Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TPCN2 CNGB1 RYR1

1.53e-0433633GO:0005217
Pubmed

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.

ANKRD13D NEDD4L WWP2

1.02e-061165334927784
Pubmed

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs.

FCGRT F8

3.44e-06265222246033
Pubmed

FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes.

FCGRT F8

1.03e-05365225905473
Pubmed

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.

WWP2 UPK3B

3.43e-05565218776082
Pubmed

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

NEDD4L WWP2

3.43e-05565217289006
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

NEDD4L WWP2

3.43e-05565215548568
Pubmed

Avidity-Based Method for the Efficient Generation of Monoubiquitinated Recombinant Proteins.

NEDD4L WWP2

3.43e-05565237010382
Pubmed

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.

NEDD4L WWP2

5.13e-05665215252135
Pubmed

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.

NEDD4L WWP2

5.13e-05665237156795
Pubmed

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

NEDD4L WWP2

5.13e-05665211748237
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

ANKRD13D FCGRT BCAS3 NUP210 RYR1

5.15e-0521465522199357
Pubmed

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

ANKRD13D NEDD4L WWP2

6.79e-054265327578003
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

SEMA6B PLXNB3 LRRC15 EPHA8

7.03e-0511765417145500
Pubmed

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.

NEDD4L WWP2

7.18e-05765231845480
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

NEDD4L WWP2

7.18e-05765211046148
Pubmed

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

NEDD4L WWP2

7.18e-05765223644597
Pubmed

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

NEDD4L WWP2

9.56e-05865211244092
Pubmed

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

NEDD4L WWP2

9.56e-05865217719543
Pubmed

ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.

TPCN2 RYR1

9.56e-05865230563862
Pubmed

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

NEDD4L WWP2

1.53e-041065225092867
Pubmed

USP11 augments TGFβ signalling by deubiquitylating ALK5.

NEDD4L WWP2

1.87e-041165222773947
Pubmed

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.

NEDD4L WWP2

1.87e-041165225963657
Pubmed

Genetic and physical mapping of the biglycan gene on the mouse X chromosome.

IDS F8

2.24e-04126528093671
Pubmed

Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin.

BIRC5 NKX6-1

2.65e-041365218599523
Pubmed

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

NEDD4L WWP2

3.08e-041465231015455
Pubmed

Defining the membrane proteome of NK cells.

G6PC3 PIK3C2A PIGK WWP2 ALDH16A1 CHD5 NUP210 CLN6 PIGO

3.11e-04116865919946888
Pubmed

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

NEDD4L WWP2

3.56e-041565223236378
Pubmed

Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

NEDD4L WWP2

3.56e-041565219144635
Pubmed

Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.

SEMA6B NRCAM

4.06e-041665222632726
Pubmed

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

NEDD4L WWP2

4.06e-041665222496338
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

NEDD4L WWP2

4.59e-041765228292929
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

KL NEDD4L NRCAM PIK3C2A BCAS3

4.86e-0434765517114649
Pubmed

Genetically distinct subsets within ANCA-associated vasculitis.

KATNAL1 F8

5.16e-041865222808956
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

NEDD4L WWP2

5.76e-041965221572392
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

NEDD4L WWP2

7.06e-042165237005481
Pubmed

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

NEDD4L WWP2

7.06e-042165229416926
Pubmed

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

NEDD4L WWP2

7.76e-042265224850914
Pubmed

TIM-1 Ubiquitination Mediates Dengue Virus Entry.

NEDD4L WWP2

8.48e-042365229742433
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MON2 NEDD4L NRCAM DENND4B PLXNB3

9.94e-0440765512693553
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ANKRD13D MON2 SEMA6B PSME4 BCAS3 CHD5 KIFC2 RYR1

1.03e-03110565835748872
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

NEDD4L WWP2

1.09e-032665226949039
Pubmed

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.

PSME4 CHD5

1.35e-032965227649575
Pubmed

DNA-binding specificities of human transcription factors.

VENTX IRF3

1.54e-033165223332764
Pubmed

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.

BIRC5 NKX6-1

1.65e-033265230487608
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

DUSP23 TPCN2 BCAS3 ALDH16A1 IRF3 GLB1L2 FBXL6

1.68e-0392565728986522
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

NRCAM CHD5

1.75e-033365222357600
Cytoband16q22.1

WWP2 CES4A ZDHHC1

5.25e-0411065316q22.1
CytobandXq28

IDS F8 PLXNB3

2.03e-03176653Xq28
CytobandEnsembl 112 genes in cytogenetic band chr16q22

WWP2 CES4A ZDHHC1

2.27e-03183653chr16q22
Cytoband19q13.1

ZBTB32 RYR1

2.79e-035565219q13.1
CytobandEnsembl 112 genes in cytogenetic band chrXq28

IDS F8 PLXNB3

3.48e-03213653chrXq28
Cytoband2q11.2

SLC9A2 FAM178B

4.73e-03726522q11.2
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B ROBO4 KL DUSP23 F8 ARHGEF15 DIPK2B

9.36e-09183657a644258ba90acc62d571623e429d72ffc4b69203
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

SEMA6B KL NRCAM F8 ARHGEF15 DIPK2B

2.32e-07177656f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

ROBO4 ATG9B PIK3C2A F8 ARHGEF15 DIPK2B

3.63e-07191656c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

4.22e-071966567cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

4.22e-071966564cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

4.22e-07196656d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B ROBO4 ATG9B F8 ARHGEF15 DIPK2B

4.62e-07199656e2d5c5cab102e67b0131b02392d81adaedc15965
ToppCellwk_08-11-Endothelial-Blood_vessel_endothelial-Venous_endo|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 DUSP23 ARHGEF15 DIPK2B

6.42e-06179655040a7e916baaf81f44339dc721ab2afcd2c22388
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATG9B PIK3C2A F8 ARHGEF15 DIPK2B

7.14e-06183655ff95382cfed592190d0636d2b750328471f82e0d
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

7.73e-061866550cc7504297fd0c97ea50e4b3ff58fcedc4c1cfaa
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

7.93e-0618765529b2e2be26a9d72b154760e47acf61cfe2f45fa7
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

8.14e-06188655b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

8.14e-06188655b294d6658e79328bd6fa33223e8c70117ba9789b
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

8.35e-061896554bc3826e0515b3cf2e2ef72a7b2cf9c32ade1812
ToppCell(2)_5-FU-(1)_VE-Cad+_vascular_cells|World / Stress and Cell class

SEMA6B ROBO4 FCGRT F8 ARHGEF15

8.57e-061906556b391b8a3ffcbdec3acaf242bc52fc3fc9da77c8
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

8.57e-06190655141266bf411ea675fbf889b20c1b08673c45ff95
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

8.57e-061906557ba2be2630183df86de21689289a8620a4cd507e
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

8.79e-06191655edfd5eeff69b5de19c5df3d899e42acd7e015913
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

8.79e-06191655e3fc5c92491b6e334abffbf085c00a0b5fa1aed2
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

9.01e-061926558a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

9.24e-06193655d338a7c0585b69947c37f44aa0381619493e31ea
ToppCellPCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ROBO4 KL BIRC5 ARHGEF15 DIPK2B

9.24e-06193655643f992dbce639e7d147924d8b8f455fcebf215a
ToppCellPCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating3_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

9.24e-06193655f7e4a390921780587b9bd084e495e646fa1ec74f
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

9.24e-06193655e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 PIK3C2A ARHGEF15 DIPK2B

9.24e-06193655287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCell356C-Endothelial_cells-Endothelial-A_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 KL F8 ARHGEF15 DIPK2B

9.48e-061946552e5b195e02dcd5e9432b9a98b22e0478e65b9ba2
ToppCellPCW_05-06-Endothelial|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

9.48e-0619465500291c62795a55a7e63b1db10c139d6a3298e55e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

9.48e-0619465574a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell356C-Endothelial_cells-Endothelial-A_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 KL F8 ARHGEF15 DIPK2B

9.48e-06194655b6b5b0ab506b05a005ba8a05a3c7f4c725ba9200
ToppCell(4)_Endothelial_cells-(42)_EC-sinusoidal|World / Cell class and subclass of bone marrow stroma cells in homeostatis

SEMA6B ROBO4 DUSP23 FCGRT F8

9.48e-061946554428b472c2042f88eae028b1770767512a515b75
ToppCellPCW_05-06-Endothelial-Endothelial_cycling|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

9.48e-06194655eb279e0d922de921343f0ae032a809f837d915b3
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

9.72e-06195655fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 ATG9B PIK3C2A DIPK2B

9.72e-06195655818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellPCW_07-8.5-Endothelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

9.72e-06195655f2cc94d5e1652203ca38bea57f37d3deec73ef04
ToppCell(6)_Endothelial-D|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ROBO4 DUSP23 F8 ARHGEF15 DIPK2B

9.72e-06195655c0005a5f2dc63a0cc254c45ac89a2f42df6f8bde
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

9.72e-06195655c7abcb674e4a25a5354c4947fffd0d17bc8c1fab
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA6B ROBO4 KL ARHGEF15 DIPK2B

9.72e-06195655804b7c44aaaf8ba77e36f377955df261e92f5ff9
ToppCellPCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ROBO4 KL BIRC5 ARHGEF15 DIPK2B

9.96e-06196655b826dce5b3daa8eb3d4a530b9564de58d9ce3767
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

9.96e-0619665522767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

9.96e-06196655adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

9.96e-06196655b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Neuronal-GABAergic_neurons|GW08 / Sample Type, Dataset, Time_group, and Cell type.

TPCN2 UPK3B CLN6 MAP3K15 SP140

1.02e-05197655e1a80c1aa7f7e83f5d19a40fe37db5c5a6c25685
ToppCell368C-Endothelial_cells-Endothelial-A_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 DUSP23 F8 ARHGEF15 DIPK2B

1.02e-051976557caa2c86dc4d50b57a7db8f7278d1588282ad6db
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_capillary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.02e-0519765531bec97c3952c48031bd66a5dad16a70a61519c3
ToppCell368C-Endothelial_cells-Endothelial-A_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 DUSP23 F8 ARHGEF15 DIPK2B

1.02e-05197655951f18f326967206adbbfc422cce9eea3d2e0854
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.02e-05197655e8e879b7634a29569061d3515d180784094a31e7
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.02e-05197655ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ROBO4 KL DUSP23 ARHGEF15 DIPK2B

1.02e-051976557a1a3839b2c965136663241b0d4e96c64cfb656a
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.02e-05197655f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.05e-051986551378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.05e-05198655451003a21162eeae90739fdb502bb50b362d80c8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.05e-05198655440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell(6)_Endothelial-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ROBO4 KL F8 ARHGEF15 DIPK2B

1.05e-05198655a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.05e-05198655259fbcc0f2ac281a3e4d693de45b986fe5e24841
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.07e-051996558b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.07e-0519965533f1669eeb701986b4dec409efdb6c06c3c41c2b
ToppCellproximal-Endothelial|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655970dac1b11ae8f4adb26634717064289967b4bde
ToppCellParenchyma_COVID-19-Endothelial-TX-Capillary|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ROBO4 KL F8 ARHGEF15 DIPK2B

1.10e-052006556c0498a5868891e8e22c03469d00669b20249b1a
ToppCellcellseq2-Endothelial|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-0520065581bdf7a1ddc3e82b96526449e662cca26d7297b1
ToppCellproximal-3-Endothelial|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-0520065590c36cfb9632a3bdc9a335b2193f6b08aba35208
ToppCellproximal-Endothelial-Bronchial_Vessel_2-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655b6666ade237c39bfde13987685567bad1762baec
ToppCellproximal-Endothelial-Bronchial_Vessel_2|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-052006552ecf7a38799c151ffb09f2677e38a4ffa354c1da
ToppCellParenchyma_COVID-19-Endothelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.10e-05200655abcbd5a156aa4fd51d284441388975c81c0b88ae
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655147ceed692655f4ed73b8a57b0b3224def1f3055
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Capillary-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ROBO4 KL F8 ARHGEF15 DIPK2B

1.10e-052006557020045b933cb104fb99b79524cb0d4734b8636d
ToppCellLung_Parenchyma-Severe-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.10e-05200655d9d0ffa18e5b4647966e19ad9830cbba6120677e
ToppCellproximal-Endothelial-Bronchial_Vessel_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655d034bd210c87b704acf45f50d888497c8737011b
ToppCellcellseq2-Endothelial-Endothelial_Vascular|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655dc244a5ccec1b793dc4371fb2cd2c3fd4226283e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-052006552e47888e041ec3d265425d1df97b6665c6da889c
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Capillary|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ROBO4 KL F8 ARHGEF15 DIPK2B

1.10e-05200655e9913511a129bb3cee85e7ebf565b951dab91542
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ROBO4 PIK3C2A F8 ARHGEF15 DIPK2B

1.10e-05200655e9d5ba140cabae11c437012d519b85f5412dcc94
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-0520065550fa0f8a3e490d5941b34e66a10158eba6c909d4
ToppCellproximal-3-Endothelial-Bronchial_Vessel_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-052006550ff4185021ec84b57be13b28495e2f8a4d195eb6
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-052006550afc7a0f87eac48f772759c3b626758089733361
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655310c75e13be9194312a8b686804edcf13d44caf5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate|GW23 / Sample Type, Dataset, Time_group, and Cell type.

MAP3K15 GLB1L2 CNGB1 F8 FBXL6

1.10e-05200655fe772d98c461c973dfc082e1fc50117c27ced804
ToppCellproximal-Endothelial-Bronchial_Vessel_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655e4f6e0b9502eb531f28d605f9dbda6a72a9ed320
ToppCellproximal-3-Endothelial-Bronchial_Vessel_2|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B ROBO4 F8 ARHGEF15 DIPK2B

1.10e-05200655038812912bb9f6c1359765614bb9fd138843a306
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high|E18.5-samps / Age Group, Lineage, Cell class and subclass

ROBO4 UPK3B KATNAL1 DIPK2B

7.60e-05154654212c340a096a3a9669d1aebd61c045cf1402a868
ToppCellAdult-Immune-mast_cell-D175|Adult / Lineage, Cell type, age group and donor

ZBTB32 NRCAM CHD5 SP140

8.60e-051596549f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCellCOVID-19-kidney-Epithelial_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

ROBO4 F8 ARHGEF15 DIPK2B

8.81e-051606540d4880f85565d8c540c94a8f8109147b3029279a
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TPCN2 FCGRT HACD4 NFAM1

9.02e-051616545a8698790f9aba796dd2b64af419055c60bd7de8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 F8 ARHGEF15 DIPK2B

9.24e-05162654c399b9e4854916a59f5cae2d8dbf19660f8759be
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 BIRC5 KBTBD12 F8

9.24e-05162654a957c7e347189b72fbd47db3075bb5e879a21c67
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 F8 ARHGEF15 DIPK2B

9.24e-05162654a291248b693c771845174393934a782f1d8bd7ce
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ROBO4 BIRC5 F8 ARHGEF15

9.46e-051636543efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCelldroplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATG9B HACD4 IDS NFAM1

9.92e-05165654354978d4f35154d7b2e36e94de669e045adef512
ToppCellTCGA-Lung-Solid_Tissue_Normal|TCGA-Lung / Sample_Type by Project: Shred V9

ROBO4 UPK3B GDF10 ARHGEF15

1.02e-04166654a8ebdd3cb7f59b3feeaacda45ce6d40d10db556f
ToppCellTCGA-Lung-Solid_Tissue_Normal-Lung|TCGA-Lung / Sample_Type by Project: Shred V9

ROBO4 UPK3B GDF10 ARHGEF15

1.02e-04166654c64971c27cb445dffc5a636d4b6a60261b93a2db
ToppCellTCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue|TCGA-Lung / Sample_Type by Project: Shred V9

ROBO4 UPK3B GDF10 ARHGEF15

1.02e-041666542f3072a7af048f184d33065fdd36153fd563155a
ToppCellTCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue-6|TCGA-Lung / Sample_Type by Project: Shred V9

ROBO4 UPK3B GDF10 ARHGEF15

1.02e-04166654188f2575511f418216874aed9118aa6f165252cb
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

UPK3B NKX6-1 PLXNB3 LRRC15

1.04e-04167654743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

UPK3B NKX6-1 PLXNB3 LRRC15

1.04e-041676541adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BIRC5 HACD4 NFAM1 PIGO

1.06e-041686544c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCellfacs-Trachea-nan-24m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC9A2 KL FAM178B KIFC2

1.06e-041686546c7b490b6c844d0ea4c07edfc24c02284f9533c4
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC9A2 KL GLB1L2 KIFC2

1.09e-04169654d382a76d85875663502cc7dde2e3e0682605768e
ToppCelldroplet-Fat-Gat-18m-Lymphocytic-B_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB32 KBTBD12 RYR1 SP140

1.11e-041706545185187ecf26b4c9eaa0c01ad52697ab8d075cc7
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP3K15 NFAM1 PLXNB3 RYR1

1.11e-041706548e774af244cfe787fa0ea2b6be0c3c2d00bfe4fc
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP3K15 NFAM1 PLXNB3 RYR1

1.11e-04170654f5140eb9313c0d1bb31f8a761d9c062c56733a61
DiseaseLiddle syndrome (implicated_via_orthology)

NEDD4L WWP2

2.77e-054642DOID:0050477 (implicated_via_orthology)
Diseasecorpus callosum central volume measurement

SLC9A2 PIGO

1.69e-0328642EFO_0010296
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

C5orf67 NEDD4L FCGRT KIFC2

1.82e-03239644EFO_0010934

Protein segments in the cluster

PeptideGeneStartEntry
VLEPRPPGKRWMVAG

PTRH1

21

Q86Y79
MGAPTLPPAWQPFLK

BIRC5

1

O15392
MAGPGPTFPLHRLVW

ANKRD13D

1

Q6ZTN6
RWTEPPAPFMVGLPG

CHD5

476

Q8TDI0
AGWEPMGVIGLILPP

ALDH16A1

161

Q8IZ83
DMQRWLGAFPTPGPL

ARHGEF15

731

O94989
LNLMWLPKPPGRGVA

FBXL6

336

Q8N531
ILLQIFPGAEGWPLP

DIPK2B

221

Q9H7Y0
PGPNMNPIALGSRWL

BCAS3

226

Q9H6U6
PMPWLVLSEIFPGGI

SLC2A12

481

Q8TD20
EMLFEGGPRPWILEP

NUP210

661

Q8TEM1
IGLPPPIIFWMDNSF

NRCAM

171

Q92823
MGPLALPAWLQPRYR

HACD4

1

Q5VWC8
MGLLGPLDWLGHPPQ

G6PC3

291

Q9BUM1
MALAPPPRGLWQAKD

GDF10

191

P55107
MGVPRPQPWALGLLL

FCGRT

1

P55899
APVMARWPPFGLCLL

PLXNB3

16

Q9ULL4
IFPLWKLPGFPNRMV

PIK3C2A

1476

O00443
PQLPVMVWFPGGAFI

CES4A

131

Q5XG92
AKPRPPWMGLLGPTI

F8

81

P00451
PGWPLVLGVMGAIRN

MON2

901

Q7Z3U7
PPGGFILGLWALIIM

PIGK

366

Q92643
LAVIGGPPFWQSMIP

CEPT1

226

Q9Y6K0
PDPGGLFPWSLRLMM

C5orf67

46

F2Z3F1
MAPARGRLPPALWVV

EPHA8

1

P29322
GPEPLPWLGKMAQLG

INTS14

356

Q96SY0
RWGDLGPGSVPLLPM

ATG9B

16

Q674R7
RLPRNLNPGMWGPAV

DENND4B

181

O75064
ALWQPMAPNQGLPRL

KL

636

Q9UEF7
GGLPSWLLQDPGMRL

GLB1L2

146

Q8IW92
MPPPRTGRGLLWLGL

IDS

1

P22304
LVPGRVMRPLGGQLW

SCO1

6

O75880
ERKPNPPPGLLTWLM

RYR1

4756

P21817
SLMRDLLLHWGPGPP

KIFC2

251

Q96AC6
MDPRLPAWALVLLGP

INSL3

1

P51460
FWREGPPMPSPLLSL

KBTBD12

526

Q3ZCT8
RTLPGWPVTLPDPGM

IRF3

236

Q14653
PNWDNILGPLCMPLV

MAP3K15

211

Q6ZN16
LMLGLPAQQVGPWLG

RSAD1

196

Q9HA92
GIRRPWKGVLMVGPP

KATNAL1

236

Q9BW62
PGIFGPMPNLRELWL

LRRC15

286

Q8TF66
ELPGRTPIFWPGVMQ

NKX6-1

196

P78426
MWPRLPGAGLAPQLR

FAM178B

1

Q8IXR5
MENQPVRWRALPGLP

NFAM1

1

Q8NET5
FPPWAELLGILMGLL

SLC6A7

531

Q99884
RLGRGMPPWPPDSQI

ROBO4

971

Q8WZ75
RPPLQWGKGLMELLP

ADPRH

186

P54922
GRPIAMLVFPLEWFP

CLN6

61

Q9NWW5
MLGWVQRVLPQPPGT

CNGB1

1

Q14028
AGRFPPWLVGLMGTI

PEX11G

206

Q96HA9
PPEALLAPLMQNGWA

SEMA6B

676

Q9H3T3
RTQGMIQEPALPPGW

WWP2

436

O00308
MEPLGNWRSLRAPLP

SLC9A2

1

Q9UBY0
GRWFPEGPTHMLPLL

PSME4

471

Q14997
PGASVQLPMWLRGPD

TRAPPC8

1026

Q9Y2L5
SPEPPMLFVRWGLPL

PIGO

696

Q8TEQ8
LRWLMENGFLPDPPR

SP140

651

Q13342
VGGQPALWSILLMPP

ZBTB32

256

Q9Y2Y4
ALWSILLMPPRYGIP

ZBTB32

261

Q9Y2Y4
PNGRLELGWQMPPAP

ZNF831

751

Q5JPB2
QPQPLAWPLCMGLGE

UPK3B

301

Q9BT76
PHPGWRPEMVGLLSL

TPCN2

526

Q8NHX9
GPQALMLPPGSFWGL

VENTX

191

O95231
RSPLLLLAMWGPQAP

ZDHHC1

371

Q8WTX9
MGVQPPNFSWVLPGR

DUSP23

1

Q9BVJ7
PGWEMRIAPNGRPFF

NEDD4L

501

Q96PU5