Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD4 RGPD2 KALRN RGPD1 SBF1 RALBP1 TBC1D1 RGPD3 NPRL3 SGSM3 HERC2 AGAP4 AGAP6 ACAP3 RAPGEFL1

1.80e-0650713515GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD4 RGPD2 KALRN RGPD1 SBF1 RALBP1 TBC1D1 RGPD3 NPRL3 SGSM3 HERC2 AGAP4 AGAP6 ACAP3 RAPGEFL1

1.80e-0650713515GO:0030695
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 RGPD2 RGPD1 RALBP1 TBC1D1 RGPD3 NPRL3 SGSM3 AGAP4 AGAP6 ACAP3

3.15e-0627913511GO:0005096
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD2 RGPD1 RGPD3

8.90e-06201354GO:0061665
GeneOntologyMolecularFunctionsmall GTPase binding

RGPD4 RGPD2 CIB1 RGPD1 TRIOBP WHAMM RALBP1 RGPD3 GCC1 SGSM3

6.70e-0532113510GO:0031267
GeneOntologyMolecularFunctionenzyme regulator activity

RGPD4 RGPD2 COL7A1 CIB1 ERCC6 KALRN TFPI2 CIP2A RGPD1 APC ELFN2 SBF1 RALBP1 TBC1D1 RGPD3 NPRL3 PPME1 SGSM3 HERC2 AGAP4 AGAP6 ACAP3 RAPGEFL1

7.53e-05141813523GO:0030234
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD2 RGPD1 RGPD3

9.95e-05361354GO:0019789
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-7 ERVK-21 ERVK-9 ERVK-24

1.11e-04371354GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-7 ERVK-21 ERVK-9 ERVK-24

1.23e-04381354GO:0070001
GeneOntologyMolecularFunctionGTPase binding

RGPD4 RGPD2 CIB1 RGPD1 TRIOBP WHAMM RALBP1 RGPD3 GCC1 SGSM3

1.72e-0436013510GO:0051020
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD2 RGPD1 RGPD3

3.62e-04501354GO:0003755
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

4.48e-0451352GO:0140444
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD2 RGPD1 RGPD3

4.53e-04531354GO:0016859
GeneOntologyMolecularFunctionphosphatase inhibitor activity

CIP2A ELFN2 SBF1 PPME1

4.86e-04541354GO:0019212
GeneOntologyMolecularFunctionhistone H4K20 monomethyltransferase activity

KMT5C PRDM6

6.69e-0461352GO:0140944
GeneOntologyMolecularFunctionbiotin binding

MCCC1 PC

6.69e-0461352GO:0009374
GeneOntologyMolecularFunctionligase activity, forming carbon-carbon bonds

MCCC1 PC

9.32e-0471352GO:0016885
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RGPD4 RGPD2 UBE3B RGPD1 RFFL FBXL22 RGPD3 HERC2 RNF138

1.56e-033981359GO:0061659
GeneOntologyMolecularFunctionenzyme activator activity

RGPD4 RGPD2 ERCC6 RGPD1 RALBP1 TBC1D1 RGPD3 NPRL3 SGSM3 AGAP4 AGAP6 ACAP3

1.67e-0365613512GO:0008047
GeneOntologyMolecularFunctionhistone H4K20 methyltransferase activity

KMT5C PRDM6

1.97e-03101352GO:0042799
GeneOntologyMolecularFunctionacyltransferase activity

RGPD4 RGPD2 OGT UBE3B RGPD1 RFFL PLA2G4E FBXL22 RGPD3 HERC2 WDSUB1 EP300 RNF138

2.31e-0377513513GO:0016746
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD2 RGPD1 RGPD3

2.22e-0791364GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD2 RGPD1 RGPD3

3.68e-07101364GO:1903301
GeneOntologyBiologicalProcessgluconeogenesis

RGPD4 RGPD2 OGT RGPD1 PER2 RGPD3 PC EP300

7.25e-071111368GO:0006094
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD4 RGPD2 OGT RGPD1 PER2 RGPD3 PC EP300

9.50e-071151368GO:0019319
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD2 RGPD1 RGPD3

1.23e-06131364GO:0033131
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD4 RGPD2 OGT RGPD1 PER2 RGPD3 PC EP300

1.40e-061211368GO:0046364
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD2 RGPD1 RGPD3

1.72e-06141364GO:1903299
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD4 RGPD2 OGT RGPD1 RGPD3 EP300

7.41e-06711366GO:0006111
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD2 RGPD1 RGPD3

8.07e-06201364GO:0006607
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RGPD2 RGPD1 RGPD3

1.12e-04381364GO:0000413
GeneOntologyBiologicalProcessglucose metabolic process

RGPD4 RGPD2 OGT RGPD1 PER2 RGPD3 PC EP300

2.19e-042441368GO:0006006
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD4 RGPD2 OGT RGPD1 PER2 RGPD3 PC EP300

2.38e-042471368GO:0016051
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD4 RGPD2 OGT RGPD1 RGPD3 EP300

2.44e-041321366GO:0043255
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD4 RGPD2 OGT RGPD1 RGPD3 EP300

2.65e-041341366GO:0010906
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD2 RGPD1 RGPD3 MAD1L1

8.67e-08181365GO:0044615
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD2 RGPD1 RGPD3

1.18e-0781364GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD2 RGPD1 RGPD3

3.49e-07101364GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD2 RGPD1 RGPD3

1.63e-06141364GO:0005642
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD2 RGPD1 RGPD3

7.66e-06201364GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD2 RGPD1 RGPD3

9.41e-06211364GO:0106068
GeneOntologyCellularComponentperinuclear region of cytoplasm

RGPD4 EXOC6 RGPD2 CIB1 KALRN SYNE1 ICA1 RGPD1 HIP1R APC GOLGA6B PER2 SBF1 RGPD3 FGFR3 CX3CL1 MYO16

1.21e-0493413617GO:0048471
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD2 RGPD1 RGPD3 MAD1L1

5.20e-041011365GO:0005643
MousePhenoaneuploidy

RGPD4 RGPD2 RGPD1 APC RGPD3 MAD1L1 CEP135

3.45e-07611057MP:0004024
MousePhenoabnormal chromosome number

RGPD4 RGPD2 RGPD1 APC RGPD3 MAD1L1 CEP135

3.64e-06861057MP:0004023
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD2 RGPD1 RGPD3

5.10e-06161054MP:0003701
MousePhenoincreased hepatocellular carcinoma incidence

RGPD4 RGPD2 RGPD1 APC RGPD3 MAD1L1

1.38e-05701056MP:0003331
MousePhenoabnormal morula morphology

RGPD4 RGPD2 RGPD1 RGPD3

3.96e-05261054MP:0012058
MousePhenoabnormal chromosome morphology

RGPD4 RGPD2 RGPD1 APC RGPD3 MAD1L1 CEP135

4.48e-051261057MP:0003702
MousePhenopoor grooming

SYNE1 UBE3B NOX3

4.76e-05101053MP:0001443
MousePhenoabnormal mitosis

RGPD4 RGPD2 RGPD1 RGPD3 MAD1L1 CEP135 PCNT

4.95e-051281057MP:0004046
MousePhenodecreased tumor latency

RGPD4 RGPD2 RGPD1 RGPD3

7.09e-05301054MP:0010308
MousePhenoabnormal cell nucleus morphology

RGPD4 RGPD2 RGPD1 APC RGPD3 SYNE2 MAD1L1 CEP135

7.27e-051841058MP:0003111
MousePhenofailure of blastocyst formation

RGPD4 RGPD2 RGPD1 RGPD3

8.09e-05311054MP:0012129
MousePhenoincreased sarcoma incidence

RGPD4 RGPD2 RGPD1 APC RGPD3 MAD1L1

1.17e-041021056MP:0002032
MousePhenoabnormal tumor latency

RGPD4 RGPD2 RGPD1 RGPD3

1.17e-04341054MP:0010307
MousePhenoincreased hepatobiliary system tumor incidence

RGPD4 RGPD2 RGPD1 APC RGPD3 MAD1L1

1.86e-041111056MP:0010297
MousePhenoincreased liver tumor incidence

RGPD4 RGPD2 RGPD1 APC RGPD3 MAD1L1

1.86e-041111056MP:0008019
MousePhenoabnormal blastocyst formation

RGPD4 RGPD2 RGPD1 RGPD3

2.02e-04391054MP:0012128
MousePhenoincreased lung carcinoma incidence

RGPD4 RGPD2 RGPD1 RGPD3 MAD1L1

2.97e-04781055MP:0008714
MousePhenoincreased incidence of induced tumors

RGPD4 RGPD2 ERCC6 RGPD1 APC PER2 RGPD3

3.24e-041731057MP:0002021
Domain-

RGPD4 RGPD2 RGPD1 RGPD3 GCC1

3.56e-091012951.10.220.60
DomainGrip

RGPD4 RGPD2 RGPD1 RGPD3 GCC1

6.50e-09111295SM00755
DomainGRIP

RGPD4 RGPD2 RGPD1 RGPD3 GCC1

6.50e-09111295PF01465
DomainGRIP_dom

RGPD4 RGPD2 RGPD1 RGPD3 GCC1

1.11e-08121295IPR000237
DomainGRIP

RGPD4 RGPD2 RGPD1 RGPD3 GCC1

1.11e-08121295PS50913
DomainRab_bind

RGPD4 RGPD2 RGPD1 RGPD3

7.48e-0871294PF16704
DomainGCC2_Rab_bind

RGPD4 RGPD2 RGPD1 RGPD3

7.48e-0871294IPR032023
DomainRan_BP1

RGPD4 RGPD2 RGPD1 RGPD3

1.03e-06121294PF00638
DomainRANBD1

RGPD4 RGPD2 RGPD1 RGPD3

1.03e-06121294PS50196
DomainRanBD

RGPD4 RGPD2 RGPD1 RGPD3

1.48e-06131294SM00160
DomainRan_bind_dom

RGPD4 RGPD2 RGPD1 RGPD3

1.48e-06131294IPR000156
Domain-

RGPD4 RGPD2 KALRN RGPD1 TRIOBP TEC SBF1 TBC1D1 RGPD3 AGAP4 AGAP6 ACAP3

1.73e-05391129122.30.29.30
DomainPH_dom-like

RGPD4 RGPD2 KALRN RGPD1 TRIOBP TEC SBF1 TBC1D1 RGPD3 AGAP4 AGAP6 ACAP3

4.01e-0542612912IPR011993
Domainzf-C2H2

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6

8.86e-0569312915PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6

9.01e-0569412915IPR013087
DomainZnf_C2H2-like

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6 RNF138

1.21e-0479612916IPR015880
DomainZnf_C2H2

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6 RNF138

1.37e-0480512916IPR007087
DomainZnF_C2H2

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6 RNF138

1.43e-0480812916SM00355
DomainIQ

MYH13 MYH7B UBE3B SPATA17 MYO16

2.45e-04811295SM00015
Domain-

ZNF142 ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6

2.54e-04679129143.30.160.60
DomainKASH

SYNE1 SYNE2

2.81e-0441292IPR012315
DomainKASH

SYNE1 SYNE2

2.81e-0441292PS51049
DomainKASH

SYNE1 SYNE2

2.81e-0441292SM01249
DomainKASH

SYNE1 SYNE2

2.81e-0441292PF10541
DomainZINC_FINGER_C2H2_2

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6

2.99e-0477512915PS50157
DomainZINC_FINGER_C2H2_1

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6

3.07e-0477712915PS00028
DomainIQ_motif_EF-hand-BS

MYH13 MYH7B UBE3B SPATA17 MYO16

4.00e-04901295IPR000048
DomainIQ

MYH13 MYH7B UBE3B SPATA17 MYO16

4.65e-04931295PS50096
DomainBiotin_BS

MCCC1 PC

4.67e-0451292IPR001882
DomainBiotin_COase_C

MCCC1 PC

4.67e-0451292IPR005482
DomainBC

MCCC1 PC

4.67e-0451292PS50979
DomainBiotin_carb_C

MCCC1 PC

4.67e-0451292SM00878
DomainBiotin_carb_C

MCCC1 PC

4.67e-0451292PF02785
DomainBiotin_carboxylation_dom

MCCC1 PC

4.67e-0451292IPR011764
DomainBIOTIN

MCCC1 PC

4.67e-0451292PS00188
DomainSpectrin

KALRN SYNE1 SYNE2

5.15e-04231293PF00435
DomainRudment_hybrid_motif

MCCC1 PC

6.97e-0461292IPR011054
DomainCbamoylP_synth_lsu-like_ATP-bd

MCCC1 PC

9.72e-0471292IPR005479
DomainBC-like_N

MCCC1 PC

9.72e-0471292IPR005481
DomainCPSase_L_D2

MCCC1 PC

9.72e-0471292PF02786
DomainBiotin_carb_N

MCCC1 PC

9.72e-0471292PF00289
DomainTPR_REGION

RGPD4 RGPD2 OGT RGPD1 RGPD3 CFAP46

1.01e-031651296PS50293
DomainTPR

RGPD4 RGPD2 OGT RGPD1 RGPD3 CFAP46

1.01e-031651296PS50005
DomainArfGap

AGAP4 AGAP6 ACAP3

1.03e-03291293SM00105
DomainARFGAP

AGAP4 AGAP6 ACAP3

1.03e-03291293PS50115
DomainArfGap

AGAP4 AGAP6 ACAP3

1.03e-03291293PF01412
DomainSpectrin_repeat

KALRN SYNE1 SYNE2

1.03e-03291293IPR002017
DomainArfGAP

AGAP4 AGAP6 ACAP3

1.03e-03291293IPR001164
DomainSPEC

KALRN SYNE1 SYNE2

1.38e-03321293SM00150
DomainSpectrin/alpha-actinin

KALRN SYNE1 SYNE2

1.38e-03321293IPR018159
DomainBiotin_lipoyl

MCCC1 PC

1.65e-0391292PF00364
DomainTPR

RGPD4 RGPD2 OGT RGPD1 RGPD3

2.02e-031291295SM00028
DomainBIOTINYL_LIPOYL

MCCC1 PC

2.05e-03101292PS50968
DomainBiotin_lipoyl

MCCC1 PC

2.05e-03101292IPR000089
DomainMyosin_head_motor_dom

MYH13 MYH7B MYO16

2.28e-03381293IPR001609
DomainMYOSIN_MOTOR

MYH13 MYH7B MYO16

2.28e-03381293PS51456
DomainMyosin_head

MYH13 MYH7B MYO16

2.28e-03381293PF00063
DomainMYSc

MYH13 MYH7B MYO16

2.28e-03381293SM00242
DomainTPR_repeat

RGPD4 RGPD2 OGT RGPD1 RGPD3

2.31e-031331295IPR019734
DomainSET

KMT5C KMT2E PRDM6

2.83e-03411293PF00856
DomainSingle_hybrid_motif

MCCC1 PC

2.99e-03121292IPR011053
Domain-

RGPD4 RGPD2 OGT RGPD1 RGPD3 CFAP46

3.17e-0320712961.25.40.10
DomainPH

KALRN TRIOBP TEC SBF1 AGAP4 AGAP6 ACAP3

3.21e-032781297SM00233
DomainPH_DOMAIN

KALRN TRIOBP TEC SBF1 AGAP4 AGAP6 ACAP3

3.27e-032791297PS50003
DomainPH_domain

KALRN TRIOBP TEC SBF1 AGAP4 AGAP6 ACAP3

3.34e-032801297IPR001849
Domain-

MCCC1 PC

3.51e-031312923.40.50.20
DomainTPR-contain_dom

RGPD4 RGPD2 OGT RGPD1 RGPD3

3.87e-031501295IPR013026
DomainSET

KMT5C KMT2E PRDM6

3.93e-03461293SM00317
DomainATP_GRASP

MCCC1 PC

4.08e-03141292PS50975
DomainATP-grasp

MCCC1 PC

4.08e-03141292IPR011761
DomainPreATP-grasp_dom

MCCC1 PC

4.08e-03141292IPR016185
DomainMyosin_N

MYH13 MYH7B

4.69e-03151292PF02736
DomainMyosin_N

MYH13 MYH7B

4.69e-03151292IPR004009
Domain-

MCCC1 PC

4.69e-031512923.30.1490.20
DomainSET_dom

KMT5C KMT2E PRDM6

4.98e-03501293IPR001214
DomainSET

KMT5C KMT2E PRDM6

4.98e-03501293PS50280
DomainPH

KALRN TRIOBP TEC SBF1 AGAP4 ACAP3

5.18e-032291296PF00169
DomainTPR-like_helical_dom

RGPD4 RGPD2 OGT RGPD1 RGPD3 CFAP46

5.63e-032331296IPR011990
Domainzf-C2H2_6

ZBTB47 ZNF442 ZNF852 ZNF324 ZNF808 ZNF324B ZKSCAN4

6.20e-033141297PF13912
DomainMyosin_tail_1

MYH13 MYH7B

6.74e-03181292PF01576
DomainATP_grasp_subdomain_1

MCCC1 PC

6.74e-03181292IPR013815
DomainMyosin_tail

MYH13 MYH7B

6.74e-03181292IPR002928
DomainZF_ZZ_2

HERC2 EP300

6.74e-03181292PS50135
DomainZF_ZZ_1

HERC2 EP300

6.74e-03181292PS01357
Domain-

MCCC1 PC

6.74e-031812923.30.470.20
DomainZZ

HERC2 EP300

6.74e-03181292PF00569
Domain-

COL7A1 TFPI2

6.74e-031812924.10.410.10
DomainPrtase_inh_Kunz-CS

COL7A1 TFPI2

6.74e-03181292IPR020901
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD2 RGPD1 RGPD3

6.76e-06181004MM1549
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CIB1 OGT GTPBP6 KALRN SYNE1 POLR2C RTL10 APC TRIOBP ZBTB47 NFKBID WHAMM ADARB1 WDR26 RALBP1 PDE4DIP PPME1 SGSM3 HERC2 PC EP300 PCNT

6.80e-0912851372235914814
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-09713749037092
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137415710750
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137411353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137430944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137438838144
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-09713747559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137417372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137438657106
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137421205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137418949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137425187515
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-09713748603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137426632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137424403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137423818861
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137423536549
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137412191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137422821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD2 RGPD1 RGPD3

7.99e-097137420682751
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD4 RGPD2 OGT KALRN SYNE1 RGPD1 APC TRIOBP GOLGA6B WDR26 ZNF462 MDN1 SBF1 RGPD3 SYNE2 MAD1L1 PDE4DIP HERC2 PCNT

8.65e-099631371928671696
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD4 RGPD2 OGT CIP2A RGPD1 APC MCCC1 WDR26 ZNF462 RGPD3 ZKSCAN4 PC PCNT

1.26e-084181371334709266
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD2 RGPD1 RGPD3

1.59e-088137421670213
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD2 RGPD1 RGPD3

1.59e-088137427412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD2 RGPD1 RGPD3

1.59e-088137421310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD2 RGPD1 RGPD3

1.59e-088137422262462
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD2 RGPD1 RGPD3

1.59e-088137428745977
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD2 RGPD1 RGPD3

2.86e-089137418394993
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD2 RGPD1 RGPD3

2.86e-089137428100513
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD2 RGPD1 RGPD3

2.86e-089137417887960
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD2 RGPD1 RGPD3

2.86e-089137411553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD2 RGPD1 RGPD3

2.86e-089137410601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD2 RGPD1 RGPD3

2.86e-08913749733766
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD2 RGPD1 RGPD3

2.86e-089137428877029
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD2 RGPD1 RGPD3

4.75e-0810137427160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD2 RGPD1 RGPD3

4.75e-0810137416332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD2 RGPD1 RGPD3

4.75e-081013748857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD2 RGPD1 RGPD3

4.75e-0810137421859863
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD2 RGPD1 RGPD3

7.44e-0811137417069463
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD2 RGPD1 RGPD3

7.44e-0811137435771867
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD2 RGPD1 RGPD3

7.44e-0811137434110283
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

GTPBP6 EP400 KALRN KMT5C UBE3B HIP1R FAM83H HOXB4 MDN1 PER2 SBF1 MAD1L1 NPRL3 OGDHL HERC2 ZNF324B PC EP300 PCNT

7.57e-0811051371935748872
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD2 RGPD1 RGPD3

1.60e-0713137431427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD2 RGPD1 RGPD3

3.04e-0715137414697343
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD2 RGPD1 RGPD3

1.60e-0622137427717094
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD4 RGPD2 EP400 RGPD1 ZNF462 RGPD3 MAD1L1

1.94e-06146137723892456
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RGPD4 RGPD2 OGT SYNE1 HAUS5 RGPD1 APC TRIOBP FAM83H PHKB PER2 RGPD3 MAD1L1 CEP135 ZNF324 PPME1 HERC2

3.21e-0611551371720360068
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD2 RGPD1 RGPD3

1.53e-0538137412791264
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

1.54e-052137211792814
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

1.54e-052137224931616
Pubmed

CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development.

APC CXCR2

1.54e-052137224338666
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

1.54e-052137234910522
Pubmed

Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.

SYNE2 PCNT

1.54e-052137230054381
Pubmed

CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis.

APC CXCR2

1.54e-052137224229710
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

1.54e-052137222768332
Pubmed

P300 regulates the human RLIP76 promoter activity and gene expression.

RALBP1 EP300

1.54e-052137223419874
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

1.54e-052137211687802
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

1.54e-052137217267447
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

1.54e-052137224718612
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

1.54e-052137224586179
Pubmed

Period 2 mutation accelerates ApcMin/+ tumorigenesis.

APC PER2

1.54e-052137219010825
Pubmed

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids.

GPBAR1 CTH

1.54e-052137225934094
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

1.54e-052137217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

1.54e-052137231578382
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RGPD4 EFCAB5 RGPD2 MYH13 GTPBP6 MYH7B SYNE1 PSMA7 MAFA RGPD1 GOLGA6B ADAMTS12 MDN1 RGPD3 SYNE2 OGDHL CFAP46 PCNT

1.54e-0514421371835575683
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

OGT UBE3B POLR2C GLG1 SCPEP1 N4BP1 HERC2 RNF138 CAPN15 PCNT

2.24e-054811371028190767
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

RGPD4 RGPD2 OGT POLR2C RGPD1 TRIOBP GOLGA6B TEC WDR26 GLG1 RALBP1 RGPD3

2.30e-057011371230196744
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SYNE1 TRIOBP ZNF462 TBC1D1 RHOBTB2 SYNE2 PCNT

3.26e-05225137712168954
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

EFCAB5 MYH13 SYNE1 ADARB1 MDN1 PPIP5K1 PC

4.18e-05234137736243803
Pubmed

A-to-I RNA editing enzyme ADAR2 regulates light-induced circadian phase-shift.

ADARB1 PER2

4.61e-053137230287844
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRC STRCP1

4.61e-053137230801007
Pubmed

Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice.

APC PKP3

4.61e-053137234823217
Pubmed

Correlation between the cystathionine-γ-lyase (CES) and the severity of peptic ulcer disease.

CTH CXCR2

4.61e-053137226060478
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

4.61e-053137216079285
Pubmed

Further delineation of genotype-phenotype correlation in homozygous 2p21 deletion syndromes: first description of patients without cystinuria.

SLC3A1 CAMKMT

4.61e-053137223794250
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

4.61e-053137210878022
Pubmed

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.

EP400 EP300

4.61e-05313729590171
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

4.61e-053137212408964
Pubmed

Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome.

SLC3A1 CAMKMT

4.61e-053137218234729
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

4.61e-053137217462627
Pubmed

A blood-based three-gene signature for the non-invasive detection of early human hepatocellular carcinoma.

EP400 CXCR2

4.61e-053137224332572
Pubmed

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.

SYNE1 SYNE2

4.61e-053137233472039
Pubmed

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

SYNE1 SYNE2

4.61e-053137225516977
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-24

4.67e-0518137318664271
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

RGPD4 RGPD2 RGPD1 IL18R1 SLC3A1 PER2 EGR4 RGPD3 WDSUB1

6.81e-05442137915815621
Pubmed

A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.

ZNF462 CAMKMT CTH

7.55e-0521137324025145
Pubmed

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.

APC ADARB1

9.19e-054137229694894
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRC STRCP1

9.19e-054137218849963
Pubmed

ADARB1 catalyzes circadian A-to-I editing and regulates RNA rhythm.

ADARB1 PER2

9.19e-054137227893733
Pubmed

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.

APC CXCR2

9.19e-054137222922255
Pubmed

Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1).

OGT KMT2E

9.19e-054137223629655
Pubmed

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

SYNE1 SYNE2

9.19e-054137216648470
Pubmed

A homolog of the human chemokine receptor CXCR1 is expressed in the mouse.

GPBAR1 CXCR2

9.19e-054137216084593
Pubmed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

SYNE1 SYNE2

9.19e-054137228716842
Pubmed

LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.

SYNE1 SYNE2

9.19e-054137223071752
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-7 ERVK-24

9.19e-054137210469592
Pubmed

Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.

CIP2A PPME1

9.19e-054137232071079
Pubmed

Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.

SYNE1 SYNE2

9.19e-054137220108321
Pubmed

Binding and modulation of p53 by p300/CBP coactivators.

EP400 EP300

9.19e-05413729194565
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

SYNE1 SYNE2

9.19e-054137219596800
InteractionRGPD2 interactions

RGPD4 RGPD2 RGPD1 ADARB1 RGPD3

7.45e-07271305int:RGPD2
InteractionCALM2 interactions

UBE3B ADAMTS12 PHKB SPATA17 TBC1D1 RHOBTB2 CAMKMT EP300 PCNT

7.75e-062061309int:CALM2
InteractionRGPD4 interactions

RGPD4 RGPD2 RGPD1 RGPD3

1.11e-05221304int:RGPD4
InteractionRGPD1 interactions

RGPD4 RGPD2 RGPD1 ADARB1 RGPD3

1.57e-05491305int:RGPD1
Cytoband15q15.3

PPIP5K1 STRC STRCP1

5.70e-0525137315q15.3
Cytoband10q11.23

ERCC6 OGDHL AGAP6

1.33e-0433137310q11.23
Cytoband19q13.43

ZSCAN5DP ZBTB45 ZNF324 ZNF324B

1.39e-0487137419q13.43
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 ZSCAN5DP ZBTB47 ZNF442 ZNF691 ZNF462 ZBTB45 ZNF852 EGR4 ZNF324 ZNF808 INSM2 ZNF324B ZKSCAN4 PRDM6

4.18e-06718941528
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD2 OGT RGPD1 RGPD3 CFAP46

3.00e-05115946769
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP4 AGAP6 ACAP3

8.78e-05179431291
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

1.59e-0449421252
GeneFamilyArfGAPs

AGAP4 AGAP6 ACAP3

6.63e-0433943395
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIOBP TEC SBF1 AGAP4 AGAP6 ACAP3

7.20e-04206946682
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT5C KMT2E PRDM6

7.25e-0434943487
GeneFamilyAnkyrin repeat domain containing

NFKBID ANKRD2 AGAP4 AGAP6 MYO16 ACAP3

1.65e-03242946403
GeneFamilyMyosin heavy chains

MYH13 MYH7B

2.69e-03159421098
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

HERC2 EP300

3.88e-031894291
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD4 RGPD2 RGPD1 GLG1 RGPD3

2.48e-06431325MM3857
ToppCellTracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EFCAB5 MYH13 HLA-DQB1 KMT5C NFKBID RFFL DPEP2 CFAP46

1.55e-0719913386dc446a5d183b01bdf227e45bd88d0b3d8b1c56a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ODAD1 ZBTB47 POMT1 ZNF442 ZBTB45 ZNF852

5.35e-061471336f5109e0f4e8b46a977a763c9c72a2df9840e3977
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ODAD1 ZBTB47 POMT1 ZNF442 ZBTB45 ZNF852

5.35e-061471336ad0c575bc9c5f201f2a7810452e8b3f741e65d89
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPBAR1 MYH13 MAFA EGR4 KIF19 CTH

1.11e-0516713365accd0bc7c95089feb2c09376d12cd8bd3773775
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADARB1 PER2 ZNF324 FGFR3 PRDM6 PCNT

1.23e-051701336b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS11 SLC3A1 ENTPD6 DCLK3 SCPEP1 CTH

1.23e-051701336833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPATA6L LCA5L SPATA17 KIF19 TEX26 CFAP46

2.04e-05186133685787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPATA6L ODAD1 LCA5L SPATA17 KIF19 CFAP46

2.59e-0519413361ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPATA6L ODAD1 SYNE1 SPATA17 KIF19 CFAP46

2.59e-0519413364a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ODAD1 SYNE1 LCA5L SPATA17 KIF19 CFAP46

2.67e-0519513363486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPATA6L ODAD1 LCA5L SPATA17 KIF19 CFAP46

2.67e-051951336e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPATA6L ODAD1 SYNE1 SPATA17 KIF19 CFAP46

2.74e-051961336d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPATA6L ODAD1 SYNE1 SPATA17 KIF19 CFAP46

2.82e-051971336e453d085182364ca347cbcc9dc995c62c3353016
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPATA6L ODAD1 SYNE1 SPATA17 KIF19 CFAP46

2.82e-051971336d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-MAIT|ICU-SEP / Disease, condition lineage and cell class

HAUS5 POMT1 NTN5 CAMKMT ZNF324B ZKSCAN4

2.99e-0519913362f10622319c6146dfed8cfe3844180c1e1d56e94
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm|5w / Sample Type, Dataset, Time_group, and Cell type.

ZNF142 ERCC6 ICA1 ZNF324B DEDD EP300

3.07e-0520013360927061536a664b4f7feb9e5b0a8c11ca0d5955c
DrugSolasodine [126-17-0]; Down 200; 9.6uM; PC3; HT_HG-U133A

COL7A1 HAUS5 APC HOXD1 GLG1 RHOBTB2 ETNK2 CAMKMT N4BP1

1.98e-0619812993749_DN
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

1.81e-0521262DOID:0110471 (implicated_via_orthology)
Diseasecystathionine measurement

TEC CTH TEC

7.01e-05191263EFO_0010474
Diseasepolymyositis

HLA-DQB1 UBE3B IL18R1

8.22e-05201263EFO_0003063
DiseaseSeminoma

ENTPD6 FGFR3

1.08e-0441262C0036631
DiseaseHypotonia-Cystinuria Syndrome

SLC3A1 CAMKMT

1.08e-0441262C1848030
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.08e-0441262cv:CN293514
Disease2p21 microdeletion syndrome

SLC3A1 CAMKMT

1.08e-0441262C4304537
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

1.08e-0441262EFO_0020830
Diseasecolorectal cancer (is_implicated_in)

ERCC6 HLA-DQB1 APC FGFR3 EP300

1.75e-041211265DOID:9256 (is_implicated_in)
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.79e-0451262C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

1.79e-0451262C0410190
DiseaseColorectal Neoplasms

COL7A1 TFPI2 SYNE1 APC HOXD1 FGFR3 EP300

1.94e-042771267C0009404
DiseaseColorectal cancer

APC FGFR3 EP300

2.06e-04271263cv:C0346629
DiseaseCOLORECTAL CANCER

APC FGFR3 EP300

2.06e-04271263114500
DiseaseNeoplasm of the large intestine

APC FGFR3 EP300

2.06e-04271263cv:C0009404
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

2.68e-0461262cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

2.68e-0461262C0410189
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

3.75e-0471262C0751337
Diseasesmoking status measurement, chronic obstructive pulmonary disease

EFCAB5 HLA-DQB1 ADCY5 ZKSCAN4

5.60e-04881264EFO_0000341, EFO_0006527
Diseasemyositis

HLA-DQB1 TEC TEC

6.21e-04391263EFO_0000783
DiseaseAdenocarcinoma of large intestine

APC DCLK3 FGFR3 EP300

7.77e-04961264C1319315
Diseasecerebral palsy (implicated_via_orthology)

AGAP4 AGAP6

7.96e-04101262DOID:1969 (implicated_via_orthology)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH13 MYH7B

7.96e-04101262DOID:0080326 (implicated_via_orthology)
DiseaseColorectal Carcinoma

COL7A1 ERCC6 KALRN TFPI2 SYNE1 APC ZNF442 HOXD1 FGFR3 EP300

8.84e-0470212610C0009402
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

1.16e-03121262DOID:11726 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH13 MYH7B

1.16e-03121262DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH13 MYH7B

1.16e-03121262DOID:2106 (implicated_via_orthology)
DiseaseAlzheimer disease, dementia

RFX4 CFAP46

1.16e-03121262MONDO_0001627, MONDO_0004975
Diseasealcohol and nicotine codependence

RGPD2 RGPD1

1.37e-03131262EFO_0004776
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH13 MYH7B

1.37e-03131262DOID:397 (implicated_via_orthology)
DiseaseBenign tumor of pancreas

APC EP300

1.37e-03131262C0347284
Diseaserevision of total hip arthroplasty

ADAMTS12 STRCP1

1.59e-03141262EFO_0020973
DiseaseTesticular Germ Cell Tumor

MAD1L1 FGFR3

1.59e-03141262C1336708
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH13 MYH7B

1.83e-03151262DOID:0050646 (implicated_via_orthology)
Disease2-hydroxyglutarate measurement

CTH PCNT

2.09e-03161262EFO_0021506
Diseasemuscular dystrophy (is_implicated_in)

SYNE1 POMT1

2.36e-03171262DOID:9884 (is_implicated_in)
DiseaseMoyamoya Disease

HLA-DQB1 PCNT

2.36e-03171262C0026654
DiseaseAllergic Reaction

HLA-DQB1 CX3CL1 CXCR2

2.50e-03631263C1527304
DiseaseGlobal developmental delay

ZNF142 KMT2E ZNF462 RHOBTB2

2.58e-031331264C0557874
DiseaseHypersensitivity

HLA-DQB1 CX3CL1 CXCR2

2.62e-03641263C0020517
Diseaseskin pigmentation measurement

KALRN ADAMTS12 SBF1 HERC2

2.87e-031371264EFO_0007009
Diseaseskin sensitivity to sun

ADAMTS12 HERC2

2.95e-03191262EFO_0004795
DiseasePancreatic carcinoma

APC EP300

2.95e-03191262C0235974
Diseasedense area measurement, mammographic density measurement

SGSM3 PRDM6

2.95e-03191262EFO_0005941, EFO_0006503
DiseaseIntellectual Disability

ZNF142 SYNE1 APC KMT2E WDR26 ZNF462 RHOBTB2

3.15e-034471267C3714756
Diseasebipolar I disorder

SYNE1 MAD1L1 PC MYO16

3.19e-031411264EFO_0009963
Diseaseallergic disease, age at onset

HLA-DQB1 IL18R1 DPEP2

3.52e-03711263EFO_0004847, MONDO_0005271
Diseaseblood pressure

SYNE1 MYO16

3.95e-03221262EFO_0004325
Diseasetransitional cell carcinoma (is_implicated_in)

APC FGFR3

3.95e-03221262DOID:2671 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
IRRSNCTNHVSTVRF

AGAP4

101

Q96P64
RRLSIQRCIQSLVHA

EP300

1731

Q09472
NRDRRIFCAILSTHS

EP400

1961

Q96L91
CTQQLRRDSDHRERA

ERVK-9

656

Q9UKH3
HYQDNISRVCEILRR

RTL10

131

Q7L3V2
SVNCESLHNRLRFLQ

CTH

226

P32929
EARCLSLRVRVAQHS

CFAP46

1731

Q8IYW2
ELQFRRCIQEFISLH

ACAP3

816

Q96P50
LEEQCLRIFSRQDTH

ANGPTL1

196

O95841
RLRVRAEYCQHETAL

DEDD

196

O75618
TRECIQARLHSQREN

ADCY5

411

O95622
FRELLRNLCTFHRTS

ERCC6

1466

Q03468
IREIQCVDSRDHRNL

ADAMTS12

1386

P58397
IRRSNCTNHVSAVRF

AGAP6

101

Q5VW22
EIRRQEFLLNCLHRD

RALBP1

401

Q15311
RTHCQRILDTVIRAN

RFX4

206

Q33E94
SRVQCRIVALDLRSH

PPME1

101

Q9Y570
LRPQEINCSVFRDHR

CAPN15

516

O75808
VIRRNKHSCFTERQV

IL18R1

111

Q13478
LDQRALQLFRHVCQE

MDN1

3516

Q9NU22
RLREDHSQLQAECER

MAD1L1

556

Q9Y6D9
CRFKRVQQRHILESE

MAFA

271

Q8NHW3
RARRIEIANCLHLND

HOXD1

256

Q9GZZ0
HIFRCNARTKEARLQ

GTPBP6

206

O43824
QHLRSALETFLRQRD

KMT5C

46

Q86Y97
CVERAFHQLFREQRP

MYO16

476

Q9Y6X6
TAHRQLQDICRLERA

GPBAR1

191

Q8TDU6
ARRISSCLDFEQHSR

HERC2

1031

O95714
RVLSTQARDRLDCVH

NFKBID

176

Q8NI38
NFAVVKECRHRETRQ

DCLK3

366

Q9C098
NEVRNFQLLRAHSCA

ETNK2

126

Q9NVF9
ECANLRRNHQRAVES

MYH7B

1631

A7E2Y1
FCRVSVRKSHENEIR

PER2

271

O15055
REIIRRLENTYCQHI

OGDHL

191

Q9ULD0
VIQETCERRNHIDRA

CXCR2

281

P25025
SRRIATVLQHEERRC

NPRL3

146

Q12980
TVLQHEERRCQYLTR

NPRL3

151

Q12980
DTSRLACFIERRKHQ

KALRN

2951

O60229
FIRRSCTPNAEVRHE

KMT2E

406

Q8IZD2
RLNCRAFSRQLAIET

LCA5L

286

O95447
RICLRNFSRSDHLTT

EGR4

516

Q05215
RDVRTACTLRAQFLQ

HAUS5

186

O94927
NDCHAEIISRRSLLR

ADARB1

391

P78563
SCREAVLHRRLQQTI

GOLGA6B

191

A6NDN3
FALAQHRCSRIVRVE

INSM2

276

Q96T92
QLDRVTCHFDNQLVR

ODAD1

121

Q96M63
TCHFDNQLVRNAALR

ODAD1

126

Q96M63
LHQRFLRCQVELDRR

PCNT

1936

O95613
HTEDIIRCRIQQRNI

EXOC6

111

Q8TAG9
LHVNSARRLEVVRNC

SBF1

556

O95248
RCERSFTQATQLSRH

PRDM6

561

Q9NQX0
RRVEIAHALCLSERQ

HOXB4

191

P17483
AVRRLEQHRSLCDEI

KIF19

596

Q2TAC6
QTFRLARSDRVLCHD

F2RL3

216

Q96RI0
DHLCRSQLQRSIFSA

POMT1

686

Q9Y6A1
QVSCLEVHAQSRRRR

PLA2G4E

206

Q3MJ16
ARCHEAERNIALRSS

RGPD3

186

A6NKT7
LERLQHIIQRRSCST

CEP135

461

Q66GS9
CRHNYQLELRTTLQR

HLA-DQB1

111

P01920
RFTDLHSIIRNIQSC

EFCAB5

786

A4FU69
SRECRAEVQRILHQR

GLG1

611

Q92896
TCDQFRRTALHRASL

ANKRD2

176

Q9GZV1
VLHDCQRYRSNIREI

HIP1R

101

O75146
HLSRLQECSRTVNER

HIP1R

931

O75146
QLHRQELERCQLDFR

GCC1

561

Q96CN9
CTQQLRRDSDHRERA

ERVK-24

546

P61566
CTQQLRRDSDHRERA

ERVK-7

546

P61567
RVLCFTNSRENSHRL

DDX51

506

Q8N8A6
DQQTLIRYICLRRHS

C1orf100

71

Q5SVJ3
CTQQLRRDSDHRERA

ERVK-21

656

P61565
LFERDCSVQRRHQKI

MCCC1

271

Q96RQ3
CHSDLSRLRQRQSLT

DPEP2

426

Q9H4A9
IREEDQCTFQHRSFR

GPR85

166

P60893
VRAQHRERVTCTRLY

COL7A1

21

Q02388
QRLTQRVLCHFSVRV

FGFR3

111

P22607
CRVNLQHVDFLRVRT

FAM83H

196

Q6ZRV2
RQELREAQTHIRATC

DHRS11

181

Q6UWP2
SHREVRQRQQCSSDR

EGFEM1P

166

Q0D2K5
FVDLDAHNRNRQTLC

PHKB

266

Q93100
LSSIHFQCRRLDRSA

OGT

61

O15294
VARCHEAERNIALRS

RGPD1

176

P0DJD0
RNPLCRFHQEVETFR

ICA1

131

Q05084
CQVRAYIRHLNRIVT

SPATA17

46

Q96L03
ARCHEAERNIALRSS

RGPD4

186

Q7Z3J3
STRTAIRECVFLHRN

SPATA6L

126

Q8N4H0
HRFIDQVLSTCRNVE

PTAR1

371

Q7Z6K3
RRHTEFFSQLDQRVL

SYNE1

961

Q8NF91
NKEIHFQRRRTTCAL

SYNE2

5746

Q8WXH0
ERNSFIHRDLAARNC

TEC

481

P42680
CAARVSEVLQNRVHR

ENTPD6

356

O75354
RRYCQQDHVLRAQVL

NTN5

361

Q8WTR8
RCHEAERNIALRSSL

RGPD2

186

P0DJD1
LLCQRFRATAFQREE

RFFL

86

Q8WZ73
LCQRHVRHLQRDALS

SCPEP1

296

Q9HB40
DRRLNHFRVCSDITL

FAM183A

106

A6NL82
FQRSICSRHESLVND

FBXL22

96

Q6P050
AFHVRRTNRVKECLA

RHOBTB2

481

Q9BYZ6
LCQESNFTRQRLLDH

RNF138

161

Q8WVD3
REAILRVARHFQCTD

SGSM3

436

Q96HU1
LHRQTAFRDRCFVSN

SLC3A1

656

Q07837
FAVTCHDRTAQQRRL

WHAMM

41

Q8TF30
QDSLSLHNITFCRDR

NOX3

231

Q9HBY0
RQRRAITVEALCENH

STRC

341

Q7RTU9
RQAEEREHTLRRCQQ

TRIOBP

2221

Q9H2D6
REHTLRRCQQEGQEL

TRIOBP

2226

Q9H2D6
RCNEDQTRHVTSRDL

POLR2C

106

P19387
ELHCVTDERNALRRS

APC

911

P25054
HRRFCELLPQEQRSV

CIB1

31

Q99828
CLRHVSVRRFESFNL

CAMKMT

56

Q7Z624
LAQADRLIAQHRCQR

CIP2A

651

Q8TCG1
RLIAQHRCQRTQAET

CIP2A

656

Q8TCG1
HRCQRTQAETEARTL

CIP2A

661

Q8TCG1
YNRLLQRCELNRHTT

PKP3

611

Q9Y446
RQVDCRVQLYHLSLR

nan

221

Q6ZTK2
RRFCRNSHLIQHERT

ZNF324

376

O75467
HFCDVTVRIREASLR

ZBTB45

31

Q96K62
ERCFTQLSDLRVHQR

ZSCAN5DP

386

P0CG00
CQESFRRRSDLTTHQ

ZNF691

176

Q5VV52
SILRCVNHRQRSLAL

SLCO4C1

601

Q6ZQN7
RRRANTLSHFPIECQ

TBC1D1

591

Q86TI0
ISSFCLVRDRNHIQS

FSBP

111

O95073
DTAFTCNSQLARHRR

ZNF808

461

Q8N4W9
QLSRCRRVQHELEEA

MYH13

1896

Q9UKX3
HIRRESESQNRESCD

USF3

1866

Q68DE3
SELLLHRQTDCERNI

ZBTB47

476

Q9UFB7
RSLRCHIIERFSESR

ZNF442

86

Q9H7R0
IQAHVRSFLCRSRLQ

UBE3B

36

Q7Z3V4
RAFCSNRNLIDHQRT

ZNF852

306

Q6ZMS4
ECERSFTRNRSLIEH

ZKSCAN4

491

Q969J2
IRQHTATIRSLCDRN

ZNF462

1226

Q96JM2
RQRRAITVEALCENH

STRCP1

341

A6NGW2
HRNRIENRFPDEATC

TFPI2

131

P48307
RQIIDRFIRTHCDTN

TEX26

271

Q8N6G2
FSCQQERALRTHQIR

ZNF142

1111

P52746
RQAVELQRDRCLYHN

WDR26

306

Q9H7D7
DLETLCQARRTEHQL

WDSUB1

311

Q8N9V3
HFRRIDSCLQTRVAF

RAPGEFL1

296

Q9UHV5
RIVINRARVECQSHR

PSMA7

81

O14818
NILHLYERDCSIQRR

PC

256

P11498
RQVSEFLSRVCQRHT

PPIP5K1

1106

Q6PFW1
RAIILETRQHRLFCA

CX3CL1

61

P78423
RRFCRNSHLIQHERT

ZNF324B

376

Q6AW86
VTSLRNSRRFNHTCL

ELFN2

361

Q5R3F8
ICQKRRFSDSEERHT

N4BP1

281

O75113
SICINDRLREQLEHR

PDE4DIP

1861

Q5VU43