Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

ADORA2A GPR3 CD3D OR5J2 GPR27 OR5AU1 OR5AS1 GPRC5D TNF GPRC5A OR10G8 OR8D4 ADGRA3 OR10G7 TMEM63A

7.89e-0613536015GO:0004888
GeneOntologyMolecularFunctionG protein-coupled receptor activity

ADORA2A GPR3 OR5J2 GPR27 OR5AU1 OR5AS1 GPRC5D GPRC5A OR10G8 OR8D4 ADGRA3 OR10G7

1.03e-058846012GO:0004930
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

PIEZO1 TMC6 TMEM63A

2.04e-0518603GO:0008381
GeneOntologyMolecularFunctiontransporter activity

SLC7A9 GPM6A SIDT2 SLC24A4 XKR9 SLC16A5 SLC22A14 PIEZO1 TMC6 ABCC11 UQCRC1 SLC25A19 TMEM63A

9.49e-0512896013GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC7A9 GPM6A SIDT2 SLC24A4 SLC16A5 SLC22A14 PIEZO1 TMC6 ABCC11 UQCRC1 SLC25A19 TMEM63A

1.71e-0411806012GO:0022857
GeneOntologyMolecularFunctionstructural constituent of myelin sheath

GPM6B PLP1

4.80e-0411602GO:0019911
GeneOntologyMolecularFunctionodorant binding

OR5J2 OR5AU1 OR5AS1 OR8D4

5.78e-04127604GO:0005549
GeneOntologyMolecularFunctionnucleobase-containing compound transmembrane transporter activity

SIDT2 ABCC11 SLC25A19

7.44e-0459603GO:0015932
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

SLC7A9 ABCC11 SLC25A19

8.20e-0461603GO:1901682
GeneOntologyMolecularFunctionolfactory receptor activity

OR5J2 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

1.83e-03431606GO:0004984
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC7A9 SLC16A5 SLC22A14 ABCC11 SLC25A19

1.86e-03293605GO:0008514
HumanPhenoHead tremor

SH3TC2 SPG11 PLP1 TMEM63A

2.77e-0547204HP:0002346
DomainMyelin_PLP

GPM6A GPM6B PLP1

3.31e-083613PF01275
DomainMYELIN_PLP_1

GPM6A GPM6B PLP1

3.31e-083613PS00575
DomainMyelin_PLP

GPM6A GPM6B PLP1

3.31e-083613IPR001614
DomainMYELIN_PLP_2

GPM6A GPM6B PLP1

3.31e-083613PS01004
DomainPLP

GPM6A GPM6B PLP1

3.31e-083613SM00002
DomainMyelin_PLP_CS

GPM6A GPM6B PLP1

3.31e-083613IPR018237
DomainGPCR_Rhodpsn_7TM

ADORA2A GPR3 OR5J2 GPR27 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.05e-04670619IPR017452
Domain7tm_1

ADORA2A GPR3 OR5J2 GPR27 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.29e-04677619PF00001
DomainG_PROTEIN_RECEP_F1_1

ADORA2A GPR3 OR5J2 GPR27 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.58e-04685619PS00237
DomainG_PROTEIN_RECEP_F1_2

ADORA2A GPR3 OR5J2 GPR27 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.82e-04691619PS50262
DomainGPCR_Rhodpsn

ADORA2A GPR3 OR5J2 GPR27 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.86e-04692619IPR000276
DomainOlfact_rcpt

OR5J2 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

1.75e-03393616IPR000725
DomainGPCR_3

GPRC5D GPRC5A

2.12e-0321612IPR000337
DomainG_PROTEIN_RECEP_F3_4

GPRC5D GPRC5A

2.32e-0322612PS50259
Domain7tm_3

GPRC5D GPRC5A

2.32e-0322612PF00003
DomainGPCR_3_C

GPRC5D GPRC5A

2.32e-0322612IPR017978
DomainG_PROTEIN_RECEP_F3_2

GPRC5D GPRC5A

2.32e-0322612PS00980
DomainG_PROTEIN_RECEP_F3_3

GPRC5D GPRC5A

2.32e-0322612PS00981
DomainG_PROTEIN_RECEP_F3_1

GPRC5D GPRC5A

2.32e-0322612PS00979
Pubmed

Molecular cloning of M6: identification of a PLP/DM20 gene family.

GPM6A GPM6B PLP1

5.39e-0936238398137
Pubmed

Expression of members of the proteolipid protein gene family in the developing murine central nervous system.

GPM6A GPM6B PLP1

5.39e-0936238807448
Pubmed

Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.

GPM6A GPM6B PLP1

6.42e-071062324917275
Pubmed

A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease.

ADORA2A TNF

3.13e-06262219776336
Pubmed

PLP1 and GPM6B intragenic copy number analysis by MAPH in 262 patients with hypomyelinating leukodystrophies: Identification of one partial triplication and two partial deletions of PLP1.

GPM6B PLP1

3.13e-06262216416265
Pubmed

Identification of GPM6A and GPM6B as potential new human lymphoid leukemia-associated oncogenes.

GPM6A GPM6B

3.13e-06262224916915
Pubmed

Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.

ADORA2A TNF

3.13e-06262222923002
Pubmed

Chromosomal mapping of the human M6 genes.

GPM6A GPM6B

3.13e-0626228661015
Pubmed

A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.

GPM6B PLP1

3.13e-06262223322581
Pubmed

EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones.

GPM6A GPM6B

9.37e-0636221286213
Pubmed

Maturational changes in cell surface antigen expression in the mouse retina and optic pathway.

GPM6A GPM6B

9.37e-0636229554989
Pubmed

Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions.

GPM6A ADORA2A

3.12e-05562231286866
Pubmed

Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.

CASP10 TNF

3.12e-05562219423537
Pubmed

A TNFα/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.

ZBTB17 TNF

3.12e-05562237040844
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5J2 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.24e-0534062611875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5J2 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.24e-0534062611802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5J2 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.40e-0534362632295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5J2 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

3.57e-0534662614611657
Pubmed

The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.

TNF ADIPOR2

4.67e-05662222479352
Pubmed

Doxorubicin-mediated apoptosis in glioma cells requires NFAT3.

CASP10 TNF

4.67e-05662219784808
Pubmed

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation.

ZBTB17 TNF

6.53e-05762219815509
Pubmed

SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.

SFRP2 PPP1CB

6.53e-05762217123353
Pubmed

Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death.

ZBTB17 TNF

8.69e-05862226212014
Pubmed

Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression.

GPRC5D GPRC5A

8.69e-05862215677768
Pubmed

Genotyping sleep disorders patients.

ADORA2A TNF

1.12e-04962220396431
Pubmed

Additional microsatellite markers for mouse genome mapping.

CD3D TNF PLP1

1.98e-04636231794058
Pubmed

Gpr158 mediates osteocalcin's regulation of cognition.

GPRC5D GPRC5A

2.81e-041462228851741
Pubmed

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

CASP10 TNF

3.23e-041562212887920
Pubmed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

CASP10 RPGR HSD17B3 ZNF471 PLP1 ZBTB1 PPP1CB

3.47e-0474262726871637
Pubmed

The human olfactory receptor gene family.

OR5J2 OR5AU1 OR5AS1 OR10G8 OR8D4 OR10G7

4.05e-0454162614983052
Pubmed

Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.

TEX10 ZBTB1

5.24e-041962215334068
Pubmed

Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins.

GPM6A GPM6B

6.42e-042162223284715
Pubmed

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.

GPM6A GPM6B UQCRC1 PLP1 PPP1CB

7.67e-0440362530562941
Pubmed

Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model.

CD3D TNF

8.41e-042462215245428
Pubmed

Replication of genetic association studies in asthma and related phenotypes.

TNF LTC4S

9.89e-042662220395963
Pubmed

Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.

ADORA2A TNF ADIPOR2

1.21e-0311762318996102
Pubmed

Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.

PLA2G2C PLP1 ADIPOR2

1.34e-031216238827514
Pubmed

Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.

GPM6B PLP1

1.41e-033162223142642
Pubmed

Integral and associated lysosomal membrane proteins.

SIDT2 SPG11 TMEM63A

1.50e-0312662317897319
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

ADORA2A TMC6 UQCRC1 PLP1 ADGRA3 TMEM63A

1.50e-0369762628298427
Pubmed

Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.

TNF LTC4S

1.59e-033362219028820
Pubmed

Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis.

TNF LTC4S

1.59e-033362218974840
Pubmed

Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.

TNF LTC4S

1.69e-033462220603037
GeneFamilyG protein-coupled receptors, Class C orphans

GPRC5D GPRC5A

1.38e-047472285
GeneFamilyOlfactory receptors, family 5

OR5J2 OR5AU1 OR5AS1

3.08e-03112473152
GeneFamilySolute carriers

SLC7A9 SLC24A4 SLC16A5 SLC22A14 SLC25A19

3.50e-03395475752
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 HSD17B3 PLP1 TMEM63A

2.19e-07184626a2191dd5546efd357b23e625beb3c5820476f243
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 HSD17B3 PLP1 TMEM63A

2.26e-07185626b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 HSD17B3 PLP1 TMEM63A

2.41e-0718762697e520705491c8f52a32025311a9fa7b9176979a
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 HSD17B3 PLP1 TMEM63A

2.65e-0719062607f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 HSD17B3 PLP1 TMEM63A

2.65e-07190626ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 HSD17B3 PLP1 TMEM63A

2.73e-071916262b056cbe2e82e056e1f798974999378460eb1d16
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-7|TCGA-Stomach / Sample_Type by Project: Shred V9

GPM6A GPM6B ANKRD63 PLA2G2C PLP1

3.12e-06162625b115b5799137122bd60696f8ae2aebadad6cd044
ToppCellTCGA-Brain|World / Sample_Type by Project: Shred V9

GPM6A GPM6B GDAP1L1 CYP46A1 PLP1

3.95e-06170625f78e360a6a44d599ec0d207cba4704e50aa314f8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

5.36e-06181625a8e9ea73c24109a5d4d28bc0577cc869ad932a4d
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

5.65e-061836255472cdce6d99314d229418412acf1fff6340db7d
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

5.80e-061846255939527d24d299e562e707469c9123890edd76be
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

5.96e-061856251d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

5.96e-06185625b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.12e-06186625d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.12e-0618662590eaf6ffb4ce0c34fa1e79f0c8f36f217f44973b
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.12e-06186625bd8a9753df219084e19e7f94447856e86608325c
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.28e-06187625f0de86ef25e344d9b1860ee26308877d6c25ed31
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.28e-06187625b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.44e-0618862514072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.44e-0618862560242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.44e-06188625b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.61e-0618962570eea8c94fa56bb15bee8065de47acea156794e9
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 HSD17B3 PLP1 TMEM63A

6.61e-06189625784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.61e-06189625b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 PLP1 TMEM63A

6.61e-0618962542ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 PLP1 TMEM63A

6.61e-0618962537ecbd73408d462b47d7e5611f203143e08a2689
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.78e-061906256b101359f397020a21e2bfd15851cb48e71f4502
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 HSD17B3 PLP1 TMEM63A

6.96e-061916252110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 TMC6 PLP1 TMEM63A

6.96e-06191625a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPM6A GPM6B SH3TC2 HSD17B3 PLP1

8.49e-061996252b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|PND01-03-samps / Age Group, Lineage, Cell class and subclass

TNF LTC4S ANKRD63 ADIPOR2

3.46e-05132624617644597726e881cd343e57f6edb5a98473b421
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-3|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

SIDT2 SLC24A4 ZDHHC7 SIGLEC11

3.89e-051366244f5e0b6c7d6e3e922af4daa7c3eb56490455c1df
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-9|TCGA-Colorectal / Sample_Type by Project: Shred V9

GPM6A GPM6B PLA2G2C PLP1

7.14e-05159624f376bf6cd0ed374211edac3c384f3a78f0caef2a
ToppCellfacs-Trachea-nan-18m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6A SLC16A5 STOML1 SLC25A19

7.32e-051606245c9281706009558c8361bfa76169f43ffc0f7947
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GPR3 SH3TC2 SLC16A5 SLMAP

7.68e-05162624373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPM6A SLC16A5 STOML1 SLC25A19

8.05e-051646244274a4f225cabf61f0fe27d8ea162b4eba612f87
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPM6A SLC16A5 STOML1 SLC25A19

8.05e-05164624d62143450f59097ad4b34603a6257f897a769ead
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 HSD17B3 PLP1 TMEM63A

1.08e-0417762480aee5154f21810be0645d003b06568d4dcecc36
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPM6A SFRP2 SLC22A14 NEU3

1.18e-04181624330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPM6A SFRP2 SLC22A14 NEU3

1.18e-041816243f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6A TMEM150A SLC16A5 PLA2G2C

1.18e-0418162497022416d0f5a5ba9c9bd5e70ce95cf4cb19af89
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 PLP1 TMEM63A

1.20e-04182624d524ad5cf00f05ee27c9db2ffa2d4e30a1e2e21a
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPM6A GPM6B XKR9 UQCRC1

1.23e-04183624a742c9a33f32058f9fb051733e3e736bc704d8e6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 PLP1 TMEM63A

1.23e-0418362493213124e55d1b673dd345188caf8b5bd31d99fe
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 PLP1 TMEM63A

1.25e-04184624f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 PLP1 TMEM63A

1.36e-04188624d9692b6048d9b85524a07a1807bdd4757731c151
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 PLP1 TMEM63A

1.36e-04188624505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 PLP1 TMEM63A

1.42e-041906242de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 TMC6 PLP1 TMEM63A

1.42e-04190624396b7225c2430db3dc55a3d0db70239b71987229
ToppCellASK440-Mesenchymal|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

GPM6B SFRP2 PLPP3 ABCC11

1.45e-04191624f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCellASK440-Mesenchymal-Fibroblast|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

GPM6B SFRP2 PLPP3 ABCC11

1.45e-04191624387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3TC2 PLPP3 PLP1 TMEM63A

1.45e-04191624f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADORA2A CD58 SLC25A19 ZNF471

1.48e-04192624181d22fbb98a619a7f302c0f6623cee94c49a253
ToppCellfacs-Thymus-nan-3m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIDT2 SLC16A5 PLP1 PPP1CB

1.54e-04194624f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCellfacs-Thymus-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIDT2 SLC16A5 PLP1 PPP1CB

1.54e-04194624cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCellfacs-Thymus-nan-3m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIDT2 SLC16A5 PLP1 PPP1CB

1.54e-0419462466c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCellTracheal-10x5prime-Stromal-Schwann|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPM6B SH3TC2 ARHGAP36 PLP1

1.60e-04196624b6226163d9fc93ecfff2115bb74408303a000490
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPM6B GPRC5D PLP1 TMEM63A

1.63e-0419762454fb207638e211f8efdb13003ae62a6b1f003b09
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B PLPP3 PLP1 TMEM63A

1.66e-04198624731a90f7e68b19e387499d63e3979af78b503b0c
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Radial_glial-oRG|3_mon / Sample Type, Dataset, Time_group, and Cell type.

SFRP2 PLPP3 CD58 PLP1

1.66e-0419862472dc49aa107d0cc6206eb67b577c73e190855125
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Radial_glial|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

GPM6B SFRP2 PLPP3 CD58

1.69e-041996246fd9774f18da3e6f114427f55a8879ac90c41350
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Radial_glial-oRG|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

GPM6B SFRP2 PLPP3 CD58

1.69e-04199624151bda6821b52cfb4491474892ecb45781522837
ToppCellMacroglial|World / cells hierarchy compared to all cells using T-Statistic

SH3TC2 PLPP3 PLP1 TMEM63A

1.73e-04200624e6935ad49216d2500c15c05cbc2b89402c65e838
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Macroglial-Astrocyte|3m / Sample Type, Dataset, Time_group, and Cell type.

GPM6B SFRP2 CD58 PLP1

1.73e-0420062498d7f577b31a603bf835bf9b4ea31999445cf0e5
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Slc17a7-Slc17a6.Calb1-Rorb-Il1rapl2_(Layer_5b)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC7A9 CD3D OR5J2

1.90e-0480623402aba070f0728ebda9db7a8fa85441533755ff4
Drugnarciclasine

ABCC11 CASP10 TNF

1.01e-068613CID000072376
DrugLeflunomide [75706-12-6]; Up 200; 14.8uM; HL60; HT_HG-U133A

CD3D SIDT2 ZBTB17 SLC22A14 STOML1 NEU3

1.18e-051906162539_UP
DrugBretylium tosylate [61-75-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

SLC22A14 STOML1 TMC6 EML2 GPRC5D RPGR

1.45e-051976163394_DN
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Up 200; 10uM; PC3; HT_HG-U133A

ADORA2A GPR3 GPR27 SLC22A14 GPRC5D TMEM63A

1.45e-051976166335_UP
DrugNaloxone hydrochloride [357-08-4]; Down 200; 11uM; MCF7; HT_HG-U133A

GPR3 PLPP3 STOML1 TMC6 RPGR TMEM63A

1.45e-051976165606_DN
Drugcis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Down 200; 100uM; PC3; HG-U133A

GPR3 PLPP3 NEU3 GPRC5D HSD17B3 TMEM63A

1.50e-05198616664_DN
DrugPF-00539758-00 [351321-34-1]; Down 200; 10uM; PC3; HT_HG-U133A

GPM6A SLC16A5 GPR27 GPRC5D ZBTB1 TMEM63A

1.54e-051996166379_DN
DrugChlorpropamide [94-20-2]; Up 200; 14.4uM; MCF7; HT_HG-U133A

GPM6A GPM6B GPR3 GPR27 SLC22A14 EML2

1.58e-052006165391_UP
Diseasedepressive disorder (implicated_via_orthology)

GPM6A GPM6B PLP1

1.08e-0522583DOID:1596 (implicated_via_orthology)
DiseaseDrug Allergy

ADORA2A TNF LTC4S

4.51e-0535583C0013182
DiseaseVentricular Dysfunction

ADORA2A TNF

1.06e-048582C0242973
Diseaseintellectual disability (implicated_via_orthology)

GPM6A GPM6B PLP1

4.40e-0475583DOID:1059 (implicated_via_orthology)
Diseasenon-alcoholic steatohepatitis (biomarker_via_orthology)

TNF ADIPOR2

5.07e-0417582DOID:0080547 (biomarker_via_orthology)
DiseaseSepticemia

ADORA2A TNF

1.02e-0324582C0036690
DiseaseSepsis

ADORA2A TNF

1.02e-0324582C0243026
DiseaseSevere Sepsis

ADORA2A TNF

1.02e-0324582C1719672
DiseasePyemia

ADORA2A TNF

1.02e-0324582C0034189
Diseasenon-alcoholic fatty liver disease (is_marker_for)

TNF ADIPOR2

1.29e-0327582DOID:0080208 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
LLLALGVFCFAGHET

CD3D

116

P04234
ISTGFCAACHGCLFI

ADORA2A

66

P29274
LCFHIFLTCVVFVGG

ADGRA3

801

Q8IWK6
ACGHGAVLEFLVRSF

ANKRD63

126

C9JTQ0
ALVCCASGLFGSLGH

SLC24A4

31

Q8NFF2
FGILFSICFSCLLAH

GPRC5A

101

Q8NFJ5
THLLGCVFFLCLGIF

ADIPOR2

151

Q86V24
ACCQFIEKHGLSAVG

ARHGAP36

241

Q6ZRI8
LCGCAFTLADVLLGA

GDAP1L1

261

Q96MZ0
FHIVNGAVVCGCTLG

PLA2G2C

86

Q5R387
AVIHGGCILRLSFCG

OR8D4

156

Q8NGM9
ASHCIVVLCFFGPGL

OR10G7

241

Q8NGN6
LGVLSVVCLLHCFGF

CD58

11

P19256
VVCLLHCFGFISCFS

CD58

16

P19256
ALFCGCGHEALSGTV

GPM6A

41

P51674
CFHAAFLLLGVGVTR

GPR27

106

Q9NS67
GIFFHEGAAALCGLV

LTC4S

71

Q16873
HGVGLCFALFLSECV

ABCC11

201

Q96J66
ASHCIVVLCFFGPGL

OR10G8

241

Q8NGN5
HLCFGVFITTEGFLL

OR5J2

101

Q8NH18
LTILVCLAHTCFGCF

TMEM63A

706

O94886
SGVALFCGCGHVALA

GPM6B

46

Q13491
FCGCGHVALAGTVAI

GPM6B

51

Q13491
ICYAETGLLGAHFVC

UQCRC1

346

P31930
LGLVLHFAAVFCIGS

GPR3

91

P46089
SLVHVCLTFRLSFCG

OR5AS1

156

Q8N127
AAIVDEKIFCCHGGL

PPP1CB

161

P62140
AVLLAFGLCCTFVHR

CYP46A1

11

Q9Y6A2
FGVLFALCFSCLLAH

GPRC5D

96

Q9NZD1
ACGVLATLGALCFAE

SLC7A9

71

P82251
FAIFCISRLLCSHGA

IGFL1

11

Q6UW32
ADGDCFVFCILTHGR

CASP10

346

Q92851
CLLNSGVVHLTCTGF

AHCTF1

481

Q8WYP5
HVLGLGVFDRAVCCV

EML2

151

O95834
CGCLAHEILAGFLSL

HSD17B3

266

P37058
AIILGHCFFAVGAVL

SLC22A14

271

Q9Y267
HCFFAVGAVLLTGIA

SLC22A14

276

Q9Y267
FLCLSFGHSECLLLV

OR2A1;

101

Q8NGT9
LLCKVCGDVASGFHY

NR1D2

101

Q14995
FLRFIVKLVACGGCH

RPGR

346

Q92834
LFLASHCCLGSARGL

SFRP2

11

Q96HF1
LCALECGIPKHFGLF

SIDT2

536

Q8NBJ9
VAFPAGLLFVCLHCA

TMEM150A

146

Q86TG1
VLAGFAQGALVACCI

PLPP3

256

O14495
TGCIFSLKFCGAHVV

OR5AU1

211

Q8NGC0
GLLIQEGHFFCRALC

SH3TC2

171

Q8TF17
KSGCVFLFFICVRGH

NEU3

96

Q9UQ49
GAACVCFLELLGLDS

SPG11

1251

Q96JI7
TFLVFGGIFLHCCIC

SLC16A5

171

O15375
PSCLCHGLISFLGFL

STOML1

51

Q9UBI4
KSGGDCTFIHQFIEC

SLMAP

401

Q14BN4
ESHFLCVDCGLAFGT

ZNF574

361

Q6ZN55
SLHLCFCGLISFLSI

SERINC4

261

A6NH21
TAGCVFGVICKLLDH

TEX10

771

Q9NXF1
CGFGFSCEKLLDEHV

ZBTB1

221

Q9Y2K1
GLLCDCTFVVDGVHF

ZBTB17

21

Q13105
NCIDCGKAFSVHIGL

ZNF471

376

Q9BX82
SVHALILCGFQFISC

ZDHHC7

186

Q9NXF8
CLGTALGCAVAVHVF

TMC6

441

Q7Z403
SRLCVAVGCFGAGHL

PIEZO1

246

Q92508
FLCDLCGFAGGTRHA

ZNF407

1686

Q9C0G0
REFSVHFVCGGLAAC

SLC25A19

116

Q9HC21
GAGVAALLAFCSCLV

SIGLEC11

566

Q96RL6
VAGATTLFCLLHFGV

TNF

41

P01375
HCFLLLHCLQGGVFT

XKR9

76

Q5GH70
FFGVALFCGCGHEAL

PLP1

26

P60201