFPLC	ACOT4	356	Q8N9L9
GYPIPPGYAAFPAAH	ROR1	821	Q01973
ALPPHYGRPYPFLLQ	TNRC18	1086	O15417
AGGYPLVYPGHPLQP	ZNF703	411	Q9H7S9
PYYPLSPGTVGQIPH	TCF7L2	241	Q9NQB0
GGFYLVPTFSLPPAP	PPP1R3F	111	Q6ZSY5
PFPLPYTAPGGYLDV	TBX6	416	O95947
TPPSLAGHPLYPYGF	ZNF503	491	Q96F45
SYDPTKHPGPPFYVP	TPMT	186	P51580
YPLLLPPPHLFTYGA	ZNF683	196	Q8IZ20
YSPPPFGLLGTAPAY	JMJD8	151	Q96S16
VHPYSYQSPGLPSPP	NEUROD1	216	Q13562