Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA uridylyltransferase activity	TUT4 TUT7	4.39e-05	3	77	2	GO:0050265
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC4A7 SLC39A8 SLC4A1	2.52e-04	32	77	3	GO:0015106
GeneOntologyMolecularFunction	nucleotidyltransferase activity	TUT4 MB21D2 POLR1A TUT7 SIRT4	3.04e-04	152	77	5	GO:0016779
GeneOntologyMolecularFunction	uridylyltransferase activity	TUT4 TUT7	3.04e-04	7	77	2	GO:0070569
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process	TUT4 TUT7 CNOT7 MRTO4 CTIF PTBP1 CNOT8	5.67e-07	132	76	7	GO:0000956
GeneOntologyBiologicalProcess	oocyte maturation	TUT4 RPS6KA2 TUT7 PABPC1L	2.69e-05	47	76	4	GO:0001556
GeneOntologyBiologicalProcess	polyuridylation-dependent mRNA catabolic process	TUT4 TUT7	4.01e-05	3	76	2	GO:1990074
GeneOntologyBiologicalProcess	transposable element silencing by mRNA destabilization	TUT4 TUT7	1.33e-04	5	76	2	GO:0141008
GeneOntologyBiologicalProcess	RNA 3' uridylation	TUT4 TUT7	1.33e-04	5	76	2	GO:0071076
GeneOntologyCellularComponent	proton-transporting two-sector ATPase complex, proton-transporting domain	ATP5PF ATP6V0A1 ATP6V0A2	1.13e-04	26	76	3	GO:0033177
GeneOntologyCellularComponent	CCR4-NOT core complex	CNOT7 CNOT8	1.94e-04	6	76	2	GO:0030015
GeneOntologyCellularComponent	spectrin	SPTBN1 PRKCB	4.62e-04	9	76	2	GO:0008091
GeneOntologyCellularComponent	vacuolar proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0A2	5.76e-04	10	76	2	GO:0000220
GeneOntologyCellularComponent	proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0A2	8.41e-04	12	76	2	GO:0033179
GeneOntologyCellularComponent	proton-transporting two-sector ATPase complex	ATP5PF ATP6V0A1 ATP6V0A2	9.49e-04	53	76	3	GO:0016469
MousePheno	abnormal pH regulation	SLC4A7 SH3GLB2 RYR1 SLC4A1	2.00e-05	42	54	4	MP:0004043
Domain	V-type_ATPase_116kDa_su_euka	ATP6V0A1 ATP6V0A2	9.24e-05	4	74	2	IPR026028
Domain	V_ATPase_I	ATP6V0A1 ATP6V0A2	9.24e-05	4	74	2	PF01496
Domain	V-ATPase_116kDa_su	ATP6V0A1 ATP6V0A2	9.24e-05	4	74	2	IPR002490
Domain	Anion_exchange	SLC4A7 SLC4A1	1.54e-04	5	74	2	IPR001717
Domain	CAF1	CNOT7 CNOT8	1.54e-04	5	74	2	PF04857
Domain	RNase_CAF1	CNOT7 CNOT8	1.54e-04	5	74	2	IPR006941
Domain	ANION_EXCHANGER_2	SLC4A7 SLC4A1	3.21e-04	7	74	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A7 SLC4A1	3.21e-04	7	74	2	PS00219
Domain	PAP_assoc	TUT4 TUT7	3.21e-04	7	74	2	PF03828
Domain	PAP_assoc	TUT4 TUT7	3.21e-04	7	74	2	IPR002058
Domain	EF-hand_8	MICU2 RYR1 CAPN11	3.27e-04	34	74	3	PF13833
Domain	Band3_cytoplasmic_dom	SLC4A7 SLC4A1	5.48e-04	9	74	2	IPR013769
Domain	Band_3_cyto	SLC4A7 SLC4A1	5.48e-04	9	74	2	PF07565
Domain	-	SLC4A7 SLC4A1	5.48e-04	9	74	2	3.40.1100.10
Domain	HCO3_cotransp	SLC4A7 SLC4A1	6.83e-04	10	74	2	PF00955
Domain	HCO3_transpt_C	SLC4A7 SLC4A1	6.83e-04	10	74	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A7 SLC4A1	6.83e-04	10	74	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A7 SLC4A1	6.83e-04	10	74	2	IPR003020
Domain	NTP_transf_2	TUT4 TUT7	8.32e-04	11	74	2	PF01909
Domain	Polymerase_NTP_transf_dom	TUT4 TUT7	8.32e-04	11	74	2	IPR002934
Domain	GPCR_3_CS	GABBR2 GRM5	1.37e-03	14	74	2	IPR017979
Domain	FA58C	DDR2 F5	3.10e-03	21	74	2	SM00231
Domain	GPCR_3	GABBR2 GRM5	3.10e-03	21	74	2	IPR000337
Domain	FA58C_3	DDR2 F5	3.10e-03	21	74	2	PS50022
Domain	FA58C_1	DDR2 F5	3.10e-03	21	74	2	PS01285
Domain	FA58C_2	DDR2 F5	3.10e-03	21	74	2	PS01286
Domain	7tm_3	GABBR2 GRM5	3.40e-03	22	74	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GABBR2 GRM5	3.40e-03	22	74	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GABBR2 GRM5	3.40e-03	22	74	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GABBR2 GRM5	3.40e-03	22	74	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GABBR2 GRM5	3.40e-03	22	74	2	PS50259
Domain	GPCR_3_C	GABBR2 GRM5	3.40e-03	22	74	2	IPR017978
Domain	zf-CCHC	TUT4 TUT7	3.71e-03	23	74	2	PF00098
Domain	F5_F8_type_C	DDR2 F5	4.04e-03	24	74	2	PF00754
Domain	FA58C	DDR2 F5	4.04e-03	24	74	2	IPR000421
Domain	-	TUT4 TUT7	4.73e-03	26	74	2	4.10.60.10
Domain	SPRY	FSD1 BTN3A1 RYR1	4.99e-03	87	74	3	SM00449
Domain	SPRY	FSD1 BTN3A1 RYR1	6.18e-03	94	74	3	PF00622
Domain	SPRY_dom	FSD1 BTN3A1 RYR1	6.18e-03	94	74	3	IPR003877
Domain	B30.2/SPRY	FSD1 BTN3A1 RYR1	6.37e-03	95	74	3	IPR001870
Domain	B302_SPRY	FSD1 BTN3A1 RYR1	6.37e-03	95	74	3	PS50188
Domain	HMGI/Y_DNA-bd_CS	PRR12 PSIP1	6.69e-03	31	74	2	IPR000637
Domain	ZF_CCHC	TUT4 TUT7	8.47e-03	35	74	2	PS50158
Domain	ANF_lig-bd_rcpt	GABBR2 GRM5	9.43e-03	37	74	2	IPR001828
Domain	Pkinase_C	RPS6KA2 PRKCB	9.43e-03	37	74	2	IPR017892
Pathway	REACTOME_DEADENYLATION_OF_MRNA	TUT4 TUT7 CNOT7 CNOT8	2.65e-06	25	56	4	M13492
Pathway	REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	TUT4 TUT7 CNOT7 CNOT8	7.03e-05	56	56	4	M839
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	ATP6V0A1 SLC4A7 PSIP1 SPTBN1 MRTO4 PTBP1 RAB11FIP1 F5 SLC39A8 RYR1	8.95e-07	604	77	10	37616343
Pubmed	Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse.	TUT4 TUT7 CNOT7	2.94e-06	13	77	3	31777931
Pubmed	The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.	TUT4 TUT7	4.84e-06	2	77	2	28665939
Pubmed	RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.	TUT4 TUT7	4.84e-06	2	77	2	34949722
Pubmed	Conservation of the deadenylase activity of proteins of the Caf1 family in human.	CNOT7 CNOT8	4.84e-06	2	77	2	15769875
Pubmed	TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication.	TUT4 TUT7	4.84e-06	2	77	2	37085578
Pubmed	TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.	TUT4 TUT7	4.84e-06	2	77	2	25979828
Pubmed	CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.	CNOT7 CNOT8	4.84e-06	2	77	2	35248544
Pubmed	Rare novel CYP2U1 and ZFYVE26 variants identified in two Pakistani families with spastic paraplegia.	CYP2U1 ZFYVE26	4.84e-06	2	77	2	32006740
Pubmed	The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.	CNOT7 CNOT8	4.84e-06	2	77	2	19605561
Pubmed	Uridylation by TUT4 and TUT7 marks mRNA for degradation.	TUT4 TUT7	4.84e-06	2	77	2	25480299
Pubmed	Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.	TUT4 TUT7	4.84e-06	2	77	2	36497000
Pubmed	From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation.	ATP6V0A1 ATP6V0A2	1.45e-05	3	77	2	12672822
Pubmed	3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.	TUT4 TUT7	1.45e-05	3	77	2	31178353
Pubmed	mRNA 3' uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome.	TUT4 TUT7	1.45e-05	3	77	2	28792939
Pubmed	Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.	TUT4 TUT7	1.45e-05	3	77	2	30122351
Pubmed	TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.	TUT4 TUT7	1.45e-05	3	77	2	36071058
Pubmed	The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.	CNOT7 CNOT8	1.45e-05	3	77	2	27605379
Pubmed	Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.	ATP6V0A1 ATP6V0A2	1.45e-05	3	77	2	10722719
Pubmed	CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.	CNOT7 CNOT8	1.45e-05	3	77	2	20065043
Pubmed	Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase.	ATP6V0A1 ATP6V0A2	1.45e-05	3	77	2	10702241
Pubmed	Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.	TUT4 TUT7	1.45e-05	3	77	2	23063654
Pubmed	The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.	CNOT7 CNOT8	1.45e-05	3	77	2	37767629
Pubmed	Genetic variation in solute carrier genes is associated with preeclampsia.	SLCO4C1 SLC4A1	1.45e-05	3	77	2	20691413
Pubmed	The a-subunit of the V-type H+-ATPase interacts with phosphofructokinase-1 in humans.	ATP6V0A1 PFKM	1.45e-05	3	77	2	12649290
Pubmed	The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.	CNOT7 CNOT8	1.45e-05	3	77	2	25944446
Pubmed	Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.	CNOT7 CNOT8	1.45e-05	3	77	2	33021411
Pubmed	Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.	CNOT7 CNOT8	2.89e-05	4	77	2	11136725
Pubmed	Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.	CNOT7 CNOT8	2.89e-05	4	77	2	11747467
Pubmed	Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.	CNOT7 CNOT8	2.89e-05	4	77	2	9820826
Pubmed	Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.	TUT4 TUT7	2.89e-05	4	77	2	28671666
Pubmed	Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.	WAPL RNF213	2.89e-05	4	77	2	18187866
Pubmed	The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.	CNOT7 CNOT8	2.89e-05	4	77	2	23236473
Pubmed	Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).	TUT4 TUT7	2.89e-05	4	77	2	22898984
Pubmed	Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation.	CNOT7 CNOT8	2.89e-05	4	77	2	20595394
Pubmed	mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.	PRKCB GRM5	2.89e-05	4	77	2	18774262
Pubmed	Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron.	ATP6V0A1 ATP6V0A2	2.89e-05	4	77	2	17595521
Pubmed	Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues.	ATP6V0A1 ATP6V0A2	2.89e-05	4	77	2	17497178
Pubmed	Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.	CNOT7 CNOT8	4.82e-05	5	77	2	21336257
Pubmed	A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis.	TUT4 TUT7	4.82e-05	5	77	2	30617251
Pubmed	The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos.	ATP6V0A1 ATP6V0A2	4.82e-05	5	77	2	35948619
Pubmed	The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.	CNOT7 CNOT8	4.82e-05	5	77	2	22977175
Pubmed	Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition.	CNOT7 CNOT8	4.82e-05	5	77	2	35390160
Pubmed	hCAF1, a new regulator of PRMT1-dependent arginine methylation.	CNOT7 CNOT8	7.22e-05	6	77	2	17264152
Pubmed	Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia.	SPTBN1 SLC4A1	7.22e-05	6	77	2	15310273
Pubmed	Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.	ATP6V0A1 ATP6V0A2	7.22e-05	6	77	2	21307348
Pubmed	Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.	CNOT7 CNOT8	7.22e-05	6	77	2	31924127
Pubmed	MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.	CNOT7 CNOT8	7.22e-05	6	77	2	20595389
Pubmed	CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.	CNOT7 CNOT8	7.22e-05	6	77	2	25038453
Pubmed	Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.	ATP6V0A1 ATP6V0A2	1.01e-04	7	77	2	20711468
Pubmed	Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification.	ATP6V0A1 ATP6V0A2	1.01e-04	7	77	2	19549681
Pubmed	Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.	CNOT7 CNOT8	1.01e-04	7	77	2	10637334
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	RNF213 PFKM PTBP1 GDI1 RYR1	1.02e-04	208	77	5	33230847
Pubmed	Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.	GABBR2 GRM5	1.34e-04	8	77	2	11850456
Pubmed	A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.	SLC4A7 PFKM	1.34e-04	8	77	2	24493630
Pubmed	Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.	PRKCB GRM5	1.34e-04	8	77	2	15894802
Pubmed	Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.	CNOT7 CNOT8	1.72e-04	9	77	2	21078877
Pubmed	Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development.	CNOT7 CNOT8	1.72e-04	9	77	2	21741365
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	TUT4 ATP6V0A1 RPS6KA2 TUT7 PRKCB TAF5 ATP6V0A2 CAPN11	2.13e-04	730	77	8	34857952
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TUT4 WAPL SLC4A7 POLR1A TUT7 RNF213 MBD3 ATL1	2.19e-04	733	77	8	34672954
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	RPS6KA2 SPTBN1 PRKCB GRM5 GDI1	2.43e-04	251	77	5	27507650
Pubmed	Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.	RPS6KA2 PRKCB	2.63e-04	11	77	2	16585392
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	TUT4 WAPL SPTBN1 SH3GLB2 MRTO4 PTBP1 RAB11FIP1 MBD3	2.65e-04	754	77	8	35906200
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SH3PXD2B RPS6KA2 SPTBN1 PRKCB TAF5 GABBR2 GRM5 GDI1 MBD3	2.76e-04	963	77	9	28671696
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	ATP6V0A1 SPTBN1 SH3GLB2 PRKCB PFKM GDI1	2.76e-04	403	77	6	30562941
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	PSIP1 SPTBN1 SLC39A8	3.10e-04	59	77	3	16083285
Pubmed	Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.	CNOT7 CNOT8	3.15e-04	12	77	2	17452450
Pubmed	Human Ccr4-Not complexes contain variable deadenylase subunits.	CNOT7 CNOT8	3.15e-04	12	77	2	19558367
Pubmed	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.	CNOT7 CNOT8	3.15e-04	12	77	2	31320642
Pubmed	Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.	GRM5 DOP1B	3.15e-04	12	77	2	23227193
Pubmed	Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.	TUT4 TUT7	3.71e-04	13	77	2	18172165
Pubmed	Structure and Roles of V-type ATPases.	ATP6V0A1 ATP6V0A2	3.71e-04	13	77	2	32001091
Pubmed	Hereditary Spastic Paraplegia Overview	CYP2U1 ZFYVE26 ATL1	3.77e-04	63	77	3	20301682
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	TUT4 PSIP1 SPTBN1 TUT7 MRPS14 PTCD2 MRTO4 PTBP1	4.17e-04	807	77	8	22681889
Pubmed	Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.	SPTBN1 MRTO4	4.33e-04	14	77	2	17082780
Pubmed	Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.	CNOT7 CNOT8	4.33e-04	14	77	2	20584987
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ATP5PF TUT4 SLC4A7 TUT7 MRPS14 SH3GLB2 RNF213 MRTO4 PFKM MICU2 ATL1	4.42e-04	1496	77	11	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PRR12 SLC4A7 POLR1A CNOT7 MRPS14 TAF5 RAB11FIP1 MICU2 MBD3 ATP6V0A2 CNOT8	4.45e-04	1497	77	11	31527615
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	ATP6V0A1 RPS6KA2 SPTBN1 PRKCB PFKM ATL1 ATP6V0A2	4.57e-04	621	77	7	22794259
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A13 CYP2U1	4.99e-04	15	77	2	29968852
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	CNOT7 CNOT8	4.99e-04	15	77	2	21981923
Pubmed	Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.	SLC4A7 PSIP1 CNOT7 ATL1	5.05e-04	165	77	4	16107646
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	WAPL SPTBN1 PTBP1 MBD3	5.65e-04	170	77	4	16159877
Pubmed	Genetic predictors of fibrin D-dimer levels in healthy adults.	ARHGEF28 F5	5.69e-04	16	77	2	21502573
Pubmed	Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.	TUT7 CTIF	5.69e-04	16	77	2	27773672
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	ATP5PF POLR1A PSIP1 LPCAT2 SPTBN1 MRPS14 PFKM PTBP1	5.73e-04	847	77	8	35235311
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SH3PXD2B SLC4A7 ARHGEF28 RPS6KA2 SPTBN1 FSD1 RAB11FIP1 DOP1B	6.37e-04	861	77	8	36931259
Pubmed	Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.	ATP6V0A1 ATP6V0A2	6.44e-04	17	77	2	33065002
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	OGFRL1 SH3PXD2B WAPL SLC4A7 SALL3 SPTBN1 TUT7 ATP6V0A2 CNOT8	6.49e-04	1084	77	9	11544199
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	POLR1A TUT7 MRPS14 MBD3 ATP6V0A2 DNAH1	8.23e-04	496	77	6	31343991
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	WAPL SPTBN1 RNF213 PFKM PTBP1	8.66e-04	332	77	5	32786267
Pubmed	Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.	ATP6V0A1 ATP6V0A2	8.96e-04	20	77	2	22982048
Pubmed	Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.	SPTBN1 SLC4A1	8.96e-04	20	77	2	18723693
Pubmed	RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.	CNOT7 CNOT8	8.96e-04	20	77	2	34887419
Pubmed	The vacuolar (H+)-ATPases--nature's most versatile proton pumps.	ATP6V0A1 ATP6V0A2	1.09e-03	22	77	2	11836511
Pubmed	Proton translocation driven by ATP hydrolysis in V-ATPases.	ATP6V0A1 ATP6V0A2	1.09e-03	22	77	2	12788495
Pubmed	Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.	ATP6V0A1 ATP6V0A2	1.09e-03	22	77	2	14580332
Pubmed	Neurotransmitter release: the dark side of the vacuolar-H+ATPase.	ATP6V0A1 ATP6V0A2	1.09e-03	22	77	2	14597263
Pubmed	Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.	ATP6V0A1 ATP6V0A2	1.09e-03	22	77	2	17662945
Pubmed	BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.	CNOT7 CNOT8	1.29e-03	24	77	2	27065194
GeneFamily	Non-canonical poly(A) polymerases	TUT4 TUT7	1.82e-04	7	54	2	1318
GeneFamily	CCR4-NOT transcription complex	CNOT7 CNOT8	4.73e-04	11	54	2	1023
GeneFamily	V-type ATPases	ATP6V0A1 ATP6V0A2	2.13e-03	23	54	2	415
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	TUT4 TUT7	2.51e-03	25	54	2	74
GeneFamily	Cytochrome P450 family 2	CYP2A13 CYP2U1	4.89e-03	35	54	2	1001
GeneFamily	Solute carriers	SLC4A7 SLCO4C1 SLC2A11 SLC39A8 SLC4A1	6.38e-03	395	54	5	752
ToppCell	facs-Spleen-nan-3m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4C1 LPCAT2 RPS6KA2 RAB11FIP1 F5	7.12e-06	156	76	5	f532ef4e92ac7661b1a8a4f2e98d80ce8d4e3655
ToppCell	facs-Spleen-nan-3m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4C1 LPCAT2 RPS6KA2 RAB11FIP1 F5	7.12e-06	156	76	5	da4f35353a84d919e683554932f110e29568df33
ToppCell	facs-Spleen-nan-3m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4C1 LPCAT2 RPS6KA2 RAB11FIP1 F5	7.12e-06	156	76	5	f1e25ff85c5f2f8555f9fb5ae5daed7ddb418fd1
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 MB21D2 ARHGEF28 CYP2U1 ATL1	1.02e-05	168	76	5	d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 WAPL TUT7 RNF213 BTN3A1	1.31e-05	177	76	5	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 WAPL TUT7 RNF213 BTN3A1	1.31e-05	177	76	5	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	TUT4 WAPL TUT7 RNF213 BTN3A1	1.31e-05	177	76	5	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TUT4 WAPL TUT7 RNF213 BTN3A1	1.31e-05	177	76	5	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TUT4 WAPL TUT7 RNF213 BTN3A1	1.31e-05	177	76	5	d5aeda113afaa2425874394610344570c9078478
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 RPS6KA2 PRKCB TAAR1 GABBR2	1.35e-05	178	76	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	Monocytes-Tissue-resident_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	OGFRL1 TUT4 SLC4A7 LPCAT2 RPS6KA2	1.99e-05	193	76	5	198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SH3PXD2B MB21D2 LPCAT2 CD53 PRKCB	2.09e-05	195	76	5	62dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OGFRL1 CD53 PRKCB FAM20A RYR1	2.20e-05	197	76	5	1c0024049db2d2c817a7f503de235b9630b24e33
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OGFRL1 LPCAT2 CD53 RNF213 RYR1	2.30e-05	199	76	5	e7faf7d0cb43cf93149c446e5f718f84fa85477c
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SH3PXD2B CD53 RNF213 PRKCB SLC39A8	2.30e-05	199	76	5	155b03b859157013e9142e9248551369127d9204
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	TUT4 SLC4A7 PSIP1 SPTBN1 RNF213	2.30e-05	199	76	5	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LPCAT2 TUT7 CD53 RNF213 RYR1	2.30e-05	199	76	5	e245851a5bddf56f7e13a7fb7c5fda2fd275dae3
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GVINP1 RAB11FIP1 F5 SLC39A8	7.49e-05	131	76	4	d5bc40cd585582856881081b7130dec3515b4ae0
ToppCell	P03-Hematopoietic\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CD53 F5 RYR1 SLC4A1	9.95e-05	141	76	4	4a856521520ea73291f4730fe94c5de88c2b6f0c
ToppCell	droplet-Fat-Scat-21m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD53 RAB11FIP1 GABBR2 RYR1	1.26e-04	150	76	4	b6e5e04aaf1c5265ac07581868d3159f9292a84c
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHST10 GDAP1 CD53 PRKCB	1.30e-04	151	76	4	ee56b88c56c3b6a5ec9644c43cae521ea0e05920
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHST10 GDAP1 CD53 PRKCB	1.30e-04	151	76	4	2c239b09970acbaa90c5ebe1097f453c516f868e
ToppCell	COVID-19_Mild\|World / 5 Neutrophil clusters in COVID-19 patients	ATP5PF WAPL TUT7 BTN3A1	1.33e-04	152	76	4	2ff0980dfd8d430cca14649151d856edef115720
ToppCell	facs-Heart-RV-24m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 LPCAT2 CD53 PRKCB	1.40e-04	154	76	4	709e7eedec11e675c6bbd55940f91dea5f715f4c
ToppCell	facs-Heart-RV-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 LPCAT2 CD53 PRKCB	1.40e-04	154	76	4	8c65d4ea787a75f20448b11beea571d7ec684721
ToppCell	facs-Heart-RV-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 LPCAT2 CD53 PRKCB	1.40e-04	154	76	4	60e7c03d91ea87eb6226a744633cbe6efa9a9928
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRR12 FANCB GABBR2 SLC4A1	1.51e-04	157	76	4	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	droplet-Kidney-nan-18m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B GVINP1 LPCAT2 PRKCB	1.51e-04	157	76	4	eb64a4e89843895d16015c7d51805f164ed7ea5b
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPCAT2 CD53 PABPC1L RAB11FIP1	1.58e-04	159	76	4	a6093b230afdd4d91870d289c6ac91d1856666a3
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GVINP1 LPCAT2 PRKCB GRAMD1C	1.62e-04	160	76	4	6393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GVINP1 LPCAT2 PRKCB GRAMD1C	1.62e-04	160	76	4	2065938e944eb99478fd8132c2c03adeaee6d447
ToppCell	droplet-Fat-Mat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 LPCAT2 CD53 RAB11FIP1	1.78e-04	164	76	4	baf6c40b004433c6b1d0bbbb74f73fcd6ee162ea
ToppCell	droplet-Fat-Mat-18m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 LPCAT2 CD53 RAB11FIP1	1.78e-04	164	76	4	a27b9b3380f29bb17c9f787423f2591f2b9cf33e
ToppCell	droplet-Fat-Mat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 LPCAT2 CD53 RAB11FIP1	1.78e-04	164	76	4	1fc64b21e97e651f88a92de51536b3753f3e08d6
ToppCell	droplet-Fat-Gat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 LPCAT2 CD53 RAB11FIP1	1.82e-04	165	76	4	c3ca2b35299294a5e3d1881fd11617e3ab720692
ToppCell	droplet-Fat-Gat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 LPCAT2 CD53 RAB11FIP1	1.82e-04	165	76	4	af32eae9324ef053f4f76e2144fb84c6e264c482
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LPCAT2 CD53 RAB11FIP1 F5	1.86e-04	166	76	4	3195035445d35d820f5e00dd03b029730478b024
ToppCell	facs-Lung-nan-3m-Epithelial-type_I_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 RAB11FIP1 GRAMD1C SLC39A8	1.86e-04	166	76	4	11b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCell	facs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 RAB11FIP1 GRAMD1C SLC39A8	1.86e-04	166	76	4	fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LPCAT2 CD53 RAB11FIP1 F5	1.86e-04	166	76	4	6b6ecd70264b6bfbd8a3a378c965702829e2ecf1
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF28 RAB11FIP1 GRAMD1C SLC39A8	1.91e-04	167	76	4	bebc2493a2ee41920b21c2b774a1c5a9619315c4
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF28 RAB11FIP1 GRAMD1C SLC39A8	1.91e-04	167	76	4	9f2661729a2d58e17a9203a563d538c08a3dbbbc
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	POLR1A LPCAT2 FSD1 ATL1	1.91e-04	167	76	4	17c653b46507c8bb85da95836ae72a6015336142
ToppCell	droplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLR1A CNOT7 RYR1 DNAH1	1.91e-04	167	76	4	f33cef917fa733adf6d5a9a9e989a4d9fd462a8f
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 LPCAT2 PABPC1L F5	2.00e-04	169	76	4	1000eaf5158596b4898bedcc802b31db76b05a48
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 LPCAT2 PABPC1L F5	2.00e-04	169	76	4	83b854fa8fd9017df8f9207d9ced260eee98e8c1
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TUT4 WAPL SPTBN1 TUT7	2.09e-04	171	76	4	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 RPS6KA2 TAAR1 GABBR2	2.23e-04	174	76	4	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	C10orf67 SPTBN1 RAB11FIP1 SLC39A8	2.23e-04	174	76	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 CD53 PRKCB RYR1	2.28e-04	175	76	4	738b3d476ac494e2e79b70b3b83bc1b7ae8396bd
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	ATP5PF TUT4 WAPL TUT7	2.28e-04	175	76	4	35ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 CD53 PRKCB RYR1	2.43e-04	178	76	4	5a4f97d19265577cfdb3e53f9dc3a9a02cfcffa9
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OGFRL1 CD53 PRKCB RYR1	2.49e-04	179	76	4	716856b2c7c660bf5ce00e63efeda6ed121f2baa
ToppCell	Severe-B_memory-3\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PSIP1 CD53 MICU2 GRAMD1C	2.54e-04	180	76	4	90b812c5450359b1745b413421b71e291c97086a
ToppCell	AT1_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	C10orf67 SPTBN1 RAB11FIP1 SLC39A8	2.54e-04	180	76	4	ff4728782c3ec814ba071cc22b7894abdd9da837
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|COVID-19_Severe / Disease condition and Cell class	ATP5PF TUT4 WAPL TUT7	2.59e-04	181	76	4	0d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell	HSPCs-Erythroblasts\|World / Lineage and Cell class	CHST10 PFKM SLC39A8 SLC4A1	2.59e-04	181	76	4	ce26f1accc8f69b7bc4b929073e975c887566c6a
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	TUT4 WAPL TUT7 RNF213	2.70e-04	183	76	4	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	C10orf67 SPTBN1 RAB11FIP1 SLC39A8	2.82e-04	185	76	4	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGEF28 LHFPL5 FSD1 GDI1	2.82e-04	185	76	4	3d6711030ca4328357b06d5497cf98cdefcd7f4f
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SH3PXD2B PRKCB FAM20A SLC39A8	2.82e-04	185	76	4	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SH3PXD2B PRKCB FAM20A SLC39A8	2.82e-04	185	76	4	780bdb63ef913a09930063286011c9108381d3a9
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SH3PXD2B PRKCB FAM20A SLC39A8	2.82e-04	185	76	4	274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SH3PXD2B PRKCB FAM20A SLC39A8	2.82e-04	185	76	4	b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLCO4C1 GVINP1 PRKCB BTN3A1	2.88e-04	186	76	4	71e87c4c755ab607689cb050f5a363cb520a0f53
ToppCell	Control-Myeloid-MoAM3,_VCAN\|Myeloid / Condition, Lineage and Cell class	SLCO4C1 SPTBN1 PRKCB FAM20A	2.88e-04	186	76	4	0bf16ac48931b62bb3c33d63ff4279654148e293
ToppCell	droplet-Liver-Npc-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GVINP1 LIX1L PFKM SLC39A8	2.88e-04	186	76	4	75258d88e23112fd1f0f7c71ef0366abb400d33e
ToppCell	droplet-Marrow-nan-21m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 PSIP1 SLC39A8 SLC4A1	2.88e-04	186	76	4	6e6998f5ccb1b2628048a21e8d3053e020569aba
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLCO4C1 RPS6KA2 FAM20A SLC39A8	2.94e-04	187	76	4	7c44cec1c26ca5907a495f2d7e633410e2e9728f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	C10orf67 SPTBN1 RAB11FIP1 SLC39A8	2.94e-04	187	76	4	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGEF28 LPCAT2 RPS6KA2 SPTBN1	2.94e-04	187	76	4	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	Control-Myeloid-MoAM1\|Control / Disease group,lineage and cell class （2021.01.30）	SH3PXD2B PRKCB FAM20A SLC39A8	3.06e-04	189	76	4	55d5c2fb9e6ab556d42c83a1e985ee66e4cf9dba
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 RAB11FIP1 SLC39A8 DNAH1	3.06e-04	189	76	4	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 RAB11FIP1 SLC39A8 DNAH1	3.06e-04	189	76	4	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	C10orf67 SPTBN1 RAB11FIP1 SLC39A8	3.12e-04	190	76	4	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	COVID-19-Heart-T_cell\|Heart / Disease (COVID-19 only), tissue and cell type	SLCO4C1 CD53 PRKCB SLC4A1	3.12e-04	190	76	4	e6c3a6e01fef6c5b49f72661d4fb0414ba9046bf
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TUT4 PTCD2 CYP2U1 TAF5	3.12e-04	190	76	4	69c5c4d5f4fb6e5ae2c9dbf9d209faf093c3f769
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	OGFRL1 MB21D2 CD53 PRKCB	3.18e-04	191	76	4	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	Dendritic_Cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	OGFRL1 SH3PXD2B SLC4A7 PRKCB	3.18e-04	191	76	4	b51c8ff1279581088557bb36760c70209c77148c
ToppCell	droplet-Marrow-BM-1m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 PFKM SLC39A8 SLC4A1	3.18e-04	191	76	4	d78d4fbb0b8317dbf14e32182466a432abef3e93
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 RPS6KA2 GDAP1 GABBR2	3.18e-04	191	76	4	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 PFKM FAM20A PRODH	3.18e-04	191	76	4	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	Control-Myeloid-MoAM3,_VCAN\|Control / Condition, Lineage and Cell class	SLCO4C1 SPTBN1 PRKCB FAM20A	3.18e-04	191	76	4	76c2fbc62855a65600cd6b8dd1e2d2c3d7415921
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 RPS6KA2 PRKCB GABBR2	3.24e-04	192	76	4	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	droplet-Marrow-BM-1m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 PSIP1 PFKM SLC39A8	3.24e-04	192	76	4	ced2fdbcb181ac250ff50cd4d5d886e568924203
ToppCell	PBMC-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	ATP5PF OGFRL1 WAPL RAB11FIP1	3.24e-04	192	76	4	41a7201febb7d88a39e4ee64df04cce18c691df8
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	SLCO4C1 RPS6KA2 FAM20A SLC39A8	3.24e-04	192	76	4	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	droplet-Marrow-BM-1m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 PSIP1 PFKM SLC39A8	3.24e-04	192	76	4	19b8675ed8a99bd3d08ad043e4ec9f006426c22f
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	SH3PXD2B PRKCB FAM20A SLC39A8	3.24e-04	192	76	4	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLCO4C1 FAM20A SLC39A8 PRODH	3.31e-04	193	76	4	136775166ecc38399091f262279180dbe5a1dcd7
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	SH3PXD2B LPCAT2 RPS6KA2 FSD1	3.31e-04	193	76	4	826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCell	Control-Myeloid-MoAM5,_CCL3L1\|Myeloid / Condition, Lineage and Cell class	SH3PXD2B PRKCB FAM20A SLC39A8	3.37e-04	194	76	4	96400477d130b2403ed81c229e4e4182cc2cdc14
ToppCell	BAL-Control-Myeloid-MoAM\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SH3PXD2B PRKCB FAM20A SLC39A8	3.37e-04	194	76	4	a4523adbbd25c314809eed3414d66a5b323446e5
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SH3PXD2B ATP6V0A1 MB21D2 PRKCB	3.37e-04	194	76	4	663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGEF28 FSD1 GDI1 ATL1	3.37e-04	194	76	4	5bd0f739aa75f387cca7c3b2686493ee2d1ee968
ToppCell	BAL-Control-Myeloid-MoAM\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SH3PXD2B PRKCB FAM20A SLC39A8	3.37e-04	194	76	4	125bf2909cf89133693bc7b865ca08955cf67a2e
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	SH3PXD2B LPCAT2 SPTBN1 DDR2	3.37e-04	194	76	4	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SH3PXD2B MB21D2 FAM20A RYR1	3.37e-04	194	76	4	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	Control-B_memory-3\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CD53 PRKCB MICU2 GRAMD1C	3.44e-04	195	76	4	135234f068da3e8db7213b53c09ed6d1d0cdc351
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ARHGEF28 GABBR2 MUC3A F5	3.44e-04	195	76	4	d3755929ebbbf5e3afde44281e9056ddb614a291
Computational	Neighborhood of PAK2	TUT7 CD53 CNOT8	1.36e-04	28	39	3	GNF2_PAK2
Drug	Fluphenazine dihydrochloride [146-56-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	CHST10 SPTBN1 CD53 PRKCB GABBR2 BTN3A1 MBD3	4.21e-06	199	75	7	7234_UP
Drug	HCNO	ATP6V0A1 SPTBN1 ATP6V0A2	7.39e-06	12	75	3	CID000521293
Disease	renal tubular acidosis (implicated_via_orthology)	ATP6V0A1 SLC4A1 ATP6V0A2	8.06e-07	8	73	3	DOID:14219 (implicated_via_orthology)
Disease	autosomal recessive osteopetrosis 1 (implicated_via_orthology)	ATP6V0A1 ATP6V0A2	6.01e-05	5	73	2	DOID:0110942 (implicated_via_orthology)
Disease	cyclic AMP-dependent transcription factor ATF-6 alpha measurement	TTC41P SLC39A8	9.00e-05	6	73	2	EFO_0801505
Disease	macrovascular complications of diabetes	RPS6KA2 F5	2.68e-04	10	73	2	EFO_0010977
Disease	sleep duration	PRR12 PRKCB PABPC1L GRM5 SLC2A11 SLC39A8	2.79e-04	362	73	6	EFO_0005271
Disease	Spastic Paraplegia, Hereditary	CYP2U1 ATL1	5.39e-04	14	73	2	C0037773
Disease	anemia (implicated_via_orthology)	SLC4A7 SLC4A1	6.21e-04	15	73	2	DOID:2355 (implicated_via_orthology)
Disease	schizophrenia (implicated_via_orthology)	TAAR1 GRM5 PRODH	6.49e-04	68	73	3	DOID:5419 (implicated_via_orthology)
Disease	schizophrenia, inflammatory bowel disease	PRKCB SLC39A8	9.00e-04	18	73	2	EFO_0003767, MONDO_0005090
Disease	Headache, HbA1c measurement	DDR2 PFKM	1.23e-03	21	73	2	EFO_0004541, HP_0002315

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLKKFFRSMAMLNNM	UGT1A3	106	P35503
FPKIFQTFRKDMSEM	ERICH6	136	Q7L0X2
RMFELLFTSSRFMQK	GRAMD1C	341	Q8IYS0
MGMSSLKLLKYVLFF	CD53	1	P19397
DKMALFMVEGTKFRS	CTIF	436	O43310
TFFFAMMLRKFKNSS	SLC4A1	581	P02730
MKMASFLAFLLLNFR	BTN3A1	1	O00481
FMFTQMVEKLGFRLT	GVINP1	236	Q7Z2Y8
RLKTMFTFFLTMDPK	CAPN11	706	Q9UMQ6
QTLFIMSEIFRKGMK	ARHGEF28	866	Q8N1W1
LAYKMMLEFFGIKLT	OGFRL1	196	Q5TC84
MEGINKTAKMQFFFR	OR10V1	1	Q8NGI7
MLMKKNASFEDFFLL	OR2J1	1	Q9GZK6
SMDLSDKTLFKYFMR	GRM5	176	P41594
TAKDFIFSMLGMVQK	MB21D2	61	Q8IYB1
TFDFRTGKMLMSKMN	MBD3	61	O95983
IMFEFDRIRNFTTMK	DDR2	271	Q16832
TLTGLKFDMKYMNFR	FSD1	231	Q9BTV5
RQLMPFFMTLNGAFK	DOP1B	2241	Q9Y3R5
SRAFKTAMFFVALGM	LHFPL5	91	Q8TAF8
QMQKIFADMQGFTFK	MUC3A	3056	Q02505
FDRNFATKMGAKAMN	PFKM	671	P08237
AFMLFRKRLGSMILA	GDAP1	336	Q8TB36
RFMLESNKGKSMLEF	LIX1L	216	Q8IVB5
KKFQGRFTMTRDMST	IGHV1-38-4	81	P0DTW3
RMKLTDFNFLMVLGK	PRKCB	336	P05771
FSQFGKMLSVKVMRD	PABPC1L	211	Q4VXU2
NKFEMRLSFKLGYEM	FANCB	116	Q8NB91
LKFLGRAMFFSMGFI	LPCAT2	111	Q7L5N7
SGFFSSMMKLLFISQ	OR6P1	151	Q8NGX9
FKLKQMFGNADMNTF	ATP5PF	76	P18859
SEFKKMLGFMSRGLE	CYP2U1	246	Q7Z449
LDFMAMGKFFKGLAS	DNAH1	1611	Q9P2D7
SLLTGMAFFKMREMF	CNOT7	231	Q9UIV1
LFGFSRKAGSFEMIM	SLC2A11	111	Q9BYW1
FRKGKSFLMDFMLRY	ATL1	76	Q8WXF7
KEFLSLLRMMLGSFQ	CYP2A13	196	Q16696
AMFSSFFLLGKTLMQ	MBTPS2	86	O43462
LGMIMASAFLFFNIK	GABBR2	491	O75899
SLLTGMAFFRMKELF	CNOT8	231	Q9UFF9
LMGMFEKRRFRKFLV	GDI1	131	P31150
KFSEMFQKDLAARAM	SALL3	1191	Q9BXA9
RGFLFKAKKVAMMTQ	RYR1	1386	P21817
FFGKNKVMMVALGRS	MRTO4	66	Q9UKD2
TSFNILMDMLFIKGK	PTCD2	166	Q8WV60
MKGNETMLDFRTSKF	TAF5	291	Q15542
SMFDLSMKDKSRNPF	RAB11FIP1	156	Q6WKZ4
FMETRFFKLLMESIK	POLR1A	1341	O95602
FSKVDMNFMRKIPTG	SLC4A7	411	Q9Y6M7
MREFVLLFMTFDEKK	F5	1766	P12259
LRFSDFGKAMFKPMR	FAM20A	226	Q96MK3
MEFLQFSKGLSFMRK	MICU2	266	Q8IYU8
GQRLFNKLMKMTFYG	PRODH	101	O43272
MDFNMKKLASDAGIF	SH3GLB2	1	Q9NR46
MKMSFALTFRSAKGR	SIRT4	1	Q9Y6E7
EMKSGFMASFLDFLK	PRR12	1276	Q9ULL5
TGEFDFLTMNQKMLK	TEX45	401	Q8NA69
GDKFRFFSMVRDLML	SPTBN1	1911	Q01082
SFKRFHMGTIKNNLM	B3GALT9	351	A8MXE2
FMFMVASKFITLTFK	CHST10	16	O43529
MMKSLQVDFGFLKQL	C10orf67	111	Q8IYJ2
STMLYNKFKNMFLVG	PSIP1	416	O75475
GFKKFVVTFMIFMAR	RNF213	2246	Q63HN8
MAAFMLGSLLRTFKQ	MRPS14	1	O60783
FRMTCKNTMKFALFT	SLCO4C1	446	Q6ZQN7
SKFFDLQMQMLDKFP	SH3PXD2B	46	A1X283
SSMFQLPSFMKALKF	STPG1	131	Q5TH74
KCRLMFFIGSFLKFM	TTC41P	816	Q6P2S7
DFSIMTEMLKKFLSF	WAPL	1151	Q7Z5K2
KMMLFGKIFQKDSSR	TAAR1	316	Q96RJ0
FLNSFKMKMSVILGI	ATP6V0A1	531	Q93050
FFERMLKMLLKTYGQ	SLC39A8	211	Q9C0K1
GLSRKMTNFIMKAFI	TUT7	1291	Q5VYS8
AGVSRKMTNFIMKAF	TUT4	1241	Q5TAX3
KMTNFIMKAFINGRK	TUT4	1246	Q5TAX3
FFQKDRKMALIQMGS	PTBP1	486	P26599
QLLFSAKMMFVKAGQ	ZFYVE26	1981	Q68DK2
FLNSFKMKMSVILGI	ATP6V0A2	546	Q9Y487
MDLSMKKFAVRRFFS	RPS6KA2	1	Q15349