Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	TANK USP11 MINDY4B USP24 ATXN3L USP15	2.15e-04	114	149	6	GO:0004843
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH3 DNAH9 DNAH11	3.06e-04	18	149	3	GO:0008569
GeneOntologyMolecularFunction	deubiquitinase activity	TANK USP11 MINDY4B USP24 ATXN3L USP15	3.38e-04	124	149	6	GO:0101005
GeneOntologyMolecularFunction	zinc ion binding	MORC1 RAG1 TRAF6 PEG10 POLE ADAMTS8 MORC2 TRIM59 RBM20 LTN1 CDADC1 RABGEF1 AGBL2 MARCHF1 TET3 ZMYM3 SMAD3	3.60e-04	891	149	17	GO:0008270
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	MINDY4B ATXN3L USP15	4.91e-04	21	149	3	GO:1990380
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	TANK USP11 MINDY4B USP24 ATXN3L USP15	5.75e-04	137	149	6	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	TANK USP11 MINDY4B USP24 CASP4 ATXN3L USP15	6.06e-04	192	149	7	GO:0008234
GeneOntologyCellularComponent	side of membrane	OTOA LYPD4 TRAF6 CEACAM5 PSG2 PRSS41 LRRK2 BTLA TECTA LY6G5C AMOT GLRB LRP2 SCNN1G LY75 IGSF21 KLRD1 RECK IL6ST	1.39e-05	875	148	19	GO:0098552
GeneOntologyCellularComponent	endosome lumen	APOB GH1 GH2 LRP2	2.40e-04	43	148	4	GO:0031904
GeneOntologyCellularComponent	external side of plasma membrane	CEACAM5 PSG2 BTLA LY6G5C AMOT GLRB LRP2 SCNN1G LY75 IGSF21 KLRD1 IL6ST	3.32e-04	519	148	12	GO:0009897
HumanPheno	Abnormal urine chloride concentration	SLC12A1 CLCNKA CLCNKB	9.33e-06	5	51	3	HP:0012600
HumanPheno	Hyperchloriduria	SLC12A1 CLCNKA CLCNKB	9.33e-06	5	51	3	HP:0002914
HumanPheno	Abnormal circulating prostaglandin circulation	SLC12A1 CLCNKA CLCNKB	1.85e-05	6	51	3	HP:0011023
HumanPheno	Hyperprostaglandinuria	SLC12A1 CLCNKA CLCNKB	1.85e-05	6	51	3	HP:0003527
HumanPheno	Metabolic alkalosis	SLC12A1 CLCNKA CLCNKB SCNN1G	2.46e-05	18	51	4	HP:0200114
HumanPheno	Increased circulating renin concentration	SLC12A1 CLCNKA CLCNKB SCNN1G	3.09e-05	19	51	4	HP:0000848
HumanPheno	Hypochloremia	SLC12A1 CLCNKA CLCNKB	3.22e-05	7	51	3	HP:0003113
HumanPheno	Abnormal circulating unsaturated fatty acid concentration	SLC12A1 CLCNKA CLCNKB	5.11e-05	8	51	3	HP:0011022
HumanPheno	Hyperactive renin-angiotensin system	SLC12A1 CLCNKA CLCNKB	5.11e-05	8	51	3	HP:0000841
HumanPheno	Abnormal circulating eicosanoid concentration	SLC12A1 CLCNKA CLCNKB	5.11e-05	8	51	3	HP:0030361
HumanPheno	Hypokalemic metabolic alkalosis	SLC12A1 CLCNKA CLCNKB	7.61e-05	9	51	3	HP:0001960
HumanPheno	Increased urinary potassium	SLC12A1 CLCNKA CLCNKB	7.61e-05	9	51	3	HP:0003081
HumanPheno	Hypokalemic alkalosis	SLC12A1 CLCNKA CLCNKB	1.95e-04	12	51	3	HP:0001949
HumanPheno	Fetal polyuria	SLC12A1 CLCNKA CLCNKB	1.95e-04	12	51	3	HP:0001563
HumanPheno	Alkalosis	SLC12A1 CLCNKA CLCNKB SCNN1G	2.02e-04	30	51	4	HP:0001948
HumanPheno	Increased circulating aldosterone concentration	SLC12A1 CLCNKA CLCNKB SCNN1G	2.61e-04	32	51	4	HP:0000859
HumanPheno	Hypokalemic hypochloremic metabolic alkalosis	CLCNKA CLCNKB	2.93e-04	3	51	2	HP:0004909
HumanPheno	Abnormal circulating renin concentration	SLC12A1 CLCNKA CLCNKB SCNN1G	2.94e-04	33	51	4	HP:0040084
Domain	Cl_channel-K	CLCNKA CLCNKB	5.82e-05	2	143	2	IPR002250
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	IPR013602
Domain	DHC_N2	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	IPR011704
Domain	MT	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	PF12777
Domain	AAA_8	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	PF12780
Domain	AAA_5	DNAH3 DNAH9 DNAH11	1.50e-04	14	143	3	PF07728
Domain	USP7_C2	USP11 USP15	1.74e-04	3	143	2	PF14533
Domain	USP_C	USP11 USP15	1.74e-04	3	143	2	IPR029346
Domain	DHC_fam	DNAH3 DNAH9 DNAH11	1.87e-04	15	143	3	IPR026983
Domain	Dynein_heavy	DNAH3 DNAH9 DNAH11	1.87e-04	15	143	3	PF03028
Domain	Dynein_heavy_dom	DNAH3 DNAH9 DNAH11	1.87e-04	15	143	3	IPR004273
Domain	Ubiquitin_3	USP11 USP15	3.46e-04	4	143	2	PF14836
Domain	Ub_USP-typ	USP11 USP15	3.46e-04	4	143	2	IPR028135
Domain	Somatotropin_CS	GH1 GH2	5.73e-04	5	143	2	IPR018116
Domain	SOMATOTROPIN_2	GH1 GH2	8.56e-04	6	143	2	PS00338
Domain	SOMATOTROPIN_1	GH1 GH2	8.56e-04	6	143	2	PS00266
Domain	DUSP	USP11 USP15	8.56e-04	6	143	2	PF06337
Domain	DUSP	USP11 USP15	8.56e-04	6	143	2	SM00695
Domain	Hormone_1	GH1 GH2	8.56e-04	6	143	2	PF00103
Domain	zf-CW	MORC1 MORC2	1.19e-03	7	143	2	PF07496
Domain	Somatotropin	GH1 GH2	1.19e-03	7	143	2	IPR001400
Domain	ZF_CW	MORC1 MORC2	1.19e-03	7	143	2	PS51050
Domain	DUSP	USP11 USP15	1.19e-03	7	143	2	PS51283
Domain	SLC12A_fam	SLC12A1 SLC12A7	1.19e-03	7	143	2	IPR004842
Domain	Znf_CW	MORC1 MORC2	1.19e-03	7	143	2	IPR011124
Domain	-	USP11 USP15	1.19e-03	7	143	2	3.30.2230.10
Domain	Pept_C19_DUSP	USP11 USP15	1.19e-03	7	143	2	IPR006615
Domain	ARM-type_fold	DCAF1 CIP2A LRRK2 USP24 APOB CUL7 FOCAD PPP4R3B LTN1	1.22e-03	339	143	9	IPR016024
Domain	SLC12_C	SLC12A1 SLC12A7	1.58e-03	8	143	2	IPR018491
Domain	DHC_N1	DNAH9 DNAH11	1.58e-03	8	143	2	PF08385
Domain	SLC12	SLC12A1 SLC12A7	1.58e-03	8	143	2	PF03522
Domain	Dynein_heavy_dom-1	DNAH9 DNAH11	1.58e-03	8	143	2	IPR013594
Domain	Cl-channel_core	CLCNKA CLCNKB	2.02e-03	9	143	2	IPR014743
Domain	-	CLCNKA CLCNKB	2.02e-03	9	143	2	1.10.3080.10
Domain	Voltage_CLC	CLCNKA CLCNKB	2.02e-03	9	143	2	PF00654
Domain	Cl-channel_volt-gated	CLCNKA CLCNKB	2.02e-03	9	143	2	IPR001807
Domain	Znf_C3HC4_RING-type	RAG1 TRAF6 TRIM59 LTN1 RNF10 MARCHF1	2.11e-03	172	143	6	IPR018957
Domain	-	FMR1NB SI	3.06e-03	11	143	2	4.10.110.10
Domain	P_trefoil_dom	FMR1NB SI	3.65e-03	12	143	2	IPR000519
Domain	-	DCAF1 LRRK2 PALB2 SEMA4C WDR87 RMC1 RIC1 NSMAF	4.17e-03	333	143	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DCAF1 LRRK2 PALB2 SEMA4C WDR87 RMC1 RIC1 NSMAF	4.32e-03	335	143	8	IPR015943
Domain	Ig_V-set	CEACAM5 PSG2 SIRPB1 VSIG10 ROBO1 IGSF21	4.34e-03	199	143	6	IPR013106
Domain	ARM-like	DCAF1 SETX CIP2A LRRK2 CUL7 PPP4R3B LTN1	4.82e-03	270	143	7	IPR011989
Domain	FN_type2_col-bd	MRC1 LY75	4.99e-03	14	143	2	IPR000562
Domain	FN2_2	MRC1 LY75	4.99e-03	14	143	2	PS51092
Domain	TIL_dom	TECTA LRP2	4.99e-03	14	143	2	IPR002919
Domain	FN2_1	MRC1 LY75	4.99e-03	14	143	2	PS00023
Domain	fn2	MRC1 LY75	4.99e-03	14	143	2	PF00040
Domain	FN2	MRC1 LY75	4.99e-03	14	143	2	SM00059
Domain	CBS	CLCNKA CLCNKB	6.51e-03	16	143	2	SM00116
Domain	GRAM	SBF1 NSMAF	6.51e-03	16	143	2	SM00568
Domain	VWF_type-D	TECTA VWDE	6.51e-03	16	143	2	IPR001846
Domain	Laminin_N	LAMA1 USH2A	6.51e-03	16	143	2	IPR008211
Domain	VWFD	TECTA VWDE	6.51e-03	16	143	2	PS51233
Domain	LamNT	LAMA1 USH2A	6.51e-03	16	143	2	SM00136
Domain	VWD	TECTA VWDE	6.51e-03	16	143	2	SM00216
Domain	LAMININ_NTER	LAMA1 USH2A	6.51e-03	16	143	2	PS51117
Domain	Laminin_N	LAMA1 USH2A	6.51e-03	16	143	2	PF00055
Domain	VWD	TECTA VWDE	6.51e-03	16	143	2	PF00094
Domain	Znf_RING-CH	LTN1 MARCHF1	7.34e-03	17	143	2	IPR011016
Domain	RINGv	LTN1 MARCHF1	7.34e-03	17	143	2	SM00744
Domain	zf-C3HC4	RAG1 TRAF6 TRIM59 LTN1 RNF10 MARCHF1	7.47e-03	223	143	6	PF00097
Pathway	REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS	OTOA LYPD4 CEACAM5 PSG2 PRSS41 TECTA RECK	1.20e-05	99	110	7	MM14624
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SECISBP2L RALGDS SETX OGT TTC28 SCAF8 POLE MYO19 LARP1 C15orf39 MORC2 RBM20 SBF1 ZC3H7B SLC12A7 PCDHGC3 RIC1 ZC3HAV1	5.53e-10	650	151	18	38777146
Pubmed	Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.	SLC12A1 CLCNKA CLCNKB SCNN1G	1.18e-08	7	151	4	34499620
Pubmed	Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption.	NEDD4L CLCNKA CLCNKB	3.20e-07	4	151	3	17652939
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETX OGT TTC28 RB1 USP11 CIP2A C15orf39 CEP192 CUL7 RBM20 PPP4R3B CYFIP1 ZMYM3	1.93e-06	588	151	13	38580884
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	OGT TTC28 CIP2A USP24 C15orf39 RBM20 PALB2 AMOT ZBTB10 LRP2 ZMYM3	2.36e-06	418	151	11	34709266
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	SECISBP2L OGT TTC28 USP11 POLE CIP2A MYO19 PPP4R3B AGL RIMOC1 SFXN2 RARS2 ZC3HAV1	2.68e-06	606	151	13	36538041
Pubmed	Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.	SLC12A1 CLCNKA CLCNKB	2.77e-06	7	151	3	11423561
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TTC28 SCAF8 PEG10 USP24 AMOT ZC3H7B	6.48e-06	104	151	6	10470851
Pubmed	BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.	CYBB RAG1 STING1	6.61e-06	9	151	3	32376769
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DCAF1 OGT TTC28 RB1 USP11 SIRPB1 CUL7 GPR108 SLC25A43 CLCNKA LTN1 ZBTB10 LRP2 SFXN2 TEKT1 RARS2 ZMYM3	7.72e-06	1116	151	17	31753913
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	CYBB MRC1 DLGAP1 SLC25A21 CEACAM5 PSG2 FMR1NB LRRK2 ADAMTS8 STING1 MORC2 EGFL6 LY75	8.42e-06	674	151	13	37196079
Pubmed	Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.	CYBB SIRPB1 STING1	9.41e-06	10	151	3	28801234
Pubmed	NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.	DCAF1 NEDD4L AMOT	9.41e-06	10	151	3	33058421
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AKAP6 USP11 PEG10 AKAP9 AMOT AGL SYNE2 RNF10 RABGEF1 IL6ST SMAD3	1.21e-05	497	151	11	23414517
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DCAF1 NEDD4L TTC28 SCAF8 CEP192 FOCAD AKAP9 USP15 TET3 ZMYM3	1.25e-05	407	151	10	12693553
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 DLGAP1 TRAF6 OGT TTC28 USP11 PEG10 PLA2G3 ZNF189 ADAMTS8 TRIM59 FOCAD PPP4R3B PPP3CB RNF10 LRP2 ROBO1 RECK	1.28e-05	1285	151	18	35914814
Pubmed	Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the retinoblastoma gene.	RB1 GH1 GH2	1.29e-05	11	151	3	1679528
Pubmed	Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension.	SLC12A1 CLCNKA SCNN1G	1.72e-05	12	151	3	23684652
Pubmed	The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.	CLCNKA CLCNKB	1.87e-05	2	151	2	27335120
Pubmed	Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.	CLCNKA CLCNKB	1.87e-05	2	151	2	8812470
Pubmed	T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma.	RAG1 USP15	1.87e-05	2	151	2	26686633
Pubmed	Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.	CLCNKA CLCNKB	1.87e-05	2	151	2	25919862
Pubmed	Isolation and characterization of the mouse ubiquitin-specific protease Usp15.	USP11 USP15	1.87e-05	2	151	2	12532266
Pubmed	5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.	CYBB STING1	1.87e-05	2	151	2	23027866
Pubmed	Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.	CLCNKA CLCNKB	1.87e-05	2	151	2	38069401
Pubmed	TET3-OGT interaction increases the stability and the presence of OGT in chromatin.	OGT TET3	1.87e-05	2	151	2	24304661
Pubmed	Biodegradable nanoparticles induce cGAS/STING-dependent reprogramming of myeloid cells to promote tumor immunotherapy.	RAG1 STING1	1.87e-05	2	151	2	36059473
Pubmed	STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma.	RAG1 STING1	1.87e-05	2	151	2	36959214
Pubmed	A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.	CLCNKA CLCNKB	1.87e-05	2	151	2	20805576
Pubmed	Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes.	RAG1 RB1	1.87e-05	2	151	2	23469070
Pubmed	Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.	NEDD4L AMOT	1.87e-05	2	151	2	34284061
Pubmed	Truncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor.	APOB LRP2	1.87e-05	2	151	2	10330424
Pubmed	TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis.	RAG1 TRAF6	1.87e-05	2	151	2	16921377
Pubmed	Salt wasting and deafness resulting from mutations in two chloride channels.	CLCNKA CLCNKB	1.87e-05	2	151	2	15044642
Pubmed	Two highly homologous members of the ClC chloride channel family in both rat and human kidney.	CLCNKA CLCNKB	1.87e-05	2	151	2	8041726
Pubmed	A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.	CLCNKA CLCNKB	1.87e-05	2	151	2	18648499
Pubmed	Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.	CLCNKA CLCNKB	1.87e-05	2	151	2	8544406
Pubmed	The human growth hormone gene family: structure and evolution of the chromosomal locus.	GH1 GH2	1.87e-05	2	151	2	6306568
Pubmed	Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.	CLCNKA CLCNKB	1.87e-05	2	151	2	24863058
Pubmed	Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.	CLCNKA CLCNKB	1.87e-05	2	151	2	9916798
Pubmed	Kidney kinetics and chloride ion pumps.	CLCNKA CLCNKB	1.87e-05	2	151	2	9916791
Pubmed	TET3- and OGT-Dependent Expression of Genes Involved in Epithelial-Mesenchymal Transition in Endometrial Cancer.	OGT TET3	1.87e-05	2	151	2	34948036
Pubmed	Synergistical effect of 20-HETE and high salt on NKCC2 protein and blood pressure via ubiquitin-proteasome pathway.	NEDD4L SLC12A1	1.87e-05	2	151	2	23104236
Pubmed	Pitx2 participates in the late phase of the pathway controlling left-right asymmetry.	PITX2 DNAH11	1.87e-05	2	151	2	9708734
Pubmed	The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.	PITX2 DNAH11	1.87e-05	2	151	2	10021341
Pubmed	Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels.	CLCNKA CLCNKB	1.87e-05	2	151	2	11014860
Pubmed	Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.	SLC12A1 CLCNKB LRP2 SCNN1G	2.02e-05	37	151	4	16319116
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SETX OGT RB1 USP11 POLE LARP1 CUL7 PRC1 MORC2 AGL PITX2 ZBTB10 ZMYM3 SMAD3	2.40e-05	857	151	14	25609649
Pubmed	Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.	CYBB CASP4 STING1	3.51e-05	15	151	3	25774716
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	TRAF6 TANK NEDD4L RB1 PEG10 STING1 PPP3CB LTN1	3.54e-05	283	151	8	21903422
Pubmed	MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary.	GH1 GH2 PITX2	4.31e-05	16	151	3	30982661
Pubmed	Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.	GH1 GH2 PITX2	5.22e-05	17	151	3	12464179
Pubmed	Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.	SLC12A1 CLCNKB LRP2 SCNN1G	5.27e-05	47	151	4	28527294
Pubmed	Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional.	CLCNKA CLCNKB	5.60e-05	3	151	2	26013830
Pubmed	Autocrine human growth hormone inhibits placental transforming growth factor-beta gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells.	GH1 GH2	5.60e-05	3	151	2	11994274
Pubmed	Barttin increases surface expression and changes current properties of ClC-K channels.	CLCNKA CLCNKB	5.60e-05	3	151	2	12111250
Pubmed	DCAF1 regulates Treg senescence via the ROS axis during immunological aging.	DCAF1 RAG1	5.60e-05	3	151	2	32730228
Pubmed	Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.	CLCNKA CLCNKB	5.60e-05	3	151	2	17510212
Pubmed	Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING.	RAG1 STING1	5.60e-05	3	151	2	36952341
Pubmed	Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.	USP11 USP15	5.60e-05	3	151	2	26503449
Pubmed	The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation.	STING1 MARCHF1	5.60e-05	3	151	2	32606244
Pubmed	USP11 controls R-loops by regulating senataxin proteostasis.	SETX USP11	5.60e-05	3	151	2	34526504
Pubmed	Homozygous deletion of RAG1, RAG2 and 5' region TRAF6 causes severe immune suppression and atypical osteopetrosis.	RAG1 TRAF6	5.60e-05	3	151	2	27808398
Pubmed	A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.	RAG1 STING1	5.60e-05	3	151	2	35263568
Pubmed	Allelic-based gene-gene interaction associated with quantitative traits.	SLC12A1 CLCNKB	5.60e-05	3	151	2	19058262
Pubmed	Barttin modulates trafficking and function of ClC-K channels.	CLCNKA CLCNKB	5.60e-05	3	151	2	16849430
Pubmed	Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.	CLCNKA CLCNKB	5.60e-05	3	151	2	18094726
Pubmed	Structural variability of the ubiquitin specific protease DUSP-UBL double domains.	USP11 USP15	5.60e-05	3	151	2	22001210
Pubmed	Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.	CLCNKA CLCNKB	5.60e-05	3	151	2	10982849
Pubmed	Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ).	TRAF6 CASP4	5.60e-05	3	151	2	18056395
Pubmed	Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice.	PITX2 DNAH11	5.60e-05	3	151	2	11180966
Pubmed	Paired-like homeodomain transcription factors 1 and 2 regulate follicle-stimulating hormone beta-subunit transcription through a conserved cis-element.	PITX2 SMAD3	5.60e-05	3	151	2	18339718
Pubmed	E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation.	NEDD4L IL6ST	5.60e-05	3	151	2	33769697
Pubmed	Growth hormone prevents human immunodeficiency virus-induced neuronal p53 expression.	GH1 GH2	5.60e-05	3	151	2	14595650
Pubmed	Overexpression of TP53INP2 Promotes Apoptosis in Clear Cell Renal Cell Cancer via Caspase-8/TRAF6 Signaling Pathway.	TRAF6 TP53INP2	5.60e-05	3	151	2	35615533
Pubmed	Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.	OTOA TECTA	5.60e-05	3	151	2	11972037
Pubmed	Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis.	RAG1 ZNF189	5.60e-05	3	151	2	36942486
Pubmed	Chromosomal localization of the human placental lactogen-growth hormone gene cluster to 17q22-24.	GH1 GH2	5.60e-05	3	151	2	7072716
Pubmed	USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction.	TRAF6 USP15	5.60e-05	3	151	2	35422093
Pubmed	Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.	CLCNKA CLCNKB	5.60e-05	3	151	2	11734858
Pubmed	Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.	IL6ST SMAD3	5.60e-05	3	151	2	16041381
Pubmed	CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling.	CEACAM5 SMAD3	5.60e-05	3	151	2	17653079
Pubmed	TET2 promotes histone O-GlcNAcylation during gene transcription.	OGT TET3	5.60e-05	3	151	2	23222540
Pubmed	Regulation of RANKL-induced osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6.	TRAF6 SMAD3	5.60e-05	3	151	2	21305609
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	DCAF1 NEDD4L USP11 LAMA1 LARP1 CUL7 AMOT LTN1	7.18e-05	313	151	8	38270169
Pubmed	FOXL2 in the pituitary: molecular, genetic, and developmental analysis.	GH1 GH2 PITX2	7.39e-05	19	151	3	16840539
Pubmed	PITX genes are required for cell survival and Lhx3 activation.	GH1 GH2 PITX2	7.39e-05	19	151	3	15761027
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	DNAH3 ZFP90 C15orf39 TP53INP2 TMEM156 TET3 DNAH11	7.54e-05	233	151	7	37704626
Pubmed	MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression.	GH1 GH2 PITX2	1.01e-04	21	151	3	20807761
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	AKAP6 RAG1 DLGAP1 SH3KBP1 AGPAT4 CUL7 LRP2 SMAD3	1.01e-04	329	151	8	17474147
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SETX NEDD4L TTC28 LARP1 CEP192 TWF1 AKAP9 SBF1 AMOT SYNE2 RNF10 RABGEF1 ZC3HAV1	1.04e-04	861	151	13	36931259
Pubmed	A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.	NEDD4L SCNN1G	1.12e-04	4	151	2	11802777
Pubmed	ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.	APOB ADAMTS8	1.12e-04	4	151	2	17606262
Pubmed	Interleukin-6 signaling drives fibrosis in unresolved inflammation.	RAG1 SMAD3	1.12e-04	4	151	2	24412616
Pubmed	ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells.	ELAC2 SMAD3	1.12e-04	4	151	2	16636667
Pubmed	The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels.	NEDD4L SCNN1G	1.12e-04	4	151	2	12424229
Pubmed	Two populations of node monocilia initiate left-right asymmetry in the mouse.	PITX2 DNAH11	1.12e-04	4	151	2	12859898
Pubmed	Intrinsic STING Switches off Pathogenetic Programs of Th1 Cells to Inhibit Colitis.	RAG1 STING1	1.12e-04	4	151	2	36736893
Pubmed	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.	OGT TET3	1.12e-04	4	151	2	23353889
Pubmed	14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.	NEDD4L SCNN1G	1.12e-04	4	151	2	16716084
Interaction	STK4 interactions	TRAF6 OGT ZNF189 STING1 CUL7 CYFIP1 AKAP9 AMOT RABGEF1	2.72e-06	159	148	9	int:STK4
Interaction	UBE2J2 interactions	NEDD4L KPRP STING1 TRIM59 RNF10	1.21e-05	41	148	5	int:UBE2J2
Interaction	TOMM70 interactions	TRAF6 OGT TTC28 LRRK2 STING1 SYNE2 SFXN2 PLD2	1.76e-05	153	148	8	int:TOMM70
Cytoband	2q24-q31	TANK LRP2	3.22e-05	3	151	2	2q24-q31
Cytoband	19q13.1-q13.2	CEACAM5 PSG2	3.81e-04	9	151	2	19q13.1-q13.2
GeneFamily	Dyneins, axonemal	DNAH3 DNAH9 DNAH11	1.25e-04	17	106	3	536
GeneFamily	Growth hormone family	GH1 GH2	5.03e-04	6	106	2	1175
GeneFamily	Zinc fingers CW-type	MORC1 MORC2	7.01e-04	7	106	2	96
GeneFamily	Chloride voltage-gated channels	CLCNKA CLCNKB	1.49e-03	10	106	2	302
GeneFamily	Phospholipases	PLB1 PLA2G3 PLD2	1.90e-03	42	106	3	467
GeneFamily	Adenosine receptors\|V-set domain containing	CEACAM5 PSG2 SIRPB1 VSIG10 IGSF21	2.73e-03	163	106	5	590
Coexpression	GSE14699_NAIVE_VS_ACT_CD8_TCELL_DN	NEDD4L TTC28 RPP40 USP24 BTLA FOCAD SLC12A7 IL6ST	7.90e-06	175	150	8	M2940
Coexpression	ZHENG_BOUND_BY_FOXP3	RB1 SH3KBP1 BTLA TRIM59 ZBTB25 AMOT SYNE2 TET3 IL6ST NSMAF SMAD3 ZC3HAV1	3.13e-05	498	150	12	M1741
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	SECISBP2L SETX OGT TANK TTC28 RB1 SCAF8 USP24 PPP3CB AKAP9 GLRB SYNE2 LTN1 USP15 NSMAF SMAD3	3.38e-05	856	150	16	M4500
Coexpression	GSE11386_NAIVE_VS_MEMORY_BCELL_DN	OGT PLA2G3 AKAP9 AGL RIMOC1 SLC12A7 IL6ST	3.62e-05	158	150	7	M372
Coexpression	ZHENG_BOUND_BY_FOXP3	RB1 SH3KBP1 BTLA TRIM59 ZBTB25 AMOT SYNE2 TET3 IL6ST NSMAF SMAD3 ZC3HAV1	3.72e-05	507	150	12	MM1030
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-1	CYBB TANK ZNF366 LRRK2 CASP4 SIRPB1 VSIG10 ZBTB10 PLD2 LY75 KLRD1 ALOX5AP RIC1	6.40e-06	414	147	13	GSM538262_500
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b+.Sp, CD11b CD4 CD45 CD11c CD8a, Spleen, avg-1	CYBB ZNF366 LRRK2 SIRPB1 KLRD1 ALOX5AP	1.82e-05	79	147	6	GSM538265_100
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA LAMA1 APOB LRP2 ROBO1 USH2A DNAH9 DNAH11	2.27e-07	184	151	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA LAMA1 APOB LRP2 ROBO1 USH2A DNAH9 DNAH11	2.27e-07	184	151	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA LAMA1 APOB LRP2 ROBO1 USH2A DNAH9 DNAH11	2.27e-07	184	151	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	critical-Myeloid-Neutrophil\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RALGDS TANK LRRK2 CASP4 CREBRF USP15 ALOX5AP NSMAF	3.81e-07	197	151	8	f1248781e71e3a158d06e9ec93eb90dc6d48bcb2
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 LAMA1 TECTA SLC12A1 LRP2 USH2A DNAH9	1.27e-06	160	151	7	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 LAMA1 TECTA SLC12A1 LRP2 USH2A DNAH9	1.27e-06	160	151	7	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Bronchial_Biopsy-Immune-Luminal_Macrophages\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	CYBB OTOA MRC1 SIRPB1 IGSF21 MARCHF1 ALOX5AP	2.30e-06	175	151	7	1cf99de391552d4f8dbe2ed5b01fc3b8adca61b6
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBM20 EGFL6 SLC12A1 CLCNKA CLCNKB SYNE2 AGBL2	3.44e-06	186	151	7	8eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 NEBL LAMA1 LRRK2 SYNE2 KLRD1 DNAH11	3.44e-06	186	151	7	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB MRC1 LRRK2 SIRPB1 IGSF21 MARCHF1 LRRC36	3.83e-06	189	151	7	b8cbfc47f3f40b6fccd15899d58c87d07b0001aa
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	DNAH3 NEDD4L NEBL SYNE2 TEKT1 DNAH9 DNAH11	4.70e-06	195	151	7	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L NEDD4L PEG10 LRRK2 C16orf89 LRP2 LRRC36	4.70e-06	195	151	7	6617abca0009ad3d8731f515f91ab275f9ea4c40
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L NEDD4L PEG10 LRRK2 C16orf89 LRP2 LRRC36	4.70e-06	195	151	7	fc0ae145a2118df7cbbc9ac4ca9dc12d26c087c4
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	DNAH3 NEDD4L NEBL SYNE2 TEKT1 DNAH9 DNAH11	4.70e-06	195	151	7	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|356C / Donor, Lineage, Cell class and subclass (all cells)	CYBB OTOA MRC1 RB1 CYFIP1 IGSF21 MARCHF1	4.70e-06	195	151	7	9231e929657542b78a6480d44402866511129c7f
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Club\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CEACAM5 NEDD4L PLA2G3 C16orf89 MAB21L3 LRP2 SCNN1G	4.86e-06	196	151	7	4e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH3 NEDD4L NEBL SYNE2 TEKT1 DNAH9 DNAH11	4.86e-06	196	151	7	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH3 NEDD4L NEBL SYNE2 TEKT1 DNAH9 DNAH11	4.86e-06	196	151	7	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 DNAH3 AKAP9 KIAA0825 SYNE2 DNAH9 DNAH11	5.02e-06	197	151	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NEDD4L NEBL PEG10 LRRK2 C16orf89 LRP2 LRRC36	5.37e-06	199	151	7	a38a981cffa61c8444a980916de7414e689a1b63
ToppCell	Control_saline-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|Control_saline / Treatment groups by lineage, cell group, cell type	CYBB CEACAM5 SH3KBP1 LRRK2 SIRPB1 GLRB ALOX5AP	5.37e-06	199	151	7	e1240bfcdce76ec018599c50350748f9c7b8fb0e
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MORC1 CYBB TMEM156 RNASE3 IGSF21 MARCHF1 ALOX5AP	5.55e-06	200	151	7	27f498bcd706d0751091662996795b5270e46f14
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RPP40 POLE MYO19 ZBTB25 AMOT LRP2	9.85e-06	144	151	6	1b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MORC1 DNAH3 ZNF366 C16orf89 LY75	9.93e-06	84	151	5	f7ce09c6fb2795b7aecabce00cb9830b3c1a7d0e
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MORC1 DNAH3 ZNF366 C16orf89 LY75	9.93e-06	84	151	5	5d5e519a6652029b9f5275c8e648bbb123fd07b9
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MORC1 DNAH3 ZNF366 C16orf89 LY75	9.93e-06	84	151	5	2b477de422a9f6a8474cba05094577b88236a4f0
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	DNAH3 NEDD4L PRSS41 TEKT1 DNAH9 DNAH11	1.29e-05	151	151	6	8216462e723fec2797387929dde095370947e10a
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	OGT RBM20 SYNE2 TEKT1 DNAH9 DNAH11	1.55e-05	156	151	6	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POLE CIP2A KPRP TECTA USH2A DNAH9	1.92e-05	162	151	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF6 USP11 MORC2 SBF1 KLRD1 NSMAF	2.28e-05	167	151	6	e0f2509e86302eca8352821bce12597f6c51fc24
ToppCell	facs-Lung-EPCAM-24m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF6 USP11 MORC2 SBF1 KLRD1 NSMAF	2.28e-05	167	151	6	b25646b6653cd8814dbeae4c74ce899ede105200
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EME1 SH3KBP1 PRC1 TRIM59 PALB2 NSMAF	2.28e-05	167	151	6	d21635df8b74189e3309eaf435af381fbe412574
ToppCell	Control\|World / group, cell type (main and fine annotations)	DLGAP1 CEACAM5 NEDD4L NEBL LRP2 LRRC36	2.36e-05	168	151	6	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP4 BTLA STING1 PALB2 SLC12A7 KLRD1	2.36e-05	168	151	6	dc1143bd8db70c490167d73a525fd9b783eba960
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP4 BTLA STING1 PALB2 SLC12A7 KLRD1	2.36e-05	168	151	6	a75d63ae8ad64b5560853775f6df398feb314ce8
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	OGT APOB AKAP9 SYNE2 IL6ST ZC3HAV1	2.61e-05	171	151	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CIP2A TRIM59 CLCNKA CLCNKB SCNN1G ROBO1	2.69e-05	172	151	6	04fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CIP2A TRIM59 CLCNKA CLCNKB SCNN1G ROBO1	2.69e-05	172	151	6	dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AKAP6 PEG10 BTLA TMEM156 ZBTB10 MARCHF1	2.69e-05	172	151	6	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CYBB MRC1 PITX2 IGSF21 MARCHF1 RIC1	2.78e-05	173	151	6	8384d533a1071fc65a06e6d9f5f17d8ab00c3966
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	C16orf89 TSPAN17 ROBO1 RARS2 DNAH9 KLRD1	2.78e-05	173	151	6	5295ed31648abf8edff214cf67cd4769f20f9e6d
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EME1 PLB1 CIP2A PRC1 TRIM59 PLD2	2.87e-05	174	151	6	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EME1 PLB1 CIP2A PRC1 TRIM59 PLD2	2.87e-05	174	151	6	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	Severe-CD4+_T_activated\|Severe / Disease group and Cell class	PEG10 STING1 VWDE C16orf89 DNAH9 ALOX5AP	3.16e-05	177	151	6	a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 BTLA KIAA0825 AMOT ZC3H7B KLRD1	3.16e-05	177	151	6	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 DNAH3 TEKT1 AGBL2 DNAH9 DNAH11	3.26e-05	178	151	6	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB BTLA SIRPB1 TMEM156 ALOX5AP LRRC36	3.26e-05	178	151	6	b7d1d8f76c1c2467b1a39a9b4150ed4a47144a15
ToppCell	droplet-Kidney-nan-18m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOB SLC12A1 CLCNKA CLCNKB LRP2 AGBL2	3.48e-05	180	151	6	cd743f81838ba210e5bb63fe0870918d7d2b0112
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	SECISBP2L DLGAP1 NEDD4L LRRK2 LRP2 LRRC36	3.48e-05	180	151	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH3 RBM20 SLC12A1 LRP2 SFXN2 USH2A	3.58e-05	181	151	6	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 RB1 CYFIP1 IGSF21 MARCHF1 ZC3HAV1	3.70e-05	182	151	6	4a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 RB1 CYFIP1 IGSF21 MARCHF1 ZC3HAV1	3.70e-05	182	151	6	53213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 RB1 CYFIP1 IGSF21 MARCHF1 ZC3HAV1	3.70e-05	182	151	6	7909089ed6325c44edd6f9b7e8b1d542398222ea
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	NEDD4L NEBL LRRK2 C16orf89 LRP2 LRRC36	3.81e-05	183	151	6	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	3'_v3-Lung-Myeloid_Dendritic-DC1\|Lung / Manually curated celltypes from each tissue	AKAP6 CEACAM5 ZNF366 BTLA ROBO1 IGSF21	3.81e-05	183	151	6	e4cbd39575b5a4612d9934532e3bad63286f8aa5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYBB OTOA MRC1 SIRPB1 TECTA CYFIP1	4.05e-05	185	151	6	7bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCell	343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|343B / Donor, Lineage, Cell class and subclass (all cells)	CYBB MRC1 RB1 IGSF21 MARCHF1 ALOX5AP	4.05e-05	185	151	6	d4ba36bdb8b7e3a62e827269484f89f790eaa5ef
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 NEBL LAMA1 LRRK2 SYNE2 KLRD1	4.30e-05	187	151	6	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LYPD4 C15orf39 APOB SIRPB1 CYFIP1 PLD2	4.30e-05	187	151	6	5917bdfe84cf5941e21b415aebbab3090cc5d576
ToppCell	normal-na-Lymphocytic_B-B_naive-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	AKAP6 RB1 PEG10 BTLA TMEM156 MARCHF1	4.43e-05	188	151	6	ec72ba73b10c6f2ff39699b6b46b90a3e95a4c24
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SECISBP2L PEG10 BTLA TMEM156 ZBTB10 MARCHF1	4.43e-05	188	151	6	d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|368C / Donor, Lineage, Cell class and subclass (all cells)	CYBB MRC1 RB1 IGSF21 MARCHF1 ALOX5AP	4.70e-05	190	151	6	cbba3d94a4c3e0b0d14f3b7c60dba5d6e097c5e3
ToppCell	390C-Myeloid-Macrophage\|390C / Donor, Lineage, Cell class and subclass (all cells)	CYBB OTOA MRC1 SIRPB1 IGSF21 MARCHF1	4.70e-05	190	151	6	f933d971f092c4e56e9f670a9205b688c8b1ca28
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 AGPAT4 RBM20 SLC12A1 CLCNKA CLCNKB	4.70e-05	190	151	6	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	Bronchial_Brush-Immune-Luminal_Macrophages\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CYBB OTOA MRC1 SIRPB1 MARCHF1 ALOX5AP	4.84e-05	191	151	6	88cb6f828407845918c946f8cee5f940cb81800a
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYBB MRC1 TMEM156 IGSF21 MARCHF1 ALOX5AP	4.98e-05	192	151	6	ae7513fde6e33a1908c2777cdb1d1e4ead1bcb2f
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	DLGAP1 TTC28 PEG10 AKAP9 TBCK ROBO1	4.98e-05	192	151	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 AGPAT4 RBM20 SLC12A1 CLCNKA CLCNKB	4.98e-05	192	151	6	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	NS-critical-d_0-4-Myeloid-Neutrophil\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TANK LRRK2 CASP4 CREBRF ALOX5AP NSMAF	4.98e-05	192	151	6	3db74359c30172a51177e00eac1f48f483e15578
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL LAMA1 SLC12A1 AKAP9 CLCNKA SYNE2	4.98e-05	192	151	6	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SECISBP2L NEDD4L LRRK2 C16orf89 LRP2 LRRC36	5.12e-05	193	151	6	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	AKAP6 DNAH3 KIAA0825 TEKT1 DNAH9 DNAH11	5.12e-05	193	151	6	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	SECISBP2L NEDD4L NEBL LRRK2 C16orf89 LRRC36	5.12e-05	193	151	6	8187f976fd2d11fad3286690f1a046e894772220
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	DLGAP1 TTC28 PEG10 AKAP9 TBCK ROBO1	5.12e-05	193	151	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SECISBP2L NEDD4L LRRK2 C16orf89 LRP2 LRRC36	5.12e-05	193	151	6	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L NEDD4L PEG10 C16orf89 SCNN1G IL6ST	5.27e-05	194	151	6	5b29c843186c2394f5bec3b1d5ae284a0d931d85
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|367C / Donor, Lineage, Cell class and subclass (all cells)	AKAP6 CYBB MRC1 RB1 IGSF21 MARCHF1	5.27e-05	194	151	6	e3688f4252aae5f849f025d7f453ff4c0c14590b
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB MRC1 RB1 CYFIP1 IGSF21 MARCHF1	5.27e-05	194	151	6	48c37251518f96524807b5bd1bbc2820637666ad
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L NEDD4L PEG10 C16orf89 SCNN1G IL6ST	5.27e-05	194	151	6	ebcf6c6d0eb20a5d422becf5a730089230c8ba9a
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB MRC1 RB1 CYFIP1 IGSF21 MARCHF1	5.27e-05	194	151	6	7b6a34d1f8922b71dcc931421666c1822cec8345
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L NEDD4L PEG10 C16orf89 SCNN1G IL6ST	5.27e-05	194	151	6	8c6e5ba27a988e0cd6b8c25cb9a30a0da2b1f7f9
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L NEDD4L PEG10 C16orf89 SCNN1G IL6ST	5.27e-05	194	151	6	6e78e3046c5b172af92a84e25f982377a0aaac58
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB MRC1 RB1 CYFIP1 IGSF21 MARCHF1	5.27e-05	194	151	6	435406ebe626c702f7d5a99a3d68ee85aa09be95
ToppCell	(2)_Mono_macro\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	CYBB OTOA MRC1 SIRPB1 MARCHF1 ALOX5AP	5.27e-05	194	151	6	7c05525614ee8cdfcbf22cce9146a8e73af7d14e
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	DNAH3 NEBL SYNE2 TEKT1 DNAH9 DNAH11	5.43e-05	195	151	6	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	LV-03._Atrial_Cardiomyocyte\|LV / Chamber and Cluster_Paper	AKAP6 NEBL PLA2G3 APOB RBM20	5.57e-05	120	151	5	3b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L PEG10 LRRK2 C16orf89 LRP2 LRRC36	5.58e-05	196	151	6	82b117be41f2e7d677a42d2a5198726eeccb16d0
ToppCell	cellseq-Epithelial-Epithelial_Alveolar\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SECISBP2L NEDD4L NEBL PEG10 LRRK2 C16orf89	5.58e-05	196	151	6	a7cbe66ebd8931ef2b8ff26a42afce0ad1c48f17
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	DNAH3 NEDD4L NEBL TEKT1 DNAH9 DNAH11	5.58e-05	196	151	6	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L MRC1 PEG10 LRRK2 C16orf89 LRP2	5.58e-05	196	151	6	006d783a530aa6e1e6545dcc2e6b00bb300fe070
ToppCell	(3)_Macrophage_MARCOneg\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CYBB MRC1 RB1 CYFIP1 IGSF21 MARCHF1	5.74e-05	197	151	6	b0ee2ce1179b60b4542559acb300a34295277dbc
ToppCell	wk_15-18-Hematologic-Myeloid-CX3CR1+_Mac\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CYBB MRC1 PLB1 RB1 IGSF21 MARCHF1	5.74e-05	197	151	6	701334bc164e3b41132232f27574a87e9c3a5be5
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SECISBP2L NEDD4L LRRK2 C16orf89 ZBTB10 LRRC36	5.74e-05	197	151	6	bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCell	NS-critical-d_07-13-Myeloid-Neutrophil\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TANK LRRK2 SIRPB1 CREBRF ALOX5AP NSMAF	5.74e-05	197	151	6	f38037dfa6c33e9336130d0cc65eaba0f120efb9
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SECISBP2L NEDD4L NEBL LRRK2 LRP2 LRRC36	5.91e-05	198	151	6	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	distal-Epithelial-Club-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CEACAM5 NEDD4L PEG10 C16orf89 SCNN1G SMAD3	5.91e-05	198	151	6	77c7fa7626ea35cb50de9c2f2df637d22e77d3fe
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SECISBP2L NEDD4L NEBL LRRK2 LRP2 LRRC36	5.91e-05	198	151	6	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	critical-Myeloid-Neutrophil\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TANK LRRK2 SIRPB1 CREBRF ALOX5AP NSMAF	5.91e-05	198	151	6	4da73dc3acb29d70b160903600d2bf7fdab34333
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 CEACAM5 NEBL AKAP9 DNAH9 DNAH11	5.91e-05	198	151	6	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	367C-Myeloid-Dendritic-cDC2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CYBB MRC1 RB1 CASP4 GPR108 ALOX5AP	6.07e-05	199	151	6	4faf4ed555dac1e1d40f9a1e586a22656974436f
Disease	Bartter syndrome	SLC12A1 CLCNKA CLCNKB	2.40e-06	6	147	3	cv:C0004775
Disease	Bartter disease type 4B	CLCNKA CLCNKB	2.47e-05	2	147	2	cv:C4310805
Disease	Bartter disease type 3 (implicated_via_orthology)	CLCNKA CLCNKB	2.47e-05	2	147	2	DOID:0110144 (implicated_via_orthology)
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	2.47e-05	2	147	2	613090
Disease	BARTTER SYNDROME, TYPE 4B	CLCNKA CLCNKB	2.47e-05	2	147	2	C2751312
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	2.47e-05	2	147	2	C4310805
Disease	Bartter disease type 4b (is_implicated_in)	CLCNKA CLCNKB	2.47e-05	2	147	2	DOID:0110146 (is_implicated_in)
Disease	Bartter disease (implicated_via_orthology)	CLCNKA CLCNKB	2.47e-05	2	147	2	DOID:445 (implicated_via_orthology)
Disease	Colorectal Carcinoma	AKAP6 RALGDS DNAH3 POLE LAMA1 APOB AKAP9 LRP2 SCNN1G IGSF21 IL6ST SMAD3	2.16e-04	702	147	12	C0009402
Disease	aortic valve stenosis (is_implicated_in)	APOB PPP3CB	2.44e-04	5	147	2	DOID:1712 (is_implicated_in)
Disease	Bartter Disease	SLC12A1 CLCNKB	2.44e-04	5	147	2	C0004775
Disease	isolated growth hormone deficiency type II (implicated_via_orthology)	GH1 GH2	2.44e-04	5	147	2	DOID:0060872 (implicated_via_orthology)
Disease	cardiac arrhythmia	AKAP6 NEBL PITX2	4.46e-04	30	147	3	EFO_0004269
Disease	autosomal dominant polycystic kidney disease (biomarker_via_orthology)	PITX2 LRP2	5.09e-04	7	147	2	DOID:898 (biomarker_via_orthology)
Disease	isolated growth hormone deficiency (implicated_via_orthology)	GH1 GH2	5.09e-04	7	147	2	DOID:0060870 (implicated_via_orthology)
Disease	X-17676 measurement	DNAH3 TAS1R2	6.77e-04	8	147	2	EFO_0800785
Disease	lung cancer (implicated_via_orthology)	POLE ROBO1	8.67e-04	9	147	2	DOID:1324 (implicated_via_orthology)
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	CLCNKA CLCNKB	1.08e-03	10	147	2	DOID:12387 (implicated_via_orthology)
Disease	urate measurement, bone density	AKAP6 PLB1 TTC28 PSG2 TMEM156 ROBO1 USH2A MARCHF1 DNAH9 DNAH11	1.12e-03	619	147	10	EFO_0003923, EFO_0004531
Disease	Paroxysmal atrial fibrillation	AKAP6 NEBL RBM20 SYNE2 PITX2	1.13e-03	156	147	5	C0235480
Disease	familial atrial fibrillation	AKAP6 NEBL RBM20 SYNE2 PITX2	1.13e-03	156	147	5	C3468561
Disease	Persistent atrial fibrillation	AKAP6 NEBL RBM20 SYNE2 PITX2	1.13e-03	156	147	5	C2585653
Disease	chronic kidney disease	RB1 MYO19 AGL LRP2 MARCHF1 TET3	1.19e-03	235	147	6	EFO_0003884
Disease	Atrial Fibrillation	AKAP6 NEBL RBM20 SYNE2 PITX2	1.27e-03	160	147	5	C0004238
Disease	hearing impairment	OTOA TECTA PITX2 USH2A	1.49e-03	98	147	4	C1384666
Disease	Charcot-Marie-Tooth Disease	SETX MORC2	1.57e-03	12	147	2	C0007959
Disease	congenital hypothyroidism (biomarker_via_orthology)	GH1 GH2	2.16e-03	14	147	2	DOID:0050328 (biomarker_via_orthology)
Disease	coronary artery disease, factor VII measurement	AGPAT4 APOB ELL SMAD3	2.34e-03	111	147	4	EFO_0001645, EFO_0004619
Disease	factor VIII measurement, coronary artery disease	AGPAT4 APOB ELL SMAD3	2.50e-03	113	147	4	EFO_0001645, EFO_0004630
Disease	Malignant neoplasm of breast	AKAP6 TANK RB1 ZNF366 TECTA PRC1 PALB2 SLC2A10 AKAP9 SYNE2 ROBO1 PLD2 DNAH9	2.85e-03	1074	147	13	C0006142
Disease	von Willebrand factor measurement, coronary artery disease	AGPAT4 APOB ELL SMAD3	2.92e-03	118	147	4	EFO_0001645, EFO_0004629
Disease	obsolete_red blood cell distribution width	RALGDS OGT TTC28 ZNF366 MYO19 LARP1 APOB PRC1 TRIM59 CYFIP1 SYNE2 RNF10 ZC3H7B SLC12A7 ELL	3.03e-03	1347	147	15	EFO_0005192
Disease	urate measurement, spine bone mineral density	RBM20 ROBO1 RIC1	3.06e-03	58	147	3	EFO_0004531, EFO_0007701
Disease	Prostatic Neoplasms	RAG1 RB1 ADAMTS8 ELAC2 PALB2 LRP2 ROBO1 ZMYM3 IL6ST	3.84e-03	616	147	9	C0033578
Disease	Malignant neoplasm of prostate	RAG1 RB1 ADAMTS8 ELAC2 PALB2 LRP2 ROBO1 ZMYM3 IL6ST	3.84e-03	616	147	9	C0376358
Disease	coronary atherosclerosis measurement, traffic air pollution measurement	NEBL RARS2	4.86e-03	21	147	2	EFO_0007908, EFO_0007938

Protein segments in the cluster

Peptide	Gene	Start	Entry
ANQNCVDAYPTFLAV	ALOX5AP	56	P20292
DFNPGSLACSQLQNY	AKAP9	3856	Q99996
SLACSQLQNYDPDRA	AKAP9	3861	Q99996
NCQPTNVSEYNAAAL	AMOT	646	Q4VCS5
PLQQSQDYINLFCAN	C16orf89	216	Q6UX73
LQPQSNFCLLFDYRL	EGFL6	456	Q8IUX8
RDNPQGSFDCIQQYV	ELL	86	P55199
LPNDNGSYRCSANFQ	BTLA	106	Q7Z6A9
YDTIFQIFNNRNCLS	CASP4	231	P49662
YQQNPRDNFLSLEDC	CREBRF	51	Q8IUR6
YQLDQQCRQIFGPDF	ADAMTS8	446	Q9UP79
TPNNNGTYACFVSNL	CEACAM5	646	P06731
SIKNNYNQDRSFCRP	C14orf28	11	Q4W4Y0
FCNLFINQATAYLSP	DNAH11	391	Q96DT5
FYQFRELCEENLNPN	DLGAP1	846	O14490
RNAPFACYEEIQSQS	ADAM32	511	Q8TC27
ENLCENPYFSNLRQN	CDADC1	261	Q9BWV3
PSENLISYFNNCTVN	RB1	396	P06400
NSCPQFIQNNRGYIN	RAD51AP2	736	Q09MP3
PESLCQYSFNSQRFA	RAG1	906	P15918
NQACQEVLTPENSRY	RBM20	1096	Q5T481
LQSNIQYITRFCNPS	RABGEF1	331	Q9UJ41
YLNCGEASQTQNPRS	RIC1	431	Q4ADV7
RNLTYCTNFNNRPTE	RECK	351	O95980
PRALTEFYCQVIQFN	KBTBD3	586	Q8NAB2
NQALYSIPLVQLFAC	LTN1	1261	O94822
RNLTLFCNEFGYQND	MORC1	446	Q86VD1
QNNFALLSPYQVNCL	OTOA	606	Q7RTW8
LLYQPNFNTNFEDRN	CYFIP1	36	Q7L576
FQIQRCATDPNSYKS	SLC25A21	41	Q9BQT8
NPDLANNYKRNCATF	DCAF1	1216	Q9Y4B6
NNYKRNCATFNPTDD	DCAF1	1221	Q9Y4B6
YSQTDFSQLLNCPEF	LARP1	491	Q6PKG0
SQYCFLDFCNDPQNR	LY6G5C	131	Q5SRR4
NCFPSYNRDSNLDVI	KIAA0825	226	Q8IV33
QFYQNQRCCESNLEP	KRT85	156	P78386
FPDNSLEQLCINYAN	MYO19	421	Q96H55
FQQLTGQPNVLCYAS	SLC2A10	241	O95528
ELEFVQCLANPNYLN	MED31	21	Q9Y3C7
QCLANPNYLNFLAQR	MED31	26	Q9Y3C7
TCLANFLARLQQQAY	ATXN3L	146	Q9H3M9
LCSLQDLNLYYNNIP	LRRC36	71	Q1X8D7
NGNYSILFCTNRQLL	MINDY4B	371	A8MYZ0
QYLECQEAVFNPQSR	CUL7	1071	Q14999
DLINPGAQNISNCTY	RNASE3	111	P12724
LQVSYDCRAPNNFTI	PEG10	591	Q86TG7
DCRAPNNFTIQNQYP	PEG10	596	Q86TG7
QYPENAALQISALSC	LRRK2	301	Q5S007
LPNNGFCYLLVNESN	LY75	366	O60449
RSYLCNNLTNLEPFV	LYPD4	111	Q6UWN0
QYLCPSQQSAEDLAR	GLRB	36	P48167
LNPDNRSCSPYNSFI	LRP2	2051	P98164
CRQNSNIEPYLIFSN	LRP2	3191	P98164
NILQFLPQAASCQNY	POLE	1981	Q07864
DANDNAPVFNQSLYR	PCDHGC3	236	Q9UN70
NDNAPAFQQSSYRIS	PCDHGC4	236	Q9Y5F7
CAFSQTLQPQNRDAF	PPP4R3B	341	Q5MIZ7
AYNRVIFVQNCPDTA	MARCHF1	231	Q8TCQ1
HYFVRNSNLFQCTNP	MAB21L3	326	Q8N8X9
VGLQNLCNSYQSRAD	MORC2	956	Q9Y6X9
RRVYNFCAQDVPSAQ	SBF1	1841	O95248
NNTRCNYLFEQPSSR	PRSS41	211	Q7RTY9
SCSLNELTYNNLPAN	PALB2	326	Q86YC2
ILASQLPFCAYNEIQ	OR6N2	161	Q8NGY6
LNNYALFLSPSAQQA	APOB	3071	P04114
APFSRYQAQNFTLVC	IGSF21	156	Q96ID5
DGILPRQQYFKQNCS	IL6ST	806	P40189
YLPNCINFSARTSAN	DNAH3	2096	Q8TD57
YLLSVANNPIQSQFC	AGBL2	406	Q5U5Z8
GLCNSSSALPLYNQQ	RALGDS	781	Q12967
SSLCNPYSNTLNQNL	CEP192	1326	Q8TEP8
CVNARVNNSDPYSVA	CYBB	126	P04839
NLADRSCNDLSQYPV	NSMAF	321	Q92636
QSRATCNNYTPQFQL	KPRP	196	Q5T749
SPQLLVQAYQQCFSD	EME1	506	Q96AY2
CNLLIQQASNYLSPE	DNAH9	366	Q9NYC9
LNFFFPTTCNLRENQ	FMR1NB	126	Q8N0W7
YPAVCEFLQNNNLLS	PPP3CB	271	P16298
SQPSAACDEYFIQNN	SLC12A7	346	Q9Y666
NIISTFQNLYRCPGD	SCAF8	91	Q9UPN6
GNCYTFNNRENETIL	SCNN1G	281	P51170
FLQQLTAFFQQCPER	FOCAD	151	Q5VW36
QCYTRAIQINPAFAD	OGT	416	O15294
YPNAFICQRHNSSIN	MRC1	916	P22897
VDLNNEPNNFISTYC	RPP40	251	O75818
YLNDFNTACLQEPQS	RARS2	481	Q5T160
VNCLQLSNFTPYSRG	USH2A	436	O75445
EGNFYLRQNNSFLCL	USH2A	831	O75445
DAPESQNNCRLIAYQ	STING1	301	Q86WV6
QNNCRLIAYQEPADD	STING1	306	Q86WV6
FNALVNYTNRNAASP	SFXN2	126	Q96NB2
AQTLSCNYNQPSLDD	SYNE2	141	Q8WXH0
NYRCPIQLNEGVSFQ	RIMOC1	176	A6NDU8
CIRAYQPQISSTNYN	LAMA1	2126	P25391
YSTRDFQDCPLQKNS	GPR108	96	Q9NPR9
DQCFYSQEQRQAFAP	PRC1	306	O43663
RRCQVAFSYLPQNDD	SH3KBP1	101	Q96B97
SYSCLNPQLESNEGQ	SHISAL2A	136	Q6UWV7
ECYLSIQTQENFPAN	SETX	1856	Q7Z333
SFRPGNQECYDNFLQ	SLC12A1	61	Q13621
NSTQDNNYGCVPLLE	TANK	66	Q92844
DICFSLNNNSPNIRY	TEKT1	186	Q969V4
TCYPFVQENQSNRQF	SECISBP2L	56	Q93073
YASVQNPASNLSACQ	PITX2	296	Q99697
NPASNLSACQYAVDR	PITX2	301	Q99697
LPCQEPAQNTFYSRQ	SI	1691	P14410
RDQFSLPQNFANVCL	SLC25A43	196	Q8WUT9
FSNASQCYLCPSAQQ	PLB1	171	Q6P1J6
NQTECFNFIRFLQPY	SEMA4C	106	Q9C0C4
QPDSNCTLSIANRLY	SERPINB11	96	Q96P15
FYNQCLQLTQAARRP	PLA2G3	486	Q9NZ20
SYNNCATQLFFILLP	OR6C6	91	A6NF89
NATPKRTIRDCFNYN	AKAP6	366	Q13023
DCLQNTYNLNSVLAG	CIP2A	91	Q8TCG1
LAANAIAQSCQPSFY	CLCNKA	506	P51800
LAANAIAQSCQPSFY	CLCNKB	506	P51801
PLQADNLLTNCLFYR	C15orf39	81	Q6ZRI6
CQRFGNALAQRFQPY	ZBTB25	381	P24278
NPSNFRNFTRTCQDI	TMEM156	76	Q8N614
NQANVTCQVSNFYPR	SIRPB1	266	O00241
LAPSCNELQFSQYAA	TECTA	1661	O75443
QKYSFLQNPQTSLCF	GH2	66	P01242
RNCGNFSVYLLQPTQ	VWDE	136	Q8N2E2
PYQCNQCKQSFSQRR	ZNF189	231	O75820
SRNYFSQCQALLNRI	TTLL8	321	A6PVC2
LNIYFNCTDLNPSRE	TSPAN17	166	Q96FV3
FIQPICENATFQRYQ	ELAC2	316	Q9BQ52
RRSKNQSSFIYQPCQ	TP53INP2	201	Q8IXH6
CNFIPDNSQLEYTQE	RMC1	91	Q96DM3
SAIFVQSPNCNQRYG	SMAD3	311	P84022
DNSCLYQEIAPSFQR	SPATA8	11	Q6RVD6
LENLQQFPAFNSYTC	RNF10	636	Q8N5U6
QLPTAQRCANYISLF	TRAF6	396	Q9Y4K3
PQFSGYQQQDCQELL	USP15	371	Q9Y4E8
QKYSFLQNPQTSLCF	GH1	66	P01241
RPADCIANYNNQLDN	ROBO1	1011	Q9Y6N7
LCAPFLYLNFNNEAL	TBCK	551	Q8TEA7
AQSSNCYNRSIKQEP	TET3	1386	O43151
TIVSCNPNYRNSLLF	TAS1R2	716	Q8TE23
AVDPQNCILYSNRSA	TTC28	86	Q96AY4
SECDKTFQYPSQLQN	ZNF366	396	Q8N895
TCLQLRSQQLASFYN	USP24	1416	Q9UPU5
RSQQLASFYNLPCVA	USP24	1421	Q9UPU5
ISPNLQGNYTCLALN	VSIG10	191	Q8N0Z9
NLLGRCNYSQSERNL	ZC3HAV1	91	Q7Z2W4
PNENSYCYQLLRQLN	ZBTB10	341	Q96DT7
TLYCFSNKESPNQNN	ZBTB10	391	Q96DT7
NLYLSCFANSNPPAQ	PSG2	256	P11465
YDCTLNFRNNENPTL	AGPAT4	226	Q9NRZ5
ESNANIYEQIFRCLP	PLD2	851	O14939
YSLFNVCGSAPQQLR	WDR87	316	Q6ZQQ6
CLSNVPQLTEYFLNN	USP11	326	P51784
QCLLRFYSQQNQPNL	ZMYM3	746	Q14202
RNCLENILQASGNFY	TRIM59	31	Q8IWR1
PCYILFRLDSQNAQG	TWF1	66	Q12792
NESFYQNPNFTKCQR	ZNF487	386	B1APH4
NPYDCEQAFSQQAIS	ZFP90	476	Q8TF47
RNFPQQYDLCIHAQN	ZC3H7B	751	Q9UGR2
SCYSLANQLELNPDF	AGL	171	P35573
NCIAYNPNGNALDES	KLRD1	151	Q13241
YNPLESASFRQNQLA	NEBL	246	O76041
YTLQINPNSGLCNED	NEDD4L	691	Q96PU5